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Daniel H. Appella - Publications

National Institutes of Health, Bethesda, MD 
 2001-2004 Chemistry Northwestern University, Evanston, IL 
Organic Chemistry

73 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Helmold Hait S, Hogge CJ, Rahman MA, Ko EJ, Hunegnaw R, Mushtaq Z, Enyindah-Asonye G, Hoang T, Miller Jenkins LM, Appella E, Appella DH, Robert-Guroff M. An SAMT-247 Microbicide Provides Potent Protection against Intravaginal Simian Immunodeficiency Virus Infection of Rhesus Macaques, whereas an Added Vaccine Component Elicits Mixed Outcomes. Journal of Immunology (Baltimore, Md. : 1950). PMID 32393514 DOI: 10.4049/jimmunol.2000165  0.4
2019 Zhu L, Rossi M, Cohen A, Pham J, Zheng H, Dattaroy D, Mukaibo T, Melvin JE, Langel JL, Hattar S, Matschinsky FM, Appella DH, Doliba NM, Wess J. Allosteric modulation of β-cell M muscarinic acetylcholine receptors greatly improves glucose homeostasis in lean and obese mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 31451647 DOI: 10.1073/pnas.1904943116  0.4
2019 Nikolayevskiy H, Robello M, Scerba MT, Pasternak EH, Saha M, Hartman TL, Buchholz CA, Buckheit RW, Durell SR, Appella DH. The structure-activity profile of mercaptobenzamides' anti-HIV activity suggests that thermodynamics of metabolism is more important than binding affinity to the target. European Journal of Medicinal Chemistry. 178: 818-837. PMID 31252286 DOI: 10.1016/j.ejmech.2019.06.020  1
2019 Miller Jenkins LM, Paine E, Deshmukh L, Nikolayevskiy H, Lyons GC, Scerba MT, George Rosenker K, Luecke H, Louis JM, Chertova E, Gorelick RJ, Ott DE, Clore GM, Appella DH. Inhibition of HIV Maturation via Selective Unfolding and Crosslinking of Gag Polyprotein by a Mercaptobenzamide Acetylator. Journal of the American Chemical Society. PMID 31042030 DOI: 10.1021/jacs.9b02743  1
2019 Shank N, George Rosenker KM, Englund EA, Dix AV, Rastede EE, Appella DH. Synthesis and Application of KγT Peptide Nucleic Acids. Methods in Molecular Biology (Clifton, N.J.). 1973: 131-145. PMID 31016699 DOI: 10.1007/978-1-4939-9216-4_8  1
2018 Zheng H, Saha M, Appella DH. Synthesis of Fmoc-Protected ( S, S)- trans-Cyclopentane Diamine Monomers Enables the Preparation and Study of Conformationally Restricted Peptide Nucleic Acids. Organic Letters. PMID 30460846 DOI: 10.1021/acs.orglett.8b03374  1
2018 Nikolayevskiy H, Scerba MT, Deschamps JR, Appella DH. Reaction Kinetics Direct a Rational Synthesis of an HIV-1 Inactivator of Nucleocapsid Protein 7 and Provide Mechanistic Insight into Cellular Metabolism and Antiviral Activity. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29653024 DOI: 10.1002/chem.201801253  1
2018 Debnath S, Kosek D, Tagad HD, Durell SR, Appella DH, Acevedo R, Grishaev A, Dyda F, Appella E, Mazur SJ. A trapped human PPM1A-phosphopeptide complex reveals structural features critical for regulation of PPM protein phosphatase activity. The Journal of Biological Chemistry. PMID 29602904 DOI: 10.1074/jbc.RA117.001213  1
2018 Tagad HD, Debnath S, Clausse V, Saha M, Mazur S, Appella E, Appella DH. Chemical features important for activity in a class of inhibitors targeting the Wip1 flap subdomain. Chemmedchem. PMID 29476592 DOI: 10.1002/cmdc.201700779  1
