Gregory Thatcher - Publications

Affiliations: 
University of Illinois at Chicago, Chicago, IL, United States 
Area:
Biochemistry

51 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Andreano KJ, Wardell SE, Baker JG, Desautels TK, Baldi R, Chao CA, Heetderks KA, Bae Y, Xiong R, Tonetti DA, Gutgesell LM, Zhao J, Sorrentino JA, Thompson DA, Bisi JE, ... ... Thatcher GRJ, et al. G1T48, an oral selective estrogen receptor degrader, and the CDK4/6 inhibitor lerociclib inhibit tumor growth in animal models of endocrine-resistant breast cancer. Breast Cancer Research and Treatment. PMID 32130619 DOI: 10.1007/S10549-020-05575-9  0.303
2020 O'Regan R, Hurley R, Sachdev J, Bleeker J, Tonetti D, Thatcher G, Venuti R, Dudek A. Abstract P5-11-06: Phase 1 study of TTC-352 in patients with metastatic breast cancer progressing on endocrine therapy Cancer Research. 80. DOI: 10.1158/1538-7445.Sabcs19-P5-11-06  0.325
2019 ORegan RM, Hurley R, Sachdev JC, Bleeker J, Tonetti D, Thatcher G, Venuti R, Dudek AZ. Abstract CT051: Phase I study of TTC-352 in patients with estrogen receptor-positive metastatic breast cancer Cancer Research. 79. DOI: 10.1158/1538-7445.Am2019-Ct051  0.312
2019 Xiong R, Li Y, Zhao J, Tonetti D, Thatcher G. Abstract 3830: Novel bromodomains and extra-terminal motif (BET) inhibitors developed against estrogen receptor positive, fulvestrant- and CDK4/6-resistant breast cancer models Cancer Research. 79: 3830-3830. DOI: 10.1158/1538-7445.Am2019-3830  0.407
2018 Gaisina IN, Lee SH, Kaidery NA, Ben Aissa M, Ahuja M, Smirnova NN, Wakade S, Gaisin A, Bourassa MW, Ratan RR, Nikulin SV, Poloznikov AA, Thomas B, Thatcher GRJ, Gazaryan IG. Activation of Nrf2 and Hypoxic Adaptive Response Contribute to Neuroprotection Elicited by Phenylhydroxamic Acid Selective HDAC6 Inhibitors. Acs Chemical Neuroscience. PMID 29338172 DOI: 10.1021/Acschemneuro.7B00435  0.301
2017 Petukhov PA, Abdelkarim H, Neelarapu R, Madriaga A, Kastrati I, Wang YT, Vaidya AS, Taha TY, Thatcher GRJ, Frasor J. Design, Synthesis, Molecular Modeling, and Biological Evaluation of Novel Amine-based Histone Deacetylase Inhibitors. Chemmedchem. PMID 29080240 DOI: 10.1002/Cmdc.201700449  0.7
2017 Kastrati I, Siklos MI, Brovkovych SD, Thatcher GR, Frasor J. A Novel Strategy to Co-target Estrogen Receptor and Nuclear Factor κB Pathways with Hybrid Drugs for Breast Cancer Therapy. Hormones & Cancer. PMID 28396978 DOI: 10.1007/S12672-017-0294-5  0.743
2017 Kastrati I, Delgado-Rivera L, Georgieva G, Thatcher GR, Frasor J. Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells. Journal of Visualized Experiments : Jove. PMID 28190074 DOI: 10.3791/54798  0.745
2016 Pierce EN, Piyankarage SC, Dunlap TL, Litosh VA, Siklos MI, Wang YT, Thatcher GR. Prodrugs Bioactivated to Quinones Target NF-κB and Multiple Protein Networks: Identification of the Quinonome. Chemical Research in Toxicology. PMID 27258437 DOI: 10.1021/Acs.Chemrestox.6B00115  0.306
2016 Kastrati I, Siklos MI, Calderon-Gierszal EL, El-Shennawy L, Georgieva G, Thayer EN, Thatcher GR, Frasor J. Dimethyl Fumarate Inhibits the Nuclear Factor κB Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein. The Journal of Biological Chemistry. 291: 3639-47. PMID 26683377 DOI: 10.1074/Jbc.M115.679704  0.754
2016 Xiong R, Zhao J, Gutgesell L, Tonetti D, Thatcher G. Abstract 3902: Novel selective estrogen receptor downregulators developed using endocrine-independent breast cancer cell lines Cancer Research. 76: 3902-3902. DOI: 10.1158/1538-7445.Am2016-3902  0.394
2015 Kastrati I, Litosh VA, Zhao S, Alvarez M, Thatcher GR, Frasor J. A novel aspirin prodrug inhibits NFκB activity and breast cancer stem cell properties. Bmc Cancer. 15: 845. PMID 26530254 DOI: 10.1186/S12885-015-1868-7  0.746
