| Year |
Citation |
Score |
| 2025 |
Yu Y, Wang G, Chen W, Liu X, Munoz VR, Cai W, Gomes AS, Kahn CR. Lrtm1 - A Novel Sensor of Insulin Signaling and Regulator of Metabolism and Activity. Diabetes. PMID 39919204 DOI: 10.2337/db24-1031 |
0.68 |
|
| 2024 |
Huang Q, Lee HH, Volpe B, Zhang Q, Xue C, Liu BC, Abuhasan YR, Li L, Yang JS, Egholm J, Gutierrez-Vazquez C, Li A, Lee A, Tang S, Wong CW, ... ... Cai W, et al. Deletion of murine astrocytic vesicular nucleotide transporter increases anxiety and depressive-like behavior and attenuates motivation for reward. Molecular Psychiatry. PMID 39122778 DOI: 10.1038/s41380-024-02692-5 |
0.367 |
|
| 2023 |
Wu L, Wang F, Moncman CL, Pandey M, Clarke HA, Frazier HN, Young LEA, Gentry MS, Cai W, Thibault O, Sun RC, Andres DA. RIT1 regulation of CNS lipids RIT1 deficiency Alters cerebral lipid metabolism and reduces white matter tract oligodendrocytes and conduction velocities. Heliyon. 9: e20384. PMID 37780758 DOI: 10.1016/j.heliyon.2023.e20384 |
0.527 |
|
| 2023 |
Moon S, Alsarkhi L, Lin TT, Inoue R, Tahiri A, Colson C, Cai W, Shirakawa J, Qian WJ, Zhao JY, El Ouaamari A. Transcriptome and secretome profiling of sensory neurons reveals sex differences in pathways relevant to insulin sensing and insulin secretion. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 37: e23185. PMID 37695721 DOI: 10.1096/fj.202300941R |
0.317 |
|
| 2023 |
Chen W, Huang Q, Lazdon EK, Gomes A, Wong M, Stephens E, Royal TG, Frenkel D, Cai W, Kahn CR. Loss of insulin signaling in astrocytes exacerbates Alzheimer-like phenotypes in a 5xFAD mouse model. Proceedings of the National Academy of Sciences of the United States of America. 120: e2220684120. PMID 37186836 DOI: 10.1073/pnas.2220684120 |
0.661 |
|
| 2023 |
Nagao H, Jayavelu AK, Cai W, Pan H, Dreyfuss JM, Batista TM, Brandão BB, Mann M, Kahn CR. Unique ligand and kinase-independent roles of the insulin receptor in regulation of cell cycle, senescence and apoptosis. Nature Communications. 14: 57. PMID 36599833 DOI: 10.1038/s41467-022-35693-5 |
0.483 |
|
| 2022 |
Nagao H, Cai W, Brasil Brandão B, Wewer Albrechtsen NJ, Steger M, Gattu AK, Pan H, Dreyfuss JM, Wunderlich FT, Mann M, Kahn CR. Leucine-973 is a crucial residue differentiating insulin and IGF-1 receptor signaling. The Journal of Clinical Investigation. PMID 36548088 DOI: 10.1172/JCI161472 |
0.537 |
|
| 2022 |
Geffken SJ, Moon S, Smith CO, Tang S, Lee HH, Lewis K, Wong CW, Huang Y, Huang Q, Zhao YT, Cai W. Insulin and IGF-1 elicit robust transcriptional regulation to modulate autophagy in astrocytes. Molecular Metabolism. 66: 101647. PMID 36503893 DOI: 10.1016/j.molmet.2022.101647 |
0.417 |
|
| 2022 |
Sakaguchi M, Okagawa S, Okubo Y, Otsuka Y, Fukuda K, Igata M, Kondo T, Sato Y, Yoshizawa T, Fukuda T, Yamagata K, Cai W, Tseng YH, Sakaguchi N, Kahn CR, et al. Phosphatase protector alpha4 (α4) is involved in adipocyte maintenance and mitochondrial homeostasis through regulation of insulin signaling. Nature Communications. 13: 6092. PMID 36241662 DOI: 10.1038/s41467-022-33842-4 |
0.516 |
|
| 2022 |
Chen W, Cai W, Hoover B, Kahn CR. Insulin action in the brain: cell types, circuits, and diseases. Trends in Neurosciences. PMID 35361499 DOI: 10.1016/j.tins.2022.03.001 |
0.638 |
