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Gregory Thatcher - Publications

Affiliations: 
University of Illinois at Chicago, Chicago, IL, United States 
Area:
Biochemistry
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49/269 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 O'Regan R, Hurley R, Sachdev J, Bleeker J, Tonetti D, Thatcher G, Venuti R, Dudek A. Abstract P5-11-06: Phase 1 study of TTC-352 in patients with metastatic breast cancer progressing on endocrine therapy Cancer Research. 80. DOI: 10.1158/1538-7445.Sabcs19-P5-11-06  0.323
2019 ORegan RM, Hurley R, Sachdev JC, Bleeker J, Tonetti D, Thatcher G, Venuti R, Dudek AZ. Abstract CT051: Phase I study of TTC-352 in patients with estrogen receptor-positive metastatic breast cancer Cancer Research. 79. DOI: 10.1158/1538-7445.Am2019-Ct051  0.31
2019 Xiong R, Li Y, Zhao J, Tonetti D, Thatcher G. Abstract 3830: Novel bromodomains and extra-terminal motif (BET) inhibitors developed against estrogen receptor positive, fulvestrant- and CDK4/6-resistant breast cancer models Cancer Research. 79: 3830-3830. DOI: 10.1158/1538-7445.Am2019-3830  0.404
2018 Gaisina IN, Lee SH, Kaidery NA, Ben Aissa M, Ahuja M, Smirnova NN, Wakade S, Gaisin A, Bourassa MW, Ratan RR, Nikulin SV, Poloznikov AA, Thomas B, Thatcher GRJ, Gazaryan IG. Activation of Nrf2 and Hypoxic Adaptive Response Contribute to Neuroprotection Elicited by Phenylhydroxamic Acid Selective HDAC6 Inhibitors. Acs Chemical Neuroscience. PMID 29338172 DOI: 10.1021/Acschemneuro.7B00435  0.302
2017 Petukhov PA, Abdelkarim H, Neelarapu R, Madriaga A, Kastrati I, Wang YT, Vaidya AS, Taha TY, Thatcher GRJ, Frasor J. Design, Synthesis, Molecular Modeling, and Biological Evaluation of Novel Amine-based Histone Deacetylase Inhibitors. Chemmedchem. PMID 29080240 DOI: 10.1002/Cmdc.201700449  0.686
2017 Kastrati I, Siklos MI, Brovkovych SD, Thatcher GR, Frasor J. A Novel Strategy to Co-target Estrogen Receptor and Nuclear Factor κB Pathways with Hybrid Drugs for Breast Cancer Therapy. Hormones & Cancer. PMID 28396978 DOI: 10.1007/S12672-017-0294-5  0.73
2017 Kastrati I, Delgado-Rivera L, Georgieva G, Thatcher GR, Frasor J. Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells. Journal of Visualized Experiments : Jove. PMID 28190074 DOI: 10.3791/54798  0.732
2016 Pierce EN, Piyankarage SC, Dunlap TL, Litosh VA, Siklos MI, Wang YT, Thatcher GR. Prodrugs Bioactivated to Quinones Target NF-κB and Multiple Protein Networks: Identification of the Quinonome. Chemical Research in Toxicology. PMID 27258437 DOI: 10.1021/Acs.Chemrestox.6B00115  0.306
2016 Kastrati I, Siklos MI, Calderon-Gierszal EL, El-Shennawy L, Georgieva G, Thayer EN, Thatcher GR, Frasor J. Dimethyl Fumarate Inhibits the Nuclear Factor κB Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein. The Journal of Biological Chemistry. 291: 3639-47. PMID 26683377 DOI: 10.1074/Jbc.M115.679704  0.742
2016 Xiong R, Zhao J, Gutgesell L, Tonetti D, Thatcher G. Abstract 3902: Novel selective estrogen receptor downregulators developed using endocrine-independent breast cancer cell lines Cancer Research. 76: 3902-3902. DOI: 10.1158/1538-7445.Am2016-3902  0.391
2015 Kastrati I, Litosh VA, Zhao S, Alvarez M, Thatcher GR, Frasor J. A novel aspirin prodrug inhibits NFκB activity and breast cancer stem cell properties. Bmc Cancer. 15: 845. PMID 26530254 DOI: 10.1186/S12885-015-1868-7  0.733
2015 Fà M, Zhang H, Staniszewski A, Saeed F, Shen LW, Schiefer IT, Siklos MI, Tapadar S, Litosh VA, Libien J, Petukhov PA, Teich AF, Thatcher GR, Arancio O. Novel Selective Calpain 1 Inhibitors as Potential Therapeutics in Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 26484927 DOI: 10.3233/Jad-150618  0.707
2015 Kastrati I, Siklos M, Litosh V, Thatcher G, Frasor J. Abstract 4497: Design and synthesis of hybrid drugs to target inflammatory pathways in breast cancer Cancer Research. 75: 4497-4497. DOI: 10.1158/1538-7445.Am2015-4497  0.75
2013 Schiefer IT, Tapadar S, Litosh V, Siklos M, Scism R, Wijewickrama GT, Chandrasena EP, Sinha V, Tavassoli E, Brunsteiner M, Fa' M, Arancio O, Petukhov P, Thatcher GR. Design, synthesis, and optimization of novel epoxide incorporating peptidomimetics as selective calpain inhibitors. Journal of Medicinal Chemistry. 56: 6054-68. PMID 23834438 DOI: 10.1021/Jm4006719  0.715
2013 Siklos MI, Gandhi RP, Xiong R, Schiefer IT, Litosh V, VandeVrede L, Thatcher GR. Discovery of neuroprotective soluble guanylate cyclase modulators (GCMs) aciting via NO/GC/cGMP/CREB pathway Bmc Pharmacology and Toxicology. 14. DOI: 10.1186/2050-6511-14-S1-P65  0.723
2012 Dunlap T, Piyankarage SC, Wijewickrama GT, Abdul-Hay S, Vanni M, Litosh V, Luo J, Thatcher GR. Quinone-induced activation of Keap1/Nrf2 signaling by aspirin prodrugs masquerading as nitric oxide. Chemical Research in Toxicology. 25: 2725-36. PMID 23035985 DOI: 10.1021/Tx3003609  0.747
2012 Schiefer IT, VandeVrede L, Fa' M, Arancio O, Thatcher GR. Furoxans (1,2,5-oxadiazole-N-oxides) as novel NO mimetic neuroprotective and procognitive agents. Journal of Medicinal Chemistry. 55: 3076-87. PMID 22429006 DOI: 10.1021/Jm201504S  0.725
2012 Hemachandra LPMP, Choi J, Bolotn J, Thatcher G. Abstract LB-64: Selective estrogen receptor modulators (SERMs) act as breast cancer chemopreventive agents by attenuating oxidative estrogen metabolism Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Lb-64  0.407
2011 Kastrati I, Edirisinghe PD, Hemachandra LP, Chandrasena ER, Choi J, Wang YT, Bolton JL, Thatcher GR. Raloxifene and desmethylarzoxifene block estrogen-induced malignant transformation of human breast epithelial cells. Plos One. 6: e27876. PMID 22140478 DOI: 10.1371/Journal.Pone.0027876  0.703
2011 Abdul-Hay S, Schiefer IT, Chandrasena RE, Li M, Abdelhamid R, Wang YT, Tavassoli E, Michalsen B, Asghodom RT, Luo J, Thatcher GR. NO-SSRIs: Nitric Oxide Chimera Drugs Incorporating a Selective Serotonin Reuptake Inhibitor. Acs Medicinal Chemistry Letters. 2: 656-661. PMID 21927645 DOI: 10.1021/Ml2000033  0.769
2011 Abdelhamid R, Luo J, Vandevrede L, Kundu I, Michalsen B, Litosh VA, Schiefer IT, Gherezghiher T, Yao P, Qin Z, Thatcher GR. Benzothiophene Selective Estrogen Receptor Modulators Provide Neuroprotection by a novel GPR30-dependent Mechanism. Acs Chemical Neuroscience. 2: 256-268. PMID 21731800 DOI: 10.1021/Cn100106A  0.743
2011 Schiefer IT, Abdul-Hay S, Wang H, Vanni M, Qin Z, Thatcher GR. Inhibition of amyloidogenesis by nonsteroidal anti-inflammatory drugs and their hybrid nitrates. Journal of Medicinal Chemistry. 54: 2293-306. PMID 21405086 DOI: 10.1021/Jm101450P  0.783
2010 Kastrati I, Edirisinghe PD, Wijewickrama GT, Thatcher GR. Estrogen-induced apoptosis of breast epithelial cells is blocked by NO/cGMP and mediated by extranuclear estrogen receptors. Endocrinology. 151: 5602-16. PMID 20943808 DOI: 10.1210/En.2010-0378  0.703
2010 Peng KW, Chang M, Wang YT, Wang Z, Qin Z, Bolton JL, Thatcher GR. Unexpected hormonal activity of a catechol equine estrogen metabolite reveals reversible glutathione conjugation. Chemical Research in Toxicology. 23: 1374-83. PMID 20540524 DOI: 10.1021/Tx100129H  0.312
2010 Sinha V, Wijewickrama GT, Chandrasena RE, Xu H, Edirisinghe PD, Schiefer IT, Thatcher GR. Proteomic and mass spectroscopic quantitation of protein S-nitrosation differentiates NO-donors. Acs Chemical Biology. 5: 667-80. PMID 20524644 DOI: 10.1021/Cb100054M  0.685
2010 Anand S, Schiefer IT, Thatcher GRJ. Nitric oxide donor and mimetic molecules in cancer chemotherapy and chemoprevention Forum On Immunopathological Diseases and Therapeutics. 1: 251-279. DOI: 10.1615/Forumimmundisther.V1.I4.20  0.698
2009 Abdul-Hay SO, Edirisinghe P, Thatcher GR. Selective modulation of amyloid-beta peptide degradation by flurbiprofen, fenofibrate, and related compounds regulates Abeta levels. Journal of Neurochemistry. 111: 683-95. PMID 19702658 DOI: 10.1111/j.1471-4159.2009.06355.x  0.702
2009 Abdul-Hay SO, Luo J, Ashghodom RT, Thatcher GR. NO-flurbiprofen reduces amyloid-beta, is neuroprotective in cell culture, and enhances cognition in response to cholinergic blockade. Journal of Neurochemistry. 111: 766-76. PMID 19702655 DOI: 10.1111/j.1471-4159.2009.06353.x  0.745
2009 Chirapu SR, Pachaiyappan B, Nural HF, Cheng X, Yuan H, Lankin DC, Abdul-Hay SO, Thatcher GR, Shen Y, Kozikowski AP, Petukhov PA. Molecular modeling, synthesis, and activity studies of novel biaryl and fused-ring BACE1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 264-74. PMID 19013792 DOI: 10.1016/J.Bmcl.2008.10.096  0.725
