Robert L. Geahlen - Publications

Medicinal Chemistry and Molecular Pharmacology Purdue University, West Lafayette, IN, United States 
Molecular Biology, Biochemistry

124 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Wang WH, Krisenko MO, Higgins RL, Morman RE, Geahlen RL. A Mouse Model for the Study of SYK Function through Chemical Genetics Demonstrates SYK-Dependent Signaling through the B Cell Receptor, but Not TLR4. Immunohorizons. 3: 254-261. PMID 31356155 DOI: 10.4049/immunohorizons.1800084  0.356
2019 Arrington J, Xue L, Wang WH, Geahlen RL, Tao WA. Identification of the Direct Substrates of the ABL Kinase via Kinase Assay Linked Phosphoproteomics with Multiple Drug Treatments. Journal of Proteome Research. PMID 30869898 DOI: 10.1021/Acs.Jproteome.8B00942  0.682
2019 Shinde A, Hardy SD, Kim D, Akhand SS, Jolly MK, Wang WH, Anderson JC, Khodadadi RB, Brown WS, George JT, Liu S, Wan J, Levine H, Willey CD, Krusemark CJ, ... Geahlen RL, et al. Spleen tyrosine kinase-mediated autophagy is required for epithelial-mesenchymal plasticity and metastasis in breast cancer. Cancer Research. PMID 30733195 DOI: 10.1158/0008-5472.Can-18-2636  0.398
2017 Westbroek ML, Geahlen RL. Modulation of BCR Signaling by the Induced Dimerization of Receptor-Associated SYK. Antibodies (Basel, Switzerland). 6. PMID 31548538 DOI: 10.3390/Antib6040023  0.438
2017 Zeng L, Wang WH, Arrington J, Shao G, Geahlen RL, Hu CD, Tao WA. Identification of Upstream Kinases by Fluorescence Complementation Mass Spectrometry. Acs Central Science. 3: 1078-1085. PMID 29104924 DOI: 10.1021/Acscentsci.7B00261  0.702
2015 McGee RL, Krisenko MO, Geahlen RL, Rundell AE, Buzzard GT. A Computational Study of the Effects of Syk Activity on B Cell Receptor Signaling Dynamics. Processes (Basel, Switzerland). 3: 75-97. PMID 26525178 DOI: 10.3390/pr3010075  0.333
2015 Krisenko MO, Higgins RL, Ghosh S, Zhou Q, Trybula JS, Wang WH, Geahlen RL. Syk is Recruited to Stress Granules and Promotes their Clearance through Autophagy. The Journal of Biological Chemistry. PMID 26429917 DOI: 10.1074/Jbc.M115.642900  0.336
2015 Cartagena-Rivera AX, Wang WH, Geahlen RL, Raman A. Fast, multi-frequency, and quantitative nanomechanical mapping of live cells using the atomic force microscope. Scientific Reports. 5: 11692. PMID 26118423 DOI: 10.1038/Srep11692  0.337
2015 Iliuk A, Jayasundera K, Wang WH, Schluttenhofer R, Geahlen RL, Tao WA. In-Depth Analyses of B Cell Signaling Through Tandem Mass Spectrometry of Phosphopeptides Enriched by PolyMAC. International Journal of Mass Spectrometry. 377: 744-753. PMID 25954137 DOI: 10.1016/J.Ijms.2014.08.032  0.563
2015 Krisenko MO, Cartagena A, Raman A, Geahlen RL. Nanomechanical property maps of breast cancer cells as determined by multiharmonic atomic force microscopy reveal Syk-dependent changes in microtubule stability mediated by MAP1B. Biochemistry. 54: 60-8. PMID 24914616 DOI: 10.1021/Bi500325N  0.41
2014 Wang WH, Childress MO, Geahlen RL. Syk interacts with and phosphorylates nucleolin to stabilize Bcl-x(L) mRNA and promote cell survival. Molecular and Cellular Biology. 34: 3788-99. PMID 25092868 DOI: 10.1128/Mcb.00937-14  0.313
2014 Geahlen RL. Getting Syk: spleen tyrosine kinase as a therapeutic target. Trends in Pharmacological Sciences. 35: 414-22. PMID 24975478 DOI: 10.1016/  0.358
2014 Jayasundera KB, Iliuk AB, Nguyen A, Higgins R, Geahlen RL, Tao WA. Global phosphoproteomics of activated B cells using complementary metal ion functionalized soluble nanopolymers. Analytical Chemistry. 86: 6363-71. PMID 24905233 DOI: 10.1021/Ac500599R  0.676
2013 Chen CH, Piraner D, Gorenstein NM, Geahlen RL, Beth Post C. Differential recognition of syk-binding sites by each of the two phosphotyrosine-binding pockets of the Vav SH2 domain. Biopolymers. 99: 897-907. PMID 23955592 DOI: 10.1002/Bip.22371  0.517
2013 Huang R, Oh H, Arrendale A, Martin VA, Galan J, Workman EJ, Stout JR, Walczak CE, Tao WA, Borch RF, Geahlen RL. Intracellular targets for a phosphotyrosine peptidomimetic include the mitotic kinesin, MCAK. Biochemical Pharmacology. 86: 597-611. PMID 23830822 DOI: 10.1016/J.Bcp.2013.06.024  0.775
