| Year |
Citation |
Score |
| 2022 |
Reid KM, Spaull R, Salian S, Barwick K, Meyer E, Zhen J, Hirata H, Sheipouri D, Benkerroum H, Gorman KM, Papandreou A, Simpson MA, Hirano Y, Farabella I, Topf M, et al. MED27, SLC6A7, and MPPE1 Variants in a Complex Neurodevelopmental Disorder with Severe Dystonia. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 35876425 DOI: 10.1002/mds.29147 |
0.46 |
|
| 2018 |
Mikelman SR, Guptaroy B, Schmitt KC, Jones KT, Zhen J, Reith MEA, Gnegy ME. Tamoxifen Directly Interacts with the Dopamine Transporter. The Journal of Pharmacology and Experimental Therapeutics. PMID 30108161 DOI: 10.1124/Jpet.118.248179 |
0.558 |
|
| 2017 |
Reith MEA, Jones KT, Zhen J, Topiol S. Latch and trigger role for R445 in DAT transport explains molecular basis of DTDS. Bioorganic & Medicinal Chemistry Letters. PMID 29258773 DOI: 10.1016/J.Bmcl.2017.12.016 |
0.491 |
|
| 2017 |
Zhen J, Reith MEA. Functional properties of dopamine transporter oligomers after copper linking. Journal of Neurochemistry. PMID 29168892 DOI: 10.1111/Jnc.14259 |
0.49 |
|
| 2017 |
Challasivakanaka S, Zhen J, Smith ME, Reith MEA, Foster JD, Vaughan RA. Dopamine Transporter Phosphorylation Site Threonine 53 is Stimulated by Amphetamines and Regulates Dopamine Transport, Efflux, and Cocaine Analog Binding. The Journal of Biological Chemistry. PMID 28939767 DOI: 10.1074/Jbc.M117.787002 |
0.512 |
|
| 2017 |
Jones KT, Woods C, Zhen J, Antonio T, Carr KD, Reith ME. Effects of diet and insulin on dopamine transporter activity and expression in rat caudate-putamen, nucleus accumbens, and midbrain. Journal of Neurochemistry. 140: 728-740. PMID 27973691 DOI: 10.1111/Jnc.13930 |
0.636 |
|
| 2016 |
Zhen J, Reith ME. Impact of disruption of secondary binding site S2 on dopamine transporter function. Journal of Neurochemistry. 138: 694-9. PMID 27315582 DOI: 10.1111/Jnc.13704 |
0.697 |
|
| 2016 |
Zhen J, Antonio T, Jacob JC, Grandy DK, Reith MEA, Dutta AK, Selley DE. Efficacy of Hybrid Tetrahydrobenzo[d]thiazole Based Aryl Piperazines D-264 and D-301 at D₂ and D₃ Receptors. Neurochemical Research. 41: 328-339. PMID 26718829 DOI: 10.1007/S11064-015-1808-6 |
0.367 |
|
| 2016 |
Ng J, Zhen J, Meyer E, Erreger K, Pope S, Borck G, Heales SJHR, Reith MEA, Rahim AA, Waddington SN, Kurian MA. Novel therapeutic approaches for childhood parkinsonism The Lancet. 387: S77. DOI: 10.1016/S0140-6736(16)00464-5 |
0.361 |
|
| 2015 |
Stödberg T, McTague A, Ruiz AJ, Hirata H, Zhen J, Long P, Farabella I, Meyer E, Kawahara A, Vassallo G, Stivaros SM, Bjursell MK, Stranneheim H, Tigerschiöld S, Persson B, et al. Mutations in SLC12A5 in epilepsy of infancy with migrating focal seizures. Nature Communications. 6: 8038. PMID 26333769 DOI: 10.1038/Ncomms9038 |
0.536 |
|
| 2015 |
Zhen J, Antonio T, Ali S, Neve KA, Dutta AK, Reith ME. Use of radiolabeled antagonist assays for assessing agonism at D2 and D3 dopamine receptors: comparison with functional GTPγS assays. Journal of Neuroscience Methods. 248: 7-15. PMID 25840364 DOI: 10.1016/J.Jneumeth.2015.03.028 |
0.608 |
|
| 2015 |
Zhen J, Antonio T, Cheng SY, Ali S, Jones KT, Reith ME. Dopamine transporter oligomerization: impact of combining protomers with differential cocaine analog binding affinities. Journal of Neurochemistry. 133: 167-73. PMID 25580950 DOI: 10.1111/Jnc.13025 |
