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Steven G. Clarke - Publications

Chemistry and Biochemistry and the Molecular Biology Institute University of California, Los Angeles, Los Angeles, CA 
macromolecular repair for DNA and proteins

234 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Warmack RA, Pang EZ, Peluso E, Lowenson JD, Ong JY, Torres JZ, Clarke SG. Human Protein-l-isoaspartate -Methyltransferase Domain-Containing Protein 1 (PCMTD1) Associates with Cullin-RING Ligase Proteins. Biochemistry. PMID 35486881 DOI: 10.1021/acs.biochem.2c00130  0.365
2021 Gladyshev VN, Kritchevsky SB, Clarke SG, Cuervo AM, Fiehn O, de Magalhães JP, Mau T, Maes M, Moritz R, Niedernhofer LJ, Van Schaftingen E, Tranah GJ, Walsh K, Yura Y, Zhang B, et al. Molecular Damage in Aging. Nature Aging. 1: 1096-1106. PMID 36846190 DOI: 10.1038/s43587-021-00150-3  0.363
2020 Dennis TN, Kenjić N, Kang AS, Lowenson JD, Kirkwood JS, Clarke SG, Jefferson P Perry J. Human ARMT1 structure and substrate specificity indicates that it is a DUF89 family damage-control phosphatase. Journal of Structural Biology. 107576. PMID 32682077 DOI: 10.1016/J.Jsb.2020.107576  0.41
2020 Lowe TL, Vernon A, Clarke SG. Protein Arginine Methyltransferase 7 (PRMT7): A Human Enzyme Often Overexpressed in Cancer is Most Active Under Non‐physiological Conditions The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.05667  0.39
2019 White JT, Cato T, Deramchi N, Gabunilas J, Roy K, Wang C, Chanfreau GF, Clarke SG. Protein methylation and translation: Role of lysine modification on the function of yeast elongation factor 1A. Biochemistry. PMID 31738538 DOI: 10.1021/Acs.Biochem.9B00818  0.517
2019 Warmack RA, Shawa H, Liu K, Lopez K, Loo JA, Horwitz J, Clarke SG. The L-isoaspartate modification within protein fragments in the aging lens can promote protein aggregation. The Journal of Biological Chemistry. PMID 31239355 DOI: 10.1074/Jbc.Ra119.009052  0.368
2019 Urzica E, Casero D, Yamasaki H, Hsieh SI, Adler LN, Karpowicz SJ, Blaby-Haas C, Clarke SG, Loo JA, Pellegrini M, Merchant SS. CORRECTION: Systems and trans-system level analysis identifies conserved iron deficiency responses in the plant lineage. The Plant Cell. PMID 30952825 DOI: 10.1105/tpc.19.00217  0.659
2019 Jain K, Clarke SG. PRMT7 as a unique member of the protein arginine methyltransferase family: A review. Archives of Biochemistry and Biophysics. PMID 30802433 DOI: 10.1016/J.Abb.2019.02.014  0.818
2019 Petrossian T, Clarke S. Bioinformatic Identification of Novel Methyltransferases. Epigenomics. 1: 163-175. PMID 20582239 DOI: 10.2217/Epi.09.3  0.406
2018 Clarke SG. The ribosome: A hot spot for the identification of new types of protein methyltransferases. The Journal of Biological Chemistry. PMID 29743234 DOI: 10.1074/Jbc.Aw118.003235  0.561
2017 Yang ML, Doyle H, Clarke SG, Herold K, Mamula M. Oxidative Modifications in Tissue Pathology and Autoimmune Disease. Antioxidants & Redox Signaling. PMID 29088923 DOI: 10.1089/Ars.2017.7382  0.384
2017 Jain K, Jin CY, Clarke SG. Epigenetic control via allosteric regulation of mammalian protein arginine methyltransferases. Proceedings of the National Academy of Sciences of the United States of America. PMID 28874563 DOI: 10.1073/Pnas.1706978114  0.821
2017 Hadjikyriacou A, Clarke SG. Caenorhabditis elegans PRMT-7 and PRMT-9 Are Evolutionarily Conserved Protein Arginine Methyltransferases with Distinct Substrate Specificities. Biochemistry. PMID 28441492 DOI: 10.1021/Acs.Biochem.7B00283  0.445
2016 Kafkova L, Debler EW, Fisk JC, Jain K, Clarke SG, Read LK. The Major Protein Arginine Methyltransferase in Trypanosoma brucei Functions as an Enzyme-Prozyme Complex. The Journal of Biological Chemistry. PMID 27998975 DOI: 10.1074/Jbc.M116.757112  0.811
2016 Caslavka Zempel KE, Vashisht AA, Barshop WD, Wohlschlegel JA, Clarke SG. Determining the Mitochondrial Methyl Proteome in Saccharomyces cerevisiae using Heavy Methyl SILAC. Journal of Proteome Research. PMID 27696855 DOI: 10.1021/Acs.Jproteome.6B00521  0.431
2016 Jain K, Warmack RA, Debler EW, Hadjikyriacou A, Stavropoulos P, Clarke SG. Protein Arginine Methyltransferase Product Specificity is Mediated by Distinct Active-Site Architectures. The Journal of Biological Chemistry. PMID 27387499 DOI: 10.1074/Jbc.M116.740399  0.806
2016 Lowenson JD, Shmanai VV, Shklyaruck D, Clarke SG, Shchepinov MS. Deuteration protects asparagine residues against racemization. Amino Acids. PMID 27169868 DOI: 10.1007/S00726-016-2250-Z  0.35
2016 Sherkhanov S, Korman TP, Clarke SG, Bowie JU. Production of FAME biodiesel in E. coli by direct methylation with an insect enzyme. Scientific Reports. 6: 24239. PMID 27053100 DOI: 10.1038/Srep24239  0.378
2016 Debler EW, Jain K, Warmack RA, Feng Y, Clarke SG, Blobel G, Stavropoulos P. A glutamate/aspartate switch controls product specificity in a protein arginine methyltransferase. Proceedings of the National Academy of Sciences of the United States of America. PMID 26858449 DOI: 10.1073/Pnas.1525783113  0.81
2016 Al-Hadid Q, Roy K, Chanfreau G, Clarke SG. Methylation of yeast ribosomal protein Rpl3 promotes translational elongation fidelity. Rna (New York, N.Y.). PMID 26826131 DOI: 10.1261/Rna.054569.115  0.499
2016 Al-Hadid Q, White J, Clarke S. Ribosomal protein methyltransferases in the yeast Saccharomyces cerevisiae: Roles in ribosome biogenesis and translation. Biochemical and Biophysical Research Communications. 470: 552-7. PMID 26801560 DOI: 10.1016/J.Bbrc.2016.01.107  0.488
2016 Al-Hadid Q, White J, Clarke S. Ribosomal protein methyltransferases in the yeast Saccharomyces cerevisiae: Roles in ribosome biogenesis and translation Biochemical and Biophysical Research Communications. 470: 552-557. DOI: 10.1016/j.bbrc.2016.01.107  0.312
2015 Hadjikyriacou A, Yang Y, Espejo A, Bedford MT, Clarke SG. Unique Features of Human Protein Arginine Methyltransferase 9 (PRMT9) and its Substrate RNA Splicing Factor SF3B2. The Journal of Biological Chemistry. PMID 25979344 DOI: 10.1074/Jbc.M115.659433  0.496
2015 Yang Y, Hadjikyriacou A, Xia Z, Gayatri S, Kim D, Zurita-Lopez C, Kelly R, Guo A, Li W, Clarke SG, Bedford MT. PRMT9 is a type II methyltransferase that methylates the splicing factor SAP145. Nature Communications. 6: 6428. PMID 25737013 DOI: 10.1038/Ncomms7428  0.826
2015 Patananan AN, Budenholzer LM, Pedraza ME, Torres ER, Adler LN, Clarke SG. The invertebrate Caenorhabditis elegans biosynthesizes ascorbate. Archives of Biochemistry and Biophysics. 569: 32-44. PMID 25668719 DOI: 10.1016/J.Abb.2015.02.002  0.782
2015 Patananan AN, Budenholzer LM, Eskin A, Torres ER, Clarke SG. Ethanol-induced differential gene expression and acetyl-CoA metabolism in a longevity model of the nematode Caenorhabditis elegans. Experimental Gerontology. 61: 20-30. PMID 25449858 DOI: 10.1016/J.Exger.2014.11.010  0.722
2014 Dzialo MC, Travaglini KJ, Shen S, Loo JA, Clarke SG. A new type of protein lysine methyltransferase trimethylates Lys-79 of elongation factor 1A. Biochemical and Biophysical Research Communications. 455: 382-9. PMID 25446118 DOI: 10.1016/J.Bbrc.2014.11.022  0.488
2014 Feng Y, Hadjikyriacou A, Clarke SG. Substrate specificity of human protein arginine methyltransferase 7 (PRMT7): the importance of acidic residues in the double E loop. The Journal of Biological Chemistry. 289: 32604-16. PMID 25294873 DOI: 10.1074/Jbc.M114.609271  0.522
2014 Dzialo MC, Travaglini KJ, Shen S, Roy K, Chanfreau GF, Loo JA, Clarke SG. Translational roles of elongation factor 2 protein lysine methylation. The Journal of Biological Chemistry. 289: 30511-24. PMID 25231983 DOI: 10.1074/Jbc.M114.605527  0.48
