Tim Townes - Publications

Affiliations: 
Biochemistry and Molecular Genetics University of Alabama, Birmingham, Birmingham, AL, United States 
Area:
Molecular Biology, Genetics

102 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Sun CW, Wu LC, Wankhede M, Wang D, Thoerner J, Woody L, Sorg BS, Townes TM, Terman DS. Exogenous sickle erythrocytes combined with vascular disruption trigger disseminated tumor vaso-occlusion and lung tumor regression. Jci Insight. 4. PMID 30944254 DOI: 10.1172/jci.insight.125535  0.48
2019 Sun CW, Yang J, Kleschyov A, Zhuge Z, Carlstrom M, Pernow J, Wajih N, Isbell TS, Oh JY, Cabrales P, Tsai A, Townes T, Kim-Shapiro DB, Patel RP, Lundberg JO. Hemoglobin β93 Cysteine is Not Required for Export of Nitric Oxide Bioactivity From the Red Blood Cell. Circulation. PMID 30905171 DOI: 10.1161/CIRCULATIONAHA.118.039284  0.48
2018 Mattapally S, Pawlik KM, Fast VG, Zumaquero E, Lund FE, Randall TD, Townes TM, Zhang J. Human Leukocyte Antigen Class I and II Knockout Human Induced Pluripotent Stem Cell-Derived Cells: Universal Donor for Cell Therapy. Journal of the American Heart Association. 7: e010239. PMID 30488760 DOI: 10.1161/JAHA.118.010239  0.36
2018 Su H, Sun CW, Liu SM, He X, Hu H, Pawlik KM, Townes TM, Han X, Klug CA, Henary M, Chen Y, Li L, Zheng YG, Zhao X. Defining the epigenetic status of blood cells using a cyanine-based fluorescent probe for PRMT1. Blood Advances. 2: 2829-2836. PMID 30373889 DOI: 10.1182/bloodadvances.2018020727  0.48
2018 Devadasan D, Sun CW, Westin ER, Wu LC, Pawlik KM, Townes TM, Goldman FD. Bmt Following Non-Myeloablative Treosulfan Conditioning is Curative in a Murine Model of Sickle Cell Disease. Biology of Blood and Marrow Transplantation : Journal of the American Society For Blood and Marrow Transplantation. PMID 29684562 DOI: 10.1016/j.bbmt.2018.04.011  0.48
2017 Liu Z, Zhang C, Skamagki M, Khodadadi-Jamayran A, Zhang W, Kong D, Chang CW, Feng J, Han X, Townes TM, Li H, Kim K, Zhao R. Elevated p53 Activities Restrict Differentiation Potential of MicroRNA-Deficient Pluripotent Stem Cells. Stem Cell Reports. 9: 1604-1617. PMID 29141234 DOI: 10.1016/j.stemcr.2017.10.006  0.36
2017 Sun CW, Wu LC, Knopick PL, Bradley DS, Townes T, Terman DS. Sickle Cells Produce Functional Immune Modulators and Cytotoxics. American Journal of Hematology. PMID 28646491 DOI: 10.1002/ajh.24836  0.48
2017 Giordano S, Zhao X, Chen YF, Litovsky SH, Hage FG, Townes TM, Sun CW, Wu LC, Oparil S, Xing D. Induced Pluripotent Stem Cell-Derived Endothelial Cells Overexpressing Interleukin-8 Receptors A/B and/or C-C Chemokine Receptors 2/5 Inhibit Vascular Injury Response. Stem Cells Translational Medicine. PMID 28233474 DOI: 10.1002/sctm.16-0316  0.48
2016 Li C, Ding L, Sun CW, Wu LC, Zhou D, Pawlik KM, Khodadadi-Jamayran A, Westin E, Goldman FD, Townes TM. Novel HDAd/EBV Reprogramming Vector and Highly Efficient Ad/CRISPR-Cas Sickle Cell Disease Gene Correction. Scientific Reports. 6: 30422. PMID 27460639 DOI: 10.1038/srep30422  1
2016 Sun CW, Willmon C, Wu LC, Knopick P, Thoerner J, Vile R, Townes TM, Terman DS. Sickle Cells Abolish Melanoma Tumorigenesis in Hemoglobin SS Knockin Mice and Augment the Tumoricidal Effect of Oncolytic Virus In Vivo. Frontiers in Oncology. 6: 166. PMID 27458571 DOI: 10.3389/fonc.2016.00166  1