2013 Xue L, Geahlen RL, Tao WA. Identification of direct tyrosine kinase substrates based on protein kinase assay-linked phosphoproteomics. Molecular & Cellular Proteomics : McP. 12: 2969-80. PMID 23793017 DOI: 10.1074/Mcp.O113.027722  0.704
2013 Fei B, Yu S, Geahlen RL. Modulation by Syk of Bcl-2, calcium and the calpain-calpastatin proteolytic system in human breast cancer cells. Biochimica Et Biophysica Acta. 1833: 2153-64. PMID 23684705 DOI: 10.1016/J.Bbamcr.2013.05.010  0.588
2013 Hu L, Yang L, Lipchik AM, Geahlen RL, Parker LL, Tao WA. A quantitative proteomics-based competition binding assay to characterize pITAM-protein interactions. Analytical Chemistry. 85: 5071-7. PMID 23611696 DOI: 10.1021/Ac400359T  0.605
2013 Yu S, Huang H, Iliuk A, Wang WH, Jayasundera KB, Tao WA, Post CB, Geahlen RL. Syk inhibits the activity of protein kinase A by phosphorylating tyrosine 330 of the catalytic subunit. The Journal of Biological Chemistry. 288: 10870-81. PMID 23447535 DOI: 10.1074/Jbc.M112.426130  0.745
2013 Yu S, Huang H, Iliuk A, Wang W, Tao WA, Post CB, Geahlen RL. Abstract 542: Syk inhibits the activity of protein kinase A by phosphorylating tyrosine 330 of the catalytic subunit in breast cancer cells. Cancer Research. 73: 542-542. DOI: 10.1158/1538-7445.Am2013-542  0.665
2012 Pan L, Iliuk A, Yu S, Geahlen RL, Tao WA. Multiplexed quantitation of protein expression and phosphorylation based on functionalized soluble nanopolymers. Journal of the American Chemical Society. 134: 18201-4. PMID 23088311 DOI: 10.1021/Ja308453M  0.72
2012 Lipchik AM, Killins RL, Geahlen RL, Parker LL. A peptide-based biosensor assay to detect intracellular Syk kinase activation and inhibition. Biochemistry. 51: 7515-24. PMID 22920457 DOI: 10.1021/Bi300970H  0.521
2012 Arrendale A, Kim K, Choi JY, Li W, Geahlen RL, Borch RF. Synthesis of a phosphoserine mimetic prodrug with potent 14-3-3 protein inhibitory activity. Chemistry & Biology. 19: 764-71. PMID 22726690 DOI: 10.1016/J.Chembiol.2012.05.011  0.522
2012 Xue L, Wang WH, Iliuk A, Hu L, Galan JA, Yu S, Hans M, Geahlen RL, Tao WA. Sensitive kinase assay linked with phosphoproteomics for identifying direct kinase substrates. Proceedings of the National Academy of Sciences of the United States of America. 109: 5615-20. PMID 22451900 DOI: 10.1073/Pnas.1119418109  0.824
2012 Martin VA, Wang WH, Lipchik AM, Parker LL, He Y, Zhang S, Zhang ZY, Geahlen RL. Akt2 inhibits the activation of NFAT in lymphocytes by modulating calcium release from intracellular stores. Cellular Signalling. 24: 1064-73. PMID 22261254 DOI: 10.1016/J.Cellsig.2012.01.001  0.39
2012 Moon KD, Zhang X, Zhou Q, Geahlen RL. The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2. Biochimica Et Biophysica Acta. 1823: 199-205. PMID 22019427 DOI: 10.1016/J.Bbamcr.2011.10.001  0.73
2011 Chen CH, Martin VA, Gorenstein NM, Geahlen RL, Post CB. Two closely spaced tyrosines regulate NFAT signaling in B cells via Syk association with Vav. Molecular and Cellular Biology. 31: 2984-96. PMID 21606197 DOI: 10.1128/Mcb.05043-11  0.5
2011 Galan JA, Paris LL, Zhang HJ, Adler J, Geahlen RL, Tao WA. Proteomic studies of Syk-interacting proteins using a novel amine-specific isotope tag and GFP nanotrap. Journal of the American Society For Mass Spectrometry. 22: 319-28. PMID 21472591 DOI: 10.1007/S13361-010-0030-7  0.772
2011 Chen C, Piraner D, Gorenstein N, Geahlen R, Post C. Solution structure of the Vav1 SH2 domain complexed with a Syk-derived singly phosphorylated peptide Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Lct/Pdb  0.353
2011 Arrendale AA, Huang R, Geahlen R, Borch R. Abstract B184: Design, synthesis, and evaluation of novel mitotic centromere-associated kinesin (MCAK) inhibitors. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-B184  0.396
