☰

Weikang Cai, Ph.D. - Publications

Affiliations: 
2011 Biochemistry University of Kentucky, Lexington, KY 
Area:
Biochemistry
Tree Info Similar researchers PubMed Report error

54 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Wu L, Wang F, Moncman CL, Pandey M, Clarke HA, Frazier HN, Young LEA, Gentry MS, Cai W, Thibault O, Sun RC, Andres DA. RIT1 regulation of CNS lipids RIT1 deficiency Alters cerebral lipid metabolism and reduces white matter tract oligodendrocytes and conduction velocities. Heliyon. 9: e20384. PMID 37780758 DOI: 10.1016/j.heliyon.2023.e20384  0.526
2023 Moon S, Alsarkhi L, Lin TT, Inoue R, Tahiri A, Colson C, Cai W, Shirakawa J, Qian WJ, Zhao JY, El Ouaamari A. Transcriptome and secretome profiling of sensory neurons reveals sex differences in pathways relevant to insulin sensing and insulin secretion. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 37: e23185. PMID 37695721 DOI: 10.1096/fj.202300941R  0.314
2023 Chen W, Huang Q, Lazdon EK, Gomes A, Wong M, Stephens E, Royal TG, Frenkel D, Cai W, Kahn CR. Loss of insulin signaling in astrocytes exacerbates Alzheimer-like phenotypes in a 5xFAD mouse model. Proceedings of the National Academy of Sciences of the United States of America. 120: e2220684120. PMID 37186836 DOI: 10.1073/pnas.2220684120  0.662
2023 Nagao H, Jayavelu AK, Cai W, Pan H, Dreyfuss JM, Batista TM, Brandão BB, Mann M, Kahn CR. Unique ligand and kinase-independent roles of the insulin receptor in regulation of cell cycle, senescence and apoptosis. Nature Communications. 14: 57. PMID 36599833 DOI: 10.1038/s41467-022-35693-5  0.482
2022 Nagao H, Cai W, Brasil Brandão B, Wewer Albrechtsen NJ, Steger M, Gattu AK, Pan H, Dreyfuss JM, Wunderlich FT, Mann M, Kahn CR. Leucine-973 is a crucial residue differentiating insulin and IGF-1 receptor signaling. The Journal of Clinical Investigation. PMID 36548088 DOI: 10.1172/JCI161472  0.532
2022 Geffken SJ, Moon S, Smith CO, Tang S, Lee HH, Lewis K, Wong CW, Huang Y, Huang Q, Zhao YT, Cai W. Insulin and IGF-1 elicit robust transcriptional regulation to modulate autophagy in astrocytes. Molecular Metabolism. 66: 101647. PMID 36503893 DOI: 10.1016/j.molmet.2022.101647  0.409
2022 Sakaguchi M, Okagawa S, Okubo Y, Otsuka Y, Fukuda K, Igata M, Kondo T, Sato Y, Yoshizawa T, Fukuda T, Yamagata K, Cai W, Tseng YH, Sakaguchi N, Kahn CR, et al. Phosphatase protector alpha4 (α4) is involved in adipocyte maintenance and mitochondrial homeostasis through regulation of insulin signaling. Nature Communications. 13: 6092. PMID 36241662 DOI: 10.1038/s41467-022-33842-4  0.512
2022 Chen W, Cai W, Hoover B, Kahn CR. Insulin action in the brain: cell types, circuits, and diseases. Trends in Neurosciences. PMID 35361499 DOI: 10.1016/j.tins.2022.03.001  0.64
2021 Cai W, Zhang X, Batista TM, García-Martín R, Softic S, Wang G, Ramirez AK, Konishi M, O'Neill BT, Kim JH, Kim JK, Kahn CR. Peripheral Insulin Regulates a Broad Network of Gene Expression in the Hypothalamus, Hippocampus and Nucleus Accumbens. Diabetes. PMID 34031123 DOI: 10.2337/db20-1119  0.52
