Gregory Thatcher - Publications

Affiliations: 
University of Illinois at Chicago, Chicago, IL, United States 
Area:
Biochemistry

132 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Yao Y, Delgado-Rivera L, Samareh Afsari H, Yin L, Thatcher GRJ, Moore TW, Miller LW. Time-Gated Luminescence Detection of Enzymatically Produced Hydrogen Sulfide: Design, Synthesis, and Application of a Lanthanide-Based Probe. Inorganic Chemistry. PMID 29281273 DOI: 10.1021/acs.inorgchem.7b02533  0.4
2017 Bhattacharjee A, Sinha A, Ratia K, Yin L, Delgado-Rivera L, Petukhov PA, Thatcher GRJ, Wardrop DJ. 2-Arylidene Hydrazinecarbodithioates as Potent, Selective Inhibitors of Cystathionine γ-Lyase (CSE). Acs Medicinal Chemistry Letters. 8: 1241-1245. PMID 29259741 DOI: 10.1021/acsmedchemlett.7b00313  0.4
2017 Petukhov PA, Abdelkarim H, Neelarapu R, Madriaga A, Kastrati I, Wang YT, Vaidya AS, Taha TY, Thatcher GRJ, Frasor J. Design, Synthesis, Molecular Modeling, and Biological Evaluation of Novel Amine-based Histone Deacetylase Inhibitors. Chemmedchem. PMID 29080240 DOI: 10.1002/cmdc.201700449  0.76
2017 Kastrati I, Siklos MI, Brovkovych SD, Thatcher GR, Frasor J. A Novel Strategy to Co-target Estrogen Receptor and Nuclear Factor κB Pathways with Hybrid Drugs for Breast Cancer Therapy. Hormones & Cancer. PMID 28396978 DOI: 10.1007/s12672-017-0294-5  0.76
2017 Kastrati I, Delgado-Rivera L, Georgieva G, Thatcher GR, Frasor J. Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells. Journal of Visualized Experiments : Jove. PMID 28190074 DOI: 10.3791/54798  0.76
2016 Pierce EN, Piyankarage SC, Dunlap TL, Litosh VA, Siklos MI, Wang YT, Thatcher GR. Prodrugs Bioactivated to Quinones Target NF-κB and Multiple Protein Networks: Identification of the Quinonome. Chemical Research in Toxicology. PMID 27258437 DOI: 10.1021/acs.chemrestox.6b00115  0.68
2016 Luo J, Lee SH, VandeVrede L, Qin Z, Aissa MB, Larson J, Teich AF, Arancio O, D'Souza Y, Elharram A, Koster K, Tai LM, LaDu MJ, Bennett BM, Thatcher GR. Erratum to: A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer's disease. Molecular Neurodegeneration. 11: 40. PMID 27194246 DOI: 10.1186/s13024-016-0104-5  0.52
2016 Luo J, Lee SH, VandeVrede L, Qin Z, Ben Aissa M, Larson J, Teich AF, Arancio O, D'Souza Y, Elharram A, Koster K, Tai LM, LaDu MJ, Bennett BM, Thatcher GR. A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer's disease. Molecular Neurodegeneration. 11: 35. PMID 27129593 DOI: 10.1186/s13024-016-0103-6  0.52
2016 Kastrati I, Siklos MI, Calderon-Gierszal EL, El-Shennawy L, Georgieva G, Thayer EN, Thatcher GR, Frasor J. Dimethyl Fumarate Inhibits the Nuclear Factor κB Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein. The Journal of Biological Chemistry. 291: 3639-47. PMID 26683377 DOI: 10.1074/jbc.M115.679704  0.68
2016 Wang YT, Piyankarage SC, Thatcher GRJ. Quantitative profiling of reversible cysteome modification under nitrosative stress Neuromethods. 114: 55-72. DOI: 10.1007/7657_2015_88  0.68
2015 Siklos M, BenAissa M, Thatcher GR. Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors. Acta Pharmaceutica Sinica. B. 5: 506-19. PMID 26713267 DOI: 10.1016/j.apsb.2015.08.001  0.68
2015 Xiong R, Patel HK, Gutgesell LM, Zhao J, Delgado-Rivera L, Pham TN, Zhao H, Carlson KE, Martin TA, Katzenellenbogen JA, Moore TW, Tonetti D, Thatcher GR. Selective human Estrogen Receptor Partial Agonists (ShERPAs) for Tamoxifen-Resistant Breast Cancer. Journal of Medicinal Chemistry. PMID 26681208 DOI: 10.1021/acs.jmedchem.5b01276  0.68
2015 Kastrati I, Litosh VA, Zhao S, Alvarez M, Thatcher GR, Frasor J. A novel aspirin prodrug inhibits NFκB activity and breast cancer stem cell properties. Bmc Cancer. 15: 845. PMID 26530254 DOI: 10.1186/s12885-015-1868-7  0.68
2015 Fà M, Zhang H, Staniszewski A, Saeed F, Shen LW, Schiefer IT, Siklos MI, Tapadar S, Litosh VA, Libien J, Petukhov PA, Teich AF, Thatcher GR, Arancio O. Novel Selective Calpain 1 Inhibitors as Potential Therapeutics in Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 26484927 DOI: 10.3233/JAD-150618  0.68
2015 Luo J, Lee SH, VandeVrede L, Qin Z, Piyankarage S, Tavassoli E, Asghodom RT, Aissa MB, Fà M, Arancio O, Yue L, Pepperberg DR, Thatcher GR. Re-engineering a neuroprotective, clinical drug as a procognitive agent with high in vivo potency and with GABAA potentiating activity for use in dementia. Bmc Neuroscience. 16: 67. PMID 26480871 DOI: 10.1186/s12868-015-0208-9  0.68