2018 Deshmukh L, Tugarinov V, Appella DH, Clore GM. Targeting a dark excited state of HIV-1 nucleocapsid by anti-retroviral thioesters revealed by NMR. Angewandte Chemie (International Ed. in English). PMID 29345807 DOI: 10.1002/anie.201713172  0.36
2017 Liu Y, Lou G, Norton JT, Wang C, Kandela I, Tang S, Shank NI, Gupta P, Huang M, Avram MJ, Green R, Mazar A, Appella D, Chen Z, Huang S. 6-Methoxyethylamino-numonafide inhibits hepatocellular carcinoma xenograft growth as a single agent and in combination with sorafenib. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28821631 DOI: 10.1096/fj.201700306RR  1
2017 Yang Y, Zhu J, Hassink M, Jenkins LMM, Wan Y, Appella DH, Xu J, Appella E, Zhang X. A novel preventive strategy against HIV-1 infection: combinatorial use of inhibitors targeting the nucleocapsid and fusion proteins. Emerging Microbes & Infections. 6: e40. PMID 28588284 DOI: 10.1038/emi.2017.26  0.4
2017 Saha M, Scerba MT, Shank NI, Hartman TL, Buchholz CA, Buckheit RW, Durell SR, Appella DH. Probing Mercaptobenzamides as HIV Inactivators via Nucleocapsid Protein 7. Chemmedchem. PMID 28395128 DOI: 10.1002/cmdc.201700141  0.72
2016 Hartman TL, Yang L, Helfrick AN, Hassink M, Shank NI, Rosenker KG, Scerba MT, Saha M, Hughes E, Wang AQ, Xu X, Gupta P, Buckheit RW, Appella DH. Preclinical evaluation of a mercaptobenzamide and its prodrug for NCp7-Targeted inhibition of human immunodeficiency virus. Antiviral Research. PMID 27568924 DOI: 10.1016/j.antiviral.2016.08.022  1
2015 Gupta P, Rastede EE, Appella DH. Multivalent (L)Kγ-PNA oligomers bind to a human telomere DNA G-rich sequence to form quadruplexes. Bioorganic & Medicinal Chemistry Letters. 25: 4757-60. PMID 26259805 DOI: 10.1016/j.bmcl.2015.07.075  0.52
2015 Ugaonkar SR, Clark JT, English LB, Johnson TJ, Buckheit KW, Bahde RJ, Appella DH, Buckheit RW, Kiser PF. An Intravaginal Ring for the Simultaneous Delivery of an HIV-1 Maturation Inhibitor and Reverse-Transcriptase Inhibitor for Prophylaxis of HIV Transmission. Journal of Pharmaceutical Sciences. 104: 3426-39. PMID 26149293 DOI: 10.1002/jps.24551  1
2015 Dix AV, Conroy JL, George Rosenker KM, Sibley DR, Appella DH. PNA-Based Multivalent Scaffolds Activate the Dopamine D2 Receptor. Acs Medicinal Chemistry Letters. 6: 425-9. PMID 25893044 DOI: 10.1021/ml500478m  1
2015 Gaynutdinov TI, Englund EA, Appella DH, Onyshchenko MI, Neumann RD, Panyutin IG. G-quadruplex formation between G-rich PNA and homologous sequences in oligonucleotides and supercoiled plasmid DNA. Nucleic Acid Therapeutics. 25: 78-84. PMID 25650982 DOI: 10.1089/nat.2014.0517  1
2015 Gupta P, Rastede EE, Appella DH. Multivalent LKγ-PNA oligomers bind to a human telomere DNA G-rich sequence to form quadruplexes Bioorganic and Medicinal Chemistry Letters. DOI: 10.1016/j.bmcl.2015.07.075  0.52
2014 Fu Y, Mi L, Sanda M, Silverstein S, Aggarwal M, Wang D, Gupta P, Goldman R, Appella DH, Chung FL. A Click Chemistry Approach to Identify Protein Targets of Cancer Chemopreventive Phenethyl Isothiocyanate. Rsc Advances. 4: 3920-3923. PMID 28725420 DOI: 10.1039/C3RA46849F  0.52