2016 Tran NT, Su H, Khodadadi-Jamayran A, Lin S, Zhang L, Zhou D, Pawlik KM, Townes TM, Chen Y, Mulloy JC, Zhao X. The AS-RBM15 lncRNA enhances RBM15 protein translation during megakaryocyte differentiation. Embo Reports. PMID 27118388 DOI: 10.15252/embr.201541970  1
2016 Shao Z, Zhang R, Khodadadi-Jamayran A, Chen B, Crowley MR, Festok MA, Crossman DK, Townes TM, Hu K. The acetyllysine reader BRD3R promotes human nuclear reprogramming and regulates mitosis. Nature Communications. 7: 10869. PMID 26947130 DOI: 10.1038/ncomms10869  1
2016 Kang L, Yao C, Khodadadi-Jamayran A, Xu W, Zhang R, Banerjee NS, Chang CW, Chow LT, Townes T, Hu K. The universal 3D3 antibody of human PODXL is pluripotent cytotoxic, and identifies a residual population after extended differentiation of pluripotent stem cells. Stem Cells and Development. PMID 26886504 DOI: 10.1089/scd.2015.0321  1
2015 Gu Y, Jones AE, Yang W, Liu S, Dai Q, Liu Y, Swindle CS, Zhou D, Zhang Z, Ryan TM, Townes TM, Klug CA, Chen D, Wang H. The histone H2A deubiquitinase Usp16 regulates hematopoiesis and hematopoietic stem cell function. Proceedings of the National Academy of Sciences of the United States of America. PMID 26699484 DOI: 10.1073/pnas.1517041113  1
2015 Zhang L, Tung NT, Su H, Wang R, Lu Y, Tang H, Aoyagi S, Guo A, Khodadadi-Jamayran A, Zhou D, Qian K, Hricik T, Côté J, Han X, Zhou W, ... ... Townes T, et al. Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing. Elife. 4. PMID 26575292 DOI: 10.7554/eLife.07938  0.32
2015 Chang CW, Lai YS, Westin E, Khodadadi-Jamayran A, Pawlik KM, Lamb LS, Goldman FD, Townes TM. Modeling Human Severe Combined Immunodeficiency and Correction by CRISPR/Cas9-Enhanced Gene Targeting. Cell Reports. 12: 1668-77. PMID 26321643 DOI: 10.1016/j.celrep.2015.08.013  1
2015 Harper VM, Oh JY, Stapley R, Marques MB, Wilson L, Barnes S, Sun CW, Townes T, Patel RP. Peroxiredoxin-2 recycling is inhibited during erythrocyte storage. Antioxidants & Redox Signaling. 22: 294-307. PMID 25264713 DOI: 10.1089/ars.2014.5950  1
2015 Zhang L, Tran NT, Su H, Wang R, Lu Y, Tang H, Aoyagi S, Guo A, Khodadadi-Jamayran A, Zhou D, Qian K, Hricik T, Côté J, Han X, Zhou W, ... ... Townes T, et al. Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing Elife. 4.  1
2014 Yang Z, Augustin J, Chang C, Hu J, Shah K, Chang CW, Townes T, Jiang H. The DPY30 subunit in SET1/MLL complexes regulates the proliferation and differentiation of hematopoietic progenitor cells. Blood. 124: 2025-33. PMID 25139354 DOI: 10.1182/blood-2014-01-549220  1
2014 Chang CW, Lai YS, Lamb LS, Townes TM. Broad T-cell receptor repertoire in T-lymphocytes derived from human induced pluripotent stem cells. Plos One. 9: e97335. PMID 24828440 DOI: 10.1371/journal.pone.0097335  1
2014 Yang W, Lee YH, Jones AE, Woolnough JL, Zhou D, Dai Q, Wu Q, Giles KE, Townes TM, Wang H. The histone H2A deubiquitinase Usp16 regulates embryonic stem cell gene expression and lineage commitment. Nature Communications. 5: 3818. PMID 24784029 DOI: 10.1038/ncomms4818  1
2013 Zhang Z, Jones A, Joo HY, Zhou D, Cao Y, Chen S, Erdjument-Bromage H, Renfrow M, He H, Tempst P, Townes TM, Giles KE, Ma L, Wang H. USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing. Genes & Development. 27: 1581-95. PMID 23824326 DOI: 10.1101/gad.211037.112  1
2013 Liu Y, Sun CW, Honavar J, Townes T, Patel RP. Role of the b93cys, ATP and adenosine in red cell dependent hypoxic vasorelaxation. International Journal of Physiology, Pathophysiology and Pharmacology. 5: 21-31. PMID 23525514  1
