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Shehzad Z. Sheikh, Ph.D. - Publications

Affiliations: 
2010 Microbiology & Immunology University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Immunology, Microbiology Biology
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50 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Cheng MI, Hong L, Chen B, Chin S, Luthers CR, Bustillos C, Sheikh SZ, Su MA. Hypoxia-sensing by the Histone Demethylase UTX ( ) Controls Colitogenic CD4 T cell Fate and Mucosal Inflammation. Biorxiv : the Preprint Server For Biology. PMID 37546969 DOI: 10.1101/2023.07.27.550746  0.308
2022 Steinbach EC, Smeekens JM, Roy S, Toyonaga T, Cornaby C, Perini LB, Berglind AE, Kulis MD, Kim EH, Ferris MT, Furey TS, Burks AW, Sheikh SZ. Intestinal epithelial cell barrier dysfunction and elevated Angiopoietin-like 4 identified in orally susceptible peanut allergy model. Clinical and Experimental Allergy : Journal of the British Society For Allergy and Clinical Immunology. PMID 36336910 DOI: 10.1111/cea.14248  0.719
2022 Hoffner O'Connor M, Berglind A, Kennedy Ng MM, Keith BP, Lynch ZJ, Schaner MR, Steinbach EC, Herzog J, Trad OK, Jeck WR, Arthur JC, Simon JM, Sartor RB, Furey TS, Sheikh SZ. BET Protein Inhibition Regulates Macrophage Chromatin Accessibility and Microbiota-Dependent Colitis. Frontiers in Immunology. 13: 856966. PMID 35401533 DOI: 10.3389/fimmu.2022.856966  0.758
2022 Kanke M, Kennedy Ng MM, Connelly S, Singh M, Schaner M, Shanahan MT, Wolber EA, Beasley C, Lian G, Jain A, Long MD, Barnes EL, Herfarth HH, Isaacs KL, Hansen JJ, ... ... Sheikh SZ, et al. Single-cell analysis reveals unexpected cellular changes and transposon expression signatures in the colonic epithelium of treatment-naïve adult Crohn's disease patients. Cellular and Molecular Gastroenterology and Hepatology. PMID 35158099 DOI: 10.1016/j.jcmgh.2022.02.005  0.303
2021 Toyonaga T, Araba KC, Kennedy MM, Keith BP, Wolber EA, Beasley C, Steinbach EC, Schaner MR, Jain A, Long MD, Barnes EL, Herfarth HH, Isaacs KL, Hansen JJ, Kapadia MR, ... ... Sheikh SZ, et al. Increased colonic expression of ACE2 associates with poor prognosis in Crohn's disease. Scientific Reports. 11: 13533. PMID 34188154 DOI: 10.1038/s41598-021-92979-2  0.722
2021 Kosinsky RL, Zerche M, Kutschat AP, Nair A, Ye Z, Saul D, von Heesen M, Friton JJ, Schwarzer AC, Paglilla N, Sheikh SZ, Wegwitz F, Sun Z, Ghadimi M, Newberry RD, et al. RNF20 and RNF40 regulate vitamin D receptor-dependent signaling in inflammatory bowel disease. Cell Death and Differentiation. PMID 34088983 DOI: 10.1038/s41418-021-00808-w  0.355
2020 Toyonaga T, Araba KC, Kennedy MM, Keith BP, Wolber EA, Beasley C, Steinbach EC, Schaner MR, Jain A, Long MD, Barnes EL, Herfarth HH, Isaacs KL, Hansen JJ, Kapadia M, ... ... Sheikh SZ, et al. Increased Colonic Expression of ACE2 Associates with Poor Prognosis in Crohn's disease. Biorxiv : the Preprint Server For Biology. PMID 33269348 DOI: 10.1101/2020.11.24.396382  0.744
