Philip A. Cole - Publications

1996-1999 Bioorganic Chemistry Rockefeller University, New York, NY, United States 
 1999- Pharmacology and Molecular Sciences Johns Hopkins University, Baltimore, MD 
Pharmacology, Biochemistry

212 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Ji Z, Clark RF, Bhat V, Matthew Hansen T, Lasko LM, Bromberg KD, Manaves V, Algire M, Martin R, Qiu W, Torrent M, Jakob CG, Liu H, Cole PA, Marmorstein R, et al. Discovery of Spirohydantoins as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases. Bioorganic & Medicinal Chemistry Letters. 127854. PMID 33631370 DOI: 10.1016/j.bmcl.2021.127854  0.68
2021 Huang H, Zhang D, Weng Y, Delaney K, Tang Z, Yan C, Qi S, Peng C, Cole PA, Roeder RG, Zhao Y. The regulatory enzymes and protein substrates for the lysine β-hydroxybutyrylation pathway. Science Advances. 7. PMID 33627428 DOI: 10.1126/sciadv.abe2771  0.32
2021 Jiang H, Dempsey DR, Cole PA. Ubiquitin Ligase Activities of WWP1 Germline Variants K740N and N745S. Biochemistry. PMID 33470109 DOI: 10.1021/acs.biochem.0c00869  0.36
2020 Wang ZA, Cole PA. The Chemical Biology of Reversible Lysine Post-translational Modifications. Cell Chemical Biology. PMID 32698016 DOI: 10.1016/J.Chembiol.2020.07.002  0.84
2020 Wang ZA, Millard CJ, Lin CL, Gurnett JE, Wu M, Lee K, Fairall L, Schwabe JWR, Cole PA. Diverse nucleosome site-selectivity among histone deacetylase complexes. Elife. 9. PMID 32501215 DOI: 10.7554/Elife.57663  0.84
2020 Jiang H, D'Agostino GD, Cole PA, Dempsey DR. Selective protein N-terminal labeling with N-hydroxysuccinimide esters. Methods in Enzymology. 639: 333-353. PMID 32475408 DOI: 10.1016/Bs.Mie.2020.04.018  0.36
2020 Wang ZA, Cole PA. Methods and Applications of Expressed Protein Ligation. Methods in Molecular Biology (Clifton, N.J.). 2133: 1-13. PMID 32144660 DOI: 10.1007/978-1-0716-0434-2_1  0.84
2020 Xiong Y, Wang L, Di Giorgio E, Akimova T, Beier UH, Han R, Trevisanut M, Kalin JH, Cole PA, Hancock WW. Inhibiting the coregulator CoREST impairs Foxp3+ Treg function and promotes antitumor immunity. The Journal of Clinical Investigation. PMID 31917688 DOI: 10.1172/Jci131375  0.48
2019 Anastas JN, Zee BM, Kalin JH, Kim M, Guo R, Alexandrescu S, Blanco MA, Giera S, Gillespie SM, Das J, Wu M, Nocco S, Bonal DM, Nguyen QD, Suva ML, ... ... Cole PA, et al. Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG. Cancer Cell. PMID 31631026 DOI: 10.1016/J.Ccell.2019.09.005  0.32
2019 Jiang H, Thomas SN, Chen Z, Chiang CY, Cole PA. Comparative analysis of the catalytic regulation of NEDD4-1 and WWP2 ubiquitin ligases. The Journal of Biological Chemistry. PMID 31578285 DOI: 10.1074/Jbc.Ra119.009211  0.36
2019 Van de Velde S, Wiater E, Tran M, Hwang Y, Cole PA, Montminy M. CREB promotes beta cell gene expression by targeting Its coactivators to tissue-specific enhancers. Molecular and Cellular Biology. PMID 31182641 DOI: 10.1128/Mcb.00200-19  0.48
2019 Liu Y, Bao C, Wang L, Han R, Beier UH, Akimova T, Cole PA, Dent SYR, Hancock WW. Complementary Roles of GCN5 and PCAF in Foxp3+ T-Regulatory Cells. Cancers. 11. PMID 31003455 DOI: 10.3390/Cancers11040554  0.48
2019 Zucconi B, Makofske J, Meyers D, Hwang Y, Wu M, Kuroda M, Cole PA. Combination Targeting of the Bromodomain and Acetyltransferase Active Site of p300/CBP. Biochemistry. PMID 30924641 DOI: 10.1021/Acs.Biochem.9B00160  0.48
2019 Kalin JH, Eroglu A, Liu H, Holtzclaw WD, Leigh I, Proby CM, Fahey JW, Cole PA, Dinkova-Kostova AT. Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model. Plos One. 14: e0213095. PMID 30865688 DOI: 10.1371/Journal.Pone.0213095  0.44
2019 Miller MS, Maheshwari S, Shi W, Gao Y, Chu N, Soares AS, Cole PA, Amzel LM, Fuchs MR, Jakoncic J, Gabelli SB. Getting the Most Out of Your Crystals: Data Collection at the New High-Flux, Microfocus MX Beamlines at NSLS-II. Molecules (Basel, Switzerland). 24. PMID 30704096 DOI: 10.3390/Molecules24030496  0.72
2018 Chu N, Salguero AL, Liu AZ, Chen Z, Dempsey DR, Ficarro SB, Alexander WM, Marto JA, Li Y, Amzel LM, Gabelli SB, Cole PA. Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis. Cell. PMID 30078705 DOI: 10.1016/J.Cell.2018.07.003  0.72
2018 Dempsey DR, Jiang H, Kalin JH, Chen Z, Cole PA. Site-specific Protein Labeling with NHS-Esters and the Analysis of Ubiquitin Ligase Mechanisms. Journal of the American Chemical Society. PMID 30016585 DOI: 10.1021/Jacs.8B05098  0.36
2018 Bhat S, Hwang Y, Gibson MD, Morgan MT, Taverna SD, Zhao Y, Wolberger C, Poirier MG, Cole PA. Hydrazide Mimics for Protein Lysine Acylation to Assess Nucleosome Dynamics and Deubiquitinase Action. Journal of the American Chemical Society. PMID 29991262 DOI: 10.1021/Jacs.8B03572  0.48
2018 Lasko LM, Jakob CG, Edalji RP, Qiu W, Montgomery D, Digiammarino EL, Hansen TM, Risi RM, Frey R, Manaves V, Shaw B, Algire M, Hessler P, Lam LT, Uziel T, ... ... Cole PA, et al. Author Correction: Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours. Nature. PMID 29769713 DOI: 10.1038/S41586-018-0111-5  0.68
2018 Michaelides MR, Kluge A, Patane M, Van Drie JH, Wang C, Hansen TM, Risi RM, Mantei R, Hertel C, Karukurichi K, Nesterov A, McElligott D, de Vries P, Langston JW, Cole PA, et al. Discovery of Spiro Oxazolidinediones as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases. Acs Medicinal Chemistry Letters. 9: 28-33. PMID 29348807 DOI: 10.1021/Acsmedchemlett.7B00395  0.68
2018 Wang Z, Kim MS, Martinez Ferrando I, Koleske AJ, Pandey A, Cole PA. Analysis of Cellular Tyrosine Phosphorylation via Chemical Rescue of Conditionally Active Abl Kinase. Biochemistry. PMID 29341593 DOI: 10.1021/Acs.Biochem.7B01158  1
2017 Lasko LM, Jakob CG, Edalji RP, Qiu W, Montgomery D, Digiammarino EL, Hansen TM, Risi RM, Frey R, Manaves V, Shaw B, Algire M, Hessler P, Lam LT, Uziel T, ... ... Cole PA, et al. Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours. Nature. PMID 28953875 DOI: 10.1038/Nature24028  0.68
2017 Chen Z, Jiang H, Xu W, Li X, Dempsey DR, Zhang X, Devreotes P, Wolberger C, Amzel LM, Gabelli SB, Cole PA. A Tunable Brake for HECT Ubiquitin Ligases. Molecular Cell. 66: 345-357.e6. PMID 28475870 DOI: 10.1016/J.Molcel.2017.03.020  0.72
2017 Mo GC, Ross B, Hertel F, Manna P, Yang X, Greenwald E, Booth C, Plummer AM, Tenner B, Chen Z, Wang Y, Kennedy EJ, Cole PA, Fleming KG, Palmer A, et al. Genetically encoded biosensors for visualizing live-cell biochemical activity at super-resolution. Nature Methods. PMID 28288122 DOI: 10.1038/Nmeth.4221  0.44
