Paul M. Grandgenett, Ph.D. - Publications

Affiliations: 
2005 University of Iowa, Iowa City, IA 
Area:
Genetics

38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Markov SD, Caffrey TC, O' Connell KA, Grunkemeyer JA, Shin S, Hanson R, Patil PP, Shukla SK, Gonzalez D, Crawford AJ, Vance KE, Huang Y, Eberle KC, Radhakrishnan P, Grandgenett PM, et al. IgE-based therapeutic combination enhances anti-tumor response in preclinical models of pancreatic cancer. Molecular Cancer Therapeutics. PMID 34625505 DOI: 10.1158/1535-7163.MCT-21-0368  1
2021 Law HC, Clement EJ, Grandgenett PM, Hollingsworth MA, Woods NT. The Proteomic Landscape of Pancreatic Ductal Adenocarcinoma Liver Metastases Identifies Molecular Subtypes and Associations with Clinical Response-Response. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 27: 4127. PMID 34261772 DOI: 10.1158/1078-0432.CCR-21-1220  1
2021 Saxena S, Prajapati DR, Goel P, Tomar B, Hayashi Y, Atri P, Rachagani S, Grandgenett PM, Hollingsworth MA, Batra SK, Singh RK. Plexin-B3 Regulates Cellular Motility, Invasiveness, and Metastasis in Pancreatic Cancer. Cancers. 13. PMID 33669221 DOI: 10.3390/cancers13040818  1
2020 Thomas D, Sagar S, Liu X, Lee HR, Grunkemeyer JA, Grandgenett PM, Caffrey T, O'Connell KA, Swanson B, Marcos-Silva L, Steentoft C, Wandall HH, Maurer HC, Peng XL, Yeh JJ, et al. Isoforms of MUC16 Activate Oncogenic Signaling Through EGF Receptors to Enhance the Progression of Pancreatic Cancer. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 33359791 DOI: 10.1016/j.ymthe.2020.12.029  1
2020 Nimmakayala RK, Leon F, Rachagani S, Rauth S, Nallasamy P, Marimuthu S, Shailendra GK, Chhonker YS, Chugh S, Chirravuri R, Gupta R, Mallya K, Prajapati DR, Lele SM, C Caffrey T, ... ... Grandgenett PM, et al. Metabolic programming of distinct cancer stem cells promotes metastasis of pancreatic ductal adenocarcinoma. Oncogene. PMID 33110235 DOI: 10.1038/s41388-020-01518-2  1
2020 Young ED, Manley SJ, Beadnell TC, Shearin AE, Sasaki K, Zimmerman R, Kauffman E, Vivian CJ, Parasuram A, Iwakuma T, Grandgenett PM, Hollingsworth MA, O'Neil M, Welch DR. Suppression of pancreatic cancer liver metastasis by secretion-deficient ITIH5. British Journal of Cancer. PMID 33024269 DOI: 10.1038/s41416-020-01093-z  1
2020 Lenkiewicz E, Malasi S, Hogenson TL, Flores LF, Barham W, Phillips WJ, Roesler AS, Chambers KR, Rajbhandari N, Hayashi A, Grandgenett PM, Hollingsworth MA, Cridebring D, Xiong Y, Lee JH, et al. Genomic and Epigenomic Landscaping Defines New Therapeutic Targets for Adenosquamous Carcinoma of the Pancreas. Cancer Research. PMID 32928922 DOI: 10.1158/0008-5472.Can-20-0078  1
2020 Hoshino A, Kim HS, Bojmar L, Gyan KE, Cioffi M, Hernandez J, Zambirinis CP, Rodrigues G, Molina H, Heissel S, Mark MT, Steiner L, Benito-Martin A, Lucotti S, Di Giannatale A, ... ... Grandgenett PM, et al. Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. Cell. PMID 32795414 DOI: 10.1016/J.Cell.2020.07.009  1
