Roman V. Shchepin, Ph.D. - Publications

Affiliations: 
2006 The University of Nebraska - Lincoln, Lincoln, NE 
Area:
Organic Chemistry, Biochemistry

54 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Chukanov NV, Shchepin RV, Joshi SM, Kabir MSH, Salnikov OG, Svyatova A, Koptyug IV, Gelovani JG, Chekmenev EY. Synthetic Approaches for N-Labeled Hyperpolarized Heterocyclic Molecular Imaging Agents for N NMR Signal Amplification by Reversible Exchange in Microtesla Magnetic Fields. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 33856077 DOI: 10.1002/chem.202100212  0.347
2020 Shchepina NE, Avrorin VV, Badun GA, Shurov SN, Shchepin RV. Chemical effects of nuclear transformations and possible formation of unknown derivatives with N-phenylquinazolinium structure Radiochimica Acta. 108: 105-111. DOI: 10.1515/Ract-2018-2970  0.303
2019 Salnikov OG, Chukanov NV, Shchepin RV, Manzanera Esteve IV, Kovtunov KV, Koptyug IV, Chekmenev EY. Parahydrogen-Induced Polarization of 1-C-Acetates and 1-C-Pyruvates Using Sidearm Hydrogenation of Vinyl, Allyl, and Propargyl Esters. The Journal of Physical Chemistry. C, Nanomaterials and Interfaces. 123: 12827-12840. PMID 31363383 DOI: 10.1021/Acs.Jpcc.9B02041  0.403
2019 Shchepin RV, Birchall JR, Chukanov NV, Kovtunov KV, Koptyug IV, Theis T, Warren WS, Gelovani JG, Goodson BM, Shokouhi S, Rosen MS, Yen YF, Pham W, Chekmenev EY. Hyperpolarizing Concentrated Metronidazole 15NO2 Group Over Six Chemical Bonds with More Than 15% Polarization and 20 Minute Lifetime. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 30964568 DOI: 10.1002/Chem.201901192  0.421
2018 Salnikov OG, Shchepin RV, Chukanov NV, Jaigirdar L, Pham W, Kovtunov KV, Koptyug IV, Chekmenev EY. Effects of Deuteration of C-Enriched Phospholactate on Efficiency of Parahydrogen-Induced Polarization by Magnetic Field Cycling. The Journal of Physical Chemistry. C, Nanomaterials and Interfaces. 122: 24740-24749. PMID 31447960 DOI: 10.1021/Acs.Jpcc.8B07365  0.427
2018 Chukanov NV, Salnikov OG, Shchepin RV, Svyatova A, Kovtunov KV, Koptyug IV, Chekmenev EY. F Hyperpolarization of N-3-F-Pyridine Via Signal Amplification by Reversible Exchange. The Journal of Physical Chemistry. C, Nanomaterials and Interfaces. 122: 23002-23010. PMID 31435456 DOI: 10.1021/Acs.Jpcc.8B06654  0.356
2018 Kidd BE, Gesiorski JL, Gemeinhardt ME, Shchepin RV, Kovtunov KV, Koptyug IV, Chekmenev EY, Goodson BM. Facile Removal of Homogeneous SABRE Catalysts for Purifying Hyperpolarized Metronidazole, a Potential Hypoxia Sensor. The Journal of Physical Chemistry. C, Nanomaterials and Interfaces. 122: 16848-16852. PMID 30559921 DOI: 10.1021/Acs.Jpcc.8B05758  0.399
2018 Chukanov NV, Kidd BM, Kovtunova LM, Bukhtiyarov VI, Shchepin RV, Chekmenev EY, Goodson BM, Kovtunov KV, Koptyug IV. A versatile synthetic route to the preparation of N heterocycles. Journal of Labelled Compounds & Radiopharmaceuticals. PMID 30537260 DOI: 10.1002/Jlcr.3699  0.386
2018 Theis T, Ariyasingha NM, Shchepin RV, Lindale J, Warren WS, Chekmenev EY. Quasi-Resonance Signal Amplification By Reversible Exchange. The Journal of Physical Chemistry Letters. PMID 30284835 DOI: 10.1021/Acs.Jpclett.8B02669  0.39
