Jamshid Tanha - Publications

Affiliations: 
Biochemistry, Microbiology and Immunology University of Ottawa, Ottawa, ON, Canada 
Area:
Microbiology Biology, Immunology, Toxicology

71 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Kim DY, Kandalaft H, Lowden MJ, Yang Q, Rossotti MA, Robotham A, Kelly JF, Hussack G, Schrag JD, Henry KA, Tanha J. Sequence tolerance of immunoglobulin variable domain framework regions to non-canonical intradomain disulfide linkages. The Journal of Biological Chemistry. 105278. PMID 37742917 DOI: 10.1016/j.jbc.2023.105278  0.711
2023 Hussack G, Rossotti MA, van Faassen H, Murase T, Eugenio L, Schrag JD, Ng KK, Tanha J. Corrigendum: Structure-guided design of a potent toxin A inhibitor. Frontiers in Microbiology. 14: 1167817. PMID 37065148 DOI: 10.3389/fmicb.2023.1167817  0.596
2023 Hussack G, Rossotti MA, van Faassen H, Murase T, Eugenio L, Schrag JD, Ng KK, Tanha J. Structure-guided design of a potent toxin A inhibitor. Frontiers in Microbiology. 14: 1110541. PMID 36778856 DOI: 10.3389/fmicb.2023.1110541  0.634
2022 Rossotti MA, van Faassen H, Tran AT, Sheff J, Sandhu JK, Duque D, Hewitt M, Wen X, Bavananthasivam J, Beitari S, Matte K, Laroche G, Giguère PM, Gervais C, Stuible M, ... ... Tanha J, et al. Arsenal of nanobodies shows broad-spectrum neutralization against SARS-CoV-2 variants of concern in vitro and in vivo in hamster models. Communications Biology. 5: 933. PMID 36085335 DOI: 10.1038/s42003-022-03866-z  0.74
2021 Bélanger K, Tanha J. High-efficacy, high-manufacturability human VH domain antibody therapeutics from transgenic sources. Protein Engineering, Design & Selection : Peds. 34. PMID 33991089 DOI: 10.1093/protein/gzab012  0.47
2021 Rossotti MA, Bélanger K, Henry KA, Tanha J. Immunogenicity and humanization of single-domain antibodies. The Febs Journal. PMID 33751827 DOI: 10.1111/febs.15809  0.395
2020 van Faassen H, Ryan S, Henry KA, Raphael S, Yang Q, Rossotti MA, Brunette E, Jiang S, Haqqani AS, Sulea T, MacKenzie CR, Tanha J, Hussack G. Serum albumin-binding V Hs with variable pH sensitivities enable tailored half-life extension of biologics. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32342547 DOI: 10.1096/Fj.201903231R  0.709
2019 Bélanger K, Iqbal U, Tanha J, MacKenzie R, Moreno M, Stanimirovic D. Single-Domain Antibodies as Therapeutic and Imaging Agents for the Treatment of CNS Diseases. Antibodies (Basel, Switzerland). 8. PMID 31544833 DOI: 10.3390/Antib8020027  0.487
2019 Togtema M, Hussack G, Dayer G, Teghtmeyer MR, Raphael S, Tanha J, Zehbe I. Single-Domain Antibodies Represent Novel Alternatives to Monoclonal Antibodies as Targeting Agents against the Human Papillomavirus 16 E6 Protein. International Journal of Molecular Sciences. 20. PMID 31035322 DOI: 10.3390/Ijms20092088  0.749
2019 Kim DY, Kandalaft H, Hussack G, Raphael S, Ding W, Kelly JF, Henry KA, Tanha J. Evaluation of a non-canonical Cys40-Cys55 disulfide linkage for stabilization of single-domain antibodies. Protein Science : a Publication of the Protein Society. PMID 30803088 DOI: 10.1002/Pro.3595  0.754