2009 Qin Z, Kastrati I, Ashgodom RT, Lantvit DD, Overk CR, Choi Y, van Breemen RB, Bolton JL, Thatcher GR. Structural modulation of oxidative metabolism in design of improved benzothiophene selective estrogen receptor modulators. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 161-9. PMID 18936111 DOI: 10.1124/Dmd.108.023408  0.692
2009 Molloy M, Thatcher G, Bolton J, Tonetti D. 2-(4-Hydroxyphenyl)-Benzo[b]thiophen-6-ol, an Estrogen-Like Compound, Induces Apoptosis in T47D/PKCα Breast Cancer Cells. Cancer Research. 69: 5140-5140. DOI: 10.1158/0008-5472.Sabcs-09-5140  0.398
2008 Hagos GK, Abdul-Hay SO, Sohn J, Edirisinghe PD, Chandrasena RE, Wang Z, Li Q, Thatcher GR. Anti-inflammatory, antiproliferative, and cytoprotective activity of NO chimera nitrates of use in cancer chemoprevention. Molecular Pharmacology. 74: 1381-91. PMID 18676677 DOI: 10.1124/Mol.108.046664  0.772
2008 Chang M, Overk CR, Kastrati I, Peng KW, Yao P, Qin ZH, Petukhov P, Bolton JL, Thatcher GR. Estrogenic activity of the equine estrogen metabolite, 4-methoxyequilenin. Advances in Experimental Medicine and Biology. 617: 601-7. PMID 18497087 DOI: 10.1007/978-0-387-69080-3_62  0.695
2008 Dunlap T, Abdul-Hay SO, Chandrasena RE, Hagos GK, Sinha V, Wang Z, Wang H, Thatcher GR. Nitrates and NO-NSAIDs in cancer chemoprevention and therapy: in vitro evidence querying the NO donor functionality. Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. 19: 115-24. PMID 18485921 DOI: 10.1016/J.Niox.2008.04.013  0.776
2007 Dunlap T, Chandrasena RE, Wang Z, Sinha V, Wang Z, Thatcher GR. Quinone formation as a chemoprevention strategy for hybrid drugs: balancing cytotoxicity and cytoprotection. Chemical Research in Toxicology. 20: 1903-12. PMID 17975886 DOI: 10.1021/Tx7002257  0.344
2007 Yu B, Dietz BM, Dunlap T, Kastrati I, Lantvit DD, Overk CR, Yao P, Qin Z, Bolton JL, Thatcher GR. Structural modulation of reactivity/activity in design of improved benzothiophene selective estrogen receptor modulators: induction of chemopreventive mechanisms. Molecular Cancer Therapeutics. 6: 2418-28. PMID 17876041 DOI: 10.1158/1535-7163.Mct-07-0268  0.737
2007 Hagos GK, Carroll RE, Kouznetsova T, Li Q, Toader V, Fernandez PA, Swanson SM, Thatcher GR. Colon cancer chemoprevention by a novel NO chimera that shows anti-inflammatory and antiproliferative activity in vitro and in vivo. Molecular Cancer Therapeutics. 6: 2230-9. PMID 17699720 DOI: 10.1158/1535-7163.Mct-07-0069  0.799
2007 Overk CR, Peng KW, Asghodom RT, Kastrati I, Lantvit DD, Qin Z, Frasor J, Bolton JL, Thatcher GR. Structure-activity relationships for a family of benzothiophene selective estrogen receptor modulators including raloxifene and arzoxifene. Chemmedchem. 2: 1520-6. PMID 17654759 DOI: 10.1002/Cmdc.200700104  0.711
2007 Chang M, Peng KW, Kastrati I, Overk CR, Qin ZH, Yao P, Bolton JL, Thatcher GR. Activation of estrogen receptor-mediated gene transcription by the equine estrogen metabolite, 4-methoxyequilenin, in human breast cancer cells. Endocrinology. 148: 4793-802. PMID 17584965 DOI: 10.1210/En.2006-1568  0.703
2007 Qin Z, Kastrati I, Chandrasena RE, Liu H, Yao P, Petukhov PA, Bolton JL, Thatcher GR. Benzothiophene selective estrogen receptor modulators with modulated oxidative activity and receptor affinity. Journal of Medicinal Chemistry. 50: 2682-92. PMID 17489582 DOI: 10.1021/Jm070079J  0.708
2006 Clarke JL, Kastrati I, Johnston LJ, Thatcher GRJ. Photochemical reactions of thiols with organic nitrates - Oxygen atom transfer via a thionitrate Canadian Journal of Chemistry. 84: 709-719. DOI: 10.1139/V06-056  0.655
2005 Liu J, Liu H, van Breemen RB, Thatcher GR, Bolton JL. Bioactivation of the selective estrogen receptor modulator acolbifene to quinone methides. Chemical Research in Toxicology. 18: 174-82. PMID 15720121 DOI: 10.1021/Tx0497752  0.307
2005 Liu H, Liu J, van Breemen RB, Thatcher GR, Bolton JL. Bioactivation of the selective estrogen receptor modulator desmethylated arzoxifene to quinoids: 4'-fluoro substitution prevents quinoid formation. Chemical Research in Toxicology. 18: 162-73. PMID 15720120 DOI: 10.1021/Tx049776U  0.336
1987 Kluger R, Thatcher GRJ, Stallings WC. Synthesis, structure, and hydrolysis of esters of strained and unstrained N-phosphonylureas Canadian Journal of Chemistry. 65: 1838-1844.  0.454
1986 Thatcher GRJ, Poirier R, Kluger R. Enzymic carboxyl transfer from N-carboxybiotin. A molecular orbital evaluation of conformational effects in promoting reactivity Journal of the American Chemical Society®. 108: 2699-2704. DOI: 10.1021/Ja00270A031  0.452
1986 THATCHER GRJ, POIRIER R, KLUGER R. ChemInform Abstract: Enzymic Carboxyl Transfer from N-Carboxybiotin. A MO Evaluation of Conformational Effects in Promoting Reactivity. Chemischer Informationsdienst. 17. DOI: 10.1002/Chin.198637071  0.451
1986 KLUGER R, THATCHER GRJ. ChemInform Abstract: Exocyclic Cleavage in the Alkaline Hydrolysis of Methyl Ethylene Phosphate. Chemischer Informationsdienst. 17. DOI: 10.1002/chin.198605239  0.425
1986 Kluger R, Thatcher GRJ. Exocyclic cleavage in the alkaline hydrolysis of methyl ethylene phosphate: Pseudorotation of a pentavalent intermediate or reaction via a hexavalent intermediate? Journal of Organic Chemistry. 51: 207-212.  0.454
1985 Kluger R, Thatcher GRJ. Exocyclic cleavage in the alkaline hydrolysis of methyl ethylene phosphate. Evidence against the significance of stereoelectronic acceleration in reactions of cyclic phosphates Journal of the American Chemical Society. 107: 6006-6011.  0.453
Low-probability matches (unlikely to be authored by this person)
2020 Andreano KJ, Wardell SE, Baker JG, Desautels TK, Baldi R, Chao CA, Heetderks KA, Bae Y, Xiong R, Tonetti DA, Gutgesell LM, Zhao J, Sorrentino JA, Thompson DA, Bisi JE, ... ... Thatcher GRJ, et al. G1T48, an oral selective estrogen receptor degrader, and the CDK4/6 inhibitor lerociclib inhibit tumor growth in animal models of endocrine-resistant breast cancer. Breast Cancer Research and Treatment. PMID 32130619 DOI: 10.1007/S10549-020-05575-9  0.3
2014 Patel HK, Siklos MI, Abdelkarim H, Mendonca EL, Vaidya A, Petukhov PA, Thatcher GR. A chimeric SERM-histone deacetylase inhibitor approach to breast cancer therapy. Chemmedchem. 9: 602-13. PMID 23956109 DOI: 10.1002/Cmdc.201300270  0.298
2021 Gaisina IN, Hushpulian DM, Gaisin AM, Kazakov EH, Kaidery NA, Ahuja M, Poloznikov AA, Gazaryan IG, Thatcher GRJ, Thomas B. Identification of a potent Nrf2 displacement activator among aspirin-containing prodrugs. Neurochemistry International. 105148. PMID 34329734 DOI: 10.1016/j.neuint.2021.105148  0.297
2005 Thatcher GR. An introduction to NO-related therapeutic agents. Current Topics in Medicinal Chemistry. 5: 597-601. PMID 16101422 DOI: 10.2174/1568026054679281  0.296
2009 Peng KW, Wang H, Qin Z, Wijewickrama GT, Lu M, Wang Z, Bolton JL, Thatcher GR. Selective estrogen receptor modulator delivery of quinone warheads to DNA triggering apoptosis in breast cancer cells. Acs Chemical Biology. 4: 1039-49. PMID 19839584 DOI: 10.1021/Cb9001848  0.296
2019 Xiong R, Li Y, Zhao J, Huang F, Shen Z, Lu Y, Gutgesell L, Tonetti D, Thatcher G. Basic selective estrogen receptor degraders (B-SERDs) in combination with novel BET inhibitors in ER+ breast cancer Annals of Oncology. 30: v189. DOI: 10.1093/Annonc/Mdz244.064  0.289
2023 Nair RS, Kumar S, Das S, Singh SK, Srivastava P, Sondarva G, Rao A, Sinha SC, Xiong R, Bloem L, Hoskins K, Thatcher GRJ, Rana B, Rana A. TrkA expression directs the anti-neoplastic activity of MLK3 inhibitors in triple-negative breast cancer. Oncogene. PMID 36813855 DOI: 10.1038/s41388-023-02633-6  0.288
2007 Liu H, Qin Z, Thatcher GR, Bolton JL. Uterine peroxidase-catalyzed formation of diquinone methides from the selective estrogen receptor modulators raloxifene and desmethylated arzoxifene. Chemical Research in Toxicology. 20: 1676-84. PMID 17630709 DOI: 10.1021/Tx7001367  0.286
2012 Hemachandra LP, Madhubhani P, Chandrasena R, Esala P, Chen SN, Main M, Lankin DC, Scism RA, Dietz BM, Pauli GF, Thatcher GR, Bolton JL. Hops (Humulus lupulus) inhibits oxidative estrogen metabolism and estrogen-induced malignant transformation in human mammary epithelial cells (MCF-10A). Cancer Prevention Research (Philadelphia, Pa.). 5: 73-81. PMID 21997247 DOI: 10.1158/1940-6207.Capr-11-0348  0.284
2018 Silvestri I, Lyu H, Fata F, Boumis G, Miele AE, Ardini M, Ippoliti R, Bellelli A, Jadhav A, Lea WA, Simeonov A, Chen Q, Arner ESJ, Thatcher GR, Petukhov PA, et al. Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as "Doorstop" for NADPH Entry. Acs Chemical Biology. PMID 29800515 DOI: 10.1021/Acschembio.8B00349  0.284