2014 Tai LM, Koster KP, Luo J, Lee SH, Wang YT, Collins NC, Ben Aissa M, Thatcher GR, LaDu MJ. Amyloid-β pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo. The Journal of Biological Chemistry. 289: 30538-55. PMID 25217640 DOI: 10.1074/jbc.M114.600833  0.68
2014 Hemachandra LP, Patel H, Chandrasena RE, Choi J, Piyankarage SC, Wang S, Wang Y, Thayer EN, Scism RA, Michalsen BT, Xiong R, Siklos MI, Bolton JL, Thatcher GR. SERMs attenuate estrogen-induced malignant transformation of human mammary epithelial cells by upregulating detoxification of oxidative metabolites. Cancer Prevention Research (Philadelphia, Pa.). 7: 505-15. PMID 24598415 DOI: 10.1158/1940-6207.CAPR-13-0296  0.68
2014 Wang YT, Piyankarage SC, Williams DL, Thatcher GR. Proteomic profiling of nitrosative stress: protein S-oxidation accompanies S-nitrosylation. Acs Chemical Biology. 9: 821-30. PMID 24397869 DOI: 10.1021/cb400547u  0.68
2014 Vandevrede L, Tavassoli E, Luo J, Qin Z, Yue L, Pepperberg DR, Thatcher GR. Novel analogues of chlormethiazole are neuroprotective in four cellular models of neurodegeneration by a mechanism with variable dependence on GABA(A) receptor potentiation. British Journal of Pharmacology. 171: 389-402. PMID 24116891 DOI: 10.1111/bph.12454  0.68
2014 Patel HK, Siklos MI, Abdelkarim H, Mendonca EL, Vaidya A, Petukhov PA, Thatcher GR. A chimeric SERM-histone deacetylase inhibitor approach to breast cancer therapy. Chemmedchem. 9: 602-13. PMID 23956109 DOI: 10.1002/cmdc.201300270  0.68
2014 Nicolescu AC, Thatcher GRJ. Differential activation of soluble guanylate cyclase by a series of aryl disulfanyl dinitrate esters Medchemcomm. 5: 51-56. DOI: 10.1039/c3md00261f  0.68
2013 VandeVrede L, Abdelhamid R, Qin Z, Choi J, Piyankarage S, Luo J, Larson J, Bennett BM, Thatcher GR. An NO donor approach to neuroprotective and procognitive estrogen therapy overcomes loss of NO synthase function and potentially thrombotic risk. Plos One. 8: e70740. PMID 23976955 DOI: 10.1371/journal.pone.0070740  0.68
2013 Schiefer IT, Tapadar S, Litosh V, Siklos M, Scism R, Wijewickrama GT, Chandrasena EP, Sinha V, Tavassoli E, Brunsteiner M, Fa' M, Arancio O, Petukhov P, Thatcher GR. Design, synthesis, and optimization of novel epoxide incorporating peptidomimetics as selective calpain inhibitors. Journal of Medicinal Chemistry. 56: 6054-68. PMID 23834438 DOI: 10.1021/jm4006719  0.68
2012 Dunlap T, Piyankarage SC, Wijewickrama GT, Abdul-Hay S, Vanni M, Litosh V, Luo J, Thatcher GR. Quinone-induced activation of Keap1/Nrf2 signaling by aspirin prodrugs masquerading as nitric oxide. Chemical Research in Toxicology. 25: 2725-36. PMID 23035985 DOI: 10.1021/tx3003609  0.68
2012 Qin Z, Luo J, VandeVrede L, Tavassoli E, Fa' M, Teich AF, Arancio O, Thatcher GR. Design and synthesis of neuroprotective methylthiazoles and modification as NO-chimeras for neurodegenerative therapy. Journal of Medicinal Chemistry. 55: 6784-801. PMID 22779770 DOI: 10.1021/jm300353r  0.68
2012 Michalsen BT, Gherezghiher TB, Choi J, Chandrasena RE, Qin Z, Thatcher GR, Bolton JL. Selective estrogen receptor modulator (SERM) lasofoxifene forms reactive quinones similar to estradiol. Chemical Research in Toxicology. 25: 1472-83. PMID 22642258 DOI: 10.1021/tx300142h  0.68
2012 Schiefer IT, VandeVrede L, Fa' M, Arancio O, Thatcher GR. Furoxans (1,2,5-oxadiazole-N-oxides) as novel NO mimetic neuroprotective and procognitive agents. Journal of Medicinal Chemistry. 55: 3076-87. PMID 22429006 DOI: 10.1021/jm201504s  0.68
2012 Hickok JR, Vasudevan D, Thatcher GR, Thomas DD. Is S-nitrosocysteine a true surrogate for nitric oxide? Antioxidants & Redox Signaling. 17: 962-8. PMID 22304688 DOI: 10.1089/ars.2012.4543  0.68
2012 Gherezghiher TB, Michalsen B, Chandrasena RE, Qin Z, Sohn J, Thatcher GR, Bolton JL. The naphthol selective estrogen receptor modulator (SERM), LY2066948, is oxidized to an o-quinone analogous to the naphthol equine estrogen, equilenin. Chemico-Biological Interactions. 196: 1-10. PMID 22290292 DOI: 10.1016/j.cbi.2012.01.004  0.68
