Angelo Aguilar, Ph.D. - Publications

Affiliations: 
2008 Department of Chemistry Kansas State University, Manhattan, KS, United States 
Area:
Organic Chemistry

4 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Aguilar A, Lu J, Liu L, Du D, Bernard D, McEachern D, Przybranowski S, Li X, Luo R, Wen B, Sun D, Wang H, Wen J, Wang G, Zhai Y, et al. Discovery of 4-((3'R,4'S,5'R)-6″-Chloro-4'-(3-chloro-2-fluorophenyl)-1'-ethyl-2″-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3″-indoline]-5'-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine Double Minute 2 (MDM2) Inhibitor in Clinical Development. Journal of Medicinal Chemistry. PMID 28339198 DOI: 10.1021/acs.jmedchem.6b01665  0.36
2015 Lu J, Aguilar A, Zou B, Bao W, Koldas S, Shi A, Desper J, Wangemann P, Xie XS, Hua DH. Chemical synthesis of tetracyclic terpenes and evaluation of antagonistic activity on endothelin-A receptors and voltage-gated calcium channels. Bioorganic & Medicinal Chemistry. 23: 5985-98. PMID 26190460 DOI: 10.1016/j.bmc.2015.06.055  0.36
2014 Aguilar A, Sun W, Liu L, Lu J, McEachern D, Bernard D, Deschamps JR, Wang S. Design of chemically stable, potent, and efficacious MDM2 inhibitors that exploit the retro-mannich ring-opening-cyclization reaction mechanism in spiro-oxindoles. Journal of Medicinal Chemistry. 57: 10486-98. PMID 25496041 DOI: 10.1021/jm501541j  0.36
2014 Wang S, Sun W, Zhao Y, McEachern D, Meaux I, Barrière C, Stuckey JA, Meagher JL, Bai L, Liu L, Hoffman-Luca CG, Lu J, Shangary S, Yu S, Bernard D, ... Aguilar A, et al. SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression. Cancer Research. 74: 5855-65. PMID 25145672 DOI: 10.1158/0008-5472.CAN-14-0799  0.36
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