2021 Nagao H, Cai W, Wewer Albrechtsen NJ, Steger M, Batista TM, Pan H, Dreyfuss JM, Mann M, Kahn CR. Distinct signaling by insulin and IGF-1 receptors and their extra- and intracellular domains. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33879610 DOI: 10.1073/pnas.2019474118  0.514
2020 Wang G, Yu Y, Cai W, Batista TM, Suk S, Noh HL, Hirshman M, Nigro P, Li ME, Softic S, Goodyear L, Kim JK, Kahn CR. Muscle Specific Insulin Receptor Overexpression Protects Mice from Diet-Induced Glucose Intolerance but Leads to Post-Receptor Insulin Resistance. Diabetes. PMID 32868340 DOI: 10.2337/Db20-0439  0.568
2020 Ramirez AK, Dankel SN, Rastegarpanah B, Cai W, Xue R, Crovella M, Tseng YH, Kahn CR, Kasif S. Single-cell transcriptional networks in differentiating preadipocytes suggest drivers associated with tissue heterogeneity. Nature Communications. 11: 2117. PMID 32355218 DOI: 10.1038/S41467-020-16019-9  0.459
2020 Batista TM, Dagdeviren S, Carroll SH, Cai W, Melnik VY, Noh HL, Saengnipanthkul S, Kim JK, Kahn CR, Lee RT. Arrestin domain-containing 3 (Arrdc3) modulates insulin action and glucose metabolism in liver. Proceedings of the National Academy of Sciences of the United States of America. PMID 32156724 DOI: 10.1073/Pnas.1922370117  0.559
2020 Nagao H, Cai W, Batista TM, Pan H, Dreyfuss J, Kahn CR. 1737-P: Defining Distinct Actions of Insulin and IGF1 Receptors and Their Extra and Intracellular Domains at the Level of the Phosphoproteome Diabetes. 69. DOI: 10.2337/Db20-1737-P  0.516
2019 Li Q, Fu J, Xia Y, Qi W, Ishikado A, Park K, Yokomizo H, Huang Q, Cai W, Rask-Madsen C, Kahn CR, King GL. Homozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes. Nature Communications. 10: 4427. PMID 31562314 DOI: 10.1038/S41467-019-12368-2  0.567
2019 Li ME, Lauritzen HPMM, O'Neill BT, Wang CH, Cai W, Brandao BB, Sakaguchi M, Tao R, Hirshman MF, Softic S, Kahn CR. Role of p110a subunit of PI3-kinase in skeletal muscle mitochondrial homeostasis and metabolism. Nature Communications. 10: 3412. PMID 31363081 DOI: 10.1038/S41467-019-11265-Y  0.489
2019 Wang G, Meyer JG, Cai W, Softic S, Li ME, Verdin E, Newgard C, Schilling B, Kahn CR. Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation. Molecular Cell. PMID 31000437 DOI: 10.1016/J.Molcel.2019.03.021  0.594
2019 Sakaguchi M, Cai W, Wang CH, Cederquist CT, Damasio M, Homan EP, Batista T, Ramirez AK, Gupta MK, Steger M, Wewer Albrechtsen NJ, Singh SK, Araki E, Mann M, Enerbäck S, et al. FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism. Nature Communications. 10: 1582. PMID 30952843 DOI: 10.1038/S41467-019-09418-0  0.584
2019 Batista TM, Garcia-Martin R, Cai W, Konishi M, O'Neill BT, Sakaguchi M, Kim JH, Jung DY, Kim JK, Kahn CR. Multi-dimensional Transcriptional Remodeling by Physiological Insulin In Vivo. Cell Reports. 26: 3429-3443.e3. PMID 30893613 DOI: 10.1016/J.Celrep.2019.02.081  0.577