2014 Hemachandra LP, Patel H, Chandrasena RE, Choi J, Piyankarage SC, Wang S, Wang Y, Thayer EN, Scism RA, Michalsen BT, Xiong R, Siklos MI, Bolton JL, Thatcher GR. SERMs attenuate estrogen-induced malignant transformation of human mammary epithelial cells by upregulating detoxification of oxidative metabolites. Cancer Prevention Research (Philadelphia, Pa.). 7: 505-15. PMID 24598415 DOI: 10.1158/1940-6207.Capr-13-0296  0.283
2006 Liu H, Bolton JL, Thatcher GR. Chemical modification modulates estrogenic activity, oxidative reactivity, and metabolic stability in 4'F-DMA, a new benzothiophene selective estrogen receptor modulator. Chemical Research in Toxicology. 19: 779-87. PMID 16780356 DOI: 10.1021/Tx050326R  0.278
2015 Xiong R, Patel HK, Gutgesell LM, Zhao J, Delgado-Rivera L, Pham TN, Zhao H, Carlson KE, Martin TA, Katzenellenbogen JA, Moore TW, Tonetti D, Thatcher GR. Selective human Estrogen Receptor Partial Agonists (ShERPAs) for Tamoxifen-Resistant Breast Cancer. Journal of Medicinal Chemistry. PMID 26681208 DOI: 10.1021/Acs.Jmedchem.5B01276  0.278
2013 VandeVrede L, Abdelhamid R, Qin Z, Choi J, Piyankarage S, Luo J, Larson J, Bennett BM, Thatcher GR. An NO donor approach to neuroprotective and procognitive estrogen therapy overcomes loss of NO synthase function and potentially thrombotic risk. Plos One. 8: e70740. PMID 23976955 DOI: 10.1371/Journal.Pone.0070740  0.277
2020 Abderrahman B, Maximov PY, Curpan RF, Fanning SW, Hanspal JS, Fan P, Foulds CE, Chen Y, Malovannaya A, Jain A, Xiong R, Greene GL, Tonetti DA, Thatcher GRJ, Jordan VC. Rapid Induction of the Unfolded Protein Response and Apoptosis by Estrogen Mimic TTC-352 for the Treatment of Endocrine-Resistant Breast Cancer. Molecular Cancer Therapeutics. PMID 33177154 DOI: 10.1158/1535-7163.MCT-20-0563  0.276
2020 Kumar S, Singh SK, Viswakarma N, Sondarva G, Nair RS, Sethupathi P, Dorman M, Sinha SC, Hoskins K, Thatcher G, Rana B, Rana A. Rationalized inhibition of mixed lineage kinase 3 and CD70 enhances life span and antitumor efficacy of CD8 T cells. Journal For Immunotherapy of Cancer. 8. PMID 32759234 DOI: 10.1136/Jitc-2019-000494  0.276
2008 Bolton JL, Thatcher GR. Potential mechanisms of estrogen quinone carcinogenesis. Chemical Research in Toxicology. 21: 93-101. PMID 18052105 DOI: 10.1021/Tx700191P  0.274
2020 Abderrahman B, Maximov PY, Curpan RF, Hanspal JS, Fan P, Xiong R, Tonetti DA, Thatcher GRJ, Jordan VC. Pharmacology and Molecular Mechanisms of Clinically-Relevant Estrogen Estetrol and Estrogen Mimic BMI-135 for Endocrine-Resistant Breast Cancer Treatment. Molecular Pharmacology. PMID 32788222 DOI: 10.1124/Molpharm.120.000054  0.269
2022 Principe DR, Xiong R, Li Y, Pham TND, Kamath SD, Dubrovskyi O, Ratia K, Huang F, Zhao J, Shen Z, Thummuri D, Daohong Z, Underwood PW, Trevino J, Munshi HG, ... Thatcher GRJ, et al. XP-524 is a dual-BET/EP300 inhibitor that represses oncogenic KRAS and potentiates immune checkpoint inhibition in pancreatic cancer. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35064087 DOI: 10.1073/pnas.2116764119  0.269
2014 Nicolescu AC, Thatcher GRJ. Differential activation of soluble guanylate cyclase by a series of aryl disulfanyl dinitrate esters Medchemcomm. 5: 51-56. DOI: 10.1039/c3md00261f  0.263
2005 Thatcher GR, Bennett BM, Reynolds JN. Nitric oxide mimetic molecules as therapeutic agents in Alzheimer's disease. Current Alzheimer Research. 2: 171-82. PMID 15974915 DOI: 10.2174/1567205053585945  0.263
2015 Luo J, Lee SH, VandeVrede L, Qin Z, Piyankarage S, Tavassoli E, Asghodom RT, Aissa MB, Fà M, Arancio O, Yue L, Pepperberg DR, Thatcher GR. Re-engineering a neuroprotective, clinical drug as a procognitive agent with high in vivo potency and with GABAA potentiating activity for use in dementia. Bmc Neuroscience. 16: 67. PMID 26480871 DOI: 10.1186/S12868-015-0208-9  0.26
2017 Xiong R, Zhao J, Gutgesell LM, Wang YT, Lee S, Karumudi B, Zhao H, Lu Y, Tonetti DA, Thatcher GR. Novel Selective Estrogen Receptor Downregulators (SERDs) Developed Against Treatment-Resistant Breast Cancer. Journal of Medicinal Chemistry. PMID 28117994 DOI: 10.1021/Acs.Jmedchem.6B01355  0.259
2020 Cooper L, Schafer A, Li Y, Cheng H, Medegan Fagla B, Shen Z, Nowar R, Dye K, Anantpadma M, Davey RA, Thatcher GR, Rong L, Xiong R. Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors. Journal of Medicinal Chemistry. PMID 32886512 DOI: 10.1021/Acs.Jmedchem.0C01001  0.258
2016 Luo J, Lee SH, VandeVrede L, Qin Z, Ben Aissa M, Larson J, Teich AF, Arancio O, D'Souza Y, Elharram A, Koster K, Tai LM, LaDu MJ, Bennett BM, Thatcher GR. A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer's disease. Molecular Neurodegeneration. 11: 35. PMID 27129593 DOI: 10.1186/S13024-016-0103-6  0.257
2004 Thatcher GR, Nicolescu AC, Bennett BM, Toader V. Nitrates and NO release: contemporary aspects in biological and medicinal chemistry. Free Radical Biology & Medicine. 37: 1122-43. PMID 15451053 DOI: 10.1016/j.freeradbiomed.2004.06.013  0.255
2007 Thatcher G. A10. Nitrates in chemoprevention: Correlating activity with structure and NO release Nitric Oxide. 17: 11. DOI: 10.1016/J.Niox.2007.09.015  0.25
2022 Poloznikov AA, Nikulin SV, Hushpulian DM, Khristichenko AY, Osipyants AI, Asachenko AF, Shurupova OV, Savin SS, Lee SH, Gaisina IN, Thatcher GRJ, Narciso A, Chang EP, Kazakov SV, Krucher N, et al. Structure-Activity Relationships and Transcriptomic Analysis of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors. Antioxidants (Basel, Switzerland). 11. PMID 35204103 DOI: 10.3390/antiox11020220  0.25
2005 Liu J, Li Q, Yang X, van Breemen RB, Bolton JL, Thatcher GR. Analysis of protein covalent modification by xenobiotics using a covert oxidatively activated tag: raloxifene proof-of-principle study. Chemical Research in Toxicology. 18: 1485-96. PMID 16167842 DOI: 10.1021/Tx0501738  0.25
2012 Michalsen BT, Gherezghiher TB, Choi J, Chandrasena RE, Qin Z, Thatcher GR, Bolton JL. Selective estrogen receptor modulator (SERM) lasofoxifene forms reactive quinones similar to estradiol. Chemical Research in Toxicology. 25: 1472-83. PMID 22642258 DOI: 10.1021/Tx300142H  0.25
2021 Shen Z, Ratia K, Cooper L, Kong D, Lee H, Kwon Y, Li Y, Alqarni S, Huang F, Dubrovskyi O, Rong L, Thatcher GR, Xiong R. Potent, Novel SARS-CoV-2 PLpro Inhibitors Block Viral Replication in Monkey and Human Cell Cultures. Biorxiv : the Preprint Server For Biology. PMID 33594371 DOI: 10.1101/2021.02.13.431008  0.249
2004 Bolton JL, Yu L, Thatcher GR. Quinoids formed from estrogens and antiestrogens. Methods in Enzymology. 378: 110-23. PMID 15038960 DOI: 10.1016/S0076-6879(04)78006-4  0.249
2018 Schafer A, Cheng H, Xiong R, Soloveva V, Retterer C, Mo F, Bavari S, Thatcher G, Rong L. Repurposing potential of 1st generation H-specific antihistamines as anti-filovirus therapeutics. Antiviral Research. PMID 29981374 DOI: 10.1016/J.Antiviral.2018.07.003  0.248
2019 Silvestri I, Lyu H, Fata F, Banta PR, Mattei B, Ippoliti R, Bellelli A, Pitari G, Ardini M, Petukhova V, Thatcher GRJ, Petukhov PA, Williams DL, Angelucci F. Ectopic suicide inhibition of thioredoxin glutathione reductase. Free Radical Biology & Medicine. PMID 31870799 DOI: 10.2210/Pdb6Rto/Pdb  0.248
2003 Toader V, Xu X, Nicolescu A, Yu L, Bolton JL, Thatcher GR. Nitrosation, nitration, and autoxidation of the selective estrogen receptor modulator raloxifene by nitric oxide, peroxynitrite, and reactive nitrogen/oxygen species. Chemical Research in Toxicology. 16: 1264-76. PMID 14565768 DOI: 10.1021/Tx025641H  0.247
2019 Lu Y, Gutgesell L, Xiong R, Zhao J, Li Y, Rosales C, Hollas M, Shen Z, Gordon-Blake J, Dye K, Wang YT, Lee S, Chen H, He D, Dubrovyskyii O, ... ... Thatcher GR, et al. Design and Synthesis of Basic Selective Estrogen Receptor Degraders (B-SERDs) for Endocrine Therapy Resistant Breast Cancer. Journal of Medicinal Chemistry. PMID 31746603 DOI: 10.1021/Acs.Jmedchem.9B01580  0.245
2004 Yu L, Liu H, Li W, Zhang F, Luckie C, van Breemen RB, Thatcher GR, Bolton JL. Oxidation of raloxifene to quinoids: potential toxic pathways via a diquinone methide and o-quinones. Chemical Research in Toxicology. 17: 879-88. PMID 15257612 DOI: 10.1021/Tx0342722  0.243
2008 Chandrasena RE, Edirisinghe PD, Bolton JL, Thatcher GR. Problematic detoxification of estrogen quinones by NAD(P)H-dependent quinone oxidoreductase and glutathione-S-transferase. Chemical Research in Toxicology. 21: 1324-9. PMID 18588320 DOI: 10.1021/Tx8000797  0.243
2012 Luo J, VandeVrede L, Qin Z, Tavasolli E, Thatcher G. O2-05-06: Mechanistic investigation of nitrate chimeras for Alzheimer's disease Alzheimer's & Dementia. 8: P244-P244. DOI: 10.1016/J.Jalz.2012.05.653  0.241
2023 Petukhova VZ, Aboagye SY, Ardini M, Lullo RP, Fata F, Byrne ME, Gabriele F, Martin LM, Harding LNM, Gone V, Dangi B, Lantvit DD, Nikolic D, Ippoliti R, Effantin G, ... ... Thatcher GRJ, et al. Non-covalent inhibitors of thioredoxin glutathione reductase with schistosomicidal activity in vivo. Nature Communications. 14: 3737. PMID 37349300 DOI: 10.1038/s41467-023-39444-y  0.241