2014 Al-Hadid Q, Roy K, Munroe W, Dzialo MC, Chanfreau GF, Clarke SG. Histidine methylation of yeast ribosomal protein Rpl3p is required for proper 60S subunit assembly. Molecular and Cellular Biology. 34: 2903-16. PMID 24865971 DOI: 10.1128/Mcb.01634-13  0.526
2014 Patananan AN, Capri J, Whitelegge JP, Clarke SG. Non-repair pathways for minimizing protein isoaspartyl damage in the yeast Saccharomyces cerevisiae. The Journal of Biological Chemistry. 289: 16936-53. PMID 24764295 DOI: 10.1074/Jbc.M114.564385  0.793
2014 Hadjikyriacou A, Yang Y, Bedford M, Clarke S. Characterization of the Activity and Biological Function of Human Protein Arginine Methyltransferase 9 (PRMT9) The Faseb Journal. 29. DOI: 10.1096/Fasebj.29.1_Supplement.Lb211  0.486
2013 Shen-Miller J, Lindner P, Xie Y, Villa S, Wooding K, Clarke SG, Loo RR, Loo JA. Thermal-stable proteins of fruit of long-living Sacred Lotus Nelumbo nucifera Gaertn var. China Antique. Tropical Plant Biology. 6. PMID 24363819 DOI: 10.1007/S12042-013-9124-2  0.795
2013 Feng Y, Maity R, Whitelegge JP, Hadjikyriacou A, Li Z, Zurita-Lopez C, Al-Hadid Q, Clark AT, Bedford MT, Masson JY, Clarke SG. Mammalian protein arginine methyltransferase 7 (PRMT7) specifically targets RXR sites in lysine- and arginine-rich regions. The Journal of Biological Chemistry. 288: 37010-25. PMID 24247247 DOI: 10.1074/Jbc.M113.525345  0.835
2013 Lissina E, Weiss D, Young B, Rella A, Cheung-Ong K, Del Poeta M, Clarke SG, Giaever G, Nislow C. A novel small molecule methyltransferase is important for virulence in Candida albicans. Acs Chemical Biology. 8: 2785-93. PMID 24083538 DOI: 10.1021/Cb400607H  0.301
2013 Yang H, Lowenson JD, Clarke S, Zubarev RA. Brain proteomics supports the role of glutamate metabolism and suggests other metabolic alterations in protein l-isoaspartyl methyltransferase (PIMT)-knockout mice. Journal of Proteome Research. 12: 4566-76. PMID 23947766 DOI: 10.1021/Pr400688R  0.403
2013 Nayak NR, Putnam AA, Addepalli B, Lowenson JD, Chen T, Jankowsky E, Perry SE, Dinkins RD, Limbach PA, Clarke SG, Downie AB. An Arabidopsis ATP-dependent, DEAD-box RNA helicase loses activity upon IsoAsp formation but is restored by PROTEIN ISOASPARTYL METHYLTRANSFERASE. The Plant Cell. 25: 2573-86. PMID 23903319 DOI: 10.1105/Tpc.113.113456  0.442
2013 MacKay KB, Tu Y, Young SG, Clarke SG. Circumventing embryonic lethality with Lcmt1 deficiency: generation of hypomorphic Lcmt1 mice with reduced protein phosphatase 2A methyltransferase expression and defects in insulin signaling. Plos One. 8: e65967. PMID 23840384 DOI: 10.1371/Journal.Pone.0065967  0.797
2013 Patananan AN, Palmer JM, Garvey GS, Keller NP, Clarke SG. A novel automethylation reaction in the Aspergillus nidulans LaeA protein generates S-methylmethionine. The Journal of Biological Chemistry. 288: 14032-45. PMID 23532849 DOI: 10.1074/Jbc.M113.465765  0.811
2013 Clarke SG. Protein methylation at the surface and buried deep: thinking outside the histone box. Trends in Biochemical Sciences. 38: 243-52. PMID 23490039 DOI: 10.1016/J.Tibs.2013.02.004  0.509
2013 Dhar S, Vemulapalli V, Patananan AN, Huang GL, Di Lorenzo A, Richard S, Comb MJ, Guo A, Clarke SG, Bedford MT. Loss of the major Type I arginine methyltransferase PRMT1 causes substrate scavenging by other PRMTs. Scientific Reports. 3: 1311. PMID 23419748 DOI: 10.1038/Srep01311  0.783
2013 Dai S, Ni W, Patananan AN, Clarke SG, Karger BL, Zhou ZS. Integrated proteomic analysis of major isoaspartyl-containing proteins in the urine of wild type and protein L-isoaspartate O-methyltransferase-deficient mice. Analytical Chemistry. 85: 2423-30. PMID 23327623 DOI: 10.1021/Ac303428H  0.781
2013 Yang ML, Gee AJ, Gee RJ, Zurita-Lopez CI, Khare S, Clarke SG, Mamula MJ. Lupus autoimmunity altered by cellular methylation metabolism. Autoimmunity. 46: 21-31. PMID 23039363 DOI: 10.3109/08916934.2012.732133  0.796
2013 Khare S, Linster CL, Clarke SG. Correction: The interplay between protein l-isoaspartyl methyltransferase activity and insulin-like signaling to extend lifespan in caenorhabditis elegans (PLoS ONE) Plos One. 8. DOI: 10.1371/annotation/d6ad8c55-fd3a-4f6c-a2ba-849e4a6500ca  0.538
2013 Patananan AN, Clarke SG. Isoaspartyl Dipeptidase (IadA) Handbook of Proteolytic Enzymes. 2: 1654-1663. DOI: 10.1016/B978-0-12-382219-2.00374-4  0.669
2012 MacKay KB, Lowenson JD, Clarke SG. Wortmannin reduces insulin signaling and death in seizure-prone Pcmt1-/- mice. Plos One. 7: e46719. PMID 23071621 DOI: 10.1371/Journal.Pone.0046719  0.728
2012 Urzica EI, Casero D, Yamasaki H, Hsieh SI, Adler LN, Karpowicz SJ, Blaby-Haas CE, Clarke SG, Loo JA, Pellegrini M, Merchant SS. Systems and trans-system level analysis identifies conserved iron deficiency responses in the plant lineage. The Plant Cell. 24: 3921-48. PMID 23043051 DOI: 10.1105/Tpc.112.102491  0.704
2012 Young BD, Weiss DI, Zurita-Lopez CI, Webb KJ, Clarke SG, McBride AE. Identification of methylated proteins in the yeast small ribosomal subunit: a role for SPOUT methyltransferases in protein arginine methylation. Biochemistry. 51: 5091-104. PMID 22650761 DOI: 10.1021/Bi300186G  0.85
2012 Urzica EI, Adler LN, Page MD, Linster CL, Arbing MA, Casero D, Pellegrini M, Merchant SS, Clarke SG. Impact of oxidative stress on ascorbate biosynthesis in Chlamydomonas via regulation of the VTC2 gene encoding a GDP-L-galactose phosphorylase. The Journal of Biological Chemistry. 287: 14234-45. PMID 22393048 DOI: 10.1074/Jbc.M112.341982  0.734
2012 Castro PV, Khare S, Young BD, Clarke SG. Caenorhabditis elegans battling starvation stress: low levels of ethanol prolong lifespan in L1 larvae. Plos One. 7: e29984. PMID 22279556 DOI: 10.1371/Journal.Pone.0029984  0.538
2012 Zurita-Lopez CI, Sandberg T, Kelly R, Clarke SG. Human protein arginine methyltransferase 7 (PRMT7) is a type III enzyme forming ω-NG-monomethylated arginine residues. The Journal of Biological Chemistry. 287: 7859-70. PMID 22241471 DOI: 10.1074/Jbc.M111.336271  0.815
2012 Lowenson JD, Roher AE, Clarke S. Protein aging Extracellular amyloid formation and intracellular repair. Trends in Cardiovascular Medicine. 4: 3-8. PMID 21244903 DOI: 10.1016/1050-1738(94)90019-1  0.352
2011 Lissina E, Young B, Urbanus ML, Guan XL, Lowenson J, Hoon S, Baryshnikova A, Riezman I, Michaut M, Riezman H, Cowen LE, Wenk MR, Clarke SG, Giaever G, Nislow C. A systems biology approach reveals the role of a novel methyltransferase in response to chemical stress and lipid homeostasis. Plos Genetics. 7: e1002332. PMID 22028670 DOI: 10.1371/Journal.Pgen.1002332  0.38
2011 Khare S, Linster CL, Clarke SG. The interplay between protein L-isoaspartyl methyltransferase activity and insulin-like signaling to extend lifespan in Caenorhabditis elegans. Plos One. 6: e20850. PMID 21695191 DOI: 10.1371/Journal.Pone.0020850  0.628
2011 Adler LN, Gomez TA, Clarke SG, Linster CL. A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals. The Journal of Biological Chemistry. 286: 21511-23. PMID 21507950 DOI: 10.1074/Jbc.M111.238774  0.724
2011 Webb KJ, Al-Hadid Q, Zurita-Lopez CI, Young BD, Lipson RS, Clarke SG. The ribosomal l1 protuberance in yeast is methylated on a lysine residue catalyzed by a seven-beta-strand methyltransferase. The Journal of Biological Chemistry. 286: 18405-13. PMID 21460220 DOI: 10.1074/Jbc.M110.200410  0.84
