Richard J. Youle - Publications

Biochemistry and Molecular Genetics The George Washington University, Washington, DC, United States 
Cell Biology, Virology Biology

94 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Lomash RM, Petralia RS, Holtzclaw LA, Tsuda MC, Wang YX, Badger JD, Cameron HA, Youle RJ, Roche KW. Neurolastin, a dynamin family GTPase, translocates to mitochondria upon neuronal stress and alters mitochondrial morphology in vivo. The Journal of Biological Chemistry. PMID 31177092 DOI: 10.1074/jbc.RA118.007245  1
2016 Richter B, Sliter DA, Herhaus L, Stolz A, Wang C, Beli P, Zaffagnini G, Wild P, Martens S, Wagner SA, Youle RJ, Dikic I. Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria. Proceedings of the National Academy of Sciences of the United States of America. PMID 27035970 DOI: 10.1073/pnas.1523926113  1
2016 Sun N, Youle RJ, Finkel T. The Mitochondrial Basis of Aging. Molecular Cell. 61: 654-66. PMID 26942670 DOI: 10.1016/j.molcel.2016.01.028  1
2016 Yao Y, Nisan D, Antignani A, Barnes A, Tjandra N, Youle RJ, Marassi FM, Fujimoto LM. Characterization of the membrane-inserted C-terminus of cytoprotective BCL-XL. Protein Expression and Purification. 122: 56-63. PMID 26923059 DOI: 10.1016/j.pep.2016.02.010  1
2015 Lazarou M, Sliter DA, Kane LA, Sarraf SA, Wang C, Burman JL, Sideris DP, Fogel AI, Youle RJ. The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy. Nature. 524: 309-14. PMID 26266977 DOI: 10.1038/nature14893  1
2015 Lomash RM, Gu X, Youle RJ, Lu W, Roche KW. Neurolastin, a Dynamin Family GTPase, Regulates Excitatory Synapses and Spine Density. Cell Reports. PMID 26212327 DOI: 10.1016/j.celrep.2015.06.064  1
2015 Pickrell AM, Huang CH, Kennedy SR, Ordureau A, Sideris DP, Hoekstra JG, Harper JW, Youle RJ. Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress. Neuron. 87: 371-81. PMID 26182419 DOI: 10.1016/j.neuron.2015.06.034  1
2015 Hasson SA, Fogel AI, Wang C, MacArthur R, Guha R, Heman-Ackah S, Martin S, Youle RJ, Inglese J. Chemogenomic profiling of endogenous PARK2 expression using a genome-edited coincidence reporter. Acs Chemical Biology. 10: 1188-97. PMID 25689131 DOI: 10.1021/cb5010417  1
2014 Kane LA, Lazarou M, Fogel AI, Li Y, Yamano K, Sarraf SA, Banerjee S, Youle RJ. PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity. The Journal of Cell Biology. 205: 143-53. PMID 24751536 DOI: 10.1083/jcb.201402104  1
2014 Yamano K, Fogel AI, Wang C, van der Bliek AM, Youle RJ. Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy. Elife. 3: e01612. PMID 24569479 DOI: 10.7554/eLife.01612  1
2014 Shen Q, Yamano K, Head BP, Kawajiri S, Cheung JT, Wang C, Cho JH, Hattori N, Youle RJ, van der Bliek AM. Mutations in Fis1 disrupt orderly disposal of defective mitochondria. Molecular Biology of the Cell. 25: 145-59. PMID 24196833 DOI: 10.1091/mbc.E13-09-0525  1
2013 Hasson SA, Kane LA, Yamano K, Huang CH, Sliter DA, Buehler E, Wang C, Heman-Ackah SM, Hessa T, Guha R, Martin SE, Youle RJ. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. Nature. 504: 291-5. PMID 24270810 DOI: 10.1038/nature12748  1
2013 Fogel AI, Dlouhy BJ, Wang C, Ryu SW, Neutzner A, Hasson SA, Sideris DP, Abeliovich H, Youle RJ. Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy. Molecular and Cellular Biology. 33: 3675-88. PMID 23878393 DOI: 10.1128/MCB.00079-13  1
