Dirk J. Snyders - Publications

Affiliations: 
Universiteit Antwerpen (Belgium) 
Area:
Biochemistry

67 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Van Theemsche KM, Van de Sande DV, Snyders DJ, Labro AJ. Hydrophobic Drug/Toxin Binding Sites in Voltage-Dependent K and Na Channels. Frontiers in Pharmacology. 11: 735. PMID 32499709 DOI: 10.3389/fphar.2020.00735  0.84
2020 Coonen L, Mayeur E, De Neuter N, Snyders DJ, Cuello LG, Labro AJ. The Selectivity Filter Is Involved in the U-Type Inactivation Process of Kv2.1 and Kv3.1 Channels. Biophysical Journal. PMID 32365329 DOI: 10.1016/j.bpj.2020.03.032  0.84
2020 Möller L, Regnier G, Labro AJ, Blunck R, Snyders DJ. Determining the correct stoichiometry of Kv2.1/Kv6.4 heterotetramers, functional in multiple stoichiometrical configurations. Proceedings of the National Academy of Sciences of the United States of America. PMID 32284408 DOI: 10.1073/pnas.1916166117  0.84
2019 Van de Sande DV, Kopljar I, Teisman A, Gallacher DJ, Snyders DJ, Lu HR, Labro AJ. Pharmacological Profile of the Sodium Current in Human Stem Cell-Derived Cardiomyocytes Compares to Heterologous Nav1.5+β1 Model. Frontiers in Pharmacology. 10: 1374. PMID 31920633 DOI: 10.3389/fphar.2019.01374  0.84
2017 Bocksteins E, Snyders DJ, Holmgren M. Independent movement of the voltage sensors in KV2.1/KV6.4 heterotetramers. Scientific Reports. 7: 41646. PMID 28139741 DOI: 10.1038/srep41646  1
2016 Stas JI, Bocksteins E, Jensen CS, Schmitt N, Snyders DJ. The anticonvulsant retigabine suppresses neuronal KV2-mediated currents. Scientific Reports. 6: 35080. PMID 27734968 DOI: 10.1038/srep35080  1
2016 Shen H, Bocksteins E, Kondrychyn I, Snyders D, Korzh V. Functional antagonism of alpha-subunits of Kv channel in developing brain ventricular system. Development (Cambridge, England). PMID 27729411 DOI: 10.1242/dev.140467  1
2016 Regnier G, Bocksteins E, Marei WF, Pintelon I, Timmermans JP, Leroy JL, Snyders DJ. Targeted deletion of the Kv6.4 subunit causes male sterility due to disturbed spermiogenesis. Reproduction, Fertility, and Development. PMID 27677211 DOI: 10.1071/RD16075  1
2016 Martínez-Morales E, Kopljar I, Rainier JD, Tytgat J, Snyders DJ, Labro AJ. Gambierol and n-alkanols inhibit Shaker Kv channel via distinct binding sites outside the K(+) pore. Toxicon : Official Journal of the International Society On Toxinology. PMID 27475861 DOI: 10.1016/j.toxicon.2016.07.017  0.84
2016 Hassiki R, Labro AJ, Benlasfar Z, Vincke C, Somia M, Ayeb ME, Muyldermans S, Snyders DJ, Bouhaouala-Zahar B. Dromedary immune response and specific Kv2.1 antibody generation using a specific immunization approach. International Journal of Biological Macromolecules. PMID 27320844 DOI: 10.1016/j.ijbiomac.2016.06.031  0.84
2016 Regnier G, Bocksteins E, Van de Vijver G, Snyders DJ, van Bogaert PP. The contribution of Kv2.2-mediated currents decreases during the postnatal development of mouse dorsal root ganglion neurons. Physiological Reports. 4. PMID 27033450 DOI: 10.14814/phy2.12731  1
2016 Kopljar I, Grottesi A, de Block T, Rainier JD, Tytgat J, Labro AJ, Snyders DJ. Voltage-sensor conformation shapes the intra-membrane drug binding site that determines gambierol affinity in Kv channels. Neuropharmacology. PMID 26956727 DOI: 10.1016/j.neuropharm.2016.03.010  0.84
2015 Labro AJ, Priest MF, Lacroix JJ, Snyders DJ, Bezanilla F. Kv3.1 uses a timely resurgent K(+) current to secure action potential repolarization. Nature Communications. 6: 10173. PMID 26673941 DOI: 10.1038/ncomms10173  1