2013 Vinchi F, De Franceschi L, Ghigo A, Townes T, Cimino J, Silengo L, Hirsch E, Altruda F, Tolosano E. Hemopexin therapy improves cardiovascular function by preventing heme-induced endothelial toxicity in mouse models of hemolytic diseases. Circulation. 127: 1317-29. PMID 23446829 DOI: 10.1161/CIRCULATIONAHA.112.130179  1
2013 Vitturi DA, Sun CW, Harper VM, Thrash-Williams B, Cantu-Medellin N, Chacko BK, Peng N, Dai Y, Wyss JM, Townes T, Patel RP. Antioxidant functions for the hemoglobin β93 cysteine residue in erythrocytes and in the vascular compartment in vivo. Free Radical Biology & Medicine. 55: 119-29. PMID 23159546 DOI: 10.1016/j.freeradbiomed.2012.11.003  1
2012 Chen Y, Wang JJ, Li J, Hosoya KI, Ratan R, Townes T, Zhang SX. Activating transcription factor 4 mediates hyperglycaemia-induced endothelial inflammation and retinal vascular leakage through activation of STAT3 in a mouse model of type 1 diabetes. Diabetologia. 55: 2533-45. PMID 22660795 DOI: 10.1007/s00125-012-2594-1  1
2012 Young MA, Larson DE, Sun CW, George DR, Ding L, Miller CA, Lin L, Pawlik KM, Chen K, Fan X, Schmidt H, Kalicki-Veizer J, Cook LL, Swift GW, Demeter RT, ... ... Townes TM, et al. Background mutations in parental cells account for most of the genetic heterogeneity of induced pluripotent stem cells. Cell Stem Cell. 10: 570-82. PMID 22542160 DOI: 10.1016/j.stem.2012.03.002  1
2012 Suragani RN, Zachariah RS, Velazquez JG, Liu S, Sun CW, Townes TM, Chen JJ. Heme-regulated eIF2α kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis. Blood. 119: 5276-84. PMID 22498744 DOI: 10.1182/blood-2011-10-388132  1
2012 Lai YS, Chang CW, Pawlik KM, Zhou D, Renfrow MB, Townes TM. SRY (sex determining region Y)-box2 (Sox2)/poly ADP-ribose polymerase 1 (Parp1) complexes regulate pluripotency. Proceedings of the National Academy of Sciences of the United States of America. 109: 3772-7. PMID 22362888 DOI: 10.1073/pnas.1108595109  1
2011 Zhang Z, Jones A, Sun CW, Li C, Chang CW, Joo HY, Dai Q, Mysliwiec MR, Wu LC, Guo Y, Yang W, Liu K, Pawlik KM, Erdjument-Bromage H, Tempst P, ... ... Townes TM, et al. PRC2 complexes with JARID2, MTF2, and esPRC2p48 in ES cells to modulate ES cell pluripotency and somatic cell reprogramming. Stem Cells (Dayton, Ohio). 29: 229-40. PMID 21732481 DOI: 10.1002/stem.578  1
2011 Lin WJ, Zheng X, Lin CC, Tsao J, Zhu X, Cody JJ, Coleman JM, Gherzi R, Luo M, Townes TM, Parker JN, Chen CY. Posttranscriptional control of type I interferon genes by KSRP in the innate immune response against viral infection. Molecular and Cellular Biology. 31: 3196-207. PMID 21690298 DOI: 10.1128/MCB.05073-11  1
2011 Liang Q, Deng H, Sun CW, Townes TM, Zhu F. Negative regulation of IRF7 activation by activating transcription factor 4 suggests a cross-regulation between the IFN responses and the cellular integrated stress responses. Journal of Immunology (Baltimore, Md. : 1950). 186: 1001-10. PMID 21148039 DOI: 10.4049/jimmunol.1002240  1
2010 Zhou D, Liu K, Sun CW, Pawlik KM, Townes TM. KLF1 regulates BCL11A expression and gamma- to beta-globin gene switching. Nature Genetics. 42: 742-4. PMID 20676097 DOI: 10.1038/ng.637  1
