Robert L. Geahlen - Publications

Affiliations: 
Medicinal Chemistry and Molecular Pharmacology Purdue University, West Lafayette, IN, United States 
Area:
Molecular Biology, Biochemistry

70 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Wang WH, Krisenko MO, Higgins RL, Morman RE, Geahlen RL. A Mouse Model for the Study of SYK Function through Chemical Genetics Demonstrates SYK-Dependent Signaling through the B Cell Receptor, but Not TLR4. Immunohorizons. 3: 254-261. PMID 31356155 DOI: 10.4049/immunohorizons.1800084  0.44
2019 Arrington J, Xue L, Wang WH, Geahlen RL, Tao WA. Identification of the Direct Substrates of the ABL Kinase via Kinase Assay Linked Phosphoproteomics with Multiple Drug Treatments. Journal of Proteome Research. PMID 30869898 DOI: 10.1021/acs.jproteome.8b00942  0.44
2019 Shinde A, Hardy SD, Kim D, Akhand SS, Jolly MK, Wang WH, Anderson JC, Khodadadi RB, Brown WS, George JT, Liu S, Wan J, Levine H, Willey CD, Krusemark CJ, ... Geahlen RL, et al. Spleen tyrosine kinase-mediated autophagy is required for epithelial-mesenchymal plasticity and metastasis in breast cancer. Cancer Research. PMID 30733195 DOI: 10.1158/0008-5472.CAN-18-2636  0.44
2017 Hardy SD, Shinde A, Wang WH, Wendt MK, Geahlen RL. Regulation of epithelial-mesenchymal transition and metastasis by TGF-β, P-bodies, and autophagy. Oncotarget. 8: 103302-103314. PMID 29262563 DOI: 10.18632/oncotarget.21871  0.44
2017 Zeng L, Wang WH, Arrington J, Shao G, Geahlen RL, Hu CD, Tao WA. Identification of Upstream Kinases by Fluorescence Complementation Mass Spectrometry. Acs Central Science. 3: 1078-1085. PMID 29104924 DOI: 10.1021/acscentsci.7b00261  0.44
2017 Efremov YM, Wang WH, Hardy SD, Geahlen RL, Raman A. Measuring nanoscale viscoelastic parameters of cells directly from AFM force-displacement curves. Scientific Reports. 7: 1541. PMID 28484282 DOI: 10.1038/s41598-017-01784-3  0.44
2015 Krisenko MO, Higgins RL, Ghosh S, Zhou Q, Trybula JS, Wang WH, Geahlen RL. Syk is Recruited to Stress Granules and Promotes their Clearance through Autophagy. The Journal of Biological Chemistry. PMID 26429917 DOI: 10.1074/jbc.M115.642900  0.48
2015 Cartagena-Rivera AX, Wang WH, Geahlen RL, Raman A. Fast, multi-frequency, and quantitative nanomechanical mapping of live cells using the atomic force microscope. Scientific Reports. 5: 11692. PMID 26118423 DOI: 10.1038/srep11692  0.48
2015 Iliuk A, Jayasundera K, Wang WH, Schluttenhofer R, Geahlen RL, Tao WA. In-Depth Analyses of B Cell Signaling Through Tandem Mass Spectrometry of Phosphopeptides Enriched by PolyMAC. International Journal of Mass Spectrometry. 377: 744-753. PMID 25954137 DOI: 10.1016/j.ijms.2014.08.032  0.48
2015 Krisenko MO, Cartagena A, Raman A, Geahlen RL. Nanomechanical property maps of breast cancer cells as determined by multiharmonic atomic force microscopy reveal Syk-dependent changes in microtubule stability mediated by MAP1B. Biochemistry. 54: 60-8. PMID 24914616 DOI: 10.1021/bi500325n  0.48
2014 Wang WH, Childress MO, Geahlen RL. Syk interacts with and phosphorylates nucleolin to stabilize Bcl-x(L) mRNA and promote cell survival. Molecular and Cellular Biology. 34: 3788-99. PMID 25092868 DOI: 10.1128/MCB.00937-14  0.44
