Mark A. Lemmon - Publications

University of Pennsylvania, Philadelphia, PA, United States 
Medical Biophysics, Molecular Biology, Biochemistry

124 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Patil K, Jordan EJ, Park JH, Suresh K, Smith CM, Lemmon AA, Mossé YP, Lemmon MA, Radhakrishnan R. Computational studies of anaplastic lymphoma kinase mutations reveal common mechanisms of oncogenic activation. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33674381 DOI: 10.1073/pnas.2019132118  0.56
2020 Artim SC, Kiyatkin A, Lemmon MA. Comparison of tyrosine kinase domain properties for the neurotrophin receptors TrkA and TrkB. The Biochemical Journal. PMID 33043964 DOI: 10.1042/BCJ20200695  0.68
2020 Kiyatkin A, van Alderwerelt van Rosenburgh IK, Klein DE, Lemmon MA. Kinetics of receptor tyrosine kinase activation define ERK signaling dynamics. Science Signaling. 13. PMID 32817373 DOI: 10.1126/scisignal.aaz5267  0.68
2020 Sheetz JB, Mathea S, Karvonen H, Malhotra K, Chatterjee D, Niininen W, Perttilä R, Preuss F, Suresh K, Stayrook SE, Tsutsui Y, Radhakrishnan R, Ungureanu D, Knapp S, Lemmon MA. Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases. Molecular Cell. PMID 32619402 DOI: 10.1016/j.molcel.2020.06.018  1
2020 Ferguson KM, Hu C, Lemmon MA. Insulin and EGF receptor family members share parallel activation mechanisms. Protein Science : a Publication of the Protein Society. PMID 32297376 DOI: 10.1002/pro.3871  0.68
2020 Starrett JH, Guernet AA, Cuomo ME, Poels KE, van Alderwerelt van Rosenburgh IK, Nagelberg A, Farnsworth D, Price KS, Khan H, Ashtekar KD, Gaefele M, Ayeni D, Stewart TF, Kuhlmann A, Kaech S, ... ... Lemmon MA, et al. Drug sensitivity and allele-specificity of first-line osimertinib resistance EGFR mutations. Cancer Research. PMID 32193290 DOI: 10.1158/0008-5472.CAN-19-3819  0.68
2019 Truini A, Starrett JH, Stewart TF, Ashtekar KD, Walther Z, Wurtz A, Lu D, Park JH, DeVeaux M, Song X, Gettinger S, Zelterman D, Lemmon MA, Goldberg SB, Politi K. The EGFR Exon 19 Mutant L747-A750>P Exhibits Distinct Sensitivity to Tyrosine Kinase Inhibitors in Lung Adenocarcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31182434 DOI: 10.1158/1078-0432.CCR-19-0780  0.56
2019 Jordan EJ, Patil K, Suresh K, Park JH, Mosse YP, Lemmon MA, Radhakrishnan R. Computational algorithms for in silico profiling of activating mutations in cancer. Cellular and Molecular Life Sciences : Cmls. PMID 30982079 DOI: 10.1007/s00018-019-03097-2  0.56
2018 Sheetz JB, Lemmon MA. Flipping ATP to AMPlify Kinase Functions. Cell. 175: 641-642. PMID 30340038 DOI: 10.1016/j.cell.2018.10.011  1
2018 Emptage RP, Lemmon MA, Ferguson KM, Marmorstein R. Structural Basis for MARK1 Kinase Autoinhibition by Its KA1 Domain. Structure (London, England : 1993). 26: 1137-1143.e3. PMID 30099988 DOI: 10.1016/j.str.2018.05.008  0.68
2018 Liu L, Thaker TM, Freed DM, Frazier N, Malhotra K, Lemmon MA, Jura N. Regulation of Kinase Activity in the Caenorhabditis elegans EGF Receptor, LET-23. Structure (London, England : 1993). PMID 29358026 DOI: 10.1016/j.str.2017.12.012  0.32
2018 Lee S, Choi J, Mohanty J, Sousa LP, Tome F, Pardon E, Steyaert J, Lemmon MA, Lax I, Schlessinger J. Structures of β-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling. Nature. PMID 29342135 DOI: 10.1038/nature25010  1
2017 Freed DM, Bessman NJ, Kiyatkin A, Salazar-Cavazos E, Byrne PO, Moore JO, Valley CC, Ferguson KM, Leahy DJ, Lidke DS, Lemmon MA. EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics. Cell. PMID 28988771 DOI: 10.1016/j.cell.2017.09.017  0.68