2011 Rust HL, Zurita-Lopez CI, Clarke S, Thompson PR. Mechanistic studies on transcriptional coactivator protein arginine methyltransferase 1. Biochemistry. 50: 3332-45. PMID 21417440 DOI: 10.1021/Bi102022E  0.818
2011 Butler JS, Zurita-Lopez CI, Clarke SG, Bedford MT, Dent SY. Protein-arginine methyltransferase 1 (PRMT1) methylates Ash2L, a shared component of mammalian histone H3K4 methyltransferase complexes. The Journal of Biological Chemistry. 286: 12234-44. PMID 21285357 DOI: 10.1074/Jbc.M110.202416  0.818
2011 Petrossian TC, Clarke SG. Uncovering the human methyltransferasome. Molecular & Cellular Proteomics : McP. 10: M110.000976. PMID 20930037 DOI: 10.1074/Mcp.M110.000976  0.397
2010 Chen T, Nayak N, Majee SM, Lowenson J, Schäfermeyer KR, Eliopoulos AC, Lloyd TD, Dinkins R, Perry SE, Forsthoefel NR, Clarke SG, Vernon DM, Zhou ZS, Rejtar T, Downie AB. Substrates of the Arabidopsis thaliana protein isoaspartyl methyltransferase 1 identified using phage display and biopanning. The Journal of Biological Chemistry. 285: 37281-92. PMID 20870712 DOI: 10.1074/Jbc.M110.157008  0.491
2010 Webb KJ, Zurita-Lopez CI, Al-Hadid Q, Laganowsky A, Young BD, Lipson RS, Souda P, Faull KF, Whitelegge JP, Clarke SG. A novel 3-methylhistidine modification of yeast ribosomal protein Rpl3 is dependent upon the YIL110W methyltransferase. The Journal of Biological Chemistry. 285: 37598-606. PMID 20864530 DOI: 10.1074/Jbc.M110.170787  0.846
2010 Lipson RS, Webb KJ, Clarke SG. Two novel methyltransferases acting upon eukaryotic elongation factor 1A in Saccharomyces cerevisiae. Archives of Biochemistry and Biophysics. 500: 137-43. PMID 20510667 DOI: 10.1016/J.Abb.2010.05.023  0.842
2010 Webb KJ, Lipson RS, Al-Hadid Q, Whitelegge JP, Clarke SG. Identification of protein N-terminal methyltransferases in yeast and humans. Biochemistry. 49: 5225-35. PMID 20481588 DOI: 10.1021/Bi100428X  0.845
2010 Vinci CR, Clarke SG. Homocysteine methyltransferases Mht1 and Sam4 prevent the accumulation of age-damaged (R,S)-AdoMet in the yeast Saccharomyces cerevisiae. The Journal of Biological Chemistry. 285: 20526-31. PMID 20421295 DOI: 10.1074/Jbc.M110.113076  0.781
2010 Fisk JC, Zurita-Lopez C, Sayegh J, Tomasello DL, Clarke SG, Read LK. TbPRMT6 is a type I protein arginine methyltransferase that contributes to cytokinesis in Trypanosoma brucei. Eukaryotic Cell. 9: 866-77. PMID 20418380 DOI: 10.1128/Ec.00018-10  0.838
2010 Vinci CR, Clarke SG. Yeast, plants, worms, and flies use a methyltransferase to metabolize age-damaged (R,S)-AdoMet, but what do mammals do? Rejuvenation Research. 13: 362-4. PMID 20370499 DOI: 10.1089/Rej.2009.0956  0.78
2010 Lipson RS, Webb KJ, Clarke SG. Rmt1 catalyzes zinc-finger independent arginine methylation of ribosomal protein Rps2 in Saccharomyces cerevisiae. Biochemical and Biophysical Research Communications. 391: 1658-62. PMID 20035717 DOI: 10.1016/J.Bbrc.2009.12.112  0.845
2010 Lakowski TM, Zurita-Lopez C, Clarke SG, Frankel A. Approaches to measuring the activities of protein arginine N-methyltransferases. Analytical Biochemistry. 397: 1-11. PMID 19761747 DOI: 10.1016/J.Ab.2009.09.021  0.818
2009 Khare S, Gomez T, Linster CL, Clarke SG. Defective responses to oxidative stress in protein l-isoaspartyl repair-deficient Caenorhabditis elegans. Mechanisms of Ageing and Development. 130: 670-80. PMID 19682488 DOI: 10.1016/J.Mad.2009.08.002  0.572
2009 Petrossian TC, Clarke SG. Multiple Motif Scanning to identify methyltransferases from the yeast proteome. Molecular & Cellular Proteomics : McP. 8: 1516-26. PMID 19351663 DOI: 10.1074/Mcp.M900025-Mcp200  0.398
2009 Fisk JC, Sayegh J, Zurita-Lopez C, Menon S, Presnyak V, Clarke SG, Read LK. A type III protein arginine methyltransferase from the protozoan parasite Trypanosoma brucei. The Journal of Biological Chemistry. 284: 11590-600. PMID 19254949 DOI: 10.1074/Jbc.M807279200  0.831
2009 Bedford MT, Clarke SG. Protein arginine methylation in mammals: who, what, and why. Molecular Cell. 33: 1-13. PMID 19150423 DOI: 10.1016/J.Molcel.2008.12.013  0.527
2009 Petrossian TC, Clarke SG. Computational methods to identify novel methyltransferases Bmc Bioinformatics. 10: P7. DOI: 10.1186/1471-2105-10-S13-P7  0.417
2008 Gomez TA, Banfield KL, Clarke SG. The protein L-isoaspartyl-O-methyltransferase functions in the Caenorhabditis elegans stress response. Mechanisms of Ageing and Development. 129: 752-8. PMID 18977240 DOI: 10.1016/J.Mad.2008.09.019  0.795
2008 Webb KJ, Laganowsky A, Whitelegge JP, Clarke SG. Identification of two SET domain proteins required for methylation of lysine residues in yeast ribosomal protein Rpl42ab. The Journal of Biological Chemistry. 283: 35561-8. PMID 18957409 DOI: 10.1074/Jbc.M806006200  0.69
2008 Linster CL, Clarke SG. L-Ascorbate biosynthesis in higher plants: the role of VTC2. Trends in Plant Science. 13: 567-73. PMID 18824398 DOI: 10.1016/J.Tplants.2008.08.005  0.363
2008 Banfield KL, Gomez TA, Lee W, Clarke S, Larsen PL. Protein-repair and hormone-signaling pathways specify dauer and adult longevity and dauer development in Caenorhabditis elegans. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 63: 798-808. PMID 18772467 DOI: 10.1093/Gerona/63.8.798  0.784
2008 Sayegh J, Clarke SG. Hsl7 is a substrate-specific type II protein arginine methyltransferase in yeast. Biochemical and Biophysical Research Communications. 372: 811-5. PMID 18515076 DOI: 10.1016/J.Bbrc.2008.05.121  0.842
2008 Linster CL, Adler LN, Webb K, Christensen KC, Brenner C, Clarke SG. A second GDP-L-galactose phosphorylase in arabidopsis en route to vitamin C. Covalent intermediate and substrate requirements for the conserved reaction. The Journal of Biological Chemistry. 283: 18483-92. PMID 18463094 DOI: 10.1074/Jbc.M802594200  0.8
2008 Alfaro JF, Gillies LA, Sun HG, Dai S, Zang T, Klaene JJ, Kim BJ, Lowenson JD, Clarke SG, Karger BL, Zhou ZS. Chemo-enzymatic detection of protein isoaspartate using protein isoaspartate methyltransferase and hydrazine trapping. Analytical Chemistry. 80: 3882-9. PMID 18419136 DOI: 10.1021/Ac800251Q  0.457
2008 Dumlao DS, Hertz N, Clarke S. Secreted 3-isopropylmalate methyl ester signals invasive growth during amino acid starvation in Saccharomyces cerevisiae Biochemistry. 47: 698-709. PMID 18092814 DOI: 10.1021/Bi7018157  0.429
2007 Sayegh J, Webb K, Cheng D, Bedford MT, Clarke SG. Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain. The Journal of Biological Chemistry. 282: 36444-53. PMID 17925405 DOI: 10.1074/Jbc.M704650200  0.821
2007 Lipson RS, Clarke SG. S-adenosylmethionine-dependent protein methylation in mammalian cytosol via tyrphostin modification by catechol-O-methyltransferase. The Journal of Biological Chemistry. 282: 31094-102. PMID 17724020 DOI: 10.1074/Jbc.M705456200  0.833
2007 Clarke SG. HIV protease inhibitors and nuclear lamin processing: getting the right bells and whistles. Proceedings of the National Academy of Sciences of the United States of America. 104: 13857-8. PMID 17709742 DOI: 10.1073/Pnas.0706529104  0.303
2007 Pasternack DA, Sayegh J, Clarke S, Read LK. Evolutionarily divergent type II protein arginine methyltransferase in Trypanosoma brucei. Eukaryotic Cell. 6: 1665-81. PMID 17601874 DOI: 10.1128/Ec.00133-07  0.839
2007 Zou Y, Webb K, Perna AD, Zhang Q, Clarke S, Wang Y. A mass spectrometric study on the in vitro methylation of HMGA1a and HMGA1b proteins by PRMTs: methylation specificity, the effect of binding to AT-rich duplex DNA, and the effect of C-terminal phosphorylation. Biochemistry. 46: 7896-906. PMID 17550233 DOI: 10.1021/Bi6024897  0.688
