Juan Zhen, Ph.D. - Publications

2005 Illinois State University, Normal, IL, United States 
Neuroscience Biology, Biochemistry

42 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Reid KM, Spaull R, Salian S, Barwick K, Meyer E, Zhen J, Hirata H, Sheipouri D, Benkerroum H, Gorman KM, Papandreou A, Simpson MA, Hirano Y, Farabella I, Topf M, et al. MED27, SLC6A7, and MPPE1 Variants in a Complex Neurodevelopmental Disorder with Severe Dystonia. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 35876425 DOI: 10.1002/mds.29147  0.46
2018 Mikelman SR, Guptaroy B, Schmitt KC, Jones KT, Zhen J, Reith MEA, Gnegy ME. Tamoxifen Directly Interacts with the Dopamine Transporter. The Journal of Pharmacology and Experimental Therapeutics. PMID 30108161 DOI: 10.1124/Jpet.118.248179  0.558
2017 Reith MEA, Jones KT, Zhen J, Topiol S. Latch and trigger role for R445 in DAT transport explains molecular basis of DTDS. Bioorganic & Medicinal Chemistry Letters. PMID 29258773 DOI: 10.1016/J.Bmcl.2017.12.016  0.491
2017 Zhen J, Reith MEA. Functional properties of dopamine transporter oligomers after copper linking. Journal of Neurochemistry. PMID 29168892 DOI: 10.1111/Jnc.14259  0.49
2017 Challasivakanaka S, Zhen J, Smith ME, Reith MEA, Foster JD, Vaughan RA. Dopamine Transporter Phosphorylation Site Threonine 53 is Stimulated by Amphetamines and Regulates Dopamine Transport, Efflux, and Cocaine Analog Binding. The Journal of Biological Chemistry. PMID 28939767 DOI: 10.1074/Jbc.M117.787002  0.512
2017 Jones KT, Woods C, Zhen J, Antonio T, Carr KD, Reith ME. Effects of diet and insulin on dopamine transporter activity and expression in rat caudate-putamen, nucleus accumbens, and midbrain. Journal of Neurochemistry. 140: 728-740. PMID 27973691 DOI: 10.1111/Jnc.13930  0.636
2016 Zhen J, Reith ME. Impact of disruption of secondary binding site S2 on dopamine transporter function. Journal of Neurochemistry. 138: 694-9. PMID 27315582 DOI: 10.1111/Jnc.13704  0.697
2016 Zhen J, Antonio T, Jacob JC, Grandy DK, Reith MEA, Dutta AK, Selley DE. Efficacy of Hybrid Tetrahydrobenzo[d]thiazole Based Aryl Piperazines D-264 and D-301 at D₂ and D₃ Receptors. Neurochemical Research. 41: 328-339. PMID 26718829 DOI: 10.1007/S11064-015-1808-6  0.367
2016 Ng J, Zhen J, Meyer E, Erreger K, Pope S, Borck G, Heales SJHR, Reith MEA, Rahim AA, Waddington SN, Kurian MA. Novel therapeutic approaches for childhood parkinsonism The Lancet. 387: S77. DOI: 10.1016/S0140-6736(16)00464-5  0.361
2015 Stödberg T, McTague A, Ruiz AJ, Hirata H, Zhen J, Long P, Farabella I, Meyer E, Kawahara A, Vassallo G, Stivaros SM, Bjursell MK, Stranneheim H, Tigerschiöld S, Persson B, et al. Mutations in SLC12A5 in epilepsy of infancy with migrating focal seizures. Nature Communications. 6: 8038. PMID 26333769 DOI: 10.1038/Ncomms9038  0.536
2015 Zhen J, Antonio T, Ali S, Neve KA, Dutta AK, Reith ME. Use of radiolabeled antagonist assays for assessing agonism at D2 and D3 dopamine receptors: comparison with functional GTPγS assays. Journal of Neuroscience Methods. 248: 7-15. PMID 25840364 DOI: 10.1016/J.Jneumeth.2015.03.028  0.608
2015 Zhen J, Antonio T, Cheng SY, Ali S, Jones KT, Reith ME. Dopamine transporter oligomerization: impact of combining protomers with differential cocaine analog binding affinities. Journal of Neurochemistry. 133: 167-73. PMID 25580950 DOI: 10.1111/Jnc.13025  0.694