2012 Hemachandra LP, Madhubhani P, Chandrasena R, Esala P, Chen SN, Main M, Lankin DC, Scism RA, Dietz BM, Pauli GF, Thatcher GR, Bolton JL. Hops (Humulus lupulus) inhibits oxidative estrogen metabolism and estrogen-induced malignant transformation in human mammary epithelial cells (MCF-10A). Cancer Prevention Research (Philadelphia, Pa.). 5: 73-81. PMID 21997247 DOI: 10.1158/1940-6207.CAPR-11-0348  0.68
2012 Overk CR, Lu PY, Wang YT, Choi J, Shaw JW, Thatcher GR, Mufson EJ. Effects of aromatase inhibition versus gonadectomy on hippocampal complex amyloid pathology in triple transgenic mice. Neurobiology of Disease. 45: 479-87. PMID 21945538 DOI: 10.1016/j.nbd.2011.08.035  0.68
2011 Kastrati I, Edirisinghe PD, Hemachandra LP, Chandrasena ER, Choi J, Wang YT, Bolton JL, Thatcher GR. Raloxifene and desmethylarzoxifene block estrogen-induced malignant transformation of human breast epithelial cells. Plos One. 6: e27876. PMID 22140478 DOI: 10.1371/journal.pone.0027876  0.68
2011 Abdul-Hay S, Schiefer IT, Chandrasena RE, Li M, Abdelhamid R, Wang YT, Tavassoli E, Michalsen B, Asghodom RT, Luo J, Thatcher GR. NO-SSRIs: Nitric Oxide Chimera Drugs Incorporating a Selective Serotonin Reuptake Inhibitor. Acs Medicinal Chemistry Letters. 2: 656-661. PMID 21927645 DOI: 10.1021/ml2000033  0.68
2011 Abdelhamid R, Luo J, Vandevrede L, Kundu I, Michalsen B, Litosh VA, Schiefer IT, Gherezghiher T, Yao P, Qin Z, Thatcher GR. Benzothiophene Selective Estrogen Receptor Modulators Provide Neuroprotection by a novel GPR30-dependent Mechanism. Acs Chemical Neuroscience. 2: 256-268. PMID 21731800 DOI: 10.1021/cn100106a  0.52
2011 Schiefer IT, Abdul-Hay S, Wang H, Vanni M, Qin Z, Thatcher GR. Inhibition of amyloidogenesis by nonsteroidal anti-inflammatory drugs and their hybrid nitrates. Journal of Medicinal Chemistry. 54: 2293-306. PMID 21405086 DOI: 10.1021/jm101450p  0.68
2011 Pathi SS, Jutooru I, Chadalapaka G, Sreevalsan S, Anand S, Thatcher GR, Safe S. GT-094, a NO-NSAID, inhibits colon cancer cell growth by activation of a reactive oxygen species-microRNA-27a: ZBTB10-specificity protein pathway. Molecular Cancer Research : McR. 9: 195-202. PMID 21156786 DOI: 10.1158/1541-7786.MCR-10-0363  0.68
2010 Kastrati I, Edirisinghe PD, Wijewickrama GT, Thatcher GR. Estrogen-induced apoptosis of breast epithelial cells is blocked by NO/cGMP and mediated by extranuclear estrogen receptors. Endocrinology. 151: 5602-16. PMID 20943808 DOI: 10.1210/en.2010-0378  0.68
2010 Peng KW, Chang M, Wang YT, Wang Z, Qin Z, Bolton JL, Thatcher GR. Unexpected hormonal activity of a catechol equine estrogen metabolite reveals reversible glutathione conjugation. Chemical Research in Toxicology. 23: 1374-83. PMID 20540524 DOI: 10.1021/tx100129h  0.68
2010 Sinha V, Wijewickrama GT, Chandrasena RE, Xu H, Edirisinghe PD, Schiefer IT, Thatcher GR. Proteomic and mass spectroscopic quantitation of protein S-nitrosation differentiates NO-donors. Acs Chemical Biology. 5: 667-80. PMID 20524644 DOI: 10.1021/cb100054m  0.68
2010 Wang Z, Chandrasena ER, Yuan Y, Peng KW, van Breemen RB, Thatcher GR, Bolton JL. Redox cycling of catechol estrogens generating apurinic/apyrimidinic sites and 8-oxo-deoxyguanosine via reactive oxygen species differentiates equine and human estrogens. Chemical Research in Toxicology. 23: 1365-73. PMID 20509668 DOI: 10.1021/tx1001282  0.68
2010 Kim HY, Sohn J, Wijewickrama GT, Edirisinghe P, Gherezghiher T, Hemachandra M, Lu PY, Chandrasena RE, Molloy ME, Tonetti DA, Thatcher GR. Click synthesis of estradiol-cyclodextrin conjugates as cell compartment selective estrogens. Bioorganic & Medicinal Chemistry. 18: 809-21. PMID 20031420 DOI: 10.1016/j.bmc.2009.11.046  0.68
2010 Anand S, Schiefer IT, Thatcher GRJ. Nitric oxide donor and mimetic molecules in cancer chemotherapy and chemoprevention Forum On Immunopathological Diseases and Therapeutics. 1: 251-279. DOI: 10.1615/ForumImmunDisTher.v1.i4.20  0.68
2010 Bolton JL, Thatcher GRJ. Genotoxic Estrogen Pathway: Endogenous and Equine Estrogen Hormone Replacement Therapy The Chemical Biology of Dna Damage. 185-199. DOI: 10.1002/9783527630110.ch8  0.68
2009 Peng KW, Wang H, Qin Z, Wijewickrama GT, Lu M, Wang Z, Bolton JL, Thatcher GR. Selective estrogen receptor modulator delivery of quinone warheads to DNA triggering apoptosis in breast cancer cells. Acs Chemical Biology. 4: 1039-49. PMID 19839584 DOI: 10.1021/cb9001848  0.68