2009 Seo J, Fortuno ES, Suh JM, Stenesen D, Tang W, Parks EJ, Adams CM, Townes T, Graff JM. Atf4 regulates obesity, glucose homeostasis, and energy expenditure. Diabetes. 58: 2565-73. PMID 19690063 DOI: 10.2337/db09-0335  1
2009 Chang CW, Lai YS, Pawlik KM, Liu K, Sun CW, Li C, Schoeb TR, Townes TM. Polycistronic lentiviral vector for "hit and run" reprogramming of adult skin fibroblasts to induced pluripotent stem cells. Stem Cells (Dayton, Ohio). 27: 1042-9. PMID 19415770 DOI: 10.1002/stem.39  1
2008 Townes TM. Gene replacement therapy for sickle cell disease and other blood disorders. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 193-6. PMID 19074080 DOI: 10.1182/asheducation-2008.1.193  1
2008 Hiratani I, Ryba T, Itoh M, Yokochi T, Schwaiger M, Chang CW, Lyou Y, Townes TM, Schübeler D, Gilbert DM. Global reorganization of replication domains during embryonic stem cell differentiation. Plos Biology. 6: e245. PMID 18842067 DOI: 10.1371/journal.pbio.0060245  1
2008 Isbell TS, Sun CW, Wu LC, Teng X, Vitturi DA, Branch BG, Kevil CG, Peng N, Wyss JM, Ambalavanan N, Schwiebert L, Ren J, Pawlik KM, Renfrow MB, Patel RP, ... Townes TM, et al. SNO-hemoglobin is not essential for red blood cell-dependent hypoxic vasodilation. Nature Medicine. 14: 773-7. PMID 18516054 DOI: 10.1038/nm1771  1
2008 Lange PS, Chavez JC, Pinto JT, Coppola G, Sun CW, Townes TM, Geschwind DH, Ratan RR. ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivo. The Journal of Experimental Medicine. 205: 1227-42. PMID 18458112 DOI: 10.1084/jem.20071460  1
2008 Patel R, Townes T. SNO-hemoglobin and hypoxic vasodilation Nature Medicine. 14: 1009-1010. DOI: 10.1038/nm1008-1009b  1
2007 Hanna J, Wernig M, Markoulaki S, Sun CW, Meissner A, Cassady JP, Beard C, Brambrink T, Wu LC, Townes TM, Jaenisch R. Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science (New York, N.Y.). 318: 1920-3. PMID 18063756 DOI: 10.1126/science.1152092  1
2006 Pilon AM, Nilson DG, Zhou D, Sangerman J, Townes TM, Bodine DM, Gallagher PG. Alterations in expression and chromatin configuration of the alpha hemoglobin-stabilizing protein gene in erythroid Kruppel-like factor-deficient mice. Molecular and Cellular Biology. 26: 4368-77. PMID 16705186 DOI: 10.1128/MCB.02216-05  1
2006 Wu LC, Sun CW, Ryan TM, Pawlik KM, Ren J, Townes TM. Correction of sickle cell disease by homologous recombination in embryonic stem cells. Blood. 108: 1183-8. PMID 16638928 DOI: 10.1182/blood-2006-02-004812  1
2006 Zhou D, Pawlik KM, Ren J, Sun CW, Townes TM. Differential binding of erythroid Krupple-like factor to embryonic/fetal globin gene promoters during development. The Journal of Biological Chemistry. 281: 16052-7. PMID 16606611 DOI: 10.1074/jbc.M601182200  1
2005 Foster KW, Liu Z, Nail CD, Li X, Fitzgerald TJ, Bailey SK, Frost AR, Louro ID, Townes TM, Paterson AJ, Kudlow JE, Lobo-Ruppert SM, Ruppert JM. Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasia. Oncogene. 24: 1491-500. PMID 15674344 DOI: 10.1038/sj.onc.1208307  1
2004 Hong JS, Waud WR, Levasseur DN, Townes TM, Wen H, McPherson SA, Moore BA, Bebok Z, Allan PW, Secrist JA, Parker WB, Sorscher EJ. Excellent in vivo bystander activity of fludarabine phosphate against human glioma xenografts that express the escherichia coli purine nucleoside phosphorylase gene. Cancer Research. 64: 6610-5. PMID 15374975 DOI: 10.1158/0008-5472.CAN-04-0012  1