2018 Shchepin RV, Jaigirdar L, Chekmenev EY. Spin-Lattice Relaxation of Hyperpolarized Metronidazole in Signal Amplification by Reversible Exchange in Micro-Tesla Fields. The Journal of Physical Chemistry. C, Nanomaterials and Interfaces. 122: 4984-4996. PMID 29955244 DOI: 10.1021/Acs.Jpcc.8B00283  0.435
2018 Hovener J, Pravdivtsev AN, Kidd B, Bowers CR, Glöggler S, Kovtunov KV, Plaumann M, Katz-Brull R, Buckenmaier K, Jerschow A, Reineri F, Theis T, Shchepin RV, Wagner S, Zacharias NMM, et al. Parahydrogen-based Hyperpolarization for Biomedicine. Angewandte Chemie (International Ed. in English). PMID 29484795 DOI: 10.1002/Anie.201711842  0.378
2017 Kovtunov KV, Kidd BE, Salnikov OG, Bales LB, Gemeinhardt ME, Gesiorski J, Shchepin RV, Chekmenev EY, Goodson BM, Koptyug IV. Imaging of Biomolecular NMR Signals Amplified by Reversible Exchange with Parahydrogen Inside an MRI Scanner. The Journal of Physical Chemistry. C, Nanomaterials and Interfaces. 121: 25994-25999. PMID 30701013 DOI: 10.1021/Acs.Jpcc.7B10549  0.416
2017 Shchepin RV, Jaigirdar L, Theis T, Warren WS, Goodson BM, Chekmenev EY. Spin Relays Enable Efficient Long-Range Heteronuclear Signal Amplification By Reversible Exchange. The Journal of Physical Chemistry. C, Nanomaterials and Interfaces. 121: 28425-28434. PMID 29955243 DOI: 10.1021/Acs.Jpcc.7B11485  0.416
2017 Bales LB, Kovtunov KV, Barskiy DA, Shchepin RV, Coffey AM, Kovtunova LM, Bukhtiyarov AV, Feldman MA, Bukhtiyarov VI, Chekmenev EY, Koptyug IV, Goodson BM. Aqueous, Heterogeneous Parahydrogen-Induced 15N Polarization. The Journal of Physical Chemistry. C, Nanomaterials and Interfaces. 121: 15304-15309. PMID 29238438 DOI: 10.1021/Acs.Jpcc.7B05912  0.405
2017 Coffey AM, Shchepin RV, Feng B, Colon RD, Wilkens K, Waddell KW, Chekmenev EY. A pulse programmable parahydrogen polarizer using a tunable electromagnet and dual channel NMR spectrometer. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 284: 115-124. PMID 29028543 DOI: 10.1016/J.Jmr.2017.09.013  0.407
2017 Coffey AM, Feldman MA, Shchepin RV, Barskiy DA, Truong ML, Pham W, Chekmenev EY. High-resolution hyperpolarized in vivo metabolic (13)C spectroscopy at low magnetic field (48.7mT) following murine tail-vein injection. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 281: 246-252. PMID 28651245 DOI: 10.1016/J.Jmr.2017.06.009  0.394
2017 Zhou Z, Yu J, Colell JFP, Laasner R, Logan AWJ, Barskiy DA, Shchepin RV, Chekmenev EY, Blum V, Warren WS, Theis T. Long-Lived (13)C2 Nuclear Spin States Hyperpolarized by Parahydrogen in Reversible Exchange at Micro-Tesla Fields. The Journal of Physical Chemistry Letters. PMID 28594557 DOI: 10.1021/Acs.Jpclett.7B00987  0.407
2017 Shchepin RV, Goodson BM, Theis T, Warren WS, Chekmenev EY. Toward Hyperpolarized 19F Molecular Imaging via Reversible Exchange with Parahydrogen. Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. PMID 28557156 DOI: 10.1002/Cphc.201700594  0.348
2017 Barskiy DA, Shchepin RV, Tanner CPN, Colell JFP, Goodson BM, Theis T, Warren WS, Chekmenev EY. The Absence of Quadrupolar Nuclei Facilitates Efficient (13) C Hyperpolarization via Reversible Exchange with Parahydrogen. Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. PMID 28517362 DOI: 10.1002/Cphc.201700416  0.44