2014 Jayasundera KB, Iliuk AB, Nguyen A, Higgins R, Geahlen RL, Tao WA. Global phosphoproteomics of activated B cells using complementary metal ion functionalized soluble nanopolymers. Analytical Chemistry. 86: 6363-71. PMID 24905233 DOI: 10.1021/ac500599r  0.48
2013 Huang R, Oh H, Arrendale A, Martin VA, Galan J, Workman EJ, Stout JR, Walczak CE, Tao WA, Borch RF, Geahlen RL. Intracellular targets for a phosphotyrosine peptidomimetic include the mitotic kinesin, MCAK. Biochemical Pharmacology. 86: 597-611. PMID 23830822 DOI: 10.1016/j.bcp.2013.06.024  0.48
2013 Xue L, Geahlen RL, Tao WA. Identification of direct tyrosine kinase substrates based on protein kinase assay-linked phosphoproteomics. Molecular & Cellular Proteomics : McP. 12: 2969-80. PMID 23793017 DOI: 10.1074/mcp.O113.027722  0.44
2013 Fei B, Yu S, Geahlen RL. Modulation by Syk of Bcl-2, calcium and the calpain-calpastatin proteolytic system in human breast cancer cells. Biochimica Et Biophysica Acta. 1833: 2153-64. PMID 23684705 DOI: 10.1016/j.bbamcr.2013.05.010  0.72
2013 Hu L, Yang L, Lipchik AM, Geahlen RL, Parker LL, Tao WA. A quantitative proteomics-based competition binding assay to characterize pITAM-protein interactions. Analytical Chemistry. 85: 5071-7. PMID 23611696 DOI: 10.1021/ac400359t  0.48
2013 Yu S, Huang H, Iliuk A, Wang WH, Jayasundera KB, Tao WA, Post CB, Geahlen RL. Syk inhibits the activity of protein kinase A by phosphorylating tyrosine 330 of the catalytic subunit. The Journal of Biological Chemistry. 288: 10870-81. PMID 23447535 DOI: 10.1074/jbc.M112.426130  0.48
2012 Pan L, Iliuk A, Yu S, Geahlen RL, Tao WA. Multiplexed quantitation of protein expression and phosphorylation based on functionalized soluble nanopolymers. Journal of the American Chemical Society. 134: 18201-4. PMID 23088311 DOI: 10.1021/ja308453m  0.48
2012 Lipchik AM, Killins RL, Geahlen RL, Parker LL. A peptide-based biosensor assay to detect intracellular Syk kinase activation and inhibition. Biochemistry. 51: 7515-24. PMID 22920457 DOI: 10.1021/bi300970h  0.48
2012 Arrendale A, Kim K, Choi JY, Li W, Geahlen RL, Borch RF. Synthesis of a phosphoserine mimetic prodrug with potent 14-3-3 protein inhibitory activity. Chemistry & Biology. 19: 764-71. PMID 22726690 DOI: 10.1016/j.chembiol.2012.05.011  0.48
2012 Xue L, Wang WH, Iliuk A, Hu L, Galan JA, Yu S, Hans M, Geahlen RL, Tao WA. Sensitive kinase assay linked with phosphoproteomics for identifying direct kinase substrates. Proceedings of the National Academy of Sciences of the United States of America. 109: 5615-20. PMID 22451900 DOI: 10.1073/pnas.1119418109  0.48
2012 Martin VA, Wang WH, Lipchik AM, Parker LL, He Y, Zhang S, Zhang ZY, Geahlen RL. Akt2 inhibits the activation of NFAT in lymphocytes by modulating calcium release from intracellular stores. Cellular Signalling. 24: 1064-73. PMID 22261254 DOI: 10.1016/j.cellsig.2012.01.001  0.48
2012 Moon KD, Zhang X, Zhou Q, Geahlen RL. The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2. Biochimica Et Biophysica Acta. 1823: 199-205. PMID 22019427 DOI: 10.1016/j.bbamcr.2011.10.001  0.48