2004 Zhou D, Ren JX, Ryan TM, Higgins NP, Townes TM. Rapid tagging of endogenous mouse genes by recombineering and ES cell complementation of tetraploid blastocysts. Nucleic Acids Research. 32: e128. PMID 15356288 DOI: 10.1093/nar/gnh128  1
2004 Yang X, Matsuda K, Bialek P, Jacquot S, Masuoka HC, Schinke T, Li L, Brancorsini S, Sassone-Corsi P, Townes TM, Hanauer A, Karsenty G. ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome. Cell. 117: 387-98. PMID 15109498 DOI: 10.1016/S0092-8674(04)00344-7  1
2004 Levasseur DN, Ryan TM, Reilly MP, McCune SL, Asakura T, Townes TM. A recombinant human hemoglobin with anti-sickling properties greater than fetal hemoglobin. The Journal of Biological Chemistry. 279: 27518-24. PMID 15084588 DOI: 10.1074/jbc.M402578200  1
2004 Roybal CN, Yang S, Sun CW, Hurtado D, Vander Jagt DL, Townes TM, Abcouwer SF. Homocysteine increases the expression of vascular endothelial growth factor by a mechanism involving endoplasmic reticulum stress and transcription factor ATF4. The Journal of Biological Chemistry. 279: 14844-52. PMID 14747470 DOI: 10.1074/jbc.M312948200  1
2003 Bennett EM, Anand R, Allan PW, Hassan AE, Hong JS, Levasseur DN, McPherson DT, Parker WB, Secrist JA, Sorscher EJ, Townes TM, Waud WR, Ealick SE. Designer gene therapy using an Escherichia coli purine nucleoside phosphorylase/prodrug system. Chemistry & Biology. 10: 1173-81. PMID 14700625 DOI: 10.1016/j.chembiol.2003.11.008  1
2003 Levasseur DN, Ryan TM, Pawlik KM, Townes TM. Correction of a mouse model of sickle cell disease: lentiviral/antisickling beta-globin gene transduction of unmobilized, purified hematopoietic stem cells. Blood. 102: 4312-9. PMID 12933581 DOI: 10.1182/blood-2003-04-1251  1
2003 Aslan M, Ryan TM, Townes TM, Coward L, Kirk MC, Barnes S, Alexander CB, Rosenfeld SS, Freeman BA. Nitric oxide-dependent generation of reactive species in sickle cell disease. Actin tyrosine induces defective cytoskeletal polymerization. The Journal of Biological Chemistry. 278: 4194-204. PMID 12401783 DOI: 10.1074/jbc.M208916200  1
2003 Heck S, Ermakova O, Iwasaki H, Akashi K, Sun CW, Ryan TM, Townes T, Graf T. Distinguishable live erythroid and myeloid cells in beta-globin ECFP x lysozyme EGFP mice. Blood. 101: 903-6. PMID 12393544 DOI: 10.1182/blood-2002-06-1861  1
2002 Bradley MB, Sattler RM, Raftopoulos H, Ward M, Grossman IR, Townes TM, Ryan TA, Bank A. Correction of phenotype in a thalassemia mouse model using a nonmyeloablative marrow transplantation regimen. Biology of Blood and Marrow Transplantation : Journal of the American Society For Blood and Marrow Transplantation. 8: 453-61. PMID 12234171  1
2002 Pandya K, Townes TM. Basic residues within the Kruppel zinc finger DNA binding domains are the critical nuclear localization determinants of EKLF/KLF-1. The Journal of Biological Chemistry. 277: 16304-12. PMID 11844803 DOI: 10.1074/jbc.M200866200  1
2002 Masuoka HC, Townes TM. Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice. Blood. 99: 736-45. PMID 11806972 DOI: 10.1182/blood.V99.3.736  1
2001 Aslan M, Ryan TM, Adler B, Townes TM, Parks DA, Thompson JA, Tousson A, Gladwin MT, Patel RP, Tarpey MM, Batinic-Haberle I, White CR, Freeman BA. Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease. Proceedings of the National Academy of Sciences of the United States of America. 98: 15215-20. PMID 11752464 DOI: 10.1073/pnas.221292098  1
