Nouri Neamati - Publications

Affiliations: 
Pharmacy University of Michigan, Ann Arbor, Ann Arbor, MI 
 2000- Pharmaceutical Sciences University of Southern California, Los Angeles, CA, United States 
Area:
Pharmacology, Biochemistry
Website:
https://pharmacy.umich.edu/people/neamati

140 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Xu S, Liu Y, Yang K, Wang H, Shergalis A, Kyani A, Bankhead A, Tamura S, Yang S, Wang X, Wang CC, Rehemtulla A, Ljungman M, Neamati N. Inhibition of protein disulfide isomerase in glioblastoma causes marked downregulation of DNA repair and DNA damage response genes. Theranostics. 9: 2282-2298. PMID 31149044 DOI: 10.7150/thno.30621  0.84
2018 Huddle BC, Grimley E, Buchman CD, Chtcherbinine M, Debnath B, Mehta P, Yang K, Morgan CA, Li S, Felton JA, Sun D, Metha G, Neamati N, Buckanovich RJ, Hurley TD, et al. Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy. Journal of Medicinal Chemistry. PMID 30221940 DOI: 10.1021/acs.jmedchem.8b00930  0.6
2018 Dai W, Chen W, Debnath B, Yong W, Neamati N. Synthesis, Structure-activity Relationship Studies and ADMET Properties of 3-aminocyclohex-2-en-1-ones as Chemokine Receptor 2 (CXCR2) Antagonists. Chemmedchem. PMID 29493096 DOI: 10.1002/cmdc.201800027  0.6
2018 Kuang Y, Sechi M, Nurra S, Ljungman M, Neamati N. Design and Synthesis of Novel Reactive Oxygen Species Inducers for the Treatment of Pancreatic Ductal Adenocarcinoma. Journal of Medicinal Chemistry. PMID 29328656 DOI: 10.1021/acs.jmedchem.7b01463  0.52
2017 Kyani A, Tamura S, Yang S, Shergalis A, Samanta S, Kuang Y, Ljungman M, Neamati N. Discovery and Mechanistic Elucidation of a Class of Protein Disulfide Isomerase Inhibitors for the Treatment of Glioblastoma. Chemmedchem. PMID 29235250 DOI: 10.1002/cmdc.201700629  0.52
2017 Mehanna WE, Lu T, Debnath B, Lasheen DS, Serya RAT, Abouzid KA, Neamati N. Synthesis, ADMET properties, and biological evaluation of benzothiazole compounds targeting CXCR2. Chemmedchem. PMID 28544630 DOI: 10.1002/cmdc.201700229  0.6
2017 Ha H, Debnath B, Neamati N. Role of the CXCL8-CXCR1/2 Axis in Cancer and Inflammatory Diseases. Theranostics. 7: 1543-1588. PMID 28529637 DOI: 10.7150/thno.15625  0.68
2016 Zhang FH, Debnath B, Xu ZL, Yang LM, Song LR, Zheng YT, Neamati N, Long YQ. Discovery of novel 3-hydroxypicolinamides as selective inhibitors of HIV-1 integrase-LEDGF/p75 interaction. European Journal of Medicinal Chemistry. 125: 1051-1063. PMID 27810592 DOI: 10.1016/j.ejmech.2016.10.045  0.6
2016 Ramkumar K, Samanta S, Kyani A, Yang S, Tamura S, Ziemke E, Stuckey JA, Li S, Chinnaswamy K, Otake H, Debnath B, Yarovenko V, Sebolt-Leopold JS, Ljungman M, Neamati N. Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor. Nature Communications. 7: 13084. PMID 27703239 DOI: 10.1038/ncomms13084  1
2016 Sanna V, Nurra S, Pala N, Marceddu S, Pathania D, Neamati N, Sechi M. Targeted Nanoparticles for the Delivery of Novel Bioactive Molecules to Pancreatic Cancer Cells. Journal of Medicinal Chemistry. PMID 27139920 DOI: 10.1021/acs.jmedchem.5b01571  1
2016 Grande F, Aiello F, Garofalo A, Neamati N. Identification and Preclinical Evaluation of SC144, a Novel Pyrroloquinoxaline Derivative with Broad-Spectrum Anticancer Activity. Mini Reviews in Medicinal Chemistry. 16: 644-50. PMID 26955877  0.76
2015 Kuang Y, El-Khoueiry A, Taverna P, Ljungman M, Neamati N. Guadecitabine (SGI-110) priming sensitizes hepatocellular carcinoma cells to oxaliplatin. Molecular Oncology. PMID 26160429 DOI: 10.1016/j.molonc.2015.06.002  0.52
2015 Ha H, Debnath B, Odde S, Bensman T, Ho H, Beringer PM, Neamati N. Discovery of Novel CXCR2 Inhibitors Using Ligand-Based Pharmacophore Models. Journal of Chemical Information and Modeling. 55: 1720-38. PMID 26153616 DOI: 10.1021/acs.jcim.5b00181  0.6
2015 Xu S, Adisetiyo H, Tamura S, Grande F, Garofalo A, Roy-Burman P, Neamati N. Dual inhibition of survivin and MAOA synergistically impairs growth of PTEN-negative prostate cancer. British Journal of Cancer. 113: 242-51. PMID 26103574 DOI: 10.1038/bjc.2015.228  1
2015 Aboye T, Kuang Y, Neamati N, Camarero JA. Rapid parallel synthesis of bioactive folded cyclotides by using a tea-bag approach. Chembiochem : a European Journal of Chemical Biology. 16: 827-33. PMID 25663016 DOI: 10.1002/cbic.201402691  1
2015 Pathania D, Kuang Y, Sechi M, Neamati N. Mechanisms underlying the cytotoxicity of a novel quinazolinedione-based redox modulator, QD232, in pancreatic cancer cells. British Journal of Pharmacology. 172: 50-63. PMID 25047070 DOI: 10.1111/bph.12855  1