0.694 |
|
| 2014 |
Ng J, Zhen J, Meyer E, Erreger K, Li Y, Kakar N, Ahmad J, Thiele H, Kubisch C, Rider NL, Morton DH, Strauss KA, Puffenberger EG, D'Agnano D, Anikster Y, et al. Dopamine transporter deficiency syndrome: phenotypic spectrum from infancy to adulthood. Brain : a Journal of Neurology. 137: 1107-19. PMID 24613933 DOI: 10.1093/Brain/Awu022 |
0.68 |
|
| 2013 |
Ng J, Li Y, Zhen J, Kakar N, Ahmad J, Thiele H, Kubisch C, Rider N, Strauss K, Holmes-Morton D, D'Agnano D, Anikster Y, Carducci C, Hyland K, Rostein M, et al. O1 – 1990 Clinical spectrum of dopamine transporter deficiency syndrome: from infantile parkinsonism-dystonia to juvenile parkinsonism European Journal of Paediatric Neurology. 17: S1. DOI: 10.1016/S1090-3798(13)00130-X |
0.404 |
|
| 2012 |
Santra S, Gogoi S, Gopishetty B, Antonio T, Zhen J, Reith ME, Dutta AK. Structural exploration of (3S,6S)-6-benzhydryl-N-benzyltetrahydro-2H-pyran-3-amine analogues: identification of potent triple monoamine reuptake inhibitors as potential antidepressants. Chemmedchem. 7: 2093-100. PMID 23060293 DOI: 10.1002/Cmdc.201200352 |
0.685 |
|
| 2012 |
Jones KT, Zhen J, Reith ME. Importance of cholesterol in dopamine transporter function. Journal of Neurochemistry. 123: 700-15. PMID 22957537 DOI: 10.1111/Jnc.12007 |
0.618 |
|
| 2012 |
Zhen J, Ali S, Dutta AK, Reith ME. Characterization of [³H]CFT binding to the norepinephrine transporter suggests that binding of CFT and nisoxetine is not mutually exclusive. Journal of Neuroscience Methods. 203: 19-27. PMID 21933682 DOI: 10.1016/J.Jneumeth.2011.08.044 |
0.678 |
|
| 2011 |
Dutta AK, Gopishetty B, Gogoi S, Ali S, Zhen J, Reith M. The novel trisubstituted pyran derivative D-142 has triple monoamine reuptake inhibitory activity and exerts potent antidepressant-like activity in rodents. European Journal of Pharmacology. 671: 39-44. PMID 21963455 DOI: 10.1016/J.Ejphar.2011.09.162 |
0.645 |
|
| 2011 |
Gopishetty B, Hazeldine S, Santra S, Johnson M, Modi G, Ali S, Zhen J, Reith M, Dutta A. Further structure-activity relationship studies on 4-((((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenol: identification of compounds with triple uptake inhibitory activity as potential antidepressant agents. Journal of Medicinal Chemistry. 54: 2924-32. PMID 21446715 DOI: 10.1021/Jm200020A |
0.679 |
|
| 2011 |
Kurian MA, Li Y, Zhen J, Meyer E, Hai N, Christen HJ, Hoffmann GF, Jardine P, von Moers A, Mordekar SR, O'Callaghan F, Wassmer E, Wraige E, Dietrich C, Lewis T, et al. Clinical and molecular characterisation of hereditary dopamine transporter deficiency syndrome: an observational cohort and experimental study. The Lancet. Neurology. 10: 54-62. PMID 21112253 DOI: 10.1016/S1474-4422(10)70269-6 |
0.662 |
|
| 2011 |
Kortagere S, Cheng SY, Antonio T, Zhen J, Reith ME, Dutta AK. Interaction of novel hybrid compounds with the D3 dopamine receptor: Site-directed mutagenesis and homology modeling studies. Biochemical Pharmacology. 81: 157-63. PMID 20833147 DOI: 10.1016/J.Bcp.2010.08.026 |
0.673 |
|
| 2010 |
Nyola A, Karpowich NK, Zhen J, Marden J, Reith ME, Wang DN. Substrate and drug binding sites in LeuT. Current Opinion in Structural Biology. 20: 415-22. PMID 20739005 DOI: 10.1016/J.Sbi.2010.05.007 |
0.652 |
|
| 2010 |
