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Frederick Khachik - Publications

Affiliations: 
Chemistry University of Maryland, College Park, College Park, MD 
Area:
Organic Chemistry, Analytical Chemistry
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69 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Bernstein PS, Khachik F, Frank HA. Highlights of carotenoid research from the 17th International Carotenoid Symposium. Archives of Biochemistry and Biophysics. 572: 1. PMID 25817377 DOI: 10.1016/j.abb.2015.03.016  0.32
2014 Crawford K, Mazzola E, Khachik F. Total synthesis of 1,2,5,6-tetrahydro-2,6-cyclo-γ-carotene-1,5-diol, an oxidation product of γ-carotene Synthesis (Germany). 46: 635-645. DOI: 10.1055/s-0033-1340555  0.32
2012 Khachik F. Partial synthesis of serum carotenoids and their metabolites. Acta Biochimica Polonica. 59: 75-8. PMID 22428147  0.32
2012 Khachik F. Synthesis of (3 R,3 R)-zeaxanthin and its meso -stereoisomer from (3 R,3 R,6 R)-lutein via (3 R)-3,4-anhydrolutein Synthesis. 44: 453-459. DOI: 10.1055/s-0031-1289662  0.32
2011 Khachik F, Chang AN. Synthesis of (3S)- and (3R)-3-hydroxy-β-ionone and their transformation into (3S)- and (3R)-β- cryptoxanthin Synthesis. 509-516. DOI: 10.1055/s-0030-1258382  0.32
2011 Khachik F. Industrially viable processes for synthesis of biologically active hydroxycarotenoids commonly found in fruits and vegetables Journal of Food Composition and Analysis. 24: 826-829. DOI: 10.1016/j.jfca.2011.02.005  0.32
2009 Khachik F, Chang AN. Total synthesis of (3R,3'R,6'R)-lutein and its stereoisomers. The Journal of Organic Chemistry. 74: 3875-85. PMID 19391613 DOI: 10.1021/jo900432r  0.32
2007 Sahin K, Ozercan R, Onderci M, Sahin N, Khachik F, Seren S, Kucuk O. Dietary tomato powder supplementation in the prevention of leiomyoma of the oviduct in the Japanese quail. Nutrition and Cancer. 59: 70-5. PMID 17927504 DOI: 10.1080/01635580701365076  0.32
2007 Khachik F, Chang AN, Gana A, Mazzola E. Partial synthesis of (3R,6'R)-alpha-cryptoxanthin and (3R)-beta-cryptoxanthin from (3R,3'R,6'R)-lutein. Journal of Natural Products. 70: 220-6. PMID 17266370 DOI: 10.1021/np060575v  0.32
2006 Khachik F, London E, de Moura FF, Johnson M, Steidl S, Detolla L, Shipley S, Sanchez R, Chen XQ, Flaws J, Lutty G, McLeod S, Fowler B. Chronic ingestion of (3R,3'R,6'R)-lutein and (3R,3'R)-zeaxanthin in the female rhesus macaque. Investigative Ophthalmology & Visual Science. 47: 5476-86. PMID 17122139 DOI: 10.1167/iovs.06-0194  0.32
2006 Khachik F, de Moura FF, Chew EY, Douglass LW, Ferris FL, Kim J, Thompson DJ. The effect of lutein and zeaxanthin supplementation on metabolites of these carotenoids in the serum of persons aged 60 or older. Investigative Ophthalmology & Visual Science. 47: 5234-42. PMID 17122108 DOI: 10.1167/iovs.06-0504  0.32
2006 Rosenthal JM, Kim J, de Monasterio F, de Monastario F, Thompson DJ, Bone RA, Landrum JT, de Moura FF, Khachik F, Chen H, Schleicher RL, Ferris FL, Chew EY. Dose-ranging study of lutein supplementation in persons aged 60 years or older. Investigative Ophthalmology & Visual Science. 47: 5227-33. PMID 17122107 DOI: 10.1167/iovs.05-1513  0.32
2006 Khachik F. Distribution and metabolism of dietary carotenoids in humans as a criterion for development of nutritional supplements Pure and Applied Chemistry. 78: 1551-1557. DOI: 10.1351/pac200678081551  0.32