2020 Dasgupta A, Shukla SK, Vernucci E, King RJ, Abrego J, Mulder SE, Mullen NJ, Graves G, Buettner K, Thakur R, Murthy D, Attri KS, Wang D, Chaika NV, Pacheco CG, ... ... Grandgenett PM, et al. SIRT1-NOX4 signaling axis regulates cancer cachexia. The Journal of Experimental Medicine. 217. PMID 32441762 DOI: 10.1084/Jem.20190745  1
2020 Shukla SK, Markov SD, Attri KS, Vernucci E, King RJ, Dasgupta A, Grandgenett PM, Hollingsworth MA, Singh PK, Yu F, Mehla K. Macrophages potentiate STAT3 signaling in skeletal muscles and regulate pancreatic cancer cachexia. Cancer Letters. PMID 32344015 DOI: 10.1016/J.Canlet.2020.04.017  1
2019 Shakri AR, Zhong TJ, Ma W, Coker C, Kim S, Calluori S, Scholze H, Szabolcs M, Caffrey T, Grandgenett PM, Hollingsworth MA, Tanji K, Kluger MD, Miller G, Biswas AK, et al. Upregulation of ZIP14 and Altered Zinc Homeostasis in Muscles in Pancreatic Cancer Cachexia. Cancers. 12. PMID 31861290 DOI: 10.3390/Cancers12010003  1
2019 Law HC, Lagundžin D, Clement EJ, Qiao F, Wagner ZS, Krieger KL, Costanzo-Garvey D, Caffrey TC, Grem JL, DiMaio DJ, Grandgenett PM, Cook LM, Fisher KW, Yu F, Hollingsworth MA, et al. The Proteomic Landscape of Pancreatic Ductal Adenocarcinoma Liver Metastases Identifies Molecular Subtypes and Associations with Clinical Response. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31848187 DOI: 10.1158/1078-0432.Ccr-19-1496  1
2019 Thomas D, Sagar S, Caffrey T, Grandgenett PM, Radhakrishnan P. Truncated O-glycans promote epithelial-to-mesenchymal transition and stemness properties of pancreatic cancer cells. Journal of Cellular and Molecular Medicine. PMID 31389667 DOI: 10.1111/jcmm.14572  1
2019 Leiphrakpam PD, Patil PP, Remmers N, Swanson B, Grandgenett PM, Qiu F, Yu F, Radhakrishnan P. Role of keratan sulfate expression in human pancreatic cancer malignancy. Scientific Reports. 9: 9665. PMID 31273306 DOI: 10.1038/S41598-019-46046-6  1
2019 Shi Y, Gao W, Lytle NK, Huang P, Yuan X, Dann AM, Ridinger-Saison M, DelGiorno KE, Antal CE, Liang G, Atkins AR, Erikson G, Sun H, Meisenhelder J, Terenziani E, ... ... Grandgenett PM, et al. Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. Nature. PMID 30996350 DOI: 10.1038/S41586-019-1130-6  1
2019 Jahan R, Ganguly K, Smith LM, Atri P, Carmicheal J, Sheinin Y, Rachagani S, Natarajan G, Brand RE, Macha MA, Grandgenett PM, Kaur S, Batra SK. Trefoil factor(s) and CA19.9: A promising panel for early detection of pancreatic cancer. Ebiomedicine. PMID 30956167 DOI: 10.1016/J.Ebiom.2019.03.056  1
2018 Wang G, Biswas AK, Ma W, Kandpal M, Coker C, Grandgenett PM, Hollingsworth MA, Jain R, Tanji K, Lόpez-Pintado S, Borczuk A, Hebert D, Jenkitkasemwong S, Hojyo S, Davuluri RV, et al. Metastatic cancers promote cachexia through ZIP14 upregulation in skeletal muscle. Nature Medicine. 24: 770-781. PMID 29875463 DOI: 10.1038/S41591-018-0054-2  1
2018 Tiriac H, Belleau P, Engle DD, Plenker D, Deschênes A, Somerville T, Froeling FEM, Burkhart RA, Denroche RE, Jang GH, Miyabayashi K, Young CM, Patel H, Ma M, LaComb JF, ... ... Grandgenett PM, et al. Organoid profiling identifies common responders to chemotherapy in pancreatic cancer. Cancer Discovery. PMID 29853643 DOI: 10.1158/2159-8290.Cd-18-0349  1