2017 Moore JO, Lemmon MA, Ferguson KM. Dimerization of Tie2 mediated by its membrane-proximal FNIII domains. Proceedings of the National Academy of Sciences of the United States of America. PMID 28396397 DOI: 10.1073/pnas.1617800114  0.68
2016 Emptage RP, Lemmon MA, Ferguson KM. Molecular determinants of KA1 domain-mediated autoinhibition and phospholipid activation of MARK1 kinase. The Biochemical Journal. PMID 27879374 DOI: 10.1042/BCJ20160792  0.68
2016 Novotny CJ, Pollari S, Park JH, Lemmon MA, Shen W, Shokat KM. Overcoming resistance to HER2 inhibitors through state-specific kinase binding. Nature Chemical Biology. 12: 923-930. PMID 27595329 DOI: 10.1038/nchembio.2171  0.56
2016 Freed DM, Park JH, Radhakrishnan R, Lemmon MA. Deletion Mutations Keep Kinase Inhibitors in the Loop. Cancer Cell. 29: 423-5. PMID 27070691 DOI: 10.1016/j.ccell.2016.03.017  1
2016 Lemmon MA, Freed DM, Schlessinger J, Kiyatkin A. The Dark Side of Cell Signaling: Positive Roles for Negative Regulators. Cell. 164: 1172-1184. PMID 26967284 DOI: 10.1016/j.cell.2016.02.047  1
2015 Infarinato NR, Park JH, Krytska K, Ryles HT, Sano R, Szigety KM, Li Y, Zou HY, Lee NV, Smeal T, Lemmon MA, Mosse YP. The ALK/ROS1 inhibitor PF-06463922 overcomes primary resistance to crizotinib in ALK-driven neuroblastoma. Cancer Discovery. PMID 26554404 DOI: 10.1158/2159-8290.CD-15-1056  1
2015 Freed DM, Alvarado D, Lemmon MA. Ligand regulation of a constitutively dimeric EGF receptor. Nature Communications. 6: 7380. PMID 26060020 DOI: 10.1038/ncomms8380  1
2015 Moravcevic K, Alvarado D, Schmitz KR, Kenniston JA, Mendrola JM, Ferguson KM, Lemmon MA. Comparison of Saccharomyces cerevisiae F-BAR domain structures reveals a conserved inositol phosphate binding site. Structure (London, England : 1993). 23: 352-63. PMID 25620000 DOI: 10.1016/j.str.2014.12.009  1
2014 Bresler SC, Weiser DA, Huwe PJ, Park JH, Krytska K, Ryles H, Laudenslager M, Rappaport EF, Wood AC, McGrady PW, Hogarty MD, London WB, Radhakrishnan R, Lemmon MA, Mossé YP. ALK mutations confer differential oncogenic activation and sensitivity to ALK inhibition therapy in neuroblastoma. Cancer Cell. 26: 682-94. PMID 25517749 DOI: 10.1016/j.ccell.2014.09.019  1
2014 Bessman NJ, Freed DM, Lemmon MA. Putting together structures of epidermal growth factor receptors. Current Opinion in Structural Biology. 29: 95-101. PMID 25460273 DOI: 10.1016/  1
2014 Bessman NJ, Bagchi A, Ferguson KM, Lemmon MA. Complex relationship between ligand binding and dimerization in the epidermal growth factor receptor. Cell Reports. 9: 1306-17. PMID 25453753 DOI: 10.1016/j.celrep.2014.10.010  1
2014 Fayngerts SA, Wu J, Oxley CL, Liu X, Vourekas A, Cathopoulis T, Wang Z, Cui J, Liu S, Sun H, Lemmon MA, Zhang L, Shi Y, Chen YH. TIPE3 is the transfer protein of lipid second messengers that promote cancer. Cancer Cell. 26: 465-78. PMID 25242044 DOI: 10.1016/j.ccr.2014.07.025  0.52
2014 Lemmon MA, Schlessinger J, Ferguson KM. The EGFR family: not so prototypical receptor tyrosine kinases. Cold Spring Harbor Perspectives in Biology. 6: a020768. PMID 24691965 DOI: 10.1101/cshperspect.a020768  1
2013 Red Brewer M, Yun CH, Lai D, Lemmon MA, Eck MJ, Pao W. Mechanism for activation of mutated epidermal growth factor receptors in lung cancer. Proceedings of the National Academy of Sciences of the United States of America. 110: E3595-604. PMID 24019492 DOI: 10.1073/pnas.1220050110  1
2013 Mendrola JM, Shi F, Park JH, Lemmon MA. Receptor tyrosine kinases with intracellular pseudokinase domains. Biochemical Society Transactions. 41: 1029-36. PMID 23863174 DOI: 10.1042/BST20130104  1
2012 Park JH, Liu Y, Lemmon MA, Radhakrishnan R. Erlotinib binds both inactive and active conformations of the EGFR tyrosine kinase domain. The Biochemical Journal. 448: 417-23. PMID 23101586 DOI: 10.1042/BJ20121513  0.56