2013 Narendra DP, Wang C, Youle RJ, Walker JE. PINK1 rendered temperature sensitive by disease-associated and engineered mutations. Human Molecular Genetics. 22: 2572-89. PMID 23459931 DOI: 10.1093/hmg/ddt106  1
2012 Cooper JP, Youle RJ. Balancing cell growth and death. Current Opinion in Cell Biology. 24: 802-3. PMID 23246130 DOI: 10.1016/  1
2012 Ma J, Edlich F, Bermejo GA, Norris KL, Youle RJ, Tjandra N. Structural mechanism of Bax inhibition by cytomegalovirus protein vMIA. Proceedings of the National Academy of Sciences of the United States of America. 109: 20901-6. PMID 23213219 DOI: 10.1073/pnas.1217094110  1
2012 Lussier MP, Herring BE, Nasu-Nishimura Y, Neutzner A, Karbowski M, Youle RJ, Nicoll RA, Roche KW. Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission. Proceedings of the National Academy of Sciences of the United States of America. 109: 19426-31. PMID 23129617 DOI: 10.1073/pnas.1217477109  1
2012 Narendra D, Walker JE, Youle R. Mitochondrial quality control mediated by PINK1 and Parkin: links to parkinsonism. Cold Spring Harbor Perspectives in Biology. 4. PMID 23125018 DOI: 10.1101/cshperspect.a011338  1
2012 Perciavalle RM, Stewart DP, Koss B, Lynch J, Milasta S, Bathina M, Temirov J, Cleland MM, Pelletier S, Schuetz JD, Youle RJ, Green DR, Opferman JT. Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration Nature Cell Biology. 14: 575-583. PMID 22544066 DOI: 10.1038/ncb2488  1
2012 Sims JJ, Scavone F, Cooper EM, Kane LA, Youle RJ, Boeke JD, Cohen RE. Polyubiquitin-sensor proteins reveal localization and linkage-type dependence of cellular ubiquitin signaling. Nature Methods. 9: 303-9. PMID 22306808 DOI: 10.1038/nmeth.1888  1
2011 Kim KY, Stevens MV, Akter MH, Rusk SE, Huang RJ, Cohen A, Noguchi A, Springer D, Bocharov AV, Eggerman TL, Suen DF, Youle RJ, Amar M, Remaley AT, Sack MN. Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells. The Journal of Clinical Investigation. 121: 3701-12. PMID 21865652 DOI: 10.1172/JCI44736  0.96
2011 Joo JH, Dorsey FC, Joshi A, Hennessy-Walters KM, Rose KL, McCastlain K, Zhang J, Iyengar R, Jung CH, Suen DF, Steeves MA, Yang CY, Prater SM, Kim DH, Thompson CB, ... Youle RJ, et al. Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy. Molecular Cell. 43: 572-85. PMID 21855797 DOI: 10.1016/j.molcel.2011.06.018  1
2011 Karbowski M, Youle RJ. Regulating mitochondrial outer membrane proteins by ubiquitination and proteasomal degradation. Current Opinion in Cell Biology. 23: 476-82. PMID 21705204 DOI: 10.1016/  1
2011 Edlich F, Banerjee S, Suzuki M, Cleland MM, Arnoult D, Wang C, Neutzner A, Tjandra N, Youle RJ. Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol. Cell. 145: 104-16. PMID 21458670 DOI: 10.1016/j.cell.2011.02.034  1
2011 Carelli V, Schimpf S, Fuhrmann N, Valentino ML, Zanna C, Iommarini L, Papke M, Schaich S, Tippmann S, Baumann B, Barboni P, Longanesi L, Rugolo M, Ghelli A, Alavi MV, ... Youle RJ, et al. A clinically complex form of dominant optic atrophy (OPA8) maps on chromosome 16. Human Molecular Genetics. 20: 1893-905. PMID 21349918 DOI: 10.1093/hmg/ddr071  1
2011 Hoppins S, Edlich F, Cleland MM, Banerjee S, McCaffery JM, Youle RJ, Nunnari J. The soluble form of Bax regulates mitochondrial fusion via MFN2 homotypic complexes. Molecular Cell. 41: 150-60. PMID 21255726 DOI: 10.1016/j.molcel.2010.11.030  1