2017 Colell JFP, Emondts M, Logan AWJ, Shen K, Bae J, Shchepin RV, Ortiz GX, Spannring P, Wang Q, Malcolmson SJ, Chekmenev EY, Feiters MC, Rutjes FPJT, Bluemich B, Theis T, et al. Direct Hyperpolarization of Nitrogen-15 in Aqueous Media with Parahydrogen in Reversible Exchange. Journal of the American Chemical Society. PMID 28443329 DOI: 10.1021/Jacs.7B00569  0.375
2017 Colell JF, Logan AW, Zhou Z, Shchepin RV, Barskiy DA, Ortiz GX, Wang Q, Malcolmson SJ, Chekmenev EY, Warren WS, Theis T. Generalizing, Extending, and Maximizing Nitrogen-15 Hyperpolarization Induced by Parahydrogen in Reversible Exchange. The Journal of Physical Chemistry. C, Nanomaterials and Interfaces. 121: 6626-6634. PMID 28392884 DOI: 10.1021/Acs.Jpcc.6B12097  0.4
2017 Shchepina NE, Avrorin VV, Badun GA, Shurov SN, Shchepin RV. Nuclear-chemical synthesis of tritium-labeled fluorinated isoquinolinium derivatives Radiochemistry. 59: 297-300. DOI: 10.1134/S1066362217030134  0.331
2016 Barskiy DA, Salnikov OG, Shchepin RV, Feldman MA, Coffey AM, Kovtunov KV, Koptyug IV, Chekmenev EY. NMR SLIC Sensing of Hydrogenation Reactions Using Parahydrogen in Low Magnetic Fields. The Journal of Physical Chemistry. C, Nanomaterials and Interfaces. 120: 29098-29106. PMID 28066517 DOI: 10.1021/Acs.Jpcc.6B07555  0.409
2016 Kovtunov KV, Barskiy DA, Salnikov OG, Shchepin RV, Coffey AM, Kovtunova LM, Bukhtiyarov VI, Koptyug IV, Chekmenev EY. Toward Production of Pure (13)C Hyperpolarized Metabolites Using Heterogeneous Parahydrogen-Induced Polarization of Ethyl[1-(13)C]acetate. Rsc Advances. 6: 69728-69732. PMID 28042472 DOI: 10.1039/C6Ra15808K  0.374
2016 Kovtunov KV, Barskiy DA, Shchepin RV, Salnikov OG, Prosvirin IP, Bukhtiyarov AV, Kovtunova LM, Bukhtiyarov VI, Koptyug IV, Chekmenev EY. Production of Pure Aqueous 13C-Hyperpolarized Acetate Via Heterogeneous Parahydrogen-Induced Polarization. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27607402 DOI: 10.1002/Chem.201603974  0.401
2016 Coffey AM, Shchepin RV, Truong ML, Wilkens K, Pham W, Chekmenev EY. Open-Source Automated Parahydrogen Hyperpolarizer for Molecular Imaging Using (13)C Metabolic Contrast Agents. Analytical Chemistry. PMID 27478927 DOI: 10.1021/Acs.Analchem.6B02130  0.373
2016 Shchepin RV, Barskiy DA, Coffey AM, Theis T, Shi F, Warren WS, Goodson BM, Chekmenev EY. (15)N Hyperpolarization of Imidazole-(15)N2 for Magnetic Resonance pH Sensing via SABRE-SHEATH. Acs Sensors. 1: 640-644. PMID 27379344 DOI: 10.1021/Acssensors.6B00231  0.359
2016 Shi F, He P, Best QA, Groome K, Truong ML, Coffey AM, Zimay G, Shchepin RV, Waddell KW, Chekmenev EY, Goodson BM. Aqueous NMR Signal Enhancement by Reversible Exchange in a Single Step Using Water-Soluble Catalysts. The Journal of Physical Chemistry. C, Nanomaterials and Interfaces. 120: 12149-12156. PMID 27350846 DOI: 10.1021/Acs.Jpcc.6B04484  0.306
2016 Barskiy DA, Shchepin RV, Coffey AM, Theis T, Warren WS, Goodson BM, Chekmenev EY. Over 20% 15N Hyperpolarization in Under One Minute for Metronidazole, an Antibiotic and Hypoxia Probe. Journal of the American Chemical Society. PMID 27321159 DOI: 10.1021/Jacs.6B04784  0.399
2016 Shchepin RV, Barskiy DA, Coffey AM, Manzanera Esteve IV, Chekmenev EY. Efficient Synthesis of Molecular Precursors for Para-hydrogen-Induced Polarization of Ethyl Acetate-1-(13) C and Beyond. Angewandte Chemie (International Ed. in English). PMID 27061815 DOI: 10.1002/Anie.201600521  0.421