2006 Sahin K, Onderci M, Sahin N, Gursu MF, Khachik F, Kucuk O. Effects of lycopene supplementation on antioxidant status, oxidative stress, performance and carcass characteristics in heat-stressed Japanese quail Journal of Thermal Biology. 31: 307-312. DOI: 10.1016/j.jtherbio.2005.12.006  0.32
2004 Sahin K, Ozercan R, Onderci M, Sahin N, Gursu MF, Khachik F, Sarkar FH, Munkarah A, Ali-Fehmi R, Kmak D, Kucuk O. Lycopene supplementation prevents the development of spontaneous smooth muscle tumors of the oviduct in Japanese quail. Nutrition and Cancer. 50: 181-9. PMID 15623465 DOI: 10.1207/s15327914nc5002_8  0.32
2003 Gann PH, Khachik F. Tomatoes or lycopene versus prostate cancer: is evolution anti-reductionist? Journal of the National Cancer Institute. 95: 1563-5. PMID 14600081  0.32
2003 Blakely S, Herbert A, Collins M, Jenkins M, Mitchell G, Grundel E, O'Neill KR, Khachik F. Lutein interacts with ascorbic acid more frequently than with alpha-tocopherol to alter biomarkers of oxidative stress in female zucker obese rats. The Journal of Nutrition. 133: 2838-44. PMID 12949374  0.32
2003 Humphries JM, Khachik F. Distribution of lutein, zeaxanthin, and related geometrical isomers in fruit, vegetables, wheat, and pasta products. Journal of Agricultural and Food Chemistry. 51: 1322-7. PMID 12590476 DOI: 10.1021/jf026073e  0.32
2003 Khachik F. An efficient conversion of (3R,3'R,6'R)-lutein to (3R,3'S,6'R)-lutein (3'-epilutein) and (3R,3'R)-zeaxanthin. Journal of Natural Products. 66: 67-72. PMID 12542348 DOI: 10.1021/np020376l  0.32
2002 Kucuk O, Sarkar FH, Djuric Z, Sakr W, Pollak MN, Khachik F, Banerjee M, Bertram JS, Wood DP. Effects of lycopene supplementation in patients with localized prostate cancer Experimental Biology and Medicine. 227: 881-885. PMID 12424329 DOI: 10.1177/153537020222701007  0.32
2002 Khachik F, Carvalho L, Bernstein PS, Muir GJ, Zhao DY, Katz NB. Chemistry, distribution, and metabolism of tomato carotenoids and their impact on human health. Experimental Biology and Medicine (Maywood, N.J.). 227: 845-51. PMID 12424324  0.32
2002 Khachik F, de Moura FF, Zhao DY, Aebischer CP, Bernstein PS. Transformations of selected carotenoids in plasma, liver, and ocular tissues of humans and in nonprimate animal models. Investigative Ophthalmology & Visual Science. 43: 3383-92. PMID 12407147  0.32
2002 Kucuk O, Sarkar FH, Sakr W, Khachik F, Djuric Z, Banerjee M, Pollak MN, Bertram JS, Wood DP. Lycopene in the treatment of prostate cancer Pure and Applied Chemistry. 74: 1443-1450.  0.32
2001 Kucuk O, Sarkar FH, Sakr W, Djuric Z, Pollak MN, Khachik F, Li YW, Banerjee M, Grignon D, Bertram JS, Crissman JD, Pontes EJ, Wood D.P. J. Phase II randomized clinical trial of lycopene supplementation before radical prostatectomy Cancer Epidemiology Biomarkers and Prevention. 10: 861-868. PMID 11489752  0.32
2001 Bernstein PS, Khachik F, Carvalho LS, Muir GJ, Zhao DY, Katz NB. Identification and quantitation of carotenoids and their metabolites in the tissues of the human eye. Experimental Eye Research. 72: 215-23. PMID 11180970 DOI: 10.1006/exer.2000.0954  0.32
2001 Jarrell N, Khachik F, Jarvis BB. New stereoselective method for carotenoid synthesis Chemtracts. 14: 529-538.  0.32
2000 Nishino H, Tokuda H, Murakoshi M, Satomi Y, Masuda M, Onozuka M, Yamaguchi S, Takayasu J, Tsuruta J, Okuda M, Khachik F, Narisawa T, Takasuka N, Yano M. Cancer prevention by natural carotenoids Biofactors. 13: 89-94. PMID 11237205  0.32