2019 Ramirez AK, Dankel S, Cai W, Sakaguchi M, Kasif S, Kahn CR. Membrane metallo-endopeptidase (Neprilysin) regulates inflammatory response and insulin signaling in white preadipocytes. Molecular Metabolism. PMID 30795914 DOI: 10.1016/J.Molmet.2019.01.006  0.516
2019 Soto M, Cai W, Konishi M, Kahn CR. Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior. Proceedings of the National Academy of Sciences of the United States of America. PMID 30765523 DOI: 10.1073/Pnas.1817391116  0.583
2019 Wardelmann K, Blümel S, Rath M, Alfine E, Chudoba C, Schell M, Cai W, Hauffe R, Warnke K, Flore T, Ritter K, Weiß J, Kahn CR, Kleinridders A. Insulin action in the brain regulates mitochondrial stress responses and reduces diet-induced weight gain. Molecular Metabolism. PMID 30670351 DOI: 10.1016/J.Molmet.2019.01.001  0.542
2019 BATISTA TM, CAI W, BRANDAO B, KAHN CR. 35-OR: Physiological Insulin Regulates Alternative mRNA Splicing in Liver and Muscle at Multiple Levels Diabetes. 68: 35-OR. DOI: 10.2337/Db19-35-Or  0.577
2019 BRANDAO B, LI ME, CAI W, BATISTA TM, HIRSHMAN MF, GOODYEAR LJ, KAHN CR. 291-OR: Exercise Modulates Glucose Metabolism in Part through Changes in the Gut Microbiome Diabetes. 68: 291-OR. DOI: 10.2337/Db19-291-Or  0.464
2019 CAI W, BATISTA TM, MARTIN RG, RAMIREZ A, KONISHI M, BRIAN T. O, KIM JK, KAHN CR. 1805-P: Insulin Regulates a Broad Network of Gene Expression in the Brain to Regulated Brain Metabolism and Neurotransmission Diabetes. 68: 1805-P. DOI: 10.2337/Db19-1805-P  0.56
2019 WANG G, CAI W, BATISTA TM, SOFTIC S, KAHN CR. 1785-P: Mice with Muscle-Specific Insulin Receptor Overexpression Are Protected from Diet-Induced Obesity and Glucose Intolerance but Develop Post-Receptor Insulin Resistance Diabetes. 68: 1785-P. DOI: 10.2337/Db19-1785-P  0.575
2018 Bou Karam J, Cai W, Mohamed R, Huang T, Meng L, Homan EP, Dirice E, Kahn CR, El Ouaamari A. TRPV1 neurons regulate β-cell function in a sex-dependent manner. Molecular Metabolism. 18: 60-67. PMID 30473098 DOI: 10.1016/J.Molmet.2018.10.002  0.472
2018 Cai W, Xue C, Sakaguchi M, Konishi M, Shirazian A, Ferris HA, Li M, Yu R, Kleinridders A, Pothos EN, Kahn CR. Insulin regulates astrocyte gliotransmission and modulates behavior. The Journal of Clinical Investigation. PMID 29664737 DOI: 10.1172/Jci99366  0.566
2018 Altindis E, Cai W, Sakaguchi M, Zhang F, GuoXiao W, Liu F, De Meyts P, Gelfanov V, Pan H, DiMarchi R, Kahn CR. Viral insulin-like peptides activate human insulin and IGF-1 receptor signaling: A paradigm shift for host-microbe interactions. Proceedings of the National Academy of Sciences of the United States of America. PMID 29467286 DOI: 10.1073/Pnas.1721117115  0.548
2018 SAKAGUCHI M, CAI W, WANG C, BATISTA TM, ARAKI E, KAHN CR. FoxK1/K2 Are New, Important Components of IR and IGF1R Signaling and Control of Cell Proliferation and Metabolism Diabetes. 67: 356-OR. DOI: 10.2337/Db18-356-Or  0.561
