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Mary Kay H. Pflum - Publications

Affiliations: 
2001- Chemistry Wayne State University, Detroit, MI, United States 
Area:
Biochemistry, Cell Biology
Website:
https://clasprofiles.wayne.edu/profile/aj9044
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34 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Karaj E, Sindi SH, Kuganesan N, Koranne RA, Knoff JR, James AW, Fu Y, Kotsull LN, Pflum MK, Shah Z, Taylor WR, Tillekeratne LMV. First-in-Class Dual Mechanism Ferroptosis-HDAC Inhibitor Hybrids. Journal of Medicinal Chemistry. PMID 36306372 DOI: 10.1021/acs.jmedchem.2c01276  0.304
2019 Tillekeratne LMV, Al-Hamashi AA, Dlamini S, Taylor W, Koranne R, Pflum MK, Negmeldin AT, Knoff J. In Search of Selectivity: Design, Synthesis, and Biological Evaluation of New Classes of HDAC Inhibitors Proceedings. 22: 63. DOI: 10.3390/PROCEEDINGS2019022063  0.436
2017 Nalawansha DA, Gomes ID, Wambua MK, Pflum MK. HDAC Inhibitor-Induced Mitotic Arrest Is Mediated by Eg5/KIF11 Acetylation. Cell Chemical Biology. PMID 28392145 DOI: 10.1016/J.Chembiol.2017.03.008  0.808
2017 Negmeldin AT, Padige G, Bieliauskas AV, Pflum MK. Structural Requirements of HDAC Inhibitors: SAHA Analogues Modified at the C2 Position Display HDAC6/8 Selectivity. Acs Medicinal Chemistry Letters. 8: 281-286. PMID 28337317 DOI: 10.1021/Acsmedchemlett.6B00124  0.824
2017 Nalawansha DA, Pflum MK. LSD1 Substrate Binding and Gene Expression Are Affected by HDAC1-Mediated Deacetylation. Acs Chemical Biology. 12: 254-264. PMID 27977115 DOI: 10.1021/Acschembio.6B00776  0.539
2017 Embogama DM, Pflum MK. K-BILDS: A Kinase Substrate Discovery Tool. Chembiochem : a European Journal of Chemical Biology. 18: 136-141. PMID 27860220 DOI: 10.1002/Cbic.201600511  0.421
2016 Almaliti J, Al-Hamashi AA, Negmeldin AT, Hanigan CL, Perera L, Pflum MK, Casero RA, Tillekeratne LM. Largazole Analogues Embodying Radical Changes in the Depsipeptide Ring: Development of a More Selective and Highly Potent Analogue. Journal of Medicinal Chemistry. PMID 27809521 DOI: 10.1021/Acs.Jmedchem.6B01271  0.445
2016 Dedigama-Arachchige PM, Pflum MK. K-CLASP: A Tool to Identify Phosphosite Specific Kinases and Interacting Proteins. Acs Chemical Biology. 11: 3251-3255. PMID 27726338 DOI: 10.1021/Acschembio.6B00289  0.412
2016 Bieliauskas AV, Weerasinghe SV, Negmeldin AT, Pflum MK. Structural Requirements of Histone Deacetylase Inhibitors: SAHA Analogs Modified on the Hydroxamic Acid. Archiv Der Pharmazie. PMID 27062198 DOI: 10.1002/Ardp.201500472  0.802
2016 Senevirathne C, Embogama DM, Anthony TA, Fouda AE, Pflum MK. The generality of kinase-catalyzed biotinylation. Bioorganic & Medicinal Chemistry. 24: 12-9. PMID 26672511 DOI: 10.1016/J.Bmc.2015.11.029  0.403
2015 Padige G, Negmeldin AT, Pflum MK. Development of an ELISA-Based HDAC Activity Assay for Characterization of Isoform-Selective Inhibitors. Journal of Biomolecular Screening. 20: 1277-85. PMID 26232305 DOI: 10.1177/1087057115598118  0.604
2015 Fouda AE, Pflum MK. A Cell-Permeable ATP Analogue for Kinase-Catalyzed Biotinylation. Angewandte Chemie (International Ed. in English). 54: 9618-21. PMID 26119262 DOI: 10.1002/Anie.201503041  0.36
2014 Garre S, Senevirathne C, Pflum MK. A comparative study of ATP analogs for phosphorylation-dependent kinase-substrate crosslinking. Bioorganic & Medicinal Chemistry. 22: 1620-5. PMID 24529309 DOI: 10.1016/J.Bmc.2014.01.034  0.408
2014 Wambua MK, Nalawansha DA, Negmeldin AT, Pflum MK. Mutagenesis studies of the 14 Å internal cavity of histone deacetylase 1: insights toward the acetate-escape hypothesis and selective inhibitor design. Journal of Medicinal Chemistry. 57: 642-50. PMID 24405391 DOI: 10.1021/Jm401837E  0.803
2013 Senevirathne C, Pflum MK. Biotinylated phosphoproteins from kinase-catalyzed biotinylation are stable to phosphatases: implications for phosphoproteomics. Chembiochem : a European Journal of Chemical Biology. 14: 381-7. PMID 23335220 DOI: 10.1002/Cbic.201200626  0.449
2012 Senevirathne C, Green KD, Pflum MK. Kinase-Catalyzed Biotinylation. Current Protocols in Chemical Biology. 4: 83-100. PMID 25177527 DOI: 10.1002/9780470559277.Ch110228  0.624