2014 Dix AV, Moss SM, Phan K, Hoppe T, Paoletta S, Kozma E, Gao ZG, Durell SR, Jacobson KA, Appella DH. Programmable nanoscaffolds that control ligand display to a G-protein-coupled receptor in membranes to allow dissection of multivalent effects. Journal of the American Chemical Society. 136: 12296-303. PMID 25116377 DOI: 10.1021/ja504288s  1
2014 Englund EA, Gupta P, Micklitsch CM, Onyshchenko MI, Remeeva E, Neumann RD, Panyutin IG, Appella DH. PPG peptide nucleic acids that promote DNA guanine quadruplexes. Chembiochem : a European Journal of Chemical Biology. 15: 1887-90. PMID 25044379 DOI: 10.1002/cbic.201402224  1
2014 Englund EA, Zhang N, Appella DH. Cyclopentane peptide nucleic acids. Methods in Molecular Biology (Clifton, N.J.). 1050: 13-8. PMID 24297347 DOI: 10.1007/978-1-62703-553-8_2  1
2014 Fu Y, Mi L, Sanda M, Silverstein S, Aggarwal M, Wang D, Gupta P, Goldman R, Appella DH, Chung FL. A click chemistry approach to identify protein targets of cancer chemopreventive phenethyl isothiocyanate Rsc Advances. 4: 3920-3923. DOI: 10.1039/c3ra46849f  1
2013 Ranjan N, Kumar S, Watkins D, Wang D, Appella DH, Arya DP. Recognition of HIV-TAR RNA using neomycin-benzimidazole conjugates. Bioorganic & Medicinal Chemistry Letters. 23: 5689-93. PMID 24012122 DOI: 10.1016/j.bmcl.2013.08.014  1
2013 Micklitsch CM, Oquare BY, Zhao C, Appella DH. Cyclopentane-peptide nucleic acids for qualitative, quantitative, and repetitive detection of nucleic acids. Analytical Chemistry. 85: 251-7. PMID 23214925 DOI: 10.1021/ac3026459  1
2013 Simister PC, Luccarelli J, Thompson S, Appella DH, Feller SM, Hamilton AD. Novel inhibitors of a Grb2 SH3C domain interaction identified by a virtual screen. Bioorganic & Medicinal Chemistry. 21: 4027-33. PMID 23182216 DOI: 10.1016/j.bmc.2012.10.023  1
2012 Pokorski JK, Appella DH. Combinatorial Synthesis, Screening, and Binding Studies of Highly Functionalized Polyamino-amido Oligomers for Binding to Folded RNA. Journal of Nucleic Acids. 2012: 971581. PMID 22957210 DOI: 10.1155/2012/971581  1
2012 Panyutin IG, Onyshchenko MI, Englund EA, Appella DH, Neumann RD. Targeting DNA G-quadruplex structures with peptide nucleic acids. Current Pharmaceutical Design. 18: 1984-91. PMID 22376112 DOI: 10.2174/138161212799958440  1
2012 Kumar S, Kellish P, Robinson WE, Wang D, Appella DH, Arya DP. Click dimers to target HIV TAR RNA conformation. Biochemistry. 51: 2331-47. PMID 22339203 DOI: 10.1021/bi201657k  0.52
2012 Englund EA, Wang D, Fujigaki H, Sakai H, Micklitsch CM, Ghirlando R, Martin-Manso G, Pendrak ML, Roberts DD, Durell SR, Appella DH. Programmable multivalent display of receptor ligands using peptide nucleic acid nanoscaffolds. Nature Communications. 3: 614. PMID 22233624 DOI: 10.1038/ncomms1629  1
2011 Bahde RJ, Appella DH, Trenkle WC. A one-pot preparation of N-2-mercaptobenzoyl-amino amides. Tetrahedron Letters. 52: 4103-4105. PMID 21931465 DOI: 10.1016/j.tetlet.2011.05.115  1
2011 Onyshchenko MI, Gaynutdinov TI, Englund EA, Appella DH, Neumann RD, Panyutin IG. Quadruplex formation is necessary for stable PNA invasion into duplex DNA of BCL2 promoter region. Nucleic Acids Research. 39: 7114-23. PMID 21593130 DOI: 10.1093/nar/gkr259  1
2011 Liu Y, Norton JT, Witschi MA, Xu Q, Lou G, Wang C, Appella DH, Chen Z, Huang S. Methoxyethylamino-numonafide is an efficacious and minimally toxic amonafide derivative in murine models of human cancer. Neoplasia (New York, N.Y.). 13: 453-60. PMID 21532886 DOI: 10.1593/neo.101738  1