2019 D'Eall C, Pon RA, Rossotti MA, Krahn N, Spearman M, Callaghan D, van Faassen H, Hussack G, Stetefeld J, Butler M, Durocher Y, Zhang J, Henry KA, Tanha J. Modulation of antibody-dependent cellular cytotoxicity of EGFR-specific heavy-chain antibodies through hinge engineering. Immunology and Cell Biology. PMID 30680791 DOI: 10.1111/Imcb.12238  0.772
2019 Rossotti MA, Henry KA, van Faassen H, Tanha J, Callaghan D, Hussack G, Arbabi-Ghahroudi M, MacKenzie CR. Camelid single-domain antibodies raised by DNA immunization are potent inhibitors of EGFR signaling. The Biochemical Journal. 476: 39-50. PMID 30455372 DOI: 10.1042/Bcj20180795  0.73
2018 Hussack G, Ryan S, van Faassen H, Rossotti M, MacKenzie CR, Tanha J. Neutralization of Clostridium difficile toxin B with VHH-Fc fusions targeting the delivery and CROPs domains. Plos One. 13: e0208978. PMID 30540857 DOI: 10.1371/Journal.Pone.0208978  0.746
2018 Henry KA, Tanha J. Performance evaluation of phage-displayed synthetic human single-domain antibody libraries: A retrospective analysis. Journal of Immunological Methods. PMID 29462605 DOI: 10.1016/J.Jim.2018.02.009  0.529
2018 Sulea T, Hussack G, Ryan S, Tanha J, Purisima EO. Application of Assisted Design of Antibody and Protein Therapeutics (ADAPT) improves efficacy of a Clostridium difficile toxin A single-domain antibody. Scientific Reports. 8: 2260. PMID 29396522 DOI: 10.1038/S41598-018-20599-4  0.762
2017 Henry KA, Kim DY, Kandalaft H, Lowden MJ, Yang Q, Schrag JD, Hussack G, MacKenzie CR, Tanha J. Stability-Diversity Tradeoffs Impose Fundamental Constraints on Selection of Synthetic Human VH/VL Single-Domain Antibodies from In Vitro Display Libraries. Frontiers in Immunology. 8: 1759. PMID 29375542 DOI: 10.3389/Fimmu.2017.01759  0.766
2017 Henry KA, Kandalaft H, Lowden MJ, Rossotti MA, van Faassen H, Hussack G, Durocher Y, Kim DY, Tanha J. A disulfide-stabilized human VL single-domain antibody library is a source of soluble and highly thermostable binders. Molecular Immunology. 90: 190-196. PMID 28820969 DOI: 10.1016/J.Molimm.2017.07.006  0.778
2017 Wong WY, Tanha J, Krishnan L, Tian B, Kumar P, Gaspar K, Demas S, Rohmann S, Chao H. Abstract A74: CAR-T cells harboring camelid single domain antibody as targeting agent to CEACAM6 antigen in pancreatic cancer Cancer Immunology Research. 5. DOI: 10.1158/2326-6074.Tumimm16-A74  0.392
2016 Henry KA, Hussack G, Collins C, Zwaagstra JC, Tanha J, MacKenzie CR. Isolation of TGF-β-neutralizing single-domain antibodies of predetermined epitope specificity using next-generation DNA sequencing. Protein Engineering, Design & Selection : Peds. PMID 27613412 DOI: 10.1093/Protein/Gzw043  0.722
2016 Hussack G, Tanha J. An update on antibody-based immunotherapies for Clostridium difficile infection. Clinical and Experimental Gastroenterology. 9: 209-24. PMID 27536153 DOI: 10.2147/Ceg.S84017  0.74
2015 Henry KA, Tanha J, Hussack G. Identification of cross-reactive single-domain antibodies against serum albumin using next-generation DNA sequencing. Protein Engineering, Design & Selection : Peds. 28: 379-83. PMID 26319004 DOI: 10.1093/Protein/Gzv039  0.725
2015 Kandalaft H, Hussack G, Aubry A, van Faassen H, Guan Y, Arbabi-Ghahroudi M, MacKenzie R, Logan SM, Tanha J. Targeting surface-layer proteins with single-domain antibodies: a potential therapeutic approach against Clostridium difficile-associated disease. Applied Microbiology and Biotechnology. PMID 25936376 DOI: 10.1007/S00253-015-6594-1  0.758