2014 Kumar BV, Lakshmi N, Kumar MR, Rambabu G, Manjashetty TH, Arunasree KM, Sriram D, Ramkumar K, Neamati N, Dayam R, Sarma JA. Design, synthesis and screening studies of potent thiazol-2-amine derivatives as fibroblast growth factor receptor 1 inhibitors. Current Topics in Medicinal Chemistry. 14: 2031-41. PMID 25322771  0.72
2014 Singh SS, Sarma JA, Narasu L, Dayam R, Xu S, Neamati N. A review on PARP1 inhibitors: Pharmacophore modeling, virtual and biological screening studies to identify novel PARP1 inhibitors. Current Topics in Medicinal Chemistry. 14: 2020-30. PMID 25262797  0.84
2014 Zhang D, Debnath B, Yu S, Sanchez TW, Christ F, Liu Y, Debyser Z, Neamati N, Zhao G. Design and discovery of 5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxamide inhibitors of HIV-1 integrase. Bioorganic & Medicinal Chemistry. 22: 5446-53. PMID 25150089 DOI: 10.1016/j.bmc.2014.07.036  1
2014 Ha H, Neamati N. Pyrimidine-based compounds modulate CXCR2-mediated signaling and receptor turnover. Molecular Pharmaceutics. 11: 2431-41. PMID 24896229 DOI: 10.1021/mp500180e  1
2014 Li BW, Zhang FH, Serrao E, Chen H, Sanchez TW, Yang LM, Neamati N, Zheng YT, Wang H, Long YQ. Design and discovery of flavonoid-based HIV-1 integrase inhibitors targeting both the active site and the interaction with LEDGF/p75. Bioorganic & Medicinal Chemistry. 22: 3146-58. PMID 24794743 DOI: 10.1016/j.bmc.2014.04.016  1
2014 Rogolino D, Carcelli M, Compari C, De Luca L, Ferro S, Fisicaro E, Rispoli G, Neamati N, Debyser Z, Christ F, Chimirri A. Diketoacid chelating ligands as dual inhibitors of HIV-1 integration process. European Journal of Medicinal Chemistry. 78: 425-30. PMID 24704615 DOI: 10.1016/j.ejmech.2014.03.070  1
2014 Jali BR, Kuang Y, Neamati N, Baruah JB. Selective binding of naphthoquinone derivatives to serum albumin proteins and their effects on cytotoxicity. Chemico-Biological Interactions. 214: 10-7. PMID 24560625 DOI: 10.1016/j.cbi.2014.01.014  1
2014 Serrao E, Wang CH, Frederick T, Lee CL, Anthony P, Arribas-Layton D, Baker K, Millstein J, Kovacs A, Neamati N. Alteration of select gene expression patterns in individuals infected with HIV-1. Journal of Medical Virology. 86: 678-86. PMID 24482297 DOI: 10.1002/jmv.23872  0.48
2014 Xu S, Sankar S, Neamati N. Protein disulfide isomerase: a promising target for cancer therapy. Drug Discovery Today. 19: 222-40. PMID 24184531 DOI: 10.1016/j.drudis.2013.10.017  0.84
2014 Pathania D, Sechi M, Palomba M, Sanna V, Berrettini F, Sias A, Taheri L, Neamati N. Design and discovery of novel quinazolinedione-based redox modulators as therapies for pancreatic cancer. Biochimica Et Biophysica Acta. 1840: 332-43. PMID 23954204 DOI: 10.1016/j.bbagen.2013.08.005  1
2013 Millard M, Gallagher JD, Olenyuk BZ, Neamati N. A selective mitochondrial-targeted chlorambucil with remarkable cytotoxicity in breast and pancreatic cancers. Journal of Medicinal Chemistry. 56: 9170-9. PMID 24147900 DOI: 10.1021/jm4012438  1
2013 Kim K, Kim JM, Kim JS, Choi J, Lee YS, Neamati N, Song JS, Heo K, An W. VprBP has intrinsic kinase activity targeting histone H2A and represses gene transcription. Molecular Cell. 52: 459-67. PMID 24140421 DOI: 10.1016/j.molcel.2013.09.017  1
2013 Xu S, Neamati N. gp130: a promising drug target for cancer therapy. Expert Opinion On Therapeutic Targets. 17: 1303-28. PMID 24099136 DOI: 10.1517/14728222.2013.830105  0.84
2013 Sharma H, Sanchez TW, Neamati N, Detorio M, Schinazi RF, Cheng X, Buolamwini JK. Synthesis, docking, and biological studies of phenanthrene β-diketo acids as novel HIV-1 integrase inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 6146-51. PMID 24091080 DOI: 10.1016/j.bmcl.2013.09.009  1
2013 Yu S, Sanchez TW, Liu Y, Yin Y, Neamati N, Zhao G. Design and synthesis of novel pyrimidone analogues as HIV-1 integrase inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 6134-7. PMID 24084160 DOI: 10.1016/j.bmcl.2013.09.018  1
2013 Serrao E, Xu ZL, Debnath B, Christ F, Debyser Z, Long YQ, Neamati N. Discovery of a novel 5-carbonyl-1H-imidazole-4-carboxamide class of inhibitors of the HIV-1 integrase-LEDGF/p75 interaction. Bioorganic & Medicinal Chemistry. 21: 5963-72. PMID 23985689 DOI: 10.1016/j.bmc.2013.07.047  1
2013 Adisetiyo H, Liang M, Liao CP, Aycock-Williams A, Cohen MB, Xu S, Neamati N, Conway EM, Cheng CY, Nikitin AY, Roy-Burman P. Loss of survivin in the prostate epithelium impedes carcinogenesis in a mouse model of prostate adenocarcinoma. Plos One. 8: e69484. PMID 23936028 DOI: 10.1371/journal.pone.0069484  1