|
| 2021 |
He X, Liu C, Peng J, Li Z, Li F, Wang J, Hu A, Peng M, Huang K, Fan D, Li N, Zhang F, Cai W, Tan X, Hu Z, ... ... Cai W, et al. COVID-19 induces new-onset insulin resistance and lipid metabolic dysregulation via regulation of secreted metabolic factors. Signal Transduction and Targeted Therapy. 6: 427. PMID 34916489 DOI: 10.1038/s41392-021-00822-x |
0.302 |
|
| 2021 |
Cai W, Zhang X, Batista TM, García-Martín R, Softic S, Wang G, Ramirez AK, Konishi M, O'Neill BT, Kim JH, Kim JK, Kahn CR. Peripheral Insulin Regulates a Broad Network of Gene Expression in the Hypothalamus, Hippocampus and Nucleus Accumbens. Diabetes. PMID 34031123 DOI: 10.2337/db20-1119 |
0.524 |
|
| 2021 |
Nagao H, Cai W, Wewer Albrechtsen NJ, Steger M, Batista TM, Pan H, Dreyfuss JM, Mann M, Kahn CR. Distinct signaling by insulin and IGF-1 receptors and their extra- and intracellular domains. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33879610 DOI: 10.1073/pnas.2019474118 |
0.516 |
|
| 2020 |
Wang G, Yu Y, Cai W, Batista TM, Suk S, Noh HL, Hirshman M, Nigro P, Li ME, Softic S, Goodyear L, Kim JK, Kahn CR. Muscle Specific Insulin Receptor Overexpression Protects Mice from Diet-Induced Glucose Intolerance but Leads to Post-Receptor Insulin Resistance. Diabetes. PMID 32868340 DOI: 10.2337/Db20-0439 |
0.575 |
|
| 2020 |
Ramirez AK, Dankel SN, Rastegarpanah B, Cai W, Xue R, Crovella M, Tseng YH, Kahn CR, Kasif S. Single-cell transcriptional networks in differentiating preadipocytes suggest drivers associated with tissue heterogeneity. Nature Communications. 11: 2117. PMID 32355218 DOI: 10.1038/S41467-020-16019-9 |
0.459 |
|
| 2020 |
Batista TM, Dagdeviren S, Carroll SH, Cai W, Melnik VY, Noh HL, Saengnipanthkul S, Kim JK, Kahn CR, Lee RT. Arrestin domain-containing 3 (Arrdc3) modulates insulin action and glucose metabolism in liver. Proceedings of the National Academy of Sciences of the United States of America. PMID 32156724 DOI: 10.1073/Pnas.1922370117 |
0.564 |
|
| 2020 |
Nagao H, Cai W, Batista TM, Pan H, Dreyfuss J, Kahn CR. 1737-P: Defining Distinct Actions of Insulin and IGF1 Receptors and Their Extra and Intracellular Domains at the Level of the Phosphoproteome Diabetes. 69. DOI: 10.2337/Db20-1737-P |
0.519 |
|
| 2019 |
Li Q, Fu J, Xia Y, Qi W, Ishikado A, Park K, Yokomizo H, Huang Q, Cai W, Rask-Madsen C, Kahn CR, King GL. Homozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes. Nature Communications. 10: 4427. PMID 31562314 DOI: 10.1038/S41467-019-12368-2 |
0.572 |
|
| 2019 |
Li ME, Lauritzen HPMM, O'Neill BT, Wang CH, Cai W, Brandao BB, Sakaguchi M, Tao R, Hirshman MF, Softic S, Kahn CR. Role of p110a subunit of PI3-kinase in skeletal muscle mitochondrial homeostasis and metabolism. Nature Communications. 10: 3412. PMID 31363081 DOI: 10.1038/S41467-019-11265-Y |
0.493 |
|
| 2019 |
Wang G, Meyer JG, Cai W, Softic S, Li ME, Verdin E, Newgard C, Schilling B, Kahn CR. Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation. Molecular Cell. PMID 31000437 DOI: 10.1016/J.Molcel.2019.03.021 |
0.594 |
|
| 2019 |
Sakaguchi M, Cai W, Wang CH, Cederquist CT, Damasio M, Homan EP, Batista T, Ramirez AK, Gupta MK, Steger M, Wewer Albrechtsen NJ, Singh SK, Araki E, Mann M, Enerbäck S, et al. FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism. Nature Communications. 10: 1582. PMID 30952843 DOI: 10.1038/S41467-019-09418-0 |
