Jane V. Aldrich - Publications

Affiliations: 
2001-2015 Medicinal Chemistry University of Kansas, Lawrence, KS, United States 
 2015- University of Florida, Gainesville, Gainesville, FL, United States 
Area:
Pharmaceutical Chemistry
Website:
https://pharmacy.ufl.edu/faculty/jane-aldrich/

73 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Fang WJ, Murray TF, Aldrich JV. Design, synthesis, and opioid activity of arodyn analogs cyclized by ring-closing metathesis involving Tyr(allyl). Bioorganic & Medicinal Chemistry. PMID 29273415 DOI: 10.1016/j.bmc.2017.11.029  0.68
2017 Joshi AA, Murray TF, Aldrich JV. Alanine scan of the opioid peptide dynorphin B amide. Biopolymers. PMID 28464209 DOI: 10.1002/bip.23026  0.44
2016 Khaliq T, Williams TD, Senadheera SN, Aldrich JV. Development of a robust, sensitive and selective liquid chromatography-tandem mass spectrometry assay for the quantification of the novel macrocyclic peptide kappa opioid receptor antagonist [D-Trp]CJ-15,208 in plasma and application to an initial pharmacokinetic study. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 1028: 11-15. PMID 27318293 DOI: 10.1016/j.jchromb.2016.05.043  0.68
2016 Sirohi S, Aldrich JV, Walker BM. Species differences in the effects of the κ-opioid receptor antagonist zyklophin. Alcohol (Fayetteville, N.Y.). 51: 43-9. PMID 26992699 DOI: 10.1016/j.alcohol.2015.11.012  0.68
2016 Huang P, Yakovleva T, Aldrich JV, Tunis J, Parry C, Liu-Chen LY. Two short-acting kappa opioid receptor antagonists (zyklophin and LY2444296) exhibited different behavioral effects from the long-acting antagonist norbinaltorphimine in mouse anxiety tests. Neuroscience Letters. PMID 26780565 DOI: 10.1016/j.neulet.2016.01.017  0.68
2015 Joshi A, Murray TF, Aldrich JV. Structure-Activity Relationships of the Peptide Kappa Opioid Receptor Antagonist Zyklophin. Journal of Medicinal Chemistry. PMID 26491810 DOI: 10.1021/jm501827k  0.68
2014 Aldrich JV, Senadheera SN, Ross NC, Reilley KA, Ganno ML, Eans SE, Murray TF, McLaughlin JP. Alanine analogues of [D-Trp]CJ-15,208: novel opioid activity profiles and prevention of drug- and stress-induced reinstatement of cocaine-seeking behaviour. British Journal of Pharmacology. 171: 3212-22. PMID 24588614 DOI: 10.1111/bph.12664  0.68
2014 Dimattio KM, Yakovleva TV, Aldrich JV, Cowan A, Liu-Chen LY. Zyklophin, a short-acting kappa opioid antagonist, induces scratching in mice. Neuroscience Letters. 563: 155-9. PMID 24503508 DOI: 10.1016/j.neulet.2014.01.022  0.68
2013 Mukhopadhyay A, Tabanor K, Chaguturu R, Aldrich JV. Targeting inhibitor 2 of protein phosphatase 2A as a therapeutic strategy for prostate cancer treatment. Cancer Biology & Therapy. 14: 962-72. PMID 24025258 DOI: 10.4161/cbt.25943  0.68
2013 Eans SO, Ganno ML, Reilley KJ, Patkar KA, Senadheera SN, Aldrich JV, McLaughlin JP. The macrocyclic tetrapeptide [D-Trp]CJ-15,208 produces short-acting κ opioid receptor antagonism in the CNS after oral administration. British Journal of Pharmacology. 169: 426-36. PMID 23425081 DOI: 10.1111/bph.12132  0.68
2013 Zhou Y, Leri F, Grella SL, Aldrich JV, Kreek MJ. Involvement of dynorphin and kappa opioid receptor in yohimbine-induced reinstatement of heroin seeking in rats. Synapse (New York, N.Y.). 67: 358-61. PMID 23345075 DOI: 10.1002/syn.21638  0.68