2020 Toyonaga T, Steinbach EC, Keith BP, Barrow JB, Schaner MR, Wolber EA, Beasley C, Huling J, Wang Y, Allbritton NL, Chaumont N, Sadiq TS, Koruda MJ, Jain A, Long MD, ... ... Sheikh SZ, et al. Decreased Colonic Activin Receptor-Like Kinase 1 Disrupts Epithelial Barrier Integrity in Patients with Crohn's disease. Cellular and Molecular Gastroenterology and Hepatology. PMID 32561494 DOI: 10.1016/J.Jcmgh.2020.06.005  0.749
2020 Shahir NM, Wang JR, Wolber EA, Schaner MS, Frank DN, Ir D, Robertson CE, Chaumont N, Sadiq TS, Koruda MJ, Rahbar R, Nix BD, Newberry RD, Sartor RB, Sheikh SZ, et al. Crohn's Disease Differentially Affects Region-Specific Composition and Aerotolerance Profiles of Mucosally Adherent Bacteria. Inflammatory Bowel Diseases. PMID 32469069 DOI: 10.1093/Ibd/Izaa103  0.398
2020 Toyonaga T, Keith B, Barrow J, Schaner M, Wolber E, Beasley C, Huling J, Wang Y, Allbritton N, Furey T, Sethupathy P, Sheikh S. P149 DECREASED COLONIC ACTIVIN RECEPTOR-LIKE KINASE 1 DISRUPTS EPITHELIAL BARRIER INTEGRITY AND IS ASSOCIATED WITH A POOR CLINICAL OUTCOME IN CROHN’S DISEASE Gastroenterology. 158: S46. DOI: 10.1053/J.Gastro.2019.11.133  0.317
2019 Furey TS, Sethupathy P, Sheikh SZ. Redefining the IBDs using genome-scale molecular phenotyping. Nature Reviews. Gastroenterology & Hepatology. PMID 30787446 DOI: 10.1038/S41575-019-0118-X  0.383
2018 Keith BP, Barrow JB, Toyonaga T, Kazgan N, O'Connor MH, Shah ND, Schaner MS, Wolber EA, Trad OK, Gipson GR, Pitman WA, Kanke M, Saxena SJ, Chaumont N, Sadiq TS, ... ... Sheikh SZ, et al. Colonic epithelial miR-31 associates with the development of Crohn's phenotypes. Jci Insight. 3. PMID 30282822 DOI: 10.1172/Jci.Insight.122788  0.335
2018 Weaver KN, Kochar B, Hansen JJ, Isaacs KL, Jain A, Long MD, Sheikh S, Herfarth HH, Barnes EL. Su1883 - Older age at the Time of Ileal Pouch-Anal Anastomosis Surgery is Associated with Chronic Antibiotic Dependent Pouchitis in a Multidisciplinary Inflammatory Bowel Disease Center Gastroenterology. 154: S-619. DOI: 10.1016/S0016-5085(18)32229-7  0.322
2017 Lickwar CR, Camp JG, Weiser M, Cocchiaro JL, Kingsley DM, Furey TS, Sheikh SZ, Rawls JF. Genomic dissection of conserved transcriptional regulation in intestinal epithelial cells. Plos Biology. 15: e2002054. PMID 28850571 DOI: 10.1371/Journal.Pbio.2002054  0.307
2016 Weiser M, Simon JM, Kochar B, Tovar A, Israel JW, Robinson A, Gipson GR, Schaner MS, Herfarth HH, Sartor RB, McGovern DP, Rahbar R, Sadiq TS, Koruda MJ, Furey TS, ... Sheikh SZ, et al. Molecular classification of Crohn's disease reveals two clinically relevant subtypes. Gut. PMID 27742763 DOI: 10.1136/Gutjnl-2016-312518  0.325
2016 Simon JM, Davis JP, Lee SE, Schaner MR, Gipson GR, Weiser M, Sartor RB, Herfarth HH, Rahbar R, Sadiq TS, Koruda MJ, McGovern DP, Lieb JD, Mohlke KL, Furey TS, ... Sheikh SZ, et al. Alterations to chromatin in intestinal macrophages link IL-10 deficiency to inappropriate inflammatory responses. European Journal of Immunology. PMID 27159132 DOI: 10.1002/Eji.201546237  0.474