2006 Thatcher GR, Bennett BM, Reynolds JN. NO chimeras as therapeutic agents in Alzheimer's disease. Current Alzheimer Research. 3: 237-45. PMID 16842101 DOI: 10.2174/156720506777632925  0.24
2020 Dudek AZ, Liu LC, Fischer JH, Wiley EL, Sachdev JC, Bleeker J, Hurley RW, Tonetti DA, Thatcher GRJ, Venuti RP, O'Regan RM. Phase 1 study of TTC-352 in patients with metastatic breast cancer progressing on endocrine and CDK4/6 inhibitor therapy. Breast Cancer Research and Treatment. PMID 32696319 DOI: 10.1007/S10549-020-05787-Z  0.239
2023 Ratia KM, Shen Z, Gordon-Blake J, Lee H, Laham MS, Krider IS, Christie N, Ackerman-Berrier M, Penton C, Knowles NG, Musku SR, Fu J, Velma GR, Xiong R, Thatcher GRJ. Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD. Biochemistry. PMID 36746631 DOI: 10.1021/acs.biochem.2c00655  0.236
2022 Lewandowski CT, Laham MS, Thatcher GRJ. Remembering your A, B, C's: Alzheimer's disease and ABCA1. Acta Pharmaceutica Sinica. B. 12: 995-1018. PMID 35530134 DOI: 10.1016/j.apsb.2022.01.011  0.234
2018 Hollas MA, Ben Aissa M, Lee SH, Gordon-Blake JM, Thatcher GRJ. Pharmacological manipulation of cGMP and NO/cGMP in CNS drug discovery. Nitric Oxide : Biology and Chemistry. PMID 30394348 DOI: 10.1016/j.niox.2018.10.006  0.233
2015 Ziniel PD, Karumudi B, Barnard AH, Fisher EM, Thatcher GR, Podust LM, Williams DL. The Schistosoma mansoni Cytochrome P450 (CYP3050A1) Is Essential for Worm Survival and Egg Development. Plos Neglected Tropical Diseases. 9: e0004279. PMID 26713732 DOI: 10.1371/journal.pntd.0004279  0.233
2020 Li Y, Zhao J, Gutgesell L, Shen Z, Ratia K, Dye K, Dubrovyskyii O, Zhao H, Huang F, Tonetti DA, Thatcher GR, Xiong R. Novel pyrrolopyridone bromodomain and extra-terminal motif (BET) inhibitors effective in endocrine-resistant ER+ breast cancer with acquired resistance to fulvestrant and palbociclib. Journal of Medicinal Chemistry. PMID 32453591 DOI: 10.1021/Acs.Jmedchem.0C00456  0.233
2004 Thatcher GR, Bennett BM, Dringenberg HC, Reynolds JN. Novel nitrates as NO mimetics directed at Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 6: S75-84. PMID 15665418 DOI: 10.3233/Jad-2004-6S614  0.229
2021 Fata F, Silvestri I, Ardini M, Ippoliti R, Di Leandro L, Demitri N, Polentarutti M, Di Matteo A, Lyu H, Thatcher GRJ, Petukhov PA, Williams DL, Angelucci F. Probing the Surface of a Parasite Drug Target Thioredoxin Glutathione Reductase Using Small Molecule Fragments. Acs Infectious Diseases. PMID 33950676 DOI: 10.1021/acsinfecdis.0c00909  0.228
2009 Yu B, Qin Z, Wijewickrama GT, Edirisinghe P, Bolton JL, Thatcher GR. Comparative methods for analysis of protein covalent modification by electrophilic quinoids formed from xenobiotics. Bioconjugate Chemistry. 20: 728-41. PMID 19301905 DOI: 10.1021/Bc800435M  0.226
2015 Siklos M, BenAissa M, Thatcher GR. Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors. Acta Pharmaceutica Sinica. B. 5: 506-19. PMID 26713267 DOI: 10.1016/j.apsb.2015.08.001  0.225
2014 Molloy ME, White BE, Gherezghiher T, Michalsen BT, Xiong R, Patel H, Zhao H, Maximov PY, Jordan VC, Thatcher GR, Tonetti DA. Novel selective estrogen mimics for the treatment of tamoxifen-resistant breast cancer. Molecular Cancer Therapeutics. 13: 2515-26. PMID 25205655 DOI: 10.1158/1535-7163.Mct-14-0319  0.225
2020 Lyu H, Petukhov PA, Banta PR, Jadhav A, Lea W, Cheng Q, Arner ESJ, Simeonov A, Thatcher GR, Angelucci F, Williams DL. Characterization of lead compounds targeting the selenoprotein thioredoxin glutathione reductase for treatment of schistosomiasis. Acs Infectious Diseases. PMID 31939288 DOI: 10.1021/Acsinfecdis.9B00354  0.224
2001 Artz JD, Toader V, Zavorin SI, Bennett BM, Thatcher GRJ. In vitro activation of soluble guanylyl cyclase and nitric oxide release: A comparison of NO donors and NO mimetics Biochemistry. 40: 9256-9264. PMID 11478893 DOI: 10.1021/bi002885x  0.223
2014 Koster K, LaDu MJ, Luo J, Thatcher G, Tai L. P4-360: INTERACTIONS OF APOE GENOTYPE AND RXR AGONISTS ON SOLUBLE AB AND OLIGOMERIC AB Alzheimer's & Dementia. 10: P920-P921. DOI: 10.1016/J.Jalz.2014.07.130  0.223
2024 Li Y, Shen Z, Ratia K, Zhao J, Huang F, Dubrovyskyii O, Indukuri D, Fu J, Lozano Ramos O, Thatcher GRJ, Xiong R. Structure-Guided Design and Synthesis of Pyridinone-Based Selective Bromodomain and Extra-Terminal Domain (BET)-First Bromodomain (BD1) Inhibitors. Journal of Medicinal Chemistry. PMID 38295759 DOI: 10.1021/acs.jmedchem.3c01837  0.221
2012 Hickok JR, Vasudevan D, Thatcher GR, Thomas DD. Is S-nitrosocysteine a true surrogate for nitric oxide? Antioxidants & Redox Signaling. 17: 962-8. PMID 22304688 DOI: 10.1089/ars.2012.4543  0.22
2017 Taha TY, Aboukhatwa SM, Knopp RC, Ikegaki N, Abdelkarim H, Neerasa J, Lu Y, Neelarapu R, Hanigan TW, Thatcher GRJ, Petukhov PA. Design, Synthesis, and Biological Evaluation of Tetrahydroisoquinoline-Based Histone Deacetylase 8 Selective Inhibitors. Acs Medicinal Chemistry Letters. 8: 824-829. PMID 28835796 DOI: 10.1021/acsmedchemlett.7b00126  0.219
2009 Wang Z, Wijewickrama GT, Peng KW, Dietz BM, Yuan L, van Breemen RB, Bolton JL, Thatcher GR. Estrogen Receptor {alpha} Enhances the Rate of Oxidative DNA Damage by Targeting an Equine Estrogen Catechol Metabolite to the Nucleus. The Journal of Biological Chemistry. 284: 8633-42. PMID 19158089 DOI: 10.1074/Jbc.M807860200  0.216
2021 Singh SK, Kumar S, Viswakarma N, Principe DR, Das S, Sondarva G, Nair RS, Srivastava P, Sinha SC, Grippo PJ, Thatcher GRJ, Rana B, Rana A. MAP4K4 promotes pancreatic tumorigenesis via phosphorylation and activation of mixed lineage kinase 3. Oncogene. PMID 34511598 DOI: 10.1038/s41388-021-02007-w  0.216
2021 Schafer A, Xiong R, Cooper L, Nowar R, Lee H, Li Y, Ramirez BE, Peet NP, Caffrey M, Thatcher GRJ, Saphire EO, Cheng H, Rong L. Evidence for distinct mechanisms of small molecule inhibitors of filoviral entry. Plos Pathogens. 17: e1009312. PMID 33539432 DOI: 10.1371/journal.ppat.1009312  0.214
2021 Lewandowski CT, Khan MW, BenAissa M, Dubrovskyi O, Ackerman-Berrier M, LaDu MJ, Layden BT, Thatcher GRJ. Metabolomic analysis of a selective ABCA1 inducer in obesogenic challenge provides a rationale for therapeutic development. Ebiomedicine. 66: 103287. PMID 33752129 DOI: 10.1016/j.ebiom.2021.103287  0.213
2023 Shen Z, Ratia K, Krider I, Ackerman-Berrier M, Penton C, Musku SR, Gordon-Blake JM, Laham MS, Christie N, Ma N, Fu J, Xiong R, Courey JM, Velma GR, Thatcher GRJ. Synthesis, Optimization, and Structure-Activity Relationships of Nicotinamide Phosphoribosyltransferase (NAMPT) Positive Allosteric Modulators (N-PAMs). Journal of Medicinal Chemistry. PMID 38096366 DOI: 10.1021/acs.jmedchem.3c01406  0.21
2021 Ben Aissa M, Lewandowski CT, Ratia KM, Lee SH, Layden BT, LaDu MJ, Thatcher GRJ. Discovery of Nonlipogenic ABCA1 Inducing Compounds with Potential in Alzheimer's Disease and Type 2 Diabetes. Acs Pharmacology & Translational Science. 4: 143-154. PMID 33615168 DOI: 10.1021/acsptsci.0c00149  0.205
2011 Pathi SS, Jutooru I, Chadalapaka G, Sreevalsan S, Anand S, Thatcher GR, Safe S. GT-094, a NO-NSAID, inhibits colon cancer cell growth by activation of a reactive oxygen species-microRNA-27a: ZBTB10-specificity protein pathway. Molecular Cancer Research : McR. 9: 195-202. PMID 21156786 DOI: 10.1158/1541-7786.Mcr-10-0363  0.204
2012 Qin Z, Luo J, VandeVrede L, Tavassoli E, Fa' M, Teich AF, Arancio O, Thatcher GR. Design and synthesis of neuroprotective methylthiazoles and modification as NO-chimeras for neurodegenerative therapy. Journal of Medicinal Chemistry. 55: 6784-801. PMID 22779770 DOI: 10.1021/Jm300353R  0.203
2020 Jastaniah A, Gaisina IN, Knopp RC, Thatcher GRJ. Synthesis of α-Ketoamide-Based Stereoselective Calpain-1 Inhibitors as Neuroprotective Agents. Chemmedchem. PMID 32840034 DOI: 10.1002/cmdc.202000385  0.202
2014 Patel HK, Siklos MI, Abdelkarim H, Mendonca EL, Vaidya A, Petukhov PA, Thatcher GRJ. Cover Picture: A Chimeric SERM-Histone Deacetylase Inhibitor Approach to Breast Cancer Therapy (ChemMedChem 3/2014) Chemmedchem. 9: 413-413. DOI: 10.1002/Cmdc.201490005  0.202
1996 Vizitiu D, Kriste AG, Campbell AS, Thatcher GR. Inhibition of phosphatidylinositol-specific phospholipase C: studies on synthetic substrates, inhibitors and a synthetic enzyme. Journal of Molecular Recognition : Jmr. 9: 197-209. PMID 8877813 DOI: 10.1002/(SICI)1099-1352(199603)9:2<197::AID-JMR263>3.0.CO;2-X  0.201