2016 Henager SH, Chu N, Chen Z, Bolduc D, Dempsey DR, Hwang Y, Wells J, Cole PA. Enzyme-catalyzed expressed protein ligation. Nature Methods. PMID 27669326 DOI: 10.1038/Nmeth.4004  1
2016 Hsiao PY, Kalin J, Sun IH, Amin M, Lo YC, Chiang MJ, Giddens J, Sysa-Shah P, Gabrielson K, Wang LX, Powell J, Cole PA. An Fc-Small Molecule Conjugate for Targeted Inhibition of the Adenosine 2A Receptor. Chembiochem : a European Journal of Chemical Biology. PMID 27432157 DOI: 10.1002/Cbic.201600337  1
2016 Dancy BM, Cole PA. Correction to Protein Lysine Acetylation by p300/CBP. Chemical Reviews. PMID 27304234 DOI: 10.1021/Acs.Chemrev.6B00351  0.32
2016 Chen Z, Thomas SN, Bolduc DM, Jiang X, Zhang X, Wolberger C, Cole PA. Enzymatic Analysis of PTEN Ubiquitylation by WWP2 and NEDD4-1 E3 ligases. Biochemistry. PMID 27295432 DOI: 10.1021/Acs.Biochem.6B00448  1
2016 Chen Z, Dempsey DR, Thomas SN, Hayward D, Bolduc DM, Cole PA. Molecular Features of PTEN Regulation by C-Terminal Phosphorylation. The Journal of Biological Chemistry. PMID 27226612 DOI: 10.1074/Jbc.M116.728980  1
2016 Hayward D, Cole PA. LSD1 Histone Demethylase Assays and Inhibition Methods in Enzymology. DOI: 10.1016/bs.mie.2016.01.020  1
2015 Tu S, Guo SJ, Chen CS, Liu CX, Jiang HW, Ge F, Deng JY, Zhou YM, Czajkowsky DM, Li Y, Qi BR, Ahn YH, Cole PA, Zhu H, Tao SC. YcgC represents a new protein deacetylase family in prokaryotes. Elife. 4. PMID 26716769 DOI: 10.7554/Elife.05322  1
2015 Philip P, Boija A, Vaid R, Churcher AM, Meyers DJ, Cole PA, Mannervik M, Stenberg P. CBP binding outside of promoters and enhancers in Drosophila melanogaster. Epigenetics & Chromatin. 8: 48. PMID 26604986 DOI: 10.1186/S13072-015-0042-4  1
2015 Taylor MS, Dempsey DR, Hwang Y, Chen Z, Chu N, Boeke JD, Cole PA. Mechanistic analysis of ghrelin-O-acyltransferase using substrate analogs. Bioorganic Chemistry. 62: 64-73. PMID 26246082 DOI: 10.1016/J.Bioorg.2015.07.003  1
2015 Chen Z, Cole PA. Synthetic approaches to protein phosphorylation. Current Opinion in Chemical Biology. 28: 115-122. PMID 26196731 DOI: 10.1016/J.Cbpa.2015.07.001  0.36
2015 Chu N, Cole PA. Switching immune signals on and off. Elife. 4. PMID 25838130 DOI: 10.7554/Elife.07204  1
2015 He C, Cole P. Introduction: epigenetics. Chemical Reviews. 115: 2223-4. PMID 25804907 DOI: 10.1021/acs.chemrev.5b00137  1
2015 Dancy BM, Cole PA. Protein lysine acetylation by p300/CBP. Chemical Reviews. 115: 2419-52. PMID 25594381 DOI: 10.1021/Cr500452K  1
2015 Chen Z, Cole PA. Synthetic approaches to protein phosphorylation Current Opinion in Chemical Biology. 28: 115-122. DOI: 10.1016/j.cbpa.2015.07.001  1
2014 Wang Z, Cole PA. Catalytic mechanisms and regulation of protein kinases. Methods in Enzymology. 548: 1-21. PMID 25399640 DOI: 10.1016/B978-0-12-397918-6.00001-X  1
2014 Leurs U, Lohse B, Ming S, Cole PA, Clausen RP, Kristensen JL, Rand KD. Dissecting the binding mode of low affinity phage display peptide ligands to protein targets by hydrogen/deuterium exchange coupled to mass spectrometry. Analytical Chemistry. 86: 11734-41. PMID 25325890 DOI: 10.1021/Ac503137U  1
2014 Kavran JM, McCabe JM, Byrne PO, Connacher MK, Wang Z, Ramek A, Sarabipour S, Shan Y, Shaw DE, Hristova K, Cole PA, Leahy DJ. How IGF-1 activates its receptor. Elife. 3. PMID 25255214 DOI: 10.7554/Elife.03772  1
2014 Wang Y, Kavran JM, Chen Z, Karukurichi KR, Leahy DJ, Cole PA. Regulation of S-adenosylhomocysteine hydrolase by lysine acetylation. The Journal of Biological Chemistry. 289: 31361-72. PMID 25248746 DOI: 10.1074/Jbc.M114.597153  1
2014 Brown LJ, Baranowski M, Wang Y, Schrey AK, Lenz T, Taverna SD, Cole PA, Sefkow M. Using S-adenosyl-L-homocysteine capture compounds to characterize S-adenosyl-L-methionine and S-adenosyl-L-homocysteine binding proteins. Analytical Biochemistry. 467: 14-21. PMID 25172130 DOI: 10.1016/J.Ab.2014.08.013  1
2014 Liu Y, Wang L, Han R, Beier UH, Akimova T, Bhatti T, Xiao H, Cole PA, Brindle PK, Hancock WW. Two histone/protein acetyltransferases, CBP and p300, are indispensable for Foxp3+ T-regulatory cell development and function. Molecular and Cellular Biology. 34: 3993-4007. PMID 25154413 DOI: 10.1128/Mcb.00919-14  1
2014 Miller MS, Schmidt-Kittler O, Bolduc DM, Brower ET, Chaves-Moreira D, Allaire M, Kinzler KW, Jennings IG, Thompson PE, Cole PA, Amzel LM, Vogelstein B, Gabelli SB. Structural basis of nSH2 regulation and lipid binding in PI3Kα. Oncotarget. 5: 5198-208. PMID 25105564 DOI: 10.18632/Oncotarget.2263  1
2014 Leurs U, Lohse B, Rand KD, Ming S, Riise ES, Cole PA, Kristensen JL, Clausen RP. Substrate- and cofactor-independent inhibition of histone demethylase KDM4C. Acs Chemical Biology. 9: 2131-8. PMID 25014588 DOI: 10.1021/Cb500374F  1
2014 Maksimoska J, Segura-Peña D, Cole PA, Marmorstein R. Structure of the p300 histone acetyltransferase bound to acetyl-coenzyme A and its analogues. Biochemistry. 53: 3415-22. PMID 24819397 DOI: 10.1021/Bi500380F  1
2014 Prusevich P, Kalin JH, Ming SA, Basso M, Givens J, Li X, Hu J, Taylor MS, Cieniewicz AM, Hsiao PY, Huang R, Roberson H, Adejola N, Avery LB, Casero RA, ... ... Cole PA, et al. A selective phenelzine analogue inhibitor of histone demethylase LSD1. Acs Chemical Biology. 9: 1284-93. PMID 24707965 DOI: 10.1021/Cb500018S  1
2014 Chiang MJ, Holbert MA, Kalin JH, Ahn YH, Giddens J, Amin MN, Taylor MS, Collins SL, Chan-Li Y, Waickman A, Hsiao PY, Bolduc D, Leahy DJ, Horton MR, Wang LX, ... ... Cole PA, et al. An Fc domain protein-small molecule conjugate as an enhanced immunomodulator. Journal of the American Chemical Society. 136: 3370-3. PMID 24533830 DOI: 10.1021/Ja5006674  1
2014 Wondisford AR, Xiong L, Chang E, Meng S, Meyers DJ, Li M, Cole PA, He L. Control of Foxo1 gene expression by co-activator P300. The Journal of Biological Chemistry. 289: 4326-33. PMID 24379407 DOI: 10.1074/Jbc.M113.540500  1
2014 Zhang Y, Dayalan Naidu S, Samarasinghe K, Van Hecke GC, Pheely A, Boronina TN, Cole RN, Benjamin IJ, Cole PA, Ahn YH, Dinkova-Kostova AT. Sulphoxythiocarbamates modify cysteine residues in HSP90 causing degradation of client proteins and inhibition of cancer cell proliferation. British Journal of Cancer. 110: 71-82. PMID 24322890 DOI: 10.1038/Bjc.2013.710  1
2014 Miller MS, Schmidt-Kittler O, Bolduc DM, Brower ET, Chaves-Moreira D, Allaire M, Kinzler KW, Jennings IG, Thompson PE, Cole PA, Amzel LM, Vogelstein B, Gabelli SB. Structural basis of nSH2 regulation and lipid binding in PI3Kα Oncotarget. 5: 5198-5208.  1