2009 Abdul-Hay SO, Edirisinghe P, Thatcher GR. Selective modulation of amyloid-beta peptide degradation by flurbiprofen, fenofibrate, and related compounds regulates Abeta levels. Journal of Neurochemistry. 111: 683-95. PMID 19702658 DOI: 10.1111/j.1471-4159.2009.06355.x  0.68
2009 Abdul-Hay SO, Luo J, Ashghodom RT, Thatcher GR. NO-flurbiprofen reduces amyloid-beta, is neuroprotective in cell culture, and enhances cognition in response to cholinergic blockade. Journal of Neurochemistry. 111: 766-76. PMID 19702655 DOI: 10.1111/j.1471-4159.2009.06353.x  0.68
2009 Wang Z, Edirisinghe P, Sohn J, Qin Z, Geacintov NE, Thatcher GR, Bolton JL. Development of a liquid chromatography electrospray ionization tandem mass spectrometry method for analysis of stable 4-hydroxyequilenin-DNA adducts in human breast cancer cells. Chemical Research in Toxicology. 22: 1129-36. PMID 19368368 DOI: 10.1021/tx900063g  0.68
2009 Yu B, Qin Z, Wijewickrama GT, Edirisinghe P, Bolton JL, Thatcher GR. Comparative methods for analysis of protein covalent modification by electrophilic quinoids formed from xenobiotics. Bioconjugate Chemistry. 20: 728-41. PMID 19301905 DOI: 10.1021/bc800435m  0.68
2009 Wang Z, Wijewickrama GT, Peng KW, Dietz BM, Yuan L, van Breemen RB, Bolton JL, Thatcher GR. Estrogen Receptor {alpha} Enhances the Rate of Oxidative DNA Damage by Targeting an Equine Estrogen Catechol Metabolite to the Nucleus. The Journal of Biological Chemistry. 284: 8633-42. PMID 19158089 DOI: 10.1074/jbc.M807860200  0.68
2009 Chirapu SR, Pachaiyappan B, Nural HF, Cheng X, Yuan H, Lankin DC, Abdul-Hay SO, Thatcher GR, Shen Y, Kozikowski AP, Petukhov PA. Molecular modeling, synthesis, and activity studies of novel biaryl and fused-ring BACE1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 264-74. PMID 19013792 DOI: 10.1016/j.bmcl.2008.10.096  0.68
2009 Qin Z, Kastrati I, Ashgodom RT, Lantvit DD, Overk CR, Choi Y, van Breemen RB, Bolton JL, Thatcher GR. Structural modulation of oxidative metabolism in design of improved benzothiophene selective estrogen receptor modulators. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 161-9. PMID 18936111 DOI: 10.1124/dmd.108.023408  0.68
2008 Hagos GK, Abdul-Hay SO, Sohn J, Edirisinghe PD, Chandrasena RE, Wang Z, Li Q, Thatcher GR. Anti-inflammatory, antiproliferative, and cytoprotective activity of NO chimera nitrates of use in cancer chemoprevention. Molecular Pharmacology. 74: 1381-91. PMID 18676677 DOI: 10.1124/mol.108.046664  0.68
2008 Chandrasena RE, Edirisinghe PD, Bolton JL, Thatcher GR. Problematic detoxification of estrogen quinones by NAD(P)H-dependent quinone oxidoreductase and glutathione-S-transferase. Chemical Research in Toxicology. 21: 1324-9. PMID 18588320 DOI: 10.1021/tx8000797  0.68
2008 Chang M, Overk CR, Kastrati I, Peng KW, Yao P, Qin ZH, Petukhov P, Bolton JL, Thatcher GR. Estrogenic activity of the equine estrogen metabolite, 4-methoxyequilenin. Advances in Experimental Medicine and Biology. 617: 601-7. PMID 18497087 DOI: 10.1007/978-0-387-69080-3_62  0.68
2008 Dunlap T, Abdul-Hay SO, Chandrasena RE, Hagos GK, Sinha V, Wang Z, Wang H, Thatcher GR. Nitrates and NO-NSAIDs in cancer chemoprevention and therapy: in vitro evidence querying the NO donor functionality. Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. 19: 115-24. PMID 18485921 DOI: 10.1016/j.niox.2008.04.013  0.68
2008 Bolton JL, Thatcher GR. Potential mechanisms of estrogen quinone carcinogenesis. Chemical Research in Toxicology. 21: 93-101. PMID 18052105 DOI: 10.1021/tx700191p  0.68
2007 Dunlap T, Chandrasena RE, Wang Z, Sinha V, Wang Z, Thatcher GR. Quinone formation as a chemoprevention strategy for hybrid drugs: balancing cytotoxicity and cytoprotection. Chemical Research in Toxicology. 20: 1903-12. PMID 17975886 DOI: 10.1021/tx7002257  0.68
2007 Yu B, Dietz BM, Dunlap T, Kastrati I, Lantvit DD, Overk CR, Yao P, Qin Z, Bolton JL, Thatcher GR. Structural modulation of reactivity/activity in design of improved benzothiophene selective estrogen receptor modulators: induction of chemopreventive mechanisms. Molecular Cancer Therapeutics. 6: 2418-28. PMID 17876041 DOI: 10.1158/1535-7163.MCT-07-0268  0.68
2007 Hagos GK, Carroll RE, Kouznetsova T, Li Q, Toader V, Fernandez PA, Swanson SM, Thatcher GR. Colon cancer chemoprevention by a novel NO chimera that shows anti-inflammatory and antiproliferative activity in vitro and in vivo. Molecular Cancer Therapeutics. 6: 2230-9. PMID 17699720 DOI: 10.1158/1535-7163.MCT-07-0069  0.68
