Patricia Ernst - Publications

Affiliations: 
2004-2014 Biochemistry Dartmouth College, Hanover, NH, United States 
 2014- University of Colorado School of Medicine, Aurora, CO, United States 
Area:
Genetics, Molecular Biology, Cell Biology
Website:
http://www.ucdenver.edu/academics/colleges/medicalschool/departments/medicine/Hematology/bloodcancerandbmtprogram/people/faculty/Pages/Patricia-Ernst.aspx

42 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Chen Y, Ernst P. Hematopoietic transformation in the absence of MLL1/KMT2A: distinctions in target gene reactivation. Cell Cycle (Georgetown, Tex.). 1-7. PMID 31161857 DOI: 10.1080/15384101.2019.1618642  0.32
2018 Chen Y, Jones KL, Anastassiadis K, Kranz A, Stewart AF, Grembecka J, Meyerson M, Ernst P. Distinct Pathways Affected by Menin versus MLL1/MLL2 in MLL-rearranged Acute Myeloid Leukemia. Experimental Hematology. PMID 30315824 DOI: 10.1016/j.exphem.2018.10.001  0.32
2018 Gan T, Li BE, Mishra BP, Jones KL, Ernst P. MLL1 Promotes IL-7 Responsiveness and Survival during B Cell Differentiation. Journal of Immunology (Baltimore, Md. : 1950). PMID 29351999 DOI: 10.4049/jimmunol.1701572  0.32
2017 Chen Y, Anastassiadis K, Kranz A, Stewart AF, Arndt K, Waskow C, Yokoyama A, Jones K, Neff T, Lee Y, Ernst P. MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia. Cancer Cell. 31: 755-770.e6. PMID 28609655 DOI: 10.1016/j.ccell.2017.05.002  0.32
2016 Xu H, Valerio DG, Eisold ME, Sinha A, Koche RP, Hu W, Chen CW, Chu SH, Brien GL, Park CY, Hsieh JJ, Ernst P, Armstrong SA. NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis. Cancer Cell. PMID 27889185 DOI: 10.1016/j.ccell.2016.10.019  1
2016 Watanabe T, Ernst P. Context, Context, Context: New Gene Programs Linked to Bad Behavior in MLL-AF9-Initiated Leukemia. Cancer Cell. 30: 3-5. PMID 27411579 DOI: 10.1016/j.ccell.2016.06.011  1
2016 Riedel SS, Haladyna JN, Bezzant M, Stevens B, Pollyea DA, Sinha AU, Armstrong SA, Wei Q, Pollock RM, Daigle SR, Jordan CT, Ernst P, Neff T, Bernt KM. MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia. The Journal of Clinical Investigation. PMID 26927674 DOI: 10.1172/JCI80825  1
2015 Harte PJ, Ernst P. Harnessing gene repression to inhibit leukemia. Nature Medicine. 21: 308-10. PMID 25849269 DOI: 10.1038/nm.3834  1
2014 Li BE, Ernst P. Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia. Experimental Hematology. 42: 995-1012. PMID 25264566 DOI: 10.1016/j.exphem.2014.09.006  1
2014 Mishra BP, Zaffuto KM, Artinger EL, Org T, Mikkola HK, Cheng C, Djabali M, Ernst P. The histone methyltransferase activity of MLL1 is dispensable for hematopoiesis and leukemogenesis. Cell Reports. 7: 1239-47. PMID 24813891 DOI: 10.1016/j.celrep.2014.04.015  1
2013 Artinger EL, Ernst P. Cell context in the control of self-renewal and proliferation regulated by MLL1. Cell Cycle (Georgetown, Tex.). 12: 2969-72. PMID 23974107 DOI: 10.4161/cc.26032  1
2013 Li BE, Gan T, Meyerson M, Rabbitts TH, Ernst P. Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells. Blood. 122: 2039-46. PMID 23908472 DOI: 10.1182/blood-2013-03-486647  1
2013 Huang LH, Gui J, Artinger E, Craig R, Berwin BL, Ernst PA, Chang CC, Chang TY. Acat1 gene ablation in mice increases hematopoietic progenitor cell proliferation in bone marrow and causes leukocytosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 2081-7. PMID 23846496 DOI: 10.1161/ATVBAHA.112.301080  1