2015 Martínez-Morales E, Kopljar I, Snyders DJ, Labro AJ. Alkanols inhibit voltage-gated K(+) channels via a distinct gating modifying mechanism that prevents gate opening. Scientific Reports. 5: 17402. PMID 26616025 DOI: 10.1038/srep17402  0.84
2015 Stas JI, Bocksteins E, Labro AJ, Snyders DJ. Modulation of Closed-State Inactivation in Kv2.1/Kv6.4 Heterotetramers as Mechanism for 4-AP Induced Potentiation. Plos One. 10: e0141349. PMID 26505474 DOI: 10.1371/journal.pone.0141349  1
2014 Bocksteins E, Mayeur E, Van Tilborg A, Regnier G, Timmermans JP, Snyders DJ. The subfamily-specific interaction between Kv2.1 and Kv6.4 subunits is determined by interactions between the N- and C-termini. Plos One. 9: e98960. PMID 24901643 DOI: 10.1371/journal.pone.0098960  1
2014 Martinez-Morales E, Snyders DJ, Labro AJ. Mutations in the S6 gate isolate a late step in the activation pathway and reduce 4-AP sensitivity in shaker K(v) channel. Biophysical Journal. 106: 134-44. PMID 24411245 DOI: 10.1016/j.bpj.2013.11.025  0.84
2013 Veys K, Snyders D, De Schutter E. Kv3.3b expression defines the shape of the complex spike in the Purkinje cell. Frontiers in Cellular Neuroscience. 7: 205. PMID 24312005 DOI: 10.3389/fncel.2013.00205  1
2013 Kopljar I, Labro AJ, de Block T, Rainier JD, Tytgat J, Snyders DJ. The ladder-shaped polyether toxin gambierol anchors the gating machinery of Kv3.1 channels in the resting state. The Journal of General Physiology. 141: 359-69. PMID 23401573 DOI: 10.1085/jgp.201210890  0.84
2012 Labro AJ, Lacroix JJ, Villalba-Galea CA, Snyders DJ, Bezanilla F. Molecular mechanism for depolarization-induced modulation of Kv channel closure. The Journal of General Physiology. 140: 481-93. PMID 23071266 DOI: 10.1085/jgp.201210817  1
2012 Labro AJ, Snyders DJ. Being flexible: the voltage-controllable activation gate of kv channels. Frontiers in Pharmacology. 3: 168. PMID 22993508 DOI: 10.3389/fphar.2012.00168  0.84
2012 Abderemane-Ali F, Es-Salah-Lamoureux Z, Delemotte L, Kasimova MA, Labro AJ, Snyders DJ, Fedida D, Tarek M, Baró I, Loussouarn G. Dual effect of phosphatidylinositol (4,5)-bisphosphate PIP(2) on Shaker K(+) [corrected] channels. The Journal of Biological Chemistry. 287: 36158-67. PMID 22932893 DOI: 10.1074/jbc.M112.382085  0.84
2012 Veys K, Labro AJ, De Schutter E, Snyders DJ. Quantitative single-cell ion-channel gene expression profiling through an improved qRT-PCR technique combined with whole cell patch clamp. Journal of Neuroscience Methods. 209: 227-34. PMID 22728251 DOI: 10.1016/j.jneumeth.2012.06.008  1
2012 Bocksteins E, Van de Vijver G, Van Bogaert PP, Snyders DJ. Kv3 channels contribute to the delayed rectifier current in small cultured mouse dorsal root ganglion neurons. American Journal of Physiology. Cell Physiology. 303: C406-15. PMID 22673617 DOI: 10.1152/ajpcell.00343.2011  1
2012 Bocksteins E, Labro AJ, Snyders DJ, Mohapatra DP. The electrically silent Kv6.4 subunit confers hyperpolarized gating charge movement in Kv2.1/Kv6.4 heterotetrameric channels. Plos One. 7: e37143. PMID 22615922 DOI: 10.1371/journal.pone.0037143  1
2012 Bocksteins E, Snyders DJ. Electrically silent Kv subunits: their molecular and functional characteristics. Physiology (Bethesda, Md.). 27: 73-84. PMID 22505664 DOI: 10.1152/physiol.00023.2011  1
2012 Vandendriessche T, Kopljar I, Jenkins DP, Diego-Garcia E, Abdel-Mottaleb Y, Vermassen E, Clynen E, Schoofs L, Wulff H, Snyders D, Tytgat J. Purification, molecular cloning and functional characterization of HelaTx1 (Heterometrus laoticus): the first member of a new κ-KTX subfamily. Biochemical Pharmacology. 83: 1307-17. PMID 22305749 DOI: 10.1016/j.bcp.2012.01.021  1