2011 Arrendale AA, Kim K, Geahlen R, Borch RF. Abstract A124: Synthesis of a phosphoserine mimetic prodrug with potent 14-3-3 protein inhibitory activity. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-A124  0.447
2010 Paris LL, Hu J, Galan J, Ong SS, Martin VA, Ma H, Tao WA, Harrison ML, Geahlen RL. Regulation of Syk by phosphorylation on serine in the linker insert. The Journal of Biological Chemistry. 285: 39844-54. PMID 20956537 DOI: 10.1074/Jbc.M110.164509  0.798
2010 Wang J, Fei B, Geahlen RL, Lu C. Quantitative analysis of protein translocations by microfluidic total internal reflection fluorescence flow cytometry. Lab On a Chip. 10: 2673-9. PMID 20820633 DOI: 10.1039/C0Lc00131G  0.431
2010 Iliuk AB, Martin VA, Alicie BM, Geahlen RL, Tao WA. In-depth analyses of kinase-dependent tyrosine phosphoproteomes based on metal ion-functionalized soluble nanopolymers. Molecular & Cellular Proteomics : McP. 9: 2162-72. PMID 20562096 DOI: 10.1074/Mcp.M110.000091  0.626
2010 Zhan Y, Martin VA, Geahlen RL, Lu C. One-step extraction of subcellular proteins from eukaryotic cells. Lab On a Chip. 10: 2046-8. PMID 20548993 DOI: 10.1039/C005152G  0.415
2010 HE H, GEAHLEN RL, CUSHMAN M. ChemInform Abstract: Synthesis of a Series of Brominated 1-Phenyl-2-pyridylethenes as Inhibitors of the Protein-Tyrosine Kinase p56lck. Cheminform. 26: no-no. DOI: 10.1002/chin.199505167  0.422
2010 CUSHMAN M, NAGARATHNAM D, BURG DL, GEAHLEN RL. ChemInform Abstract: Synthesis and Protein-Tyrosine Kinase Inhibitory Activities of Flavonoid Analogues. Cheminform. 22: no-no. DOI: 10.1002/chin.199139159  0.455
2009 Zhang X, Shrikhande U, Alicie BM, Zhou Q, Geahlen RL. Role of the protein tyrosine kinase Syk in regulating cell-cell adhesion and motility in breast cancer cells. Molecular Cancer Research : McR. 7: 634-44. PMID 19435818 DOI: 10.1158/1541-7786.Mcr-08-0371  0.564
2009 Geahlen RL. Syk and pTyr'd: Signaling through the B cell antigen receptor. Biochimica Et Biophysica Acta. 1793: 1115-27. PMID 19306898 DOI: 10.1016/J.Bbamcr.2009.03.004  0.536
2009 Zhou Q, Geahlen RL. The protein-tyrosine kinase Syk interacts with TRAF-interacting protein TRIP in breast epithelial cells Oncogene. 28: 1348-1356. PMID 19151749 DOI: 10.1038/Onc.2008.493  0.513
2008 Wang J, Bao N, Paris LL, Geahlen RL, Lu C. Total internal reflection fluorescence flow cytometry. Analytical Chemistry. 80: 9840-4. PMID 19007249 DOI: 10.1021/Ac801940W  0.717
2008 Zhang Y, Oh H, Burton RA, Burgner JW, Geahlen RL, Post CB. Tyr130 phosphorylation triggers Syk release from antigen receptor by long-distance conformational uncoupling. Proceedings of the National Academy of Sciences of the United States of America. 105: 11760-5. PMID 18689684 DOI: 10.1073/Pnas.0708583105  0.679
2008 Wang J, Bao N, Paris LL, Wang HY, Geahlen RL, Lu C. Detection of kinase translocation using microfluidic electroporative flow cytometry. Analytical Chemistry. 80: 1087-93. PMID 18154306 DOI: 10.1021/Ac702065E  0.786
2008 Lebouvier T, Scales TM, Hanger DP, Geahlen RL, Lardeux B, Reynolds CH, Anderton BH, Derkinderen P. The microtubule-associated protein tau is phosphorylated by Syk. Biochimica Et Biophysica Acta. 1783: 188-92. PMID 18070606 DOI: 10.1016/J.Bbamcr.2007.11.005  0.511
2008 Li M, Ong SS, Rajwa B, Thieu VT, Geahlen RL, Harrison ML. The SH3 domain of Lck modulates T-cell receptor-dependent activation of extracellular signal-regulated kinase through activation of Raf-1. Molecular and Cellular Biology. 28: 630-41. PMID 17998336 DOI: 10.1128/Mcb.00150-07  0.467
2007 Oh H, Ozkirimli E, Shah K, Harrison ML, Geahlen RL. Generation of an analog-sensitive Syk tyrosine kinase for the study of signaling dynamics from the B cell antigen receptor. The Journal of Biological Chemistry. 282: 33760-8. PMID 17913708 DOI: 10.1074/Jbc.M704846200  0.705
2007 Zhou F, Galan J, Geahlen RL, Tao WA. A novel quantitative proteomics strategy to study phosphorylation-dependent peptide-protein interactions. Journal of Proteome Research. 6: 133-40. PMID 17203957 DOI: 10.1021/Pr0602904  0.812