2007 Overk CR, Peng KW, Asghodom RT, Kastrati I, Lantvit DD, Qin Z, Frasor J, Bolton JL, Thatcher GR. Structure-activity relationships for a family of benzothiophene selective estrogen receptor modulators including raloxifene and arzoxifene. Chemmedchem. 2: 1520-6. PMID 17654759 DOI: 10.1002/cmdc.200700104  0.68
2007 Liu H, Qin Z, Thatcher GR, Bolton JL. Uterine peroxidase-catalyzed formation of diquinone methides from the selective estrogen receptor modulators raloxifene and desmethylated arzoxifene. Chemical Research in Toxicology. 20: 1676-84. PMID 17630709 DOI: 10.1021/tx7001367  0.68
2007 May M, Mehboob S, Mulhearn DC, Wang Z, Yu H, Thatcher GR, Santarsiero BD, Johnson ME, Mesecar AD. Structural and functional analysis of two glutamate racemase isozymes from Bacillus anthracis and implications for inhibitor design. Journal of Molecular Biology. 371: 1219-37. PMID 17610893 DOI: 10.1016/j.jmb.2007.05.093  0.68
2007 Chang M, Peng KW, Kastrati I, Overk CR, Qin ZH, Yao P, Bolton JL, Thatcher GR. Activation of estrogen receptor-mediated gene transcription by the equine estrogen metabolite, 4-methoxyequilenin, in human breast cancer cells. Endocrinology. 148: 4793-802. PMID 17584965 DOI: 10.1210/en.2006-1568  0.68
2007 Qin Z, Kastrati I, Chandrasena RE, Liu H, Yao P, Petukhov PA, Bolton JL, Thatcher GR. Benzothiophene selective estrogen receptor modulators with modulated oxidative activity and receptor affinity. Journal of Medicinal Chemistry. 50: 2682-92. PMID 17489582 DOI: 10.1021/jm070079j  0.68
2007 Bennett BM, Reynolds JN, Prusky GT, Douglas RM, Sutherland RJ, Thatcher GR. Cognitive deficits in rats after forebrain cholinergic depletion are reversed by a novel NO mimetic nitrate ester. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 505-13. PMID 16525416 DOI: 10.1038/sj.npp.1301054  0.68
2007 Thatcher GRJ. Organic nitrates and nitrites as stores of NO bioactivity Radicals For Life: the Various Forms of Nitric Oxide. 347-380. DOI: 10.1016/B978-044452236-8/50017-4  0.68
2006 Dowers TS, Qin ZH, Thatcher GR, Bolton JL. Bioactivation of Selective Estrogen Receptor Modulators (SERMs). Chemical Research in Toxicology. 19: 1125-37. PMID 16978016 DOI: 10.1021/tx060126v  0.68
2006 Thatcher GR, Bennett BM, Reynolds JN. NO chimeras as therapeutic agents in Alzheimer's disease. Current Alzheimer Research. 3: 237-45. PMID 16842101 DOI: 10.2174/156720506777632925  0.68
2006 Liu H, Bolton JL, Thatcher GR. Chemical modification modulates estrogenic activity, oxidative reactivity, and metabolic stability in 4'F-DMA, a new benzothiophene selective estrogen receptor modulator. Chemical Research in Toxicology. 19: 779-87. PMID 16780356 DOI: 10.1021/tx050326r  0.68
2006 Nicolescu AC, Li Q, Brown L, Thatcher GR. Nitroxidation, nitration, and oxidation of a BODIPY fluorophore by RNOS and ROS. Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. 15: 163-76. PMID 16549377 DOI: 10.1016/j.niox.2006.01.010  0.68
2006 Clarke JL, Kastrati I, Johnston LJ, Thatcher GRJ. Photochemical reactions of thiols with organic nitrates - Oxygen atom transfer via a thionitrate Canadian Journal of Chemistry. 84: 709-719. DOI: 10.1139/V06-056  0.68
2005 Liu J, Li Q, Yang X, van Breemen RB, Bolton JL, Thatcher GR. Analysis of protein covalent modification by xenobiotics using a covert oxidatively activated tag: raloxifene proof-of-principle study. Chemical Research in Toxicology. 18: 1485-96. PMID 16167842 DOI: 10.1021/tx0501738  0.68
2005 Thatcher GR. An introduction to NO-related therapeutic agents. Current Topics in Medicinal Chemistry. 5: 597-601. PMID 16101422 DOI: 10.2174/1568026054679281  0.68
2005 Thatcher GR, Bennett BM, Reynolds JN. Nitric oxide mimetic molecules as therapeutic agents in Alzheimer's disease. Current Alzheimer Research. 2: 171-82. PMID 15974915 DOI: 10.2174/1567205053585945  0.68
2005 Liu J, Liu H, van Breemen RB, Thatcher GR, Bolton JL. Bioactivation of the selective estrogen receptor modulator acolbifene to quinone methides. Chemical Research in Toxicology. 18: 174-82. PMID 15720121 DOI: 10.1021/tx0497752  0.68