2013 Saha S, Reddy ChV, Xu S, Sankar S, Neamati N, Patro B. Synthesis and SAR studies of marine natural products ma'edamines A, B and their analogues. Bioorganic & Medicinal Chemistry Letters. 23: 5135-9. PMID 23927972 DOI: 10.1016/j.bmcl.2013.07.017  0.84
2013 Ji Y, Majumder S, Millard M, Borra R, Bi T, Elnagar AY, Neamati N, Shekhtman A, Camarero JA. In vivo activation of the p53 tumor suppressor pathway by an engineered cyclotide. Journal of the American Chemical Society. 135: 11623-33. PMID 23848581 DOI: 10.1021/ja405108p  1
2013 Long YQ, Huang SX, Zawahir Z, Xu ZL, Li H, Sanchez TW, Zhi Y, De Houwer S, Christ F, Debyser Z, Neamati N. Design of cell-permeable stapled peptides as HIV-1 integrase inhibitors. Journal of Medicinal Chemistry. 56: 5601-12. PMID 23758584 DOI: 10.1021/jm4006516  1
2013 Xu S, Grande F, Garofalo A, Neamati N. Discovery of a novel orally active small-molecule gp130 inhibitor for the treatment of ovarian cancer. Molecular Cancer Therapeutics. 12: 937-49. PMID 23536726 DOI: 10.1158/1535-7163.MCT-12-1082  1
2013 Xu S, Oshima T, Imada T, Masuda M, Debnath B, Grande F, Garofalo A, Neamati N. Stabilization of MDA-7/IL-24 for colon cancer therapy. Cancer Letters. 335: 421-30. PMID 23481022 DOI: 10.1016/j.canlet.2013.02.055  1
2013 Serrao E, Debnath B, Otake H, Kuang Y, Christ F, Debyser Z, Neamati N. Fragment-based discovery of 8-hydroxyquinoline inhibitors of the HIV-1 integrase-lens epithelium-derived growth factor/p75 (IN-LEDGF/p75) interaction. Journal of Medicinal Chemistry. 56: 2311-22. PMID 23445471 DOI: 10.1021/jm301632e  1
2013 Debnath B, Xu S, Grande F, Garofalo A, Neamati N. Small molecule inhibitors of CXCR4. Theranostics. 3: 47-75. PMID 23382786 DOI: 10.7150/thno.5376  1
2013 Shabaik YH, Millard M, Neamati N. Mechanistic evaluation of a novel small molecule targeting mitochondria in pancreatic cancer cells. Plos One. 8: e54346. PMID 23349858 DOI: 10.1371/journal.pone.0054346  1
2013 Sanchez TW, Debnath B, Christ F, Otake H, Debyser Z, Neamati N. Discovery of novel inhibitors of LEDGF/p75-IN protein-protein interactions. Bioorganic & Medicinal Chemistry. 21: 957-63. PMID 23306052 DOI: 10.1016/j.bmc.2012.12.012  1
2013 Carcelli M, Bacchi A, Pelagatti P, Rispoli G, Rogolino D, Sanchez TW, Sechi M, Neamati N. Ruthenium arene complexes as HIV-1 integrase strand transfer inhibitors. Journal of Inorganic Biochemistry. 118: 74-82. PMID 23123342 DOI: 10.1016/j.jinorgbio.2012.09.021  1
2012 Aboye TL, Ha H, Majumder S, Christ F, Debyser Z, Shekhtman A, Neamati N, Camarero JA. Design of a novel cyclotide-based CXCR4 antagonist with anti-human immunodeficiency virus (HIV)-1 activity. Journal of Medicinal Chemistry. 55: 10729-34. PMID 23151033 DOI: 10.1021/jm301468k  1
2012 Zeng LF, Wang Y, Kazemi R, Xu S, Xu ZL, Sanchez TW, Yang LM, Debnath B, Odde S, Xie H, Zheng YT, Ding J, Neamati N, Long YQ. Repositioning HIV-1 integrase inhibitors for cancer therapeutics: 1,6-naphthyridine-7-carboxamide as a promising scaffold with drug-like properties. Journal of Medicinal Chemistry. 55: 9492-509. PMID 23098137 DOI: 10.1021/jm300667v  1
2012 Serrao E, Thys W, Demeulemeester J, Al-Mawsawi LQ, Christ F, Debyser Z, Neamati N. A symmetric region of the HIV-1 integrase dimerization interface is essential for viral replication. Plos One. 7: e45177. PMID 23028829 DOI: 10.1371/journal.pone.0045177  1
2012 Xu S, Butkevich AN, Yamada R, Zhou Y, Debnath B, Duncan R, Zandi E, Petasis NA, Neamati N. Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment. Proceedings of the National Academy of Sciences of the United States of America. 109: 16348-53. PMID 22988091 DOI: 10.1073/pnas.1205226109  1
2012 Aiello F, Shabaik Y, Esqueda A, Sanchez TW, Grande F, Garofalo A, Neamati N. Design and synthesis of 3-carbamoylbenzoic acid derivatives as inhibitors of human apurinic/apyrimidinic endonuclease 1 (APE1). Chemmedchem. 7: 1825-39. PMID 22952012 DOI: 10.1002/cmdc.201200334  1
2012 Debnath B, Xu S, Neamati N. Small molecule inhibitors of signal transducer and activator of transcription 3 (Stat3) protein. Journal of Medicinal Chemistry. 55: 6645-68. PMID 22650325 DOI: 10.1021/jm300207s  0.84
2012 Yu S, Zhang L, Yan S, Wang P, Sanchez T, Christ F, Debyser Z, Neamati N, Zhao G. Nitrogen-containing polyhydroxylated aromatics as HIV-1 integrase inhibitors: synthesis, structure-activity relationship analysis, and biological activity. Journal of Enzyme Inhibition and Medicinal Chemistry. 27: 628-40. PMID 22233539 DOI: 10.3109/14756366.2011.604851  1
2012 Yadav MR, Grande F, Chouhan BS, Naik PP, Giridhar R, Garofalo A, Neamati N. Cytotoxic potential of novel 6,7-dimethoxyquinazolines. European Journal of Medicinal Chemistry. 48: 231-43. PMID 22209417 DOI: 10.1016/j.ejmech.2011.12.020  1