2011 Bocksteins E, Ottschytsch N, Timmermans JP, Labro AJ, Snyders DJ. Functional interactions between residues in the S1, S4, and S5 domains of Kv2.1. European Biophysics Journal : Ebj. 40: 783-93. PMID 21455829 DOI: 10.1007/s00249-011-0694-3  1
2011 Labro AJ, Boulet IR, Choveau FS, Mayeur E, Bruyns T, Loussouarn G, Raes AL, Snyders DJ. The S4-S5 linker of KCNQ1 channels forms a structural scaffold with the S6 segment controlling gate closure. The Journal of Biological Chemistry. 286: 717-25. PMID 21059661 DOI: 10.1074/jbc.M110.146977  1
2011 Choveau FS, Rodriguez N, Abderemane Ali F, Labro AJ, Rose T, Dahimène S, Boudin H, Le Hénaff C, Escande D, Snyders DJ, Charpentier F, Mérot J, Baró I, Loussouarn G. KCNQ1 channels voltage dependence through a voltage-dependent binding of the S4-S5 linker to the pore domain. The Journal of Biological Chemistry. 286: 707-16. PMID 20940310 DOI: 10.1074/jbc.M110.146324  1
2010 Labro AJ, Boulet IR, Timmermans JP, Ottschytsch N, Snyders DJ. The rate-dependent biophysical properties of the LQT1 H258R mutant are counteracted by a dominant negative effect on channel trafficking. Journal of Molecular and Cellular Cardiology. 48: 1096-104. PMID 19913547 DOI: 10.1016/j.yjmcc.2009.10.027  1
2009 Bocksteins E, Labro AJ, Mayeur E, Bruyns T, Timmermans JP, Adriaensen D, Snyders DJ. Conserved negative charges in the N-terminal tetramerization domain mediate efficient assembly of Kv2.1 and Kv2.1/Kv6.4 channels. The Journal of Biological Chemistry. 284: 31625-34. PMID 19717558 DOI: 10.1074/jbc.M109.039479  1
2009 Costagliola A, Van Nassauw L, Snyders D, Adriaensen D, Timmermans JP. Voltage-gated delayed rectifier K v 1-subunits may serve as distinctive markers for enteroglial cells with different phenotypes in the murine ileum. Neuroscience Letters. 461: 80-4. PMID 19549557 DOI: 10.1016/j.neulet.2009.06.053  0.44
2009 Kopljar I, Labro AJ, Cuypers E, Johnson HW, Rainier JD, Tytgat J, Snyders DJ. A polyether biotoxin binding site on the lipid-exposed face of the pore domain of Kv channels revealed by the marine toxin gambierol. Proceedings of the National Academy of Sciences of the United States of America. 106: 9896-901. PMID 19482941 DOI: 10.1073/pnas.0812471106  0.84
2009 Bocksteins E, Raes AL, Van de Vijver G, Bruyns T, Van Bogaert PP, Snyders DJ. Kv2.1 and silent Kv subunits underlie the delayed rectifier K+ current in cultured small mouse DRG neurons. American Journal of Physiology. Cell Physiology. 296: C1271-8. PMID 19357235 DOI: 10.1152/ajpcell.00088.2009  1
2008 Labro AJ, Raes AL, Grottesi A, Van Hoorick D, Sansom MS, Snyders DJ. Kv channel gating requires a compatible S4-S5 linker and bottom part of S6, constrained by non-interacting residues. The Journal of General Physiology. 132: 667-80. PMID 19029374 DOI: 10.1085/jgp.200810048  0.84
2008 Labro AJ, Grottesi A, Sansom MS, Raes AL, Snyders DJ. A Kv channel with an altered activation gate sequence displays both "fast" and "slow" activation kinetics. American Journal of Physiology. Cell Physiology. 294: C1476-84. PMID 18385285 DOI: 10.1152/ajpcell.00479.2007  0.84
2008 Cuypers E, Abdel-Mottaleb Y, Kopljar I, Rainier JD, Raes AL, Snyders DJ, Tytgat J. Gambierol, a toxin produced by the dinoflagellate Gambierdiscus toxicus, is a potent blocker of voltage-gated potassium channels. Toxicon : Official Journal of the International Society On Toxinology. 51: 974-83. PMID 18313714 DOI: 10.1016/j.toxicon.2008.01.004  1
2007 Boulet IR, Labro AJ, Raes AL, Snyders DJ. Role of the S6 C-terminus in KCNQ1 channel gating. The Journal of Physiology. 585: 325-37. PMID 17932138 DOI: 10.1113/jphysiol.2007.145813  1