2013 Artinger EL, Mishra BP, Zaffuto KM, Li BE, Chung EK, Moore AW, Chen Y, Cheng C, Ernst P. An MLL-dependent network sustains hematopoiesis. Proceedings of the National Academy of Sciences of the United States of America. 110: 12000-5. PMID 23744037 DOI: 10.1073/pnas.1301278110  1
2012 Stan RV, Tse D, Deharvengt SJ, Smits NC, Xu Y, Luciano MR, McGarry CL, Buitendijk M, Nemani KV, Elgueta R, Kobayashi T, Shipman SL, Moodie KL, Daghlian CP, Ernst PA, et al. The diaphragms of fenestrated endothelia: gatekeepers of vascular permeability and blood composition. Developmental Cell. 23: 1203-18. PMID 23237953 DOI: 10.1016/j.devcel.2012.11.003  1
2012 Ernst P, Vakoc CR. WRAD: enabler of the SET1-family of H3K4 methyltransferases. Briefings in Functional Genomics. 11: 217-26. PMID 22652693 DOI: 10.1093/bfgp/els017  1
2011 Cai X, Gaudet JJ, Mangan JK, Chen MJ, De Obaldia ME, Oo Z, Ernst P, Speck NA. Runx1 loss minimally impacts long-term hematopoietic stem cells. Plos One. 6: e28430. PMID 22145044 DOI: 10.1371/journal.pone.0028430  1
2011 Malgrange B, Borgs L, Grobarczyk B, Purnelle A, Ernst P, Moonen G, Nguyen L. Using human pluripotent stem cells to untangle neurodegenerative disease mechanisms. Cellular and Molecular Life Sciences : Cmls. 68: 635-49. PMID 20976521 DOI: 10.1007/s00018-010-0557-6  1
2010 Gan T, Jude CD, Zaffuto K, Ernst P. Developmentally induced Mll1 loss reveals defects in postnatal haematopoiesis Leukemia. 24: 1732-1741. PMID 20724987 DOI: 10.1038/leu.2010.171  1
2010 Thiel AT, Blessington P, Zou T, Feather D, Wu X, Yan J, Zhang H, Liu Z, Ernst P, Koretzky GA, Hua X. MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele. Cancer Cell. 17: 148-59. PMID 20159607 DOI: 10.1016/j.ccr.2009.12.034  1
2009 Passegué E, Ernst P. IFN-alpha wakes up sleeping hematopoietic stem cells. Nature Medicine. 15: 612-3. PMID 19498372 DOI: 10.1038/nm0609-612  1
2009 Lim DA, Huang YC, Swigut T, Mirick AL, Garcia-Verdugo JM, Wysocka J, Ernst P, Alvarez-Buylla A. Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells. Nature. 458: 529-33. PMID 19212323 DOI: 10.1038/nature07726  1
2009 Ernst P. Hematopoietic stem cells Molecular Basis of Hematopoiesis. 1-22. DOI: 10.1007/978-0-387-85816-6_1  1
2008 Jude CD, Gaudet JJ, Speck NA, Ernst P. Leukemia and hematopoietic stem cells: balancing proliferation and quiescence. Cell Cycle (Georgetown, Tex.). 7: 586-91. PMID 18239455  1
2007 Jude CD, Climer L, Xu D, Artinger E, Fisher JK, Ernst P. Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors. Cell Stem Cell. 1: 324-37. PMID 18371366 DOI: 10.1016/j.stem.2007.05.019  1
2006 Bansal D, Scholl C, Fröhling S, McDowell E, Lee BH, Döhner K, Ernst P, Davidson AJ, Daley GQ, Zon LI, Gilliland DG, Huntly BJ. Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model. Proceedings of the National Academy of Sciences of the United States of America. 103: 16924-9. PMID 17068127 DOI: 10.1073/pnas.0604579103  1
2005 Wang Y, Yates F, Naveiras O, Ernst P, Daley GQ. Embryonic stem cell-derived hematopoietic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 102: 19081-6. PMID 16357205 DOI: 10.1073/pnas.0506127102  1