2012 Artim SC, Mendrola JM, Lemmon MA. Assessing the range of kinase autoinhibition mechanisms in the insulin receptor family. The Biochemical Journal. 448: 213-20. PMID 22992069 DOI: 10.1042/BJ20121365  0.8
2012 Park JH, Lemmon MA. Occupy EGFR. Cancer Discovery. 2: 398-400. PMID 22588876 DOI: 10.1158/2159-8290.CD-12-0144  0.56
2012 Carpenter EL, Haglund EA, Mace EM, Deng D, Martinez D, Wood AC, Chow AK, Weiser DA, Belcastro LT, Winter C, Bresler SC, Vigny M, Mazot P, Asgharzadeh S, Seeger RC, ... ... Lemmon MA, et al. Antibody targeting of anaplastic lymphoma kinase induces cytotoxicity of human neuroblastoma. Oncogene. 31: 4859-67. PMID 22266870 DOI: 10.1038/onc.2011.647  1
2012 Moravcevic K, Oxley CL, Lemmon MA. Conditional peripheral membrane proteins: facing up to limited specificity. Structure (London, England : 1993). 20: 15-27. PMID 22193136 DOI: 10.1016/j.str.2011.11.012  1
2011 Bresler SC, Wood AC, Haglund EA, Courtright J, Belcastro LT, Plegaria JS, Cole K, Toporovskaya Y, Zhao H, Carpenter EL, Christensen JG, Maris JM, Lemmon MA, Mossé YP. Differential inhibitor sensitivity of anaplastic lymphoma kinase variants found in neuroblastoma. Science Translational Medicine. 3: 108ra114. PMID 22072639 DOI: 10.1126/scitranslmed.3002950  1
2011 Watt B, Tenza D, Lemmon MA, Kerje S, Raposo G, Andersson L, Marks MS. Mutations in or near the transmembrane domain alter PMEL amyloid formation from functional to pathogenic. Plos Genetics. 7: e1002286. PMID 21949659 DOI: 10.1371/journal.pgen.1002286  1
2011 Shi F, Lemmon MA. Biochemistry. KSR plays CRAF-ty. Science (New York, N.Y.). 332: 1043-4. PMID 21617065 DOI: 10.1126/science.1208063  1
2010 Sosa MS, Lopez-Haber C, Yang C, Wang H, Lemmon MA, Busillo JM, Luo J, Benovic JL, Klein-Szanto A, Yagi H, Gutkind JS, Parsons RE, Kazanietz MG. Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer. Molecular Cell. 40: 877-92. PMID 21172654 DOI: 10.1016/j.molcel.2010.11.029  1
2010 Moravcevic K, Mendrola JM, Schmitz KR, Wang YH, Slochower D, Janmey PA, Lemmon MA. Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids Cell. 143: 966-977. PMID 21145462 DOI: 10.1016/j.cell.2010.11.028  1
2010 Alvarado D, Klein DE, Lemmon MA. Structural basis for negative cooperativity in growth factor binding to an EGF receptor. Cell. 142: 568-79. PMID 20723758 DOI: 10.1016/j.cell.2010.07.015  1
2010 Kenniston JA, Lemmon MA. Dynamin GTPase regulation is altered by PH domain mutations found in centronuclear myopathy patients. The Embo Journal. 29: 3054-67. PMID 20700106 DOI: 10.1038/emboj.2010.187  0.32
2010 Lemmon MA, Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell. 141: 1117-34. PMID 20602996 DOI: 10.1016/j.cell.2010.06.011  1
2010 Shi F, Telesco SE, Liu Y, Radhakrishnan R, Lemmon MA. ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 107: 7692-7. PMID 20351256 DOI: 10.1073/pnas.1002753107  1
2009 Watt B, van Niel G, Fowler DM, Hurbain I, Luk KC, Stayrook SE, Lemmon MA, Raposo G, Shorter J, Kelly JW, Marks MS. N-terminal domains elicit formation of functional Pmel17 amyloid fibrils. The Journal of Biological Chemistry. 284: 35543-55. PMID 19840945 DOI: 10.1074/jbc.M109.047449  1
2009 Alvarado D, Klein DE, Lemmon MA. ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor. Nature. 461: 287-91. PMID 19718021 DOI: 10.1038/nature08297  1
2009 Bethoney KA, King MC, Hinshaw JE, Ostap EM, Lemmon MA. A possible effector role for the pleckstrin homology (PH) domain of dynamin. Proceedings of the National Academy of Sciences of the United States of America. 106: 13359-64. PMID 19666604 DOI: 10.1073/pnas.0906945106  1