2007 McBride AE, Zurita-Lopez C, Regis A, Blum E, Conboy A, Elf S, Clarke S. Protein arginine methylation in Candida albicans: Role in nuclear transport Eukaryotic Cell. 6: 1119-1129. PMID 17483287 DOI: 10.1128/Ec.00074-07  0.807
2007 Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG. Arabidopsis VTC2 encodes a GDP-L-galactose phosphorylase, the last unknown enzyme in the Smirnoff-Wheeler pathway to ascorbic acid in plants. The Journal of Biological Chemistry. 282: 18879-85. PMID 17462988 DOI: 10.1074/Jbc.M702094200  0.749
2007 Gomez TA, Clarke SG. Autophagy and insulin/TOR signaling in Caenorhabditis elegans pcm-1 protein repair mutants. Autophagy. 3: 357-9. PMID 17404495 DOI: 10.4161/Auto.4143  0.389
2007 Porras-Yakushi TR, Whitelegge JP, Clarke S. Yeast ribosomal/cytochrome c SET domain methyltransferase subfamily: identification of Rpl23ab methylation sites and recognition motifs. The Journal of Biological Chemistry. 282: 12368-76. PMID 17327221 DOI: 10.1074/Jbc.M611896200  0.825
2007 Vinci CR, Clarke SG. Recognition of age-damaged (R,S)-adenosyl-L-methionine by two methyltransferases in the yeast Saccharomyces cerevisiae. The Journal of Biological Chemistry. 282: 8604-12. PMID 17264075 DOI: 10.1074/Jbc.M610029200  0.79
2007 Gomez TA, Banfield KL, Trogler DM, Clarke SG. The L-isoaspartyl-O-methyltransferase in Caenorhabditis elegans larval longevity and autophagy. Developmental Biology. 303: 493-500. PMID 17187774 DOI: 10.1016/J.Ydbio.2006.11.023  0.797
2006 Clarke SG. 16 Inhibition of mammalian protein methyltransferases by 5'-methylthioadenosine (MTA): A mechanism of action of dietary same? The Enzymes. 24: 467-93. PMID 26718050 DOI: 10.1016/S1874-6047(06)80018-1  0.418
2006 Young SG, Clarke SG, Bergoc MO, Phillips M, Fong LG. 10 Genetic approaches to understanding the physiologic importance of the carboxyl methylation of isoprenylated proteins. The Enzymes. 24: 273-301. PMID 26718044 DOI: 10.1016/S1874-6047(06)80012-0  0.485
2006 Villa ST, Xu Q, Downie AB, Clarke SG. Arabidopsis Protein Repair L-Isoaspartyl Methyltransferases: Predominant Activities at Lethal Temperatures. Physiologia Plantarum. 128: 581-592. PMID 21076691 DOI: 10.1111/J.1399-3054.2006.00772.X  0.804
2006 Porras-Yakushi TR, Whitelegge JP, Clarke S. A novel SET domain methyltransferase in yeast: Rkm2-dependent trimethylation of ribosomal protein L12ab at lysine 10. The Journal of Biological Chemistry. 281: 35835-45. PMID 17005568 DOI: 10.1074/Jbc.M606578200  0.842
2006 Yang ML, Doyle HA, Gee RJ, Lowenson JD, Clarke S, Lawson BR, Aswad DW, Mamula MJ. Intracellular protein modification associated with altered T cell functions in autoimmunity. Journal of Immunology (Baltimore, Md. : 1950). 177: 4541-9. PMID 16982891 DOI: 10.4049/Jimmunol.177.7.4541  0.678
2006 Vigneswara V, Lowenson JD, Powell CD, Thakur M, Bailey K, Clarke S, Ray DE, Carter WG. Proteomic identification of novel substrates of a protein isoaspartyl methyltransferase repair enzyme. The Journal of Biological Chemistry. 281: 32619-29. PMID 16923807 DOI: 10.1074/Jbc.M605421200  0.537
2006 Miranda TB, Sayegh J, Frankel A, Katz JE, Miranda M, Clarke S. Yeast Hsl7 (histone synthetic lethal 7) catalyses the in vitro formation of omega-N(G)-monomethylarginine in calf thymus histone H2A. The Biochemical Journal. 395: 563-70. PMID 16426232 DOI: 10.1042/Bj20051771  0.834
2006 Stetler A, Winograd C, Sayegh J, Cheever A, Patton E, Zhang X, Clarke S, Ceman S. Identification and characterization of the methyl arginines in the fragile X mental retardation protein Fmrp. Human Molecular Genetics. 15: 87-96. PMID 16319129 DOI: 10.1093/Hmg/Ddi429  0.825
2005 Farrar CE, Huang CS, Clarke SG, Houser CR. Increased cell proliferation and granule cell number in the dentate gyrus of protein repair-deficient mice. The Journal of Comparative Neurology. 493: 524-37. PMID 16304629 DOI: 10.1002/Cne.20780  0.779
2005 Miranda TB, Webb KJ, Edberg DD, Reeves R, Clarke S. Protein arginine methyltransferase 6 specifically methylates the nonhistone chromatin protein HMGA1a. Biochemical and Biophysical Research Communications. 336: 831-5. PMID 16157300 DOI: 10.1016/J.Bbrc.2005.08.179  0.842
2005 Farrar CE, Clarke S. Diet-dependent survival of protein repair-deficient mice. The Journal of Nutritional Biochemistry. 16: 554-61. PMID 16115544 DOI: 10.1016/J.Jnutbio.2005.02.004  0.783
2005 Porras-Yakushi TR, Whitelegge JP, Miranda TB, Clarke S. A novel SET domain methyltransferase modifies ribosomal protein Rpl23ab in yeast. The Journal of Biological Chemistry. 280: 34590-8. PMID 16096273 DOI: 10.1074/Jbc.M507672200  0.839
2005 Lee J, Sayegh J, Daniel J, Clarke S, Bedford MT. PRMT8, a new membrane-bound tissue-specific member of the protein arginine methyltransferase family. The Journal of Biological Chemistry. 280: 32890-6. PMID 16051612 DOI: 10.1074/Jbc.M506944200  0.833
2005 Kalhor HR, Penjwini M, Clarke S. A novel methyltransferase required for the formation of the hypermodified nucleoside wybutosine in eucaryotic tRNA. Biochemical and Biophysical Research Communications. 334: 433-40. PMID 16005430 DOI: 10.1016/J.Bbrc.2005.06.111  0.766
2005 Farrar C, Houser CR, Clarke S. Activation of the PI3K/Akt signal transduction pathway and increased levels of insulin receptor in protein repair-deficient mice. Aging Cell. 4: 1-12. PMID 15659208 DOI: 10.1111/J.1474-9728.2004.00136.X  0.783
2004 Miranda TB, Lowenson JD, Clarke S. A new type of protein methylation activated by tyrphostin A25 and vanadate. Febs Letters. 577: 181-6. PMID 15527782 DOI: 10.1016/J.Febslet.2004.09.080  0.789
2004 Miranda TB, Khusial P, Cook JR, Lee JH, Gunderson SI, Pestka S, Zieve GW, Clarke S. Spliceosome Sm proteins D1, D3, and B/B' are asymmetrically dimethylated at arginine residues in the nucleus. Biochemical and Biophysical Research Communications. 323: 382-7. PMID 15369763 DOI: 10.1016/J.Bbrc.2004.08.107  0.724
2004 Xu Q, Belcastro MP, Villa ST, Dinkins RD, Clarke SG, Downie AB. A second protein L-isoaspartyl methyltransferase gene in Arabidopsis produces two transcripts whose products are sequestered in the nucleus. Plant Physiology. 136: 2652-64. PMID 15347786 DOI: 10.1104/Pp.104.046094  0.818
2004 Wang Y, Wysocka J, Sayegh J, Lee YH, Perlin JR, Leonelli L, Sonbuchner LS, McDonald CH, Cook RG, Dou Y, Roeder RG, Clarke S, Stallcup MR, Allis CD, Coonrod SA. Human PAD4 regulates histone arginine methylation levels via demethylimination. Science (New York, N.Y.). 306: 279-83. PMID 15345777 DOI: 10.1126/Science.1101400  0.817
2004 Singh V, Miranda TB, Jiang W, Frankel A, Roemer ME, Robb VA, Gutmann DH, Herschman HR, Clarke S, Newsham IF. DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo. Oncogene. 23: 7761-71. PMID 15334060 DOI: 10.1038/Sj.Onc.1208057  0.819
2004 Vitali R, Clarke S. Improved rotorod performance and hyperactivity in mice deficient in a protein repair methyltransferase. Behavioural Brain Research. 153: 129-41. PMID 15219714 DOI: 10.1016/J.Bbr.2003.11.007  0.393
2004 Katz JE, Dumlao DS, Wasserman JI, Lansdown MG, Jung ME, Faull KF, Clarke S. 3-Isopropylmalate is the major endogenous substrate of the Saccharomyces cerevisiae trans-aconitate methyltransferase. Biochemistry. 43: 5976-86. PMID 15147181 DOI: 10.1021/Bi049784+  0.442
2004 Miranda TB, Miranda M, Frankel A, Clarke S. PRMT7 is a member of the protein arginine methyltransferase family with a distinct substrate specificity. The Journal of Biological Chemistry. 279: 22902-7. PMID 15044439 DOI: 10.1074/Jbc.M312904200  0.84
