Nathaniel W. Snyder, Ph.D. - Publications

Affiliations: 
2013 Pharmacology University of Pennsylvania, Philadelphia, PA, United States 
Area:
Biochemistry, Pharmacy, Analytical Chemistry, Pharmacology

48 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Kuskovsky R, Buj R, Xu P, Hofbauer S, Doan MT, Jiang H, Bostwick A, Mesaros C, Aird KM, Snyder NW. Simultaneous isotope dilution quantification and metabolic tracing of deoxyribonucleotides by liquid chromatography high resolution mass spectrometry. Analytical Biochemistry. 568: 65-72. PMID 30605633 DOI: 10.1016/j.ab.2018.12.023  0.96
2018 O'Neill K, Alexander J, Azuma R, Xiao R, Snyder NW, Mesaros CA, Blair IA, Pinney SE. Gestational Diabetes Alters the Metabolomic Profile in 2nd Trimester Amniotic Fluid in a Sex-Specific Manner. International Journal of Molecular Sciences. 19. PMID 30201937 DOI: 10.3390/ijms19092696  0.96
2018 Xin F, Fischer E, Krapp C, Krizman EN, Lan Y, Mesaros C, Snyder NW, Bansal A, Robinson MB, Simmons RA, Bartolomei MS. Mice exposed to bisphenol A exhibit depressive-like behavior with neurotransmitter and neuroactive steroid dysfunction. Hormones and Behavior. PMID 29763587 DOI: 10.1016/j.yhbeh.2018.05.010  0.96
2018 Trefely S, Mesaros C, Xu P, Doan MT, Jiang H, Altinok O, Orynbayeva Z, Snyder NW. Artefactual formation of pyruvate from in-source conversion of lactate. Rapid Communications in Mass Spectrometry : Rcm. PMID 29740888 DOI: 10.1002/rcm.8159  0.96
2018 Sinclair WR, Shrimp JH, Zengeya TT, Kulkarni RA, Garlick JM, Luecke H, Worth AJ, Blair IA, Snyder NW, Meier JL. Bioorthogonal pro-metabolites for profiling short chain fatty acylation. Chemical Science. 9: 1236-1241. PMID 29675169 DOI: 10.1039/c7sc00247e  0.96
2018 O'Connor RS, Guo L, Ghassemi S, Snyder NW, Worth AJ, Weng L, Kam Y, Philipson B, Trefely S, Nunez-Cruz S, Blair IA, June CH, Milone MC. The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations. Scientific Reports. 8: 6289. PMID 29674640 DOI: 10.1038/s41598-018-24676-6  0.96
2018 Romero F, Hong X, Shah D, Kallen CB, Rosas I, Guo Z, Schriner D, Barta J, Shaghaghi H, Hoek JB, Mesaros C, Choi AM, Snyder NW, Summer R. Lipid Synthesis is Required to Resolve ER Stress and Limit Fibrotic Responses in the Lung. American Journal of Respiratory Cell and Molecular Biology. PMID 29465261 DOI: 10.1165/rcmb.2017-0340OC  0.96
2018 Wang Q, Guo L, Strawser CJ, Hauser LA, Hwang WT, Snyder NW, Lynch DR, Mesaros C, Blair IA. Low apolipoprotein A-I levels in Friedreich's ataxia and in frataxin-deficient cells: Implications for therapy. Plos One. 13: e0192779. PMID 29447225 DOI: 10.1371/journal.pone.0192779  0.96
2017 Shrimp JH, Garlick J, Tezil T, Sorum AW, Worth AJ, Blair IA, Verdin E, Snyder NW, Meier JL. Defining metabolic and non-metabolic regulation of histone acetylation by a NSAID chemotype. Molecular Pharmaceutics. PMID 29240439 DOI: 10.1021/acs.molpharmaceut.7b00943  0.96
2017 Frederick DW, Trefely S, Buas A, Goodspeed J, Singh J, Mesaros C, Baur JA, Snyder NW. Stable isotope labeling by essential nutrients in cell culture (SILEC) for accurate measurement of nicotinamide adenine dinucleotide metabolism. The Analyst. PMID 29072717 DOI: 10.1039/c7an01378g  0.96
2017 Sims C, Salliant N, Worth AJ, Parry R, Mesaros C, Blair IA, Snyder NW. Metabolic tracing analysis reveals substrate-specific metabolic deficits in platelet storage lesion. Transfusion. PMID 28836286 DOI: 10.1111/trf.14292  0.96