2014 Ng J, Zhen J, Meyer E, Erreger K, Li Y, Kakar N, Ahmad J, Thiele H, Kubisch C, Rider NL, Morton DH, Strauss KA, Puffenberger EG, D'Agnano D, Anikster Y, et al. Dopamine transporter deficiency syndrome: phenotypic spectrum from infancy to adulthood. Brain : a Journal of Neurology. 137: 1107-19. PMID 24613933 DOI: 10.1093/Brain/Awu022  0.68
2013 Ng J, Li Y, Zhen J, Kakar N, Ahmad J, Thiele H, Kubisch C, Rider N, Strauss K, Holmes-Morton D, D'Agnano D, Anikster Y, Carducci C, Hyland K, Rostein M, et al. O1 – 1990 Clinical spectrum of dopamine transporter deficiency syndrome: from infantile parkinsonism-dystonia to juvenile parkinsonism European Journal of Paediatric Neurology. 17: S1. DOI: 10.1016/S1090-3798(13)00130-X  0.404
2012 Santra S, Gogoi S, Gopishetty B, Antonio T, Zhen J, Reith ME, Dutta AK. Structural exploration of (3S,6S)-6-benzhydryl-N-benzyltetrahydro-2H-pyran-3-amine analogues: identification of potent triple monoamine reuptake inhibitors as potential antidepressants. Chemmedchem. 7: 2093-100. PMID 23060293 DOI: 10.1002/Cmdc.201200352  0.685
2012 Jones KT, Zhen J, Reith ME. Importance of cholesterol in dopamine transporter function. Journal of Neurochemistry. 123: 700-15. PMID 22957537 DOI: 10.1111/Jnc.12007  0.618
2012 Zhen J, Ali S, Dutta AK, Reith ME. Characterization of [³H]CFT binding to the norepinephrine transporter suggests that binding of CFT and nisoxetine is not mutually exclusive. Journal of Neuroscience Methods. 203: 19-27. PMID 21933682 DOI: 10.1016/J.Jneumeth.2011.08.044  0.678
2011 Dutta AK, Gopishetty B, Gogoi S, Ali S, Zhen J, Reith M. The novel trisubstituted pyran derivative D-142 has triple monoamine reuptake inhibitory activity and exerts potent antidepressant-like activity in rodents. European Journal of Pharmacology. 671: 39-44. PMID 21963455 DOI: 10.1016/J.Ejphar.2011.09.162  0.645
2011 Gopishetty B, Hazeldine S, Santra S, Johnson M, Modi G, Ali S, Zhen J, Reith M, Dutta A. Further structure-activity relationship studies on 4-((((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenol: identification of compounds with triple uptake inhibitory activity as potential antidepressant agents. Journal of Medicinal Chemistry. 54: 2924-32. PMID 21446715 DOI: 10.1021/Jm200020A  0.679
2011 Kurian MA, Li Y, Zhen J, Meyer E, Hai N, Christen HJ, Hoffmann GF, Jardine P, von Moers A, Mordekar SR, O'Callaghan F, Wassmer E, Wraige E, Dietrich C, Lewis T, et al. Clinical and molecular characterisation of hereditary dopamine transporter deficiency syndrome: an observational cohort and experimental study. The Lancet. Neurology. 10: 54-62. PMID 21112253 DOI: 10.1016/S1474-4422(10)70269-6  0.662
2011 Kortagere S, Cheng SY, Antonio T, Zhen J, Reith ME, Dutta AK. Interaction of novel hybrid compounds with the D3 dopamine receptor: Site-directed mutagenesis and homology modeling studies. Biochemical Pharmacology. 81: 157-63. PMID 20833147 DOI: 10.1016/J.Bcp.2010.08.026  0.673
2010 Nyola A, Karpowich NK, Zhen J, Marden J, Reith ME, Wang DN. Substrate and drug binding sites in LeuT. Current Opinion in Structural Biology. 20: 415-22. PMID 20739005 DOI: 10.1016/J.Sbi.2010.05.007  0.652