2011 Hayashi R, Tanoue K, Durell SR, Chatterjee DK, Jenkins LM, Appella DH, Appella E. Optimization of a cyclic peptide inhibitor of Ser/Thr phosphatase PPM1D (Wip1). Biochemistry. 50: 4537-49. PMID 21528848 DOI: 10.1021/bi101949t  1
2011 Macadangdang B, Zhang N, Lund PE, Marple AH, Okabe M, Gottesman MM, Appella DH, Kimchi-Sarfaty C. Inhibition of multidrug resistance by SV40 pseudovirion delivery of an antigene peptide nucleic acid (PNA) in cultured cells. Plos One. 6: e17981. PMID 21445346 DOI: 10.1371/journal.pone.0017981  1
2010 Miller Jenkins LM, Ott DE, Hayashi R, Coren LV, Wang D, Xu Q, Schito ML, Inman JK, Appella DH, Appella E. Small-molecule inactivation of HIV-1 NCp7 by repetitive intracellular acyl transfer. Nature Chemical Biology. 6: 887-9. PMID 20953192 DOI: 10.1038/nchembio.456  1
2010 Iera JA, Jenkins LM, Kajiyama H, Kopp JB, Appella DH. Solid-phase synthesis and screening of N-acylated polyamine (NAPA) combinatorial libraries for protein binding. Bioorganic & Medicinal Chemistry Letters. 20: 6500-3. PMID 20932761 DOI: 10.1016/j.bmcl.2010.09.054  1
2010 Zhang N, Appella DH. Advantages of peptide nucleic acids as diagnostic platforms for detection of nucleic acids in resource-limited settings. The Journal of Infectious Diseases. 201: S42-5. PMID 20225945 DOI: 10.1086/650389  0.48
2009 Wang D, Iera J, Baker H, Hogan P, Ptak R, Yang L, Hartman T, Buckheit RW, Desjardins A, Yang A, Legault P, Yedavalli V, Jeang KT, Appella DH. Multivalent binding oligomers inhibit HIV Tat-TAR interaction critical for viral replication. Bioorganic & Medicinal Chemistry Letters. 19: 6893-7. PMID 19896372 DOI: 10.1016/j.bmcl.2009.10.078  1
2009 Hayashi R, Wang D, Hara T, Iera JA, Durell SR, Appella DH. N-acylpolyamine inhibitors of HDM2 and HDMX binding to p53. Bioorganic & Medicinal Chemistry. 17: 7884-93. PMID 19880322 DOI: 10.1016/j.bmc.2009.10.032  1
2009 Waters ML, Appella DH. Mimicking nature: from fundamentals to applications. Current Opinion in Chemical Biology. 13: 641-2. PMID 19854670 DOI: 10.1016/j.cbpa.2009.10.007  1
2009 Onyshchenko MI, Gaynutdinov TI, Englund EA, Appella DH, Neumann RD, Panyutin IG. Stabilization of G-quadruplex in the BCL2 promoter region in double-stranded DNA by invading short PNAs. Nucleic Acids Research. 37: 7570-80. PMID 19820116 DOI: 10.1093/nar/gkp840  1
2009 Rossi M, Bang JK, Mazur S, Iera JA, Phillips DC, Zambetti GP, Appella DH. Induction of apoptosis promoted by Bang52; a small molecule that downregulates Bcl-x(L). Bioorganic & Medicinal Chemistry Letters. 19: 2429-34. PMID 19349174 DOI: 10.1016/j.bmcl.2009.03.067  1
2008 Xu Q, Appella DH. Aziridination of aliphatic alkenes catalyzed by N-heterocyclic carbene copper complexes. Organic Letters. 10: 1497-500. PMID 18335951 DOI: 10.1021/ol800288b  0.84
2008 Norton JT, Witschi MA, Luong L, Kawamura A, Ghosh S, Stack MS, Sim E, Avram MJ, Appella DH, Huang S. Synthesis and anticancer activities of 6-amino amonafide derivatives. Anti-Cancer Drugs. 19: 23-36. PMID 18043127 DOI: 10.1097/CAD.0b013e3282f00e17  1