2016 Shchepin RV, Barskiy DA, Mikhaylov DM, Chekmenev EY. Efficient Synthesis of Nicotinamide-1-15N for Ultrafast NMR Hyperpolarization Using Parahydrogen. Bioconjugate Chemistry. PMID 26999571 DOI: 10.1021/Acs.Bioconjchem.6B00148  0.395
2015 Shchepin RV, Truong ML, Theis T, Coffey AM, Shi F, Waddell KW, Warren WS, Goodson BM, Chekmenev EY. Hyperpolarization of "Neat" Liquids by NMR Signal Amplification by Reversible Exchange. The Journal of Physical Chemistry Letters. 6: 1961-1967. PMID 26029349 DOI: 10.1021/Acs.Jpclett.5B00782  0.424
2015 Truong ML, Theis T, Coffey AM, Shchepin RV, Waddell KW, Shi F, Goodson BM, Warren WS, Chekmenev EY. (15)N Hyperpolarization by Reversible Exchange Using SABRE-SHEATH. The Journal of Physical Chemistry. C, Nanomaterials and Interfaces. 119: 8786-8797. PMID 25960823 DOI: 10.1021/Acs.Jpcc.5B01799  0.449
2015 Theis T, Truong ML, Coffey AM, Shchepin RV, Waddell KW, Shi F, Goodson BM, Warren WS, Chekmenev EY. Microtesla SABRE enables 10% nitrogen-15 nuclear spin polarization. Journal of the American Chemical Society. 137: 1404-7. PMID 25583142 DOI: 10.1021/Ja512242D  0.414
2014 Truong ML, Shi F, He P, Yuan B, Plunkett KN, Coffey AM, Shchepin RV, Barskiy DA, Kovtunov KV, Koptyug IV, Waddell KW, Goodson BM, Chekmenev EY. Irreversible catalyst activation enables hyperpolarization and water solubility for NMR signal amplification by reversible exchange. The Journal of Physical Chemistry. B. 118: 13882-9. PMID 25372972 DOI: 10.1021/Jp510825B  0.331
2014 Barskiy DA, Kovtunov KV, Koptyug IV, He P, Groome KA, Best QA, Shi F, Goodson BM, Shchepin RV, Truong ML, Coffey AM, Waddell KW, Chekmenev EY. In situ and ex situ low-field NMR spectroscopy and MRI endowed by SABRE hyperpolarization. Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. 15: 4100-7. PMID 25367202 DOI: 10.1002/Cphc.201402607  0.344
2014 Coffey AM, Kovtunov KV, Barskiy DA, Koptyug IV, Shchepin RV, Waddell KW, He P, Groome KA, Best QA, Shi F, Goodson BM, Chekmenev EY. High-resolution low-field molecular magnetic resonance imaging of hyperpolarized liquids. Analytical Chemistry. 86: 9042-9. PMID 25162371 DOI: 10.1021/Ac501638P  0.356
2014 Shchepin RV, Chekmenev EY. Toward hyperpolarized molecular imaging of HIV: synthesis and longitudinal relaxation properties of (15) N-Azidothymidine. Journal of Labelled Compounds & Radiopharmaceuticals. 57: 621-4. PMID 25156931 DOI: 10.1002/Jlcr.3220  0.348
2014 Shchepin RV, Pham W, Chekmenev EY. Dephosphorylation and biodistribution of 1-¹³C-phospholactate in vivo. Journal of Labelled Compounds & Radiopharmaceuticals. 57: 517-24. PMID 24995802 DOI: 10.1002/Jlcr.3207  0.395
2014 Kovtunov KV, Barskiy DA, Shchepin RV, Coffey AM, Waddell KW, Koptyug IV, Chekmenev EY. Demonstration of heterogeneous parahydrogen induced polarization using hyperpolarized agent migration from dissolved Rh(I) complex to gas phase. Analytical Chemistry. 86: 6192-6. PMID 24918975 DOI: 10.1021/Ac5013859  0.367
2014 Truong ML, Coffey AM, Shchepin RV, Waddell KW, Chekmenev EY. Sub-second proton imaging of 13C hyperpolarized contrast agents in water. Contrast Media & Molecular Imaging. 9: 333-41. PMID 24753438 DOI: 10.1002/Cmmi.1579  0.372
2014 Shchepin RV, Coffey AM, Waddell KW, Chekmenev EY. Parahydrogen induced polarization of 1-(13)C-phospholactate-d(2) for biomedical imaging with >30,000,000-fold NMR signal enhancement in water. Analytical Chemistry. 86: 5601-5. PMID 24738968 DOI: 10.1021/Ac500952Z  0.396