2009 Red Brewer M, Choi SH, Alvarado D, Moravcevic K, Pozzi A, Lemmon MA, Carpenter G. The juxtamembrane region of the EGF receptor functions as an activation domain. Molecular Cell. 34: 641-51. PMID 19560417 DOI: 10.1016/j.molcel.2009.04.034  1
2009 Nishihama R, Schreiter JH, Onishi M, Vallen EA, Hanna J, Moravcevic K, Lippincott MF, Han H, Lemmon MA, Pringle JR, Bi E. Role of Inn1 and its interactions with Hof1 and Cyk3 in promoting cleavage furrow and septum formation in S. cerevisiae. The Journal of Cell Biology. 185: 995-1012. PMID 19528296 DOI: 10.1083/jcb.200903125  1
2009 Lian L, Wang Y, Flick M, Choi J, Scott EW, Degen J, Lemmon MA, Abrams CS. Loss of pleckstrin defines a novel pathway for PKC-mediated exocytosis. Blood. 113: 3577-84. PMID 19190246 DOI: 10.1182/blood-2008-09-178913  1
2009 Wilson KJ, Gilmore JL, Foley J, Lemmon MA, Riese DJ. Functional selectivity of EGF family peptide growth factors: implications for cancer. Pharmacology & Therapeutics. 122: 1-8. PMID 19135477 DOI: 10.1016/j.pharmthera.2008.11.008  1
2008 Klein DE, Stayrook SE, Shi F, Narayan K, Lemmon MA. Structural basis for EGFR ligand sequestration by Argos. Nature. 453: 1271-5. PMID 18500331 DOI: 10.1038/nature06978  1
2008 Qiu C, Tarrant MK, Choi SH, Sathyamurthy A, Bose R, Banjade S, Pal A, Bornmann WG, Lemmon MA, Cole PA, Leahy DJ. Mechanism of activation and inhibition of the HER4/ErbB4 kinase. Structure (London, England : 1993). 16: 460-7. PMID 18334220 DOI: 10.1016/j.str.2007.12.016  1
2007 Dawson JP, Bu Z, Lemmon MA. Ligand-induced structural transitions in ErbB receptor extracellular domains. Structure (London, England : 1993). 15: 942-54. PMID 17697999 DOI: 10.1016/j.str.2007.06.013  1
2007 Lemmon MA, Ferguson KM. A new twist in the transmembrane signaling tool-kit. Cell. 130: 213-5. PMID 17662934 DOI: 10.1016/j.cell.2007.07.006  1
2006 Schlessinger J, Lemmon MA. Nuclear signaling by receptor tyrosine kinases: the first robin of spring. Cell. 127: 45-8. PMID 17018275 DOI: 10.1016/j.cell.2006.09.013  1
2006 Baumeister MA, Rossman KL, Sondek J, Lemmon MA. The Dbs PH domain contributes independently to membrane targeting and regulation of guanine nucleotide-exchange activity. The Biochemical Journal. 400: 563-72. PMID 17007612 DOI: 10.1042/BJ20061020  1
2006 Choudhury P, Srivastava S, Li Z, Ko K, Albaqumi M, Narayan K, Coetzee WA, Lemmon MA, Skolnik EY. Specificity of the myotubularin family of phosphatidylinositol-3-phosphatase is determined by the PH/GRAM domain. The Journal of Biological Chemistry. 281: 31762-9. PMID 16914545 DOI: 10.1074/jbc.M606344200  0.52
2006 Alvarado D, Evans TA, Sharma R, Lemmon MA, Duffy JB. Argos mutants define an affinity threshold for spitz inhibition in vivo. The Journal of Biological Chemistry. 281: 28993-9001. PMID 16870613 DOI: 10.1074/jbc.M603782200  1
2006 Narayan K, Lemmon MA. Determining selectivity of phosphoinositide-binding domains. Methods (San Diego, Calif.). 39: 122-33. PMID 16829131 DOI: 10.1016/j.ymeth.2006.05.006  1
2006 Ozcan F, Klein P, Lemmon MA, Lax I, Schlessinger J. On the nature of low- and high-affinity EGF receptors on living cells. Proceedings of the National Academy of Sciences of the United States of America. 103: 5735-40. PMID 16571657 DOI: 10.1073/pnas.0601469103  1
2006 Miura GI, Buglino J, Alvarado D, Lemmon MA, Resh MD, Treisman JE. Palmitoylation of the EGFR ligand Spitz by Rasp increases Spitz activity by restricting its diffusion. Developmental Cell. 10: 167-76. PMID 16459296 DOI: 10.1016/j.devcel.2005.11.017  1
2006 Michell RH, Heath VL, Lemmon MA, Dove SK. Phosphatidylinositol 3,5-bisphosphate: metabolism and cellular functions. Trends in Biochemical Sciences. 31: 52-63. PMID 16364647 DOI: 10.1016/j.tibs.2005.11.013  1