2017 Shukla SK, Purohit V, Mehla K, Gunda V, Chaika NV, Vernucci E, King RJ, Abrego J, Goode GD, Dasgupta A, Illies AL, Gebregiworgis T, Dai B, Augustine JJ, Murthy D, ... ... Grandgenett PM, et al. MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer. Cancer Cell. 32: 392. PMID 28898700 DOI: 10.1016/J.Ccell.2017.08.008  1
2017 Roe JS, Hwang CI, Somerville TDD, Milazzo JP, Lee EJ, Da Silva B, Maiorino L, Tiriac H, Young CM, Miyabayashi K, Filippini D, Creighton B, Burkhart RA, Buscaglia JM, Kim EJ, ... ... Grandgenett PM, et al. Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis. Cell. PMID 28757253 DOI: 10.1016/J.Cell.2017.07.007  1
2017 Shukla SK, Purohit V, Mehla K, Gunda V, Chaika NV, Vernucci E, King RJ, Abrego J, Goode GD, Dasgupta A, Illies AL, Gebregiworgis T, Dai B, Augustine JJ, Murthy D, ... ... Grandgenett PM, et al. MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer. Cancer Cell. 32: 71-87.e7. PMID 28697344 DOI: 10.1016/J.Ccell.2017.06.004  1
2016 Clausen TM, Pereira MA, Al Nakouzi N, Oo HZ, Agerbæk MO, Lee S, Orum-Madsen MS, Kristensen AR, El-Naggar A, Grandgenett PM, Grem JL, Hollingsworth MA, Holst PJ, Theander TG, Sorensen PH, et al. Oncofetal Chondroitin Sulfate Glycosaminoglycans are Key Players in Integrin Signaling and Tumor Cell Motility. Molecular Cancer Research : McR. PMID 27655130 DOI: 10.1158/1541-7786.Mcr-16-0103  1
2016 Sousa AM, Grandgenett PM, David L, Almeida R, Hollingsworth MA, Santos-Silva F. Reflections on MUC1 glycoprotein: the hidden potential of isoforms in carcinogenesis. Apmis : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. PMID 27538373 DOI: 10.1111/Apm.12587  1
2016 Fox RG, Lytle NK, Jaquish DV, Park FD, Ito T, Bajaj J, Koechlein CS, Zimdahl B, Yano M, Kopp JL, Kritzik M, Sicklick JK, Sander M, Grandgenett PM, Hollingsworth MA, et al. Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma. Nature. PMID 27281208 DOI: 10.1038/Nature17988  1
2016 Hanson RL, Brown RB, Steele MM, Grandgenett PM, Grunkemeyer JA, Hollingsworth MA. Identification of FRA-1 as a novel player in pancreatic cancer in cooperation with a MUC1: ERK signaling axis. Oncotarget. PMID 27220889 DOI: 10.18632/Oncotarget.9557  1
2015 Hoshino A, Costa-Silva B, Shen TL, Rodrigues G, Hashimoto A, Tesic Mark M, Molina H, Kohsaka S, Di Giannatale A, Ceder S, Singh S, Williams C, Soplop N, Uryu K, Pharmer L, ... ... Grandgenett PM, et al. Tumour exosome integrins determine organotropic metastasis. Nature. PMID 26524530 DOI: 10.1038/Nature15756  1
2015 Costa-Silva B, Aiello NM, Ocean AJ, Singh S, Zhang H, Thakur BK, Becker A, Hoshino A, Mark MT, Molina H, Xiang J, Zhang T, Theilen TM, García-Santos G, Williams C, ... ... Grandgenett PM, et al. Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver. Nature Cell Biology. 17: 816-26. PMID 25985394 DOI: 10.1038/Ncb3169  1
2013 Radhakrishnan P, Mohr AM, Grandgenett PM, Steele MM, Batra SK, Hollingsworth MA. MicroRNA-200c modulates the expression of MUC4 and MUC16 by directly targeting their coding sequences in human pancreatic cancer. Plos One. 8: e73356. PMID 24204560 DOI: 10.1371/Journal.Pone.0073356  1