2005 Liu H, Liu J, van Breemen RB, Thatcher GR, Bolton JL. Bioactivation of the selective estrogen receptor modulator desmethylated arzoxifene to quinoids: 4'-fluoro substitution prevents quinoid formation. Chemical Research in Toxicology. 18: 162-73. PMID 15720120 DOI: 10.1021/tx049776u  0.68
2004 Thatcher GR, Bennett BM, Dringenberg HC, Reynolds JN. Novel nitrates as NO mimetics directed at Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 6: S75-84. PMID 15665418  0.68
2004 Thatcher GR, Nicolescu AC, Bennett BM, Toader V. Nitrates and NO release: contemporary aspects in biological and medicinal chemistry. Free Radical Biology & Medicine. 37: 1122-43. PMID 15451053 DOI: 10.1016/j.freeradbiomed.2004.06.013  0.68
2004 Yu L, Liu H, Li W, Zhang F, Luckie C, van Breemen RB, Thatcher GR, Bolton JL. Oxidation of raloxifene to quinoids: potential toxic pathways via a diquinone methide and o-quinones. Chemical Research in Toxicology. 17: 879-88. PMID 15257612 DOI: 10.1021/tx0342722  0.68
2004 Wang Z, Chang L, Klein WL, Thatcher GR, Venton DL. Per-6-substituted-per-6-deoxy beta-cyclodextrins inhibit the formation of beta-amyloid peptide derived soluble oligomers. Journal of Medicinal Chemistry. 47: 3329-33. PMID 15189029 DOI: 10.1021/jm034224e  0.68
2004 Bolton JL, Yu L, Thatcher GR. Quinoids formed from estrogens and antiestrogens. Methods in Enzymology. 378: 110-23. PMID 15038960 DOI: 10.1016/S0076-6879(04)78006-4  0.68
2004 Nicolescu AC, Reynolds JN, Barclay LR, Thatcher GR. Organic nitrites and NO: inhibition of lipid peroxidation and radical reactions. Chemical Research in Toxicology. 17: 185-96. PMID 14967006 DOI: 10.1021/tx034097p  0.68
2003 DiFabio J, Ji Y, Vasiliou V, Thatcher GR, Bennett BM. Role of mitochondrial aldehyde dehydrogenase in nitrate tolerance. Molecular Pharmacology. 64: 1109-16. PMID 14573760 DOI: 10.1124/mol.64.5.1109  0.68
2003 Toader V, Xu X, Nicolescu A, Yu L, Bolton JL, Thatcher GR. Nitrosation, nitration, and autoxidation of the selective estrogen receptor modulator raloxifene by nitric oxide, peroxynitrite, and reactive nitrogen/oxygen species. Chemical Research in Toxicology. 16: 1264-76. PMID 14565768 DOI: 10.1021/tx025641h  0.68
2003 Nagelkerke R, Thatcher GR, Buncel E. Alkali-metal ion catalysis and inhibition in nucleophilic displacement reactions at carbon, phosphorus and sulfur centres. IX. p-Nitrophenyl diphenyl phosphate. Organic & Biomolecular Chemistry. 1: 163-7. PMID 12929405 DOI: 10.1039/b208408b  0.68
2003 Akhter S, Green JR, Root P, Thatcher GJ, Mutus B. Peroxynitrite and NO+ donors form colored nitrite adducts with sinapinic acid: potential applications. Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. 8: 214-21. PMID 12895430 DOI: 10.1016/S1089-8603(03)00031-4  0.68
2003 Buncel E, Nagelkerke R, Thatcher GRJ. Alkali metal ion catalysis in nucleophilic displacement by ethoxide ion on p-nitrophenyl phenylphosphonate: Evidence for multiple metal ion catalysis1 Canadian Journal of Chemistry. 81: 53-63. DOI: 10.1139/v02-202  0.68
2002 Reynolds JN, Bennett BM, Boegman RJ, Jhamandas K, Ratz JD, Zavorin SI, Scutaru D, Dumitrascu A, Thatcher GR. Neuroprotection against ischemic brain injury conferred by a novel nitrate ester. Bioorganic & Medicinal Chemistry Letters. 12: 2863-6. PMID 12270164 DOI: 10.1016/S0960-894X(02)00631-5  0.68
2002 Nicolescu AC, Zavorin SI, Turro NJ, Reynolds JN, Thatcher GR. Inhibition of lipid peroxidation in synaptosomes and liposomes by nitrates and nitrites. Chemical Research in Toxicology. 15: 985-98. PMID 12119011 DOI: 10.1021/tx025529j  0.68
2001 Murray J, Macartney D, Thatcher GRJ. Catalysis of NO production by a molybdoenzyme model Organic Letters. 3: 3635-3638. PMID 11700100 DOI: 10.1021/ol0165701  0.68
2001 Artz JD, Toader V, Zavorin SI, Bennett BM, Thatcher GRJ. In vitro activation of soluble guanylyl cyclase and nitric oxide release: A comparison of NO donors and NO mimetics Biochemistry. 40: 9256-9264. PMID 11478893 DOI: 10.1021/bi002885x  0.68
2001 Lei S, Orser BA, Thatcher GR, Reynolds JN, MacDonald JF. Positive allosteric modulators of AMPA receptors reduce proton-induced receptor desensitization in rat hippocampal neurons. Journal of Neurophysiology. 85: 2030-8. PMID 11353019  0.68
2000 Smith S, Dringenberg HC, Bennett BM, Thatcher GR, Reynolds JN. A novel nitrate ester reverses the cognitive impairment caused by scopolamine in the Morris water maze. Neuroreport. 11: 3883-6. PMID 11117508  0.68