2013 Sugar JG, Chu QD, Cole PA, Li BD, Kim RH. Effect of January vacations and prior night call status on resident ABSITE performance. Journal of Surgical Education. 70: 720-4. PMID 24209647 DOI: 10.1016/J.Jsurg.2013.06.013  0.68
2013 Schröder S, Herker E, Itzen F, He D, Thomas S, Gilchrist DA, Kaehlcke K, Cho S, Pollard KS, Capra JA, Schnölzer M, Cole PA, Geyer M, Bruneau BG, Adelman K, et al. Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cells. Molecular Cell. 52: 314-24. PMID 24207025 DOI: 10.1016/J.Molcel.2013.10.009  1
2013 Taylor MS, Ruch TR, Hsiao PY, Hwang Y, Zhang P, Dai L, Huang CR, Berndsen CE, Kim MS, Pandey A, Wolberger C, Marmorstein R, Machamer C, Boeke JD, Cole PA. Architectural organization of the metabolic regulatory enzyme ghrelin O-acyltransferase. The Journal of Biological Chemistry. 288: 32211-28. PMID 24045953 DOI: 10.1074/Jbc.M113.510313  1
2013 Wang Z, Raines LL, Hooy RM, Roberson H, Leahy DJ, Cole PA. Tyrosine phosphorylation of mig6 reduces its inhibition of the epidermal growth factor receptor. Acs Chemical Biology. 8: 2372-6. PMID 24004111 DOI: 10.1021/Cb4005707  1
2013 Liu Y, Wang L, Predina J, Han R, Beier UH, Wang LC, Kapoor V, Bhatti TR, Akimova T, Singhal S, Brindle PK, Cole PA, Albelda SM, Hancock WW. Inhibition of p300 impairs Foxp3⁺ T regulatory cell function and promotes antitumor immunity. Nature Medicine. 19: 1173-7. PMID 23955711 DOI: 10.1038/Nm.3286  1
2013 Cole PA. Open questions: two challenges in chemical biology--chemical engineering and the science of diet. Bmc Biology. 11: 87. PMID 23899134 DOI: 10.1186/1741-7007-11-87  1
2013 Bolduc D, Rahdar M, Tu-Sekine B, Sivakumaren SC, Raben D, Amzel LM, Devreotes P, Gabelli SB, Cole P. Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis. Elife. 2: e00691. PMID 23853711 DOI: 10.7554/Elife.00691  1
2013 Yan G, Eller MS, Elm C, Larocca CA, Ryu B, Panova IP, Dancy BM, Bowers EM, Meyers D, Lareau L, Cole PA, Taverna SD, Alani RM. Selective inhibition of p300 HAT blocks cell cycle progression, induces cellular senescence, and inhibits the DNA damage response in melanoma cells. The Journal of Investigative Dermatology. 133: 2444-52. PMID 23698071 DOI: 10.1038/Jid.2013.187  1
2013 Newman RH, Hu J, Rho HS, Xie Z, Woodard C, Neiswinger J, Cooper C, Shirley M, Clark HM, Hu S, Hwang W, Jeong JS, Wu G, Lin J, Gao X, ... ... Cole PA, et al. Construction of human activity-based phosphorylation networks. Molecular Systems Biology. 9: 655. PMID 23549483 DOI: 10.1038/Msb.2013.12  1
2012 Taylor MS, Hwang Y, Hsiao PY, Boeke JD, Cole PA. Ghrelin O-acyltransferase assays and inhibition. Methods in Enzymology. 514: 205-28. PMID 22975055 DOI: 10.1016/B978-0-12-381272-8.00013-1  1
2012 Dancy BM, Crump NT, Peterson DJ, Mukherjee C, Bowers EM, Ahn YH, Yoshida M, Zhang J, Mahadevan LC, Meyers DJ, Boeke JD, Cole PA. Live-cell studies of p300/CBP histone acetyltransferase activity and inhibition. Chembiochem : a European Journal of Chemical Biology. 13: 2113-21. PMID 22961914 DOI: 10.1002/Cbic.201200381  1
2012 Wei W, Coelho CM, Li X, Marek R, Yan S, Anderson S, Meyers D, Mukherjee C, Sbardella G, Castellano S, Milite C, Rotili D, Mai A, Cole PA, Sah P, et al. p300/CBP-associated factor selectively regulates the extinction of conditioned fear. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 11930-41. PMID 22933779 DOI: 10.1523/Jneurosci.0178-12.2012  1
2012 Ferrando IM, Chaerkady R, Zhong J, Molina H, Jacob HK, Herbst-Robinson K, Dancy BM, Katju V, Bose R, Zhang J, Pandey A, Cole PA. Identification of targets of c-Src tyrosine kinase by chemical complementation and phosphoproteomics. Molecular & Cellular Proteomics : McP. 11: 355-69. PMID 22499769 DOI: 10.1074/Mcp.M111.015750  1
2012 Dancy BC, Ming SA, Papazyan R, Jelinek CA, Majumdar A, Sun Y, Dancy BM, Drury WJ, Cotter RJ, Taverna SD, Cole PA. Azalysine analogues as probes for protein lysine deacetylation and demethylation. Journal of the American Chemical Society. 134: 5138-48. PMID 22352831 DOI: 10.1021/Ja209574Z  1
2012 Tarrant MK, Rho HS, Xie Z, Jiang YL, Gross C, Culhane JC, Yan G, Qian J, Ichikawa Y, Matsuoka T, Zachara N, Etzkorn FA, Hart GW, Jeong JS, Blackshaw S, ... ... Cole PA, et al. Regulation of CK2 by phosphorylation and O-GlcNAcylation revealed by semisynthesis. Nature Chemical Biology. 8: 262-9. PMID 22267120 DOI: 10.1038/Nchembio.771  1
2011 Zhang Y, Ahn YH, Benjamin IJ, Honda T, Hicks RJ, Calabrese V, Cole PA, Dinkova-Kostova AT. HSF1-dependent upregulation of Hsp70 by sulfhydryl-reactive inducers of the KEAP1/NRF2/ARE pathway. Chemistry & Biology. 18: 1355-61. PMID 22118669 DOI: 10.1016/J.Chembiol.2011.09.008  1
2011 Wang Z, Longo PA, Tarrant MK, Kim K, Head S, Leahy DJ, Cole PA. Mechanistic insights into the activation of oncogenic forms of EGF receptor. Nature Structural & Molecular Biology. 18: 1388-93. PMID 22101934 DOI: 10.1038/Nsmb.2168  1
2011 Wang L, Gural A, Sun XJ, Zhao X, Perna F, Huang G, Hatlen MA, Vu L, Liu F, Xu H, Asai T, Xu H, Deblasio T, Menendez S, Voza F, ... ... Cole PA, et al. The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation. Science (New York, N.Y.). 333: 765-9. PMID 21764752 DOI: 10.1126/Science.1201662  1
2011 Santer FR, Höschele PP, Oh SJ, Erb HH, Bouchal J, Cavarretta IT, Parson W, Meyers DJ, Cole PA, Culig Z. Inhibition of the acetyltransferases p300 and CBP reveals a targetable function for p300 in the survival and invasion pathways of prostate cancer cell lines. Molecular Cancer Therapeutics. 10: 1644-55. PMID 21709130 DOI: 10.1158/1535-7163.Mct-11-0182  1
2011 Smirnova NA, Haskew-Layton RE, Basso M, Hushpulian DM, Payappilly JB, Speer RE, Ahn YH, Rakhman I, Cole PA, Pinto JT, Ratan RR, Gazaryan IG. Development of Neh2-luciferase reporter and its application for high throughput screening and real-time monitoring of Nrf2 activators. Chemistry & Biology. 18: 752-65. PMID 21700211 DOI: 10.1016/J.Chembiol.2011.03.013  1
2011 Xu CR, Cole PA, Meyers DJ, Kormish J, Dent S, Zaret KS. Chromatin "prepattern" and histone modifiers in a fate choice for liver and pancreas. Science (New York, N.Y.). 332: 963-6. PMID 21596989 DOI: 10.1126/Science.1202845  1
2011 Marek R, Coelho CM, Sullivan RK, Baker-Andresen D, Li X, Ratnu V, Dudley KJ, Meyers D, Mukherjee C, Cole PA, Sah P, Bredy TW. Paradoxical enhancement of fear extinction memory and synaptic plasticity by inhibition of the histone acetyltransferase p300. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 7486-91. PMID 21593332 DOI: 10.1523/Jneurosci.0133-11.2011  1
