Donald J. Creighton - Publications

Affiliations: 
Biochemistry University of Maryland, Baltimore County 
Area:
Biochemistry, Pharmacology

42 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Sang Y, Shi Q, Mo M, Ni C, Li Z, Liu B, Deng Q, Creighton DJ, Zheng ZB. Novel bivalent inhibitors with sub-nanomolar affinities towards human glyoxalase I. Bioorganic & Medicinal Chemistry Letters. 25: 4724-7. PMID 26320622 DOI: 10.1016/J.Bmcl.2015.08.055  0.32
2014 Holewinski RJ, Creighton DJ. Inhibition by active site directed covalent modification of human glyoxalase I. Bioorganic & Medicinal Chemistry. 22: 3301-8. PMID 24856185 DOI: 10.1016/J.Bmc.2014.04.055  0.32
2005 Joseph E, Ganem B, Eiseman JL, Creighton DJ. Selective inhibition of MCF-7(piGST) breast tumors using glutathione transferase-derived 2-methylene-cycloalkenones. Journal of Medicinal Chemistry. 48: 6549-52. PMID 16220971 DOI: 10.1021/Jm058245F  0.32
2005 Zheng ZB, Zhu G, Tak H, Joseph E, Eiseman JL, Creighton DJ. N-(2-hydroxypropyl)methacrylamide copolymers of a glutathione (GSH)-activated glyoxalase i inhibitor and DNA alkylating agent: synthesis, reaction kinetics with GSH, and in vitro antitumor activities. Bioconjugate Chemistry. 16: 598-607. PMID 15898727 DOI: 10.1021/Bc0499634  0.32
2005 Akoachere M, Iozef R, Rahlfs S, Deponte M, Mannervik B, Creighton DJ, Schirmer H, Becker K. Characterization of the glyoxalases of the malarial parasite Plasmodium falciparum and comparison with their human counterparts. Biological Chemistry. 386: 41-52. PMID 15843146 DOI: 10.1515/Bc.2005.006  0.32
2003 Hamilton DS, Zhang X, Ding Z, Hubatsch I, Mannervik B, Houk KN, Ganem B, Creighton DJ. Mechanism of the glutathione transferase-catalyzed conversion of antitumor 2-crotonyloxymethyl-2-cycloalkenones to GSH adducts. Journal of the American Chemical Society. 125: 15049-58. PMID 14653739 DOI: 10.1021/Ja030396P  0.32
2003 Zheng ZB, Creighton DJ. Bivalent transition-state analogue inhibitors of human glyoxalase I. Organic Letters. 5: 4855-8. PMID 14653691 DOI: 10.1021/Ol035917S  0.32
2003 Creighton DJ, Zheng ZB, Holewinski R, Hamilton DS, Eiseman JL. Glyoxalase I inhibitors in cancer chemotherapy Biochemical Society Transactions. 31: 1378-1382. PMID 14641067 DOI: 10.1042/Bst0311378  0.32
2003 Joseph E, Eiseman JL, Hamilton DS, Wang H, Tak H, Ding Z, Ganem B, Creighton DJ. Molecular basis of the antitumor activities of 2-crotonyloxymethyl-2-cycloalkenones. Journal of Medicinal Chemistry. 46: 194-6. PMID 12502374 DOI: 10.1021/Jm0203027  0.32
2002 Zhang Q, Ding Z, Creighton DJ, Ganem B, Fabris D. Alkylation of nucleic acids by the antitumor agent COMC. Organic Letters. 4: 1459-62. PMID 11975603 DOI: 10.1021/Ol025612Y  0.32
2002 Hamilton DS, Ding Z, Ganem B, Creighton DJ. Glutathionyl transferase catalyzed addition of glutathione to COMC: a new hypothesis for antitumor activity. Organic Letters. 4: 1209-12. PMID 11922820 DOI: 10.1021/Ol025650H  0.32
2001 Creighton DJ, Hamilton DS. Brief history of glyoxalase I and what we have learned about metal ion-dependent, enzyme-catalyzed isomerizations. Archives of Biochemistry and Biophysics. 387: 1-10. PMID 11368170 DOI: 10.1006/Abbi.2000.2253  0.32
2000 Kalsi A, Kavarana MJ, Lu T, Whalen DL, Hamilton DS, Creighton DJ. Role of hydrophobic interactions in binding S-(N-aryl/alkyl-N-hydroxycarbamoyl)glutathiones to the active site of the antitumor target enzyme glyoxalase I. Journal of Medicinal Chemistry. 43: 3981-6. PMID 11052803 DOI: 10.1021/Jm000160L  0.32