0.587 |
|
| 2019 |
Batista TM, Garcia-Martin R, Cai W, Konishi M, O'Neill BT, Sakaguchi M, Kim JH, Jung DY, Kim JK, Kahn CR. Multi-dimensional Transcriptional Remodeling by Physiological Insulin In Vivo. Cell Reports. 26: 3429-3443.e3. PMID 30893613 DOI: 10.1016/J.Celrep.2019.02.081 |
0.581 |
|
| 2019 |
Ramirez AK, Dankel S, Cai W, Sakaguchi M, Kasif S, Kahn CR. Membrane metallo-endopeptidase (Neprilysin) regulates inflammatory response and insulin signaling in white preadipocytes. Molecular Metabolism. PMID 30795914 DOI: 10.1016/J.Molmet.2019.01.006 |
0.52 |
|
| 2019 |
Soto M, Cai W, Konishi M, Kahn CR. Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior. Proceedings of the National Academy of Sciences of the United States of America. PMID 30765523 DOI: 10.1073/Pnas.1817391116 |
0.589 |
|
| 2019 |
Wardelmann K, Blümel S, Rath M, Alfine E, Chudoba C, Schell M, Cai W, Hauffe R, Warnke K, Flore T, Ritter K, Weiß J, Kahn CR, Kleinridders A. Insulin action in the brain regulates mitochondrial stress responses and reduces diet-induced weight gain. Molecular Metabolism. PMID 30670351 DOI: 10.1016/J.Molmet.2019.01.001 |
0.545 |
|
| 2019 |
BATISTA TM, CAI W, BRANDAO B, KAHN CR. 35-OR: Physiological Insulin Regulates Alternative mRNA Splicing in Liver and Muscle at Multiple Levels Diabetes. 68: 35-OR. DOI: 10.2337/Db19-35-Or |
0.581 |
|
| 2019 |
BRANDAO B, LI ME, CAI W, BATISTA TM, HIRSHMAN MF, GOODYEAR LJ, KAHN CR. 291-OR: Exercise Modulates Glucose Metabolism in Part through Changes in the Gut Microbiome Diabetes. 68: 291-OR. DOI: 10.2337/Db19-291-Or |
0.468 |
|
| 2019 |
CAI W, BATISTA TM, MARTIN RG, RAMIREZ A, KONISHI M, BRIAN T. O, KIM JK, KAHN CR. 1805-P: Insulin Regulates a Broad Network of Gene Expression in the Brain to Regulated Brain Metabolism and Neurotransmission Diabetes. 68: 1805-P. DOI: 10.2337/Db19-1805-P |
0.563 |
|
| 2019 |
WANG G, CAI W, BATISTA TM, SOFTIC S, KAHN CR. 1785-P: Mice with Muscle-Specific Insulin Receptor Overexpression Are Protected from Diet-Induced Obesity and Glucose Intolerance but Develop Post-Receptor Insulin Resistance Diabetes. 68: 1785-P. DOI: 10.2337/Db19-1785-P |
0.58 |
|
| 2018 |
Bou Karam J, Cai W, Mohamed R, Huang T, Meng L, Homan EP, Dirice E, Kahn CR, El Ouaamari A. TRPV1 neurons regulate β-cell function in a sex-dependent manner. Molecular Metabolism. 18: 60-67. PMID 30473098 DOI: 10.1016/J.Molmet.2018.10.002 |
0.472 |
|
| 2018 |
Cai W, Xue C, Sakaguchi M, Konishi M, Shirazian A, Ferris HA, Li M, Yu R, Kleinridders A, Pothos EN, Kahn CR. Insulin regulates astrocyte gliotransmission and modulates behavior. The Journal of Clinical Investigation. PMID 29664737 DOI: 10.1172/Jci99366 |
0.572 |
|
| 2018 |
Altindis E, Cai W, Sakaguchi M, Zhang F, GuoXiao W, Liu F, De Meyts P, Gelfanov V, Pan H, DiMarchi R, Kahn CR. Viral insulin-like peptides activate human insulin and IGF-1 receptor signaling: A paradigm shift for host-microbe interactions. Proceedings of the National Academy of Sciences of the United States of America. PMID 29467286 DOI: 10.1073/Pnas.1721117115 |
0.552 |
|
| 2018 |