2008 Bang J, Yamaguchi H, Durell SR, Appella E, Appella DH. A small molecular scaffold for selective inhibition of Wip1 phosphatase. Chemmedchem. 3: 230-2. PMID 18022979 DOI: 10.1002/cmdc.200700281  1
2007 Zhang N, Appella DH. Colorimetric detection of anthrax DNA with a Peptide nucleic acid sandwich-hybridization assay. Journal of the American Chemical Society. 129: 8424-5. PMID 17569540 DOI: 10.1021/ja072744j  0.48
2007 Pokorski JK, Jenkins LM, Feng H, Durell SR, Bai Y, Appella DH. Introduction of a triazole amino acid into a peptoid oligomer induces turn formation in aqueous solution. Organic Letters. 9: 2381-3. PMID 17506576 DOI: 10.1021/ol070817y  1
2007 Englund EA, Appella DH. Gamma-substituted peptide nucleic acids constructed from L-lysine are a versatile scaffold for multifunctional display. Angewandte Chemie (International Ed. in English). 46: 1414-8. PMID 17133633 DOI: 10.1002/anie.200603483  1
2006 Englund EA, Xu Q, Witschi MA, Appella DH. PNA-DNA duplexes, triplexes, and quadruplexes are stabilized with trans-cyclopentane units. Journal of the American Chemical Society. 128: 16456-7. PMID 17177367 DOI: 10.1021/ja064317w  1
2006 Xu Q, Appella DH. Practical synthesis of trans-tert-butyl-2-aminocyclopentylcarbamate and resolution of enantiomers. The Journal of Organic Chemistry. 71: 8655-7. PMID 17064052 DOI: 10.1021/jo061409v  0.84
2006 Witschi MA, Pokorski JK, Appella DH. Peptide nucleic acid microarrays made with (S,S)-trans-cyclopentane-constrained peptide nucleic acids. Methods in Enzymology. 410: 189-200. PMID 16938552 DOI: 10.1016/S0076-6879(06)10009-9  1
2006 Hara T, Durell SR, Myers MC, Appella DH. Probing the structural requirements of peptoids that inhibit HDM2-p53 interactions. Journal of the American Chemical Society. 128: 1995-2004. PMID 16464101 DOI: 10.1021/ja056344c  1
2005 Englund EA, Appella DH. Synthesis of gamma-substituted peptide nucleic acids: a new place to attach fluorophores without affecting DNA binding. Organic Letters. 7: 3465-7. PMID 16048318 DOI: 10.1021/ol051143z  1
2005 Guler MO, Pokorski JK, Appella DH, Stupp SI. Enhanced oligonucleotide binding to self-assembled nanofibers. Bioconjugate Chemistry. 16: 501-3. PMID 15898715 DOI: 10.1021/bc050053b  1
2005 Myers MC, Wang J, Iera JA, Bang JK, Hara T, Saito S, Zambetti GP, Appella DH. A new family of small molecules to probe the reactivation of mutant p53. Journal of the American Chemical Society. 127: 6152-3. PMID 15853303 DOI: 10.1021/ja045752y  1
2005 Pokorski JK, Nam JM, Vega RA, Mirkin CA, Appella DH. Cyclopentane-modified PNA improves the sensitivity of nanoparticle-based scanometric DNA detection. Chemical Communications (Cambridge, England). 2101-3. PMID 15846413 DOI: 10.1039/b418383e  1
2005 Pokorski JK, Myers MC, Appella DH. Cyclopropane PNA: Observable triplex melting in a PNA constrained with a 3-membered ring Tetrahedron Letters. 46: 915-917. DOI: 10.1016/j.tetlet.2004.12.061  1
2004 Myers MC, Pokorski JK, Appella DH. Peptide nucleic acids with a flexible secondary amine in the backbone maintain oligonucleotide binding affinity. Organic Letters. 6: 4699-702. PMID 15575664 DOI: 10.1021/ol0480980  1
2004 Pokorski JK, Witschi MA, Purnell BL, Appella DH. (S,S)-trans-cyclopentane-constrained peptide nucleic acids. a general backbone modification that improves binding affinity and sequence specificity. Journal of the American Chemical Society. 126: 15067-73. PMID 15548003 DOI: 10.1021/ja046280q  1