2011 Chen CH, Martin VA, Gorenstein NM, Geahlen RL, Post CB. Two closely spaced tyrosines regulate NFAT signaling in B cells via Syk association with Vav. Molecular and Cellular Biology. 31: 2984-96. PMID 21606197 DOI: 10.1128/MCB.05043-11  0.48
2011 Galan JA, Paris LL, Zhang HJ, Adler J, Geahlen RL, Tao WA. Proteomic studies of Syk-interacting proteins using a novel amine-specific isotope tag and GFP nanotrap. Journal of the American Society For Mass Spectrometry. 22: 319-28. PMID 21472591 DOI: 10.1007/s13361-010-0030-7  0.48
2010 Paris LL, Hu J, Galan J, Ong SS, Martin VA, Ma H, Tao WA, Harrison ML, Geahlen RL. Regulation of Syk by phosphorylation on serine in the linker insert. The Journal of Biological Chemistry. 285: 39844-54. PMID 20956537 DOI: 10.1074/jbc.M110.164509  0.48
2010 Wang J, Fei B, Zhan Y, Geahlen RL, Lu C. Kinetics of NF-κB nucleocytoplasmic transport probed by single-cell screening without imaging. Lab On a Chip. 10: 2911-6. PMID 20835431 DOI: 10.1039/c0lc00094a  0.72
2010 Wang J, Fei B, Geahlen RL, Lu C. Quantitative analysis of protein translocations by microfluidic total internal reflection fluorescence flow cytometry. Lab On a Chip. 10: 2673-9. PMID 20820633 DOI: 10.1039/c0lc00131g  0.72
2010 Iliuk AB, Martin VA, Alicie BM, Geahlen RL, Tao WA. In-depth analyses of kinase-dependent tyrosine phosphoproteomes based on metal ion-functionalized soluble nanopolymers. Molecular & Cellular Proteomics : McP. 9: 2162-72. PMID 20562096 DOI: 10.1074/mcp.M110.000091  0.48
2010 Zhan Y, Martin VA, Geahlen RL, Lu C. One-step extraction of subcellular proteins from eukaryotic cells. Lab On a Chip. 10: 2046-8. PMID 20548993 DOI: 10.1039/c005152g  0.48
2009 Zhang X, Shrikhande U, Alicie BM, Zhou Q, Geahlen RL. Role of the protein tyrosine kinase Syk in regulating cell-cell adhesion and motility in breast cancer cells. Molecular Cancer Research : McR. 7: 634-44. PMID 19435818 DOI: 10.1158/1541-7786.MCR-08-0371  0.44
2008 Wang J, Bao N, Paris LL, Geahlen RL, Lu C. Total internal reflection fluorescence flow cytometry. Analytical Chemistry. 80: 9840-4. PMID 19007249 DOI: 10.1021/ac801940w  0.48
2008 Wang J, Bao N, Paris LL, Wang HY, Geahlen RL, Lu C. Detection of kinase translocation using microfluidic electroporative flow cytometry. Analytical Chemistry. 80: 1087-93. PMID 18154306 DOI: 10.1021/ac702065e  0.48
2008 Lebouvier T, Scales TM, Hanger DP, Geahlen RL, Lardeux B, Reynolds CH, Anderton BH, Derkinderen P. The microtubule-associated protein tau is phosphorylated by Syk. Biochimica Et Biophysica Acta. 1783: 188-92. PMID 18070606 DOI: 10.1016/j.bbamcr.2007.11.005  0.48
2008 Li M, Ong SS, Rajwa B, Thieu VT, Geahlen RL, Harrison ML. The SH3 domain of Lck modulates T-cell receptor-dependent activation of extracellular signal-regulated kinase through activation of Raf-1. Molecular and Cellular Biology. 28: 630-41. PMID 17998336 DOI: 10.1128/MCB.00150-07  0.48
2007 Oh H, Ozkirimli E, Shah K, Harrison ML, Geahlen RL. Generation of an analog-sensitive Syk tyrosine kinase for the study of signaling dynamics from the B cell antigen receptor. The Journal of Biological Chemistry. 282: 33760-8. PMID 17913708 DOI: 10.1074/jbc.M704846200  0.48