2000 Ferguson CG, Gorin BI, Thatcher GRJ. Design of novel derivatives of phosphonoformate (Foscarnet) as prodrugs and antiviral agents Journal of Organic Chemistry. 65: 1218-1221. PMID 10814076 DOI: 10.1021/jo9912909  0.68
1999 Ferguson CG, Thatcher GRJ. Catalysis and acceleration of acyl transfer by aminocyclodextrins: A biomimetic system of use in enzyme modeling and drug design Organic Letters. 1: 829-832. PMID 10823212  0.68
1999 Vizitiu D, Thatcher GRJ. Binding of phosphates to aminocyclodextrin biomimetics Journal of Organic Chemistry. 64: 6235-6238. DOI: 10.1021/jo9902392  0.68
1999 McCracken PG, Ferguson CG, Vizitiu D, Walkinshaw CS, Wang Y, Thatcher GRJ. Amino-cyclodextrins as biomimetics: Catalysis of the Kemp elimination Journal of the Chemical Society. Perkin Transactions 2. 911-912.  0.68
1998 Artz JD, Thatcher GRJ. NO release from NO donors and nitrovasodilators: Comparisons between oxyhemoglobin and potentiometric assays Chemical Research in Toxicology. 11: 1393-1397. PMID 9860479 DOI: 10.1021/tx980205+  0.68
1998 Thatcher GRJ, Weldon H. NO problem for nitroglycerin: Organic nitrate chemistry and therapy Chemical Society Reviews. 27: 331-337.  0.68
1998 Ferguson CG, Thatcher GRJ. A simple synthesis of phosphonoformamides Synlett. 1325-1326.  0.68
1997 Vizitiu D, Walkinshaw CS, Gorin BI, Thatcher GRJ. Synthesis of monofacially functionalized cyclodextrins bearing amino pendent groups Journal of Organic Chemistry. 62: 8760-8766. DOI: 10.1021/jo9711549  0.68
1997 Borrajo AMP, Gorin BI, Dostaler SM, Riopelle RJ, Thatcher GRJ. Derivatized cyclodextrins as peptidomimetics: Influence on neurite growth Bioorganic and Medicinal Chemistry Letters. 7: 1185-1190. DOI: 10.1016/S0960-894X(97)00180-7  0.68
1997 Gorin BI, Ferguson CG, Thatcher GRJ. A novel esterification procedure applied to synthesis of biologically active esters of Foscarnet Tetrahedron Letters. 38: 2791-2794. DOI: 10.1016/S0040-4039(97)00491-7  0.68
1997 McCracken PG, Bolton JL, Thatcher GRJ. Covalent Modification of Proteins and Peptides by the Quinone Methide from 2-tert-Butyl-4,6-dimethylphenol: Selectivity and Reactivity with Respect to Competitive Hydration Journal of Organic Chemistry. 62: 1820-1825.  0.68
1997 Borrajo AMP, Gal JF, Maria PC, Decouzon M, Ripley DC, Buncel E, Thatcher GRJ. Gas-Phase Cation Basicities for Sulfuryl Species from Calculation and Experiment Journal of Organic Chemistry. 62: 9203-9209.  0.68
1996 Vaino AR, Chan SS, Szarek WA, Thatcher GR. An Experimental Reexamination of the Reverse Anomeric Effect in N-Glycosylimidazoles. The Journal of Organic Chemistry. 61: 4514-4515. PMID 11667373  0.68
1996 Vizitiu D, Kriste AG, Campbell AS, Thatcher GR. Inhibition of phosphatidylinositol-specific phospholipase C: studies on synthetic substrates, inhibitors and a synthetic enzyme. Journal of Molecular Recognition : Jmr. 9: 197-209. PMID 8877813 DOI: 10.1002/(SICI)1099-1352(199603)9:2<197::AID-JMR263>3.0.CO;2-X  0.68
1996 Gorin BI, Riopelle RJ, Thatcher GRJ. Efficient perfacial derivatization of cyclodextrins at the primary face Tetrahedron Letters. 37: 4647-4650. DOI: 10.1016/0040-4039(96)00916-1  0.68
1996 Thatcher GRJ, Cameron DR. Influence of strain on hydrolysis of five-membered sulfate and phosphate esters Journal of the Chemical Society. Perkin Transactions 2. 5: 767-769.  0.68
1996 Cameron DR, Thatcher GRJ. Mechanisms of reaction of sulfate esters: A molecular orbital study of associative sulfuryl group transfer, intramolecular migration, and pseudorotation Journal of Organic Chemistry. 61: 5986-5997.  0.68
1996 Kriste AG, Vizitiu D, Thatcher GRJ. A metallomicelle enzyme model for phospholipase C catalysis and inhibition Chemical Communications. 913-914.  0.68
1996 Williams VE, Lemieux RP, Thatcher GRJ. Substituent effects on the stability of arene-arene complexes: An AM1 study of the conformational equilibria of cis-1,3-diphenylcyclohexanes Journal of Organic Chemistry. 61: 1927-1933.  0.68
1996 Artz JD, Yang K, Lock J, Sanchez C, Bennett BM, Thatcher GRJ. Reactivity of thionitrate esters: Putative intermediates in nitrovasodilator activity Chemical Communications. 927-928.  0.68
1996 Yang K, Artz JD, Lock J, Sanchez C, Bennett BM, Fraser AB, Thatcher GRJ. Synthesis of novel organic nitrate esters: Guanylate cyclase activation and tissue relaxation Journal of the Chemical Society - Perkin Transactions 1. 1073-1075.  0.68