2005 Dawson JP, Berger MB, Lin CC, Schlessinger J, Lemmon MA, Ferguson KM. Epidermal growth factor receptor dimerization and activation require ligand-induced conformational changes in the dimer interface. Molecular and Cellular Biology. 25: 7734-42. PMID 16107719 DOI: 10.1128/MCB.25.17.7734-7742.2005  1
2005 Reeves GT, Kalifa R, Klein DE, Lemmon MA, Shvartsman SY. Computational analysis of EGFR inhibition by Argos. Developmental Biology. 284: 523-35. PMID 15982648 DOI: 10.1016/j.ydbio.2005.05.013  1
2005 Flesch FM, Yu JW, Lemmon MA, Burger KN. Membrane activity of the phospholipase C-delta1 pleckstrin homology (PH) domain. The Biochemical Journal. 389: 435-41. PMID 15755258 DOI: 10.1042/BJ20041721  1
2004 Klein DE, Nappi VM, Reeves GT, Shvartsman SY, Lemmon MA. Argos inhibits epidermal growth factor receptor signalling by ligand sequestration. Nature. 430: 1040-4. PMID 15329724 DOI: 10.1038/nature02840  1
2004 Berger MB, Mendrola JM, Lemmon MA. ErbB3/HER3 does not homodimerize upon neuregulin binding at the cell surface. Febs Letters. 569: 332-6. PMID 15225657 DOI: 10.1016/j.febslet.2004.06.014  1
2004 King MC, Raposo G, Lemmon MA. Inhibition of nuclear import and cell-cycle progression by mutated forms of the dynamin-like GTPase MxB. Proceedings of the National Academy of Sciences of the United States of America. 101: 8957-62. PMID 15184662 DOI: 10.1073/pnas.0403167101  1
2004 Dove SK, Piper RC, McEwen RK, Yu JW, King MC, Hughes DC, Thuring J, Holmes AB, Cooke FT, Michell RH, Parker PJ, Lemmon MA. Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors. The Embo Journal. 23: 1922-33. PMID 15103325 DOI: 10.1038/sj.emboj.7600203  1
2004 Yu JW, Mendrola JM, Audhya A, Singh S, Keleti D, DeWald DB, Murray D, Emr SD, Lemmon MA. Genome-wide analysis of membrane targeting by S. cerevisiae pleckstrin homology domains. Molecular Cell. 13: 677-88. PMID 15023338 DOI: 10.1016/S1097-2765(04)00083-8  1
2004 Wild AC, Yu JW, Lemmon MA, Blumer KJ. The p21-activated protein kinase-related kinase Cla4 is a coincidence detector of signaling by Cdc42 and phosphatidylinositol 4-phosphate. The Journal of Biological Chemistry. 279: 17101-10. PMID 14766750 DOI: 10.1074/jbc.M314035200  1
2004 Klein P, Mattoon D, Lemmon MA, Schlessinger J. A structure-based model for ligand binding and dimerization of EGF receptors. Proceedings of the National Academy of Sciences of the United States of America. 101: 929-34. PMID 14732694 DOI: 10.1073/pnas.0307285101  1
2004 Mattoon D, Klein P, Lemmon MA, Lax I, Schlessinger J. The tethered configuration of the EGF receptor extracellular domain exerts only a limited control of receptor function. Proceedings of the National Academy of Sciences of the United States of America. 101: 923-8. PMID 14732693 DOI: 10.1073/pnas.0307286101  1
2003 Burgess AW, Cho HS, Eigenbrot C, Ferguson KM, Garrett TP, Leahy DJ, Lemmon MA, Sliwkowski MX, Ward CW, Yokoyama S. An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors. Molecular Cell. 12: 541-52. PMID 14527402 DOI: 10.1016/S1097-2765(03)00350-2  1
2003 Schlessinger J, Lemmon MA. SH2 and PTB domains in tyrosine kinase signaling. Science's Stke : Signal Transduction Knowledge Environment. 2003: RE12. PMID 12865499 DOI: 10.1126/stke.2003.191.re12  1
2003 Ferguson KM, Berger MB, Mendrola JM, Cho HS, Leahy DJ, Lemmon MA. EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization. Molecular Cell. 11: 507-17. PMID 12620237 DOI: 10.1016/S1097-2765(03)00047-9  1
2003 Yu JW, Lemmon MA. Genome-wide analysis of signaling domain function. Current Opinion in Chemical Biology. 7: 103-9. PMID 12547434 DOI: 10.1016/S1367-5931(02)00008-X  1