2007 Zhou F, Galan J, Geahlen RL, Tao WA. A novel quantitative proteomics strategy to study phosphorylation-dependent peptide-protein interactions. Journal of Proteome Research. 6: 133-40. PMID 17203957 DOI: 10.1021/pr0602904  0.48
2006 Garrido-Hernandez H, Moon KD, Geahlen RL, Borch RF. Design and synthesis of phosphotyrosine peptidomimetic prodrugs. Journal of Medicinal Chemistry. 49: 3368-76. PMID 16722656 DOI: 10.1021/jm060142p  0.48
2006 Zhou F, Hu J, Ma H, Harrison ML, Geahlen RL. Nucleocytoplasmic trafficking of the Syk protein tyrosine kinase. Molecular and Cellular Biology. 26: 3478-91. PMID 16611990 DOI: 10.1128/MCB.26.9.3478-3491.2006  0.48
2005 Morefield GL, Jiang D, Romero-Mendez IZ, Geahlen RL, Hogenesch H, Hem SL. Effect of phosphorylation of ovalbumin on adsorption by aluminum-containing adjuvants and elution upon exposure to interstitial fluid. Vaccine. 23: 1502-6. PMID 15670886 DOI: 10.1016/j.vaccine.2004.08.048  0.48
2005 Moon KD, Post CB, Durden DL, Zhou Q, De P, Harrison ML, Geahlen RL. Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase. The Journal of Biological Chemistry. 280: 1543-51. PMID 15536084 DOI: 10.1074/jbc.M407805200  0.48
2005 Zheng Y, Balakrishnan V, Buzzard G, Geahlen R, Harrison M, Rundell A. Modeling and analysis of early events in T-lymphocyte antigen-activated intracellular-signaling pathways Journal of Computational and Applied Mathematics. 184: 320-341. DOI: 10.1016/j.cam.2004.08.015  0.48
2004 Moore LL, Fulton AM, Harrison ML, Geahlen RL. Anti-sulfonylbenzoate antibodies as a tool for the detection of nucleotide-binding proteins for functional proteomics. Journal of Proteome Research. 3: 1184-90. PMID 15595727 DOI: 10.1021/pr0498943  0.48
2004 Geahlen RL, Handley MD, Harrison ML. Molecular interdiction of Src-family kinase signaling in hematopoietic cells. Oncogene. 23: 8024-32. PMID 15489920 DOI: 10.1038/sj.onc.1208078  0.48
2004 Zolodz MD, Wood KV, Regnier FE, Geahlen RL. New approach for analysis of the phosphotyrosine proteome and its application to the chicken B cell line, DT40. Journal of Proteome Research. 3: 743-50. PMID 15359727 DOI: 10.1021/pr049967i  0.48
2002 Hong JJ, Yankee TM, Harrison ML, Geahlen RL. Regulation of signaling in B cells through the phosphorylation of Syk on linker region tyrosines. A mechanism for negative signaling by the Lyn tyrosine kinase. The Journal of Biological Chemistry. 277: 31703-14. PMID 12077122 DOI: 10.1074/jbc.M201362200  0.48
2002 Hawash IY, Hu XE, Adal A, Cassady JM, Geahlen RL, Harrison ML. The oxygen-substituted palmitic acid analogue, 13-oxypalmitic acid, inhibits Lck localization to lipid rafts and T cell signaling. Biochimica Et Biophysica Acta. 1589: 140-50. PMID 12007789 DOI: 10.1016/S0167-4889(02)00165-9  0.48
2002 Kesavan KP, Isaacson CC, Ashendel CL, Geahlen RL, Harrison ML. Characterization of the in vivo sites of serine phosphorylation on Lck identifying serine 59 as a site of mitotic phosphorylation. The Journal of Biological Chemistry. 277: 14666-73. PMID 11847223 DOI: 10.1074/jbc.M111911200  0.48