2010 Zhen J, Antonio T, Dutta AK, Reith ME. Concentration of receptor and ligand revisited in a modified receptor binding protocol for high-affinity radioligands: [3H]Spiperone binding to D2 and D3 dopamine receptors. Journal of Neuroscience Methods. 188: 32-8. PMID 20122961 DOI: 10.1016/J.Jneumeth.2010.01.031  0.616
2010 Ghosh B, Antonio T, Zhen J, Kharkar P, Reith ME, Dutta AK. Development of (S)-N6-(2-(4-(isoquinolin-1-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]-thiazole-2,6-diamine and its analogue as a D3 receptor preferring agonist: potent in vivo activity in Parkinson's disease animal models. Journal of Medicinal Chemistry. 53: 1023-37. PMID 20038106 DOI: 10.1021/Jm901184N  0.616
2010 Schmitt KC, Zhen J, Kharkar P, Mishra M, Chen N, Dutta AK, Reith MEA. Erratum: Interaction of cocaine-, benztropine-, and GBR12909-like compounds with wildtype and mutant human dopamine transporters: Molecular features that differentially determine antagonist binding properties (Journal of Neurochemistry (2008) 107 (928-940)) Journal of Neurochemistry. 115. DOI: 10.1111/J.1471-4159.2010.06911.X  0.524
2009 Liang YJ, Zhen J, Chen N, Reith ME. Interaction of catechol and non-catechol substrates with externally or internally facing dopamine transporters. Journal of Neurochemistry. 109: 981-94. PMID 19519772 DOI: 10.1111/J.1471-4159.2009.06034.X  0.688
2009 Kurian MA, Zhen J, Cheng SY, Li Y, Mordekar SR, Jardine P, Morgan NV, Meyer E, Tee L, Pasha S, Wassmer E, Heales SJ, Gissen P, Reith ME, Maher ER. Homozygous loss-of-function mutations in the gene encoding the dopamine transporter are associated with infantile parkinsonism-dystonia. The Journal of Clinical Investigation. 119: 1595-603. PMID 19478460 DOI: 10.1172/Jci39060  0.631
2009 Kharkar PS, Batman AM, Zhen J, Beardsley PM, Reith ME, Dutta AK. Synthesis and biological characterization of (3R,4R)-4-(2-(benzhydryloxy)ethyl)-1-((R)-2-hydroxy-2-phenylethyl)-piperidin-3-ol and its stereoisomers for activity toward monoamine transporters. Chemmedchem. 4: 1075-85. PMID 19449323 DOI: 10.1002/Cmdc.200900085  0.704
2009 Zhou Z, Zhen J, Karpowich NK, Law CJ, Reith ME, Wang DN. Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures. Nature Structural & Molecular Biology. 16: 652-7. PMID 19430461 DOI: 10.1038/Nsmb.1602  0.683
2008 Schmitt KC, Zhen J, Kharkar P, Mishra M, Chen N, Dutta AK, Reith ME. Interaction of cocaine-, benztropine-, and GBR12909-like compounds with wild-type and mutant human dopamine transporters: molecular features that differentially determine antagonist-binding properties. Journal of Neurochemistry. 107: 928-40. PMID 18786172 DOI: 10.1111/J.1471-4159.2008.05667.X  0.673
2008 Mishra M, Kolhatkar R, Zhen J, Parrington I, Reith ME, Dutta AK. Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an exocyclic hydroxyl group: interaction with dopamine, serotonin, and norepinephrine transporters. Bioorganic & Medicinal Chemistry. 16: 2769-78. PMID 18249549 DOI: 10.1016/J.Bmc.2008.01.009  0.698
2008 Biswas S, Zhang S, Fernandez F, Ghosh B, Zhen J, Kuzhikandathil E, Reith ME, Dutta AK. Further structure-activity relationships study of hybrid 7-{[2-(4-phenylpiperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol analogues: identification of a high-affinity D3-preferring agonist with potent in vivo activity with long duration of action. Journal of Medicinal Chemistry. 51: 101-17. PMID 18072730 DOI: 10.1021/Jm070860R  0.631
