Husam S. Younis, Ph.D. - Publications

2001 University of Arizona, Tucson, AZ 
Toxicology, Pharmacology

25 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Crooke ST, Baker BF, Kwoh J, Cheng W, Schulz D, Xia S, Salgado N, Bui HH, Hart CE, Burel S, Younis HS, Geary RS, Henry SP, Bhanot S. Integrated Safety Assessment of 2'-O-Methoxyethyl Chimeric Antisense Oligonucleotides in Non-Human Primates and Healthy Human Volunteers. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 27357629 DOI: 10.1038/mt.2016.136  0.64
2015 Pandey SK, Wheeler TM, Justice SL, Kim A, Younis HS, Gattis D, Jauvin D, Puymirat J, Swayze EE, Freier SM, Bennett CF, Thornton CA, MacLeod AR. Identification and Characterization of Modified Antisense Oligonucleotides Targeting DMPK in Mice and Nonhuman Primates for the Treatment of Myotonic Dystrophy Type 1. The Journal of Pharmacology and Experimental Therapeutics. 355: 310-21. PMID 26330536 DOI: 10.1124/jpet.115.226969  0.64
2014 Berman CL, Cannon K, Cui Y, Kornbrust DJ, Lagrutta A, Sun SZ, Tepper J, Waldron G, Younis HS. Recommendations for safety pharmacology evaluations of oligonucleotide- based therapeutics Nucleic Acid Therapeutics. 24: 291-301. PMID 24946015 DOI: 10.1089/nat.2013.0477  0.64
2014 Laifenfeld D, Qiu L, Swiss R, Park J, Macoritto M, Will Y, Younis HS, Lawton M. Utilization of causal reasoning of hepatic gene expression in rats to identify molecular pathways of idiosyncratic drug-induced liver injury. Toxicological Sciences : An Official Journal of the Society of Toxicology. 137: 234-48. PMID 24136188 DOI: 10.1093/toxsci/kft232  0.64
2013 Younis HS, Templin M, Whitely LO, Kornbrust D, Kim TW, Henry SP. Overview of the Nonclinical Development Strategies and Class-Effects of Oligonucleotide-Based Therapeutics A Comprehensive Guide to Toxicology in Preclinical Drug Development. 647-664. DOI: 10.1016/B978-0-12-387815-1.00026-5  0.64
2012 Younis HS, Crosby J, Huh JI, Lee HS, Rime S, Monia B, Henry SP. Antisense inhibition of coagulation factor XI prolongs APTT without increased bleeding risk in cynomolgus monkeys. Blood. 119: 2401-8. PMID 22246038 DOI: 10.1182/blood-2011-10-387134  0.64
2011 Zou W, Roth RA, Younis HS, Malle E, Ganey PE. Neutrophil-cytokine interactions in a rat model of sulindac-induced idiosyncratic liver injury. Toxicology. 290: 278-85. PMID 22019926 DOI: 10.1016/j.tox.2011.10.005  0.64
2011 Younis HS, Hirakawa B, Scott W, Tran P, Bhat G, Affolter T, Chapman J, Heyen J, Chakravarty K, Alton G. Antisense inhibition of S6 kinase 1 produces improved glucose tolerance and is well tolerated for 4 weeks of treatment in rats Pharmacology. 87: 11-23. PMID 21178385 DOI: 10.1159/000322526  0.64
2010 Zou W, Roth RA, Younis HS, Burgoon LD, Ganey PE. Oxidative stress is important in the pathogenesis of liver injury induced by sulindac and lipopolysaccharide cotreatment. Toxicology. 272: 32-8. PMID 20371263 DOI: 10.1016/j.tox.2010.03.015  0.64
2009 Huang W, Yang AH, Matsumoto D, Collette W, Marroquin L, Ko M, Aguirre S, Younis HS. PD0325901, a mitogen-activated protein kinase kinase inhibitor, produces ocular toxicity in a rabbit animal model of retinal vein occlusion. Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association For Ocular Pharmacology and Therapeutics. 25: 519-30. PMID 19929595 DOI: 10.1089/jop.2009.0060  0.64
2009 Zou W, Beggs KM, Sparkenbaugh EM, Jones AD, Younis HS, Roth RA, Ganey PE. Sulindac metabolism and synergy with tumor necrosis factor-alpha in a drug-inflammation interaction model of idiosyncratic liver injury. The Journal of Pharmacology and Experimental Therapeutics. 331: 114-21. PMID 19638570 DOI: 10.1124/jpet.109.156331  0.64
2009 Singh SR, Carreiro ST, Chu J, Prasanna G, Niesman MR, Collette Iii WW, Younis HS, Sartnurak S, Gukasyan HJ. L-Carnosine: multifunctional dipeptide buffer for sustained-duration topical ophthalmic formulations. The Journal of Pharmacy and Pharmacology. 61: 733-42. PMID 19505363 DOI: 10.1211/jpp/61.06.0005  0.64