2002 Hawash IY, Kesavan KP, Magee AI, Geahlen RL, Harrison ML. The Lck SH3 domain negatively regulates localization to lipid rafts through an interaction with c-Cbl. The Journal of Biological Chemistry. 277: 5683-91. PMID 11741956 DOI: 10.1074/jbc.M110002200  0.48
2001 Zhou YJ, Chen M, Cusack NA, Kimmel LH, Magnuson KS, Boyd JG, Lin W, Roberts JL, Lengi A, Buckley RH, Geahlen RL, Candotti F, Gadina M, Changelian PS, O'Shea JJ. Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases. Molecular Cell. 8: 959-69. PMID 11741532 DOI: 10.1016/S1097-2765(01)00398-7  0.48
2001 Mu F, Coffing SL, Riese DJ, Geahlen RL, Verdier-Pinard P, Hamel TE, Johnson J, Cushman M. Design, synthesis, and biological evaluation of a series of lavendustin A analogues that inhibit EGFR and Syk tyrosine kinases, as well as tubulin polymerization. Journal of Medicinal Chemistry. 44: 441-52. PMID 11462983 DOI: 10.1021/jm000387g  0.48
2001 Ma H, Yankee TM, Hu J, Asai DJ, Harrison ML, Geahlen RL. Visualization of Syk-antigen receptor interactions using green fluorescent protein: differential roles for Syk and Lyn in the regulation of receptor capping and internalization. Journal of Immunology (Baltimore, Md. : 1950). 166: 1507-16. PMID 11160190 DOI: 10.4049/jimmunol.166.3.1507  0.36
2000 Zhou YJ, Magnuson KS, Cheng TP, Gadina M, Frucht DM, Galon J, Candotti F, Geahlen RL, Changelian PS, O'Shea JJ. Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: Activation of Syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation Molecular and Cellular Biology. 20: 4371-4380. PMID 10825200 DOI: 10.1128/MCB.20.12.4371-4380.2000  0.48
2000 Gaul BS, Harrison ML, Geahlen RL, Burton RA, Post CB. Substrate recognition by the Lyn protein-tyrosine kinase: NMR structure of the immunoreceptor-tyrosine-based activation motif signaling region of the B cell antigen receptor Journal of Biological Chemistry. 275: 16174-16182. PMID 10748115 DOI: 10.1074/jbc.M909044199  0.48
1999 Miller LA, Hong JJ, Kinch MS, Harrison ML, Geahlen RL. The engagement of beta1 integrins on promonocytic cells promotes phosphorylation of Syk and formation of a protein complex containing Lyn and beta1 integrin. European Journal of Immunology. 29: 1426-34. PMID 10359096 DOI: 10.1002/(SICI)1521-4141(199905)29:05<1426::AID-IMMU1426>3.0.CO;2-J  0.48
1999 Stupack DG, Li E, Silletti SA, Kehler JA, Geahlen RL, Hahn K, Nemerow GR, Cheresh DA. Matrix valency regulates integrin-mediated lymphoid adhesion via Syk kinase Journal of Cell Biology. 144: 777-787. PMID 10037798 DOI: 10.1083/jcb.144.4.777  0.48
1999 Fernandez JA, Keshvara LM, Peters JD, Furlong MT, Harrison ML, Geahlen RL. Phosphorylation- and activation-independent association of the tyrosine kinase Syk and the tyrosine kinase substrates Cbl and Vav with tubulin in B-cells. The Journal of Biological Chemistry. 274: 1401-6. PMID 9880513 DOI: 10.1074/jbc.274.3.1401  0.36
1998 McVicar DW, Taylor LS, Gosselin P, Willette-Brown J, Mikhael AI, Geahlen RL, Nakamura MC, Linnemeyer P, Seaman WE, Anderson SK, Ortaldo JR, Mason LH. DAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinase. The Journal of Biological Chemistry. 273: 32934-42. PMID 9830044 DOI: 10.1074/jbc.273.49.32934  0.48