SAKAGUCHI M, CAI W, WANG C, BATISTA TM, ARAKI E, KAHN CR. FoxK1/K2 Are New, Important Components of IR and IGF1R Signaling and Control of Cell Proliferation and Metabolism Diabetes. 67: 356-OR. DOI: 10.2337/Db18-356-Or |
0.563 |
|
| 2018 |
WANG G, MEYER JG, CAI W, LI ME, SOFTIC S, KAHN CR. Sirt5 Plays a Critical Role in Mitochondrial Protein Acylation and Mitochondrial Metabolic Homeostasis in Brown Fat Diabetes. 67: 274-OR. DOI: 10.2337/Db18-274-Or |
0.49 |
|
| 2018 |
YUCHI Y, CAI W, TAKAGI T, PAN H, DREYFUSS J, FOSTER K, VERNON AH, SIMONSON DC, GOLDFINE A, HOEFLICH A, PATTI ME. IGFBP2 Is Increased after Gastric Bypass in Humans—Potential Impact on Hepatic Metabolism Diabetes. 67: 1833-P. DOI: 10.2337/Db18-1833-P |
0.324 |
|
| 2018 |
CAI W, RAMIREZ A, DREYFUSS J, BATISTA TM, MARTIN RG, PAN H, LI ME, O'NEILL BT, KIM JK, RONALD KAHN C. Insulin Acutely Regulates Gene Expression in Brain–A New Potential Major Level of Control of Metabolism and Neurotransmission Diabetes. 67: 1792-P. DOI: 10.2337/Db18-1792-P |
0.47 |
|
| 2018 |
BATISTA TM, MARTIN RG, CAI W, SUK S, NOH HL, KIM JK, RONALD KAHN C. Dissection of Insulin-Dependent Pathways in Skeletal Muscle under Physiological and Diabetic Conditions Diabetes. 67: 1785-P. DOI: 10.2337/Db18-1785-P |
0.478 |
|
| 2017 |
Konishi M, Sakaguchi M, Lockhart SM, Cai W, Li ME, Homan EP, Rask-Madsen C, Kahn CR. Endothelial insulin receptors differentially control insulin signaling kinetics in peripheral tissues and brain of mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 28923931 DOI: 10.1073/Pnas.1710625114 |
0.576 |
|
| 2017 |
Mir S, Cai W, Carlson SW, Saatman KE, Andres DA. IGF-1 mediated Neurogenesis Involves a Novel RIT1/Akt/Sox2 Cascade. Scientific Reports. 7: 3283. PMID 28607354 DOI: 10.1038/S41598-017-03641-9 |
0.688 |
|
| 2017 |
Cai W, Sakaguchi M, Kleinridders A, Gonzalez-Del Pino G, Dreyfuss JM, O'Neill BT, Ramirez AK, Pan H, Winnay JN, Boucher J, Eck MJ, Kahn CR. Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression. Nature Communications. 8: 14892. PMID 28345670 DOI: 10.1038/Ncomms14892 |
0.535 |
|
| 2017 |
Sakaguchi M, Fujisaka S, Cai W, Winnay JN, Konishi M, O'Neill BT, Li M, García-Martín R, Takahashi H, Hu J, Kulkarni RN, Kahn CR. Adipocyte Dynamics and Reversible Metabolic Syndrome in Mice with an Inducible Adipocyte-Specific Deletion of the Insulin Receptor. Cell Metabolism. PMID 28065828 DOI: 10.1016/J.Cmet.2016.12.008 |
0.568 |
|
| 2016 |
Mir S, Cai W, Andres DA. RIT1 GTPase Regulates Sox2 Transcriptional Activity and Hippocampal Neurogenesis. The Journal of Biological Chemistry. PMID 28007959 DOI: 10.1074/Jbc.M116.749770 |
0.612 |
|
| 2016 |
O'Neill BT, Lee KY, Klaus K, Softic S, Krumpoch MT, Fentz J, Stanford KI, Robinson MM, Cai W, Kleinridders A, Pereira RO, Hirshman MF, Abel ED, Accili D, Goodyear LJ, et al. Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis. The Journal of Clinical Investigation. PMID 27525440 DOI: 10.1172/Jci86522 |
0.51 |
|
| 2016 |
García-Cáceres C, Quarta C, Varela L, Gao Y, Gruber T, Legutko B, Jastroch M, Johansson P, Ninkovic J, Yi CX, Le Thuc O, Szigeti-Buck K, Cai W, Meyer CW, Pfluger PT, et al. Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability. Cell. 166: 867-80. PMID 27518562 DOI: 10.1016/J.Cell.2016.07.028 |
0.559 |
|
| 2015 |