2011 Neutzner A, Neutzner M, Benischke AS, Ryu SW, Frank S, Youle RJ, Karbowski M. A systematic search for endoplasmic reticulum (ER) membrane-associated RING finger proteins identifies Nixin/ZNRF4 as a regulator of calnexin stability and ER homeostasis. The Journal of Biological Chemistry. 286: 8633-43. PMID 21205830 DOI: 10.1074/jbc.M110.197459  1
2011 Cleland MM, Norris KL, Karbowski M, Wang C, Suen DF, Jiao S, George NM, Luo X, Li Z, Youle RJ. Bcl-2 family interaction with the mitochondrial morphogenesis machinery. Cell Death and Differentiation. 18: 235-47. PMID 20671748 DOI: 10.1038/cdd.2010.89  1
2010 Tanaka A, Cleland MM, Xu S, Narendra DP, Suen DF, Karbowski M, Youle RJ. Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin. The Journal of Cell Biology. 191: 1367-80. PMID 21173115 DOI: 10.1083/jcb.201007013  1
2010 Suen DF, Narendra DP, Tanaka A, Manfredi G, Youle RJ. Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells. Proceedings of the National Academy of Sciences of the United States of America. 107: 11835-40. PMID 20547844 DOI: 10.1073/pnas.0914569107  0.96
2010 Du X, Youle RJ, FitzGerald DJ, Pastan I. Pseudomonas exotoxin A-mediated apoptosis is Bak dependent and preceded by the degradation of Mcl-1. Molecular and Cellular Biology. 30: 3444-52. PMID 20457813 DOI: 10.1128/MCB.00813-09  1
2010 Benard G, Neutzner A, Peng G, Wang C, Livak F, Youle RJ, Karbowski M. IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation. The Embo Journal. 29: 1458-71. PMID 20300062 DOI: 10.1038/emboj.2010.39  1
2010 Narendra DP, Jin SM, Tanaka A, Suen DF, Gautier CA, Shen J, Cookson MR, Youle RJ. PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. Plos Biology. 8: e1000298. PMID 20126261 DOI: 10.1371/journal.pbio.1000298  1
2010 Park YY, Lee S, Karbowski M, Neutzner A, Youle RJ, Cho H. Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1. Journal of Cell Science. 123: 619-26. PMID 20103533 DOI: 10.1242/jcs.061481  1
2009 Rostovtseva TK, Boukari H, Antignani A, Shiu B, Banerjee S, Neutzner A, Youle RJ. Bax activates endophilin B1 oligomerization and lipid membrane vesiculation. The Journal of Biological Chemistry. 284: 34390-9. PMID 19805544 DOI: 10.1074/jbc.M109.021873  1
2009 Hardwick JM, Youle RJ. SnapShot: BCL-2 proteins. Cell. 138: 404, 404.e1. PMID 19632186 DOI: 10.1016/j.cell.2009.07.003  1
2009 Narendra D, Tanaka A, Suen DF, Youle RJ. Parkin-induced mitophagy in the pathogenesis of Parkinson disease. Autophagy. 5: 706-8. PMID 19377297  0.96
2009 Tondera D, Grandemange S, Jourdain A, Karbowski M, Mattenberger Y, Herzig S, Da Cruz S, Clerc P, Raschke I, Merkwirth C, Ehses S, Krause F, Chan DC, Alexander C, Bauer C, ... Youle R, et al. SLP-2 is required for stress-induced mitochondrial hyperfusion. The Embo Journal. 28: 1589-600. PMID 19360003 DOI: 10.1038/emboj.2009.89  1
2008 Neutzner A, Benard G, Youle RJ, Karbowski M. Role of the ubiquitin conjugation system in the maintenance of mitochondrial homeostasis. Annals of the New York Academy of Sciences. 1147: 242-53. PMID 19076446 DOI: 10.1196/annals.1427.012  1
2008 Narendra D, Tanaka A, Suen DF, Youle RJ. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. The Journal of Cell Biology. 183: 795-803. PMID 19029340 DOI: 10.1083/jcb.200809125  0.96