2004 Clarke S, Tamanoi F. Fighting cancer by disrupting C-terminal methylation of signaling proteins. The Journal of Clinical Investigation. 113: 513-5. PMID 14966560 DOI: 10.1172/Jci21059  0.434
2004 Boulanger MC, Miranda TB, Clarke S, Di Fruscio M, Suter B, Lasko P, Richard S. Characterization of the Drosophila protein arginine methyltransferases DART1 and DART4. The Biochemical Journal. 379: 283-9. PMID 14705965 DOI: 10.1042/Bj20031176  0.807
2003 Kalhor HR, Clarke S. Novel methyltransferase for modified uridine residues at the wobble position of tRNA. Molecular and Cellular Biology. 23: 9283-92. PMID 14645538 DOI: 10.1128/Mcb.23.24.9283-9292.2003  0.763
2003 Katz JE, Dlakić M, Clarke S. Automated identification of putative methyltransferases from genomic open reading frames. Molecular & Cellular Proteomics : McP. 2: 525-40. PMID 12872006 DOI: 10.1074/Mcp.M300037-Mcp200  0.347
2003 Clarke S. Aging as war between chemical and biochemical processes: protein methylation and the recognition of age-damaged proteins for repair. Ageing Research Reviews. 2: 263-285. PMID 12726775 DOI: 10.1016/S1568-1637(03)00011-4  0.503
2003 Mura C, Katz JE, Clarke SG, Eisenberg D. Structure and function of an archaeal homolog of survival protein E (SurEalpha): an acid phosphatase with purine nucleotide specificity. Journal of Molecular Biology. 326: 1559-75. PMID 12595266 DOI: 10.1016/S0022-2836(03)00056-1  0.415
2003 Mura C, Katz JE, Clarke SG, Eisenberg D. Erratum to “Structure and Function of an Archaeal Homolog of Survival Protein E (SurEα): An Acid Phosphatase with Purine Nucleotide Specificity” Journal of Molecular Biology. 328: 517. DOI: 10.1016/S0022-2836(03)00343-7  0.338
2002 Farrar C, Clarke S. Altered levels of S-adenosylmethionine and S-adenosylhomocysteine in the brains of L-isoaspartyl (D-aspartyl) O-methyltransferase-deficient mice Journal of Biological Chemistry. 277: 27856-27863. PMID 12023972 DOI: 10.1074/Jbc.M203911200  0.794
2002 Clarke S. The methylator meets the terminator Proceedings of the National Academy of Sciences of the United States of America. 99: 1104-1106. PMID 11830650 DOI: 10.1073/Pnas.042004099  0.369
2002 Ryttersgaard C, Griffith SC, Sawaya MR, MacLaren DC, Clarke S, Yeates TO. Crystal structure of human L-isoaspartyl methyltransferase. The Journal of Biological Chemistry. 277: 10642-6. PMID 11792715 DOI: 10.1074/Jbc.M200229200  0.427
2002 Frankel A, Yadav N, Lee J, Branscombe TL, Clarke S, Bedford MT. The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity. The Journal of Biological Chemistry. 277: 3537-43. PMID 11724789 DOI: 10.1074/Jbc.M108786200  0.682
2002 Thapar N, Griffith SC, Yeates TO, Clarke S. Protein repair methyltransferase from the hyperthermophilic archaeon Pyrococcus furiosus. Unusual methyl-accepting affinity for D-aspartyl and N-succinyl-containing peptides. The Journal of Biological Chemistry. 277: 1058-65. PMID 11694513 DOI: 10.1074/Jbc.M108261200  0.724
2001 Zhang RG, Skarina T, Katz JE, Beasley S, Khachatryan A, Vyas S, Arrowsmith CH, Clarke S, Edwards A, Joachimiak A, Savchenko A. Structure of Thermotoga maritima stationary phase survival protein SurE: a novel acid phosphatase. Structure (London, England : 1993). 9: 1095-106. PMID 11709173 DOI: 10.1016/S0969-2126(01)00675-X  0.363
2001 Griffith SC, Sawaya MR, Boutz DR, Thapar N, Katz JE, Clarke S, Yeates TO. Crystal structure of a protein repair methyltransferase from Pyrococcus furiosus with its L-isoaspartyl peptide substrate. Journal of Molecular Biology. 313: 1103-16. PMID 11700066 DOI: 10.1006/Jmbi.2001.5095  0.734
2001 Kalhor HR, Luk K, Ramos A, Zobel-Thropp P, Clarke S. Protein phosphatase methyltransferase 1 (Ppm1p) is the sole activity responsible for modification of the major forms of protein phosphatase 2A in yeast. Archives of Biochemistry and Biophysics. 395: 239-45. PMID 11697862 DOI: 10.1006/Abbi.2001.2558  0.798
2001 Cai H, Dumlao D, Katz JE, Clarke S. Identification of the gene and characterization of the activity of the trans-aconitate methyltransferase from Saccharomyces cerevisiae. Biochemistry. 40: 13699-709. PMID 11695919 DOI: 10.1021/Bi011380J  0.443
2001 Cai H, Strouse J, Dumlao D, Jung ME, Clarke S. Distinct reactions catalyzed by bacterial and yeast trans-aconitate methyltransferases. Biochemistry. 40: 2210-9. PMID 11329290 DOI: 10.1021/Bi0022902  0.449
2001 Lowenson JD, Kim E, Young SG, Clarke S. Limited accumulation of damaged proteins in l-isoaspartyl (D-aspartyl) O-methyltransferase-deficient mice. Journal of Biological Chemistry. 276: 20695-20702. PMID 11279164 DOI: 10.1074/Jbc.M100987200  0.343
2001 Thapar N, Kim AK, Clarke S. Distinct patterns of expression but similar biochemical properties of protein L-isoaspartyl methyltransferase in higher plants. Plant Physiology. 125: 1023-35. PMID 11161058 DOI: 10.1104/Pp.125.2.1023  0.699
2001 Zobel-Thropp P, Yang MC, Machado L, Clarke S. A novel post-translational modification of yeast elongation factor 1A. Methylesterification at the C terminus. The Journal of Biological Chemistry. 275: 37150-8. PMID 10973948 DOI: 10.1074/Jbc.M001005200  0.496
2001 Branscombe TL, Frankel A, Lee JH, Cook JR, Yang ZH, Pestka S, Clarke S. PRMT5 (Janus Kinase-binding Protein 1) Catalyzes the Formation of Symmetric Dimethylarginine Residues in Proteins Journal of Biological Chemistry. 276: 32971-32976. DOI: 10.1074/Jbc.M105412200  0.639
2001 Young SG, Ambroziak P, Kim E, Clarke S. 7 Postisoprenylation protein processing: CXXX (CaaX) endoproteases and isoprenylcysteine carboxyl methyltransferase The Enzymes. 21: 155-213. DOI: 10.1016/S1874-6047(01)80020-2  0.453
2000 Thapar N, Clarke S. Expression, purification, and characterization of the protein repair l-isoaspartyl methyltransferase from Arabidopsis thaliana. Protein Expression and Purification. 20: 237-51. PMID 11049748 DOI: 10.1006/Prep.2000.1311  0.733
2000 Frankel A, Clarke S. PRMT3 is a distinct member of the protein arginine N-methyltransferase family: Conferral of substrate specificity by a zinc-finger domain Journal of Biological Chemistry. 275: 32974-32982. PMID 10931850 DOI: 10.1074/Jbc.M006445200  0.678
2000 Bedford MT, Frankel A, Yaffe MB, Clarke S, Leder P, Richard S. Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains. The Journal of Biological Chemistry. 275: 16030-6. PMID 10748127 DOI: 10.1074/Jbc.M909368199  0.6
2000 Tang J, Frankel A, Cook RJ, Kim S, Paik WK, Williams KR, Clarke S, Herschman HR. PRMT1 is the predominant type I protein arginine methyltransferase in mammalian cells. The Journal of Biological Chemistry. 275: 7723-30. PMID 10713084 DOI: 10.1074/Jbc.275.11.7723  0.676
1999 Kalhor HR, Niewmierzycka A, Faull KF, Yao X, Grade S, Clarke S, Rubenstein PA. A highly conserved 3-methylhistidine modification is absent in yeast actin. Archives of Biochemistry and Biophysics. 370: 105-11. PMID 10496983 DOI: 10.1006/Abbi.1999.1370  0.753
1999 DeVry CG, Clarke S. Polymorphic forms of the protein L-isoaspartate (D-aspartate) O-methyltrans-ferase involved in the repair of age-damaged proteins Journal of Human Genetics. 44: 275-288. PMID 10496068 DOI: 10.1007/S100380050161  0.384
1999 Kim E, Lowenson JD, Clarke S, Young SG. Phenotypic analysis of seizure-prone mice lacking L-isoaspartate (D-aspartate) O-methyltransferase. The Journal of Biological Chemistry. 274: 20671-8. PMID 10400700 DOI: 10.1074/Jbc.274.29.20671  0.391
1999 Frankel A, Clarke S. RNase treatment of yeast and mammalian cell extracts affects in vitro substrate methylation by Type I protein arginine N-methyltransferases Biochemical and Biophysical Research Communications. 259: 391-400. PMID 10362520 DOI: 10.1006/Bbrc.1999.0779  0.703