2013 Aldrich JV, Senadheera SN, Ross NC, Ganno ML, Eans SO, McLaughlin JP. The macrocyclic peptide natural product CJ-15,208 is orally active and prevents reinstatement of extinguished cocaine-seeking behavior. Journal of Natural Products. 76: 433-8. PMID 23327691 DOI: 10.1021/np300697k  0.68
2012 Aldrich JV, McLaughlin JP. Opioid Peptides: Potential for Drug Development. Drug Discovery Today. Technologies. 9: e23-e31. PMID 23316256 DOI: 10.1016/j.ddtec.2011.07.007  0.68
2012 Sloan CD, Audus KL, Aldrich JV, Lunte SM. The permeation of dynorphin A 1-6 across the blood brain barrier and its effect on bovine brain microvessel endothelial cell monolayer permeability. Peptides. 38: 414-7. PMID 23046728 DOI: 10.1016/j.peptides.2012.09.031  0.68
2012 Kuhnline Sloan CD, Nandi P, Linz TH, Aldrich JV, Audus KL, Lunte SM. Analytical and biological methods for probing the blood-brain barrier. Annual Review of Analytical Chemistry (Palo Alto, Calif.). 5: 505-31. PMID 22708905 DOI: 10.1146/annurev-anchem-062011-143002  0.68
2012 Ross NC, Reilley KJ, Murray TF, Aldrich JV, McLaughlin JP. Novel opioid cyclic tetrapeptides: Trp isomers of CJ-15,208 exhibit distinct opioid receptor agonism and short-acting κ opioid receptor antagonism. British Journal of Pharmacology. 165: 1097-108. PMID 21671905 DOI: 10.1111/j.1476-5381.2011.01544.x  0.68
2011 Fang WJ, Yakovleva T, Aldrich JV. A convenient approach to synthesizing peptide C-terminal N-alkyl amides. Biopolymers. 96: 715-22. PMID 22252422 DOI: 10.1002/bip.21600  0.68
2011 Aldrich JV, Kulkarni SS, Senadheera SN, Ross NC, Reilley KJ, Eans SO, Ganno ML, Murray TF, McLaughlin JP. Unexpected opioid activity profiles of analogues of the novel peptide kappa opioid receptor ligand CJ-15,208. Chemmedchem. 6: 1739-45. PMID 21761566 DOI: 10.1002/cmdc.201100113  0.68
2011 Kelamangalath L, Dravid SM, George J, Aldrich JV, Murray TF. κ-Opioid receptor inhibition of calcium oscillations in spinal cord neurons. Molecular Pharmacology. 79: 1061-71. PMID 21422300 DOI: 10.1124/mol.111.071456  0.68
2011 Fang WJ, Bennett MA, Aldrich JV. Deletion of Ac-NMePhe(1) from [NMePhe(1) ]arodyn under acidic conditions, part 1: effects of cleavage conditions and N-terminal functionality. Biopolymers. 96: 97-102. PMID 20560149 DOI: 10.1002/bip.21496  0.68
2011 Fang WJ, Bennett MA, Murray TF, Aldrich JV. Deletion of Ac-NMePhe(1) from [NMePhe(1) ]arodyn under acidic conditions, part 2: effects of substitutions on pharmacological activity. Biopolymers. 96: 103-10. PMID 20560148 DOI: 10.1002/bip.21495  0.68
2010 Ross NC, Kulkarni SS, McLaughlin JP, Aldrich JV. Synthesis of CJ-15,208, a novel κ-opioid receptor antagonist. Tetrahedron Letters. 51: 5020-5023. PMID 22865937 DOI: 10.1016/j.tetlet.2010.07.086  0.68
2009 Aldrich JV, Patkar KA, McLaughlin JP. Zyklophin, a systemically active selective kappa opioid receptor peptide antagonist with short duration of action. Proceedings of the National Academy of Sciences of the United States of America. 106: 18396-401. PMID 19841255 DOI: 10.1073/pnas.0910180106  0.68
2009 Patkar KA, Murray TF, Aldrich JV. The effects of C-terminal modifications on the opioid activity of [N-benzylTyr(1)]dynorphin A-(1-11) analogues. Journal of Medicinal Chemistry. 52: 6814-21. PMID 19807094 DOI: 10.1021/jm900715m  0.68
2009 Fang WJ, Cui Y, Murray TF, Aldrich JV. Design, synthesis, and pharmacological activities of dynorphin A analogues cyclized by ring-closing metathesis. Journal of Medicinal Chemistry. 52: 5619-25. PMID 19715279 DOI: 10.1021/jm900577k  0.68