2008 Suen DF, Norris KL, Youle RJ. Mitochondrial dynamics and apoptosis. Genes & Development. 22: 1577-90. PMID 18559474 DOI: 10.1101/gad.1658508  1
2008 Norris KL, Youle RJ. Cytomegalovirus proteins vMIA and m38.5 link mitochondrial morphogenesis to Bcl-2 family proteins. Journal of Virology. 82: 6232-43. PMID 18417572 DOI: 10.1128/JVI.02710-07  1
2008 Tanaka A, Youle RJ. A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis. Molecular Cell. 29: 409-10. PMID 18313377 DOI: 10.1016/j.molcel.2008.02.005  0.52
2008 Zanna C, Ghelli A, Porcelli AM, Karbowski M, Youle RJ, Schimpf S, Wissinger B, Pinti M, Cossarizza A, Vidoni S, Valentino ML, Rugolo M, Carelli V. OPA1 mutations associated with dominant optic atrophy impair oxidative phosphorylation and mitochondrial fusion. Brain : a Journal of Neurology. 131: 352-67. PMID 18222991 DOI: 10.1093/brain/awm335  1
2007 Neutzner A, Youle RJ, Karbowski M. Outer mitochondrial membrane protein degradation by the proteasome. Novartis Foundation Symposium. 287: 4-14; discussion 14-. PMID 18074628  1
2007 Karbowski M, Neutzner A, Youle RJ. The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division. The Journal of Cell Biology. 178: 71-84. PMID 17606867 DOI: 10.1083/jcb.200611064  1
2007 Goyal G, Fell B, Sarin A, Youle RJ, Sriram V. Role of mitochondrial remodeling in programmed cell death in Drosophila melanogaster. Developmental Cell. 12: 807-16. PMID 17488630 DOI: 10.1016/j.devcel.2007.02.002  1
2006 Karbowski M, Norris KL, Cleland MM, Jeong SY, Youle RJ. Role of Bax and Bak in mitochondrial morphogenesis. Nature. 443: 658-62. PMID 17035996 DOI: 10.1038/nature05111  1
2006 Barsoum MJ, Yuan H, Gerencser AA, Liot G, Kushnareva Y, Gräber S, Kovacs I, Lee WD, Waggoner J, Cui J, White AD, Bossy B, Martinou JC, Youle RJ, Lipton SA, et al. Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. The Embo Journal. 25: 3900-11. PMID 16874299 DOI: 10.1038/sj.emboj.7601253  1
2006 House SB, Rusnak M, Liu XH, Youle RJ, Gainer H. Bcl-xL and caspase inhibition increase the survival of rat oxytocin and vasopressin magnocellular neurons in organotypic culture. Experimental Neurology. 200: 267-71. PMID 16624298 DOI: 10.1016/j.expneurol.2006.02.009  1
2005 Takahashi Y, Karbowski M, Yamaguchi H, Kazi A, Wu J, Sebti SM, Youle RJ, Wang HG. Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis. Molecular and Cellular Biology. 25: 9369-82. PMID 16227588 DOI: 10.1128/MCB.25.21.9369-9382.2005  1
2005 Youle RJ, Karbowski M. Mitochondrial fission in apoptosis. Nature Reviews. Molecular Cell Biology. 6: 657-63. PMID 16025099 DOI: 10.1038/nrm1697  1
2005 Suzuki M, Neutzner A, Tjandra N, Youle RJ. Novel structure of the N terminus in yeast Fis1 correlates with a specialized function in mitochondrial fission. The Journal of Biological Chemistry. 280: 21444-52. PMID 15809300 DOI: 10.1074/jbc.M414092200  1
2005 Neutzner A, Youle RJ. Instability of the mitofusin Fzo1 regulates mitochondrial morphology during the mating response of the yeast Saccharomyces cerevisiae. The Journal of Biological Chemistry. 280: 18598-603. PMID 15760898 DOI: 10.1074/jbc.M500807200  1
2005 Nesic-Taylor O, Cittelly D, Ye Z, Xu GY, Unabia G, Lee JC, Svrakic NM, Liu XH, Youle RJ, Wood TG, McAdoo D, Westlund KN, Hulsebosch CE, Perez-Polo JR. Exogenous Bcl-xL fusion protein spares neurons after spinal cord injury. Journal of Neuroscience Research. 79: 628-37. PMID 15668909 DOI: 10.1002/jnr.20400  1