2012 Cao B, Wang Y, Ding K, Neamati N, Long YQ. Synthesis of the pyridinyl analogues of dibenzylideneacetone (pyr-dba) via an improved Claisen-Schmidt condensation, displaying diverse biological activities as curcumin analogues. Organic & Biomolecular Chemistry. 10: 1239-45. PMID 22179573 DOI: 10.1039/c1ob06773g  0.4
2012 Al-Safi RI, Odde S, Shabaik Y, Neamati N. Small-molecule inhibitors of APE1 DNA repair function: an overview. Current Molecular Pharmacology. 5: 14-35. PMID 22122462  0.56
2011 Bacchi A, Carcelli M, Compari C, Fisicaro E, Pala N, Rispoli G, Rogolino D, Sanchez TW, Sechi M, Sinisi V, Neamati N. Investigating the role of metal chelation in HIV-1 integrase strand transfer inhibitors. Journal of Medicinal Chemistry. 54: 8407-20. PMID 22066494 DOI: 10.1021/jm200851g  1
2011 Monserrat JP, Al-Safi RI, Tiwari KN, Quentin L, Chabot GG, Vessières A, Jaouen G, Neamati N, Hillard EA. Ferrocenyl chalcone difluoridoborates inhibit HIV-1 integrase and display low activity towards cancer and endothelial cells. Bioorganic & Medicinal Chemistry Letters. 21: 6195-7. PMID 21889342 DOI: 10.1016/j.bmcl.2011.07.078  1
2011 Fan X, Zhang FH, Al-Safi RI, Zeng LF, Shabaik Y, Debnath B, Sanchez TW, Odde S, Neamati N, Long YQ. Design of HIV-1 integrase inhibitors targeting the catalytic domain as well as its interaction with LEDGF/p75: a scaffold hopping approach using salicylate and catechol groups. Bioorganic & Medicinal Chemistry. 19: 4935-52. PMID 21778063 DOI: 10.1016/j.bmc.2011.06.058  1
2011 Millard M, Odde S, Neamati N. Integrin targeted therapeutics. Theranostics. 1: 154-88. PMID 21547158  0.96
2011 Yamada R, Cao X, Butkevich AN, Millard M, Odde S, Mordwinkin N, Gundla R, Zandi E, Louie SG, Petasis NA, Neamati N. Discovery and preclinical evaluation of a novel class of cytotoxic propynoic acid carbamoyl methyl amides (PACMAs). Journal of Medicinal Chemistry. 54: 2902-14. PMID 21443194 DOI: 10.1021/jm101655d  1
2011 Millard M, Pathania D, Grande F, Xu S, Neamati N. Small-molecule inhibitors of p53-MDM2 interaction: the 2006-2010 update. Current Pharmaceutical Design. 17: 536-59. PMID 21391905  1
2011 Sharma H, Patil S, Sanchez TW, Neamati N, Schinazi RF, Buolamwini JK. Synthesis, biological evaluation and 3D-QSAR studies of 3-keto salicylic acid chalcones and related amides as novel HIV-1 integrase inhibitors. Bioorganic & Medicinal Chemistry. 19: 2030-45. PMID 21371895 DOI: 10.1016/j.bmc.2011.01.047  1
2011 Stanford SM, Krishnamurthy D, Falk MD, Messina R, Debnath B, Li S, Liu T, Kazemi R, Dahl R, He Y, Yu X, Chan AC, Zhang ZY, Barrios AM, Woods VL, ... Neamati N, et al. Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells. Journal of Medicinal Chemistry. 54: 1640-54. PMID 21341673 DOI: 10.1021/jm101202j  1
2011 Bacchi A, Carcelli M, Compari C, Fisicaro E, Pala N, Rispoli G, Rogolino D, Sanchez TW, Sechi M, Neamati N. HIV-1 IN strand transfer chelating inhibitors: a focus on metal binding. Molecular Pharmaceutics. 8: 507-19. PMID 21323359 DOI: 10.1021/mp100343x  1
2011 Al-Mawsawi LQ, Neamati N. Allosteric inhibitor development targeting HIV-1 integrase. Chemmedchem. 6: 228-41. PMID 21275045 DOI: 10.1002/cmdc.201000443  1
2010 Debnath B, Al-Mawsawi LQ, Neamati N. Are we living in the end of the blockbuster drug era? Drug News & Perspectives. 23: 670-84. PMID 21180653 DOI: 10.1358/dnp.2010.23.10.1506088  1
2010 Millard M, Pathania D, Shabaik Y, Taheri L, Deng J, Neamati N. Preclinical evaluation of novel triphenylphosphonium salts with broad-spectrum activity. Plos One. 5. PMID 20957228 DOI: 10.1371/journal.pone.0013131  1
2010 Hadi V, Koh YH, Sanchez TW, Barrios D, Neamati N, Jung KW. Development of the next generation of HIV-1 integrase inhibitors: pyrazolone as a novel inhibitor scaffold. Bioorganic & Medicinal Chemistry Letters. 20: 6854-7. PMID 20864343 DOI: 10.1016/j.bmcl.2010.08.057  1
2010 Ramkumar K, Yarovenko VN, Nikitina AS, Zavarzin IV, Krayushkin MM, Kovalenko LV, Esqueda A, Odde S, Neamati N. Design, synthesis and structure-activity studies of rhodanine derivatives as HIV-1 integrase inhibitors. Molecules (Basel, Switzerland). 15: 3958-92. PMID 20657419 DOI: 10.3390/molecules15063958  0.56
2010 Ramkumar K, Serrao E, Odde S, Neamati N. HIV-1 integrase inhibitors: 2007-2008 update. Medicinal Research Reviews. 30: 890-954. PMID 20135632 DOI: 10.1002/med.20194  1
2010 Yamada R, Kostova MB, Anchoori RK, Xu S, Neamati N, Khan SR. Biological evaluation of paclitaxel-peptide conjugates as a model for MMP2-targeted drug delivery. Cancer Biology & Therapy. 9: 192-203. PMID 20023432  0.84