2007 Zhou Z, Zhen J, Karpowich NK, Goetz RM, Law CJ, Reith ME, Wang DN. LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake. Science (New York, N.Y.). 317: 1390-3. PMID 17690258 DOI: 10.1126/Science.1147614  0.688
2006 Zhang S, Fernandez F, Hazeldine S, Deschamps J, Zhen J, Reith ME, Dutta AK. Further structural exploration of trisubstituted asymmetric pyran derivatives (2S,4R,5R)-2-benzhydryl-5-benzylamino-tetrahydropyran-4-ol and their corresponding disubstituted (3S,6S) pyran derivatives: a proposed pharmacophore model for high-affinity interaction with the dopamine, serotonin, and norepinephrine transporters. Journal of Medicinal Chemistry. 49: 4239-47. PMID 16821783 DOI: 10.1021/Jm0601699  0.708
2006 Reith ME, Zhen J, Chen N. The importance of company: Na+ and Cl- influence substrate interaction with SLC6 transporters and other proteins. Handbook of Experimental Pharmacology. 75-93. PMID 16722231 DOI: 10.1007/3-540-29784-7_4  0.607
2006 Zhen J, Reith ME, Carr KD. Chronic food restriction and dopamine transporter function in rat striatum. Brain Research. 1082: 98-101. PMID 16516172 DOI: 10.1016/J.Brainres.2006.01.094  0.624
2006 Zhang S, Zhen J, Reith ME, Dutta AK. Design, synthesis, and preliminary SAR study of 3- and 6-side-chain-extended tetrahydro-pyran analogues of cis- and trans-(6-benzhydryl-tetrahydropyran-3-yl)-benzylamine. Bioorganic & Medicinal Chemistry. 14: 3953-66. PMID 16481172 DOI: 10.1016/J.Bmc.2006.01.051  0.682
2005 Zhen J, Chen N, Reith ME. Differences in interactions with the dopamine transporter as revealed by diminishment of Na(+) gradient and membrane potential: dopamine versus other substrates. Neuropharmacology. 49: 769-79. PMID 16122767 DOI: 10.1016/J.Neuropharm.2005.07.002  0.646
2005 Zhang S, Zhen J, Reith ME, Dutta AK. Discovery of novel trisubstituted asymmetric derivatives of (2S,4R,5R)-2-benzhydryl-5-benzylaminotetrahydropyran-4-ol, exhibiting high affinity for serotonin and norepinephrine transporters in a stereospecific manner. Journal of Medicinal Chemistry. 48: 4962-71. PMID 16033275 DOI: 10.1021/Jm049021K  0.698
2004 Zhen J, Maiti S, Chen N, Dutta AK, Reith ME. Interaction between a hydroxypiperidine analogue of 4-(2-benzhydryloxy-ethyl)-1-(4-fluorobenzyl)piperidine and Aspartate 68 in the human dopamine transporter. European Journal of Pharmacology. 506: 17-26. PMID 15588620 DOI: 10.1016/J.Ejphar.2004.10.028  0.611
2004 Zhang S, Zhen J, Reith ME, Dutta AK. Structural requirements for 2,4- and 3,6-disubstituted pyran biomimetics of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine compounds to interact with monoamine transporters. Bioorganic & Medicinal Chemistry. 12: 6301-15. PMID 15519172 DOI: 10.1016/J.Bmc.2004.07.069  0.692
2004 Chen N, Zhen J, Reith ME. Mutation of Trp84 and Asp313 of the dopamine transporter reveals similar mode of binding interaction for GBR12909 and benztropine as opposed to cocaine. Journal of Neurochemistry. 89: 853-64. PMID 15140185 DOI: 10.1111/J.1471-4159.2004.02386.X  0.642
Show low-probability matches.