2000 Huntley CF, Hamilton DS, Creighton DJ, Ganem B. Reaction of COTC with glutathione: structure of the putative glyoxalase I inhibitor. Organic Letters. 2: 3143-4. PMID 11009366 DOI: 10.1021/ol006341z  0.32
2000 Sharkey EM, O'Neill HB, Kavarana MJ, Wang H, Creighton DJ, Sentz DL, Eiseman JL. Pharmacokinetics and antitumor properties in tumor-bearing mice of an enediol analogue inhibitor of glyoxalase I Cancer Chemotherapy and Pharmacology. 46: 156-166. PMID 10972486 DOI: 10.1007/S002800000130  0.32
1999 Cameron AD, Ridderström M, Olin B, Kavarana MJ, Creighton DJ, Mannervik B. Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue. Biochemistry. 38: 13480-90. PMID 10521255 DOI: 10.1021/Bi990696C  0.32
1999 Tencza SB, Creighton DJ, Yuan T, Vogel HJ, Montelaro RC, Mietzner TA. Lentivirus-derived antimicrobial peptides: Increased potency by sequence engineering and dimerization Journal of Antimicrobial Chemotherapy. 44: 33-41. PMID 10459808 DOI: 10.1093/Jac/44.1.33  0.32
1999 Hamilton DS, Kavarana MJ, Sharkey EM, Eiseman JL, Creighton DJ. A new method for rapidly generating inhibitors of glyoxalase I inside tumor cells using S-(N-aryl-N-hydroxycarbamoyl)ethylsulfoxides Journal of Medicinal Chemistry. 42: 1823-1827. PMID 10346934 DOI: 10.1021/Jm980712O  0.32
1999 Kavarana MJ, Kovaleva EG, Creighton DJ, Wollman MB, Eiseman JL. Mechanism-based competitive inhibitors of glyoxalase I: Intracellular delivery, in vitro antitumor activities, and stabilities in human serum and mouse serum Journal of Medicinal Chemistry. 42: 221-228. PMID 9925727 DOI: 10.1021/Jm9708036  0.32
1998 Saint-Jean AP, Phillips KR, Creighton DJ, Stone MJ. Active monomeric and dimeric forms of Pseudomonas putida glyoxalase I: evidence for 3D domain swapping. Biochemistry. 37: 10345-53. PMID 9671502 DOI: 10.1021/Bi980868Q  0.32
1997 Tencza SB, Douglass JP, Creighton DJ, Montelaro RC, Mietzner TA. Novel antimicrobial peptides derived from human immunodeficiency virus type 1 and other lentivirus transmembrane proteins Antimicrobial Agents and Chemotherapy. 41: 2394-2398. PMID 9371339 DOI: 10.1128/Aac.41.11.2394  0.32
1997 Shih MJ, Edinger JW, Creighton DJ. Diffusion-dependent kinetic properties of glyoxalase I and estimates of the steady-state concentrations of glyoxalase-pathway intermediates in glycolyzing erythrocytes. European Journal of Biochemistry / Febs. 244: 852-7. PMID 9108256 DOI: 10.1111/J.1432-1033.1997.00852.X  0.32
1995 Lan Y, Lu T, Lovett PS, Creighton DJ. Evidence for a (triosephosphate isomerase-like) "catalytic loop" near the active site of glyoxalase I. The Journal of Biological Chemistry. 270: 12957-60. PMID 7768882 DOI: 10.1074/Jbc.270.22.12957  0.32
1994 Murthy NSRK, Bakeris T, Kavarana MJ, Hamilton DS, Lan Y, Creighton DJ. S-(N-Aryl-N-hydroxycarbamoyl)glutathione derivatives are tight-binding inhibitors of glyoxalase I and slow substrates for glyoxalase II Journal of Medicinal Chemistry. 37: 2161-2166. PMID 8035422 DOI: 10.1021/Jm00040A007  0.32
1994 Lu T, Creighton DJ, Antoine M, Fenselau C, Lovett PS. The gene encoding glyoxalase I from Pseudomonas putida: cloning, overexpression, and sequence comparisons with human glyoxalase I Gene. 150: 93-96. PMID 7959071 DOI: 10.1016/0378-1119(94)90864-8  0.32
1992 Hamilton DS, Creighton DJ. Caution: the glycylmethyl and glycylethyl esters of glutathione are substrates for glyoxalase I. Biochimica Et Biophysica Acta. 1159: 203-8. PMID 1390924 DOI: 10.1016/0167-4838(92)90026-A  0.32
1991 Xie X, Creighton DJ. Synthesis and initial characterization of γ-L-glutamyl-L-thiothreonyl-glycine and γ-L-glutamyl-L-allo-thiothreonylglycine as steric probes of the active site of glyoxalase I Biochemical and Biophysical Research Communications. 177: 252-258. PMID 2043110 DOI: 10.1016/0006-291X(91)91975-I  0.32