2017 Else T, Marcondes Lerario A, Everett J, Haymon L, Wham D, Mullane M, Wilson TL, Rainville I, Rana H, Worth AJ, Snyder NW, Blair IA, McKay R, Kilbridge K, Hammer GD, et al. Adrenocortical carcinoma and succinate dehydrogenase gene mutations. European Journal of Endocrinology. PMID 28819017 DOI: 10.1530/EJE-17-0358  0.96
2017 Xu R, Mesaros C, Weng L, Snyder NW, Vachani A, Blair IA, Hwang WT. Comparison of statistical methods for detection of serum lipid biomarkers for mesothelioma and asbestos exposure. Biomarkers in Medicine. PMID 28534416 DOI: 10.2217/bmm-2017-0087  0.96
2017 Mesaros C, Arroyo AD, Blair IA, Snyder NW. Coenzyme A thioester formation of 11- and 15-oxo-eicosatetraenoic acid. Prostaglandins & Other Lipid Mediators. PMID 28238887 DOI: 10.1016/j.prostaglandins.2017.02.004  0.96
2017 Kulkarni RA, Worth AJ, Zengeya TT, Shrimp JH, Garlick JM, Roberts AM, Montgomery DC, Sourbier C, Gibbs BK, Mesaros C, Tsai YC, Das S, Chan KC, Zhou M, Andresson T, ... ... Snyder NW, et al. Discovering Targets of Non-enzymatic Acylation by Thioester Reactivity Profiling. Cell Chemical Biology. PMID 28163016 DOI: 10.1016/j.chembiol.2017.01.002  0.96
2017 Carrer A, Parris JL, Trefely S, Henry RA, Montgomery DC, Torres A, Viola JM, Kuo YM, Blair IA, Meier JL, Andrews AJ, Snyder NW, Wellen KE. Impact of High Fat Diet on Tissue Acyl-CoA and Histone Acetylation Levels. The Journal of Biological Chemistry. PMID 28077572 DOI: 10.1074/jbc.M116.750620  0.96
2016 Kawalekar OU, O' Connor RS, Fraietta JA, Guo L, McGettigan SE, Posey AD, Patel PR, Guedan S, Scholler J, Keith B, Snyder NW, Blair IA, Milone MC, June CH. Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells. Immunity. 44: 712. PMID 28843072 DOI: 10.1016/j.immuni.2016.02.023  0.96
2016 Pinney SE, Mesaros CA, Snyder NW, Busch CM, Xiao R, Aijaz S, Ijaz N, Blair IA, Manson JM. Second trimester amniotic fluid bisphenol a concentration is associated with decreased birth weight in term infants. Reproductive Toxicology (Elmsford, N.Y.). PMID 27829162 DOI: 10.1016/j.reprotox.2016.11.007  0.96
2016 Zhao S, Torres A, Henry RA, Trefely S, Wallace M, Lee JV, Carrer A, Sengupta A, Campbell SL, Kuo YM, Frey AJ, Meurs N, Viola JM, Blair IA, Weljie AM, ... ... Snyder NW, et al. ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic Switch. Cell Reports. 17: 1037-1052. PMID 27760311 DOI: 10.1016/j.celrep.2016.09.069  0.96
2016 Frey AJ, Wang Q, Busch C, Feldman D, Bottalico L, Mesaros CA, Blair IA, Vachani A, Snyder NW. Validation of highly sensitive simultaneous targeted and untargeted analysis of keto-steroids by Girard P derivatization and stable isotope dilution-liquid chromatography-high resolution mass spectrometry. Steroids. PMID 27743906 DOI: 10.1016/j.steroids.2016.10.003  0.96
2016 Guo L, Worth AJ, Mesaros C, Snyder NW, Glickson JD, Blair IA. Diisopropylethylamine/hexafluoroisopropanol-mediated ion-pairing ultra-high-performance liquid chromatography/mass spectrometry for phosphate and carboxylate metabolite analysis: utility for studying cellular metabolism. Rapid Communications in Mass Spectrometry : Rcm. 30: 1835-45. PMID 27476658 DOI: 10.1002/rcm.7667  0.96
2016 Saha A, O'Connor RS, Thangavelu G, Lovitch SB, Dandamudi DB, Wilson CB, Vincent BG, Tkachev V, Pawlicki JM, Furlan SN, Kean LS, Aoyama K, Taylor PA, Panoskaltsis-Mortari A, Foncea R, ... ... Snyder NW, et al. Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality. The Journal of Clinical Investigation. PMID 27294527 DOI: 10.1172/JCI85796  0.96
2016 Worth AJ, Marchione DM, Parry RC, Wang Q, Gillespie KP, Saillant NN, Sims C, Mesaros C, Snyder NW, Blair IA. LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism. Journal of Visualized Experiments : Jove. PMID 27077278 DOI: 10.3791/53941  0.96