2021 Knopp RC, Jastaniah A, Dubrovskyi O, Gaisina I, Tai L, Thatcher GRJ. Extending the Calpain-Cathepsin Hypothesis to the Neurovasculature: Protection of Brain Endothelial Cells and Mice from Neurotrauma. Acs Pharmacology & Translational Science. 4: 372-385. PMID 33615187 DOI: 10.1021/acsptsci.0c00217  0.2
2001 Zavorin SI, Artz JD, Dumitrascu A, Nicolescu A, Scutaru D, Smith SV, Thatcher GR. Nitrate esters as nitric oxide donors: SS-nitrates. Organic Letters. 3: 1113-6. PMID 11348172 DOI: 10.1021/ol007022a  0.2
2010 Wang Z, Chandrasena ER, Yuan Y, Peng KW, van Breemen RB, Thatcher GR, Bolton JL. Redox cycling of catechol estrogens generating apurinic/apyrimidinic sites and 8-oxo-deoxyguanosine via reactive oxygen species differentiates equine and human estrogens. Chemical Research in Toxicology. 23: 1365-73. PMID 20509668 DOI: 10.1021/Tx1001282  0.199
1997 Gorin BI, Ferguson CG, Thatcher GRJ. A novel esterification procedure applied to synthesis of biologically active esters of Foscarnet Tetrahedron Letters. 38: 2791-2794. DOI: 10.1016/S0040-4039(97)00491-7  0.198
1997 McCracken PG, Bolton JL, Thatcher GRJ. Covalent Modification of Proteins and Peptides by the Quinone Methide from 2-tert-Butyl-4,6-dimethylphenol: Selectivity and Reactivity with Respect to Competitive Hydration Journal of Organic Chemistry. 62: 1820-1825. DOI: 10.1021/Jo962088Y  0.198
2012 Gherezghiher TB, Michalsen B, Chandrasena RE, Qin Z, Sohn J, Thatcher GR, Bolton JL. The naphthol selective estrogen receptor modulator (SERM), LY2066948, is oxidized to an o-quinone analogous to the naphthol equine estrogen, equilenin. Chemico-Biological Interactions. 196: 1-10. PMID 22290292 DOI: 10.1016/J.Cbi.2012.01.004  0.198
2017 Bhattacharjee A, Sinha A, Ratia K, Yin L, Delgado-Rivera L, Petukhov PA, Thatcher GRJ, Wardrop DJ. 2-Arylidene Hydrazinecarbodithioates as Potent, Selective Inhibitors of Cystathionine γ-Lyase (CSE). Acs Medicinal Chemistry Letters. 8: 1241-1245. PMID 29259741 DOI: 10.1021/Acsmedchemlett.7B00313  0.194
2003 DiFabio J, Ji Y, Vasiliou V, Thatcher GR, Bennett BM. Role of mitochondrial aldehyde dehydrogenase in nitrate tolerance. Molecular Pharmacology. 64: 1109-16. PMID 14573760 DOI: 10.1124/Mol.64.5.1109  0.192
2020 Kumar S, Singh SK, Viswakarma N, Sondarva G, Nair RS, Sethupathi P, Sinha SC, Emmadi R, Hoskins K, Danciu O, Thatcher GRJ, Rana B, Rana A. Mixed lineage kinase 3 inhibition induces T cell activation and cytotoxicity. Proceedings of the National Academy of Sciences of the United States of America. PMID 32209667 DOI: 10.1073/Pnas.1921325117  0.191
2001 Murray J, Macartney D, Thatcher GRJ. Catalysis of NO production by a molybdoenzyme model Organic Letters. 3: 3635-3638. PMID 11700100 DOI: 10.1021/Ol0165701  0.188
2009 Wang Z, Edirisinghe P, Sohn J, Qin Z, Geacintov NE, Thatcher GR, Bolton JL. Development of a liquid chromatography electrospray ionization tandem mass spectrometry method for analysis of stable 4-hydroxyequilenin-DNA adducts in human breast cancer cells. Chemical Research in Toxicology. 22: 1129-36. PMID 19368368 DOI: 10.1021/Tx900063G  0.188
2016 Ben Aissa M, Lee SH, Bennett BM, Thatcher GR. Targeting NO/cGMP Signaling in the CNS for Neurodegeneration and Alzheimer's Disease. Current Medicinal Chemistry. 23: 2770-2788. PMID 27776476  0.183
2014 Wang YT, Piyankarage SC, Williams DL, Thatcher GR. Proteomic profiling of nitrosative stress: protein S-oxidation accompanies S-nitrosylation. Acs Chemical Biology. 9: 821-30. PMID 24397869 DOI: 10.1021/Cb400547U  0.182
1996 Artz JD, Yang K, Lock J, Sanchez C, Bennett BM, Thatcher GRJ. Reactivity of thionitrate esters: Putative intermediates in nitrovasodilator activity Chemical Communications. 927-928.  0.178
1998 Thatcher GRJ, Weldon H. NO problem for nitroglycerin: Organic nitrate chemistry and therapy Chemical Society Reviews. 27: 331-337.  0.177
1987 Blackburn GM, Thatcher GRJ, Hosseini MW, Lehn JM. Evidence for a protophosphatase catalysed cleavage of adenosine triphosphate by a dissociative-type mechanism within a receptor-substrate complex Tetrahedron Letters. 28: 2779-2782. DOI: 10.1016/S0040-4039(00)96208-7  0.176
1999 Ferguson CG, Thatcher GRJ. Catalysis and acceleration of acyl transfer by aminocyclodextrins: A biomimetic system of use in enzyme modeling and drug design Organic Letters. 1: 829-832. PMID 10823212  0.172
2020 Gaisina IN, Peet NP, Wong L, Schafer AM, Cheng H, Anantpadma M, Davey RA, Thatcher GR, Rong L. Discovery and Structural Optimization of 4-(Aminomethyl)benzamides as Potent Entry Inhibitors of Ebola and Marburg Virus Infections. Journal of Medicinal Chemistry. PMID 32490678 DOI: 10.1021/Acs.Jmedchem.0C00463  0.171
2010 Thatcher GR, Abdelhamid R, Luo J, Qin Z. O4-07-08: Design of selective estrogen receptor modulators as neuroprotective and procognitive agents Alzheimer's & Dementia. 6: S165-S165. DOI: 10.1016/j.jalz.2010.05.511  0.171
2006 Nicolescu AC, Li Q, Brown L, Thatcher GR. Nitroxidation, nitration, and oxidation of a BODIPY fluorophore by RNOS and ROS. Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. 15: 163-76. PMID 16549377 DOI: 10.1016/j.niox.2006.01.010  0.171
2023 Valencia-Olvera AC, Balu D, Faulk N, Amiridis A, Wang Y, Pham C, Avila-Munoz E, York JM, Thatcher GRJ, LaDu MJ. Inhibition of ACAT as a Therapeutic Target for Alzheimer's Disease Is Independent of ApoE4 Lipidation. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 37157042 DOI: 10.1007/s13311-023-01375-3  0.169
2002 Nicolescu AC, Zavorin SI, Turro NJ, Reynolds JN, Thatcher GR. Inhibition of lipid peroxidation in synaptosomes and liposomes by nitrates and nitrites. Chemical Research in Toxicology. 15: 985-98. PMID 12119011 DOI: 10.1021/Tx025529J  0.167
2016 Wang YT, Piyankarage SC, Thatcher GRJ. Quantitative profiling of reversible cysteome modification under nitrosative stress Neuromethods. 114: 55-72. DOI: 10.1007/7657_2015_88  0.164
2006 Dowers TS, Qin ZH, Thatcher GR, Bolton JL. Bioactivation of Selective Estrogen Receptor Modulators (SERMs). Chemical Research in Toxicology. 19: 1125-37. PMID 16978016 DOI: 10.1021/Tx060126V  0.163
2014 Tai LM, Koster KP, Luo J, Lee SH, Wang YT, Collins NC, Ben Aissa M, Thatcher GR, LaDu MJ. Amyloid-β pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo. The Journal of Biological Chemistry. 289: 30538-55. PMID 25217640 DOI: 10.1074/jbc.M114.600833  0.163
2017 Ben Aissa M, Tipton AF, Bertels Z, Gandhi R, Moye LS, Novack M, Bennett BM, Wang Y, Litosh V, Lee SH, Gaisina IN, Thatcher GR, Pradhan AA. Soluble guanylyl cyclase is a critical regulator of migraine-associated pain. Cephalalgia : An International Journal of Headache. 333102417737778. PMID 29022756 DOI: 10.1177/0333102417737778  0.163
2024 Gordon-Blake J, Ratia K, Weidig V, Velma GR, Ackerman-Berrier M, Penton C, Musku SR, Alves ETM, Driver T, Tai L, Thatcher GRJ. Nicotinamide Phosphoribosyltransferase Positive Allosteric Modulators Attenuate Neuronal Oxidative Stress. Acs Medicinal Chemistry Letters. 15: 205-214. PMID 38352833 DOI: 10.1021/acsmedchemlett.3c00391  0.162
2016 Koster KP, Smith C, Valencia-Olvera AC, Thatcher GR, LaDu MJ, Tai LM. Rexinoids as therapeutics for Alzheimer disease: Role of APOE. Current Topics in Medicinal Chemistry. PMID 27320328  0.161
1996 Yang K, Artz JD, Lock J, Sanchez C, Bennett BM, Fraser AB, Thatcher GRJ. Synthesis of novel organic nitrate esters: Guanylate cyclase activation and tissue relaxation Journal of the Chemical Society - Perkin Transactions 1. 1073-1075.  0.158
2021 Shen Z, Ratia K, Cooper L, Kong D, Lee H, Kwon Y, Li Y, Alqarni S, Huang F, Dubrovskyi O, Rong L, Thatcher GRJ, Xiong R. Design of SARS-CoV-2 PLpro Inhibitors for COVID-19 Antiviral Therapy Leveraging Binding Cooperativity. Journal of Medicinal Chemistry. PMID 34665619 DOI: 10.1021/acs.jmedchem.1c01307  0.156
2014 Vandevrede L, Tavassoli E, Luo J, Qin Z, Yue L, Pepperberg DR, Thatcher GR. Novel analogues of chlormethiazole are neuroprotective in four cellular models of neurodegeneration by a mechanism with variable dependence on GABA(A) receptor potentiation. British Journal of Pharmacology. 171: 389-402. PMID 24116891 DOI: 10.1111/Bph.12454  0.155
2004 Nicolescu AC, Reynolds JN, Barclay LR, Thatcher GR. Organic nitrites and NO: inhibition of lipid peroxidation and radical reactions. Chemical Research in Toxicology. 17: 185-96. PMID 14967006 DOI: 10.1021/tx034097p  0.155
2021 Scheinman SB, Zaldua S, Dada A, Krochmaliuk K, Dye K, Marottoli FM, Thatcher GRJ, Tai LM. Systemic Candesartan Treatment Modulates Behavior, Synaptic Protein Levels, and Neuroinflammation in Female Mice That Express Human . Frontiers in Neuroscience. 15: 628403. PMID 33642985 DOI: 10.3389/fnins.2021.628403  0.155
2000 Ferguson CG, Gorin BI, Thatcher GRJ. Design of novel derivatives of phosphonoformate (Foscarnet) as prodrugs and antiviral agents Journal of Organic Chemistry. 65: 1218-1221. PMID 10814076 DOI: 10.1021/jo9912909  0.155