2007 Saenen JB, Paulussen AD, Jongbloed RJ, Marcelis CL, Gilissen RA, Aerssens J, Snyders DJ, Raes AL. A single hERG mutation underlying a spectrum of acquired and congenital long QT syndrome phenotypes. Journal of Molecular and Cellular Cardiology. 43: 63-72. PMID 17531263 DOI: 10.1016/j.yjmcc.2007.04.012  0.36
2006 Saenen JB, Labro AJ, Raes A, Snyders DJ. Modulation of HERG gating by a charge cluster in the N-terminal proximal domain. Biophysical Journal. 91: 4381-91. PMID 16997865 DOI: 10.1529/biophysj.106.087247  0.84
2006 Van Laer L, Carlsson PI, Ottschytsch N, Bondeson ML, Konings A, Vandevelde A, Dieltjens N, Fransen E, Snyders D, Borg E, Raes A, Van Camp G. The contribution of genes involved in potassium-recycling in the inner ear to noise-induced hearing loss. Human Mutation. 27: 786-95. PMID 16823764 DOI: 10.1002/humu.20360  1
2006 Boulet IR, Raes AL, Ottschytsch N, Snyders DJ. Functional effects of a KCNQ1 mutation associated with the long QT syndrome. Cardiovascular Research. 70: 466-74. PMID 16564513 DOI: 10.1016/j.cardiores.2006.02.006  1
2005 Ottschytsch N, Raes AL, Timmermans JP, Snyders DJ. Domain analysis of Kv6.3, an electrically silent channel. The Journal of Physiology. 568: 737-47. PMID 16096342 DOI: 10.1113/jphysiol.2005.090142  1
2005 Labro AJ, Raes AL, Snyders DJ. Coupling of voltage sensing to channel opening reflects intrasubunit interactions in kv channels. The Journal of General Physiology. 125: 71-80. PMID 15623896 DOI: 10.1085/jgp.200409194  0.84
2003 Van Hoorick D, Raes A, Keysers W, Mayeur E, Snyders DJ. Differential modulation of Kv4 kinetics by KCHIP1 splice variants. Molecular and Cellular Neurosciences. 24: 357-66. PMID 14572458  0.44
2003 Labro AJ, Raes AL, Bellens I, Ottschytsch N, Snyders DJ. Gating of shaker-type channels requires the flexibility of S6 caused by prolines. The Journal of Biological Chemistry. 278: 50724-31. PMID 13679372 DOI: 10.1074/jbc.M306097200  1
2002 Ottschytsch N, Raes A, Van Hoorick D, Snyders DJ. Obligatory heterotetramerization of three previously uncharacterized Kv channel α-subunits identified in the human genome Proceedings of the National Academy of Sciences of the United States of America. 99: 7986-7991. PMID 12060745 DOI: 10.1073/pnas.122617999  1
2002 Rich TC, Yeola SW, Tamkun MM, Snyders DJ. Mutations throughout the S6 region of the hKv1.5 channel alter the stability of the activation gate. American Journal of Physiology. Cell Physiology. 282: C161-71. PMID 11742809 DOI: 10.1152/ajpcell.00232.2001  1
2000 Longobardo M, González T, Navarro-Polanco R, Caballero R, Delpón E, Tamargo J, Snyders DJ, Tamkun MM, Valenzuela C. Effects of a quaternary bupivacaine derivative on delayed rectifier K(+) currents. British Journal of Pharmacology. 130: 391-401. PMID 10807678 DOI: 10.1038/sj.bjp.0703334  1
1999 Franqueza L, Valenzuela C, Eck J, Tamkun MM, Tamargo J, Snyders DJ. Functional expression of an inactivating potassium channel (Kv4.3) in a mammalian cell line. Cardiovascular Research. 41: 212-9. PMID 10325968 DOI: 10.1016/S0008-6363(98)00220-X  1
1997 Franqueza L, Longobardo M, Vicente J, Delpón E, Tamkun MM, Tamargo J, Snyders DJ, Valenzuela C. Molecular determinants of stereoselective bupivacaine block of hKv1.5 channels. Circulation Research. 81: 1053-64. PMID 9400387 DOI: 10.1161/01.RES.81.6.1053  1
1996 Yeola SW, Rich TC, Uebele VN, Tamkun MM, Snyders DJ. Molecular analysis of a binding site for quinidine in a human cardiac delayed rectifier K+ channel. Role of S6 in antiarrhythmic drug binding. Circulation Research. 78: 1105-14. PMID 8635242 DOI: 10.1161/01.RES.78.6.1105  1