2015 Fà M, Zhang H, Staniszewski A, Saeed F, Shen LW, Schiefer IT, Siklos MI, Tapadar S, Litosh VA, Libien J, Petukhov PA, Teich AF, Thatcher GR, Arancio O. Novel Selective Calpain 1 Inhibitors as Potential Therapeutics in Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 26484927 DOI: 10.3233/Jad-150618  0.717
2015 Kastrati I, Siklos M, Litosh V, Thatcher G, Frasor J. Abstract 4497: Design and synthesis of hybrid drugs to target inflammatory pathways in breast cancer Cancer Research. 75: 4497-4497. DOI: 10.1158/1538-7445.Am2015-4497  0.761
2014 Patel HK, Siklos MI, Abdelkarim H, Mendonca EL, Vaidya A, Petukhov PA, Thatcher GR. A chimeric SERM-histone deacetylase inhibitor approach to breast cancer therapy. Chemmedchem. 9: 602-13. PMID 23956109 DOI: 10.1002/Cmdc.201300270  0.302
2013 Schiefer IT, Tapadar S, Litosh V, Siklos M, Scism R, Wijewickrama GT, Chandrasena EP, Sinha V, Tavassoli E, Brunsteiner M, Fa' M, Arancio O, Petukhov P, Thatcher GR. Design, synthesis, and optimization of novel epoxide incorporating peptidomimetics as selective calpain inhibitors. Journal of Medicinal Chemistry. 56: 6054-68. PMID 23834438 DOI: 10.1021/Jm4006719  0.725
2013 Siklos MI, Gandhi RP, Xiong R, Schiefer IT, Litosh V, VandeVrede L, Thatcher GR. Discovery of neuroprotective soluble guanylate cyclase modulators (GCMs) aciting via NO/GC/cGMP/CREB pathway Bmc Pharmacology and Toxicology. 14. DOI: 10.1186/2050-6511-14-S1-P65  0.732
2012 Dunlap T, Piyankarage SC, Wijewickrama GT, Abdul-Hay S, Vanni M, Litosh V, Luo J, Thatcher GR. Quinone-induced activation of Keap1/Nrf2 signaling by aspirin prodrugs masquerading as nitric oxide. Chemical Research in Toxicology. 25: 2725-36. PMID 23035985 DOI: 10.1021/Tx3003609  0.751
2012 Schiefer IT, VandeVrede L, Fa' M, Arancio O, Thatcher GR. Furoxans (1,2,5-oxadiazole-N-oxides) as novel NO mimetic neuroprotective and procognitive agents. Journal of Medicinal Chemistry. 55: 3076-87. PMID 22429006 DOI: 10.1021/Jm201504S  0.734
2012 Hemachandra LPMP, Choi J, Bolotn J, Thatcher G. Abstract LB-64: Selective estrogen receptor modulators (SERMs) act as breast cancer chemopreventive agents by attenuating oxidative estrogen metabolism Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Lb-64  0.41
2011 Kastrati I, Edirisinghe PD, Hemachandra LP, Chandrasena ER, Choi J, Wang YT, Bolton JL, Thatcher GR. Raloxifene and desmethylarzoxifene block estrogen-induced malignant transformation of human breast epithelial cells. Plos One. 6: e27876. PMID 22140478 DOI: 10.1371/Journal.Pone.0027876  0.718
2011 Abdul-Hay S, Schiefer IT, Chandrasena RE, Li M, Abdelhamid R, Wang YT, Tavassoli E, Michalsen B, Asghodom RT, Luo J, Thatcher GR. NO-SSRIs: Nitric Oxide Chimera Drugs Incorporating a Selective Serotonin Reuptake Inhibitor. Acs Medicinal Chemistry Letters. 2: 656-661. PMID 21927645 DOI: 10.1021/Ml2000033  0.769
2011 Abdelhamid R, Luo J, Vandevrede L, Kundu I, Michalsen B, Litosh VA, Schiefer IT, Gherezghiher T, Yao P, Qin Z, Thatcher GR. Benzothiophene Selective Estrogen Receptor Modulators Provide Neuroprotection by a novel GPR30-dependent Mechanism. Acs Chemical Neuroscience. 2: 256-268. PMID 21731800 DOI: 10.1021/Cn100106A  0.752
2011 Schiefer IT, Abdul-Hay S, Wang H, Vanni M, Qin Z, Thatcher GR. Inhibition of amyloidogenesis by nonsteroidal anti-inflammatory drugs and their hybrid nitrates. Journal of Medicinal Chemistry. 54: 2293-306. PMID 21405086 DOI: 10.1021/Jm101450P  0.783
2010 Kastrati I, Edirisinghe PD, Wijewickrama GT, Thatcher GR. Estrogen-induced apoptosis of breast epithelial cells is blocked by NO/cGMP and mediated by extranuclear estrogen receptors. Endocrinology. 151: 5602-16. PMID 20943808 DOI: 10.1210/En.2010-0378  0.718