2006 Garrido-Hernandez H, Moon KD, Geahlen RL, Borch RF. Design and synthesis of phosphotyrosine peptidomimetic prodrugs. Journal of Medicinal Chemistry. 49: 3368-76. PMID 16722656 DOI: 10.1021/Jm060142P  0.586
2006 Zhou F, Hu J, Ma H, Harrison ML, Geahlen RL. Nucleocytoplasmic trafficking of the Syk protein tyrosine kinase. Molecular and Cellular Biology. 26: 3478-91. PMID 16611990 DOI: 10.1128/Mcb.26.9.3478-3491.2006  0.723
2006 Groesch TD, Zhou F, Mattila S, Geahlen RL, Post CB. Structural basis for the requirement of two phosphotyrosine residues in signaling mediated by Syk tyrosine kinase. Journal of Molecular Biology. 356: 1222-36. PMID 16410013 DOI: 10.1016/J.Jmb.2005.11.095  0.559
2005 Morefield GL, Jiang D, Romero-Mendez IZ, Geahlen RL, Hogenesch H, Hem SL. Effect of phosphorylation of ovalbumin on adsorption by aluminum-containing adjuvants and elution upon exposure to interstitial fluid. Vaccine. 23: 1502-6. PMID 15670886 DOI: 10.1016/J.Vaccine.2004.08.048  0.336
2005 Simon M, Vanes L, Geahlen RL, Tybulewicz VL. Distinct roles for the linker region tyrosines of Syk in FcepsilonRI signaling in primary mast cells. The Journal of Biological Chemistry. 280: 4510-7. PMID 15576379 DOI: 10.1074/Jbc.M410326200  0.517
2005 Moon KD, Post CB, Durden DL, Zhou Q, De P, Harrison ML, Geahlen RL. Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase. The Journal of Biological Chemistry. 280: 1543-51. PMID 15536084 DOI: 10.1074/Jbc.M407805200  0.69
2005 Zheng Y, Balakrishnan V, Buzzard G, Geahlen R, Harrison M, Rundell A. Modeling and analysis of early events in T-lymphocyte antigen-activated intracellular-signaling pathways Journal of Computational and Applied Mathematics. 184: 320-341. DOI: 10.1016/J.Cam.2004.08.015  0.358
2004 Moore LL, Fulton AM, Harrison ML, Geahlen RL. Anti-sulfonylbenzoate antibodies as a tool for the detection of nucleotide-binding proteins for functional proteomics. Journal of Proteome Research. 3: 1184-90. PMID 15595727 DOI: 10.1021/Pr0498943  0.436
2004 Geahlen RL, Handley MD, Harrison ML. Molecular interdiction of Src-family kinase signaling in hematopoietic cells. Oncogene. 23: 8024-32. PMID 15489920 DOI: 10.1038/Sj.Onc.1208078  0.582
2004 Zolodz MD, Wood KV, Regnier FE, Geahlen RL. New approach for analysis of the phosphotyrosine proteome and its application to the chicken B cell line, DT40. Journal of Proteome Research. 3: 743-50. PMID 15359727 DOI: 10.1021/Pr049967I  0.54
2002 Hong JJ, Yankee TM, Harrison ML, Geahlen RL. Regulation of signaling in B cells through the phosphorylation of Syk on linker region tyrosines. A mechanism for negative signaling by the Lyn tyrosine kinase. The Journal of Biological Chemistry. 277: 31703-14. PMID 12077122 DOI: 10.1074/Jbc.M201362200  0.673
2002 Hawash IY, Hu XE, Adal A, Cassady JM, Geahlen RL, Harrison ML. The oxygen-substituted palmitic acid analogue, 13-oxypalmitic acid, inhibits Lck localization to lipid rafts and T cell signaling. Biochimica Et Biophysica Acta. 1589: 140-50. PMID 12007789 DOI: 10.1016/S0167-4889(02)00165-9  0.375
2002 Kesavan KP, Isaacson CC, Ashendel CL, Geahlen RL, Harrison ML. Characterization of the in vivo sites of serine phosphorylation on Lck identifying serine 59 as a site of mitotic phosphorylation. The Journal of Biological Chemistry. 277: 14666-73. PMID 11847223 DOI: 10.1074/Jbc.M111911200  0.581
2002 Kim JS, Peng X, De PK, Geahlen RL, Durden DL. PTEN controls immunoreceptor (immunoreceptor tyrosine-based activation motif) signaling and the activation of Rac. Blood. 99: 694-7. PMID 11781256 DOI: 10.1182/Blood.V99.2.694  0.535
2002 Hawash IY, Kesavan KP, Magee AI, Geahlen RL, Harrison ML. The Lck SH3 domain negatively regulates localization to lipid rafts through an interaction with c-Cbl. The Journal of Biological Chemistry. 277: 5683-91. PMID 11741956 DOI: 10.1074/Jbc.M110002200  0.353
2001 Zhou YJ, Chen M, Cusack NA, Kimmel LH, Magnuson KS, Boyd JG, Lin W, Roberts JL, Lengi A, Buckley RH, Geahlen RL, Candotti F, Gadina M, Changelian PS, O'Shea JJ. Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases. Molecular Cell. 8: 959-69. PMID 11741532 DOI: 10.1016/S1097-2765(01)00398-7  0.463