2016 Daurio NA, Tuttle SW, Worth AJ, Song EY, Davis JM, Snyder NW, Blair IA, Koumenis C. AMPK activation and metabolic reprogramming by tamoxifen through estrogen receptor-independent mechanisms suggests new uses for this therapeutic modality in cancer treatment. Cancer Research. PMID 27020861 DOI: 10.1158/0008-5472.CAN-15-2197  0.96
2016 Frey AJ, Feldman DR, Trefely S, Worth AJ, Basu SS, Snyder NW. LC-quadrupole/Orbitrap high-resolution mass spectrometry enables stable isotope-resolved simultaneous quantification and (13)C-isotopic labeling of acyl-coenzyme A thioesters. Analytical and Bioanalytical Chemistry. PMID 26968563 DOI: 10.1007/s00216-016-9448-5  0.96
2016 Covarrubias AJ, Aksoylar HI, Yu J, Snyder NW, Worth AJ, Iyer SS, Wang J, Ben-Sahra I, Byles V, Polynne-Stapornkul T, Espinosa EC, Lamming D, Manning BD, Zhang Y, Blair IA, et al. Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation. Elife. 5. PMID 26894960 DOI: 10.7554/eLife.11612  0.96
2016 Kawalekar OU, O'Connor RS, Fraietta JA, Guo L, McGettigan SE, Posey AD, Patel PR, Guedan S, Scholler J, Keith B, Snyder N, Blair I, Milone MC, June CH. Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells. Immunity. 44: 380-390. PMID 26885860 DOI: 10.1016/j.immuni.2016.01.021  0.96
2016 Bedi KC, Snyder NW, Brandimarto J, Aziz M, Mesaros C, Worth A, Wang L, Javaheri A, Blair IA, Margulies K, Rame JE. Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure. Circulation. PMID 26819374 DOI: 10.1161/CIRCULATIONAHA.115.017545  0.96
2016 Kawalekar OU, O' Connor RS, Fraietta JA, Guo L, McGettigan SE, Posey AD, Patel PR, Guedan S, Scholler J, Keith B, Snyder NW, Blair IA, Milone MC, June CH. Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells [Immunity 44, 380-390, (2016)] Immunity. 44: 712. DOI: 10.1016/j.immuni.2016.02.023  0.96
2015 Wang Q, Zhang S, Guo L, Busch CM, Jian W, Weng N, Snyder NW, Rangiah K, Mesaros C, Blair IA. Serum apolipoprotein A-1 quantification by LC-MS with a SILAC internal standard reveals reduced levels in smokers. Bioanalysis. PMID 26394123 DOI: 10.4155/bio.15.195  0.96
2015 Snyder NW, Mesaros C, Blair IA. Translational metabolomics in cancer research. Biomarkers in Medicine. 9: 821-34. PMID 26329905 DOI: 10.2217/bmm.15.52  0.96
2015 Worth AJ, Basu SS, Deutsch EC, Hwang WT, Snyder NW, Lynch DR, Blair IA. Stable isotopes and LC-MS for monitoring metabolic disturbances in Friedreich's ataxia platelets. Bioanalysis. 7: 1843-55. PMID 26295986 DOI: 10.4155/bio.15.118  0.96
2015 Mesaros C, Worth AJ, Snyder NW, Christofidou-Solomidou M, Vachani A, Albelda SM, Blair IA. Bioanalytical techniques for detecting biomarkers of response to human asbestos exposure. Bioanalysis. 7: 1157-73. PMID 26039812 DOI: 10.4155/bio.15.53  0.96
2015 Cossette C, Gravel S, Reddy CN, Gore V, Chourey S, Ye Q, Snyder NW, Mesaros CA, Blair IA, Lavoie JP, Reinero CR, Rokach J, Powell WS. Biosynthesis and actions of 5-oxoeicosatetraenoic acid (5-oxo-ETE) on feline granulocytes. Biochemical Pharmacology. 96: 247-55. PMID 26032638 DOI: 10.1016/j.bcp.2015.05.009  0.96
2015 Aird KM, Worth AJ, Snyder NW, Lee JV, Sivanand S, Liu Q, Blair IA, Wellen KE, Zhang R. ATM couples replication stress and metabolic reprogramming during cellular senescence. Cell Reports. 11: 893-901. PMID 25937285 DOI: 10.1016/j.celrep.2015.04.014  0.96