2000 Hata TR, Scholz TA, Ermakov IV, McClane RW, Khachik F, Gellermann W, Pershing LK. Non-invasive raman spectroscopic detection of carotenoids in human skin. The Journal of Investigative Dermatology. 115: 441-8. PMID 10951281 DOI: 10.1046/j.1523-1747.2000.00060.x  0.32
1999 Cohen LA, Zhao Z, Pittman B, Khachik F. Effect of dietary lycopene on N-methylnitrosourea-induced mammary tumorigenesis Nutrition and Cancer. 34: 153-159. PMID 10578482  0.32
1999 Khachik F, Steck A, Pfander H. Isolation and structural elucidation of (13Z,13'Z,3R,3'R,6'R)-lutein from marigold flowers, kale, and human plasma Journal of Agricultural and Food Chemistry. 47: 455-461. PMID 10563916 DOI: 10.1021/jf980823w  0.32
1998 Paetau I, Khachik F, Brown ED, Beecher GR, Kramer TR, Chittams J, Clevidence BA. Chronic ingestion of lycopene-rich tomato juice or lycopene supplements significantly increases plasma concentrations of lycopene and related tomato carotenoids in humans. The American Journal of Clinical Nutrition. 68: 1187-95. PMID 9846845  0.32
1998 Zhao Z, Khachik F, Richie JP, Cohen LA. Lycopene uptake and tissue disposition in male and female rats Proceedings of the Society For Experimental Biology and Medicine. 218: 109-114. PMID 9605207  0.32
1998 Kim JM, Araki S, Kim DJ, Park CB, Takasuka N, Baba-Toriyama H, Ota T, Nir Z, Khachik F, Shimidzu N, Tanaka Y, Osawa T, Uraji T, Murakoshi M, Nishino H, et al. Chemopreventive effects of carotenoids and curcumins on mouse colon carcinogenesis after 1,2-dimethylhydrazine initiation Carcinogenesis. 19: 81-85. PMID 9472697 DOI: 10.1093/carcin/19.1.81  0.32
1998 Khachik F, Cohen LA, Zhao Z. Metabolism of Dietary Carotenoids and Their Potential Role in Prevention of Cancer and Age-Related Macular Degeneration Acs Symposium Series. 701: 71-85.  0.32
1998 Khachik F, Pfander H, Traber B. Proposed Mechanisms for the Formation of Synthetic and Naturally Occurring Metabolites of Lycopene in Tomato Products and Human Serum Journal of Agricultural and Food Chemistry. 46: 4885-4890.  0.32
1998 Khachik F, Steck A, Niggli UA, Pfander H. Partial Synthesis and Structural Elucidation of the Oxidative Metabolites of Lycopene Identified in Tomato Paste, Tomato Juice, and Human Serum Journal of Agricultural and Food Chemistry. 46: 4874-4884.  0.32
1997 Khachik F, Bernstein PS, Garland DL. Identification of lutein and zeaxanthin oxidation products in human and monkey retinas. Investigative Ophthalmology & Visual Science. 38: 1802-11. PMID 9286269  0.32
1997 Khachik F, Spangler CJ, Smith JC, Canfield LM, Steck A, Pfander H. Identification, Quantification, and Relative Concentrations of Carotenoids and Their Metabolites in Human Milk and Serum Analytical Chemistry. 69: 1873-1881. PMID 9164160  0.32
1997 King TJ, Khachik F, Bortkiewicz H, Fukushima LH, Morioka S, Bertram JS. Metabolites of dietary carotenoids as potential cancer preventive agents Pure and Applied Chemistry. 69: 2135-2140.  0.32
1996 Narisawa T, Fukaura Y, Hasebe M, Ito M, Aizawa R, Murakoshi M, Uemura S, Khachik F, Nishino H. Inhibitory effects of natural carotenoids, α-carotene, β-carotene, lycopene and lutein, on colonic aberrant crypt foci formation in rats Cancer Letters. 107: 137-142. PMID 8913278 DOI: 10.1016/0304-3835(96)04354-6  0.32
1995 Khachik F, Englert G, Beecher GR, Cecil Smith J. Isolation, structural elucidation, and partial synthesis of lutein dehydration products in extracts from human plasma Journal of Chromatography B: Biomedical Sciences and Applications. 670: 219-233. PMID 8548012 DOI: 10.1016/0378-4347(95)00169-7  0.32