2014 Barskiy DA, Kovtunov KV, Koptyug IV, He P, Groome KA, Best QA, Shi F, Goodson BM, Shchepin RV, Coffey AM, Waddell KW, Chekmenev EY. The feasibility of formation and kinetics of NMR signal amplification by reversible exchange (SABRE) at high magnetic field (9.4 T). Journal of the American Chemical Society. 136: 3322-5. PMID 24528143 DOI: 10.1021/Ja501052P  0.391
2013 Shchepin RV, Chekmenev EY. Synthetic approach for unsaturated precursors for parahydrogen induced polarization of choline and its analogs. Journal of Labelled Compounds & Radiopharmaceuticals. 56: 655-62. PMID 25196027 DOI: 10.1002/Jlcr.3082  0.369
2013 Shchepin RV, Liu W, Yin H, Zagol-Ikapitte I, Amin T, Jeong BS, Roberts LJ, Oates JA, Porter NA, Boutaud O. Rational Design of Novel Pyridinol-Fused Ring Acetaminophen Analogues. Acs Medicinal Chemistry Letters. 4: 710-714. PMID 24482730 DOI: 10.1021/Ml4000904  0.465
2013 Cai C, Coffey AM, Shchepin RV, Chekmenev EY, Waddell KW. Efficient transformation of parahydrogen spin order into heteronuclear magnetization. The Journal of Physical Chemistry. B. 117: 1219-24. PMID 23214962 DOI: 10.1021/Jp3089462  0.353
2012 Shchepin RV, Coffey AM, Waddell KW, Chekmenev EY. Parahydrogen Induced Polarization with Rh-based Monodentate Ligand in Water. The Journal of Physical Chemistry Letters. 3: 3281-3285. PMID 23227297 DOI: 10.1021/Jz301389R  0.336
2012 Coffey AM, Shchepin RV, Wilkens K, Waddell KW, Chekmenev EY. A large volume double channel 1H-X RF probe for hyperpolarized magnetic resonance at 0.0475 T. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 220: 94-101. PMID 22706029 DOI: 10.1016/J.Jmr.2012.04.012  0.391
2012 Shchepin RV, Coffey AM, Waddell KW, Chekmenev EY. PASADENA hyperpolarized 13C phospholactate. Journal of the American Chemical Society. 134: 3957-60. PMID 22352377 DOI: 10.1021/Ja210639C  0.414
2010 Shchepin R, Möller MN, Kim HY, Hatch DM, Bartesaghi S, Kalyanaraman B, Radi R, Porter NA. Tyrosine-lipid peroxide adducts from radical termination: para coupling and intramolecular Diels-Alder cyclization. Journal of the American Chemical Society. 132: 17490-500. PMID 21090613 DOI: 10.1021/Ja106503A  0.482
2010 Shchepin R, Xu C, Dussault P. B(C6F5)3-promoted tandem silylation and intramolecular hydrosilylation: diastereoselective synthesis of oxasilinanes and oxasilepanes. Organic Letters. 12: 4772-5. PMID 20919715 DOI: 10.1021/Ol1018757  0.599
2008 Shchepin R, Navarathna DH, Dumitru R, Lippold S, Nickerson KW, Dussault PH. Influence of heterocyclic and oxime-containing farnesol analogs on quorum sensing and pathogenicity in Candida albicans. Bioorganic & Medicinal Chemistry. 16: 1842-8. PMID 18037299 DOI: 10.1016/J.Bmc.2007.11.011  0.553
2005 Shchepin R, Dumitru R, Nickerson KW, Lund M, Dussault PH. Biologically active fluorescent farnesol analogs. Chemistry & Biology. 12: 639-41. PMID 15975508 DOI: 10.1016/J.Chembiol.2005.04.008  0.52
2003 Shchepin R, Hornby JM, Burger E, Niessen T, Dussault P, Nickerson KW. Quorum sensing in Candida albicans: probing farnesol's mode of action with 40 natural and synthetic farnesol analogs. Chemistry & Biology. 10: 743-50. PMID 12954333 DOI: 10.1016/S1074-5521(03)00158-3  0.556
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