2013 Radhakrishnan P, Grandgenett PM, Mohr AM, Bunt SK, Yu F, Chowdhury S, Hollingsworth MA. Expression of core 3 synthase in human pancreatic cancer cells suppresses tumor growth and metastasis. International Journal of Cancer. Journal International Du Cancer. 133: 2824-33. PMID 23754791 DOI: 10.1002/Ijc.28322  1
2013 Radhakrishnan P, Bryant VC, Blowers EC, Rajule RN, Gautam N, Anwar MM, Mohr AM, Grandgenett PM, Bunt SK, Arnst JL, Lele SM, Alnouti Y, Hollingsworth MA, Natarajan A. Targeting the NF-κB and mTOR pathways with a quinoxaline urea analog that inhibits IKKβ for pancreas cancer therapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 2025-35. PMID 23444213 DOI: 10.1158/1078-0432.Ccr-12-2909  1
2013 Bunt SK, Mohr AM, Bailey JM, Grandgenett PM, Hollingsworth MA. Rosiglitazone and Gemcitabine in combination reduces immune suppression and modulates T cell populations in pancreatic cancer. Cancer Immunology, Immunotherapy : Cii. 62: 225-36. PMID 22864396 DOI: 10.1007/S00262-012-1324-3  1
2011 Eggers JP, Grandgenett PM, Collisson EC, Lewallen ME, Tremayne J, Singh PK, Swanson BJ, Andersen JM, Caffrey TC, High RR, Ouellette M, Hollingsworth MA. Cyclin-dependent kinase 5 is amplified and overexpressed in pancreatic cancer and activated by mutant K-Ras. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 6140-50. PMID 21825040 DOI: 10.1158/1078-0432.Ccr-10-2288  1
2010 Behrens ME, Grandgenett PM, Bailey JM, Singh PK, Yi CH, Yu F, Hollingsworth MA. The reactive tumor microenvironment: MUC1 signaling directly reprograms transcription of CTGF. Oncogene. 29: 5667-77. PMID 20697347 DOI: 10.1038/Onc.2010.327  1
2008 Shintani Y, Fukumoto Y, Chaika N, Grandgenett PM, Hollingsworth MA, Wheelock MJ, Johnson KR. ADH-1 suppresses N-cadherin-dependent pancreatic cancer progression. International Journal of Cancer. Journal International Du Cancer. 122: 71-7. PMID 17721921 DOI: 10.1002/Ijc.23027  1
2007 Grandgenett PM, Otsu K, Wilson HR, Wilson ME, Donelson JE. A function for a specific zinc metalloprotease of African trypanosomes. Plos Pathogens. 3: 1432-45. PMID 17953481 DOI: 10.1371/Journal.Ppat.0030150  1
2003 LaCount DJ, Gruszynski AE, Grandgenett PM, Bangs JD, Donelson JE. Expression and function of the Trypanosoma brucei major surface protease (GP63) genes. The Journal of Biological Chemistry. 278: 24658-64. PMID 12707278 DOI: 10.1074/Jbc.M301451200  1
2000 Grandgenett PM, Coughlin BC, Kirchhoff LV, Donelson JE. Differential expression of GP63 genes in Trypanosoma cruzi. Molecular and Biochemical Parasitology. 110: 409-15. PMID 11071294 DOI: 10.1016/S0166-6851(00)00275-9  1
2000 Hill KL, Hutchings NR, Grandgenett PM, Donelson JE. T lymphocyte-triggering factor of african trypanosomes is associated with the flagellar fraction of the cytoskeleton and represents a new family of proteins that are present in several divergent eukaryotes. The Journal of Biological Chemistry. 275: 39369-78. PMID 10969087 DOI: 10.1074/Jbc.M006907200  1
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