2004 Karbowski M, Jeong SY, Youle RJ. Endophilin B1 is required for the maintenance of mitochondrial morphology. The Journal of Cell Biology. 166: 1027-39. PMID 15452144 DOI: 10.1083/jcb.200407046  1
2004 Lee YJ, Jeong SY, Karbowski M, Smith CL, Youle RJ. Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis. Molecular Biology of the Cell. 15: 5001-11. PMID 15356267 DOI: 10.1091/mbc.E04-04-0294  1
2004 Karbowski M, Arnoult D, Chen H, Chan DC, Smith CL, Youle RJ. Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis. The Journal of Cell Biology. 164: 493-9. PMID 14769861 DOI: 10.1083/jcb.200309082  1
2004 Rostovtseva TK, Antonsson B, Suzuki M, Youle RJ, Colombini M, Bezrukov SM. Bid, but not Bax, regulates VDAC channels. The Journal of Biological Chemistry. 279: 13575-83. PMID 14729675 DOI: 10.1074/jbc.M310593200  1
2003 Suzuki M, Jeong SY, Karbowski M, Youle RJ, Tjandra N. The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundle. Journal of Molecular Biology. 334: 445-58. PMID 14623186 DOI: 10.1016/j.jmb.2003.09.064  1
2003 Arnoult D, Gaume B, Karbowski M, Sharpe JC, Cecconi F, Youle RJ. Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization. The Embo Journal. 22: 4385-99. PMID 12941691 DOI: 10.1093/emboj/cdg423  1
2003 Karbowski M, Youle RJ. Dynamics of mitochondrial morphology in healthy cells and during apoptosis. Cell Death and Differentiation. 10: 870-80. PMID 12867994 DOI: 10.1038/sj.cdd.4401260  1
2003 Putcha GV, Le S, Frank S, Besirli CG, Clark K, Chu B, Alix S, Youle RJ, LaMarche A, Maroney AC, Johnson EM. JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis. Neuron. 38: 899-914. PMID 12818176 DOI: 10.1016/S0896-6273(03)00355-6  1
2003 Arnoult D, Karbowski M, Youle RJ. Caspase inhibition prevents the mitochondrial release of apoptosis-inducing factor. Cell Death and Differentiation. 10: 845-9. PMID 12815467 DOI: 10.1038/sj.cdd.4401240  1
2003 Santetl A, Frank S, Gaume B, Herrler M, Youle RJ, Fuller MT. Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells Journal of Cell Science. 116: 2763-2774. PMID 12759376 DOI: 10.1242/jcs.00479  1
2003 Smaili SS, Hsu YT, Carvalho AC, Rosenstock TR, Sharpe JC, Youle RJ. Mitochondria, calcium and pro-apoptotic proteins as mediators in cell death signaling. Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas MéDicas E BiolóGicas / Sociedade Brasileira De BiofíSica ... [Et Al.]. 36: 183-90. PMID 12563519 DOI: 10.1590/S0100-879X2003000200004  1
2002 Karbowski M, Lee YJ, Gaume B, Jeong SY, Frank S, Nechushtan A, Santel A, Fuller M, Smith CL, Youle RJ. Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis Journal of Cell Biology. 159: 931-938. PMID 12499352 DOI: 10.1083/jcb.200209124  1
2002 De Giorgi F, Lartigue L, Bauer MKA, Schubert A, Grimm S, Hanson GT, Remington SJ, Youle RJ, Ichas F. The permeability transition pore signals apoptosis by directing Bax translocation and multimerization. The Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 607-609. PMID 11919169  1
2002 Saxena SK, Sirdeshmukh R, Ardelt W, Mikulski SM, Shogen K, Youle RJ. Entry into cells and selective degradation of tRNAs by a cytotoxic member of the RNase A family. The Journal of Biological Chemistry. 277: 15142-6. PMID 11839736 DOI: 10.1074/jbc.M108115200  1