Zhen J, Antonio T, Dutta AK, Reith ME. Concentration of receptor and ligand revisited in a modified receptor binding protocol for high-affinity radioligands: [3H]Spiperone binding to D2 and D3 dopamine receptors. Journal of Neuroscience Methods. 188: 32-8. PMID 20122961 DOI: 10.1016/J.Jneumeth.2010.01.031 |
0.616 |
|
| 2010 |
Ghosh B, Antonio T, Zhen J, Kharkar P, Reith ME, Dutta AK. Development of (S)-N6-(2-(4-(isoquinolin-1-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]-thiazole-2,6-diamine and its analogue as a D3 receptor preferring agonist: potent in vivo activity in Parkinson's disease animal models. Journal of Medicinal Chemistry. 53: 1023-37. PMID 20038106 DOI: 10.1021/Jm901184N |
0.616 |
|
| 2010 |
Schmitt KC, Zhen J, Kharkar P, Mishra M, Chen N, Dutta AK, Reith MEA. Erratum: Interaction of cocaine-, benztropine-, and GBR12909-like compounds with wildtype and mutant human dopamine transporters: Molecular features that differentially determine antagonist binding properties (Journal of Neurochemistry (2008) 107 (928-940)) Journal of Neurochemistry. 115. DOI: 10.1111/J.1471-4159.2010.06911.X |
0.524 |
|
| 2009 |
Liang YJ, Zhen J, Chen N, Reith ME. Interaction of catechol and non-catechol substrates with externally or internally facing dopamine transporters. Journal of Neurochemistry. 109: 981-94. PMID 19519772 DOI: 10.1111/J.1471-4159.2009.06034.X |
0.688 |
|
| 2009 |
Kurian MA, Zhen J, Cheng SY, Li Y, Mordekar SR, Jardine P, Morgan NV, Meyer E, Tee L, Pasha S, Wassmer E, Heales SJ, Gissen P, Reith ME, Maher ER. Homozygous loss-of-function mutations in the gene encoding the dopamine transporter are associated with infantile parkinsonism-dystonia. The Journal of Clinical Investigation. 119: 1595-603. PMID 19478460 DOI: 10.1172/Jci39060 |
0.631 |
|
| 2009 |
Kharkar PS, Batman AM, Zhen J, Beardsley PM, Reith ME, Dutta AK. Synthesis and biological characterization of (3R,4R)-4-(2-(benzhydryloxy)ethyl)-1-((R)-2-hydroxy-2-phenylethyl)-piperidin-3-ol and its stereoisomers for activity toward monoamine transporters. Chemmedchem. 4: 1075-85. PMID 19449323 DOI: 10.1002/Cmdc.200900085 |
0.704 |
|
| 2009 |
Zhou Z, Zhen J, Karpowich NK, Law CJ, Reith ME, Wang DN. Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures. Nature Structural & Molecular Biology. 16: 652-7. PMID 19430461 DOI: 10.1038/Nsmb.1602 |
0.683 |
|
| 2008 |
Schmitt KC, Zhen J, Kharkar P, Mishra M, Chen N, Dutta AK, Reith ME. Interaction of cocaine-, benztropine-, and GBR12909-like compounds with wild-type and mutant human dopamine transporters: molecular features that differentially determine antagonist-binding properties. Journal of Neurochemistry. 107: 928-40. PMID 18786172 DOI: 10.1111/J.1471-4159.2008.05667.X |
0.673 |
|
| 2008 |
Mishra M, Kolhatkar R, Zhen J, Parrington I, Reith ME, Dutta AK. Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an exocyclic hydroxyl group: interaction with dopamine, serotonin, and norepinephrine transporters. Bioorganic & Medicinal Chemistry. 16: 2769-78. PMID 18249549 DOI: 10.1016/J.Bmc.2008.01.009 |
0.698 |
|
| 2008 |
Biswas S, Zhang S, Fernandez F, Ghosh B, Zhen J, Kuzhikandathil E, Reith ME, Dutta AK. Further structure-activity relationships study of hybrid 7-{[2-(4-phenylpiperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol analogues: identification of a high-affinity D3-preferring agonist with potent in vivo activity with long duration of action. Journal of Medicinal Chemistry. 51: 101-17. PMID 18072730 DOI: 10.1021/Jm070860R |