2016 Weiser M, Sheikh S, Kochar B, Gipson G, Herfarth H, Sartor R, McGovern D, Rahbar R, Sadiq T, Furey T, Koruda M, Robinson A. O-004 Analysis of Chromatin and Transcriptional Profiles in Crohn's Disease Reveals Molecular Subclasses and Highlights Functional Regulatory Regions Implicated in Disease. Inflammatory Bowel Diseases. 22: S1-S2. PMID 26849721 DOI: 10.1097/01.Mib.0000480042.88631.E4  0.387
2016 Zhang Y, Li E, Gathungu G, Sheikh S, Sartor RB, Davidson NO, Ciorba MA, Xavier R, Zhu W, Robertson CE, Frank DN. Sa2003 Influence of Crohn's Disease-Related Genetic Defects in Innate Immune Function on Ileal- Associated Microbiome Gastroenterology. 150: S429. DOI: 10.1016/S0016-5085(16)31491-3  0.336
2015 Peck BC, Weiser M, Lee SE, Gipson GR, Iyer VB, Sartor RB, Herfarth HH, Long MD, Hansen JJ, Isaacs KL, Trembath DG, Rahbar R, Sadiq TS, Furey TS, Sethupathy P, ... Sheikh SZ, et al. MicroRNAs Classify Different Disease Behavior Phenotypes of Crohn's Disease and May Have Prognostic Utility. Inflammatory Bowel Diseases. PMID 26164662 DOI: 10.1097/Mib.0000000000000478  0.307
2015 Steinbach EC, Gipson GR, Sheikh SZ. Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+ CD45RB high T Cells into Immunodeficient Mice. Journal of Visualized Experiments : Jove. PMID 25938395 DOI: 10.3791/52533  0.768
2014 Hughes JT, Herfarth HH, Isaacs KL, Plevy SE, Sartor RB, Sheikh SZ, Hansen JJ, Long MD. Infliximab Re-treatment in Inflammatory Bowel Disease: A Single-Center Routine Clinical Experience. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. PMID 24835819 DOI: 10.1016/J.Cgh.2014.05.007  0.566
2014 Onyiah JC, Sheikh SZ, Maharshak N, Otterbein LE, Plevy SE. Heme oxygenase-1 and carbon monoxide regulate intestinal homeostasis and mucosal immune responses to the enteric microbiota. Gut Microbes. 5: 220-4. PMID 24637794 DOI: 10.4161/Gmic.27290  0.647
2014 Steinbach EC, Kobayashi T, Russo SM, Sheikh SZ, Gipson GR, Kennedy ST, Uno JK, Mishima Y, Borst LB, Liu B, Herfarth H, Ting JP, Sartor RB, Plevy SE. Innate PI3K p110δ regulates Th1/Th17 development and microbiota-dependent colitis. Journal of Immunology (Baltimore, Md. : 1950). 192: 3958-68. PMID 24634494 DOI: 10.4049/Jimmunol.1301533  0.805
2014 Kobayashi T, Steinbach EC, Russo SM, Matsuoka K, Nochi T, Maharshak N, Borst LB, Hostager B, Garcia-Martinez JV, Rothman PB, Kashiwada M, Sheikh SZ, Murray PJ, Plevy SE. NFIL3-deficient mice develop microbiota-dependent, IL-12/23-driven spontaneous colitis. Journal of Immunology (Baltimore, Md. : 1950). 192: 1918-27. PMID 24442434 DOI: 10.4049/Jimmunol.1301819  0.803
2014 Weiser M, Raulerson C, Robinson A, Gipson G, Sujino T, Takeuchi O, Kobayashi T, Herfarth HH, Sartor RB, McGovern DP, Lieb JD, Furey TS, Sheikh SZ. Tu1927 Genetically Driven Chromatin Organization Identifies Regulatory SNPs Associated With Crohn's Disease Gastroenterology. 146: S-874. DOI: 10.1016/S0016-5085(14)63181-4  0.35
2014 Sheikh SZ, Plevy SE. Gastrointestinal immunology and ecology Gastrointestinal Anatomy and Physiology: the Essentials. 46-57. DOI: 10.1002/9781118833001.ch4  0.538
2013 Onyiah JC, Sheikh SZ, Maharshak N, Steinbach EC, Russo SM, Kobayashi T, Mackey LC, Hansen JJ, Moeser AJ, Rawls JF, Borst LB, Otterbein LE, Plevy SE. Carbon monoxide and heme oxygenase-1 prevent intestinal inflammation in mice by promoting bacterial clearance. Gastroenterology. 144: 789-98. PMID 23266559 DOI: 10.1053/J.Gastro.2012.12.025  0.779