2001 Liu XH, Collier RJ, Youle RJ. Inhibition of axotomy-induced neuronal apoptosis by extracellular delivery of a Bcl-XL fusion protein. The Journal of Biological Chemistry. 276: 46326-32. PMID 11574549 DOI: 10.1074/jbc.M108930200  1
2001 Smaili SS, Hsu YT, Sanders KM, Russell JT, Youle RJ. Bax translocation to mitochondria subsequent to a rapid loss of mitochondrial membrane potential. Cell Death and Differentiation. 8: 909-20. PMID 11526446 DOI: 10.1038/sj.cdd.4400889  1
2001 Richter BW, Mir SS, Eiben LJ, Lewis J, Reffey SB, Frattini A, Tian L, Frank S, Youle RJ, Nelson DL, Notarangelo LD, Vezzoni P, Fearnhead HO, Duckett CS. Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family. Molecular and Cellular Biology. 21: 4292-301. PMID 11390657 DOI: 10.1128/MCB.21.13.4292-4301.2001  1
2001 Leonidas DD, Boix E, Prill R, Suzuki M, Turton R, Minson K, Swaminathan GJ, Youle RJ, Acharya KR. Mapping the ribonucleolytic active site of eosinophil-derived neurotoxin (EDN). High resolution crystal structures of EDN complexes with adenylic nucleotide inhibitors. The Journal of Biological Chemistry. 276: 15009-17. PMID 11154698 DOI: 10.1074/jbc.M010585200  1
2000 Smaili SS, Hsu YT, Youle RJ, Russell JT. Mitochondria in Ca2+ signaling and apoptosis. Journal of Bioenergetics and Biomembranes. 32: 35-46. PMID 11768760 DOI: 10.1023/A:1005508311495  1
2000 Suzuki M, Youle RJ, Tjandra N. Structure of bax: Coregulation of dimer formation and intracellular localization Cell. 103: 645-654. PMID 11106734 DOI: 10.1016/S0092-8674(00)00167-7  1
2000 Ghatan S, Larner S, Kinoshita Y, Hetman M, Patel L, Xia Z, Youle RJ, Morrison RS. p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neurons. The Journal of Cell Biology. 150: 335-47. PMID 10908576 DOI: 10.1083/jcb.150.2.335  1
1999 Vasandani VM, Castelli JC, Hott JS, Saxena S, Mikulski SM, Youle RJ. Interferon enhances the activity of the anticancer ribonuclease, onconase. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 19: 447-54. PMID 10386856 DOI: 10.1089/107999099313884  1
1999 Basañez G, Nechushtan A, Drozhinin O, Chanturiya A, Choe E, Tutt S, Wood KA, Hsu Y, Zimmerberg J, Youle RJ. Bax, but not Bcl-xL, decreases the lifetime of planar phospholipid bilayer membranes at subnanomolar concentrations. Proceedings of the National Academy of Sciences of the United States of America. 96: 5492-7. PMID 10318911 DOI: 10.1073/pnas.96.10.5492  1
1998 Castelli J, Wood KA, Youle RJ. The 2-5A system in viral infection and apoptosis. Biomedicine & Pharmacotherapy = BioméDecine & PharmacothéRapie. 52: 386-90. PMID 9856285 DOI: 10.1016/S0753-3322(99)80006-7  1
1997 Castelli JC, Hassel BA, Wood KA, Li XL, Amemiya K, Dalakas MC, Torrence PF, Youle RJ. A study of the interferon antiviral mechanism: apoptosis activation by the 2-5A system. The Journal of Experimental Medicine. 186: 967-72. PMID 9294150 DOI: 10.1084/jem.186.6.967  1
1996 Saxena SK, Gravell M, Wu YN, Mikulski SM, Shogen K, Ardelt W, Youle RJ. Inhibition of HIV-1 production and selective degradation of viral RNA by an amphibian ribonuclease. The Journal of Biological Chemistry. 271: 20783-8. PMID 8702832 DOI: 10.1074/jbc.271.34.20783  1
1995 Wu Y, Saxena SK, Ardelt W, Gadina M, Mikulski SM, De Lorenzo C, D'Alessio G, Youle RJ. A study of the intracellular routing of cytotoxic ribonucleases. The Journal of Biological Chemistry. 270: 17476-81. PMID 7542240 DOI: 10.1074/jbc.270.29.17476  1