2022 Alqarni S, Cooper L, Galvan Achi J, Bott R, Sali VK, Brown A, Santarsiero BD, Krunic A, Manicassamy B, Peet NP, Zhang P, Thatcher GRJ, Gaisina IN, Rong L, Moore TW. Synthesis, Optimization, and Structure-Activity Relationships of Imidazo[1,2-]pyrimidines as Inhibitors of Group 2 Influenza A Viruses. Journal of Medicinal Chemistry. PMID 36260129 DOI: 10.1021/acs.jmedchem.2c01329  0.153
1991 Stewart Campbell A, Thatcher GRJ. Synthesis of an analogue of D,L-MYO-inositol-1,2-cyclic phosphate: inhibition of phosphatidylinositol-specific phospholipase C Tetrahedron Letters. 32: 2207-2210. DOI: 10.1016/S0040-4039(00)79682-1  0.153
2007 May M, Mehboob S, Mulhearn DC, Wang Z, Yu H, Thatcher GR, Santarsiero BD, Johnson ME, Mesecar AD. Structural and functional analysis of two glutamate racemase isozymes from Bacillus anthracis and implications for inhibitor design. Journal of Molecular Biology. 371: 1219-37. PMID 17610893 DOI: 10.1016/J.Jmb.2007.05.093  0.153
2012 Overk CR, Lu PY, Wang YT, Choi J, Shaw JW, Thatcher GR, Mufson EJ. Effects of aromatase inhibition versus gonadectomy on hippocampal complex amyloid pathology in triple transgenic mice. Neurobiology of Disease. 45: 479-87. PMID 21945538 DOI: 10.1016/j.nbd.2011.08.035  0.151
2016 Yao Y, Kong C, Yin L, Jain AD, Ratia K, Thatcher GR, Moore TW, Driver T, Miller LW. Time-gated detection of cystathionine γ-lyase activity and inhibition with a selective, luminogenic hydrogen sulfide sensor. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27734530 DOI: 10.1002/Chem.201604786  0.15
2007 Bennett BM, Reynolds JN, Prusky GT, Douglas RM, Sutherland RJ, Thatcher GR. Cognitive deficits in rats after forebrain cholinergic depletion are reversed by a novel NO mimetic nitrate ester. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 505-13. PMID 16525416 DOI: 10.1038/sj.npp.1301054  0.149
2020 Knopp RC, Lee SH, Hollas M, Nepomuceno E, Gonzalez D, Tam K, Aamir D, Wang Y, Pierce E, BenAissa M, Thatcher GRJ. Interaction of oxidative stress and neurotrauma in ALDH2 mice causes significant and persistent behavioral and pro-inflammatory effects in a tractable model of mild traumatic brain injury. Redox Biology. 32: 101486. PMID 32155582 DOI: 10.1016/J.Redox.2020.101486  0.146
2010 Bolton JL, Thatcher GRJ. Genotoxic Estrogen Pathway: Endogenous and Equine Estrogen Hormone Replacement Therapy The Chemical Biology of Dna Damage. 185-199. DOI: 10.1002/9783527630110.ch8  0.143
1998 Ferguson CG, Thatcher GRJ. A simple synthesis of phosphonoformamides Synlett. 1325-1326.  0.142
2000 Smith S, Dringenberg HC, Bennett BM, Thatcher GR, Reynolds JN. A novel nitrate ester reverses the cognitive impairment caused by scopolamine in the Morris water maze. Neuroreport. 11: 3883-6. PMID 11117508 DOI: 10.1097/00001756-200011270-00055  0.13
2019 Taha TY, Aboukhatwa SM, Knopp RC, Ikegaki N, Abdelkarim H, Neerasa J, Lu Y, Neelarapu R, Hanigan TW, Thatcher GRJ, Petukhov PA. Correction to Design, Synthesis, and Biological Evaluation of Tetrahydroisoquinoline-Based Histone Deacetylase 8 Selective Inhibitors. Acs Medicinal Chemistry Letters. 10: 1358. PMID 31531211 DOI: 10.1021/acsmedchemlett.9b00336  0.129
2001 Lei S, Orser BA, Thatcher GR, Reynolds JN, MacDonald JF. Positive allosteric modulators of AMPA receptors reduce proton-induced receptor desensitization in rat hippocampal neurons. Journal of Neurophysiology. 85: 2030-8. PMID 11353019 DOI: 10.1152/jn.2001.85.5.2030  0.127
2004 Wang Z, Chang L, Klein WL, Thatcher GR, Venton DL. Per-6-substituted-per-6-deoxy beta-cyclodextrins inhibit the formation of beta-amyloid peptide derived soluble oligomers. Journal of Medicinal Chemistry. 47: 3329-33. PMID 15189029 DOI: 10.1021/Jm034224E  0.126
1998 Artz JD, Thatcher GRJ. NO release from NO donors and nitrovasodilators: Comparisons between oxyhemoglobin and potentiometric assays Chemical Research in Toxicology. 11: 1393-1397. PMID 9860479 DOI: 10.1021/tx980205+  0.124
2022 Chen H, Lu Y, Xiong R, Rosales CI, Coles C, Hamada K, Asad N, Thatcher GRJ, Lasek AW. Effect of a brain-penetrant selective estrogen receptor degrader (SERD) on binge drinking in female mice. Alcoholism, Clinical and Experimental Research. PMID 35581531 DOI: 10.1111/acer.14874  0.123
2010 Kim HY, Sohn J, Wijewickrama GT, Edirisinghe P, Gherezghiher T, Hemachandra M, Lu PY, Chandrasena RE, Molloy ME, Tonetti DA, Thatcher GR. Click synthesis of estradiol-cyclodextrin conjugates as cell compartment selective estrogens. Bioorganic & Medicinal Chemistry. 18: 809-21. PMID 20031420 DOI: 10.1016/J.Bmc.2009.11.046  0.122
1992 Stewart Campbell A, Thatcher GRJ. Tetravanadate is an inhibitor of phosphatidyl inositol-specific phospholipase C Bioorganic and Medicinal Chemistry Letters. 2: 655-658. DOI: 10.1016/S0960-894X(00)80384-4  0.118
2011 Wang Y, Piyankarage SC, Thatcher GR. Quantitative Proteomic Analysis of Protein Cysteome Modification in Response To Nitric Oxide (NO) Donors Using D-Sswitch Free Radical Biology and Medicine. 51: S165. DOI: 10.1016/J.Freeradbiomed.2011.10.235  0.118
1995 Chan SSC, Szarek WA, Thatcher GRJ. The reverse anomeric effect in N-pyranosylimidazolides: A molecular orbital study Journal of the Chemical Society, Perkin Transactions 2. 45-60. DOI: 10.1039/P29950000045  0.114
2013 Thatcher GR, Luo J, VandeVrede L, Qin Z, Lee S, Abdelhamid R, Bennett BM, Jo LaDu M, Tai L, Larson J. NO/cGMP/pCREB re-activation reverses cognition deficits and attenuates amyloid-β neuropathology in transgenic models of Alzheimer’s disease Bmc Pharmacology and Toxicology. 14. DOI: 10.1186/2050-6511-14-S1-P72  0.112
2016 Luo J, Lee SH, VandeVrede L, Qin Z, Aissa MB, Larson J, Teich AF, Arancio O, D'Souza Y, Elharram A, Koster K, Tai LM, LaDu MJ, Bennett BM, Thatcher GR. Erratum to: A multifunctional therapeutic approach to disease modification in multiple familial mouse models and a novel sporadic model of Alzheimer's disease. Molecular Neurodegeneration. 11: 40. PMID 27194246 DOI: 10.1186/S13024-016-0104-5  0.111
1988 BLACKBURN GM, TAYLOR GE, TATTERSHALL RH, THATCHER GRJ, MCLENNAN A. ChemInform Abstract: Phosphonate Analogs of Biological Phosphates Cheminform. 19. DOI: 10.1002/chin.198812390  0.107
1996 Kriste AG, Vizitiu D, Thatcher GRJ. A metallomicelle enzyme model for phospholipase C catalysis and inhibition Chemical Communications. 913-914.  0.107
1994 Thatcher GRJ, Krol ES, Cameron DR. Stereoelectronic effects in pentacoordinate intermediates and acceleration of nucleophilic substitution at phosphorus Journal of the Chemical Society, Perkin Transactions 2. 683-690.  0.106
1995 Pregel MJ, Dunn EJ, Nagelkerke R, Thatcher GRJ, Buncel E. Alkali–metal lon catalysis and inhibition in nucleophilic displacement reaction of phosphorus–sulfur–and carbon–based esters Chem. Soc. Rev.. 24: 449-455. DOI: 10.1039/Cs9952400449  0.105
1997 Borrajo AMP, Gal J, Maria P, Decouzon M, Ripley DC, Buncel E, Thatcher GRJ. Gas-Phase Cation Basicities for Sulfuryl Species from Calculation and Experiment† The Journal of Organic Chemistry. 62: 9203-9209. DOI: 10.1021/Jo9713971  0.104
1987 Blackburn GM, Taylor GE, Thatcher GR, Prescott M, McLennan AG. Synthesis and resistance to enzymic hydrolysis of stereochemically-defined phosphonate and thiophosphate analogues of P1,P4-bis(5'-adenosyl) tetraphosphate. Nucleic Acids Research. 15: 6991-7004. PMID 2821489 DOI: 10.1093/nar/15.17.6991  0.103
2002 Reynolds JN, Bennett BM, Boegman RJ, Jhamandas K, Ratz JD, Zavorin SI, Scutaru D, Dumitrascu A, Thatcher GR. Neuroprotection against ischemic brain injury conferred by a novel nitrate ester. Bioorganic & Medicinal Chemistry Letters. 12: 2863-6. PMID 12270164 DOI: 10.1016/S0960-894X(02)00631-5  0.103
2020 Gaisina IN, Peet N, Cheng H, Li P, Du R, Cui Q, Furlong K, Manicassamy B, Caffrey M, Thatcher GR, Rong L. Optimization of 4-aminopiperidines as inhibitors of influenza A viral entry that are synergistic with oseltamivir. Journal of Medicinal Chemistry. PMID 32069052 DOI: 10.1021/Acs.Jmedchem.9B01900  0.098
2017 Yao Y, Delgado-Rivera L, Samareh Afsari H, Yin L, Thatcher GRJ, Moore TW, Miller LW. Time-Gated Luminescence Detection of Enzymatically Produced Hydrogen Sulfide: Design, Synthesis, and Application of a Lanthanide-Based Probe. Inorganic Chemistry. PMID 29281273 DOI: 10.1021/Acs.Inorgchem.7B02533  0.098
1997 Borrajo AMP, Gorin BI, Dostaler SM, Riopelle RJ, Thatcher GRJ. Derivatized cyclodextrins as peptidomimetics: Influence on neurite growth Bioorganic and Medicinal Chemistry Letters. 7: 1185-1190. DOI: 10.1016/S0960-894X(97)00180-7  0.098