2001 Vines CM, Potter JW, Xu Y, Geahlen RL, Costello PS, Tybulewicz VL, Lowell CA, Chang PW, Gresham HD, Willman CL. Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr. Immunity. 15: 507-19. PMID 11672534 DOI: 10.1016/S1074-7613(01)00221-7  0.477
2001 Mu F, Coffing SL, Riese DJ, Geahlen RL, Verdier-Pinard P, Hamel TE, Johnson J, Cushman M. Design, synthesis, and biological evaluation of a series of lavendustin A analogues that inhibit EGFR and Syk tyrosine kinases, as well as tubulin polymerization. Journal of Medicinal Chemistry. 44: 441-52. PMID 11462983 DOI: 10.1021/Jm000387G  0.498
2001 Ma H, Yankee TM, Hu J, Asai DJ, Harrison ML, Geahlen RL. Visualization of Syk-antigen receptor interactions using green fluorescent protein: differential roles for Syk and Lyn in the regulation of receptor capping and internalization. Journal of Immunology (Baltimore, Md. : 1950). 166: 1507-16. PMID 11160190 DOI: 10.4049/Jimmunol.166.3.1507  0.688
2000 Zhou YJ, Magnuson KS, Cheng TP, Gadina M, Frucht DM, Galon J, Candotti F, Geahlen RL, Changelian PS, O'Shea JJ. Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: Activation of Syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation Molecular and Cellular Biology. 20: 4371-4380. PMID 10825200 DOI: 10.1128/Mcb.20.12.4371-4380.2000  0.39
2000 Gaul BS, Harrison ML, Geahlen RL, Burton RA, Post CB. Substrate recognition by the Lyn protein-tyrosine kinase: NMR structure of the immunoreceptor-tyrosine-based activation motif signaling region of the B cell antigen receptor Journal of Biological Chemistry. 275: 16174-16182. PMID 10748115 DOI: 10.1074/Jbc.M909044199  0.589
1999 Miller LA, Hong JJ, Kinch MS, Harrison ML, Geahlen RL. The engagement of beta1 integrins on promonocytic cells promotes phosphorylation of Syk and formation of a protein complex containing Lyn and beta1 integrin. European Journal of Immunology. 29: 1426-34. PMID 10359096 DOI: 10.1002/(Sici)1521-4141(199905)29:05<1426::Aid-Immu1426>3.0.Co;2-J  0.667
1999 Stupack DG, Li E, Silletti SA, Kehler JA, Geahlen RL, Hahn K, Nemerow GR, Cheresh DA. Matrix valency regulates integrin-mediated lymphoid adhesion via Syk kinase Journal of Cell Biology. 144: 777-787. PMID 10037798 DOI: 10.1083/Jcb.144.4.777  0.48
1999 Fernandez JA, Keshvara LM, Peters JD, Furlong MT, Harrison ML, Geahlen RL. Phosphorylation- and activation-independent association of the tyrosine kinase Syk and the tyrosine kinase substrates Cbl and Vav with tubulin in B-cells. The Journal of Biological Chemistry. 274: 1401-6. PMID 9880513 DOI: 10.1074/Jbc.274.3.1401  0.595
1999 Chang C, Ashendel CL, Chan TCK, Geahlen RL, McLaughlin J, Waters DJ. Oncogene signal transduction inhibitors from Chinese medicinal plants Pure and Applied Chemistry. 71: 1101-1104. DOI: 10.1351/Pac199971061101  0.431
1998 McVicar DW, Taylor LS, Gosselin P, Willette-Brown J, Mikhael AI, Geahlen RL, Nakamura MC, Linnemeyer P, Seaman WE, Anderson SK, Ortaldo JR, Mason LH. DAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinase. The Journal of Biological Chemistry. 273: 32934-42. PMID 9830044 DOI: 10.1074/Jbc.273.49.32934  0.527
1997 Keshvara LM, Isaacson C, Harrison ML, Geahlen RL. Syk activation and dissociation from the B-cell antigen receptor is mediated by phosphorylation of tyrosine 130. The Journal of Biological Chemistry. 272: 10377-81. PMID 9099676 DOI: 10.1074/Jbc.272.16.10377  0.55
1997 Furlong MT, Mahrenholz AM, Kim KH, Ashendel CL, Harrison ML, Geahlen RL. Identification of the major sites of autophosphorylation of the murine protein-tyrosine kinase Syk. Biochimica Et Biophysica Acta. 1355: 177-90. PMID 9042338 DOI: 10.1016/S0167-4889(96)00131-0  0.527
1997 Pathan NI, Ashendel CL, Geahlen RL, Harrison ML. Activation of T cell Raf-1 at mitosis requires the protein-tyrosine kinase Lck. The Journal of Biological Chemistry. 271: 30315-7. PMID 8939988 DOI: 10.1074/Jbc.271.48.30315  0.514