1995 Chan SSC, Szarek WA, Thatcher GRJ. The reverse anomeric effect in N-pyranosylimidazolides: A molecular orbital study Journal of the Chemical Society, Perkin Transactions 2. 45-60.  0.68
1995 Pregel MJ, Dunn EJ, Nagelkerke R, Thatcher GRJ, Buncel E. Alkali-metal ion catalysis and inhibition in nucleophilic displacement reactions of phosphorus-, sulfur- and carbon-based esters Chemical Society Reviews. 24: 449-455.  0.68
1994 Thatcher GRJ, Krol ES, Cameron DR. Stereoelectronic effects in pentacoordinate intermediates and acceleration of nucleophilic substitution at phosphorus Journal of the Chemical Society, Perkin Transactions 2. 683-690.  0.68
1994 Palmer DRJ, Buncel E, Thatcher GRJ. Re-evaluation of cyclodextrin as a model of chymotrypsin: Acceleration and inhibition of tertiary anilide hydrolysis Journal of Organic Chemistry. 59: 5286-5291.  0.68
1993 Krol ES, Thatcher GRJ. Hydrolysis of phosphonoformate triesters: Rate acceleration of a millionfold in nucleophilic substitution at phosphorus Journal of the Chemical Society, Perkin Transactions 2. 793-794.  0.68
1993 Thatcher GRJ, Campbell AS. Phosphonates as mimics of phosphate biomolecules: Ab initio calculations on tetrahedral ground states and pentacoordinate intermediates for phosphoryl transfer Journal of Organic Chemistry. 58: 2272-2281.  0.68
1992 Thatcher GRJ, Cameron DR, Nagelkerke R, Schmitke J. Selective hydrogen bonding as a mechanism for differentiation of sulfate and phosphate at biomolecular receptor sites Journal of the Chemical Society, Chemical Communications. 386-388. DOI: 10.1039/C39920000386  0.68
1992 Stewart Campbell A, Thatcher GRJ. Tetravanadate is an inhibitor of phosphatidyl inositol-specific phospholipase C Bioorganic and Medicinal Chemistry Letters. 2: 655-658. DOI: 10.1016/S0960-894X(00)80384-4  0.68
1991 Krol ES, Davis JM, Thatcher GRJ. Hydrolysis of phosphonoformate esters: Product distribution and reactivity patterns Journal of the Chemical Society, Chemical Communications. 118-119. DOI: 10.1039/C39910000118  0.68
1991 Stewart Campbell A, Thatcher GRJ. Synthesis of an analogue of D,L-MYO-inositol-1,2-cyclic phosphate: inhibition of phosphatidylinositol-specific phospholipase C Tetrahedron Letters. 32: 2207-2210. DOI: 10.1016/S0040-4039(00)79682-1  0.68
1991 Davis JM, Cameron DR, Kubanek JM, Mizuyabu L, Thatcher GRJ. Acceleration of sulfate ester hydrolysis in hydrophobic environments Tetrahedron Letters. 32: 2205-2206. DOI: 10.1016/S0040-4039(00)79681-X  0.68
1988 Lowe G, Thatcher GRJ, Turner JCG, Waller A, Watkin DJ. Stereoelectronic effects in sulfate diesters and sulfuric acid Journal of the American Chemical Society. 110: 8512-8520.  0.68
1987 Blackburn GM, Taylor GE, Thatcher GR, Prescott M, McLennan AG. Synthesis and resistance to enzymic hydrolysis of stereochemically-defined phosphonate and thiophosphate analogues of P1,P4-bis(5'-adenosyl) tetraphosphate. Nucleic Acids Research. 15: 6991-7004. PMID 2821489  0.68
1987 Blackburn GM, Thatcher GRJ, Hosseini MW, Lehn JM. Evidence for a protophosphatase catalysed cleavage of adenosine triphosphate by a dissociative-type mechanism within a receptor-substrate complex Tetrahedron Letters. 28: 2779-2782. DOI: 10.1016/S0040-4039(00)96208-7  0.68
1987 Kluger R, Thatcher GRJ, Stallings WC. Synthesis, structure, and hydrolysis of esters of strained and unstrained N-phosphonylureas Canadian Journal of Chemistry. 65: 1838-1844.  0.68
1986 Kluger R, Thatcher GRJ. Exocyclic cleavage in the alkaline hydrolysis of methyl ethylene phosphate: Pseudorotation of a pentavalent intermediate or reaction via a hexavalent intermediate? Journal of Organic Chemistry. 51: 207-212.  0.68
1986 Thatcher GRJ, Poirier R, Kluger R. Enzymic carboxyl transfer from N-carboxybiotin. A molecular orbital evaluation of conformational effects in promoting reactivity Journal of the American Chemical Society®. 108: 2699-2704.  0.68
1985 Kluger R, Thatcher GRJ. Exocyclic cleavage in the alkaline hydrolysis of methyl ethylene phosphate. Evidence against the significance of stereoelectronic acceleration in reactions of cyclic phosphates Journal of the American Chemical Society. 107: 6006-6011.  0.68
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