2009 Sinha B, Cao Z, Murray TF, Aldrich JV. Discovery of dermorphin-based affinity labels with subnanomolar affinity for mu opioid receptors. Journal of Medicinal Chemistry. 52: 7372-5. PMID 19621878 DOI: 10.1021/jm9007592  0.68
2009 Aldrich JV, McLaughlin JP. Peptide kappa opioid receptor ligands: potential for drug development. The Aaps Journal. 11: 312-22. PMID 19430912 DOI: 10.1208/s12248-009-9105-4  0.68
2009 Fang WJ, Kulkarni SS, Murray TF, Aldrich JV. Design and synthesis of cyclic arodyn analogues by ring-closing metathesis (RCM) for kappa opioid receptor (KOP) antagonists. Advances in Experimental Medicine and Biology. 611: 279-80. PMID 19400192 DOI: 10.1007/978-0-387-73657-0_125  0.68
2009 Kulkarni SS, Ross NC, McLaughlin JP, Aldrich JV. Synthesis of cyclic tetrapeptide CJ 15,208: a novel kappa opioid receptor antagonist. Advances in Experimental Medicine and Biology. 611: 269-70. PMID 19400188 DOI: 10.1007/978-0-387-73657-0_121  0.68
2009 Dattachowdhury B, Murray TF, Aldrich JV. The synthesis of DAMGO-based potential affinity labels with high mu opioid receptor affinity and the formation of cyclic O-alkyl thiocarbamates. Advances in Experimental Medicine and Biology. 611: 265-6. PMID 19400186 DOI: 10.1007/978-0-387-73657-0_119  0.68
2009 Aldrich JV, Kumar V, Murray TF, Guang W, Wang JB. Dual labeled peptides as tools to study receptors: nanomolar affinity derivatives of TIPP (Tyr-Tic-Phe-Phe) containing an affinity label and biotin as probes of delta opioid receptors. Bioconjugate Chemistry. 20: 201-4. PMID 19175314 DOI: 10.1021/bc800420t  0.68
2009 Patkar KA, Highsmith WE, Aldrich JV. Solid phase and solution synthesis of NvocLys(CO(CH2)5NH-NBD)OCH2CN, a trifunctional fluorescent lysine derivative. Amino Acids. 36: 203-7. PMID 18365133 DOI: 10.1007/s00726-008-0048-3  0.68
2008 Aldrich JV, Kumar V, Dattachowdhury B, Peck AM, Wang X, Murray TF. Solid Phase Synthesis and Application of Labeled Peptide Derivatives: Probes of Receptor-Opioid Peptide Interactions. International Journal of Peptide Research and Therapeutics. 14: 315-321. PMID 19956785 DOI: 10.1007/s10989-008-9144-1  0.68
2008 Charoenchai L, Wang H, Wang JB, Aldrich JV. High affinity conformationally constrained nociceptin/orphanin FQ(1-13) amide analogues. Journal of Medicinal Chemistry. 51: 4385-7. PMID 18624395 DOI: 10.1021/jm800394v  0.68
2007 Carey AN, Borozny K, Aldrich JV, McLaughlin JP. Reinstatement of cocaine place-conditioning prevented by the peptide kappa-opioid receptor antagonist arodyn. European Journal of Pharmacology. 569: 84-9. PMID 17568579 DOI: 10.1016/j.ejphar.2007.05.007  0.68
2005 Patkar KA, Yan X, Murray TF, Aldrich JV. [Nalpha-benzylTyr1,cyclo(D-Asp5,Dap8)]- dynorphin A-(1-11)NH2 cyclized in the "address" domain is a novel kappa-opioid receptor antagonist. Journal of Medicinal Chemistry. 48: 4500-3. PMID 15999987 DOI: 10.1021/jm050105i  0.68
2005 Marinova Z, Vukojevic V, Surcheva S, Yakovleva T, Cebers G, Pasikova N, Usynin I, Hugonin L, Fang W, Hallberg M, Hirschberg D, Bergman T, Langel U, Hauser KF, Pramanik A, ... Aldrich JV, et al. Translocation of dynorphin neuropeptides across the plasma membrane. A putative mechanism of signal transmission. The Journal of Biological Chemistry. 280: 26360-70. PMID 15894804 DOI: 10.1074/jbc.M412494200  0.68
2005 Bennett MA, Murray TF, Aldrich JV. Structure-activity relationships of arodyn, a novel acetylated kappa opioid receptor antagonist. The Journal of Peptide Research : Official Journal of the American Peptide Society. 65: 322-32. PMID 15787962 DOI: 10.1111/j.1399-3011.2005.00216.x  0.68