1995 Khachik F, Beecher GR, Smith JC. Lutein, lycopene, and their oxidative metabolites in chemoprevention of cancer Journal of Cellular Biochemistry. 58: 236-246. PMID 8538204  0.32
1995 Khachik F, Beecher GR, Li BW, Englert G. Synthesis of 13C-labelled (all-E,3R,3'R)-β-β-carotene-3,3'-diol (zeaxanthin) at C(12), C(13), C(12'), and C(13') via all-E-2,7-dimethylocta-2,4,6-triene-1,8-dial-13C4 Journal of Labelled Compounds and Radiopharmaceuticals. 36: 1157-1172. DOI: 10.1002/jlcr.2580361206  0.32
1995 Tonucci LH, Holden JM, Beecher GR, Khachik F, Davis CS, Mulokozi G. Carotenoid content of thermally processed tomato-based food products Journal of Agricultural and Food Chemistry. 43: 579-586.  0.32
1992 Micozzi MS, Brown ED, Edwards BK, Bieri JG, Taylor PR, Khachik F, Beecher GR, Smith JC. Plasma carotenoid response to chronic intake of selected foods and beta-carotene supplements in men. The American Journal of Clinical Nutrition. 55: 1120-5. PMID 1595584  0.32
1992 Khachik F, Englert G, Daitch CE, Beecher GR, Tonucci LH, Lusby WR. Isolation and structural elucidation of the geometrical isomers of lutein and zeaxanthin in extracts from human plasma Journal of Chromatography B: Biomedical Sciences and Applications. 582: 153-166. PMID 1491035 DOI: 10.1016/0378-4347(92)80314-G  0.32
1992 Beecher GR, Khachik F. Qualitative relationship of dietary and plasma carotenoids in human beings Annals of the New York Academy of Sciences. 669: 320-321. PMID 1444037  0.32
1992 Khachik F, Beecher GR, Goli MB, Lusby WR. Separation and quantitation of carotenoids in foods Methods in Enzymology. 213: 347-359. PMID 1435310 DOI: 10.1016/0076-6879(92)13136-L  0.32
1992 Khachik F, Beecher GR, Goli MB, Lusby WR, Daitch CE. Separation and quantification of carotenoids in human plasma Methods in Enzymology. 213: 205-219. PMID 1435303 DOI: 10.1016/0076-6879(92)13122-E  0.32
1992 Khachik F, Beecher GR, Goli MB, Lusby WR, Smith JC. Separation and identification of carotenoids and their oxidation products in the extracts of human plasma Analytical Chemistry. 64: 2111-2122. PMID 1416048  0.32
1992 Lusby WR, Khachik F, Beecher GR, Lau J. Gas-phase reaction mass spectrometric analysis of carotenoids Methods in Enzymology. 213: 111-128. DOI: 10.1016/0076-6879(92)13116-F  0.32
1992 Khachik F, Goli MB, Beecher GR, Holden J, Lusby WR, Tenorio MD, Barrera MR. Effect of food preparation on qualitative and quantitative distribution of major carotenoid constituents of tomatoes and several green vegetables Journal of Agricultural and Food Chemistry. 40: 390-398.  0.32
1991 Khachik F, Beecher GR, Goli MB, Lusby WR. Separation, identification, and quantification of carotenoids in fruits, vegetables and human plasma by high performance liquid chromatography Pure and Applied Chemistry. 63: 71-80. DOI: 10.1351/pac199163010071  0.32
1990 Micozzi MS, Beecher GR, Taylor PR, Khachik F. Carotenoid analyses of selected raw and cooked foods associated with a lower risk for cancer Journal of the National Cancer Institute. 82: 282-285. PMID 2299676 DOI: 10.1093/jnci/82.4.282  0.32
1990 Houk KN, Mueller PH, Wu YD, Mazzocchi PH, Shook D, Khachik F. Cycloadditions of hexachlorocyclopentadiene to 7-substituted norbornadienes: remote substituent effects on reacfivity and stereoselectivity Tetrahedron Letters. 31: 7285-7288. DOI: 10.1016/S0040-4039(00)88545-7  0.32