2010 Sanam R, Tajne S, Gundla R, Vadivelan S, Machiraju PK, Dayam R, Narasu L, Jagarlapudi S, Neamati N. Combined pharmacophore and structure-guided studies to identify diverse HSP90 inhibitors. Journal of Molecular Graphics & Modelling. 28: 472-7. PMID 20005756 DOI: 10.1016/j.jmgm.2009.11.002  0.72
2009 Ramkumar K, Neamati N. Raltegravir: The evidence of its therapeutic value in HIV-1 infection. Core Evidence. 4: 131-47. PMID 20694070  0.48
2009 Pathania D, Millard M, Neamati N. Opportunities in discovery and delivery of anticancer drugs targeting mitochondria and cancer cell metabolism. Advanced Drug Delivery Reviews. 61: 1250-75. PMID 19716393 DOI: 10.1016/j.addr.2009.05.010  1
2009 Grande F, Yamada R, Cao X, Aiello F, Garofalo A, Neamati N. Synthesis and biological evaluation of novel hydrazide based cytotoxic agents. Expert Opinion On Investigational Drugs. 18: 555-68. PMID 19388873 DOI: 10.1517/13543780902858815  0.76
2009 Oshima T, Cao X, Grande F, Yamada R, Garofalo A, Louie S, Neamati N. Combination effects of SC144 and cytotoxic anticancer agents. Anti-Cancer Drugs. 20: 312-20. PMID 19322070 DOI: 10.1097/CAD.0b013e328323a7ca  0.76
2009 Cao X, Plasencia C, Kanzaki A, Yang A, Burke TR, Neamati N. Elucidation of the molecular mechanisms of a salicylhydrazide class of compounds by proteomic analysis. Current Cancer Drug Targets. 9: 189-201. PMID 19275759  0.44
2009 Serrao E, Odde S, Ramkumar K, Neamati N. Raltegravir, elvitegravir, and metoogravir: the birth of "me-too" HIV-1 integrase inhibitors. Retrovirology. 6: 25. PMID 19265512 DOI: 10.1186/1742-4690-6-25  1
2009 Plasencia C, Grande F, Oshima T, Cao X, Yamada R, Sanchez T, Aiello F, Garofalo A, Neamati N. Discovery of a novel quinoxalinhydrazide with a broad-spectrum anticancer activity. Cancer Biology & Therapy. 8: 458-65. PMID 19221468  0.76
2009 Sechi M, Carta F, Sannia L, Dallocchio R, Dessì A, Al-Safi RI, Neamati N. Design, synthesis, molecular modeling, and anti-HIV-1 integrase activity of a series of photoactivatable diketo acid-containing inhibitors as affinity probes. Antiviral Research. 81: 267-76. PMID 19135482 DOI: 10.1016/j.antiviral.2008.12.010  0.56
2009 Zawahir Z, Dayam R, Deng J, Pereira C, Neamati N. Pharmacophore guided discovery of small-molecule human apurinic/apyrimidinic endonuclease 1 inhibitors. Journal of Medicinal Chemistry. 52: 20-32. PMID 19072053 DOI: 10.1021/jm800739m  1
2009 Sechi M, Rizzi G, Bacchi A, Carcelli M, Rogolino D, Pala N, Sanchez TW, Taheri L, Dayam R, Neamati N. Design and synthesis of novel dihydroquinoline-3-carboxylic acids as HIV-1 integrase inhibitors. Bioorganic & Medicinal Chemistry. 17: 2925-35. PMID 19026554 DOI: 10.1016/j.bmc.2008.10.088  1
2008 Deng J, Taheri L, Grande F, Aiello F, Garofalo A, Neamati N. Discovery of novel anticancer compounds based on a quinoxalinehydrazine pharmacophore. Chemmedchem. 3: 1677-86. PMID 18985651 DOI: 10.1002/cmdc.200800217  0.76
2008 Bacchi A, Biemmi M, Carcelli M, Carta F, Compari C, Fisicaro E, Rogolino D, Sechi M, Sippel M, Sotriffer CA, Sanchez TW, Neamati N. From ligand to complexes. Part 2. Remarks on human immunodeficiency virus type 1 integrase inhibition by beta-diketo acid metal complexes. Journal of Medicinal Chemistry. 51: 7253-64. PMID 18983138 DOI: 10.1021/jm800893q  1
2008 Sechi M, Azzena U, Delussu MP, Dallocchio R, Dessì A, Cosseddu A, Pala N, Neamati N. Design and synthesis of bis-amide and hydrazide-containing derivatives of malonic acid as potential HIV-1 integrase inhibitors. Molecules (Basel, Switzerland). 13: 2442-61. PMID 18830166 DOI: 10.3390/molecules13102442  1
2008 Ramkumar K, Tambov KV, Gundla R, Manaev AV, Manaev AV, Yarovenko V, Traven VF, Neamati N. Discovery of 3-acetyl-4-hydroxy-2-pyranone derivatives and their difluoridoborate complexes as a novel class of HIV-1 integrase inhibitors. Bioorganic & Medicinal Chemistry. 16: 8988-98. PMID 18805696 DOI: 10.1016/j.bmc.2008.08.067  0.48
2008 Wilson PM, Fazzone W, LaBonte MJ, Deng J, Neamati N, Ladner RD. Novel opportunities for thymidylate metabolism as a therapeutic target. Molecular Cancer Therapeutics. 7: 3029-37. PMID 18790783 DOI: 10.1158/1535-7163.MCT-08-0280  1
2008 Zeng LF, Zhang HS, Wang YH, Sanchez T, Zheng YT, Neamati N, Long YQ. Efficient synthesis and utilization of phenyl-substituted heteroaromatic carboxylic acids as aryl diketo acid isosteres in the design of novel HIV-1 integrase inhibitors. Bioorganic & Medicinal Chemistry Letters. 18: 4521-4. PMID 18662877 DOI: 10.1016/j.bmcl.2008.07.047  0.4