2009 Zou W, Devi SS, Sparkenbaugh E, Younis HS, Roth RA, Ganey PE. Hepatotoxic interaction of sulindac with lipopolysaccharide: role of the hemostatic system. Toxicological Sciences : An Official Journal of the Society of Toxicology. 108: 184-93. PMID 19074762 DOI: 10.1093/toxsci/kfn259  0.64
2008 Younis HS, Shawer M, Palacio K, Gukasyan HJ, Stevens GJ, Evering W. An assessment of the ocular safety of inactive excipients following sub-tenon injection in rabbits. Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association For Ocular Pharmacology and Therapeutics. 24: 206-16. PMID 18345993 DOI: 10.1089/jop.2007.0099  0.64
2006 Younis HS, Vickers T, Levin AA, Henry SP. CpG and Non-CpG oligodeoxynucleotides induce differential proinflammatory gene expression profiles in liver and peripheral blood leukocytes in mice. Journal of Immunotoxicology. 3: 57-68. PMID 18958686 DOI: 10.1080/15476910600718236  0.64
2006 Younis HS, Jessen BA, Wu EY, Stevens GJ. Inhibiting matrix metalloproteinases with prinomastat produces abnormalities in fetal growth and development in rats. Birth Defects Research. Part B, Developmental and Reproductive Toxicology. 77: 95-103. PMID 16607633 DOI: 10.1002/bdrb.20073  0.64
2003 Younis HS, Parrish AR, Glenn Sipes I. The role of hepatocellular oxidative stress in Kupffer cell activation during 1,2-dichlorobenzene-induced hepatotoxicity. Toxicological Sciences : An Official Journal of the Society of Toxicology. 76: 201-11. PMID 12915711 DOI: 10.1093/toxsci/kfg207  0.64
2002 Gailer J, George GN, Pickering IJ, Prince RC, Younis HS, Winzerling JJ. Biliary excretion of [(GS)(2)AsSe](-) after intravenous injection of rabbits with arsenite and selenate. Chemical Research in Toxicology. 15: 1466-71. PMID 12437338 DOI: 10.1021/tx025538s  0.64
2002 Gailer J, Madden S, Buttigieg GA, Bonner Denton M, Younis HS. Identification of [(GS)2AsSe]- in rabbit bile by size-exclusion chromatography and simultaneous multielement-specific detection by inductively coupled plasma atomic emission spectroscopy Applied Organometallic Chemistry. 16: 72-75. DOI: 10.1002/aoc.260  0.64
2000 Gailer J, George GN, Pickering IJ, Madden S, Prince RC, Yu EY, Denton MB, Younis HS, Aposhian HV. Structural basis of the antagonism between inorganic mercury and selenium in mammals. Chemical Research in Toxicology. 13: 1135-42. PMID 11087435 DOI: 10.1021/tx000050h  0.64
2000 Younis HS, Hoglen NC, Kuester RK, Gunawardhana L, Sipes IG. 1,2-Dichlorobenzene-mediated hepatocellular oxidative stress in Fischer-344 and Sprague-Dawley rats. Toxicology and Applied Pharmacology. 163: 141-8. PMID 10698672 DOI: 10.1006/taap.1999.8860  0.64
2000 Gailer J, George GN, Pickering IJ, Prince RC, Ringwald SC, Pemberton JE, Glass RS, Younis HS, DeYoung DW, Aposhian HV. A metabolic link between arsenite and selenite: The seleno-bis(S- glutathionyl) arsinium ion Journal of the American Chemical Society. 122: 4637-4639. DOI: 10.1021/ja993064m  0.64
1999 Parrish AR, Zheng XH, Turney KD, Younis HS, Gandolfi AJ. Enhanced transcription factor DNA binding and gene expression induced by arsenite or arsenate in renal slices. Toxicological Sciences : An Official Journal of the Society of Toxicology. 50: 98-105. PMID 10445758 DOI: 10.1093/toxsci/50.1.98  0.64
1998 Hoglen NC, Younis HS, Hartley DP, Gunawardhana L, Lantz RC, Sipes IG. 1,2-Dichlorobenzene-induced lipid peroxidation in male Fischer 344 rats is Kupffer cell dependent. Toxicological Sciences : An Official Journal of the Society of Toxicology. 46: 376-85. PMID 10048141 DOI: 10.1006/toxs.1998.2523  0.64
1998 Hoglen NC, Regan SP, Hensel JL, Younis HS, Sauer JM, Steup DR, Miller MJ, Waterman SJ, Twerdok LE, Sipes IG. Alteration of Kupffer cell function and morphology by low melt point paraffin wax in female Fischer-344 but not Sprague-Dawley rats. Toxicological Sciences : An Official Journal of the Society of Toxicology. 46: 176-84. PMID 9928681 DOI: 10.1006/toxs.1998.2509  0.64
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