2005 Wang J, Iwasaki H, Krivtsov A, Febbo PG, Thorner AR, Ernst P, Anastasiadou E, Kutok JL, Kogan SC, Zinkel SS, Fisher JK, Hess JL, Golub TR, Armstrong SA, Akashi K, et al. Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease. The Embo Journal. 24: 368-81. PMID 15635450 DOI: 10.1038/sj.emboj.7600521  1
2004 Ernst P, Mabon M, Davidson AJ, Zon LI, Korsmeyer SJ. An Mll-dependent Hox program drives hematopoietic progenitor expansion. Current Biology : Cb. 14: 2063-9. PMID 15556871 DOI: 10.1016/j.cub.2004.11.012  1
2004 Ernst P, Fisher JK, Avery W, Wade S, Foy D, Korsmeyer SJ. Definitive hematopoiesis requires the mixed-lineage leukemia gene. Developmental Cell. 6: 437-43. PMID 15030765  1
2003 Davidson AJ, Ernst P, Wang Y, Dekens MP, Kingsley PD, Palis J, Korsmeyer SJ, Daley GQ, Zon LI. cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes. Nature. 425: 300-6. PMID 13679919 DOI: 10.1038/nature01973  1
2003 Hsieh JJ, Ernst P, Erdjument-Bromage H, Tempst P, Korsmeyer SJ. Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization. Molecular and Cellular Biology. 23: 186-94. PMID 12482972  1
2002 Ernst P, Wang J, Korsmeyer SJ. The role of MLL in hematopoiesis and leukemia. Current Opinion in Hematology. 9: 282-7. PMID 12042701  1
2001 Trinh LA, Ferrini R, Cobb BS, Weinmann AS, Hahm K, Ernst P, Garraway IP, Merkenschlager M, Smale ST. Down-regulation of TDT transcription in CD4(+)CD8(+) thymocytes by Ikaros proteins in direct competition with an Ets activator. Genes & Development. 15: 1817-32. PMID 11459831 DOI: 10.1101/gad.905601  1
2001 Ernst P, Wang J, Huang M, Goodman RH, Korsmeyer SJ. MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein. Molecular and Cellular Biology. 21: 2249-58. PMID 11259575 DOI: 10.1128/MCB.21.7.2249-2258.2001  1
1999 Ernst P, Hahm K, Cobb BS, Brown KE, Trinh LA, McCarty AS, Merkenschlager M, Klug CA, Fisher AG, Smale ST. Mechanisms of transcriptional regulation in lymphocyte progenitors: insight from an analysis of the terminal transferase promoter. Cold Spring Harbor Symposia On Quantitative Biology. 64: 87-97. PMID 11232341  1
1999 Hanson RD, Hess JL, Yu BD, Ernst P, van Lohuizen M, Berns A, van der Lugt NM, Shashikant CS, Ruddle FH, Seto M, Korsmeyer SJ. Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development. Proceedings of the National Academy of Sciences of the United States of America. 96: 14372-7. PMID 10588712 DOI: 10.1073/pnas.96.25.14372  1
1996 Ernst P, Hahm K, Trinh L, Davis JN, Roussel MF, Turck CW, Smale ST. A potential role for Elf-1 in terminal transferase gene regulation. Molecular and Cellular Biology. 16: 6121-31. PMID 8887642  1
1995 Ernst P, Smale ST. Combinatorial regulation of transcription II: The immunoglobulin mu heavy chain gene. Immunity. 2: 427-38. PMID 7749979 DOI: 10.1016/1074-7613(95)90024-1  1
1995 Ernst P, Smale ST. Combinatorial regulation of transcription. I: General aspects of transcriptional control. Immunity. 2: 311-9. PMID 7719936 DOI: 10.1016/1074-7613(95)90139-6  1
1994 Hahm K, Ernst P, Lo K, Kim GS, Turck C, Smale ST. The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene. Molecular and Cellular Biology. 14: 7111-23. PMID 7935426  1
1993 Ernst P, Hahm K, Smale ST. Both LyF-1 and an Ets protein interact with a critical promoter element in the murine terminal transferase gene. Molecular and Cellular Biology. 13: 2982-92. PMID 8474456  1
Show low-probability matches.