2005 Hauser KF, Aldrich JV, Anderson KJ, Bakalkin G, Christie MJ, Hall ED, Knapp PE, Scheff SW, Singh IN, Vissel B, Woods AS, Yakovleva T, Shippenberg TS. Pathobiology of dynorphins in trauma and disease. Frontiers in Bioscience : a Journal and Virtual Library. 10: 216-35. PMID 15574363  0.68
2004 Aldrich JV, Choi H, Murray TF. An affinity label for δ-opioid receptors derived from [D-Ala 2]deltorphin I Journal of Peptide Research. 63: 108-115. PMID 15009532 DOI: 10.1111/j.1399-3011.2004.00122.x  0.68
2004 Vig BS, Murray TF, Aldrich JV. Synthesis and opioid activity of side-chain-to-side-chain cyclic dynorphin A-(1-11) amide analogues cyclized between positions 2 and 5. 1. Substitutions in position 3. Journal of Medicinal Chemistry. 47: 446-55. PMID 14711314 DOI: 10.1021/jm030298e  0.68
2004 Vig BS, Aldrich JV. An inexpensive, manually operated, solid-phase, parallel synthesizer Aldrichimica Acta. 37: 2.  0.68
2003 Vig BS, Murray TF, Aldrich JV. Synthesis of novel basic head-to-side-chain cyclic dynorphin A analogs: strategies and side reactions. Biopolymers. 71: 620-37. PMID 14991673 DOI: 10.1002/bip.10591  0.68
2003 Choi H, Murray TF, Aldrich JV. Synthesis and evaluation of derivatives of leucine enkephalin as potential affinity labels for delta opioid receptors. Biopolymers. 71: 552-7. PMID 14635095 DOI: 10.1002/bip.10533  0.68
2003 Vig BS, Zheng MQ, Murray TF, Aldrich JV. Effects of the substitution of Phe4 in the opioid peptide [D-Ala8]dynorphin A-(1-11)NH2. Journal of Medicinal Chemistry. 46: 4002-8. PMID 12954053 DOI: 10.1021/jm030075o  0.68
2003 Vig BS, Murray TF, Aldrich JV. A novel N-terminal cyclic dynorphin A analogue cyclo(N,5)[Trp(3),Trp(4),Glu(5)] dynorphin A-(1-11)NH(2) that lacks the basic N-terminus. Journal of Medicinal Chemistry. 46: 1279-82. PMID 12672226 DOI: 10.1021/jm0256023  0.68
2003 Kumar V, Aldrich JV. A solid-phase synthetic strategy for labeled peptides: synthesis of a biotinylated derivative of the delta opioid receptor antagonist TIPP (Tyr-Tic-Phe-Phe-OH). Organic Letters. 5: 613-6. PMID 12605472 DOI: 10.1021/ol027044s  0.68
2003 Choi H, Murray TF, Aldrich JV. Synthesis and evaluation of potential affinity labels derived from endomorphin-2 Journal of Peptide Research. 61: 58-62. PMID 12492899 DOI: 10.1034/j.1399-3011.2003.00029.x  0.68
2003 Choi H, Murray TF, Aldrich JV. Dermorphin-based potential affinity labels for μ-opioid receptors Journal of Peptide Research. 61: 40-45. PMID 12472847 DOI: 10.1034/j.1399-3011.2003.20030.x  0.68
2002 Bennett MA, Murray TF, Aldrich JV. Identification of arodyn, a novel acetylated dynorphin A-(1-11) analogue, as a kappa opioid receptor antagonist. Journal of Medicinal Chemistry. 45: 5617-9. PMID 12477343 DOI: 10.1021/jm025575g  0.68
2002 Kumar V, Murray TF, Aldrich JV. Solid phase synthesis and evaluation of Tyr-Tic-Phe-Phe(p-NHCOCH(2)Br) ([Phe(p-bromoacetamide)(4)]TIPP), a potent affinity label for delta opioid receptors. Journal of Medicinal Chemistry. 45: 3820-3. PMID 12190304 DOI: 10.1021/jm020290p  0.68
2001 Aldrich JV, Zheng Q, Murray TF. Dynorphin A analogs containing a conformationally constrained phenylalanine derivative in position 4: Reversal of preferred stereochemistry for opioid receptor affinity and discrimination of κ vs. δ receptors Chirality. 13: 125-129. PMID 11270320 DOI: 10.1002/1520-636X(2001)13:3<125::AID-CHIR1008>3.0.CO;2-S  0.68
