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Edward A. Motea, Ph.D. - Publications

Affiliations: 
2012 Chemistry Case Western Reserve University, Cleveland Heights, OH, United States 
Area:
Biochemistry
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20 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Wettasinghe AP, Singh N, Starcher CL, DiTusa CC, Ishak-Boushaki Z, Kahanda D, McMullen R, Motea EA, Slinker JD. Detecting Attomolar DNA-Damaging Anticancer Drug Activity in Cell Lysates with Electrochemical DNA Devices. Acs Sensors. PMID 34156840 DOI: 10.1021/acssensors.1c00365  0.412
2020 Starcher CL, Pay SL, Singh N, Yeh IJ, Bhandare SB, Su X, Huang X, Bey EA, Motea EA, Boothman DA. Targeting Base Excision Repair in Cancer: NQO1-Bioactivatable Drugs Improve Tumor Selectivity and Reduce Treatment Toxicity Through Radiosensitization of Human Cancer. Frontiers in Oncology. 10: 1575. PMID 32974194 DOI: 10.3389/Fonc.2020.01575  0.418
2020 Patidar PL, Viera T, Morales JC, Singh N, Motea EA, Khandelwal M, Fattah FJ. XRN2 interactome reveals its synthetic lethal relationship with PARP1 inhibition. Scientific Reports. 10: 14253. PMID 32859985 DOI: 10.1038/S41598-020-71203-7  0.525
2020 Singh N, Pay SL, Bhandare SB, Arimpur U, Motea EA. Therapeutic Strategies and Biomarkers to Modulate PARP Activity for Targeted Cancer Therapy. Cancers. 12. PMID 32295316 DOI: 10.3390/Cancers12040972  0.4
2019 Motea EA, Huang X, Singh N, Kilgore JA, Williams NS, Xie XJ, Gerber DE, Beg M, Bey EA, Boothman DA. NQO1-dependent, tumor-selective radiosensitization of non-small cell lung cancers. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30617135 DOI: 10.1158/1078-0432.Ccr-18-2560  0.319
2018 Motea EA, Fattah FJ, Xiao L, Girard L, Rommel A, Morales JC, Patidar P, Zhou Y, Porter A, Xie Y, Minna JD, Boothman DA. Kub5-Hera RPRD1B deficiency promotes "BRCAness" and vulnerability to PARP inhibition in BRCA-proficient Breast Cancers. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30108102 DOI: 10.1158/1078-0432.Ccr-17-1118  0.319
2017 Choi JS, Kim S, Motea E, Berdis A. Inhibiting translesion DNA synthesis as an approach to combat drug resistance to DNA damaging agents. Oncotarget. PMID 28489578 DOI: 10.18632/Oncotarget.17254  0.55
2016 Huang X, Motea EA, Moore ZR, Yao J, Dong Y, Chakrabarti G, Kilgore JA, Silvers MA, Patidar PL, Cholka A, Fattah F, Cha Y, Anderson GG, Kusko R, Peyton M, et al. Leveraging an NQO1 Bioactivatable Drug for Tumor-Selective Use of Poly(ADP-ribose) Polymerase Inhibitors. Cancer Cell. 30: 940-952. PMID 27960087 DOI: 10.1016/J.Ccell.2016.11.006  0.428
2016 Morales JC, Richard P, Patidar PL, Motea EA, Dang TT, Manley JL, Boothman DA. XRN2 Links Transcription Termination to DNA Damage and Replication Stress. Plos Genetics. 12: e1006107. PMID 27437695 DOI: 10.1371/Journal.Pgen.1006107  0.422
2016 Patidar PL, Motea EA, Fattah FJ, Zhou Y, Morales JC, Xie Y, Garner HR, Boothman DA. The Kub5-Hera/RPRD1B interactome: a novel role in preserving genetic stability by regulating DNA mismatch repair. Nucleic Acids Research. PMID 26819409 DOI: 10.1093/Nar/Gkv1492  0.447
2014 Morales JC, Richard P, Rommel A, Fattah FJ, Motea EA, Patidar PL, Xiao L, Leskov K, Wu SY, Hittelman WN, Chiang CM, Manley JL, Boothman DA. Kub5-Hera, the human Rtt103 homolog, plays dual functional roles in transcription termination and DNA repair. Nucleic Acids Research. 42: 4996-5006. PMID 24589584 DOI: 10.1093/Nar/Gku160  0.404
2013 Golden J, Motea E, Zhang X, Choi JS, Feng Y, Xu Y, Lee I, Berdis AJ. Development and characterization of a non-natural nucleoside that displays anticancer activity against solid tumors. Acs Chemical Biology. 8: 2452-65. PMID 23992753 DOI: 10.1021/Cb400350H  0.623
2013 Motea EA, Lee I, Berdis AJ. Insights into the roles of desolvation and π-electron interactions during DNA polymerization. Chembiochem : a European Journal of Chemical Biology. 14: 489-98. PMID 23404822 DOI: 10.1002/Cbic.201200649  0.65
2012 Ahmad MF, Wan Q, Jha S, Motea E, Berdis A, Dealwis C. Evaluating the therapeutic potential of a non-natural nucleotide that inhibits human ribonucleotide reductase. Molecular Cancer Therapeutics. 11: 2077-86. PMID 22933704 DOI: 10.1158/1535-7163.Mct-12-0199  0.358
2012 Motea EA, Lee I, Berdis AJ. A non-natural nucleoside with combined therapeutic and diagnostic activities against leukemia. Acs Chemical Biology. 7: 988-98. PMID 22390204 DOI: 10.1021/Cb300038F  0.617
2012 Motea EA, Lee I, Berdis AJ. Development of a 'clickable' non-natural nucleotide to visualize the replication of non-instructional DNA lesions. Nucleic Acids Research. 40: 2357-67. PMID 22086959 DOI: 10.1093/Nar/Gkr980  0.644
2011 Motea EA, Lee I, Berdis AJ. Quantifying the energetic contributions of desolvation and π-electron density during translesion DNA synthesis. Nucleic Acids Research. 39: 1623-37. PMID 20952399 DOI: 10.1093/Nar/Gkq925  0.626
2010 Zhang X, Motea E, Lee I, Berdis AJ. Replication of a universal nucleobase provides unique insight into the role of entropy during DNA polymerization and pyrophosphorolysis. Biochemistry. 49: 3009-23. PMID 20187654 DOI: 10.1021/Bi901523Y  0.645
2010 Motea EA, Berdis AJ. Terminal deoxynucleotidyl transferase: the story of a misguided DNA polymerase. Biochimica Et Biophysica Acta. 1804: 1151-66. PMID 19596089 DOI: 10.1016/J.Bbapap.2009.06.030  0.553
2008 Sheriff A, Motea E, Lee I, Berdis AJ. Mechanism and dynamics of translesion DNA synthesis catalyzed by the Escherichia coli Klenow fragment. Biochemistry. 47: 8527-37. PMID 18652487 DOI: 10.1021/Bi800324R  0.657
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