2007 Marchand WR, Lee JN, Thatcher J, Thatcher GW, Jensen C, Starr J. An fMRI study of frontal-subcortical skeletomotor circuit and dorsolateral prefrontal cortex function using a paced motor activation paradigm Brain Imaging and Behavior. 1: 58-67. DOI: 10.1007/s11682-007-9006-z  0.097
2007 Marchand WR, Lee JN, Thatcher J, Thatcher GW, Jensen C, Starr J. A preliminary longitudinal fMRI study of frontal-subcortical circuits in bipolar disorder using a paced motor activation paradigm. Journal of Affective Disorders. 103: 237-41. PMID 17316821 DOI: 10.1016/j.jad.2007.01.008  0.095
1980 Chinn DM, Jennison TA, Crouch DJ, Peat MA, Thatcher GW. Quantitative analysis for tricyclic antidepressant drugs in plasma or serum by gas chromatography-chemical-ionization mass spectrometry Clinical Chemistry. 26: 1201-1204. PMID 7389093  0.094
1983 Moulsdale MT, Harper JM, Thatcher GN, Dunn BL. Infection by Mycobacterium haemophilum, a metabolically fastidious acid-fast bacillus Tubercle. 64: 29-36. PMID 6845432 DOI: 10.1016/0041-3879(83)90047-8  0.093
2003 Akhter S, Green JR, Root P, Thatcher GJ, Mutus B. Peroxynitrite and NO+ donors form colored nitrite adducts with sinapinic acid: potential applications. Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. 8: 214-21. PMID 12895430 DOI: 10.1016/S1089-8603(03)00031-4  0.091
1992 Thatcher GRJ, Cameron DR, Nagelkerke R, Schmitke J. Selective hydrogen bonding as a mechanism for differentiation of sulfate and phosphate at biomolecular receptor sites Journal of the Chemical Society, Chemical Communications. 386-388. DOI: 10.1039/C39920000386  0.089
1997 Vizitiu D, Walkinshaw CS, Gorin BI, Thatcher GRJ. Synthesis of monofacially functionalized cyclodextrins bearing amino pendent groups Journal of Organic Chemistry. 62: 8760-8766. DOI: 10.1021/jo9711549  0.088
1993 Thatcher GRJ, Campbell AS. Phosphonates as mimics of phosphate biomolecules: Ab initio calculations on tetrahedral ground states and pentacoordinate intermediates for phosphoryl transfer Journal of Organic Chemistry. 58: 2272-2281.  0.086
1993 Krol ES, Thatcher GRJ. Hydrolysis of phosphonoformate triesters: Rate acceleration of a millionfold in nucleophilic substitution at phosphorus Journal of the Chemical Society, Perkin Transactions 2. 793-794.  0.083
1999 Vizitiu D, Thatcher GRJ. Binding of phosphates to aminocyclodextrin biomimetics Journal of Organic Chemistry. 64: 6235-6238. DOI: 10.1021/jo9902392  0.083
1992 Ng K, Trotter J, Metcalf C, Thatcher G, Marshall E. Extranodal Ki-1 lymphoma in a renal transplant patient Australian and New Zealand Journal of Medicine. 22: 51-53. PMID 1580865  0.081
2020 Yu L, Tasaki S, Schneider JA, Arfanakis K, Duong DM, Wingo AP, Wingo TS, Kearns N, Thatcher GRJ, Seyfried NT, Levey AI, De Jager PL, Bennett DA. Cortical Proteins Associated With Cognitive Resilience in Community-Dwelling Older Persons. Jama Psychiatry. PMID 32609320 DOI: 10.1001/Jamapsychiatry.2020.1807  0.081
1988 Lowe G, Thatcher GRJ, Turner JCG, Waller A, Watkin DJ. Stereoelectronic effects in sulfate diesters and sulfuric acid Journal of the American Chemical Society. 110: 8512-8520. DOI: 10.1021/Ja00233A030  0.078
2003 Nagelkerke R, Thatcher GR, Buncel E. Alkali-metal ion catalysis and inhibition in nucleophilic displacement reactions at carbon, phosphorus and sulfur centres. IX. p-Nitrophenyl diphenyl phosphate. Organic & Biomolecular Chemistry. 1: 163-7. PMID 12929405 DOI: 10.1039/B208408B  0.077
1994 Palmer DRJ, Buncel E, Thatcher GRJ. Re-Evaluation of Cyclodextrin as a Model of Chymotrypsin: Acceleration and Inhibition of Tertiary Anilide Hydrolysis The Journal of Organic Chemistry. 59: 5286-5291. DOI: 10.1021/Jo00097A034  0.077
1996 Parnham AP, Thatcher GN. Pregnancy and active Wegener Granulomatosis Australian and New Zealand Journal of Obstetrics and Gynaecology. 36: 361-363. PMID 8883770  0.077
2007 Marchand WR, Lee JN, Thatcher GW, Jensen C, Stewart D, Dilda V, Thatcher J, Creem-Regehr SH. A functional MRI study of a paced motor activation task to evaluate frontal-subcortical circuit function in bipolar depression. Psychiatry Research. 155: 221-30. PMID 17588725 DOI: 10.1016/J.Pscychresns.2007.03.003  0.077
1995 Thatcher GW, Cates M, Bair B. Clozapine-induced toxic hepatitis [4] American Journal of Psychiatry. 152: 296-297. PMID 7840371  0.076
1964 THATCHER GN, DREOSTI JM, BROCK JF. OBSERVATIONS ON THE EFFECTS OF THE ADDITION OF DIFFERENT LEVELS OF SODIUM CHLORIDE TO A PROTEIN-DEPLETION DIET. South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde. 38: 682-4. PMID 14195932  0.074
1994 Palmer DRJ, Buncel E, Thatcher GRJ. Re-evaluation of cyclodextrin as a model of chymotrypsin: Acceleration and inhibition of tertiary anilide hydrolysis Journal of Organic Chemistry. 59: 5286-5291.  0.072
1996 Cameron DR, Thatcher GRJ. Mechanisms of reaction of sulfate esters: A molecular orbital study of associative sulfuryl group transfer, intramolecular migration, and pseudorotation Journal of Organic Chemistry. 61: 5986-5997.  0.072
1991 Davis JM, Cameron DR, Kubanek JM, Mizuyabu L, Thatcher GRJ. Acceleration of sulfate ester hydrolysis in hydrophobic environments Tetrahedron Letters. 32: 2205-2206. DOI: 10.1016/S0040-4039(00)79681-X  0.071
2002 Hom DB, Thatcher G, Tibesar R. Growth factor therapy to improve soft tissue healing Facial Plastic Surgery. 18: 41-52. PMID 11823932  0.069
1988 Hall BM, Tiller DJ, Hardie I, Mahoney J, Mathew T, Thatcher G, Miach P, Thomson N, Sheil AGR. Comparison of three immunosuppressive regimens in cadaver renal transplantation: Long-term cyclosporine, short-term cyclosporine followed by azathioprine and prednisolone, and azathioprine and prednisolone without cyclosporine New England Journal of Medicine. 318: 1499-1507. PMID 3285215  0.069
1996 Vaino AR, Chan SS, Szarek WA, Thatcher GR. An Experimental Reexamination of the Reverse Anomeric Effect in N-Glycosylimidazoles. The Journal of Organic Chemistry. 61: 4514-4515. PMID 11667373 DOI: 10.1021/Jo960652Z  0.068
1987 Hall BM, Sheil AG, Tiller DJ, Hardie I, Mahoney J, Thatcher G, Mathew T, Thompson N, Miach P. Australian multicentre trial in cadaver renal transplantation comparison of short- and long-term cyclosporine A therapy with conventional therapy Transplantation Proceedings. 19: 1833-1834. PMID 3079045  0.068
1996 Yoklavich MF, Thatcher GL, Sasken HF. Vessel healing response to bioabsorbable implant Transactions of the Annual Meeting of the Society For Biomaterials in Conjunction With the International Biomaterials Symposium. 1: 589.  0.065
1995 Pregel MJ, Dunn EJ, Nagelkerke R, Thatcher GRJ, Buncel E. Alkali-metal ion catalysis and inhibition in nucleophilic displacement reactions of phosphorus-, sulfur- and carbon-based esters Chemical Society Reviews. 24: 449-455.  0.065
2010 PREGEL MJ, DUNN EJ, NAGELKERKE R, THATCHER GRJ, BUNCEL E. ChemInform Abstract: Alkali-Metal Ion Catalysis and Inhibition in Nucleophilic Displacement Reactions of Phosphorus-, Sulfur- and Carbon-Based Esters Cheminform. 27: no-no. DOI: 10.1002/chin.199629313  0.065
1991 Krol ES, Davis JM, Thatcher GRJ. Hydrolysis of phosphonoformate esters: Product distribution and reactivity patterns Journal of the Chemical Society, Chemical Communications. 118-119. DOI: 10.1039/C39910000118  0.064
1996 Williams VE, Lemieux RP, Thatcher GRJ. Substituent effects on the stability of arene-arene complexes: An AM1 study of the conformational equilibria of cis-1,3-diphenylcyclohexanes Journal of Organic Chemistry. 61: 1927-1933. DOI: 10.1021/Jo951724+  0.062
2002 Imola MJ, Hamlar DD, Thatcher G, Chowdhury K. The versatility of distraction osteogenesis in craniofacial surgery Archives of Facial Plastic Surgery : Official Publication For the American Academy of Facial Plastic and Reconstructive Surgery, Inc. and the International Federation of Facial Plastic Surgery Societies. 4: 8-19. PMID 11843671  0.058
1999 McCracken PG, Ferguson CG, Vizitiu D, Walkinshaw CS, Wang Y, Thatcher GRJ. Amino-cyclodextrins as biomimetics: Catalysis of the Kemp elimination Journal of the Chemical Society. Perkin Transactions 2. 911-912.  0.057
1984 Taylor AF, Campsie IC, Dickinson FS, Thatcher G. DOUNREAY FAST REACTOR BOILERS GET A NEW LEASE OF LIFE. PART 3: DEVELOPMENT OF THE SLEEVING REPAIR TECHNIQUES Nuclear Engineering International. 29: 34-38.  0.054
1963 SAUNDERS SJ, THATCHER GN. PSYCHOSOMATIC ASPECTS OF MEDICINE South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde. 37: 1173. PMID 14074810  0.053
2015 Ziniel PD, Karumudi B, Barnard AH, Fisher EMS, Thatcher GRJ, Podust LM, Williams DL. The Schistosoma mansoni Cytochrome P450 (CYP3050A1) Is Essential for Worm Survival and Egg Development Plos Neglected Tropical Diseases. 9. DOI: 10.1371/journal.pntd.0004279  0.052
