Mark Swingle, Ph.D. - Publications

Affiliations: 
2006 University of South Alabama, Mobile, AL, United States 
Area:
Biochemistry

19 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Papke CM, Smolen KA, Swingle MR, Cressey L, Heng RA, Toporsian M, Deng L, Hagen J, Shen Y, Chung WK, Kettenbach AN, Honkanen RE. A disorder-related variant (E420K) of a PP2A-regulatory subunit (PPP2R5D) causes constitutively active AKT-mTOR signaling and uncoordinated cell growth. The Journal of Biological Chemistry. 100313. PMID 33482199 DOI: 10.1016/j.jbc.2021.100313  0.92
2019 D'Arcy BM, Swingle MR, Schambeau L, Pannell L, Prakash A, Honkanen RE. Development of a Synthetic 3-ketosteroid Δ-dehydrogenase for the Generation of a Novel Catabolic Pathway Enabling Cholesterol Degradation in Human Cells. Scientific Reports. 9: 5969. PMID 30979909 DOI: 10.1038/s41598-019-42046-8  0.92
2019 D'Arcy BM, Swingle MR, Papke CM, Abney KA, Bouska ES, Prakash A, Honkanen RE. The Antitumor Drug LB-100 is a Catalytic Inhibitor of Protein Phosphatase 2A (PPP2CA) and 5 (PPP5C) Coordinating with the Catalytic Metals in the Active Site of PP5C. Molecular Cancer Therapeutics. PMID 30679389 DOI: 10.1158/1535-7163.MCT-17-1143  0.92
2018 Swingle MR, Honkanen RE. Inhibitors of Serine/Threonine Protein Phosphatases: Biochemical and Structural Studies Provide Insight for Further Development. Current Medicinal Chemistry. PMID 29737249 DOI: 10.2174/0929867325666180508095242  0.92
2017 Choy MS, Swingle M, D'Arcy B, Abney K, Rusin SF, Kettenbach AN, Page R, Honkanen RE, Peti W. The PP1:tautomycetin complex reveals a path towards the development of PP1-specific inhibitors. Journal of the American Chemical Society. PMID 29156132 DOI: 10.1021/jacs.7b09368  0.92
2016 Swingle M, Volmar CH, Saldanha SA, Chase P, Eberhart C, Salter EA, D'Arcy B, Schroeder CE, Golden JE, Wierzbicki A, Hodder P, Honkanen RE. An Ultra-High-Throughput Screen for Catalytic Inhibitors of Serine/Threonine Protein Phosphatases Types 1 and 5 (PP1C and PP5C). Journal of Biomolecular Screening. PMID 27628691 DOI: 10.1177/1087057116668852  0.92
2016 Chattopadhyay D, Swingle MR, Salter EA, Wood E, D'Arcy B, Zivanov C, Abney K, Musiyenko A, Rusin SF, Kettenbach A, Yet L, Schroeder CE, Golden JE, Dunham WH, Gingras AC, et al. Crystal Structures and Mutagenesis of PPP-family ser/thr Protein Phosphatases Elucidate the Selectivity of Cantharidin and Novel Norcantharidin-based Inhibitors of PP5C. Biochemical Pharmacology. PMID 27002182 DOI: 10.1016/j.bcp.2016.03.011  0.92
2014 Swingle MR, Honkanen RE. Development and validation of a robust and sensitive assay for the discovery of selective inhibitors for serine/threonine protein phosphatases PP1α (PPP1C) and PP5 (PPP5C). Assay and Drug Development Technologies. 12: 481-96. PMID 25383722 DOI: 10.1089/adt.2014.603  0.92
2011 Yang X, Liu Y, Yang XM, Hu F, Cui L, Swingle MR, Honkanen RE, Soltani P, Tissier R, Cohen MV, Downey JM. Cardioprotection by mild hypothermia during ischemia involves preservation of ERK activity. Basic Research in Cardiology. 106: 421-30. PMID 21399968 DOI: 10.1007/s00395-011-0165-0  0.92
2010 Burke CP, Swingle MR, Honkanen RE, Boger DL. Total synthesis and evaluation of phostriecin and key structural analogues. The Journal of Organic Chemistry. 75: 7505-13. PMID 20669916 DOI: 10.1021/jo1010203  0.92
2009 Swingle MR, Amable L, Lawhorn BG, Buck SB, Burke CP, Ratti P, Fischer KL, Boger DL, Honkanen RE. Structure-activity relationship studies of fostriecin, cytostatin, and key analogs, with PP1, PP2A, PP5, and( beta12-beta13)-chimeras (PP1/PP2A and PP5/PP2A), provide further insight into the inhibitory actions of fostriecin family inhibitors. The Journal of Pharmacology and Experimental Therapeutics. 331: 45-53. PMID 19592665 DOI: 10.1124/jpet.109.155630  0.92
2008 Golden T, Swingle M, Honkanen RE. The role of serine/threonine protein phosphatase type 5 (PP5) in the regulation of stress-induced signaling networks and cancer. Cancer Metastasis Reviews. 27: 169-78. PMID 18253812 DOI: 10.1007/s10555-008-9125-z  0.92
2007 Ni L, Swingle MS, Bourgeois AC, Honkanen RE. High yield expression of serine/threonine protein phosphatase type 5, and a fluorescent assay suitable for use in the detection of catalytic inhibitors. Assay and Drug Development Technologies. 5: 645-53. PMID 17939754 DOI: 10.1089/adt.2007.079  0.64
2007 Swingle M, Ni L, Honkanen RE. Small-molecule inhibitors of ser/thr protein phosphatases: specificity, use and common forms of abuse. Methods in Molecular Biology (Clifton, N.J.). 365: 23-38. PMID 17200551 DOI: 10.1385/1-59745-267-X:23  0.92
2006 Lawhorn BG, Boga SB, Wolkenberg SE, Colby DA, Gauss CM, Swingle MR, Amable L, Honkanen RE, Boger DL. Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: impact on PP2A inhibition. Journal of the American Chemical Society. 128: 16720-32. PMID 17177422 DOI: 10.1021/ja066477d  0.92
2004 Swingle MR, Honkanen RE, Ciszak EM. Structural basis for the catalytic activity of human serine/threonine protein phosphatase-5. The Journal of Biological Chemistry. 279: 33992-9. PMID 15155720 DOI: 10.1074/jbc.M402855200  0.92
2003 Buck SB, Hardouin C, Ichikawa S, Soenen DR, Gauss CM, Hwang I, Swingle MR, Bonness KM, Honkanen RE, Boger DL. Fundamental role of the fostriecin unsaturated lactone and implications for selective protein phosphatase inhibition. Journal of the American Chemical Society. 125: 15694-5. PMID 14677930 DOI: 10.1021/ja038672n  0.92
2001 Dean DA, Urban G, Aragon IV, Swingle M, Miller B, Rusconi S, Bueno M, Dean NM, Honkanen RE. Serine/threonine protein phosphatase 5 (PP5) participates in the regulation of glucocorticoid receptor nucleocytoplasmic shuttling. Bmc Cell Biology. 2: 6. PMID 11389770 DOI: 10.1186/1471-2121-2-6  0.92
2000 Huang X, Swingle MR, Honkanen RE. Photoreceptor serine/threonine protein phosphatase type 7: cloning, expression, and functional analysis. Methods in Enzymology. 315: 579-93. PMID 10736728  0.92
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