1997 Furlong MT, Mahrenholz AM, Kim KH, Ashendel CL, Harrison ML, Geahlen RL. Identification of the major sites of autophosphorylation of the murine protein-tyrosine kinase Syk. Biochimica Et Biophysica Acta. 1355: 177-90. PMID 9042338 DOI: 10.1016/S0167-4889(96)00131-0  0.36
1996 Peters JD, Furlong MT, Asai DJ, Harrison ML, Geahlen RL. Syk, activated by cross-linking the B-cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates alpha-tubulin on tyrosine. The Journal of Biological Chemistry. 271: 4755-62. PMID 8617742 DOI: 10.1074/jbc.271.9.4755  0.36
1993 Leprince C, Draves KE, Geahlen RL, Ledbetter JA, Clark EA. CD22 associates with the human surface IgM-B-cell antigen receptor complex Proceedings of the National Academy of Sciences of the United States of America. 90: 3236-3240. PMID 8475064 DOI: 10.1073/pnas.90.8.3236  0.48
1993 Atherton-Fessler S, Parker LL, Geahlen RL, Piwnica-Worms H. Mechanisms of p34cdc2 regulation. Molecular and Cellular Biology. 13: 1675-85. PMID 8441405 DOI: 10.1128/MCB.13.3.1675  0.48
1992 Harrison ML, Rathinavelu P, Arese P, Geahlen RL, Low PS. The effect of mild oxidants on glycolysis in human erythrocytes. The Biochemical Journal. 283: 622-3. PMID 1575707 DOI: 10.1042/bj2830622  0.36
1992 Hutchcroft JE, Geahlen RL, Deanin GG, Oliver JM. FcεRI-mediated tyrosine phosphorylation and activation of the 72-kDa protein-tyrosine kinase, PTK72, in RBL-2H3 rat tumor mast cells Proceedings of the National Academy of Sciences of the United States of America. 89: 9107-9111. PMID 1409610 DOI: 10.1073/pnas.89.19.9107  0.48
1988 Mahrenholz AM, Votaw P, Roach PJ, Depaoli-Roach AA, Zioncheck TF, Harrison ML, Geahlen RL. Phosphorylation of glycogen synthase by a bovine thymus protein-tyrosine kinase, p40 Biochemical and Biophysical Research Communications. 155: 52-58. PMID 3137939 DOI: 10.1016/S0006-291X(88)81048-9  0.48
1985 Mason DL, Harrison ML, Geahlen RL. Properties of a tyrosine protein kinase from calf thymus. Response to ionic strength and divalent cations. Biochimica Et Biophysica Acta. 829: 221-8. PMID 3873256 DOI: 10.1016/0167-4838(85)90191-8  0.48
1982 Geahlen RL, Carmichael DF, Hashimoto E, Krebs EG. Phosphorylation of cAMP-dependent protein kinase subunits. Advances in Enzyme Regulation. 20: 195-209. PMID 6287816 DOI: 10.1016/0065-2571(82)90016-4  0.48
1979 Geahlen RL, Haley BE, Krebs EG. Synthesis and use of 8-azidoguanosine 3',5'-cyclic monophosphate as photoaffinity label for cyclic GMP-dependent protein kinase. Proceedings of the National Academy of Sciences of the United States of America. 76: 2213-7. PMID 221918  0.48
1979 Czarnecki J, Geahlen R, Haley B. [58] Synthesis and use of azido photoaffinity analogs of adenine and guanine nucleotides Methods in Enzymology. 56: 642-653. DOI: 10.1016/0076-6879(79)56061-3  0.48
1977 Geahlen RL, Haley BE. Interactions of a photoaffinity analog of GTP with the proteins of microtubules Proceedings of the National Academy of Sciences of the United States of America. 74: 4375-4377. PMID 270679  0.48
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