2011 Crump NT, Hazzalin CA, Bowers EM, Alani RM, Cole PA, Mahadevan LC. Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP. Proceedings of the National Academy of Sciences of the United States of America. 108: 7814-9. PMID 21518915 DOI: 10.1073/Pnas.1100099108  1
2011 Collins SL, Black KE, Chan-Li Y, Ahn YH, Cole PA, Powell JD, Horton MR. Hyaluronan fragments promote inflammation by down-regulating the anti-inflammatory A2a receptor. American Journal of Respiratory Cell and Molecular Biology. 45: 675-83. PMID 21257926 DOI: 10.1165/Rcmb.2010-0387Oc  1
2011 Tang Y, Holbert MA, Delgoshaie N, Wurtele H, Guillemette B, Meeth K, Yuan H, Drogaris P, Lee EH, Durette C, Thibault P, Verreault A, Cole PA, Marmorstein R. Structure of the Rtt109-AcCoA/Vps75 complex and implications for chaperone-mediated histone acetylation. Structure (London, England : 1993). 19: 221-31. PMID 21256037 DOI: 10.1016/J.Str.2010.12.012  1
2011 Karukurichi KR, Cole PA. Probing the reaction coordinate of the p300/CBP histone acetyltransferase with bisubstrate analogs. Bioorganic Chemistry. 39: 42-7. PMID 21111442 DOI: 10.1016/J.Bioorg.2010.10.004  1
2010 Taverna SD, Cole PA. Drug discovery: Reader's block. Nature. 468: 1050-1. PMID 21179160 DOI: 10.1038/4681050A  1
2010 Barnett BP, Hwang Y, Taylor MS, Kirchner H, Pfluger PT, Bernard V, Lin YY, Bowers EM, Mukherjee C, Song WJ, Longo PA, Leahy DJ, Hussain MA, Tschöp MH, Boeke JD, ... Cole PA, et al. Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor. Science (New York, N.Y.). 330: 1689-92. PMID 21097901 DOI: 10.1126/Science.1196154  1
2010 Bellows ML, Taylor MS, Cole PA, Shen L, Siliciano RF, Fung HK, Floudas CA. Discovery of entry inhibitors for HIV-1 via a new de novo protein design framework. Biophysical Journal. 99: 3445-53. PMID 21081094 DOI: 10.1016/J.Bpj.2010.09.050  1
2010 Cerchietti LC, Hatzi K, Caldas-Lopes E, Yang SN, Figueroa ME, Morin RD, Hirst M, Mendez L, Shaknovich R, Cole PA, Bhalla K, Gascoyne RD, Marra M, Chiosis G, Melnick A. BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy. The Journal of Clinical Investigation. 120: 4569-82. PMID 21041953 DOI: 10.1172/Jci42869  1
2010 Min SW, Cho SH, Zhou Y, Schroeder S, Haroutunian V, Seeley WW, Huang EJ, Shen Y, Masliah E, Mukherjee C, Meyers D, Cole PA, Ott M, Gan L. Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron. 67: 953-66. PMID 20869593 DOI: 10.1016/J.Neuron.2010.08.044  1
2010 Reynoird N, Schwartz BE, Delvecchio M, Sadoul K, Meyers D, Mukherjee C, Caron C, Kimura H, Rousseaux S, Cole PA, Panne D, French CA, Khochbin S. Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains. The Embo Journal. 29: 2943-52. PMID 20676058 DOI: 10.1038/Emboj.2010.176  1
2010 Huang R, Holbert MA, Tarrant MK, Curtet S, Colquhoun DR, Dancy BM, Dancy BC, Hwang Y, Tang Y, Meeth K, Marmorstein R, Cole RN, Khochbin S, Cole PA. Site-specific introduction of an acetyl-lysine mimic into peptides and proteins by cysteine alkylation. Journal of the American Chemical Society. 132: 9986-7. PMID 20608637 DOI: 10.1021/Ja103954U  1
2010 Bowers EM, Yan G, Mukherjee C, Orry A, Wang L, Holbert MA, Crump NT, Hazzalin CA, Liszczak G, Yuan H, Larocca C, Saldanha SA, Abagyan R, Sun Y, Meyers DJ, ... ... Cole PA, et al. Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. Chemistry & Biology. 17: 471-82. PMID 20534345 DOI: 10.1016/J.Chembiol.2010.03.006  1
2010 Huang R, Martinez-Ferrando I, Cole PA. Enhanced interrogation: emerging strategies for cell signaling inhibition. Nature Structural & Molecular Biology. 17: 646-9. PMID 20520657 DOI: 10.1038/Nsmb0610-646  1
2010 Ahn YH, Hwang Y, Liu H, Wang XJ, Zhang Y, Stephenson KK, Boronina TN, Cole RN, Dinkova-Kostova AT, Talalay P, Cole PA. Electrophilic tuning of the chemoprotective natural product sulforaphane Proceedings of the National Academy of Sciences of the United States of America. 107: 9590-9595. PMID 20439747 DOI: 10.1073/Pnas.1004104107  1
2010 Culhane JC, Wang D, Yen PM, Cole PA. Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors. Journal of the American Chemical Society. 132: 3164-76. PMID 20148560 DOI: 10.1021/Ja909996P  1
2010 Karukurichi KR, Wang L, Uzasci L, Manlandro CM, Wang Q, Cole PA. Analysis of p300/CBP histone acetyltransferase regulation using circular permutation and semisynthesis. Journal of the American Chemical Society. 132: 1222-3. PMID 20063892 DOI: 10.1021/Ja909466D  1
2009 Szewczuk LM, Tarrant MK, Cole PA. Protein phosphorylation by semisynthesis: from paper to practice. Methods in Enzymology. 462: 1-24. PMID 19632467 DOI: 10.1016/S0076-6879(09)62001-2  1
2009 Qiu C, Tarrant MK, Boronina T, Longo PA, Kavran JM, Cole RN, Cole PA, Leahy DJ. In vitro enzymatic characterization of near full length EGFR in activated and inhibited states. Biochemistry. 48: 6624-32. PMID 19518076 DOI: 10.1021/Bi900755N  1
2009 Tarrant MK, Cole PA. The chemical biology of protein phosphorylation. Annual Review of Biochemistry. 78: 797-825. PMID 19489734 DOI: 10.1146/Annurev.Biochem.78.070907.103047  1
2009 Hansson ML, Popko-Scibor AE, Saint Just Ribeiro M, Dancy BM, Lindberg MJ, Cole PA, Wallberg AE. The transcriptional coactivator MAML1 regulates p300 autoacetylation and HAT activity. Nucleic Acids Research. 37: 2996-3006. PMID 19304754 DOI: 10.1093/Nar/Gkp163  1
2009 Muratore KE, Seeliger MA, Wang Z, Fomina D, Neiswinger J, Havranek JJ, Baker D, Kuriyan J, Cole PA. Comparative analysis of mutant tyrosine kinase chemical rescue. Biochemistry. 48: 3378-86. PMID 19260709 DOI: 10.1021/Bi900057G  1
2009 Wang D, Xia X, Liu Y, Oetting A, Walker RL, Zhu Y, Meltzer P, Cole PA, Shi YB, Yen PM. Negative regulation of TSHalpha target gene by thyroid hormone involves histone acetylation and corepressor complex dissociation. Molecular Endocrinology (Baltimore, Md.). 23: 600-9. PMID 19196836 DOI: 10.1210/Me.2008-0389  1
2008 Wang L, Tang Y, Cole PA, Marmorstein R. Structure and chemistry of the p300/CBP and Rtt109 histone acetyltransferases: implications for histone acetyltransferase evolution and function. Current Opinion in Structural Biology. 18: 741-7. PMID 18845255 DOI: 10.1016/J.Sbi.2008.09.004  1
2008 Cole PA. Chemical probes for histone-modifying enzymes. Nature Chemical Biology. 4: 590-7. PMID 18800048 DOI: 10.1038/Nchembio.111  1
2008 Szewczuk LM, Tarrant MK, Sample V, Drury WJ, Zhang J, Cole PA. Analysis of serotonin N-acetyltransferase regulation in vitro and in live cells using protein semisynthesis. Biochemistry. 47: 10407-19. PMID 18771288 DOI: 10.1021/Bi801189D  1
2008 Levinson NM, Seeliger MA, Cole PA, Kuriyan J. Structural Basis for the Recognition of c-Src by Its Inactivator Csk Cell. 134: 124-134. PMID 18614016 DOI: 10.1016/J.Cell.2008.05.051  1