2013 Hughes J, Herfarth H, Isaacs K, Plevy S, Sartor BR, Sheikh S, Hansen J, Long M. Infliximab Retreatment in Inflammatory Bowel Disease: A Single-center Experience American Journal of Gastroenterology. 108: S543. DOI: 10.14309/00000434-201310001-01801  0.582
2012 Kobayashi T, Matsuoka K, Sheikh SZ, Russo SM, Mishima Y, Collins C, deZoeten EF, Karp CL, Ting JP, Sartor RB, Plevy SE. IL-10 regulates Il12b expression via histone deacetylation: implications for intestinal macrophage homeostasis. Journal of Immunology (Baltimore, Md. : 1950). 189: 1792-9. PMID 22786766 DOI: 10.4049/Jimmunol.1200042  0.654
2012 Onyiah JC, Sheikh SZ, Maharshak N, Russo S, Steinbach EC, Kobayashi T, Mackey LC, Moeser AJ, Rawls JF, Otterbein LE, Plevy SE. 514 Heme Oxygenase-1 Maintains Intestinal Homeostasis Through Augmented Enteric Bacterial Clearance Gastroenterology. 142: S-107. DOI: 10.1016/S0016-5085(12)60404-1  0.767
2011 Sheikh SZ, Hegazi RA, Kobayashi T, Onyiah JC, Russo SM, Matsuoka K, Sepulveda AR, Li F, Otterbein LE, Plevy SE. An anti-inflammatory role for carbon monoxide and heme oxygenase-1 in chronic Th2-mediated murine colitis. Journal of Immunology (Baltimore, Md. : 1950). 186: 5506-13. PMID 21444764 DOI: 10.4049/Jimmunol.1002433  0.667
2011 Kobayashi T, Matsuoka K, Sheikh SZ, Elloumi HZ, Kamada N, Hisamatsu T, Hansen JJ, Doty KR, Pope SD, Smale ST, Hibi T, Rothman PB, Kashiwada M, Plevy SE. NFIL3 is a regulator of IL-12 p40 in macrophages and mucosal immunity. Journal of Immunology (Baltimore, Md. : 1950). 186: 4649-55. PMID 21383239 DOI: 10.4049/Jimmunol.1003888  0.69
2011 Sheikh SZ, Kobayashi T, Matsuoka K, Onyiah JC, Plevy SE. Characterization of an interferon-stimulated response element (ISRE) in the Il23a promoter. The Journal of Biological Chemistry. 286: 1174-80. PMID 21097874 DOI: 10.1074/Jbc.M110.147884  0.657
2011 Kobayashi T, Matsuoka K, Sheikh S, de Zoeten E, Plevy S. Epigenetic regulation of IL-12 p40 by IL-10 in intestinal immunity Inflammatory Bowel Diseases. 17: S11. DOI: 10.1097/00054725-201112002-00032  0.622
2011 Sheikh SZ, Maharshak N, Onyiah J, Rawls J, Plevy S. Heme oxygenase-1 expression and function is protective against innate immune responses to the enteric microbiota Inflammatory Bowel Diseases. 17: S66. DOI: 10.1016/S0016-5085(09)60678-8  0.575
2011 Sheikh SZ, Uno J, Matsuoka K, Plevy SE. Reply to L. Xue and Q. Ouyang, "Diagnostic criteria of inflammatory bowel disease", Clinical Immunology. 139: 104. DOI: 10.1016/J.Clim.2011.01.005  0.553
2010 Sheikh SZ, Plevy SE. The role of the macrophage in sentinel responses in intestinal immunity. Current Opinion in Gastroenterology. 26: 578-82. PMID 20717022 DOI: 10.1097/Mog.0B013E32833D4B71  0.611
2010 Uno JK, Rao KN, Matsuoka K, Sheikh SZ, Kobayashi T, Li F, Steinbach EC, Sepulveda AR, Vanhaesebroeck B, Sartor RB, Plevy SE. Altered macrophage function contributes to colitis in mice defective in the phosphoinositide-3 kinase subunit p110δ. Gastroenterology. 139: 1642-53, 1653.e1-6. PMID 20637203 DOI: 10.1053/J.Gastro.2010.07.008  0.784