2010 Peng KW, Chang M, Wang YT, Wang Z, Qin Z, Bolton JL, Thatcher GR. Unexpected hormonal activity of a catechol equine estrogen metabolite reveals reversible glutathione conjugation. Chemical Research in Toxicology. 23: 1374-83. PMID 20540524 DOI: 10.1021/Tx100129H  0.315
2010 Sinha V, Wijewickrama GT, Chandrasena RE, Xu H, Edirisinghe PD, Schiefer IT, Thatcher GR. Proteomic and mass spectroscopic quantitation of protein S-nitrosation differentiates NO-donors. Acs Chemical Biology. 5: 667-80. PMID 20524644 DOI: 10.1021/Cb100054M  0.695
2010 Anand S, Schiefer IT, Thatcher GRJ. Nitric oxide donor and mimetic molecules in cancer chemotherapy and chemoprevention Forum On Immunopathological Diseases and Therapeutics. 1: 251-279. DOI: 10.1615/Forumimmundisther.V1.I4.20  0.708
2009 Abdul-Hay SO, Edirisinghe P, Thatcher GR. Selective modulation of amyloid-beta peptide degradation by flurbiprofen, fenofibrate, and related compounds regulates Abeta levels. Journal of Neurochemistry. 111: 683-95. PMID 19702658 DOI: 10.1111/j.1471-4159.2009.06355.x  0.706
2009 Abdul-Hay SO, Luo J, Ashghodom RT, Thatcher GR. NO-flurbiprofen reduces amyloid-beta, is neuroprotective in cell culture, and enhances cognition in response to cholinergic blockade. Journal of Neurochemistry. 111: 766-76. PMID 19702655 DOI: 10.1111/j.1471-4159.2009.06353.x  0.748
2009 Chirapu SR, Pachaiyappan B, Nural HF, Cheng X, Yuan H, Lankin DC, Abdul-Hay SO, Thatcher GR, Shen Y, Kozikowski AP, Petukhov PA. Molecular modeling, synthesis, and activity studies of novel biaryl and fused-ring BACE1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 264-74. PMID 19013792 DOI: 10.1016/J.Bmcl.2008.10.096  0.729
2009 Qin Z, Kastrati I, Ashgodom RT, Lantvit DD, Overk CR, Choi Y, van Breemen RB, Bolton JL, Thatcher GR. Structural modulation of oxidative metabolism in design of improved benzothiophene selective estrogen receptor modulators. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 161-9. PMID 18936111 DOI: 10.1124/Dmd.108.023408  0.707
2009 Molloy M, Thatcher G, Bolton J, Tonetti D. 2-(4-Hydroxyphenyl)-Benzo[b]thiophen-6-ol, an Estrogen-Like Compound, Induces Apoptosis in T47D/PKCα Breast Cancer Cells. Cancer Research. 69: 5140-5140. DOI: 10.1158/0008-5472.Sabcs-09-5140  0.399
2008 Hagos GK, Abdul-Hay SO, Sohn J, Edirisinghe PD, Chandrasena RE, Wang Z, Li Q, Thatcher GR. Anti-inflammatory, antiproliferative, and cytoprotective activity of NO chimera nitrates of use in cancer chemoprevention. Molecular Pharmacology. 74: 1381-91. PMID 18676677 DOI: 10.1124/Mol.108.046664  0.774
2008 Chang M, Overk CR, Kastrati I, Peng KW, Yao P, Qin ZH, Petukhov P, Bolton JL, Thatcher GR. Estrogenic activity of the equine estrogen metabolite, 4-methoxyequilenin. Advances in Experimental Medicine and Biology. 617: 601-7. PMID 18497087 DOI: 10.1007/978-0-387-69080-3_62  0.71
2008 Dunlap T, Abdul-Hay SO, Chandrasena RE, Hagos GK, Sinha V, Wang Z, Wang H, Thatcher GR. Nitrates and NO-NSAIDs in cancer chemoprevention and therapy: in vitro evidence querying the NO donor functionality. Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. 19: 115-24. PMID 18485921 DOI: 10.1016/J.Niox.2008.04.013  0.778
2007 Dunlap T, Chandrasena RE, Wang Z, Sinha V, Wang Z, Thatcher GR. Quinone formation as a chemoprevention strategy for hybrid drugs: balancing cytotoxicity and cytoprotection. Chemical Research in Toxicology. 20: 1903-12. PMID 17975886 DOI: 10.1021/Tx7002257  0.343