2008 Tang Y, Holbert MA, Wurtele H, Meeth K, Rocha W, Gharib M, Jiang E, Thibault P, Verreault A, Verrault A, Cole PA, Marmorstein R. Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300/CBP. Nature Structural & Molecular Biology. 15: 738-45. PMID 18568037 DOI: 10.1038/Nsmb.1448  1
2008 Pickin KA, Chaudhury S, Dancy BCR, Gray JJ, Cole PA. Analysis of protein kinase autophosphorylation using expressed protein ligation and computational modeling Journal of the American Chemical Society. 130: 5667-5669. PMID 18396877 DOI: 10.1021/Ja711244H  1
2008 Qiu C, Tarrant MK, Choi SH, Sathyamurthy A, Bose R, Banjade S, Pal A, Bornmann WG, Lemmon MA, Cole PA, Leahy DJ. Mechanism of activation and inhibition of the HER4/ErbB4 kinase. Structure (London, England : 1993). 16: 460-7. PMID 18334220 DOI: 10.1016/J.Str.2007.12.016  1
2008 Liu X, Wang L, Zhao K, Thompson PR, Hwang Y, Marmorstein R, Cole PA. The structural basis of protein acetylation by the p300/CBP transcriptional coactivator. Nature. 451: 846-50. PMID 18273021 DOI: 10.1038/Nature06546  1
2008 Mathivanan S, Ahmed M, Ahn NG, Alexandre H, Amanchy R, Andrews PC, Bader JS, Balgley BM, Bantscheff M, Bennett KL, Björling E, Blagoev B, Bose R, Brahmachari SK, Burlingame AS, ... ... Cole PA, et al. Human Proteinpedia enables sharing of human protein data. Nature Biotechnology. 26: 164-7. PMID 18259167 DOI: 10.1038/Nbt0208-164  1
2008 Tang Y, Holbert MA, Wurtele H, Meeth K, Rocha W, Gharib M, Jiang E, Thibault P, Verreault A, Cole PA, Marmorstein R. Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300/CBP (Nature Structural and Molecular Biology (2008) 15, (738-745)) Nature Structural and Molecular Biology. 15: 998. DOI: 10.1038/Nsmb0908-998D  1
2008 Cole PA. Reverse Chemical Genetics Revisited: Chemical Biology and Enzymology: Protein Phosphorylation as a Case Study Chemical Biology: From Small Molecules to Systems Biology and Drug Design, Volume 1-3. 1: 385-402. DOI: 10.1002/9783527619375.ch7b  1
2007 Zhang X, Pickin KA, Bose R, Jura N, Cole PA, Kuriyan J. Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface. Nature. 450: 741-4. PMID 18046415 DOI: 10.1038/Nature05998  1
2007 Szewczuk LM, Saldanha SA, Ganguly S, Bowers EM, Javoroncov M, Karanam B, Culhane JC, Holbert MA, Klein DC, Abagyan R, Cole PA. De novo discovery of serotonin N-acetyltransferase inhibitors. Journal of Medicinal Chemistry. 50: 5330-8. PMID 17924613 DOI: 10.1021/Jm0706463  1
2007 Culhane JC, Cole PA. LSD1 and the chemistry of histone demethylation. Current Opinion in Chemical Biology. 11: 561-8. PMID 17851108 DOI: 10.1016/J.Cbpa.2007.07.014  1
2007 Hwang Y, Thompson PR, Wang L, Jiang L, Kelleher NL, Cole PA. A selective chemical probe for coenzyme A-requiring enzymes. Angewandte Chemie (International Ed. in English). 46: 7621-4. PMID 17768748 DOI: 10.1002/Anie.200702485  1
2007 Hu X, Dang Y, Tenney K, Crews P, Tsai CW, Sixt KM, Cole PA, Liu JO. Regulation of c-Src Nonreceptor Tyrosine Kinase Activity by Bengamide A through Inhibition of Methionine Aminopeptidases Chemistry and Biology. 14: 764-774. PMID 17656313 DOI: 10.1016/J.Chembiol.2007.05.010  1
2007 Muratore KE, Cole PA. A lock on phosphotyrosine signaling. Acs Chemical Biology. 2: 454-6. PMID 17649969 DOI: 10.1021/Cb7001285  1
2007 Karanam B, Wang L, Wang D, Liu X, Marmorstein R, Cotter R, Cole PA. Multiple roles for acetylation in the interaction of p300 HAT with ATF-2. Biochemistry. 46: 8207-16. PMID 17590016 DOI: 10.1021/Bi7000054  1
2007 Yang M, Culhane JC, Szewczuk LM, Jalili P, Ball HL, Machius M, Cole PA, Yu H. Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine. Biochemistry. 46: 8058-65. PMID 17569509 DOI: 10.1021/Bi700664Y  1
2007 Yang M, Culhane JC, Szewczuk LM, Gocke CB, Brautigam CA, Tomchick DR, Machius M, Cole PA, Yu H. Structural basis of histone demethylation by LSD1 revealed by suicide inactivation. Nature Structural & Molecular Biology. 14: 535-9. PMID 17529991 DOI: 10.1038/Nsmb1255  1
2007 Szewczuk LM, Culhane JC, Yang M, Majumdar A, Yu H, Cole PA. Mechanistic analysis of a suicide inactivator of histone demethylase LSD1. Biochemistry. 46: 6892-902. PMID 17511474 DOI: 10.1021/Bi700414B  1
2007 Hwang Y, Ganguly S, Ho AK, Klein DC, Cole PA. Enzymatic and cellular study of a serotonin N-acetyltransferase phosphopantetheine-based prodrug. Bioorganic & Medicinal Chemistry. 15: 2147-55. PMID 17258461 DOI: 10.1016/J.Bmc.2006.12.016  1
2006 Bose R, Holbert MA, Pickin KA, Cole PA. Protein tyrosine kinase-substrate interactions. Current Opinion in Structural Biology. 16: 668-75. PMID 17085043 DOI: 10.1016/J.Sbi.2006.10.012  1
2006 Karanam B, Jiang L, Wang L, Kelleher NL, Cole PA. Kinetic and mass spectrometric analysis of p300 histone acetyltransferase domain autoacetylation. The Journal of Biological Chemistry. 281: 40292-301. PMID 17065153 DOI: 10.1074/Jbc.M608813200  1
2006 Bose R, Molina H, Patterson AS, Bitok JK, Periaswamy B, Bader JS, Pandey A, Cole PA. Phosphoproteomic analysis of Her2/neu signaling and inhibition. Proceedings of the National Academy of Sciences of the United States of America. 103: 9773-8. PMID 16785428 DOI: 10.1073/Pnas.0603948103  1
2006 Zhang X, Gureasko J, Shen K, Cole PA, Kuriyan J. An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor Cell. 125: 1137-1149. PMID 16777603 DOI: 10.1016/J.Cell.2006.05.013  1
2006 Cheng KY, Noble ME, Skamnaki V, Brown NR, Lowe ED, Kontogiannis L, Shen K, Cole PA, Siligardi G, Johnson LN. The role of the phospho-CDK2/cyclin A recruitment site in substrate recognition. The Journal of Biological Chemistry. 281: 23167-79. PMID 16707497 DOI: 10.1074/Jbc.M600480200  1
2006 Levinson NM, Kuchment O, Shen K, Young MA, Koldobskiy M, Karplus M, Cole PA, Kuriyan J. A Src-like inactive conformation in the abl tyrosine kinase domain. Plos Biology. 4: e144. PMID 16640460 DOI: 10.1371/Journal.Pbio.0040144  1
2006 Culhane JC, Szewczuk LM, Liu X, Da G, Marmorstein R, Cole PA. A mechanism-based inactivator for histone demethylase LSD1. Journal of the American Chemical Society. 128: 4536-7. PMID 16594666 DOI: 10.1021/Ja0602748  1
2006 Schwarzer D, Zhang Z, Zheng W, Cole PA. Negative regulation of a protein tyrosine phosphatase by tyrosine phosphorylation. Journal of the American Chemical Society. 128: 4192-3. PMID 16568970 DOI: 10.1021/Ja0585174  1
2006 Qiao Y, Molina H, Pandey A, Zhang J, Cole PA. Chemical rescue of a mutant enzyme in living cells. Science (New York, N.Y.). 311: 1293-7. PMID 16513984 DOI: 10.1126/Science.1122224  1