2001 Divoky V, Liu Z, Ryan TM, Prchal JF, Townes TM, Prchal JT. Mouse model of congenital polycythemia: Homologous replacement of murine gene by mutant human erythropoietin receptor gene Proceedings of the National Academy of Sciences of the United States of America. 98: 986-991. PMID 11158582 DOI: 10.1073/pnas.98.3.986  1
2001 Pandya K, Donze D, Townes TM. Novel transactivation domain in erythroid Kruppel-like factor (EKLF). The Journal of Biological Chemistry. 276: 8239-43. PMID 11092887 DOI: 10.1074/jbc.M008457200  1
2000 Chen W, Wu X, Levasseur DN, Liu H, Lai L, Kappes JC, Townes TM. Lentiviral vector transduction of hematopoietic stem cells that mediate long-term reconstitution of lethally irradiated mice Stem Cells. 18: 352-359. PMID 11007919  1
2000 Ryan TM, Sun CW, Ren J, Townes TM. Human γ-globin gene promoter element regulates human β-globin gene developmental specificity Nucleic Acids Research. 28: 2736-2740. PMID 10908330  1
2000 Chen WY, Townes TM. Molecular mechanism for silencing virally transduced genes involves histone deacetylation and chromatin condensation Proceedings of the National Academy of Sciences of the United States of America. 97: 377-382. PMID 10618426 DOI: 10.1073/pnas.97.1.377  1
2000 Pandya KR, Townes TM. Multiple transacnvation domains of erythroid kruppel-like factor (eklf) Blood. 96.  1
2000 Ryan TM, Pawlik KM, Townes TM. Generation of novel embryonic stem cell lines from knockout-transgenic sickle cell disease mice: a new tool for therapeutic intervention Blood. 96.  1
1999 Zhao W, Noya F, Chen WY, Townes TM, Chow LT, Broker TR. Trichostatin A up-regulates human papillomavirus type 11 upstream regulatory region-E6 promoter activity in undifferentiated primary human keratinocytes. Journal of Virology. 73: 5026-33. PMID 10233965  1
1998 Graubert TA, Hug BA, Wesselschmidt R, Hsieh CL, Ryan TM, Townes TM, Ley TJ. Stochastic, stage-specific mechanisms account for the variegation of a human globin transgene Nucleic Acids Research. 26: 2849-2858. PMID 9611227 DOI: 10.1093/nar/26.12.2849  1
1998 Ryan TM, Ciayatta D, Townes TM. Knockout-transgenic mouse models of human hemoglobinopathies Experimental Hematology. 26: 807.  1
1998 Divoky V, Ryan T, Townes TM, Prchal JT. double-replacement gene targeting in mouse embryonic stem cells - creation of a mouse model for congenital polycythemia Experimental Hematology. 26: 765.  1
1997 Ryan TM, Ciavatta DJ, Townes TM. Knockout-transgenic mouse model of sickle cell disease Science. 278: 873-876. PMID 9346487 DOI: 10.1126/science.278.5339.873  1
1997 Chen WY, Bailey EC, McCune SL, Dong JY, Townes TM. Reactivation of silenced, virally transduced genes by inhibitors of histone deacetylase Proceedings of the National Academy of Sciences of the United States of America. 94: 5798-5803. PMID 9159154 DOI: 10.1073/pnas.94.11.5798  1
1997 Farmer SC, Sun CW, Winnier GE, Hogan BL, Townes TM. The bZIP transcription factor LCR-F1 is essential for mesoderm formation in mouse development. Genes & Development. 11: 786-98. PMID 9087432  1
1996 Lubovy M, McCune S, Dong JY, Prchal JF, Townes TM, Prchal JT. Stable transduction of recombinant adeno-associated virus into hematopoietic stem cells from normal and sickle cell patients Biology of Blood and Marrow Transplantation : Journal of the American Society For Blood and Marrow Transplantation. 2: 24-30. PMID 9078351  1