1999 Cai H, Clarke S. A novel methyltransferase catalyzes the methyl esterification of trans-aconitate in Escherichia coli. The Journal of Biological Chemistry. 274: 13470-9. PMID 10224113 DOI: 10.1074/Jbc.274.19.13470  0.443
1999 Niewmierzycka A, Clarke S. Do damaged proteins accumulate in Caenorhabditis elegans L-isoaspartate methyltransferase (pcm-1) deletion mutants? Archives of Biochemistry and Biophysics. 364: 209-18. PMID 10190976 DOI: 10.1006/Abbi.1999.1114  0.461
1999 Yan SD, Shi Y, Zhu A, Fu J, Zhu H, Zhu Y, Gibson L, Stern E, Collison K, Al-Mohanna F, Ogawa S, Roher A, Clarke SG, Stern DM. Role of ERAB/L-3-hydroxyacyl-coenzyme A dehydrogenase type II activity in Abeta-induced cytotoxicity. The Journal of Biological Chemistry. 274: 2145-56. PMID 9890977 DOI: 10.1074/Jbc.274.4.2145  0.351
1999 Niewmierzycka A, Clarke S. S-Adenosylmethionine-dependent methylation in Saccharomyces cerevisiae. Identification of a novel protein arginine methyltransferase. The Journal of Biological Chemistry. 274: 814-24. PMID 9873020 DOI: 10.1074/Jbc.274.2.814  0.537
1998 Zobel-Thropp P, Gary JD, Clarke S. delta-N-methylarginine is a novel posttranslational modification of arginine residues in yeast proteins. The Journal of Biological Chemistry. 273: 29283-6. PMID 9792625 DOI: 10.1074/Jbc.273.45.29283  0.503
1998 Visick JE, Ichikawa JK, Clarke S. Mutations in the Escherichia coli surE gene increase isoaspartyl accumulation in a strain lacking the pcm repair methyltransferase but suppress stress-survival phenotypes. Fems Microbiology Letters. 167: 19-25. PMID 9785447 DOI: 10.1111/J.1574-6968.1998.Tb13202.X  0.361
1998 Ichikawa JK, Clarke S. A highly active protein repair enzyme from an extreme thermophile: the L-isoaspartyl methyltransferase from Thermotoga maritima. Archives of Biochemistry and Biophysics. 358: 222-31. PMID 9784234 DOI: 10.1006/Abbi.1998.0830  0.494
1998 Gary JD, Clarke S. RNA and Protein Interactions Modulated by Protein Arginine Methylation Progress in Nucleic Acid Research and Molecular Biology. 61: 65-131. PMID 9752719 DOI: 10.1016/S0079-6603(08)60825-9  0.525
1998 Tang J, Gary JD, Clarke S, Herschman HR. PRMT 3, a type I protein arginine N-methyltransferase that differs from PRMT1 in its oligomerization, subcellular localization, substrate specificity, and regulation. The Journal of Biological Chemistry. 273: 16935-45. PMID 9642256 DOI: 10.1074/Jbc.273.27.16935  0.499
1998 Visick JE, Cai H, Clarke S. The L-isoaspartyl protein repair methyltransferase enhances survival of aging Escherichia coli subjected to secondary environmental stresses. Journal of Bacteriology. 180: 2623-9. PMID 9573145 DOI: 10.1128/Jb.180.10.2623-2629.1998  0.401
1998 Kagan RM, Niewmierzycka A, Clarke S. Targeted gene disruption of the Caenorhabditis elegans L-isoaspartyl protein repair methyltransferase impairs survival of dauer stage nematodes. Archives of Biochemistry and Biophysics. 348: 320-8. PMID 9434744 DOI: 10.1006/Abbi.1997.0362  0.494
1997 Mudgett MB, Lowenson JD, Clarke S. Protein repair L-isoaspartyl methyltransferase in plants. Phylogenetic distribution and the accumulation of substrate proteins in aged barley seeds. Plant Physiology. 115: 1481-9. PMID 9414558 DOI: 10.1104/Pp.115.4.1481  0.409
1997 David CL, Szumlanski CL, DeVry CG, Park-Hah JO, Clarke S, Weinshilboum RM, Aswad DW. Human erythrocyte protein L-isoaspartyl methyltransferase: heritability of basal activity and genetic polymorphism for thermal stability. Archives of Biochemistry and Biophysics. 346: 277-86. PMID 9343375 DOI: 10.1006/Abbi.1997.0303  0.638
1997 Kagan RM, McFadden HJ, McFadden PN, O'Connor C, Clarke S. Molecular phylogenetics of a protein repair methyltransferase Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology. 117: 379-385. PMID 9253175 DOI: 10.1016/S0305-0491(96)00333-1  0.47
1997 Visick JE, Clarke S. RpoS- and OxyR-independent induction of HPI catalase at stationary phase in Escherichia coli and identification of rpoS mutations in common laboratory strains. Journal of Bacteriology. 179: 4158-63. PMID 9209028 DOI: 10.1128/Jb.179.13.4158-4163.1997  0.317
1997 Kim E, Lowenson JD, MacLaren DC, Clarke S, Young SG. Deficiency of a protein-repair enzyme results in the accumulation of altered proteins, retardation of growth, and fatal seizures in mice. Proceedings of the National Academy of Sciences of the United States of America. 94: 6132-7. PMID 9177182 DOI: 10.1073/Pnas.94.12.6132  0.482
1996 Devry CG, Tsai W, Clarke S. Structure of the human gene encoding the protein repair L-isoaspartyl (D-aspartyl) O-methyltransferase. Archives of Biochemistry and Biophysics. 335: 321-332. PMID 8914929 DOI: 10.1006/Abbi.1996.0513  0.409
1996 Lin WJ, Gary JD, Yang MC, Clarke S, Herschman HR. The mammalian immediate-early TIS21 protein and the leukemia-associated BTG1 protein interact with a protein-arginine N-methyltransferase. The Journal of Biological Chemistry. 271: 15034-44. PMID 8663146 DOI: 10.1074/Jbc.271.25.15034  0.497
1996 MacLaren DC, Clarke S. Rapid mapping of genomic P1 clones: the mouse L-isoaspartyl/D-aspartyl methyltransferase gene. Genomics. 35: 299-307. PMID 8661142 DOI: 10.1006/Geno.1996.0360  0.348
1996 Gary JD, Lin WJ, Yang MC, Herschman HR, Clarke S. The predominant protein-arginine methyltransferase from Saccharomyces cerevisiae. The Journal of Biological Chemistry. 271: 12585-94. PMID 8647869 DOI: 10.1074/Jbc.271.21.12585  0.55
1996 Mudgett MB, Clarke S. A distinctly regulated protein repair L-isoaspartylmethyltransferase from Arabidopsis thaliana. Plant Molecular Biology. 30: 723-37. PMID 8624405 DOI: 10.1007/Bf00019007  0.498
1995 Gary JD, Clarke S. Purification and characterization of an isoaspartyl dipeptidase from Escherichia coli. The Journal of Biological Chemistry. 270: 4076-87. PMID 7876157 DOI: 10.1074/Jbc.270.8.4076  0.398
1995 MacLaren DC, Clarke S. Expression and purification of a human recombinant methyltransferase that repairs damaged proteins. Protein Expression and Purification. 6: 99-108. PMID 7756844 DOI: 10.1006/PREP.1995.1013  0.418
1995 Kagan RM, Clarke S. Protein L-isoaspartyl methyltransferase from the nematode Caenorhabditis elegans: genomic structure and substrate specificity. Biochemistry. 34: 10794-806. PMID 7662659 DOI: 10.1021/Bi00034A012  0.505
1995 Brennan TV, Clarke S. Effect of adjacent histidine and cysteine residues on the spontaneous degradation of asparaginyl- and aspartyl-containing peptides. International Journal of Peptide and Protein Research. 45: 547-53. PMID 7558585 DOI: 10.1111/J.1399-3011.1995.Tb01318.X  0.351
1995 Visick JE, Clarke S. Repair, refold, recycle: how bacteria can deal with spontaneous and environmental damage to proteins. Molecular Microbiology. 16: 835-45. PMID 7476182 DOI: 10.1111/J.1365-2958.1995.Tb02311.X  0.407
1995 Shen-Miller J, Mudgett MB, Schopf JW, Clarke S, Berger R. Exceptional seed longevity and robust growth: Ancient Sacred Lotus from China American Journal of Botany. 82: 1367-1380. DOI: 10.1002/J.1537-2197.1995.Tb12673.X  0.312
1994 Kagan RM, Clarke S. Widespread occurrence of three sequence motifs in diverse S-adenosylmethionine-dependent methyltransferases suggests a common structure for these enzymes. Archives of Biochemistry and Biophysics. 310: 417-27. PMID 8179327 DOI: 10.1006/Abbi.1994.1187  0.389
1994 Ichikawa JK, Li C, Fu J, Clarke S. A gene at 59 minutes on the Escherichia coli chromosome encodes a lipoprotein with unusual amino acid repeat sequences. Journal of Bacteriology. 176: 1630-8. PMID 8132457 DOI: 10.1128/Jb.176.6.1630-1638.1994  0.354