2018 WANG G, MEYER JG, CAI W, LI ME, SOFTIC S, KAHN CR. Sirt5 Plays a Critical Role in Mitochondrial Protein Acylation and Mitochondrial Metabolic Homeostasis in Brown Fat Diabetes. 67: 274-OR. DOI: 10.2337/Db18-274-Or  0.489
2018 YUCHI Y, CAI W, TAKAGI T, PAN H, DREYFUSS J, FOSTER K, VERNON AH, SIMONSON DC, GOLDFINE A, HOEFLICH A, PATTI ME. IGFBP2 Is Increased after Gastric Bypass in Humans—Potential Impact on Hepatic Metabolism Diabetes. 67: 1833-P. DOI: 10.2337/Db18-1833-P  0.323
2018 CAI W, RAMIREZ A, DREYFUSS J, BATISTA TM, MARTIN RG, PAN H, LI ME, O'NEILL BT, KIM JK, RONALD KAHN C. Insulin Acutely Regulates Gene Expression in Brain–A New Potential Major Level of Control of Metabolism and Neurotransmission Diabetes. 67: 1792-P. DOI: 10.2337/Db18-1792-P  0.465
2018 BATISTA TM, MARTIN RG, CAI W, SUK S, NOH HL, KIM JK, RONALD KAHN C. Dissection of Insulin-Dependent Pathways in Skeletal Muscle under Physiological and Diabetic Conditions Diabetes. 67: 1785-P. DOI: 10.2337/Db18-1785-P  0.472
2017 Konishi M, Sakaguchi M, Lockhart SM, Cai W, Li ME, Homan EP, Rask-Madsen C, Kahn CR. Endothelial insulin receptors differentially control insulin signaling kinetics in peripheral tissues and brain of mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 28923931 DOI: 10.1073/Pnas.1710625114  0.571
2017 Mir S, Cai W, Carlson SW, Saatman KE, Andres DA. IGF-1 mediated Neurogenesis Involves a Novel RIT1/Akt/Sox2 Cascade. Scientific Reports. 7: 3283. PMID 28607354 DOI: 10.1038/S41598-017-03641-9  0.689
2017 Cai W, Sakaguchi M, Kleinridders A, Gonzalez-Del Pino G, Dreyfuss JM, O'Neill BT, Ramirez AK, Pan H, Winnay JN, Boucher J, Eck MJ, Kahn CR. Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression. Nature Communications. 8: 14892. PMID 28345670 DOI: 10.1038/Ncomms14892  0.532
2017 Sakaguchi M, Fujisaka S, Cai W, Winnay JN, Konishi M, O'Neill BT, Li M, García-Martín R, Takahashi H, Hu J, Kulkarni RN, Kahn CR. Adipocyte Dynamics and Reversible Metabolic Syndrome in Mice with an Inducible Adipocyte-Specific Deletion of the Insulin Receptor. Cell Metabolism. PMID 28065828 DOI: 10.1016/J.Cmet.2016.12.008  0.563
2016 Mir S, Cai W, Andres DA. RIT1 GTPase Regulates Sox2 Transcriptional Activity and Hippocampal Neurogenesis. The Journal of Biological Chemistry. PMID 28007959 DOI: 10.1074/Jbc.M116.749770  0.614
2016 O'Neill BT, Lee KY, Klaus K, Softic S, Krumpoch MT, Fentz J, Stanford KI, Robinson MM, Cai W, Kleinridders A, Pereira RO, Hirshman MF, Abel ED, Accili D, Goodyear LJ, et al. Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis. The Journal of Clinical Investigation. PMID 27525440 DOI: 10.1172/Jci86522  0.506
2016 García-Cáceres C, Quarta C, Varela L, Gao Y, Gruber T, Legutko B, Jastroch M, Johansson P, Ninkovic J, Yi CX, Le Thuc O, Szigeti-Buck K, Cai W, Meyer CW, Pfluger PT, et al. Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability. Cell. 166: 867-80. PMID 27518562 DOI: 10.1016/J.Cell.2016.07.028  0.553