1996 Donze D, Jeancake PH, Townes TM. Activation of δ-globin gene expression by erythroid Krupple-like factor: A potential approach for gene therapy of sickle cell disease Blood. 88: 4051-4057. PMID 8916973  1
1995 Pawlik KM, Sun CW, Higgins NP, Townes TM. End joining of genomic DNA and transgene DNA in fertilized mouse eggs. Gene. 165: 173-81. PMID 8522172 DOI: 10.1016/0378-1119(95)00519-C  1
1995 Donze D, Townes TM, Bieker JJ. Role of erythroid Kruppel-like factor in human γ- to β-globin gene switching Journal of Biological Chemistry. 270: 1955-1959. PMID 7829533 DOI: 10.1074/jbc.270.4.1955  1
1995 Pawlik KM, Townes TM. Autonomous, erythroid-specific DNAse I hypersensitive site formed by human β-globin locus control region (LCR) 5' HS 2 in transgenic mice Developmental Biology. 169: 728-732. PMID 7781911 DOI: 10.1006/dbio.1995.1182  1
1995 Ciavatta DJ, Ryan TM, Farmer SC, Townes TM. Mouse model of human β0 thalassemia: Targeted deletion of the mouse βmaj- and βmin-glonbin genes in embryonic stem cells Proceedings of the National Academy of Sciences of the United States of America. 92: 9259-9263. PMID 7568113  1
1994 Caterina JJ, Ciavatta DJ, Donze D, Behringer RR, Townes TM. Multiple elements in human β-globin locus control region 5′ HS 2 are involved in enhancer activity and position independent, transgene expression Nucleic Acids Research. 22: 1006-1011. PMID 8152905 DOI: 10.1093/nar/22.6.1006  1
1994 Reilly MP, McCune SL, Ryan TM, Townes TM, Katsumata M, Asakura T. Preparation of recombinant hemoglobin in transgenic mice Methods in Enzymology. 231: 403-434. PMID 8041266 DOI: 10.1016/0076-6879(94)31028-9  1
1994 Caterina JJ, Donze D, Sun Cw, Ciavatta DJ, Townes TM. Cloning and functional characterization of LCR-F1: A bZIP transcription factor that activates erythroid-specific, human globin gene expression Nucleic Acids Research. 22: 2383-2391. PMID 8036168 DOI: 10.1093/nar/22.12.2383  1
1994 Mccune SL, Townes TM. Retroviral vector sequences inhibit human β-globin gene expression in transgenic mice Nucleic Acids Research. 22: 4477-4481. PMID 7971278 DOI: 10.1093/nar/22.21.4477  1
1994 Mccune SL, Reilly MP, Chomo MJ, Asakura T, Townes TM. Recombinant human hemoglobins designed for gene therapy of sickle cell disease Proceedings of the National Academy of Sciences of the United States of America. 91: 9852-9856. PMID 7937904 DOI: 10.1073/pnas.91.21.9852  1
1991 Caterina JJ, Ryan TM, Pawlik KM, Palmiter RD, Brinster RL, Behringer RR, Townes TM. Human beta-globin locus control region: analysis of the 5' DNase I hypersensitive site HS 2 in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 88: 1626-30. PMID 2000371  1
1991 Hayat M, Joyce CP, Townes TM, Chen TT, Powers DA, Dunham RA. Survival and integration rate of channel catfish and common carp embryos microinjected with DNA at various developmental stages Aquaculture. 99: 249-255. DOI: 10.1016/0044-8486(91)90245-3  1
1990 Townes TM, Behringer RR. Human globin locus activation region (LAR): role in temporal control Trends in Genetics. 6: 219-222. PMID 2202110 DOI: 10.1016/0168-9525(90)90182-6  1
1990 Ryan TM, Townes TM, Reilly MP, Asakura T, Palmiter RD, Brinster RL, Behringer RR. Human sickle hemoglobin in transgenic mice. Science (New York, N.Y.). 247: 566-8. PMID 2154033  1
1990 Behringer RR, Ryan TM, Palmiter RD, Brinster RL, Townes TM. Human gamma- to beta-globin gene switching in transgenic mice. Genes & Development. 4: 380-9. PMID 1692558  1