2014 Kim DY, Hussack G, Kandalaft H, Tanha J. Mutational approaches to improve the biophysical properties of human single-domain antibodies. Biochimica Et Biophysica Acta. 1844: 1983-2001. PMID 25065345 DOI: 10.1016/J.Bbapap.2014.07.008  0.773
2014 Hussack G, Riazi A, Ryan S, van Faassen H, MacKenzie R, Tanha J, Arbabi-Ghahroudi M. Protease-resistant single-domain antibodies inhibit Campylobacter jejuni motility. Protein Engineering, Design & Selection : Peds. 27: 191-8. PMID 24742504 DOI: 10.1093/Protein/Gzu011  0.737
2014 Kim DY, To R, Kandalaft H, Ding W, Van Faassen H, Luo Y, Schrag JD, St-Amant N, Hefford M, Hirama T, Kelly JF, MacKenzie R, Tanha J. Antibody light chain variable domains and their biophysically improved versions for human immunotherapy Mabs. 6: 219-235. PMID 24423624 DOI: 10.4161/mabs.26844  0.421
2014 Murase T, Eugenio L, Schorr M, Hussack G, Tanha J, Kitova EN, Klassen JS, Ng KK. Structural basis for antibody recognition in the receptor-binding domains of toxins A and B from Clostridium difficile. The Journal of Biological Chemistry. 289: 2331-43. PMID 24311789 DOI: 10.1074/Jbc.M113.505917  0.742
2013 Drake P, Jiang PS, Chang HW, Su SC, Tanha J, Tay LL, Chen P, Lin YJ. Raman based detection of Staphylococcus aureus utilizing single domain antibody coated nanoparticle labels and magnetic trapping Analytical Methods. 5: 4152-4158. DOI: 10.1039/C3Ay40652K  0.306
2012 Kim DY, Kandalaft H, Ding W, Ryan S, van Faassen H, Hirama T, Foote SJ, MacKenzie R, Tanha J. Disulfide linkage engineering for improving biophysical properties of human VH domains. Protein Engineering, Design & Selection : Peds. 25: 581-9. PMID 22942392 DOI: 10.1093/Protein/Gzs055  0.475
2012 Hussack G, Mackenzie CR, Tanha J. Characterization of single-domain antibodies with an engineered disulfide bond. Methods in Molecular Biology (Clifton, N.J.). 911: 417-29. PMID 22886266 DOI: 10.1007/978-1-61779-968-6_25  0.763
2012 Kim DY, Ding W, Tanha J. Solubility and stability engineering of human VH domains. Methods in Molecular Biology (Clifton, N.J.). 911: 355-72. PMID 22886262 DOI: 10.1007/978-1-61779-968-6_21  0.415
2012 Hussack G, Arbabi-Ghahroudi M, Mackenzie CR, Tanha J. Isolation and characterization of Clostridium difficile toxin-specific single-domain antibodies. Methods in Molecular Biology (Clifton, N.J.). 911: 211-39. PMID 22886255 DOI: 10.1007/978-1-61779-968-6_14  0.786
2012 Aubry A, Hussack G, Chen W, KuoLee R, Twine SM, Fulton KM, Foote S, Carrillo CD, Tanha J, Logan SM. Modulation of toxin production by the flagellar regulon in Clostridium difficile. Infection and Immunity. 80: 3521-32. PMID 22851750 DOI: 10.1128/Iai.00224-12  0.645
2012 Hussack G, Keklikian A, Alsughayyir J, Hanifi-Moghaddam P, Arbabi-Ghahroudi M, van Faassen H, Hou ST, Sad S, MacKenzie R, Tanha J. A V(L) single-domain antibody library shows a high-propensity to yield non-aggregating binders. Protein Engineering, Design & Selection : Peds. 25: 313-8. PMID 22490957 DOI: 10.1093/Protein/Gzs014  0.701
2012 Baral TN, Chao SY, Li S, Tanha J, Arbabi-Ghahroudi M, Zhang J, Wang S. Crystal structure of a human single domain antibody dimer formed through V(H)-V(H) non-covalent interactions. Plos One. 7: e30149. PMID 22253912 DOI: 10.1371/Journal.Pone.0030149  0.442