1997 Kim DSHL, Koonchanok NM, Geahlen RL, Ashendel CL, Chang C. Structure Activity Relationship Study of Emodin Derivatives Based on the Protein-Tyrosine Kinase and Protein Kinase C Inhibitory Activities and Cytotoxicity Natural Product Letters. 10: 173-180. DOI: 10.1080/10575639708041191  0.558
1996 Pathan NI, Geahlen RL, Harrison ML. The protein-tyrosine kinase Lck associates with and is phosphorylated by Cdc2. The Journal of Biological Chemistry. 271: 27517-23. PMID 8910336 DOI: 10.1074/Jbc.271.44.27517  0.588
1996 Peters JD, Furlong MT, Asai DJ, Harrison ML, Geahlen RL. Syk, activated by cross-linking the B-cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates alpha-tubulin on tyrosine. The Journal of Biological Chemistry. 271: 4755-62. PMID 8617742 DOI: 10.1074/Jbc.271.9.4755  0.529
1995 Geahlen RL, Burg DL. The role of Syk in cell signaling. Advances in Experimental Medicine and Biology. 365: 103-9. PMID 7887296 DOI: 10.1007/978-1-4899-0987-9_11  0.531
1995 Turner M, Mee PJ, Costello PS, Williams O, Price AA, Duddy LP, Furlong MT, Geahlen RL, Tybulewicz VL. Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature. 378: 298-302. PMID 7477352 DOI: 10.1038/378298A0  0.427
1995 Kim YH, Lee E, Koonchanok NM, Geahlen RL, Ashendel CL, Chang C. Prenylated Flavanones fromDerris laxiflora Natural Product Letters. 6: 223-231. DOI: 10.1080/10575639508043163  0.376
1995 Low PS, Li Q, Kiyatkin A, Rathinavelu P, Geahlen RL, Harrison ML. Signal transduction between red cells and other blood cells Stem Cells. 13: 90-91. DOI: 10.1002/Stem.5530130116  0.313
1994 Corey SJ, Burkhardt AL, Bolen JB, Geahlen RL, Tkatch LS, Tweardy DJ. Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases. Proceedings of the National Academy of Sciences of the United States of America. 91: 4683-7. PMID 8197119 DOI: 10.1073/Pnas.91.11.4683  0.429
1994 Zheng GQ, Hu X, Cassady JM, Paige LA, Geahlen RL. Synthesis of myristoyl CoA analogues and myristoyl peptides as inhibitors of myristoyl CoA:protein N-myristoyltransferase. Journal of Pharmaceutical Sciences. 83: 233-8. PMID 8169796 DOI: 10.1002/Jps.2600830224  0.333
1994 Nadler MJ, Hu XE, Cassady JM, Geahlen RL. Posttranslational acylation of the transferrin receptor in LSTRA cells with myristate, palmitate and stearate: evidence for distinct acyltransferases. Biochimica Et Biophysica Acta. 1213: 100-6. PMID 8011671 DOI: 10.1016/0005-2760(94)90227-5  0.396
1994 Cushman M, Zhu H, Geahlen RL, Kraker AJ. Synthesis and biochemical evaluation of a series of aminoflavones as potential inhibitors of protein-tyrosine kinases p56lck, EGFr, and p60v-src. Journal of Medicinal Chemistry. 37: 3353-62. PMID 7932563 DOI: 10.1021/Jm00046A020  0.347
1994 He H, Geahlen RL, Cushman M. Synthesis of a series of brominated 1-phenyl-2-pyridylethenes as inhibitors of the protein-tyrosine kinase p56lck Bioorganic & Medicinal Chemistry Letters. 4: 1729-1732. DOI: 10.1016/S0960-894X(00)80370-4  0.501
1993 Leprince C, Draves KE, Geahlen RL, Ledbetter JA, Clark EA. CD22 associates with the human surface IgM-B-cell antigen receptor complex Proceedings of the National Academy of Sciences of the United States of America. 90: 3236-3240. PMID 8475064 DOI: 10.1073/Pnas.90.8.3236  0.421
1993 Atherton-Fessler S, Parker LL, Geahlen RL, Piwnica-Worms H. Mechanisms of p34cdc2 regulation. Molecular and Cellular Biology. 13: 1675-85. PMID 8441405 DOI: 10.1128/Mcb.13.3.1675  0.511
1993 Thakkar K, Geahlen RL, Cushman M. Synthesis and protein-tyrosine kinase inhibitory activity of polyhydroxylated stilbene analogues of piceatannol. Journal of Medicinal Chemistry. 36: 2950-5. PMID 8411012 DOI: 10.1021/Jm00072A015  0.464
1993 Abou-Shoer M, Ma GE, Li XH, Koonchanok NM, Geahlen RL, Chang CJ. Flavonoids from Koelreuteria henryi and other sources as protein-tyrosine kinase inhibitors. Journal of Natural Products. 56: 967-9. PMID 8350096 DOI: 10.1021/Np50096A027  0.436
1993 Jayatilake GS, Jayasuriya H, Lee ES, Koonchanok NM, Geahlen RL, Ashendel CL, McLaughlin JL, Chang CJ. Kinase inhibitors from Polygonum cuspidatum. Journal of Natural Products. 56: 1805-10. PMID 8277318 DOI: 10.1021/Np50100A021  0.533