1991 Li J, Guha MK, Creighton DJ. Enzyme chemistry of dithiohemiacetals: synthesis and characterization of S-D-dithiomandeloylglutathione as an alternate substrate for glyoxalase I. Biochemical and Biophysical Research Communications. 181: 657-63. PMID 1755849 DOI: 10.1016/0006-291X(91)91241-4  0.32
1990 Creighton DJ, Murthy NSRK. 7 Stereochemistry of Enzyme -Catalyzed Reactions at Carbon Enzymes. 19: 323-421. DOI: 10.1016/S1874-6047(08)60200-0  0.32
1988 Creighton DJ, Migliorini M, Pourmotabbed T, Guha MK. Optimization of efficiency in the glyoxalase pathway. Biochemistry. 27: 7376-84. PMID 3207683 DOI: 10.1021/Bi00419A031  0.32
1986 Migliorini M, Creighton DJ. Active-site ionizations of papain. An evaluation of the potentiometric difference titration method European Journal of Biochemistry / Febs. 156: 189-192. PMID 3007141 DOI: 10.1111/J.1432-1033.1986.Tb09566.X  0.32
1983 Griffis CEF, Ong LH, Buettner L, Creighton DJ. Nonstereospecific substrate usage by glyoxalase I Biochemistry. 22: 2945-2951. PMID 6347254 DOI: 10.1021/Bi00281A025  0.32
1980 Wandinger A, Creighton DJ. Solvent isotope effects on the rates of alkylation of thiolamine models of papain Febs Letters. 116: 116-121. PMID 7409133 DOI: 10.1016/0014-5793(80)80541-2  0.32
1980 Creighton DJ, Gessouroun MS, Heapes JM. Is the thiolate-imidazolium ion pair the catalytically important form of papain? Febs Letters. 110: 319-322. PMID 7371836 DOI: 10.1016/0014-5793(80)80101-3  0.32
1980 Creighton DJ, Schamp DJ. Solvent isotope effects on tautomerization equilibria of papain and model thiolamines Febs Letters. 110: 313-318. PMID 7371835 DOI: 10.1016/0014-5793(80)80100-1  0.32
1980 Welsh KM, Creighton DJ, Klinman JP. Transition-state structure in the yeast alcohol dehydrogenase reaction: the magnitude of solvent and alpha-secondary hydrogen isotope effects. Biochemistry. 19: 2005-16. PMID 6990968 DOI: 10.1021/Bi00551A001  0.32
1980 Creighton DJ, Weiner A, Buettner L. Hydrophobic binding is not an independent stereochemical determinant in the yeast glyoxalase I reaction Biophysical Chemistry. 11: 265-269. PMID 6989412 DOI: 10.1016/0301-4622(80)80029-9  0.32
1978 Frolich M, Creighton DJ, Sigman DS. Limiting rates of ligand association to alcohol dehydrogenase Archives of Biochemistry and Biophysics. 189: 471-480. PMID 213026 DOI: 10.1016/0003-9861(78)90236-9  0.32
1976 Creighton DJ, Hajdu J, Sigman DS. Model dehydrogenase reactions. Zinc ion catalyzed reduction of chelating aldehydes by N-propyl-1,4-dihydronicotinamides and borohydride Journal of the American Chemical Society. 98: 4619-4625. PMID 132467 DOI: 10.1021/Ja00431A047  0.32
1973 Creighton DJ. Model dehydrogenase reactions. Reduction of N-methylacridinium ion by reduced nicotinamide adenine dinucleotide and its derivatives [20] Journal of the American Chemical Society. 95: 6855-6857. PMID 4147716 DOI: 10.1021/Ja00801A067  0.32
1972 Sigman DS, Wahl GM, Creighton DJ. Models for metalloenzymes. Zinc ion catalyzed phosphorylation of 1,10-phenanthroline-2-carbinol by adenosine triphosphate Biochemistry. 11: 2236-2242. PMID 5028493 DOI: 10.1021/Bi00762A005  0.32
1971 Creighton DJ, Sigman DS. A model for alcohol dehydrogenase. The zinc ion catalyzed reduction of 1,10-phenanthroline-2-carboxaldehyde by N-propyl-1,4-dihydronicotinamide [36] Journal of the American Chemical Society. 93: 6314-6316. PMID 4256338 DOI: 10.1021/Ja00752A079  0.32
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