2015 Worth AJ, Gillespie KP, Mesaros C, Guo L, Basu SS, Snyder NW, Blair IA. Rotenone Stereospecifically Increases (S)-2-Hydroxyglutarate in SH-SY5Y Neuronal Cells. Chemical Research in Toxicology. 28: 948-54. PMID 25800467 DOI: 10.1021/tx500535c  0.96
2015 Wang Q, Rangiah K, Mesaros C, Snyder NW, Vachani A, Song H, Blair IA. Ultrasensitive quantification of serum estrogens in postmenopausal women and older men by liquid chromatography-tandem mass spectrometry. Steroids. 96: 140-52. PMID 25637677 DOI: 10.1016/j.steroids.2015.01.014  0.96
2015 Snyder NW, Tombline G, Worth AJ, Parry RC, Silvers JA, Gillespie KP, Basu SS, Millen J, Goldfarb DS, Blair IA. Production of stable isotope-labeled acyl-coenzyme A thioesters by yeast stable isotope labeling by essential nutrients in cell culture. Analytical Biochemistry. 474: 59-65. PMID 25572876 DOI: 10.1016/j.ab.2014.12.014  0.96
2015 Snyder NW, Golin-Bisello F, Gao Y, Blair IA, Freeman BA, Wendell SG. 15-Oxoeicosatetraenoic acid is a 15-hydroxyprostaglandin dehydrogenase-derived electrophilic mediator of inflammatory signaling pathways. Chemico-Biological Interactions. 234: 144-53. PMID 25450232 DOI: 10.1016/j.cbi.2014.10.029  0.96
2015 Snyder NW, Basu SS, Worth AJ, Mesaros C, Blair IA. Metabolism of propionic acid to a novel acyl-coenzyme A thioester by mammalian cell lines and platelets. Journal of Lipid Research. 56: 142-50. PMID 25424005 DOI: 10.1194/jlr.M055384  0.96
2015 Mesaros C, Worth AJ, Snyder NW, Christofidou-Solomidou M, Vachani A, Albelda SM, Blair IA. Bioanalytical techniques for detecting biomarkers of response to human asbestos exposure Bioanalysis. 7: 1157-1173. DOI: 10.4155/bio.15.53  0.96
2015 Aird KM, Worth AJ, Snyder NW, Lee JV, Sivanand S, Liu Q, Blair IA, Wellen KE, Zhang R. ATM Couples Replication Stress and Metabolic Reprogramming during Cellular Senescence Cell Reports. 11: 893-901. DOI: 10.1016/j.celrep.2015.04.014  0.96
2014 Snyder NW, Basu SS, Zhou Z, Worth AJ, Blair IA. Stable isotope dilution liquid chromatography/mass spectrometry analysis of cellular and tissue medium- and long-chain acyl-coenzyme A thioesters. Rapid Communications in Mass Spectrometry : Rcm. 28: 1840-8. PMID 25559454 DOI: 10.1002/rcm.6958  0.96
2014 Worth AJ, Basu SS, Snyder NW, Mesaros C, Blair IA. Inhibition of neuronal cell mitochondrial complex I with rotenone increases lipid β-oxidation, supporting acetyl-coenzyme A levels. The Journal of Biological Chemistry. 289: 26895-903. PMID 25122772 DOI: 10.1074/jbc.M114.591354  0.96
2014 Lee JV, Carrer A, Shah S, Snyder NW, Wei S, Venneti S, Worth AJ, Yuan ZF, Lim HW, Liu S, Jackson E, Aiello NM, Haas NB, Rebbeck TR, Judkins A, et al. Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation. Cell Metabolism. 20: 306-19. PMID 24998913 DOI: 10.1016/j.cmet.2014.06.004  0.96
2013 Snyder NW, Revello SD, Liu X, Zhang S, Blair IA. Cellular uptake and antiproliferative effects of 11-oxo-eicosatetraenoic acid. Journal of Lipid Research. 54: 3070-7. PMID 23945567 DOI: 10.1194/jlr.M040741  0.96
2013 Snyder NW, Khezam M, Mesaros CA, Worth A, Blair IA. Untargeted metabolomics from biological sources using ultraperformance liquid chromatography-high resolution mass spectrometry (UPLC-HRMS). Journal of Visualized Experiments : Jove. e50433. PMID 23711563 DOI: 10.3791/50433  0.96
2011 Liu X, Zhang S, Arora JS, Snyder NW, Shah SJ, Blair IA. 11-Oxoeicosatetraenoic acid is a cyclooxygenase-2/15-hydroxyprostaglandin dehydrogenase-derived antiproliferative eicosanoid. Chemical Research in Toxicology. 24: 2227-36. PMID 21916491 DOI: 10.1021/tx200336f  0.96
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