1996 Gorin BI, Riopelle RJ, Thatcher GRJ. Efficient perfacial derivatization of cyclodextrins at the primary face Tetrahedron Letters. 37: 4647-4650. DOI: 10.1016/0040-4039(96)00916-1  0.052
2016 Ziniel PD, Karumudi B, Barnard AH, Fisher EM, Thatcher GR, Podust LM, Williams DL. Correction: The Schistosoma mansoni Cytochrome P450 (CYP3050A1) Is Essential for Worm Survival and Egg Development. Plos Neglected Tropical Diseases. 10: e0004439. PMID 26828364 DOI: 10.1371/journal.pntd.0004439  0.051
2007 Marchand WR, Lee JN, Thatcher JW, Thatcher GW, Jensen C, Starr J. Motor deactivation in the human cortex and basal ganglia. Neuroimage. 38: 538-48. PMID 17888686 DOI: 10.1016/j.neuroimage.2007.07.036  0.05
2003 Buncel E, Nagelkerke R, Thatcher GRJ. Alkali metal ion catalysis in nucleophilic displacement by ethoxide ion on p-nitrophenyl phenylphosphonate: Evidence for multiple metal ion catalysis1 Canadian Journal of Chemistry. 81: 53-63. DOI: 10.1139/V02-202  0.048
1970 Eales L, Thatcher GN, Grosser Y, Levey M. Renal function and porphyrin metabolism following cardiac transplantation South African Medical Journal. 44: 322-328. PMID 4907759  0.048
1966 Krivit W, Brubaker C, Hartmann J, Murphy ML, Pierce M, Thatcher G. Induction of remission in acute leukemia ofchildhood by combination of prednisone and either 6-mercaptopurine or methotrexate The Journal of Pediatrics. 68: 965-968. PMID 5935078  0.043
1983 Thatcher G. Electromagnetic flowmeters .  0.042
2002 Preciado DA, Thatcher G, Panitch HB, Rimell FL. Transtracheal oxygen catheters in a pediatric population. The Annals of Otology, Rhinology, and Laryngology. 111: 310-4. PMID 11991581 DOI: 10.1177/000348940211100405  0.041
1995 Parnham AP, Flexman JP, Saker BM, Thatcher GN. Primary varicella in adult renal transplant recipients: A report of three cases plus a review of the literature Clinical Transplantation. 9: 115-118. PMID 7599399  0.04
1982 Sakar BM, Hurst PE, Thatcher GN. Urinary prostaglandin (PG) and thromboxane (TXA) metabolites in the detection of cadaveric renal transplant rejection Australian and New Zealand Journal of Medicine. 12: 333.  0.039
2007 Thatcher GRJ. Organic nitrates and nitrites as stores of NO bioactivity Radicals For Life: the Various Forms of Nitric Oxide. 347-380. DOI: 10.1016/B978-044452236-8/50017-4  0.038
2010 Thatcher G. The Supreme Court of New Zealand Commonwealth Law Bulletin. 36: 461-468. DOI: 10.1080/03050718.2010.500837  0.038
1996 Thatcher GRJ, Cameron DR. Influence of strain on hydrolysis of five-membered sulfate and phosphate esters Journal of the Chemical Society. Perkin Transactions 2. 5: 767-769.  0.037
1997 Ravsten DV, Smith NB, Thatcher GW. Spontaneous male orgasm in association with venlafaxine [2] American Family Physician. 55. PMID 9105188  0.035
1975 Thatcher G. Edelin case verdict sets off U.S. debate Christian Science Monitor (Boston, Mass. : Eastern Ed.). 2. PMID 11649033  0.035
1910 Nutt A, Gomme GL, Stenton FM, Wright AR, Freire Marreco B, Halliday WR, Thatcher G. Correspondence Folklore. 21: 379-388. DOI: 10.1080/0015587X.1910.9719949  0.035
1974 Goldin AR, Naude JH, Thatcher GN. Therapeutic percutaneous renal infarction British Journal of Urology. 46: 133-135. PMID 4596072  0.032
1976 Thatcher GN. Treatment of renal lupus erythematosus with high dose steroid and cyclophosphamide Kidney International. 9: 379.  0.032
1982 Duncombe E, Thatcher G. ELECTROMAGNETIC OUTLET TEMPERATURE REGULATOR FOR LMFBR BREEDER SUB-ASSEMBLIES Proceedings of the Annual Reliability and Maintainability Symposium. 1.  0.031
1996 Carruthers DM, Whishaw JM, Thomas MAB, Thatcher G. Planes, kangaroos, and the CAPD manual Peritoneal Dialysis International. 16. PMID 8728242  0.031
2009 Thatcher GL. Product realization: The processing of bioabsorbable polymers Degradable Polymers For Skeletal Implants. 93-121.  0.031
1974 Baker RC, Thatcher G. Some recent development in electromagnetic flowmeasurement .  0.03
1971 Ackermann JB, Thatcher GN, Uys CJ, Du Toit E, Myers B. Massive proteinuria after renal transplantation. A case report. South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie. 9: 99-104. PMID 4936963  0.03
1978 Thatcher G. RECENT DEVELOPMENTS IN LMFBR COOLANT FLOW MEASUREMENT TECHNIQUES . 193-120.  0.029
1990 Thomas M, Saker BM, Thatcher GN, Hurst PE, Moody H. Cost-effectiveness of weekly and fortnightly subcutaneous erythropoietin Lancet. 335: 1533-1534. PMID 1972467  0.029
1997 Borrajo AMP, Gal JF, Maria PC, Decouzon M, Ripley DC, Buncel E, Thatcher GRJ. Gas-Phase Cation Basicities for Sulfuryl Species from Calculation and Experiment Journal of Organic Chemistry. 62: 9203-9209.  0.028
1981 Davidson DF, Duncombe E, Thatcher G. SODIUM ELECTROTECHNOLOGY AT THE RISLEY NUCLEAR POWER DEVELOPMENT LABORATORIES Nuclear Energy. 20: 79-90.  0.028
1971 THATCHER G. ELECTROMAGNETIC FLOWMETERS FOR LIQUID METALS .  0.026
2003 Thatcher GW, Maisel RH. The long-term evaluation of tracheostomy in the management of severe obstructive sleep apnea Laryngoscope. 113: 201-204. PMID 12567068 DOI: 10.1097/00005537-200302000-00001  0.024
1972 Troup CW, Thatcher G, Hodgson NB. Infiltrative lesion of the bladder presenting as gross hematuria in child with leukemia: case report Journal of Urology. 107: 314-315. PMID 4501382  0.023
1966 Peart WS, Lubash GD, Thatcher GN, Muiesan G. Electrophoresis of pig and human renin Biochimica Et Biophysica Acta. 118: 640-643. PMID 5970866 DOI: 10.1016/S0926-6593(66)80105-4  0.023
2007 Thatcher JW, Marchand WR, Thatcher GW, Jacobs A, Jensen C. Clinical characteristics and health service use of veterans with comorbid bipolar disorder and PTSD. Psychiatric Services (Washington, D.C.). 58: 703-7. PMID 17463354 DOI: 10.1176/appi.ps.58.5.703  0.022
2008 Robbins JM, Thatcher GE, Webb DA, Valdmanis VG. Nutritionist visits, diabetes classes, and hospitalization rates and charges: the Urban Diabetes Study. Diabetes Care. 31: 655-60. PMID 18184894 DOI: 10.2337/dc07-1871  0.021
1980 Moulsdale M, Harper JM, Thatcher GN. Unusual mycobacterium infection in a renal transplant recipient Medical Journal of Australia. 2: 450-451. PMID 7010100  0.019
1975 Smith JD, Rabkin R, Stables D, Thatcher GN, Eales L. Analgesic renal papillary necrosis South African Medical Journal. 49: 1819-1822. PMID 1188544  0.018
1981 Mahoney DA, Barden AE, Vandongen R, Hurst P, Banks R, Beilin LJ, Saker B, Thatcher G. URINARY THROMBOXANE B2 IN ALLOGRAFT REJECTION The Lancet. 318: 1046. PMID 6118500 DOI: 10.1016/S0140-6736(81)91240-X  0.018
1971 Keeton GR, Rabkin R, Thatcher G, Eales L. BLOOD PRIMING FOR HÆMODIALYSIS The Lancet. 298: 311. PMID 4104993 DOI: 10.1016/S0140-6736(71)91351-1  0.016
1984 Thatcher G, Evans RA, Thomson A, Winstanley JP. MAGNETIC CURIE POINT AS A TEMPERATURE SENSING PARAMETER IN LMFBR TECHNOLOGY . 1: 433-438.  0.016
1973 Rabkin R, Thatcher GN, Diamond LH, Eales L. The nephrotic syndrome, malignancy and immunosuppression South African Medical Journal. 47: 605-606. PMID 4739810  0.014
1974 Davidson DF, Thatcher G. LIQUID SODIUM ELECTRO-TECHNOLOGY Pumps For Nucl Power Plant, Conv. 141-148.  0.013
1985 Thatcher G. Insulin injections: The case against random rotation American Journal of Nursing. 85: 690-692. PMID 3890543  0.01
1982 Ho SWC, Thatcher GN, Matz LR. Reversible renal failure due to renal cholesterol embolism Australian and New Zealand Journal of Medicine. 12: 531-533. PMID 6960876 DOI: 10.1111/j.1445-5994.1982.tb03839.x  0.01
1981 Moulsdale MT, Harper JM, Thatcher GN. Fungal peritonitis: complication of continuous ambulatory peritoneal dialysis Medical Journal of Australia. 1: 88. PMID 7231259  0.01
1980 Saueracker GC, Dawkins RL, Hurst P, Saker BM, Thatcher G, Haywood EF. Elective transfusion or HLA matching. Transplantation. 30: 394-5. PMID 7006173  0.01
1973 Stables DP, Thatcher GN. Traumatic renal vein thrombosis associated with renal artery occlusion British Journal of Radiology. 46: 64-66. PMID 4683332  0.01
1973 Thatcher GN. Infections in renal failure South African Medical Journal. 47: 427-432. PMID 4486962  0.01
1972 Quantock OP, Thatcher GN. Reversible Renal Failure with Renal Artery Occlusion British Medical Journal. 2: 27-28. PMID 4536923 DOI: 10.1136/bmj.2.5804.27  0.01
1965 Peart WS, Lloyd AM, Thatcher GN, Payne N, Stone N, Lever AF. Purification of pig renin Biochemical Journal. 96. PMID 4955597 DOI: 10.1042/bj0960031c  0.01
1963 SAUNDERS SJ, THATCHER GN. THE RETINOPATHIES South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde. 37: 1174-1175. PMID 14074811  0.01
1963 SAUNDERS SJ, THATCHER GN. TOXOPLASMOSIS IN THE ADULT South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde. 37: 1026-1029. PMID 14074809  0.01
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