2010 Sheikh SZ, Matsuoka K, Kobayashi T, Li F, Rubinas T, Plevy SE. Cutting edge: IFN-gamma is a negative regulator of IL-23 in murine macrophages and experimental colitis. Journal of Immunology (Baltimore, Md. : 1950). 184: 4069-73. PMID 20228197 DOI: 10.4049/Jimmunol.0903600  0.65
2010 Kobayashi T, Matsuoka K, Sheikh SZ, Elloumi HZ, Plevy SE. S1756 The Bzip Protein E4bp4 Mediates IL-10 Regulation of Intestinal Macrophage Tolerance to the Enteric Microbiota Gastroenterology. 138: S-267-S-268. DOI: 10.1016/S0016-5085(10)61226-7  0.65
2010 Uno JK, Matsuoka K, Sheikh SZ, Li F, Steinbach EC, Russo S, Sartor RB, Plevy SE. 756 Functional Deficits in IL-10 and Phosphatidyl Inositol-3 Kinase (PI3K) Contribute to the Development of Severe Colitis Gastroenterology. 138: S-104. DOI: 10.1016/S0016-5085(10)60477-5  0.763
2009 Matsuoka K, Sheikh SZ, Li F, Uno JK, Plevy SE. S1719 Macrophage Tolerance to the Enteric Microbiota Is Mediated By IL-10 At the Chromatin Level Gastroenterology. 136: A-256. DOI: 10.1016/S0016-5085(09)61165-3  0.618
2009 Uno JK, Rao KN, Matsuoka K, Sheikh SZ, Li F, Plevy SE. 1092 Altered Macrophage Function Contributes to Colitis Development in PI3K P110δ Mutant Mice Gastroenterology. 136: A-168. DOI: 10.1016/S0016-5085(09)60759-9  0.59
2009 Sheikh SZ, Matsuoka K, Uno JK, Li F, Plevy SE. 980 Heme Oxygenase-1 Expression and Function Is Protective Against Innate Immune Responses to the Enteric Microbiota Gastroenterology. 136: A-150-A-151. DOI: 10.1016/S0016-5085(09)60678-8  0.529
2009 Sheikh SZ, Matsuoka K, Uno JK, Li F, Plevy SE. 367 Molecular Regulation of Il23a Gene Expression in Murine Macrophages and Experimental Colitis Gastroenterology. 136: A-60. DOI: 10.1016/S0016-5085(09)60270-5  0.652
2008 Sheikh S, Uno J, Matsuoka K, Plevy S. Abnormal mucosal immune response to altered bacterial flora following restorative proctocolectomy in patients with ulcerative colitis: serologic measures, immunogenetics, and clinical correlations. Clinical Immunology (Orlando, Fla.). 127: 270-9. PMID 18499066 DOI: 10.1016/J.Clim.2008.03.511  0.623
2008 Matsuoka K, Sheikh S, Li F, Uno J, Plevy S. NOD2 activates NF-kB p65 serine phosphorylation through a phosphatidylinositol 3-kinase dependant pathway: O-009. Inflammatory Bowel Diseases. 14. DOI: 10.1097/00054725-200801001-00009  0.509
2008 Matsuoka K, Sheikh S, Li F, Plevy S. Sa.123. NOD2 Activates NF-κB p65 Serine Phosphorylation Through a Phosphatidylinositol 3-kinase Dependent Pathway Clinical Immunology. 127: S121. DOI: 10.1016/J.Clim.2008.03.344  0.517
2008 Sheikh S, Matsuoka K, Li F, Plevy S. Sa.118. Molecular Regulation of IL-23 p19 Gene Expression in Macrophages and Murine Inflammatory Bowel Disease Clinical Immunology. 127: S119. DOI: 10.1016/J.Clim.2008.03.339  0.647
2006 Sheikh S, Plevy S. Medical Management of Surgical Inflammatory Bowel Disease? Current Concepts and Future Possibilities Seminars in Colon and Rectal Surgery. 17: 50-54. DOI: 10.1053/J.Scrs.2006.06.007  0.579
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