2015 Kleinridders A, Cai W, Cappellucci L, Ghazarian A, Collins WR, Vienberg SG, Pothos EN, Kahn CR. Insulin resistance in brain alters dopamine turnover and causes behavioral disorders. Proceedings of the National Academy of Sciences of the United States of America. 112: 3463-8. PMID 25733901 DOI: 10.1073/Pnas.1500877112  0.54
2014 Cai W, Andres DA. mTORC2 is required for rit-mediated oxidative stress resistance. Plos One. 9: e115602. PMID 25531880 DOI: 10.1371/Journal.Pone.0115602  0.634
2014 Kleinridders A, Ferris HA, Cai W, Kahn CR. Insulin action in brain regulates systemic metabolism and brain function. Diabetes. 63: 2232-43. PMID 24931034 DOI: 10.2337/Db14-0568  0.584
2013 Cai W, Shi GX, Andres DA. Putting the Rit in cellular resistance: Rit, p38 MAPK and oxidative stress. Communicative & Integrative Biology. 6: e22297. PMID 23802035 DOI: 10.4161/Cib.22297  0.646
2013 Shi GX, Cai W, Andres DA. Rit subfamily small GTPases: regulators in neuronal differentiation and survival. Cellular Signalling. 25: 2060-8. PMID 23770287 DOI: 10.1016/J.Cellsig.2013.06.002  0.628
2012 Cai W, Rudolph JL, Sengoku T, Andres DA. Rit GTPase regulates a p38 MAPK-dependent neuronal survival pathway. Neuroscience Letters. 531: 125-30. PMID 23123784 DOI: 10.1016/J.Neulet.2012.10.036  0.649
2012 Shi GX, Cai W, Andres DA. Rit-mediated stress resistance involves a p38-mitogen- and stress-activated protein kinase 1 (MSK1)-dependent cAMP response element-binding protein (CREB) activation cascade. The Journal of Biological Chemistry. 287: 39859-68. PMID 23038261 DOI: 10.1074/Jbc.M112.384248  0.642
2012 Magyar J, Kiper CE, Sievert G, Cai W, Shi GX, Crump SM, Li L, Niederer S, Smith N, Andres DA, Satin J. Rem-GTPase regulates cardiac myocyte L-type calcium current. Channels (Austin, Tex.). 6: 166-73. PMID 22854599 DOI: 10.4161/Chan.20192  0.565
2012 Cai W, Carlson SW, Brelsfoard JM, Mannon CE, Moncman CL, Saatman KE, Andres DA. Rit GTPase signaling promotes immature hippocampal neuronal survival. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 9887-97. PMID 22815504 DOI: 10.1523/Jneurosci.0375-12.2012  0.602
2012 Gunton JE, Sisavanh M, Stokes RA, Satin J, Satin LS, Zhang M, Liu SM, Cai W, Cheng K, Cooney GJ, Laybutt DR, So T, Molero JC, Grey ST, Andres DA, et al. Mice deficient in GEM GTPase show abnormal glucose homeostasis due to defects in beta-cell calcium handling. Plos One. 7: e39462. PMID 22761801 DOI: 10.1371/Journal.Pone.0039462  0.657
2011 Cai W, Rudolph JL, Harrison SM, Jin L, Frantz AL, Harrison DA, Andres DA. An evolutionarily conserved Rit GTPase-p38 MAPK signaling pathway mediates oxidative stress resistance. Molecular Biology of the Cell. 22: 3231-41. PMID 21737674 DOI: 10.1091/Mbc.E11-05-0400  0.65
2011 Shi GX, Andres DA, Cai W. Ras family small GTPase-mediated neuroprotective signaling in stroke. Central Nervous System Agents in Medicinal Chemistry. 11: 114-37. PMID 21521171 DOI: 10.2174/187152411796011349  0.615
2007 Cai W, Shi G, Rudolph JL, Andres DA. TrkA‐mediated Activation of the Rit GTPase The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A617-A  0.545
Show low-probability matches.