2003 Baumeister MA, Martinu L, Rossman KL, Sondek J, Lemmon MA, Chou MM. Loss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targeting. The Journal of Biological Chemistry. 278: 11457-64. PMID 12525493 DOI: 10.1074/jbc.M211901200  1
2002 Saxena A, Morozov P, Frank D, Musalo R, Lemmon MA, Skolnik EY, Tycko B. Phosphoinositide binding by the pleckstrin homology domains of Ipl and Tih1. The Journal of Biological Chemistry. 277: 49935-44. PMID 12374806 DOI: 10.1074/jbc.M206497200  0.44
2002 Nasuhoglu C, Feng S, Mao Y, Shammat I, Yamamato M, Earnest S, Lemmon M, Hilgemann DW. Modulation of cardiac PIP2 by cardioactive hormones and other physiologically relevant interventions. American Journal of Physiology. Cell Physiology. 283: C223-34. PMID 12055091 DOI: 10.1152/ajpcell.00486.2001  1
2002 Aasland R, Abrams C, Ampe C, Ball LJ, Bedford MT, Cesareni G, Gimona M, Hurley JH, Jarchau T, Lehto VP, Lemmon MA, Linding R, Mayer BJ, Nagai M, Sudol M, et al. Normalization of nomenclature for peptide motifs as ligands of modular protein domains. Febs Letters. 513: 141-4. PMID 11911894 DOI: 10.1016/S0014-5793(01)03295-1  1
2002 Lemmon MA, Ferguson KM, Abrams CS. Pleckstrin homology domains and the cytoskeleton. Febs Letters. 513: 71-6. PMID 11911883 DOI: 10.1016/S0014-5793(01)03243-4  1
2002 Mendrola JM, Berger MB, King MC, Lemmon MA. The single transmembrane domains of ErbB receptors self-associate in cell membranes. The Journal of Biological Chemistry. 277: 4704-12. PMID 11741943 DOI: 10.1074/jbc.M108681200  1
2001 Snyder JT, Rossman KL, Baumeister MA, Pruitt WM, Siderovski DP, Der CJ, Lemmon MA, Sondek J. Quantitative analysis of the effect of phosphoinositide interactions on the function of Dbl family proteins. The Journal of Biological Chemistry. 276: 45868-75. PMID 11577097 DOI: 10.1074/jbc.M106731200  1
2001 Yu JW, Lemmon MA. All phox homology (PX) domains from Saccharomyces cerevisiae specifically recognize phosphatidylinositol 3-phosphate. The Journal of Biological Chemistry. 276: 44179-84. PMID 11557775 DOI: 10.1074/jbc.M108811200  1
2001 Lemmon MA, Ferguson KM. Molecular determinants in pleckstrin homology domains that allow specific recognition of phosphoinositides Biochemical Society Transactions. 29: 377-384. PMID 11497993 DOI: 10.1042/BST0290377  1
2001 Sankaran VG, Klein DE, Sachdeva MM, Lemmon MA. High-affinity binding of a FYVE domain to phosphatidylinositol 3-phosphate requires intact phospholipid but not FYVE domain oligomerization. Biochemistry. 40: 8581-7. PMID 11456498 DOI: 10.1021/bi010425d  1
2001 Plotnikov AN, Eliseenkova AV, Ibrahimi OA, Shriver Z, Sasisekharan R, Lemmon MA, Mohammadi M. Crystal structure of fibroblast growth factor 9 reveals regions implicated in dimerization and autoinhibition. The Journal of Biological Chemistry. 276: 4322-9. PMID 11060292 DOI: 10.1074/jbc.M006502200  1
2000 Ferguson KM, Kavran JM, Sankaran VG, Fournier E, Isakoff SJ, Skolnik EY, Lemmon MA. Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains. Molecular Cell. 6: 373-84. PMID 10983984  1
2000 Ferguson KM, Darling PJ, Mohan MJ, Macatee TL, Lemmon MA. Extracellular domains drive homo- but not hetero-dimerization of erbB receptors. The Embo Journal. 19: 4632-43. PMID 10970856 DOI: 10.1093/emboj/19.17.4632  1
1999 Lee A, Frank DW, Marks MS, Lemmon MA. Dominant-negative inhibition of receptor-mediated endocytosis by a dynamin-1 mutant with a defective pleckstrin homology domain. Current Biology : Cb. 9: 261-4. PMID 10074457 DOI: 10.1016/S0960-9822(99)80115-8  1
1998 Jost M, Simpson F, Kavran JM, Lemmon MA, Schmid SL. Phosphatidylinositol-4,5-bisphosphate is required for endocytic coated vesicle formation. Current Biology : Cb. 8: 1399-402. PMID 9889104 DOI: 10.1016/S0960-9822(98)00022-0  1