2007 Yu B, Dietz BM, Dunlap T, Kastrati I, Lantvit DD, Overk CR, Yao P, Qin Z, Bolton JL, Thatcher GR. Structural modulation of reactivity/activity in design of improved benzothiophene selective estrogen receptor modulators: induction of chemopreventive mechanisms. Molecular Cancer Therapeutics. 6: 2418-28. PMID 17876041 DOI: 10.1158/1535-7163.Mct-07-0268  0.749
2007 Hagos GK, Carroll RE, Kouznetsova T, Li Q, Toader V, Fernandez PA, Swanson SM, Thatcher GR. Colon cancer chemoprevention by a novel NO chimera that shows anti-inflammatory and antiproliferative activity in vitro and in vivo. Molecular Cancer Therapeutics. 6: 2230-9. PMID 17699720 DOI: 10.1158/1535-7163.Mct-07-0069  0.8
2007 Overk CR, Peng KW, Asghodom RT, Kastrati I, Lantvit DD, Qin Z, Frasor J, Bolton JL, Thatcher GR. Structure-activity relationships for a family of benzothiophene selective estrogen receptor modulators including raloxifene and arzoxifene. Chemmedchem. 2: 1520-6. PMID 17654759 DOI: 10.1002/Cmdc.200700104  0.726
2007 Chang M, Peng KW, Kastrati I, Overk CR, Qin ZH, Yao P, Bolton JL, Thatcher GR. Activation of estrogen receptor-mediated gene transcription by the equine estrogen metabolite, 4-methoxyequilenin, in human breast cancer cells. Endocrinology. 148: 4793-802. PMID 17584965 DOI: 10.1210/En.2006-1568  0.718
2007 Qin Z, Kastrati I, Chandrasena RE, Liu H, Yao P, Petukhov PA, Bolton JL, Thatcher GR. Benzothiophene selective estrogen receptor modulators with modulated oxidative activity and receptor affinity. Journal of Medicinal Chemistry. 50: 2682-92. PMID 17489582 DOI: 10.1021/Jm070079J  0.723
2006 Clarke JL, Kastrati I, Johnston LJ, Thatcher GRJ. Photochemical reactions of thiols with organic nitrates - Oxygen atom transfer via a thionitrate Canadian Journal of Chemistry. 84: 709-719. DOI: 10.1139/V06-056  0.671
2005 Liu J, Liu H, van Breemen RB, Thatcher GR, Bolton JL. Bioactivation of the selective estrogen receptor modulator acolbifene to quinone methides. Chemical Research in Toxicology. 18: 174-82. PMID 15720121 DOI: 10.1021/Tx0497752  0.311
2005 Liu H, Liu J, van Breemen RB, Thatcher GR, Bolton JL. Bioactivation of the selective estrogen receptor modulator desmethylated arzoxifene to quinoids: 4'-fluoro substitution prevents quinoid formation. Chemical Research in Toxicology. 18: 162-73. PMID 15720120 DOI: 10.1021/Tx049776U  0.338
1987 Kluger R, Thatcher GRJ, Stallings WC. Synthesis, structure, and hydrolysis of esters of strained and unstrained N-phosphonylureas Canadian Journal of Chemistry. 65: 1838-1844.  0.454
1986 Thatcher GRJ, Poirier R, Kluger R. Enzymic carboxyl transfer from N-carboxybiotin. A molecular orbital evaluation of conformational effects in promoting reactivity Journal of the American Chemical Society®. 108: 2699-2704. DOI: 10.1021/Ja00270A031  0.452
1986 THATCHER GRJ, POIRIER R, KLUGER R. ChemInform Abstract: Enzymic Carboxyl Transfer from N-Carboxybiotin. A MO Evaluation of Conformational Effects in Promoting Reactivity. Chemischer Informationsdienst. 17. DOI: 10.1002/Chin.198637071  0.451
1986 KLUGER R, THATCHER GRJ. ChemInform Abstract: Exocyclic Cleavage in the Alkaline Hydrolysis of Methyl Ethylene Phosphate. Chemischer Informationsdienst. 17. DOI: 10.1002/chin.198605239  0.426
1986 Kluger R, Thatcher GRJ. Exocyclic cleavage in the alkaline hydrolysis of methyl ethylene phosphate: Pseudorotation of a pentavalent intermediate or reaction via a hexavalent intermediate? Journal of Organic Chemistry. 51: 207-212.  0.455
1985 Kluger R, Thatcher GRJ. Exocyclic cleavage in the alkaline hydrolysis of methyl ethylene phosphate. Evidence against the significance of stereoelectronic acceleration in reactions of cyclic phosphates Journal of the American Chemical Society. 107: 6006-6011.  0.453
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