0.631 |
|
| 2007 |
Zhou Z, Zhen J, Karpowich NK, Goetz RM, Law CJ, Reith ME, Wang DN. LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake. Science (New York, N.Y.). 317: 1390-3. PMID 17690258 DOI: 10.1126/Science.1147614 |
0.688 |
|
| 2006 |
Zhang S, Fernandez F, Hazeldine S, Deschamps J, Zhen J, Reith ME, Dutta AK. Further structural exploration of trisubstituted asymmetric pyran derivatives (2S,4R,5R)-2-benzhydryl-5-benzylamino-tetrahydropyran-4-ol and their corresponding disubstituted (3S,6S) pyran derivatives: a proposed pharmacophore model for high-affinity interaction with the dopamine, serotonin, and norepinephrine transporters. Journal of Medicinal Chemistry. 49: 4239-47. PMID 16821783 DOI: 10.1021/Jm0601699 |
0.708 |
|
| 2006 |
Reith ME, Zhen J, Chen N. The importance of company: Na+ and Cl- influence substrate interaction with SLC6 transporters and other proteins. Handbook of Experimental Pharmacology. 75-93. PMID 16722231 DOI: 10.1007/3-540-29784-7_4 |
0.607 |
|
| 2006 |
Zhen J, Reith ME, Carr KD. Chronic food restriction and dopamine transporter function in rat striatum. Brain Research. 1082: 98-101. PMID 16516172 DOI: 10.1016/J.Brainres.2006.01.094 |
0.624 |
|
| 2006 |
Zhang S, Zhen J, Reith ME, Dutta AK. Design, synthesis, and preliminary SAR study of 3- and 6-side-chain-extended tetrahydro-pyran analogues of cis- and trans-(6-benzhydryl-tetrahydropyran-3-yl)-benzylamine. Bioorganic & Medicinal Chemistry. 14: 3953-66. PMID 16481172 DOI: 10.1016/J.Bmc.2006.01.051 |
0.682 |
|
| 2005 |
Zhen J, Chen N, Reith ME. Differences in interactions with the dopamine transporter as revealed by diminishment of Na(+) gradient and membrane potential: dopamine versus other substrates. Neuropharmacology. 49: 769-79. PMID 16122767 DOI: 10.1016/J.Neuropharm.2005.07.002 |
0.646 |
|
| 2005 |
Zhang S, Zhen J, Reith ME, Dutta AK. Discovery of novel trisubstituted asymmetric derivatives of (2S,4R,5R)-2-benzhydryl-5-benzylaminotetrahydropyran-4-ol, exhibiting high affinity for serotonin and norepinephrine transporters in a stereospecific manner. Journal of Medicinal Chemistry. 48: 4962-71. PMID 16033275 DOI: 10.1021/Jm049021K |
0.698 |
|
| 2004 |
Zhen J, Maiti S, Chen N, Dutta AK, Reith ME. Interaction between a hydroxypiperidine analogue of 4-(2-benzhydryloxy-ethyl)-1-(4-fluorobenzyl)piperidine and Aspartate 68 in the human dopamine transporter. European Journal of Pharmacology. 506: 17-26. PMID 15588620 DOI: 10.1016/J.Ejphar.2004.10.028 |
0.611 |
|
| 2004 |
Zhang S, Zhen J, Reith ME, Dutta AK. Structural requirements for 2,4- and 3,6-disubstituted pyran biomimetics of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine compounds to interact with monoamine transporters. Bioorganic & Medicinal Chemistry. 12: 6301-15. PMID 15519172 DOI: 10.1016/J.Bmc.2004.07.069 |
0.692 |
|
| 2004 |
Chen N, Zhen J, Reith ME. Mutation of Trp84 and Asp313 of the dopamine transporter reveals similar mode of binding interaction for GBR12909 and benztropine as opposed to cocaine. Journal of Neurochemistry. 89: 853-64. PMID 15140185 DOI: 10.1111/J.1471-4159.2004.02386.X |
0.642 |
|
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