1989 Ryan TM, Behringer RR, Townes TM, Palmiter RD, Brinster RL. High-level erythroid expression of human α-globin genes in transgenic mice Proceedings of the National Academy of Sciences of the United States of America. 86: 37-41. PMID 2911581  1
1989 Behringer RR, Ryan TM, Reilly MP, Asakura T, Palmiter RD, Brinster RL, Townes TM. Synthesis of functional human hemoglobin in transgenic mice. Science (New York, N.Y.). 245: 971-3. PMID 2772649  1
1989 Ryan TM, Behringer RR, Martin NC, Townes TM, Palmiter RD, Brinster RL. A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice Genes &Amp; Development. 3: 314-323. PMID 2721958  1
1989 Townes TM, Ryan TM, Behringer RR, Palmiter RD, Brinster RL. DNase I super-hypersensitive sites direct high level erythroid expression of human alpha-, beta- and beta s- globin genes in transgenic mice Progress in Clinical and Biological Research. 316: 47-61. PMID 2594817  1
1987 Behringer RR, Hammer RE, Brinster RL, Palmiter RD, Townes TM. Two 3' sequences direct adult erythroid-specific expression of human β-globulin genes in transgenic mice Proceedings of the National Academy of Sciences of the United States of America. 84: 7056-7060. PMID 3478680  1
1987 Townes TM, Behringer RR, Hammer RE, Brinster RL, Palmiter RD. Multiple sequences regulate human beta-globin gene expression in transgenic mice Progress in Clinical and Biological Research. 251: 323-343. PMID 3432271  1
1987 Dunham RA, Eash J, Askins J, Townes TM. Transfer of the metallothionein-human growth hormone fusion gene into channel catfish Transactions of the American Fisheries Society. 116: 87-91. DOI: 10.1577/1548-8659(1987)116[87:TOTMGH]2.0.CO;2  1
1985 Lingrel JB, Townes TM, Shapiro SG, Wernke SM, Liberator PA, Menon AG. Structural organization of the alpha and beta globin loci of the goat Progress in Clinical and Biological Research. 191: 67-79. PMID 3901040  1
1985 Townes TM, Chen HY, Lingrel JB, Palmiter RD, Brinster RL. Expression of human β-globin genes in transgenic mice: effects of a flanking metallothionein-human growth hormone fusion gene Molecular and Cellular Biology. 5: 1977-1983. PMID 3018541  1
1985 Townes TM, Lingrel JB, Chen HY, Brinster RL, Palmiter RD. Erythroid-specific expression of human beta-globin genes in transgenic mice Embo Journal. 4: 1715-1723. PMID 2992937  1
1984 Townes TM, Shapiro SG, Wernke SM, Lingrel JB. Duplication of a new four-gene set during the evolution of the goat β-globin locus produced genes now expressed differentially in development Journal of Biological Chemistry. 259: 1896-1900. PMID 6693438  1
1984 Townes TM, Fitzgerald MC, Lingrel JB. Triplication of a four-gene set during evolution of the goat beta-globin locus produced three genes now expressed differentially during development. Proceedings of the National Academy of Sciences of the United States of America. 81: 6589-93. PMID 6593719  1
1983 Lingrel JB, Townes TM, Shapiro SG, Spence SE, Liberator PA, Wernke SM. Organization, structure, and expression of the goat globin genes Progress in Clinical and Biological Research. 134: 131-139. PMID 6320214  1
1983 Shapiro SG, Schon EA, Townes TM, Lingrel JB. Sequence and linkage of the goat εI and εII β-globin genes Journal of Molecular Biology. 169: 31-52. PMID 6312053 DOI: 10.1016/S0022-2836(83)80174-0  1
Show low-probability matches.