1996 Uebele VN, England SK, Chaudhary A, Tamkun MM, Snyders DJ. Functional differences in Kv1.5 currents expressed in mammalian cell lines are due to the presence of endogenous Kv beta 2.1 subunits. The Journal of Biological Chemistry. 271: 2406-12. PMID 8576199 DOI: 10.1074/jbc.271.5.2406  1
1995 Valenzuela C, Delpón E, Tamkun MM, Tamargo J, Snyders DJ. Stereoselective block of a human cardiac potassium channel (Kv1.5) by bupivacaine enantiomers. Biophysical Journal. 69: 418-27. PMID 8527655 DOI: 10.1016/S0006-3495(95)79914-3  1
1994 Uebele VN, Yeola SW, Snyders DJ, Tamkun MM. Deletion of highly conserved C-terminal sequences in the Kv1 K+ channel sub-family does not prevent expression of currents with wild-type characteristics. Febs Letters. 340: 104-8. PMID 8119390 DOI: 10.1016/0014-5793(94)80181-9  1
1994 Murray KT, Fahrig SA, Deal KK, Po SS, Hu NN, Snyders DJ, Tamkun MM, Bennett PB. Modulation of an inactivating human cardiac K+ channel by protein kinase C. Circulation Research. 75: 999-1005. PMID 7955154 DOI: 10.1161/01.RES.75.6.999  1
1994 Felipe A, Knittle TJ, Doyle KL, Snyders DJ, Tamkun MM. Differential expression of Isk mRNAs in mouse tissue during development and pregnancy. The American Journal of Physiology. 267: C700-5. PMID 7943198 DOI: 10.1152/AJPCELL.1994.267.3.C700  1
1994 Yang T, Wathen MS, Felipe A, Tamkun MM, Snyders DJ, Roden DM. K+ currents and K+ channel mRNA in cultured atrial cardiac myocytes (AT-1 cells). Circulation Research. 75: 870-8. PMID 7923633 DOI: 10.1161/01.RES.75.5.870  1
1993 Snyders DJ, Tamkun MM, Bennett PB. A rapidly activating and slowly inactivating potassium channel cloned from human heart. Functional analysis after stable mammalian cell culture expression. The Journal of General Physiology. 101: 513-43. PMID 8505626 DOI: 10.1085/jgp.101.4.513  1
1993 Po S, Roberds S, Snyders DJ, Tamkun MM, Bennett PB. Heteromultimeric assembly of human potassium channels. Molecular basis of a transient outward current? Circulation Research. 72: 1326-36. PMID 8495559 DOI: 10.1161/01.RES.72.6.1326  1
1993 Roberds SL, Knoth KM, Po S, Blair TA, Bennett PB, Hartshorne RP, Snyders DJ, Tamkun MM. Molecular biology of the voltage-gated potassium channels of the cardiovascular system. Journal of Cardiovascular Electrophysiology. 4: 68-80. PMID 8287238 DOI: 10.1111/j.1540-8167.1993.tb01214.x  1
1993 Felipe A, Snyders DJ, Deal KK, Tamkun MM. Influence of cloned voltage-gated K+ channel expression on alanine transport, Rb+ uptake, and cell volume. The American Journal of Physiology. 265: C1230-8. PMID 8238476 DOI: 10.1152/ajpcell.1993.265.5.C1230  1
1993 Bennett PB, Po S, Snyders DJ, Tamkun MM. Molecular and functional diversity of cloned cardiac potassium channels. Cardiovascular Drugs and Therapy / Sponsored by the International Society of Cardiovascular Pharmacotherapy. 7: 585-92. PMID 7504512 DOI: 10.1007/BF00877624  1
1992 Po S, Snyders DJ, Baker R, Tamkun MM, Bennett PB. Functional expression of an inactivating potassium channel cloned from human heart. Circulation Research. 71: 732-6. PMID 1499114 DOI: 10.1161/01.RES.71.3.732  1
1989 Johns JA, Anno T, Bennett PB, Snyders DJ, Hondeghem LM. Temperature and voltage dependence of sodium channel blocking and unblocking by O-demethyl encainide in isolated guinea pig myocytes. Journal of Cardiovascular Pharmacology. 13: 826-35. PMID 2484076 DOI: 10.1097/00005344-198906000-00004  1
1988 Roden DM, Bennett PB, Snyders DJ, Balser JR, Hondeghem LM. Quinidine delays I(K) activation in guinea pig ventricular myocytes Circulation Research. 62: 1055-1058. PMID 2452034 DOI: 10.1161/01.RES.62.5.1055  1
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