2008 Zeng LF, Jiang XH, Sanchez T, Zhang HS, Dayam R, Neamati N, Long YQ. Novel dimeric aryldiketo containing inhibitors of HIV-1 integrase: effects of the phenyl substituent and the linker orientation. Bioorganic & Medicinal Chemistry. 16: 7777-87. PMID 18644730 DOI: 10.1016/j.bmc.2008.07.008  0.72
2008 Al-Mawsawi LQ, Al-Safi RI, Neamati N. Anti-infectives: clinical progress of HIV-1 integrase inhibitors. Expert Opinion On Emerging Drugs. 13: 213-25. PMID 18537517 DOI: 10.1517/14728214.13.2.213  1
2008 Al-Mawsawi LQ, Hombrouck A, Dayam R, Debyser Z, Neamati N. Four-tiered π interaction at the dimeric interface of HIV-1 integrase critical for DNA integration and viral infectivity Virology. 377: 355-363. PMID 18514248 DOI: 10.1016/j.virol.2008.04.030  1
2008 Gundla R, Kazemi R, Sanam R, Muttineni R, Sarma JA, Dayam R, Neamati N. Discovery of novel small-molecule inhibitors of human epidermal growth factor receptor-2: combined ligand and target-based approach. Journal of Medicinal Chemistry. 51: 3367-77. PMID 18500794 DOI: 10.1021/jm7013875  0.72
2008 Garofalo A, Grande F, Brizzi A, Aiello F, Dayam R, Neamati N. Naphthoxazepine inhibitors of HIV-1 integrase: synthesis and biological evaluation. Chemmedchem. 3: 986-90. PMID 18383063 DOI: 10.1002/cmdc.200800026  0.76
2008 Al-Mawsawi LQ, Christ F, Dayam R, Debyser Z, Neamati N. Inhibitory profile of a LEDGF/p75 peptide against HIV-1 integrase: Insight into integrase-DNA complex formation and catalysis Febs Letters. 582: 1425-1430. PMID 18331842 DOI: 10.1016/j.febslet.2008.02.076  1
2008 Grande F, Garofalo A, Neamati N. Small molecules anti-HIV therapeutics targeting CXCR4. Current Pharmaceutical Design. 14: 385-404. PMID 18289065  0.76
2008 Dayam R, Al-Mawsawi LQ, Zawahir Z, Witvrouw M, Debyser Z, Neamati N. Quinolone 3-carboxylic acid pharmacophore: Design of second generation HIV-1 integrase inhibitors Journal of Medicinal Chemistry. 51: 1136-1144. PMID 18281931 DOI: 10.1021/jm070609b  1
2008 Dayam R, Gundla R, Al-Mawsawi LQ, Neamati N. HIV-1 integrase inhibitors: 2005-2006 update. Medicinal Research Reviews. 28: 118-54. PMID 17979144 DOI: 10.1002/med.20116  1
2007 Al-Mawsawi LQ, Dayam R, Taheri L, Witvrouw M, Debyser Z, Neamati N. Discovery of novel non-cytotoxic salicylhydrazide containing HIV-1 integrase inhibitors Bioorganic and Medicinal Chemistry Letters. 17: 6472-6475. PMID 17950601 DOI: 10.1016/j.bmcl.2007.09.102  1
2007 Dayam R, Al-Mawsawi LQ, Neamati N. Substituted 2-pyrrolinone inhibitors of HIV-1 integrase. Bioorganic & Medicinal Chemistry Letters. 17: 6155-9. PMID 17911021 DOI: 10.1016/j.bmcl.2007.09.061  1
2007 Al-Mawsawi LQ, Neamati N. Blocking interactions between HIV-1 integrase and cellular cofactors: an emerging anti-retroviral strategy. Trends in Pharmacological Sciences. 28: 526-35. PMID 17888520 DOI: 10.1016/j.tips.2007.09.005  1
2007 Deng J, Sanchez T, Al-Mawsawi LQ, Dayam R, Yunes RA, Garofalo A, Bolger MB, Neamati N. Discovery of structurally diverse HIV-1 integrase inhibitors based on a chalcone pharmacophore. Bioorganic & Medicinal Chemistry. 15: 4985-5002. PMID 17502148 DOI: 10.1016/j.bmc.2007.04.041  1
2007 Dayam R, Al-Mawsawi LQ, Neamati N. HIV-1 integrase inhibitors: an emerging clinical reality. Drugs in R&D. 8: 155-68. PMID 17472411 DOI: 10.2165/00126839-200708030-00003  1
2007 Al-Mawsawi LQ, Sechi M, Neamati N. Single amino acid substitution in HIV-1 integrase catalytic core causes a dramatic shift in inhibitor selectivity. Febs Letters. 581: 1151-6. PMID 17328897 DOI: 10.1016/j.febslet.2007.02.023  1
2007 Deng J, Grande F, Neamati N. Small molecule inhibitors of Stat3 signaling pathway. Current Cancer Drug Targets. 7: 91-107. PMID 17305481  0.76
2007 Deng J, Dayam R, Al-Mawsawi LQ, Neamati N. Design of second generation HIV-1 integrase inhibitors. Current Pharmaceutical Design. 13: 129-41. PMID 17269923 DOI: 10.2174/138161207779313687  1
2007 Patil S, Kamath S, Sanchez T, Neamati N, Schinazi RF, Buolamwini JK. Synthesis and biological evaluation of novel 5(H)-phenanthridin-6-ones, 5(H)-phenanthridin-6-one diketo acid, and polycyclic aromatic diketo acid analogs as new HIV-1 integrase inhibitors. Bioorganic & Medicinal Chemistry. 15: 1212-28. PMID 17158051 DOI: 10.1016/j.bmc.2006.11.026  1
2007 Grande F, Aiello F, Grazia OD, Brizzi A, Garofalo A, Neamati N. Synthesis and antitumor activities of a series of novel quinoxalinhydrazides. Bioorganic & Medicinal Chemistry. 15: 288-94. PMID 17085054 DOI: 10.1016/j.bmc.2006.09.073  0.76