1998 Kavran JM, Klein DE, Lee A, Falasca M, Isakoff SJ, Skolnik EY, Lemmon MA. Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains. The Journal of Biological Chemistry. 273: 30497-508. PMID 9804818 DOI: 10.1074/jbc.273.46.30497  1
1998 Klein DE, Lee A, Frank DW, Marks MS, Lemmon MA. The pleckstrin homology domains of dynamin isoforms require oligomerization for high affinity phosphoinositide binding. The Journal of Biological Chemistry. 273: 27725-33. PMID 9765310 DOI: 10.1074/jbc.273.42.27725  1
1998 Isakoff SJ, Cardozo T, Andreev J, Li Z, Ferguson KM, Abagyan R, Lemmon MA, Aronheim A, Skolnik EY. Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast. The Embo Journal. 17: 5374-87. PMID 9736615 DOI: 10.1093/emboj/17.18.5374  1
1998 Lemmon MA, Schlessinger J. Transmembrane signaling by receptor oligomerization. Methods in Molecular Biology (Clifton, N.J.). 84: 49-71. PMID 9666441 DOI: 10.1385/0-89603-488-7:49  1
1998 Falasca M, Logan SK, Lehto VP, Baccante G, Lemmon MA, Schlessinger J. Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting. The Embo Journal. 17: 414-22. PMID 9430633 DOI: 10.1093/emboj/17.2.414  1
1997 Artalejo CR, Lemmon MA, Schlessinger J, Palfrey HC. Specific role for the PH domain of dynamin-1 in the regulation of rapid endocytosis in adrenal chromaffin cells. The Embo Journal. 16: 1565-74. PMID 9130701 DOI: 10.1093/emboj/16.7.1565  1
1997 Lemmon MA, Pinchasi D, Zhou M, Lax I, Schlessinger J. Kit receptor dimerization is driven by bivalent binding of stem cell factor. The Journal of Biological Chemistry. 272: 6311-7. PMID 9045650 DOI: 10.1074/jbc.272.10.6311  1
1997 Burke CL, Lemmon MA, Coren BA, Engelman DM, Stern DF. Dimerization of the p185neu transmembrane domain is necessary but not sufficient for transformation. Oncogene. 14: 687-96. PMID 9038376 DOI: 10.1038/sj.onc.1200873  1
1997 Lemmon MA, Bu Z, Ladbury JE, Zhou M, Pinchasi D, Lax I, Engelman DM, Schlessinger J. Two EGF molecules contribute additively to stabilization of the EGFR dimer. The Embo Journal. 16: 281-94. PMID 9029149 DOI: 10.1093/emboj/16.2.281  1
1996 Lemmon MA, Ferguson KM, Schlessinger J. PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface. Cell. 85: 621-4. PMID 8646770 DOI: 10.1016/S0092-8674(00)81022-3  1
1996 Mandiyan V, O'Brien R, Zhou M, Margolis B, Lemmon MA, Sturtevant JM, Schlessinger J. Thermodynamic studies of SHC phosphotyrosine interaction domain recognition of the NPXpY motif. The Journal of Biological Chemistry. 271: 4770-5. PMID 8617744 DOI: 10.1074/jbc.271.9.4770  1
1996 Zheng J, Cahill SM, Lemmon MA, Fushman D, Schlessinger J, Cowburn D. Identification of the binding site for acidic phospholipids on the pH domain of dynamin: implications for stimulation of GTPase activity. Journal of Molecular Biology. 255: 14-21. PMID 8568861 DOI: 10.1006/jmbi.1996.0002  1
1995 Ferguson KM, Lemmon MA, Schlessinger J, Sigler PB. Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain. Cell. 83: 1037-46. PMID 8521504 DOI: 10.1016/0092-8674(95)90219-8  1
1995 Schlessinger J, Lax I, Lemmon M. Regulation of growth factor activation by proteoglycans: what is the role of the low affinity receptors? Cell. 83: 357-60. PMID 8521464 DOI: 10.1016/0092-8674(95)90112-4  1
1995 Fushman D, Cahill S, Lemmon MA, Schlessinger J, Cowburn D. Solution structure of pleckstrin homology domain of dynamin by heteronuclear NMR spectroscopy. Proceedings of the National Academy of Sciences of the United States of America. 92: 816-20. PMID 7846058  1
1995 Lee CH, Leung B, Lemmon MA, Zheng J, Cowburn D, Kuriyan J, Saksela K. A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein Embo Journal. 14: 5006-5015. PMID 7588629  1