2012 Tay LL, Huang PJ, Tanha J, Ryan S, Wu X, Hulse J, Chau LK. Silica encapsulated SERS nanoprobe conjugated to the bacteriophage tailspike protein for targeted detection of Salmonella. Chemical Communications (Cambridge, England). 48: 1024-6. PMID 22158658 DOI: 10.1039/C1Cc16325F  0.318
2011 Hussack G, Hirama T, Ding W, Mackenzie R, Tanha J. Engineered single-domain antibodies with high protease resistance and thermal stability. Plos One. 6: e28218. PMID 22140551 DOI: 10.1371/Journal.Pone.0028218  0.718
2011 Hussack G, Arbabi-Ghahroudi M, van Faassen H, Songer JG, Ng KK, MacKenzie R, Tanha J. Neutralization of Clostridium difficile toxin A with single-domain antibodies targeting the cell receptor binding domain. The Journal of Biological Chemistry. 286: 8961-76. PMID 21216961 DOI: 10.1074/Jbc.M110.198754  0.754
2011 Wang S, Baral TN, Chao S, Li S, Tanha J, Arbabi-Ghahroudi M, Zhang J. Crystal structure of a dimeric anti-HER2 human single domain antibody Acta Crystallographica Section a Foundations of Crystallography. 67: C305-C306. DOI: 10.1107/S0108767311092348  0.373
2010 Hussack G, Tanha J. Toxin-specific antibodies for the treatment of Clostridium difficile: current status and future perspectives. Toxins. 2: 998-1018. PMID 22069622 DOI: 10.3390/Toxins2050998  0.74
2010 Waseh S, Hanifi-Moghaddam P, Coleman R, Masotti M, Ryan S, Foss M, MacKenzie R, Henry M, Szymanski CM, Tanha J. Orally administered P22 phage tailspike protein reduces salmonella colonization in chickens: prospects of a novel therapy against bacterial infections. Plos One. 5: e13904. PMID 21124920 DOI: 10.1371/Journal.Pone.0013904  0.369
2010 Arbabi-Ghahroudi M, Mackenzie R, Tanha J. Site-directed mutagenesis for improving biophysical properties of VH domains. Methods in Molecular Biology (Clifton, N.J.). 634: 309-30. PMID 20676993 DOI: 10.1007/978-1-60761-652-8_22  0.508
2010 Singh A, Arya SK, Glass N, Hanifi-Moghaddam P, Naidoo R, Szymanski CM, Tanha J, Evoy S. Bacteriophage tailspike proteins as molecular probes for sensitive and selective bacterial detection. Biosensors & Bioelectronics. 26: 131-8. PMID 20541928 DOI: 10.1016/J.Bios.2010.05.024  0.365
2010 Kim DY, Tanha J. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis for screening nonaggregating human antibody heavy chain variable domains. Analytical Biochemistry. 403: 117-9. PMID 20406618 DOI: 10.1016/J.Ab.2010.04.017  0.393
2009 Hussack G, Luo Y, Veldhuis L, Hall JC, Tanha J, Mackenzie R. Multivalent anchoring and oriented display of single-domain antibodies on cellulose. Sensors (Basel, Switzerland). 9: 5351-67. PMID 22346702 DOI: 10.3390/S90705351  0.77
2009 Ryan S, Kell AJ, van Faassen H, Tay LL, Simard B, MacKenzie R, Gilbert M, Tanha J. Single-domain antibody-nanoparticles: promising architectures for increased staphylococcus aureus detection specificity and sensitivity. Bioconjugate Chemistry. 20: 1966-74. PMID 19751063 DOI: 10.1021/Bc900332R  0.519
2009 Huang PJ, Tay LL, Tanha J, Ryan S, Chau LK. Single-domain antibody-conjugated nanoaggregate-embedded beads for targeted detection of pathogenic bacteria. Chemistry (Weinheim An Der Bergstrasse, Germany). 15: 9330-4. PMID 19655352 DOI: 10.1002/Chem.200901397  0.493