2007 Meadows DC, Sanchez T, Neamati N, North TW, Gervay-Hague J. Ring substituent effects on biological activity of vinyl sulfones as inhibitors of HIV-1. Bioorganic & Medicinal Chemistry. 15: 1127-37. PMID 17074494 DOI: 10.1016/j.bmc.2006.10.017  1
2006 Deng J, Dayam R, Neamati N. Patented small molecule inhibitors of p53-MDM2 interaction. Expert Opinion On Therapeutic Patents. 16: 165-88. PMID 20141510 DOI: 10.1517/13543776.16.2.165  0.72
2006 Robinette D, Neamati N, Tomer KB, Borchers CH. Photoaffinity labeling combined with mass spectrometric approaches as a tool for structural proteomics. Expert Review of Proteomics. 3: 399-408. PMID 16901199 DOI: 10.1586/14789450.3.4.399  1
2006 Dayam R, Sanchez T, Neamati N. Discovery and structure-activity relationship studies of a unique class of HIV-1 integrase inhibitors. Chemmedchem. 1: 238-44. PMID 16892356 DOI: 10.1002/cmdc.200500018  0.72
2006 Zawahir Z, Neamati N. Inhibition of HIV-1 integrase activity by synthetic peptides derived from the HIV-1 HXB2 Pol region of the viral genome. Bioorganic & Medicinal Chemistry Letters. 16: 5199-202. PMID 16879966 DOI: 10.1016/j.bmcl.2006.07.022  1
2006 Dayam R, Aiello F, Deng J, Wu Y, Garofalo A, Chen X, Neamati N. Discovery of small molecule integrin alphavbeta3 antagonists as novel anticancer agents. Journal of Medicinal Chemistry. 49: 4526-34. PMID 16854058 DOI: 10.1021/jm051296s  0.72
2006 Li HY, Zawahir Z, Song LD, Long YQ, Neamati N. Sequence-based design and discovery of peptide inhibitors of HIV-1 integrase: insight into the binding mode of the enzyme. Journal of Medicinal Chemistry. 49: 4477-86. PMID 16854053 DOI: 10.1021/jm060307u  1
2006 Sechi M, Bacchi A, Carcelli M, Compari C, Duce E, Fisicaro E, Rogolino D, Gates P, Derudas M, Al-Mawsawi LQ, Neamati N. From ligand to complexes: inhibition of human immunodeficiency virus type 1 integrase by beta-diketo acid metal complexes. Journal of Medicinal Chemistry. 49: 4248-60. PMID 16821784 DOI: 10.1021/jm060193m  1
2006 Al-Mawsawi LQ, Fikkert V, Dayam R, Witvrouw M, Burke TR, Borchers CH, Neamati N. Discovery of a small-molecule HIV-1 integrase inhibitor-binding site. Proceedings of the National Academy of Sciences of the United States of America. 103: 10080-5. PMID 16785440 DOI: 10.1073/pnas.0511254103  1
2006 Deng J, Sanchez T, Neamati N, Briggs JM. Dynamic pharmacophore model optimization: identification of novel HIV-1 integrase inhibitors. Journal of Medicinal Chemistry. 49: 1684-92. PMID 16509584 DOI: 10.1021/jm0510629  1
2006 Dayam R, Deng J, Neamati N. HIV-1 integrase inhibitors: 2003-2004 update. Medicinal Research Reviews. 26: 271-309. PMID 16496343 DOI: 10.1002/med.20054  0.72
2006 Deng J, Kelley JA, Barchi JJ, Sanchez T, Dayam R, Pommier Y, Neamati N. Mining the NCI antiviral compounds for HIV-1 integrase inhibitors Bioorganic and Medicinal Chemistry. 14: 3785-3792. PMID 16460953 DOI: 10.1016/j.bmc.2006.01.040  1
2005 Dayam R, Sanchez T, Neamati N. Diketo acid pharmacophore. 2. Discovery of structurally diverse inhibitors of HIV-1 integrase. Journal of Medicinal Chemistry. 48: 8009-15. PMID 16335925 DOI: 10.1021/jm050837a  0.72
2005 Plasencia C, Dayam R, Wang Q, Pinski J, Burke TR, Quinn DI, Neamati N. Discovery and preclinical evaluation of a novel class of small-molecule compounds in hormone-dependent and -independent cancer cell lines. Molecular Cancer Therapeutics. 4: 1105-13. PMID 16020668 DOI: 10.1158/1535-7163.MCT-04-0288  0.72
2005 Meadows DC, Mathews TB, North TW, Hadd MJ, Kuo CL, Neamati N, Gervay-Hague J. Synthesis and biological evaluation of geminal disulfones as HIV-1 integrase inhibitors. Journal of Medicinal Chemistry. 48: 4526-34. PMID 15999991 DOI: 10.1021/jm049171v  1
2005 Deng J, Lee KW, Sanchez T, Cui M, Neamati N, Briggs JM. Dynamic receptor-based pharmacophore model development and its application in designing novel HIV-1 integrase inhibitors. Journal of Medicinal Chemistry. 48: 1496-505. PMID 15743192 DOI: 10.1021/jm049410e  1
2005 Sechi M, Sannia L, Carta F, Palomba M, Dallocchio R, Dessì A, Derudas M, Zawahir Z, Neamati N. Design of novel bioisosteres of beta-diketo acid inhibitors of HIV-1 integrase. Antiviral Chemistry & Chemotherapy. 16: 41-61. PMID 15739621  1
2005 Dayam R, Sanchez T, Clement O, Shoemaker R, Sei S, Neamati N. Beta-diketo acid pharmacophore hypothesis. 1. Discovery of a novel class of HIV-1 integrase inhibitors. Journal of Medicinal Chemistry. 48: 111-20. PMID 15634005 DOI: 10.1021/jm0496077  0.72
2004 Dayam R, Neamati N. Active site binding modes of the beta-diketoacids: a multi-active site approach in HIV-1 integrase inhibitor design. Bioorganic & Medicinal Chemistry. 12: 6371-81. PMID 15556755 DOI: 10.1016/j.bmc.2004.09.035  0.72