Kleinridders A, Cai W, Cappellucci L, Ghazarian A, Collins WR, Vienberg SG, Pothos EN, Kahn CR. Insulin resistance in brain alters dopamine turnover and causes behavioral disorders. Proceedings of the National Academy of Sciences of the United States of America. 112: 3463-8. PMID 25733901 DOI: 10.1073/Pnas.1500877112 |
0.544 |
|
| 2014 |
Cai W, Andres DA. mTORC2 is required for rit-mediated oxidative stress resistance. Plos One. 9: e115602. PMID 25531880 DOI: 10.1371/Journal.Pone.0115602 |
0.632 |
|
| 2014 |
Kleinridders A, Ferris HA, Cai W, Kahn CR. Insulin action in brain regulates systemic metabolism and brain function. Diabetes. 63: 2232-43. PMID 24931034 DOI: 10.2337/Db14-0568 |
0.589 |
|
| 2013 |
Cai W, Shi GX, Andres DA. Putting the Rit in cellular resistance: Rit, p38 MAPK and oxidative stress. Communicative & Integrative Biology. 6: e22297. PMID 23802035 DOI: 10.4161/Cib.22297 |
0.644 |
|
| 2013 |
Shi GX, Cai W, Andres DA. Rit subfamily small GTPases: regulators in neuronal differentiation and survival. Cellular Signalling. 25: 2060-8. PMID 23770287 DOI: 10.1016/J.Cellsig.2013.06.002 |
0.626 |
|
| 2012 |
Cai W, Rudolph JL, Sengoku T, Andres DA. Rit GTPase regulates a p38 MAPK-dependent neuronal survival pathway. Neuroscience Letters. 531: 125-30. PMID 23123784 DOI: 10.1016/J.Neulet.2012.10.036 |
0.646 |
|
| 2012 |
Shi GX, Cai W, Andres DA. Rit-mediated stress resistance involves a p38-mitogen- and stress-activated protein kinase 1 (MSK1)-dependent cAMP response element-binding protein (CREB) activation cascade. The Journal of Biological Chemistry. 287: 39859-68. PMID 23038261 DOI: 10.1074/Jbc.M112.384248 |
0.639 |
|
| 2012 |
Magyar J, Kiper CE, Sievert G, Cai W, Shi GX, Crump SM, Li L, Niederer S, Smith N, Andres DA, Satin J. Rem-GTPase regulates cardiac myocyte L-type calcium current. Channels (Austin, Tex.). 6: 166-73. PMID 22854599 DOI: 10.4161/Chan.20192 |
0.564 |
|
| 2012 |
Cai W, Carlson SW, Brelsfoard JM, Mannon CE, Moncman CL, Saatman KE, Andres DA. Rit GTPase signaling promotes immature hippocampal neuronal survival. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 9887-97. PMID 22815504 DOI: 10.1523/Jneurosci.0375-12.2012 |
0.6 |
|
| 2012 |
Gunton JE, Sisavanh M, Stokes RA, Satin J, Satin LS, Zhang M, Liu SM, Cai W, Cheng K, Cooney GJ, Laybutt DR, So T, Molero JC, Grey ST, Andres DA, et al. Mice deficient in GEM GTPase show abnormal glucose homeostasis due to defects in beta-cell calcium handling. Plos One. 7: e39462. PMID 22761801 DOI: 10.1371/Journal.Pone.0039462 |
0.66 |
|
| 2011 |
Cai W, Rudolph JL, Harrison SM, Jin L, Frantz AL, Harrison DA, Andres DA. An evolutionarily conserved Rit GTPase-p38 MAPK signaling pathway mediates oxidative stress resistance. Molecular Biology of the Cell. 22: 3231-41. PMID 21737674 DOI: 10.1091/Mbc.E11-05-0400 |
0.648 |
|
| 2011 |
Shi GX, Andres DA, Cai W. Ras family small GTPase-mediated neuroprotective signaling in stroke. Central Nervous System Agents in Medicinal Chemistry. 11: 114-37. PMID 21521171 DOI: 10.2174/187152411796011349 |
0.613 |
|
| 2007 |
Cai W, Shi G, Rudolph JL, Andres DA. TrkA‐mediated Activation of the Rit GTPase The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A617-A |
0.544 |
|
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