2009 Ng A, Tanha J, Narang S, Ni F. Design, selection and binding mechanism of bivalent miniproteins targeting human thrombin. Advances in Experimental Medicine and Biology. 611: 417-8. PMID 19400247 DOI: 10.1007/978-0-387-73657-0_180  0.355
2009 Arbabi-Ghahroudi M, MacKenzie R, Tanha J. Selection of non-aggregating VH binders from synthetic VH phage-display libraries. Methods in Molecular Biology (Clifton, N.J.). 525: 187-216, xiii. PMID 19252860 DOI: 10.1007/978-1-59745-554-1_10  0.486
2009 Arbabi-Ghahroudi M, Tanha J, MacKenzie R. Isolation of monoclonal antibody fragments from phage display libraries. Methods in Molecular Biology (Clifton, N.J.). 502: 341-64. PMID 19082566 DOI: 10.1007/978-1-60327-565-1_20  0.523
2009 Arbabi-Ghahroudi M, To R, Gaudette N, Hirama T, Ding W, MacKenzie R, Tanha J. Aggregation-resistant VHs selected by in vitro evolution tend to have disulfide-bonded loops and acidic isoelectric points Protein Engineering, Design and Selection. 22: 59-66. PMID 19033278 DOI: 10.1093/Protein/Gzn071  0.502
2009 McGonigal K, Tanha J, Palazov E, Li S, Gueorguieva-Owens D, Pandey S. Isolation and functional characterization of single domain antibody modulators of Caspase-3 and apoptosis. Applied Biochemistry and Biotechnology. 157: 226-36. PMID 18553063 DOI: 10.1007/S12010-008-8266-4  0.329
2009 Tay LL, Hulse J, Ryan S, Tanha J, Fraser J, Wu X. Multimodal plasmonic nanosensor for the detection of pathogenic bacteria Proceedings of Spie - the International Society For Optical Engineering. 7397. DOI: 10.1117/12.826093  0.319
2007 Nielsen K, Yu WL, Lin M, Davis SAN, Elmgren C, MacKenzie R, Tanha J, Li S, Dubuc G, Brown EG, Keleta L, Pasick J. Prototype single step lateral flow technology for detection of avian influenza virus and chicken antibody to avian influenza virus Journal of Immunoassay and Immunochemistry. 28: 307-318. PMID 17885885 DOI: 10.1080/15321810701603443  0.404
2007 Noestheden M, Hu Q, Tay LL, Tonary AM, Stolow A, MacKenzie R, Tanha J, Pezacki JP. Synthesis and characterization of CN-modified protein analogues as potential vibrational contrast agents. Bioorganic Chemistry. 35: 284-93. PMID 17316745 DOI: 10.1016/J.Bioorg.2006.12.004  0.515
2007 Stone E, Hirama T, Tanha J, Tong-Sevinc H, Li S, MacKenzie CR, Zhang J. The assembly of single domain antibodies into bispecific decavalent molecules. Journal of Immunological Methods. 318: 88-94. PMID 17141798 DOI: 10.1016/J.Jim.2006.10.006  0.566
2006 Gueorguieva D, Li S, Walsh N, Mukerji A, Tanha J, Pandey S. Identification of single-domain, Bax-specific intrabodies that confer resistance to mammalian cells against oxidative-stress-induced apoptosis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 2636-8. PMID 17060401 DOI: 10.1096/Fj.06-6306Fje  0.369
2006 Tanha J, Nguyen TD, Ng A, Ryan S, Ni F, Mackenzie R. Improving solubility and refolding efficiency of human V(H)s by a novel mutational approach. Protein Engineering, Design & Selection : Peds. 19: 503-9. PMID 16971398 DOI: 10.1093/Protein/Gzl037  0.456
2005 Arbabi-Ghahroudi M, Tanha J, MacKenzie R. Prokaryotic expression of antibodies. Cancer Metastasis Reviews. 24: 501-19. PMID 16408159 DOI: 10.1007/S10555-005-6193-1  0.506