1989 Khachik F, Beecher GR, Lusby WR. Separation, identification, and quantification of the major carotenoids in extracts of apricots, peaches, cantaloupe, and pink grapefruit by liquid chromatography Journal of Agricultural and Food Chemistry. 37: 1465-1473.  0.32
1988 Khachik F. Liquid chromatographic artifacts and peak distortion: sample-solvent interactions in the separation of carotenoids Analytical Chemistry. 60: 807-811. PMID 3369703  0.32
1988 Khachik F, Beecher GR. Separation of carotenol fatty acid esters by high-performance liquid chromatography Journal of Chromatography A. 449: 119-133. PMID 3235576 DOI: 10.1016/S0021-9673(00)94373-5  0.32
1988 Khachik F, Beecher GR. Separation and identification of carotenoids and carotenol fatty acid esters in some squash products by liquid chromatography. 1. Quantification of carotenoids and related esters by HPLC Journal of Agricultural and Food Chemistry. 36: 929-937.  0.32
1988 Khachik F, Beecher GR, Lusby WR. Separation and identification of carotenoids and carotenol fatty acid esters in some squash products by liquid chromatography. 2. Isolation and characterization of carotenoids and related esters Journal of Agricultural and Food Chemistry. 36: 938-946.  0.32
1987 Khachik F, Beecher GR. Rebuttal on quantification of major carotenoids in raw fruits and vegetables by HPLC [3] Journal of Agricultural and Food Chemistry. 35: 850.  0.32
1987 Khachik F, Beecher GR. Application of a C-45-β-carotene as an internal standard for the quantification of carotenoids in yellow/orange vegetables by liquid chromatography Journal of Agricultural and Food Chemistry. 35: 732-738.  0.32
1986 Khachik F, Beecher GR, Whittaker NF. Separation, identification, and quantification of the major carotenoid and chlorophyll constituents in extracts of several green vegetables by liquid chromatography Journal of Agricultural and Food Chemistry. 34: 603-616.  0.32
1985 Khachik F, Beecher GR. Decapreno-β-carotene as an internal standard for the quantification of the hydrocarbon carotenoids by high-performance liquid chromatography Journal of Chromatography A. 346: 237-246. PMID 3841351 DOI: 10.1016/S0021-9673(00)90509-0  0.32
1984 Beecher GR, Khachik F. Evaluation of vitamin A and carotenoid data in food composition tables Journal of the National Cancer Institute. 73: 1397-1404. PMID 6392673 DOI: 10.1093/jnci/73.6.1397  0.32
1983 Mazzocchi PH, Khachik F. Directive Effects of Substituents on the Electron Transfer Photoreduction of N-Methylphthalimide by 2,3-Dimethyl-2-butene Tetrahedron Letters. 24: 1879-1882. DOI: 10.1016/S0040-4039(00)81795-5  0.32
1983 Mazzocchi PH, Wilson P, Khachik F, Klingler L, Minamikawa S. Photochemical additions of alkenes to phthalimides. Mechanistic investigations on the stereochemistry of alkene additions and the effect of aryl substituents on the regiochemistry of alkene additions Journal of Organic Chemistry. 48: 2981-2989.  0.32
1981 Mazzocchi PH, Khachik F. The regiochemistry of trapped radical anion-radical cation pairs from aryl substituted phthalimides Tetrahedron Letters. 22: 4189-4192. DOI: 10.1016/S0040-4039(01)82100-6  0.32
1981 Mazzocchi PH, Khachik F, Wilson P, Highet R. Photochemical additions of alkenes to n-methylphthalimides. Effect of aryl substituents on the direction of addition Journal of the American Chemical Society. 103: 6498-6499.  0.32
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