1993 Nadler MJ, Harrison ML, Ashendel CL, Cassady JM, Geahlen RL. Treatment of T cells with 2-hydroxymyristic acid inhibits the myristoylation and alters the stability of p56lck. Biochemistry. 32: 9250-5. PMID 8103677 DOI: 10.1021/Bi00086A034  0.45
1993 Chan TC, Chang CJ, Koonchanok NM, Geahlen RL. Selective inhibition of the growth of ras-transformed human bronchial epithelial cells by emodin, a protein-tyrosine kinase inhibitor. Biochemical and Biophysical Research Communications. 193: 1152-8. PMID 7686746 DOI: 10.1006/Bbrc.1993.1746  0.433
1993 Chang CJ, Geahlen RL. Protein-tyrosine kinase inhibition: mechanism-based discovery of antitumor agents. Journal of Natural Products. 55: 1529-60. PMID 1479375 DOI: 10.1021/Np50089A001  0.517
1993 Schieven GL, Kirihara JM, Geahlen RL, Ledbetter JA. Identification of reactive oxygen intermediate responsive tyrosine kinases in lymphocytes Free Radical Biology and Medicine. 15: 546. DOI: 10.1016/0891-5849(93)90468-A  0.423
1992 Cushman M, Nagarathnam D, Geahlen RL. Synthesis and evaluation of hydroxylated flavones and related compounds as potential inhibitors of the protein-tyrosine kinase p56lck. Journal of Natural Products. 54: 1345-52. PMID 1800636 DOI: 10.1021/Np50077A018  0.431
1992 Geahlen RL, Loudon GM, Paige LA, Lloyd D. A general method for preparation of peptides biotinylated at the carboxy terminus. Analytical Biochemistry. 202: 68-70. PMID 1621986 DOI: 10.1016/0003-2697(92)90207-N  0.302
1992 Jayasuriya H, Koonchanok NM, Geahlen RL, McLaughlin JL, Chang CJ. Emodin, a protein tyrosine kinase inhibitor from Polygonum cuspidatum. Journal of Natural Products. 55: 696-8. PMID 1517743 DOI: 10.1021/Np50083A026  0.506
1992 Hutchcroft JE, Geahlen RL, Deanin GG, Oliver JM. FcεRI-mediated tyrosine phosphorylation and activation of the 72-kDa protein-tyrosine kinase, PTK72, in RBL-2H3 rat tumor mast cells Proceedings of the National Academy of Sciences of the United States of America. 89: 9107-9111. PMID 1409610 DOI: 10.1073/Pnas.89.19.9107  0.599
1991 Anostario M, Harrison ML, Geahlen RL. Immunochemical detection of adenine nucleotide-binding proteins with antibodies to 5'-p-fluorosulfonylbenzoyladenosine. Analytical Biochemistry. 190: 60-5. PMID 2285146 DOI: 10.1016/0003-2697(90)90133-T  0.482
1991 Paige LA, Zheng GQ, DeFrees SA, Cassady JM, Geahlen RL. Metabolic activation of 2-substituted derivatives of myristic acid to form potent inhibitors of myristoyl CoA:protein N-myristoyltransferase. Biochemistry. 29: 10566-73. PMID 2271666 DOI: 10.1021/Bi00498A021  0.344
1991 Cushman M, Chinnasamy P, Chakraborti AK, Jurayj J, Geahlen RL, Haugwitz RD. Synthesis of [beta-(4-pyridyl-1-oxide)-L-alanine4]-angiotensin I as a potential suicide substrate for protein-tyrosine kinases. International Journal of Peptide and Protein Research. 36: 538-43. PMID 2090646 DOI: 10.1111/J.1399-3011.1990.Tb00993.X  0.454
1991 Cushman M, Nagarathnam D, Burg DL, Geahlen RL. Synthesis and protein-tyrosine kinase inhibitory activities of flavonoid analogues. Journal of Medicinal Chemistry. 34: 798-806. PMID 1995903 DOI: 10.1021/Jm00106A047  0.476
1991 Hutchcroft JE, Anostario M, Harrison ML, Geahlen RL. Renaturation and assay of protein kinases after electrophoresis in sodium dodecyl sulfate-polyacrylamide gels. Methods in Enzymology. 200: 417-23. PMID 1956327 DOI: 10.1016/0076-6879(91)00157-R  0.539
1991 Wang QM, Srinivas PR, Harrison ML, Geahlen RL. Partial purification and characterization of the lck protein-tyrosine kinase from bovine thymus. The Biochemical Journal. 567-74. PMID 1953650 DOI: 10.1042/Bj2790567  0.409
1991 Wang Q, Smith JB, Harrison ML, Geahlen RL. Identification of tyrosine 67 in bovine brain myelin basic protein as a specific phosphorylation site for thymus p56lck. Biochemical and Biophysical Research Communications. 178: 1393-9. PMID 1714722 DOI: 10.1016/0006-291X(91)91048-H  0.556