1994 Hrycyna CA, Yang MC, Clarke S. Protein carboxyl methylation in Saccharomyces cerevisiae: evidence for STE14-dependent and STE14-independent pathways. Biochemistry. 33: 9806-12. PMID 8068661 DOI: 10.1021/Bi00198A053  0.718
1994 Xie H, Clarke S. An enzymatic activity in bovine brain that catalyzes the reversal of the C-terminal methyl esterification of protein phosphatase 2A. Biochemical and Biophysical Research Communications. 203: 1710-5. PMID 7945320 DOI: 10.1006/BBRC.1994.2383  0.403
1994 Li C, Ichikawa JK, Ravetto JJ, Kuo HC, Fu JC, Clarke S. A new gene involved in stationary-phase survival located at 59 minutes on the Escherichia coli chromosome. Journal of Bacteriology. 176: 6015-22. PMID 7928962 DOI: 10.1128/Jb.176.19.6015-6022.1994  0.351
1993 Brennan TV, Clarke S. Spontaneous degradation of polypeptides at aspartyl and asparaginyl residues: effects of the solvent dielectric. Protein Science : a Publication of the Protein Society. 2: 331-8. PMID 8453372 DOI: 10.1002/Pro.5560020305  0.347
1993 Hrycyna CA, Clarke S. Modification of eukaryotic signaling proteins by C-terminal methylation reactions. Pharmacology & Therapeutics. 59: 281-300. PMID 8309992 DOI: 10.1016/0163-7258(93)90071-K  0.734
1993 Kujubu DA, Stimmel JB, Law RE, Herschman HR, Clarke S. Early responses of PC-12 cells to NGF and EGF: effect of K252a and 5'-methylthioadenosine on gene expression and membrane protein methylation. Journal of Neuroscience Research. 36: 58-65. PMID 8230321 DOI: 10.1002/Jnr.490360107  0.414
1993 Hrycyna CA, Clarke S. Purification and characterization of a novel metalloendopeptidase from Saccharomyces cerevisiae. Biochemistry. 32: 11293-301. PMID 8218194 DOI: 10.1021/Bi00093A005  0.686
1993 Mudgett MB, Clarke S. Characterization of plant L-isoaspartyl methyltransferases that may be involved in seed survival: purification, cloning, and sequence analysis of the wheat germ enzyme. Biochemistry. 32: 11100-11. PMID 8198620 DOI: 10.1021/Bi00092A020  0.466
1992 Ingrosso D, Clarke S. Human erythrocyte D-aspartyl/L-isoaspartyl methyltransferases: enzymes that recognize age-damaged proteins. Advances in Experimental Medicine and Biology. 307: 263-76. PMID 1805590 DOI: 10.1007/978-1-4684-5985-2_24  0.433
1992 Law RE, Stimmel JB, Damore MA, Carter C, Clarke S, Wall R. Lipopolysaccharide-induced NF-kappa B activation in mouse 70Z/3 pre-B lymphocytes is inhibited by mevinolin and 5'-methylthioadenosine: roles of protein isoprenylation and carboxyl methylation reactions. Molecular and Cellular Biology. 12: 103-111. PMID 1729592 DOI: 10.1128/Mcb.12.1.103  0.402
1992 Li C, Clarke S. Distribution of an L-isoaspartyl protein methyltransferase in eubacteria. Journal of Bacteriology. 174: 355-61. PMID 1729230 DOI: 10.1128/Jb.174.2.355-361.1992  0.483
1992 Clarke S. Protein isoprenylation and methylation at carboxyl-terminal cysteine residues Annual Review of Biochemistry. 61: 355-386. PMID 1497315 DOI: 10.1146/Annurev.Bi.61.070192.002035  0.495
1992 Li C, Clarke S. A protein methyltransferase specific for altered aspartyl residues is important in Escherichia coli stationary-phase survival and heat-shock resistance. Proceedings of the National Academy of Sciences of the United States of America. 89: 9885-9. PMID 1409717 DOI: 10.1073/Pnas.89.20.9885  0.476
1992 MacLaren DC, Kagan RM, Clarke S. Alternative splicing of the human isoaspartyl protein carboxyl methyltransferase RNA leads to the generation of a C-terminal -RDEL sequence in isozyme II. Biochemical and Biophysical Research Communications. 185: 277-83. PMID 1339271 DOI: 10.1016/S0006-291X(05)80987-8  0.37
1991 Hrycyna CA, Sapperstein SK, Clarke S, Michaelis S. The Saccharomyces cerevisiae STE14 gene encodes a methyltransferase that mediates C-terminal methylation of a-factor and RAS proteins. The Embo Journal. 10: 1699-709. PMID 2050108 DOI: 10.1002/J.1460-2075.1991.Tb07694.X  0.743
1991 Ingrosso D, Kagan RM, Clarke S. Distinct C-terminal sequences of isozymes I and II of the human erythrocyte L-isoaspartyl/D-aspartyl protein methyltransferase. Biochemical and Biophysical Research Communications. 175: 351-8. PMID 1998518 DOI: 10.1016/S0006-291X(05)81242-2  0.401
1991 Yamane HK, Farnsworth CC, Xie HY, Evans T, Howald WN, Gelb MH, Glomset JA, Clarke S, Fung BK. Membrane-binding domain of the small G protein G25K contains an S-(all-trans-geranylgeranyl)cysteine methyl ester at its carboxyl terminus. Proceedings of the National Academy of Sciences of the United States of America. 88: 286-90. PMID 1898776 DOI: 10.1073/Pnas.88.1.286  0.463
1991 Lowenson JD, Clarke S. Spontaneous degradation and enzymatic repair of aspartyl and asparaginyl residues in aging red cell proteins analyzed by computer simulation. Gerontology. 37: 128-51. PMID 1829049 DOI: 10.1159/000213255  0.519
1990 Stimmel JB, Deschenes RJ, Volker C, Stock J, Clarke S. Evidence for an S-farnesylcysteine methyl ester at the carboxyl terminus of the Saccharomyces cerevisiae RAS2 protein Biochemistry. 29: 9651-9659. PMID 2271607 DOI: 10.1021/Bi00493A021  0.5
1990 George-Nascimento C, Lowenson J, Borissenko M, Calderón M, Medina-Selby A, Kuo J, Clarke S, Randolph A. Replacement of a labile aspartyl residue increases the stability of human epidermal growth factor. Biochemistry. 29: 9584-91. PMID 2271602 DOI: 10.1021/Bi00493A012  0.41
1990 Hrycyna CA, Clarke S. Farnesyl cysteine C-terminal methyltransferase activity is dependent upon the STE14 gene product in Saccharomyces cerevisiae. Molecular and Cellular Biology. 10: 5071-6. PMID 2204804 DOI: 10.1128/Mcb.10.10.5071  0.718
1990 Ota IM, Clarke S. Multiple sites of methyl esterification of calmodulin in intact human erythrocytes. Archives of Biochemistry and Biophysics. 279: 320-7. PMID 2190534 DOI: 10.1016/0003-9861(90)90498-N  0.423
1990 Momand JA, Clarke S. The fidelity of protein synthesis: can mischarging by aspartyl-tRNA(Asp) synthetase lead to the formation of isoaspartyl residues in proteins? Biochimica Et Biophysica Acta. 1040: 153-8. PMID 2144770 DOI: 10.1016/0167-4838(90)90070-V  0.727
1990 Fung BK, Yamane HK, Ota IM, Clarke S. The gamma subunit of brain G-proteins is methyl esterified at a C-terminal cysteine. Febs Letters. 260: 313-7. PMID 2105241 DOI: 10.1016/0014-5793(90)80132-3  0.439
1990 Xie H, Yamane HK, Stephenson RC, Ong OC, Fung BK-, Clarke S. Analysis of prenylated carboxyl-terminal cysteine methyl esters in proteins Methods. 1: 276-282. DOI: 10.1016/S1046-2023(05)80328-7  0.435
1989 Clarke S, Smigel MD. Size and shape of membrane protein-detergent complexes: hydrodynamic studies. Methods in Enzymology. 172: 696-709. PMID 2747546 DOI: 10.1016/S0076-6879(89)72039-5  0.332
1989 Ingrosso D, Fowler AV, Bleibaum J, Clarke S. Specificity of endoproteinase Asp-N (Pseudomonas fragi): cleavage at glutamyl residues in two proteins. Biochemical and Biophysical Research Communications. 162: 1528-34. PMID 2669754 DOI: 10.1016/0006-291X(89)90848-6  0.416
1989 Ong OC, Ota IM, Clarke S, Fung BK. The membrane binding domain of rod cGMP phosphodiesterase is posttranslationally modified by methyl esterification at a C-terminal cysteine. Proceedings of the National Academy of Sciences of the United States of America. 86: 9238-42. PMID 2556707 DOI: 10.1073/Pnas.86.23.9238  0.442
1989 Ota IM, Clarke S. Calcium affects the spontaneous degradation of aspartyl/asparaginyl residues in calmodulin. Biochemistry. 28: 4020-7. PMID 2502176 DOI: 10.1021/Bi00435A058  0.424