2005 Lewczuk B, Zheng W, Prusik M, Cole PA, Przybylska-Gornowicz B. N-bromoacetyltryptamine strongly and reversibly inhibits in vitro melatonin secretion from mammalian pinealocytes. Neuro Endocrinology Letters. 26: 581-92. PMID 16264397  0.4
2005 Schwarzer D, Cole PA. Protein semisynthesis and expressed protein ligation: chasing a protein's tail. Current Opinion in Chemical Biology. 9: 561-9. PMID 16226484 DOI: 10.1016/J.Cbpa.2005.09.018  1
2005 Shen K, Hines AC, Schwarzer D, Pickin KA, Cole PA. Protein kinase structure and function analysis with chemical tools. Biochimica Et Biophysica Acta. 1754: 65-78. PMID 16213197 DOI: 10.1016/J.Bbapap.2005.08.020  1
2005 Zheng Y, Mamdani F, Toptygin D, Brand L, Stivers JT, Cole PA. Fluorescence analysis of a dynamic loop in the PCAF/GCN5 histone acetyltransferase. Biochemistry. 44: 10501-9. PMID 16060659 DOI: 10.1021/Bi050776I  1
2005 Hines AC, Parang K, Kohanski RA, Hubbard SR, Cole PA. Bisubstrate analog probes for the insulin receptor protein tyrosine kinase: molecular yardsticks for analyzing catalytic mechanism and inhibitor design. Bioorganic Chemistry. 33: 285-97. PMID 16023488 DOI: 10.1016/J.Bioorg.2005.02.002  1
2005 Cleary J, Sitwala KV, Khodadoust MS, Kwok RP, Mor-Vaknin N, Cebrat M, Cole PA, Markovitz DM. p300/CBP-associated factor drives DEK into interchromatin granule clusters. The Journal of Biological Chemistry. 280: 31760-7. PMID 15987677 DOI: 10.1074/Jbc.M500884200  1
2005 Guidez F, Howell L, Isalan M, Cebrat M, Alani RM, Ivins S, Hormaeche I, McConnell MJ, Pierce S, Cole PA, Licht J, Zelent A. Histone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein. Molecular and Cellular Biology. 25: 5552-66. PMID 15964811 DOI: 10.1182/Blood.V104.11.359.359  1
2005 Wang D, Thompson P, Cole PA, Cotter RJ. Structural analysis of a highly acetylated protein using a curved-field reflectron mass spectrometer. Proteomics. 5: 2288-96. PMID 15887180 DOI: 10.1002/Pmic.200401167  1
2005 Cheung E, Acevedo ML, Cole PA, Kraus WL. Altered pharmacology and distinct coactivator usage for estrogen receptor-dependent transcription through activating protein-1. Proceedings of the National Academy of Sciences of the United States of America. 102: 559-64. PMID 15642950 DOI: 10.1073/Pnas.0407113102  1
2005 Zheng W, Schwarzer D, Lebeau A, Weller JL, Klein DC, Cole PA. Cellular stability of serotonin N-acetyltransferase conferred by phosphonodifluoromethylene alanine (Pfa) substitution for Ser-205. The Journal of Biological Chemistry. 280: 10462-7. PMID 15632116 DOI: 10.1074/Jbc.M412283200  1
2005 Yoon HG, Choi Y, Cole PA, Wong J. Reading and function of a histone code involved in targeting corepressor complexes for repression. Molecular and Cellular Biology. 25: 324-35. PMID 15601853 DOI: 10.1128/Mcb.25.1.324-335.2005  1
2004 Shi Y, Lan F, Matson C, Mulligan P, Whetstine JR, Cole PA, Casero RA, Shi Y. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell. 119: 941-53. PMID 15620353 DOI: 10.1016/j.cell.2004.12.012  1
2004 Sagar V, Zheng W, Thompson PR, Cole PA. Bisubstrate analogue structure-activity relationships for p300 histone acetyltransferase inhibitors. Bioorganic & Medicinal Chemistry. 12: 3383-90. PMID 15158807 DOI: 10.1016/J.Bmc.2004.03.070  1
2004 Hwang Y, Cole PA. Efficient synthesis of phosphorylated prodrugs with bis(POM)-phosphoryl chloride. Organic Letters. 6: 1555-6. PMID 15128234 DOI: 10.1021/Ol049714V  1
2004 Hines AC, Cole PA. Design, synthesis, and characterization of an ATP-peptide conjugate inhibitor of protein kinase A. Bioorganic & Medicinal Chemistry Letters. 14: 2951-4. PMID 15125966 DOI: 10.1016/J.Bmcl.2004.03.039  1
2004 Farrell CJ, Lee JM, Shin EC, Cebrat M, Cole PA, Hayward SD. Inhibition of Epstein-Barr virus-induced growth proliferation by a nuclear antigen EBNA2-TAT peptide. Proceedings of the National Academy of Sciences of the United States of America. 101: 4625-30. PMID 15070768 DOI: 10.1073/Pnas.0306482101  1
2004 Thompson PR, Wang D, Wang L, Fulco M, Pediconi N, Zhang D, An W, Ge Q, Roeder RG, Wong J, Levrero M, Sartorelli V, Cotter RJ, Cole PA. Regulation of the p300 HAT domain via a novel activation loop. Nature Structural & Molecular Biology. 11: 308-15. PMID 15004546 DOI: 10.1038/Nsmb740  0.92
2004 Zheng Y, Thompson PR, Cebrat M, Wang L, Devlin MK, Alani RM, Cole PA. Selective HAT inhibitors as mechanistic tools for protein acetylation. Methods in Enzymology. 376: 188-99. PMID 14975306 DOI: 10.1016/S0076-6879(03)76012-1  0.8
2003 Shen K, Cole PA. Conversion of a tyrosine kinase protein substrate to a high affinity ligand by ATP linkage. Journal of the American Chemical Society. 125: 16172-3. PMID 14692742 DOI: 10.1021/Ja0380401  1
2003 Cole PA, Shen K, Qiao Y, Wang D. Protein tyrosine kinases Src and Csk: a tail's tale. Current Opinion in Chemical Biology. 7: 580-5. PMID 14580561 DOI: 10.1016/J.Cbpa.2003.08.009  1
2003 Zheng W, Zhang Z, Ganguly S, Weller JL, Klein DC, Cole PA. Cellular stabilization of the melatonin rhythm enzyme induced by nonhydrolyzable phosphonate incorporation. Nature Structural Biology. 10: 1054-7. PMID 14578935 DOI: 10.1038/Nsb1005  1
2003 Zheng W, Cole PA. Novel bisubstrate analog inhibitors of serotonin N-acetyltransferase: the importance of being neutral. Bioorganic Chemistry. 31: 398-411. PMID 12941292 DOI: 10.1016/S0045-2068(03)00081-6  1
2003 Kaehlcke K, Dorr A, Hetzer-Egger C, Kiermer V, Henklein P, Schnoelzer M, Loret E, Cole PA, Verdin E, Ott M. Acetylation of Tat defines a cyclinT1-independent step in HIV transactivation. Molecular Cell. 12: 167-76. PMID 12887902 DOI: 10.1016/S1097-2765(03)00245-4  1
2003 Cebrat M, Kim CM, Thompson PR, Daugherty M, Cole PA. Synthesis and analysis of potential prodrugs of coenzyme A analogues for the inhibition of the histone acetyltransferase p300. Bioorganic & Medicinal Chemistry. 11: 3307-13. PMID 12837541 DOI: 10.1016/S0968-0896(03)00265-7  1
2003 Cole PA, Courtney AD, Shen K, Zhang Z, Qiao Y, Lu W, Williams DM. Chemical approaches to reversible protein phosphorylation. Accounts of Chemical Research. 36: 444-52. PMID 12809531 DOI: 10.1021/Ar0201254  0.64
2003 Scheibner KA, Zhang Z, Cole PA. Merging fluorescence resonance energy transfer and expressed protein ligation to analyze protein-protein interactions. Analytical Biochemistry. 317: 226-32. PMID 12758261 DOI: 10.1016/S0003-2697(03)00087-3  1
2003 Lu W, Shen K, Cole PA. Chemical dissection of the effects of tyrosine phosphorylation of SHP-2. Biochemistry. 42: 5461-8. PMID 12731888 DOI: 10.1021/Bi0340144  1