2004 Sechi M, Derudas M, Dallocchio R, Dessì A, Bacchi A, Sannia L, Carta F, Palomba M, Ragab O, Chan C, Shoemaker R, Sei S, Dayam R, Neamati N. Design and synthesis of novel indole beta-diketo acid derivatives as HIV-1 integrase inhibitors. Journal of Medicinal Chemistry. 47: 5298-310. PMID 15456274 DOI: 10.1021/jm049944f  0.72
2004 Chi G, Neamati N, Nair V. Inhibition of the strand transfer step of HIV-1 integrase by non-natural dinucleotides. Bioorganic & Medicinal Chemistry Letters. 14: 4815-7. PMID 15341930 DOI: 10.1016/j.bmcl.2004.07.050  1
2004 Aiello F, Brizzi A, Garofalo A, Grande F, Ragno G, Dayam R, Neamati N. Synthesis of novel thiazolothiazepine based HIV-1 integrase inhibitors. Bioorganic & Medicinal Chemistry. 12: 4459-66. PMID 15265496 DOI: 10.1016/j.bmc.2004.05.037  0.76
2004 Sechi M, Angotzi G, Dallocchio R, Dessì A, Carta F, Sannia L, Mariani A, Fiori S, Sanchez T, Movsessian L, Plasencia C, Neamati N. Design and synthesis of novel dihydroxyindole-2-carboxylic acids as HIV-1 integrase inhibitors. Antiviral Chemistry & Chemotherapy. 15: 67-81. PMID 15185725  0.52
2004 Long YQ, Jiang XH, Dayam R, Sanchez T, Shoemaker R, Sei S, Neamati N. Rational design and synthesis of novel dimeric diketoacid-containing inhibitors of HIV-1 integrase: implication for binding to two metal ions on the active site of integrase. Journal of Medicinal Chemistry. 47: 2561-73. PMID 15115398 DOI: 10.1021/jm030559k  0.72
2004 Nakayama K, Kanzaki A, Terada K, Mutoh M, Ogawa K, Sugiyama T, Takenoshita S, Itoh K, Yaegashi N, Miyazaki K, Neamati N, Takebayashi Y. Prognostic value of the Cu-transporting ATPase in ovarian carcinoma patients receiving cisplatin-based chemotherapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 2804-11. PMID 15102688 DOI: 10.1158/1078-0432.CCR-03-0454  1
2004 Kuo CL, Assefa H, Kamath S, Brzozowski Z, Slawinski J, Saczewski F, Buolamwini JK, Neamati N. Application of CoMFA and CoMSIA 3D-QSAR and docking studies in optimization of mercaptobenzenesulfonamides as HIV-1 integrase inhibitors. Journal of Medicinal Chemistry. 47: 385-99. PMID 14711310 DOI: 10.1021/jm030378i  1
2003 Dayam R, Neamati N. Small-molecule HIV-1 integrase inhibitors: the 2001-2002 update. Current Pharmaceutical Design. 9: 1789-802. PMID 12871197  0.72
2002 Neamati N, Lin Z, Karki RG, Orr A, Cowansage K, Strumberg D, Pais GC, Voigt JH, Nicklaus MC, Winslow HE, Zhao H, Turpin JA, Yi J, Skalka AM, Burke TR, et al. Metal-dependent inhibition of HIV-1 integrase. Journal of Medicinal Chemistry. 45: 5661-70. PMID 12477350 DOI: 10.1021/jm0201417  1
2002 Pluymers W, Pais G, Van Maele B, Pannecouque C, Fikkert V, Burke TR, De Clercq E, Witvrouw M, Neamati N, Debyser Z. Inhibition of human immunodeficiency virus type 1 integration by diketo derivatives. Antimicrobial Agents and Chemotherapy. 46: 3292-7. PMID 12234864  0.52
2002 Nakayama K, Kanzaki A, Ogawa K, Miyazaki K, Neamati N, Takebayashi Y. Copper-transporting P-type adenosine triphosphatase (ATP7B) as a cisplatin based chemoresistance marker in ovarian carcinoma: comparative analysis with expression of MDR1, MRP1, MRP2, LRP and BCRP. International Journal of Cancer. 101: 488-95. PMID 12216079 DOI: 10.1002/ijc.10608  1
2002 Pais GC, Zhang X, Marchand C, Neamati N, Cowansage K, Svarovskaia ES, Pathak VK, Tang Y, Nicklaus M, Pommier Y, Burke TR. Structure activity of 3-aryl-1,3-diketo-containing compounds as HIV-1 integrase inhibitors. Journal of Medicinal Chemistry. 45: 3184-94. PMID 12109903 DOI: 10.1021/jm020037p  1
2002 Neamati N, Barchi JJ. New paradigms in drug design and discovery. Current Topics in Medicinal Chemistry. 2: 211-227. PMID 11944817  1
2002 Marchand C, Zhang X, Pais GC, Cowansage K, Neamati N, Burke TR, Pommier Y. Structural determinants for HIV-1 integrase inhibition by beta-diketo acids. The Journal of Biological Chemistry. 277: 12596-603. PMID 11805103 DOI: 10.1074/jbc.M110758200  1
2002 Kanzaki A, Toi M, Neamati N, Miyashita H, Oubu M, Nakayama K, Bando H, Ogawa K, Mutoh M, Mori S, Terada K, Sugiyama T, Fukumoto M, Takebayashi Y. Copper-transporting P-type adenosine triphosphatase (ATP7B) is expressed in human breast carcinoma. Japanese Journal of Cancer Research : Gann. 93: 70-7. PMID 11802810  1
2002 Melek M, Jones JM, O'Dea MH, Pais G, Burke TR, Pommier Y, Neamati N, Gellert M. Effect of HIV integrase inhibitors on the RAG1/2 recombinase. Proceedings of the National Academy of Sciences of the United States of America. 99: 134-7. PMID 11756686 DOI: 10.1073/pnas.012610699  0.44
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