1988 Momand J, Clarke S. Rapid degradation of D- and L-succinimide-containing peptides by a post-proline endopeptidase from human erythrocytes. Biochemistry. 26: 7798-805. PMID 3480758 DOI: 10.1021/Bi00398A040  0.74
1988 Ota IM, Gilbert JM, Clarke S. Two major isozymes of the protein D-aspartyl/L-isoaspartyl methyltransferase from human erythrocytes. Biochemical and Biophysical Research Communications. 151: 1136-43. PMID 3355545 DOI: 10.1016/S0006-291X(88)80484-4  0.42
1988 Clarke S, Vogel JP, Deschenes RJ, Stock J. Posttranslational modification of the Ha-ras oncogene protein: Evidence for a third class of protein carboxyl methyltransferases Proceedings of the National Academy of Sciences of the United States of America. 85: 4643-4647. PMID 3290900 DOI: 10.1073/Pnas.85.13.4643  0.672
1988 Gilbert JM, Fowler A, Bleibaum J, Clarke S. Purification of homologous protein carboxyl methyltransferase isozymes from human and bovine erythrocytes. Biochemistry. 27: 5227-33. PMID 3167043 DOI: 10.1021/Bi00414A042  0.412
1988 Clarke S. Perspectives on the biological function and enzymology of protein carboxyl methylation reactions in eucaryotic and procaryotic cells Advances in Experimental Medicine and Biology. 231: 213-228. PMID 3046247 DOI: 10.1007/978-1-4684-9042-8_17  0.466
1987 Lou LL, Clarke S. Enzymatic methylation of band 3 anion transporter in intact human erythrocytes Biochemistry. 26: 52-59. PMID 3828308 DOI: 10.1021/Bi00375A008  0.475
1987 Brunauer LS, Clarke S. Methylation of calmodulin at carboxylic acid residues in erythrocytes. A non-regulatory covalent modification? The Biochemical Journal. 236: 811-20. PMID 3790092 DOI: 10.1042/BJ2360811  0.36
1987 McFadden PN, Clarke S. Conversion of isoaspartyl peptides to normal peptides: Implications for the cellular repair of damaged proteins Proceedings of the National Academy of Sciences of the United States of America. 84: 2595-2599. PMID 3472227 DOI: 10.1073/Pnas.84.9.2595  0.441
1987 Clarke S. Propensity for spontaneous succinimide formation from aspartyl and asparaginyl residues in cellular proteins International Journal of Peptide and Protein Research. 30: 808-821. PMID 3440704 DOI: 10.1111/J.1399-3011.1987.Tb03390.X  0.38
1987 Stock A, Clarke S, Clarke C, Stock J. N-terminal methylation of proteins: structure, function and specificity. Febs Letters. 220: 8-14. PMID 3301412 DOI: 10.1016/0014-5793(87)80866-9  0.717
1987 McFadden PN, Lou LL, Drickamer K, Clarke S. The stereospecificity of protein kinases Archives of Biochemistry and Biophysics. 259: 227-233. PMID 2447831 DOI: 10.1016/0003-9861(87)90490-5  0.384
1986 McFadden PN, Clarke S. Protein carboxyl methyltransferase and methyl acceptor proteins in aging and cataractous tissue of the human eye lens Mechanisms of Ageing and Development. 34: 91-105. PMID 3713272 DOI: 10.1016/0047-6374(86)90107-7  0.475
1986 Barber JR, Morimoto BH, Brunauer LS, Clarke S. Metabolism of S-adenosyl-L-methionine in intact human erythrocytes. Biochimica Et Biophysica Acta. 886: 361-72. PMID 3011117 DOI: 10.1016/0167-4889(86)90171-0  0.399
1985 Barber JR, Clarke S. Demethylation of protein carboxyl methyl esters: A nonenzymatic process in human erythrocytes? Biochemistry. 24: 4867-4871. PMID 4074664 DOI: 10.1021/Bi00339A021  0.479
1985 O'Connor CM, Clarke S. Analysis of erythrocyte protein methyl esters by two-dimensional gel electrophoresis under acidic separating conditions Analytical Biochemistry. 148: 79-86. PMID 4037310 DOI: 10.1016/0003-2697(85)90630-X  0.484
1985 O'Connor CM, Clarke S. Specific recognition of altered polypeptides by widely distributed methyltransferases Biochemical and Biophysical Research Communications. 132: 1144-1150. PMID 3907631 DOI: 10.1016/0006-291X(85)91926-6  0.468
1985 Clarke S. Protein carboxyl methyltransferases: Two distinct classes of enzymes Annual Review of Biochemistry. 479-506. PMID 3896126 DOI: 10.1146/Annurev.Bi.54.070185.002403  0.527
1985 Valentine WN, Paglia DE, Clarke S, Morimoto BH, Nakatani M, Brockway R. Adenine ribo- and deoxyribonucleotide metabolism in human erythrocytes, B- and T-lymphocyte cell lines, and monocyte-macrophages. Proceedings of the National Academy of Sciences of the United States of America. 82: 6682-6. PMID 3863121 DOI: 10.1073/Pnas.82.19.6682  0.333
1985 Bates M, Weiss RL, Clarke S. Ornithine transcarbamylase from Neurospora crassa: purification and properties. Archives of Biochemistry and Biophysics. 239: 172-83. PMID 3159341 DOI: 10.1016/0003-9861(85)90824-0  0.321
1984 O'Connor CM, Aswad DW, Clarke S. Mammalian brain and erythrocyte carboxyl methyltransferases are similar enzymes that recognize both D-aspartyl and L-isoaspartyl residues in structurally altered protein substrates. Proceedings of the National Academy of Sciences of the United States of America. 81: 7757-61. PMID 6595658 DOI: 10.1073/Pnas.81.24.7757  0.727
1984 Barber JR, Clarke S. Membrane protein carboxyl methylation does not appear to be involved in the response of erythrocytes to cytoskeletal stress Biochemical and Biophysical Research Communications. 123: 133-140. PMID 6433913 DOI: 10.1016/0006-291X(84)90390-5  0.448
1984 Clarke S, McFadden PN, O'Connor CM, Lou LL. Isolation of D-aspartic acid beta-methyl ester from erythrocyte carboxyl methylated proteins. Methods in Enzymology. 106: 330-44. PMID 6387377 DOI: 10.1016/0076-6879(84)06033-X  0.432
1984 Stock JB, Clarke S, Koshland DE. The protein carboxylmethyltransferase involved in Escherichia coli and Salmonella typhimurium chemotaxis. Methods in Enzymology. 106: 310-21. PMID 6387375 DOI: 10.1016/0076-6879(84)06031-6  0.745
1983 Oden KL, Clarke S. S-adenosyl-L-methionine synthetase from human erythrocytes: role in the regulation of cellular S-adenosylmethionine levels. Biochemistry. 22: 2978-86. PMID 6871179 DOI: 10.1021/Bi00281A030  0.446
1983 McFadden PN, Horwitz J, Clarke S. Protein carboxyl methyltransferase from cow eye lens Biochemical and Biophysical Research Communications. 113: 418-424. PMID 6870865 DOI: 10.1016/0006-291X(83)91742-4  0.513
1983 Oden KL, Carson K, Mecham JO, Hoffman RM, Clarke S. S-adenosylmethionine synthetase in cultured normal and oncogenically-transformed human and rat cells. Biochimica Et Biophysica Acta. 760: 270-7. PMID 6313064 DOI: 10.1016/0304-4165(83)90173-3  0.331
1983 Clarke S, O'connor CM. Do eukaryotic carboxyl methyltransferase regulate protein function? Trends in Biochemical Sciences. 8: 391-394. DOI: 10.1016/0968-0004(83)90300-6  0.422
1982 McFadden PN, Clarke S. Methylation at D-aspartyl residues in erythrocytes: possible step in the repair of aged membrane proteins Proceedings of the National Academy of Sciences of the United States of America. 79: 2460-2464. PMID 6123997 DOI: 10.1073/PNAS.79.8.2460  0.392
1981 Clarke S. Direct renaturation of the dodecyl sulfate complexes of proteins with triton X-100 Bba - Protein Structure. 670: 195-202. PMID 7295774 DOI: 10.1016/0005-2795(81)90009-X  0.357
1980 Clarke S, Sparrow K, Panasenko S, Koshland DE. In vitro methylation of bacterial chemotaxis proteins: characterization of protein methyltransferase activity in crude extracts of Salmonella typhimurium. Journal of Supramolecular Structure. 13: 315-28. PMID 7009989 DOI: 10.1002/jss.400130305  0.596
1979 Clarke S, Koshland Jr. DE. The effect of protein modification reagents on the chemotactic response in Salmonella typhimurium Canadian Journal of Biochemistry. 57: 1332-1336. DOI: 10.1139/O79-177  0.358
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