2003 Huang ZQ, Li J, Sachs LM, Cole PA, Wong J. A role for cofactor-cofactor and cofactor-histone interactions in targeting p300, SWI/SNF and Mediator for transcription. The Embo Journal. 22: 2146-55. PMID 12727881 DOI: 10.1093/Emboj/Cdg219  1
2003 Georges SA, Giebler HA, Cole PA, Luger K, Laybourn PJ, Nyborg JK. Tax recruitment of CBP/p300, via the KIX domain, reveals a potent requirement for acetyltransferase activity that is chromatin dependent and histone tail independent Molecular and Cellular Biology. 23: 3392-3404. PMID 12724399 DOI: 10.1128/Mcb.23.10.3392-3404.2003  1
2003 Zhang Z, Shen K, Lu W, Cole PA. The role of C-terminal tyrosine phosphorylation in the regulation of SHP-1 explored via expressed protein ligation. The Journal of Biological Chemistry. 278: 4668-74. PMID 12468540 DOI: 10.1074/Jbc.M210028200  1
2002 Bandyopadhyay D, Okan NA, Bales E, Nascimento L, Cole PA, Medrano EE. Down-regulation of p300/CBP histone acetyltransferase activates a senescence checkpoint in human melanocytes. Cancer Research. 62: 6231-9. PMID 12414652  1
2002 Poux AN, Cebrat M, Kim CM, Cole PA, Marmorstein R. Structure of the GCN5 histone acetyltransferase bound to a bisubstrate inhibitor. Proceedings of the National Academy of Sciences of the United States of America. 99: 14065-70. PMID 12391296 DOI: 10.1073/Pnas.222373899  1
2002 Parang K, Cole PA. Designing bisubstrate analog inhibitors for protein kinases. Pharmacology & Therapeutics. 93: 145-57. PMID 12191607 DOI: 10.1016/S0163-7258(02)00184-5  1
2002 Wang D, Esselman WJ, Cole PA. Substrate conformational restriction and CD45-catalyzed dephosphorylation of tail tyrosine-phosphorylated Src protein. The Journal of Biological Chemistry. 277: 40428-33. PMID 12181320 DOI: 10.1074/Jbc.M206467200  1
2002 Lowry WE, Huang J, Ma YC, Ali S, Wang D, Williams DM, Okada M, Cole PA, Huang XY. Csk, a critical link of g protein signals to actin cytoskeletal reorganization. Developmental Cell. 2: 733-44. PMID 12062086 DOI: 10.1016/S1534-5807(02)00175-2  1
2002 Zheng W, Cole PA. Serotonin N-acetyltransferase: Mechanism and inhibition Current Medicinal Chemistry. 9: 1187-1199. PMID 12052171 DOI: 10.2174/0929867023370013  1
2002 Parang K, Kohn JA, Saldanha SA, Cole PA. Development of photo-crosslinking reagents for protein kinase-substrate interactions. Febs Letters. 520: 156-60. PMID 12044889 DOI: 10.1016/S0014-5793(02)02778-3  1
2002 Williams DM, Cole PA. Proton demand inversion in a mutant protein tyrosine kinase reaction Journal of the American Chemical Society. 124: 5956-5957. PMID 12022825 DOI: 10.1021/Ja025993A  1
2002 Subbaramaiah K, Cole PA, Dannenberg AJ. Retinoids and carnosol suppress cyclooxygenase-2 transcription by CREB-binding protein/p300-dependent and -independent mechanisms Cancer Research. 62: 2522-2530. PMID 11980644  1
2002 Wolf E, De Angelis J, Khalil EM, Cole PA, Burley SK. X-ray crystallographic studies of serotonin N-acetyltransferase catalysis and inhibition Journal of Molecular Biology. 317: 215-224. PMID 11902838 DOI: 10.1006/Jmbi.2001.5371  1
2002 Scheibner KA, De Angelis J, Burley SK, Cole PA. Investigation of the roles of catalytic residues in serotonin N-acetyltransferase. The Journal of Biological Chemistry. 277: 18118-26. PMID 11884405 DOI: 10.1074/Jbc.M200595200  1
2001 Shekhtman A, Ghose R, Wang D, Cole PA, Cowburn D. Novel mechanism of regulation of the non-receptor protein tyrosine kinase Csk: insights from NMR mapping studies and site-directed mutagenesis. Journal of Molecular Biology. 314: 129-38. PMID 11724538 DOI: 10.1006/Jmbi.2001.5126  1
2001 Asahara H, Santoso B, Guzman E, Du K, Cole PA, Davidson I, Montminy M. Chromatin-dependent cooperativity between constitutive and inducible activation domains in CREB. Molecular and Cellular Biology. 21: 7892-900. PMID 11689682 DOI: 10.1128/Mcb.21.23.7892-7900.2001  1
2001 Lu W, Gong D, Bar-Sagi D, Cole PA. Site-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signaling Molecular Cell. 8: 759-769. PMID 11684012 DOI: 10.1016/S1097-2765(01)00369-0  1
2001 Wang D, Cole PA. Protein tyrosine kinase Csk-catalyzed phosphorylation of Src containing unnatural tyrosine analogues Journal of the American Chemical Society. 123: 8883-8886. PMID 11552794 DOI: 10.1021/Ja010540B  1
2001 Thompson PR, Cole PA. Probing the mechanism of enzymatic phosphoryl transfer with a chemical trick Proceedings of the National Academy of Sciences of the United States of America. 98: 8170-8171. PMID 11459948 DOI: 10.1073/Pnas.161273998  1
2001 Cheol Min Kim, Cole PA. Bisubstrate ketone analogues as serotonin N-acetyltransferase inhibitors Journal of Medicinal Chemistry. 44: 2479-2485. PMID 11448230 DOI: 10.1021/Jm010049V  1
2001 Thompson PR, Kurooka H, Nakatani Y, Cole PA. Transcriptional coactivator protein p300. Kinetic characterization of its histone acetyltransferase activity. The Journal of Biological Chemistry. 276: 33721-9. PMID 11445580 DOI: 10.1074/Jbc.M104736200  1
2001 Williams DM, Cole PA. Kinase chips hit the proteomics era Trends in Biochemical Sciences. 26: 271-273. PMID 11343910 DOI: 10.1016/S0968-0004(01)01845-X  1
2001 Wang D, Huang XY, Cole PA. Molecular determinants for Csk-catalyzed tyrosine phosphorylation of the Src tail Biochemistry. 40: 2004-2010. PMID 11329267 DOI: 10.1021/Bi002342N  1
2001 Zheng W, Scheibner KA, Ho AK, Cole PA. Mechanistic studies on the alkyltransferase activity of serotonin N-acetyltransferase. Chemistry & Biology. 8: 379-89. PMID 11325593 DOI: 10.1016/S1074-5521(01)00020-5  1
2001 Parang K, Till JH, Ablooglu AJ, Kohanski RA, Hubbard SR, Cole PA. Mechanism-based design of a protein kinase inhibitor. Nature Structural Biology. 8: 37-41. PMID 11135668 DOI: 10.1038/83028  1
2000 Kundu TK, Palhan VB, Wang Z, An W, Cole PA, Roeder RG. Activator-dependent transcription from chromatin in vitro involving targeted histone acetylation by p300. Molecular Cell. 6: 551-61. PMID 11030335 DOI: 10.1016/S1097-2765(00)00054-X  0.64
2000 Williams DM, Wang D, Cole PA. Chemical rescue of a mutant protein-tyrosine kinase Journal of Biological Chemistry. 275: 38127-38130. PMID 11006267 DOI: 10.1074/Jbc.C000606200  1
2000 Kim K, Parang K, Lau OD, Cole PA. Tyrosine analogues as alternative substrates for protein tyrosine kinase Csk: Insights into substrate selectivity and catalytic mechanism Bioorganic and Medicinal Chemistry. 8: 1263-1268. PMID 10896106 DOI: 10.1016/S0968-0896(00)00053-5  1