1995 Ferguson KM, Lemmon MA, Sigler PB, Schlessinger J. Scratching the surface with the PH domain. Nature Structural Biology. 2: 715-8. PMID 7552736 DOI: 10.1038/nsb0995-715  1
1995 Ladbury JE, Lemmon MA, Zhou M, Green J, Botfield MC, Schlessinger J. Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal. Proceedings of the National Academy of Sciences of the United States of America. 92: 3199-203. PMID 7536927  1
1995 Lemmon MA, Ferguson KM, O'Brien R, Sigler PB, Schlessinger J. Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain. Proceedings of the National Academy of Sciences of the United States of America. 92: 10472-6. PMID 7479822 DOI: 10.1073/pnas.92.23.10472  1
1994 Lemmon MA, Engelman DM. Specificity and promiscuity in membrane helix interactions. Febs Letters. 346: 17-20. PMID 8206151 DOI: 10.1016/0014-5793(94)00467-6  1
1994 Sorokin A, Lemmon MA, Ullrich A, Schlessinger J. Stabilization of an active dimeric form of the epidermal growth factor receptor by introduction of an inter-receptor disulfide bond. The Journal of Biological Chemistry. 269: 9752-9. PMID 8144568  1
1994 Lemmon MA, Engelman DM. Specificity and promiscuity in membrane helix interactions. Quarterly Reviews of Biophysics. 27: 157-218. PMID 7984776  1
1994 Ferguson KM, Lemmon MA, Schlessinger J, Sigler PB. Crystal structure at 2.2 A resolution of the pleckstrin homology domain from human dynamin. Cell. 79: 199-209. PMID 7954789 DOI: 10.1016/0092-8674(94)90190-2  1
1994 Lemmon MA, Schlessinger J. Regulation of signal transduction and signal diversity by receptor oligomerization. Trends in Biochemical Sciences. 19: 459-63. PMID 7855887  1
1994 Lemmon MA, Treutlein HR, Adams PD, Brünger AT, Engelman DM. A dimerization motif for transmembrane alpha-helices. Nature Structural Biology. 1: 157-63. PMID 7656033 DOI: 10.1038/nsb0394-157  1
1994 Spivak-Kroizman T, Lemmon MA, Dikic I, Ladbury JE, Pinchasi D, Huang J, Jaye M, Crumley G, Schlessinger J, Lax I. Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation. Cell. 79: 1015-24. PMID 7528103  1
1994 Lemmon MA, Ladbury JE, Mandiyan V, Zhou M, Schlessinger J. Independent binding of peptide ligands to the SH2 and SH3 domains of Grb2. The Journal of Biological Chemistry. 269: 31653-8. PMID 7527391  1
1994 Arkin IT, Adams PD, MacKenzie KR, Lemmon MA, Brünger AT, Engelman DM. Structural organization of the pentameric transmembrane alpha-helices of phospholamban, a cardiac ion channel. The Embo Journal. 13: 4757-64. PMID 7525269  1
1993 Engelman DM, Adair BD, Brünger A, Flanagan JM, Hunt JF, Lemmon MA, Treutlein H, Zhang J. Dimerization of glycophorin A transmembrane helices: mutagenesis and modeling. Society of General Physiologists Series. 48: 11-21. PMID 8503039  1
1992 Lemmon MA, Flanagan JM, Hunt JF, Adair BD, Bormann BJ, Dempsey CE, Engelman DM. Glycophorin A dimerization is driven by specific interactions between transmembrane alpha-helices. The Journal of Biological Chemistry. 267: 7683-9. PMID 1560003  1
1992 Treutlein HR, Lemmon MA, Engelman DM, Brünger AT. The glycophorin A transmembrane domain dimer: sequence-specific propensity for a right-handed supercoil of helices. Biochemistry. 31: 12726-32. PMID 1463744 DOI: 10.1021/bi00166a003  1
1992 Lemmon MA, Flanagan JM, Treutlein HR, Zhang J, Engelman DM. Sequence specificity in the dimerization of transmembrane α-helices Biochemistry. 31: 12719-12725. PMID 1463743 DOI: 10.1021/bi00166a002  1
1992 Lemmon MA, Engelman DM. Helix-helix interactions inside lipid bilayers Current Opinion in Structural Biology. 2: 511-518. DOI: 10.1016/0959-440X(92)90080-Q  1
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