1994 Youle RJ, Wu YN, Mikulski SM, Shogen K, Hamilton RS, Newton D, D'Alessio G, Gravell M. RNase inhibition of human immunodeficiency virus infection of H9 cells. Proceedings of the National Academy of Sciences of the United States of America. 91: 6012-6. PMID 8016107 DOI: 10.1073/pnas.91.13.6012  1
1994 Lin JJ, Newton DL, Mikulski SM, Kung HF, Youle RJ, Rybak SM. Characterization of the mechanism of cellular and cell free protein synthesis inhibition by an anti-tumor ribonuclease. Biochemical and Biophysical Research Communications. 204: 156-62. PMID 7945354 DOI: 10.1006/bbrc.1994.2439  1
1994 Wood KA, Youle RJ. Apoptosis and free radicals. Annals of the New York Academy of Sciences. 738: 400-7. PMID 7832448 DOI: 10.1111/j.1749-6632.1994.tb21829.x  1
1993 Wood KA, Dipasquale B, Youle RJ. In situ labeling of granule cells for apoptosis-associated DNA fragmentation reveals different mechanisms of cell loss in developing cerebellum. Neuron. 11: 621-32. PMID 8398151 DOI: 10.1016/0896-6273(93)90074-2  1
1990 Riedel CJ, Muraszko KM, Youle RJ. Diphtheria toxin mutant selectively kills cerebellar Purkinje neurons Proceedings of the National Academy of Sciences of the United States of America. 87: 5051-5055. PMID 2367523 DOI: 10.1073/pnas.87.13.5051  1
1985 Kersey JH, Vallera D, Ramsay N, Filipovich A, Youle R, Neville D, Stong R, LeBien T. Monoclonal antibodies and immunotoxins in bone marrow transplantation: purging marrow of ALL or GVHD cells with preservation of stem cells. Haematology and Blood Transfusion. 29: 34-8. PMID 3896970 DOI: 10.1007/978-3-642-70385-0_6  1
1983 Vallera DA, Ash RC, Zanjani ED, Kersey JH, Lebien TW, Beverley PCL, Neville DM, Youle RJ. Anti-T-Cell reagents for human bone marrow transplantation: Ricin linked to three monoclonal antibodies Science. 222: 512-515. PMID 6353579 DOI: 10.1126/science.6353579  1
1983 Vallera DA, Youle RJ, Neville DM, Soderling CCB, Kersey JH. Monoclonal antibody toxin conjugates for experimental graft-versus-host disease prophylaxis: Reagents selectively reactive with t cells and not murine stem cells Transplantation. 36: 73-80. PMID 6346616 DOI: 10.1097/00007890-198307000-00015  1
1982 Vallera DA, Youle RJ, Neville DM, Kersey JH. Bone marrow transplantation across major histocompatibility barriers. V. Protection of mice from lethal graft-vs.-host disease by pretreatment of donor cells with monoclonal anti-Thy-1.2 coupled to the toxin ricin Journal of Experimental Medicine. 155: 949-954. PMID 6120991 DOI: 10.1084/jem.155.3.949  1
1981 Youle RJ, Murray GJ, Neville DM. Studies on the galactose-binding site of ricin and the hybrid toxin man6P-ricin Cell. 23: 551-559. PMID 7471212 DOI: 10.1016/0092-8674(81)90151-3  1
1980 Neville DM, Murray GJ, Youle RJ. Directed entry of hybrid proteins into cells via alternative receptors Biochemical Society Transactions. 8: 692-693. PMID 7461253 DOI: 10.1042/bst0080692  1
1979 Youle RJ, Murray GJ, Neville DM. Ricin linked to monophosphopentamannose binds to fibroblast lysosomal hydrolase receptors, resulting in a cell-type-specific toxin Proceedings of the National Academy of Sciences of the United States of America. 76: 5559-5562. PMID 293662 DOI: 10.1073/pnas.76.11.5559  1
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