2000 Lau OD, Kundu TK, Soccio RE, Ait-Si-Ali S, Khalil EM, Vassilev A, Wolffe AP, Nakatani Y, Roeder RG, Cole PA. HATs off: Selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF Molecular Cell. 5: 589-595. PMID 10882143 DOI: 10.1016/S1097-2765(00)80452-9  1
2000 Ablooglu AJ, Till JH, Kim K, Parang K, Cole PA, Hubbard SR, Kohanski RA. Probing the catalytic mechanism of the insulin receptor kinase with a tetrafluorotyrosine-containing peptide substrate. The Journal of Biological Chemistry. 275: 30394-8. PMID 10869355 DOI: 10.1074/Jbc.M003524200  1
2000 Lau OD, Courtney AD, Vassilev A, Marzilli LA, Cotter RJ, Nakatani Y, Cole PA. p300/CBP-associated factor histone acetyltransferase processing of a peptide substrate. Kinetic analysis of the catalytic mechanism. The Journal of Biological Chemistry. 275: 21953-9. PMID 10777508 DOI: 10.1074/Jbc.M003219200  1
2000 Blaustein RO, Cole PA, Williams C, Miller C. Tethered blockers as molecular 'tape measures' for a voltage-gated K+ channel. Nature Structural Biology. 7: 309-11. PMID 10742176 DOI: 10.1038/74076  1
1999 Khalil EM, De Angelis J, Ishii M, Cole PA. Mechanism-based inhibition of the melatonin rhythm enzyme: Pharmacologic exploitation of active site functional plasticity Proceedings of the National Academy of Sciences of the United States of America. 96: 12418-12423. PMID 10535937 DOI: 10.1073/Pnas.96.22.12418  1
1999 Sondhi D, Cole PA. Domain interactions in protein tyrosine kinase Csk Biochemistry. 38: 11147-11155. PMID 10460171 DOI: 10.1021/Bi990827+  1
1999 Cole PA, Sondhi D, Kim K. Chemical approaches to the study of protein tyrosine kinases and their implications for mechanism and inhibitor design Pharmacology and Therapeutics. 82: 219-229. PMID 10454199 DOI: 10.1016/S0163-7258(98)00046-1  1
1999 Kyonghee K, Cole PA. Synthesis of (2S,3R)-β-methyltyrosine catalyzed by tyrosine phenol- lyase Bioorganic and Medicinal Chemistry Letters. 9: 1205-1208. PMID 10328314 DOI: 10.1016/S0960-894X(99)00162-6  1
1998 Khalil EM, De Angelis J, Cole PA. Indoleamine analogs as probes of the substrate selectivity and catalytic mechanism of serotonin N-acetyltransferase Journal of Biological Chemistry. 273: 30321-30327. PMID 9804794 DOI: 10.1074/Jbc.273.46.30321  1
1998 Muir TW, Sondhi D, Cole PA. Expressed protein ligation: a general method for protein engineering. Proceedings of the National Academy of Sciences of the United States of America. 95: 6705-10. PMID 9618476 DOI: 10.1073/Pnas.95.12.6705  1
1998 De Angelis J, Gastel J, Klein DC, Cole PA. Kinetic analysis of the catalytic mechanism of serotonin N-acetyltransferase (EC The Journal of Biological Chemistry. 273: 3045-50. PMID 9446620 DOI: 10.1074/Jbc.273.5.3045  1
1998 Sondhi D, Xu W, Songyang Z, Eck MJ, Cole PA. Peptide and protein phosphorylation by protein tyrosine kinase Csk: insights into specificity and mechanism. Biochemistry. 37: 165-72. PMID 9425036 DOI: 10.1021/Bi9722960  1
1998 Khalil EM, Cole PA. A potent inhibitor of the melatonin rhythm enzyme Journal of the American Chemical Society. 120: 6195-6196. DOI: 10.1021/Ja981365A  1
1998 Kim K, Cole PA. Kinetic analysis of a protein tyrosine kinase reaction transition state in the forward and reverse directions Journal of the American Chemical Society. 120: 6851-6858. DOI: 10.1021/Ja9808393  1
1997 Grace MR, Walsh CT, Cole PA. Divalent ion effects and insights into the catalytic mechanism of protein tyrosine kinase Csk. Biochemistry. 36: 1874-81. PMID 9048573 DOI: 10.1021/Bi962138T  1
1997 Kim K, Cole PA. Measurement of a Bronsted nucleophile coefficient and insights into the transition state for a protein tyrosine kinase Journal of the American Chemical Society. 119: 11096-11097. DOI: 10.1021/Ja972110K  1
1996 Cole PA. Chaperone-assisted protein expression Structure. 4: 239-242. PMID 8805540 DOI: 10.1016/S0969-2126(96)00028-7  1
1996 Robinson TL, Cole PA, Kellum GD. Computer Information Retrieval Systems as a Clinical Tool American Journal of Speech-Language Pathology. 5: 24-30.  0.52
1995 Cole PA, Grace MR, Phillips RS, Burn P, Walsh CT. The role of the catalytic base in the protein tyrosine kinase Csk. The Journal of Biological Chemistry. 270: 22105-8. PMID 7673185 DOI: 10.1074/Jbc.270.38.22105  1
1994 Cole PA, Burn P, Takacs B, Walsh CT. Evaluation of the catalytic mechanism of recombinant human Csk (C-terminal Src kinase) using nucleotide analogs and viscosity effects Journal of Biological Chemistry. 269: 30880-30887. PMID 7527038  1
1993 Jaworski K, Cole PA, Robinson CH. Synthetic and Enzymatic Studies with Potential Alternate Substrates for Human Placental Aromatase: 10β-Trifluoroacetyl and 10β-allyl Steroids Bioorganic Chemistry. 21: 330-341. DOI: 10.1006/Bioo.1993.1028  1
1991 Cole PA, Robinson CH. Mechanistic Studies on a Placental Aromatase Model Reaction Journal of the American Chemical Society. 113: 8130-8137. DOI: 10.1021/Ja00021A044  1
1990 Cole PA, Robinson CH. Conversion of 19-oxo[2β-2H]androgens into oestrogens by human placental aromatase. An unexpected stereochemical outcome Biochemical Journal. 268: 553-561. PMID 2363692  1
1990 Cole PA, Bean JM, Robinson CH. Conversion of a 3-desoxysteroid to 3-desoxyestrogen by human placental aromatase. Proceedings of the National Academy of Sciences of the United States of America. 87: 2999-3003. PMID 2326261 DOI: 10.1073/Pnas.87.8.2999  1
1990 Cole PA, Robinson CH. Mechanism and inhibition of cytochrome P-450 aromatase Journal of Medicinal Chemistry. 33: 2933-2942. PMID 2231592 DOI: 10.1021/Jm00173A001  1
1990 Cole PA, Robinson CH. Synthesis of and reactivity studies with 19-peroxide-androstenedione derivatives: Analogues of a proposed aromatase intermediate Journal of the Chemical Society, Perkin Transactions 1. 2119-2125. DOI: 10.1039/P19900002119  1
1990 Grgurina I, Handa S, Weaver G, Cole PA, Battersby AR. Biosynthesis of vitamin B12: Does 51-norcobyrinic acid or 151-norcobyrinic acid act as a precursor of cobyrinic acid? Journal of the Chemical Society, Chemical Communications. 1514-1516. DOI: 10.1039/C39900001514  1
1988 Cole PA, Robinson CH. A peroxide model reaction for placental aromatase Journal of the American Chemical Society. 110: 1284-1285. DOI: 10.1021/Ja00212A043  1
1986 Cole PA, Robinson CH. Synthesis and study of a methoxyhydroperoxide-androstenedione derivative; analogue of a potential aromatase intermediate Journal of the Chemical Society, Chemical Communications. 1651-1653. DOI: 10.1039/C39860001651  1
1979 Kurzweg FT, Cole PA. Triplication of the gallbladder: Review of literature and report of a case American Surgeon. 45: 410-412. PMID 453735  0.68
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