2012 Suwal S, Senevirathne C, Garre S, Pflum MK. Structural analysis of ATP analogues compatible with kinase-catalyzed labeling. Bioconjugate Chemistry. 23: 2386-91. PMID 23116557 DOI: 10.1021/Bc300404S  0.781
2012 Choi SE, Pflum MK. The structural requirements of histone deacetylase inhibitors: suberoylanilide hydroxamic acid analogs modified at the C6 position. Bioorganic & Medicinal Chemistry Letters. 22: 7084-6. PMID 23089527 DOI: 10.1016/J.Bmcl.2012.09.093  0.524
2011 Choi SE, Weerasinghe SV, Pflum MK. The structural requirements of histone deacetylase inhibitors: Suberoylanilide hydroxamic acid analogs modified at the C3 position display isoform selectivity. Bioorganic & Medicinal Chemistry Letters. 21: 6139-42. PMID 21889343 DOI: 10.1016/J.Bmcl.2011.08.027  0.814
2010 Weerasinghe SV, Wambua M, Pflum MK. A histone deacetylase-dependent screen in yeast. Bioorganic & Medicinal Chemistry. 18: 7586-92. PMID 20863708 DOI: 10.1016/J.Bmc.2010.08.045  0.77
2010 Suwal S, Pflum MK. Phosphorylation-dependent kinase-substrate cross-linking. Angewandte Chemie (International Ed. in English). 49: 1627-30. PMID 20108289 DOI: 10.1002/Anie.200905244  0.775
2009 Green KD, Pflum MK. Exploring kinase cosubstrate promiscuity: monitoring kinase activity through dansylation. Chembiochem : a European Journal of Chemical Biology. 10: 234-7. PMID 19107758 DOI: 10.1002/Cbic.200800393  0.644
2008 Weerasinghe SV, Estiu G, Wiest O, Pflum MK. Residues in the 11 A channel of histone deacetylase 1 promote catalytic activity: implications for designing isoform-selective histone deacetylase inhibitors. Journal of Medicinal Chemistry. 51: 5542-51. PMID 18729444 DOI: 10.1021/Jm800081J  0.793
2008 Bieliauskas AV, Pflum MK. Isoform-selective histone deacetylase inhibitors. Chemical Society Reviews. 37: 1402-13. PMID 18568166 DOI: 10.1039/B703830P  0.818
2008 Mohrig JR, Alberg DG, Cartwright CH, Pflum MK, Aldrich JS, Anderson JK, Anderson SR, Fimmen RL, Snover AK. Stereochemistry of 1,2-elimination reactions at the E2-E1cB interface--tert-butyl 3-tosyloxybutanoate and its thioester. Organic & Biomolecular Chemistry. 6: 1641-6. PMID 18421398 DOI: 10.1039/b801592a  0.718
2008 Singh EK, Ravula S, Pan CM, Pan PS, Vasko RC, Lapera SA, Weerasinghe SV, Pflum MK, McAlpine SR. Synthesis and biological evaluation of histone deacetylase inhibitors that are based on FR235222: a cyclic tetrapeptide scaffold. Bioorganic & Medicinal Chemistry Letters. 18: 2549-54. PMID 18381239 DOI: 10.1016/J.Bmcl.2008.03.047  0.819
2007 Karwowska-Desaulniers P, Ketko A, Kamath N, Pflum MK. Histone deacetylase 1 phosphorylation at S421 and S423 is constitutive in vivo, but dispensable in vitro. Biochemical and Biophysical Research Communications. 361: 349-55. PMID 17643391 DOI: 10.1016/J.Bbrc.2007.06.167  0.789
2007 Bieliauskas AV, Weerasinghe SV, Pflum MK. Structural requirements of HDAC inhibitors: SAHA analogs functionalized adjacent to the hydroxamic acid. Bioorganic & Medicinal Chemistry Letters. 17: 2216-9. PMID 17307359 DOI: 10.1016/J.Bmcl.2007.01.117  0.788
2007 Green KD, Pflum MK. Kinase-catalyzed biotinylation for phosphoprotein detection. Journal of the American Chemical Society. 129: 10-1. PMID 17199263 DOI: 10.1021/Ja066828O  0.636
2006 Warthaka M, Karwowska-Desaulniers P, Pflum MK. Phosphopeptide modification and enrichment by oxidation-reduction condensation. Acs Chemical Biology. 1: 697-701. PMID 17184134 DOI: 10.1021/Cb6003564  0.749
2006 Kamath N, Karwowska-Desaulniers P, Pflum MK. Limited proteolysis of human histone deacetylase 1. Bmc Biochemistry. 7: 22. PMID 17022812 DOI: 10.1186/1471-2091-7-22  0.793
2004 Pflum MK. Grafting miniature DNA binding proteins. Chemistry & Biology. 11: 3-4. PMID 15112983 DOI: 10.1016/J.Chembiol.2004.01.010  0.324
2001 Pflum MK, Tong JK, Lane WS, Schreiber SL. Histone deacetylase 1 phosphorylation promotes enzymatic activity and complex formation. The Journal of Biological Chemistry. 276: 47733-41. PMID 11602581 DOI: 10.1074/Jbc.M105590200  0.807
2001 Pflum MK, Schneider TL, Hall D, Schepartz A. Hepatitis B virus X protein activates transcription by bypassing CREB phosphorylation, not by stabilizing bZIP-DNA complexes. Biochemistry. 40: 693-703. PMID 11170386 DOI: 10.1021/Bi0011936  0.727
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