2005 To R, Hirama T, Arbabi-Ghahroudi M, MacKenzie R, Wang P, Xu P, Ni F, Tanha J. Isolation of monomeric human V(H)s by a phage selection. The Journal of Biological Chemistry. 280: 41395-403. PMID 16221664 DOI: 10.1074/Jbc.M509900200  0.407
2005 Yau KY, Dubuc G, Li S, Hirama T, Mackenzie CR, Jermutus L, Hall JC, Tanha J. Affinity maturation of a V(H)H by mutational hotspot randomization. Journal of Immunological Methods. 297: 213-24. PMID 15777944 DOI: 10.1016/J.Jim.2004.12.005  0.495
2005 Abulrob A, Zhang J, Tanha J, MacKenzie R, Stanimirovic D. Single domain antibodies as blood-brain barrier delivery vectors International Congress Series. 1277: 212-223. DOI: 10.1016/j.ics.2005.02.024  0.326
2004 Zhang J, Tanha J, Hirama T, Khieu NH, To R, Tong-Sevinc H, Stone E, Brisson JR, MacKenzie CR. Pentamerization of single-domain antibodies from phage libraries: a novel strategy for the rapid generation of high-avidity antibody reagents. Journal of Molecular Biology. 335: 49-56. PMID 14659739 DOI: 10.1016/J.Jmb.2003.09.034  0.572
2003 Yau KY, Groves MA, Li S, Sheedy C, Lee H, Tanha J, MacKenzie CR, Jermutus L, Hall JC. Selection of hapten-specific single-domain antibodies from a non-immunized llama ribosome display library. Journal of Immunological Methods. 281: 161-75. PMID 14580890 DOI: 10.1016/J.Jim.2003.07.011  0.466
2003 Tanha J, Muruganandam A, Stanimirovic D. Phage display technology for identifying specific antigens on brain endothelial cells. Methods in Molecular Medicine. 89: 435-49. PMID 12958438 DOI: 10.1385/1-59259-419-0:435  0.312
2002 Vranken W, Tolkatchev D, Xu P, Tanha J, Chen Z, Narang S, Ni F. Solution structure of a llama single-domain antibody with hydrophobic residues typical of the VH/VL interface. Biochemistry. 41: 8570-9. PMID 12093273 DOI: 10.1021/Bi012169A  0.398
2002 Tanha J, Dubuc G, Hirama T, Narang SA, MacKenzie CR. Selection by phage display of llama conventional V(H) fragments with heavy chain antibody V(H)H properties. Journal of Immunological Methods. 263: 97-109. PMID 12009207 DOI: 10.1016/S0022-1759(02)00027-3  0.481
2002 Muruganandam A, Tanha J, Narang S, Stanimirovic D. Selection of phage-displayed llama single-domain antibodies that transmigrate across human blood-brain barrier endothelium. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 240-2. PMID 11772942 DOI: 10.1096/Fj.01-0343Fje  0.446
2001 Tanha J, Xu P, Chen Z, Ni F, Kaplan H, Narang SA, MacKenzie CR. Optimal Design Features of Camelized Human Single-domain Antibody Libraries Journal of Biological Chemistry. 276: 24774-24780. PMID 11335716 DOI: 10.1074/Jbc.M100770200  0.463
1997 Lee JS, Latimer LJ, Tanha J. Analysis of DNA-binding antibodies Methods in Molecular Biology (Clifton, N.J.). 90: 181-188. PMID 9407535 DOI: 10.1385/0-89603-447-X:181  0.327
1997 Tanha J, Forsyth G, Schorr P, Crosby W, Lee JS. Sequence and structure specific antibodies from phage display libraries Molecular Immunology. 34: 109-113. PMID 9188843 DOI: 10.1016/S0161-5890(97)00015-1  0.308
1994 Kuderova A, Tanha J, Lee JS. Characterization of four nucleic acid-binding single-chain Fv fragments by direct and competitive solid-phase radioimmunoassays Journal of Biological Chemistry. 269: 32957-32962. PMID 7806525  0.33
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