2004 Englund EA, Gopi HN, Appella DH. An efficient synthesis of a probe for protein function: 2,3-diaminopropionic acid with orthogonal protecting groups. Organic Letters. 6: 213-5. PMID 14723531 DOI: 10.1021/ol0361599  1
2003 Myers MC, Witschi MA, Larionova NV, Franck JM, Haynes RD, Hara T, Grajkowski A, Appella DH. A cyclopentane conformational restraint for a peptide nucleic acid: design, asymmetric synthesis, and improved binding affinity to DNA and RNA. Organic Letters. 5: 2695-8. PMID 12868892 DOI: 10.1021/ol0348811  1
2000 Appella DH, LePlae PR, Raguse TL, Gellman SH. (R,R,R)-2,5-diaminocylohexanecarboxylic acid, a building block for water-soluble, helix-forming beta-peptides. The Journal of Organic Chemistry. 65: 4766-9. PMID 10959893 DOI: 10.1021/jo000277h  1
2000 Barchi JJ, Huang X, Appella DH, Christianson LA, Durell SR, Gellman SH. Solution conformations of helix-forming β-amino acid homooligomers Journal of the American Chemical Society. 122: 2711-2718. DOI: 10.1021/ja9930014  1
2000 Moritani Y, Appella DH, Jurkauskas V, Buchwald SL. Synthesis of β-alkyl cyclopentanones in high enantiomeric excess via copper-catalyzed asymmetric conjugate reduction [17] Journal of the American Chemical Society. 122: 6797-6798. DOI: 10.1021/ja0009525  1
1999 Appella DH, Moritani Y, Shintani R, Ferreira EM, Buchwald SL. Asymmetric conjugate reduction of α,β-unsaturated esters using a chiral phosphine - Copper catalyst [14] Journal of the American Chemical Society. 121: 9473-9474. DOI: 10.1021/ja992366l  1
1999 Appella DH, Christianson LA, Klein DA, Richards MR, Powell DR, Gellman SH. Synthesis and structural characterization of helix-forming β-peptides: Trans-2-aminocyclopentanecarboxylic acid oligomers Journal of the American Chemical Society. 121: 7574-7581. DOI: 10.1021/ja991185g  1
1999 Appella DH, Christianson LA, Karle IL, Powell DR, Gellman SH. Synthesis and characterization of trans-2-aminocyclohexanecarboxylic acid oligomers: An unnatural helical secondary structure and implications for β-peptide tertiary structure Journal of the American Chemical Society. 121: 6206-6212. DOI: 10.1021/ja990748l  1
1999 Troutman MV, Appella DH, Buchwald SL. Asymmetric hydrogenation of unfunctionalized tetrasubstituted olefins with a cationic zirconocene catalyst [13] Journal of the American Chemical Society. 121: 4916-4917. DOI: 10.1021/ja990535w  1
1999 Appella DH, Barchi JJ, Durell SR, Gellman SH. Formation of short, stable helices in aqueous solution by β-amino acid hexamers [2] Journal of the American Chemical Society. 121: 2309-2310. DOI: 10.1021/ja983918n  1
1997 Appella DH, Christianson LA, Klein DA, Powell DR, Huang X, Barchi JJ, Gellman SH. Residue-based control of helix shape in β-peptide oligomers Nature. 387: 381-384. PMID 9163422 DOI: 10.1038/387381a0  1
1996 Appella DH, Christianson LA, Karle IL, Powell DR, Gellman SH. β-Peptide foldamers: Robust helix formation in a new family of β-amino acid oligomers Journal of the American Chemical Society. 118: 13071-13072. DOI: 10.1021/ja963290l  1
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