1991 Cushman M, Nagarathnam D, Gopal D, Geahlen RL. Synthesis and evaluation of new protein-tyrosine kinase inhibitors. Part 2. Phenylhydrazones. Bioorganic & Medicinal Chemistry Letters. 1: 215-218. DOI: 10.1016/S0960-894X(00)80255-3  0.538
1991 Cushman M, Nagarathnam D, Gopal D, Geahlen RL. Synthesis and evaluation of new protein-tyrosine kinase inhibitors. Part 1. pyridine-containing stilbenes and amides. Bioorganic & Medicinal Chemistry Letters. 1: 211-214. DOI: 10.1016/S0960-894X(00)80254-1  0.49
1990 Geahlen RL, Koonchanok NM, McLaughlin JL, Pratt DE. Inhibition of protein-tyrosine kinase activity by flavanoids and related compounds. Journal of Natural Products. 52: 982-6. PMID 2607357 DOI: 10.1021/Np50065A011  0.469
1990 Geahlen RL, McLaughlin JL. Piceatannol (3,4,3',5'-tetrahydroxy-trans-stilbene) is a naturally occurring protein-tyrosine kinase inhibitor. Biochemical and Biophysical Research Communications. 165: 241-5. PMID 2590224 DOI: 10.1016/0006-291X(89)91060-7  0.598
1990 Guan KL, Haun RS, Watson SJ, Geahlen RL, Dixon JE. Cloning and expression of a protein-tyrosine-phosphatase. Proceedings of the National Academy of Sciences of the United States of America. 87: 1501-5. PMID 2154749 DOI: 10.1073/Pnas.87.4.1501  0.353
1989 Paige LA, Chafin DR, Cassady JM, Geahlen RL. Detection of myristoyl CoA:protein N-myristoyltransferase activity by ion-exchange chromatography. Analytical Biochemistry. 181: 254-8. PMID 2817389 DOI: 10.1016/0003-2697(89)90239-X  0.374
1989 Paige LA, Zheng GQ, DeFrees SA, Cassady JM, Geahlen RL. S-(2-oxopentadecyl)-CoA, a nonhydrolyzable analogue of myristoyl-CoA, is a potent inhibitor of myristoyl-CoA:protein N-myristoyltransferase. Journal of Medicinal Chemistry. 32: 1665-7. PMID 2754690 DOI: 10.1021/Jm00128A001  0.342
1988 Mahrenholz AM, Votaw P, Roach PJ, Depaoli-Roach AA, Zioncheck TF, Harrison ML, Geahlen RL. Phosphorylation of glycogen synthase by a bovine thymus protein-tyrosine kinase, p40 Biochemical and Biophysical Research Communications. 155: 52-58. PMID 3137939 DOI: 10.1016/S0006-291X(88)81048-9  0.517
1986 Geahlen RL, Harrison ML. Detection of a novel lymphocyte protein-tyrosine kinase by renaturation in polyacrylamide gels. Biochemical and Biophysical Research Communications. 134: 963-9. PMID 3947355 DOI: 10.1016/S0006-291X(86)80514-9  0.584
1986 Geahlen RL, Anostario M, Low PS, Harrison ML. Detection of protein kinase activity in sodium dodecyl sulfate-polyacrylamide gels. Analytical Biochemistry. 153: 151-8. PMID 3457543 DOI: 10.1016/0003-2697(86)90074-6  0.551
1985 Mason DL, Harrison ML, Geahlen RL. Properties of a tyrosine protein kinase from calf thymus. Response to ionic strength and divalent cations. Biochimica Et Biophysica Acta. 829: 221-8. PMID 3873256 DOI: 10.1016/0167-4838(85)90191-8  0.55
1984 Geahlen RL, Harrison ML. Induction of a substrate for casein kinase II during lymphocyte mitogenesis. Biochimica Et Biophysica Acta. 804: 169-75. PMID 6609722 DOI: 10.1016/0167-4889(84)90146-0  0.585
1982 Geahlen RL, Carmichael DF, Hashimoto E, Krebs EG. Phosphorylation of cAMP-dependent protein kinase subunits. Advances in Enzyme Regulation. 20: 195-209. PMID 6287816 DOI: 10.1016/0065-2571(82)90016-4  0.424
1979 Czarnecki J, Geahlen R, Haley B. Synthesis and use of azido photoaffinity analogs of adenine and guanine nucleotides. Methods in Enzymology. 56: 642-53. PMID 459886 DOI: 10.1016/0076-6879(79)56061-3  0.313
1979 Geahlen RL, Haley BE, Krebs EG. Synthesis and use of 8-azidoguanosine 3',5'-cyclic monophosphate as photoaffinity label for cyclic GMP-dependent protein kinase. Proceedings of the National Academy of Sciences of the United States of America. 76: 2213-7. PMID 221918 DOI: 10.1073/Pnas.76.5.2213  0.502
1977 Geahlen RL, Haley BE. Interactions of a photoaffinity analog of GTP with the proteins of microtubules Proceedings of the National Academy of Sciences of the United States of America. 74: 4375-4377. PMID 270679 DOI: 10.1073/Pnas.74.10.4375  0.301
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