2000 Kumar V, Murray TF, Aldrich JV. Extended TIP(P) analogues as precursors for labeled δ-opioid receptor ligands Journal of Medicinal Chemistry. 43: 5050-5054. PMID 11150177 DOI: 10.1021/jm000362h  0.68
2000 Maeda DY, Berman F, Murray TF, Aldrich JV. Synthesis and evaluation of isothiocyanate-containing derivatives of the δ-opioid receptor antagonist Tyr-Tic-Phe-Phe (TIPP) as potential affinity labels for δ-opioid receptors Journal of Medicinal Chemistry. 43: 5044-5049. PMID 11150176 DOI: 10.1021/jm000345s  0.68
2000 Maeda DY, Ishmael JE, Murray TF, Aldrich JV. Synthesis and evaluation of n,n-dialkyl enkephalin-based affinity labels for δ opioid receptors Journal of Medicinal Chemistry. 43: 3941-3948. PMID 11052799 DOI: 10.1021/jm000123u  0.68
2000 Leelasvatanakij L, Aldrich JV. A solid-phase synthetic strategy for the preparation of peptide-based affinity labels: Synthesis of dynorphin A analogs Journal of Peptide Research. 56: 80-87. PMID 10961542 DOI: 10.1034/j.1399-3011.2000.00736.x  0.68
1999 Wan Q, Murray TF, Aldrich JV. A novel acetylated analogue of dynorphin A-(1-11) amide as a κ-opioid receptor antagonist [1] Journal of Medicinal Chemistry. 42: 3011-3013. PMID 10447942 DOI: 10.1021/jm9901071  0.68
1999 Vigil-Cruz SC, Aldrich JV. Unexpected aspartimide formation during coupling reactions using Asp(OAI) in solid-phase peptide synthesis Letters in Peptide Science. 6: 71-75. DOI: 10.1023/A:1008871528559  0.68
1997 Soderstrom K, Choi H, Berman FW, Aldrich JV, Murray TF. N-Alkylated derivatives of [D-Pro10]dynorphin A-(1-11) are high affinity partial agonists at the cloned rat κ-opioid receptor European Journal of Pharmacology. 338: 191-197. PMID 9456002 DOI: 10.1016/S0014-2999(97)81948-6  0.68
1997 Choi H, Murray TF, DeLander GE, Schmidt WK, Aldrich JV. Synthesis and opioid activity of [D-Pro10]dynorphin A-(1-11) analogues with N-terminal alkyl substitution. Journal of Medicinal Chemistry. 40: 2733-9. PMID 9276018 DOI: 10.1021/jm960747t  0.68
1997 Arttamangkul S, Ishmael JE, Murray TF, Grandy DK, DeLander GE, Kieffer BL, Aldrich JV. Synthesis and opioid activity of conformationally constrained dynorphin A analogues. 2. Conformational constraint in the "address" sequence. Journal of Medicinal Chemistry. 40: 1211-8. PMID 9111295 DOI: 10.1021/jm960753p  0.68
1996 Jensen ON, Kulkarni S, Aldrich JV, Barofsky DF. Characterization of peptide-oligonucleotide heteroconjugates by mass spectrometry Nucleic Acids Research. 24: 3866-3872. PMID 8871569 DOI: 10.1093/nar/24.19.3866  0.68
1996 Arttamangkul S, Arbogast B, Barofsky D, Aldrich JV. Characterization of synthetic peptide byproducts from cyclization reactions using on-line HPLC-ion spray and tandem mass spectrometry International Journal of Peptide Research and Therapeutics. 3: 357-370.  0.68
1995 Arttamangkul S, Murray TF, DeLander GE, Aldrich JV. Synthesis and opioid activity of conformationally constrained dynorphin A analogues. 1. Conformational constraint in the "message" sequence Journal of Medicinal Chemistry. 38: 2410-2417. PMID 7608905  0.68
1993 Snyder KR, Murray TF, DeLander GE, Aldrich JV. Synthesis and opioid activity of dynorphin A-(1-13)NH2 analogues containing cis- and trans-4-aminocyclohexanecarboxylic acid Journal of Medicinal Chemistry. 36: 1100-1103. PMID 8097539  0.68
1992 Choi H, Murray TF, DeLander GE, Caldwell V, Aldrich JV. N-terminal alkylated derivatives of [D-Pro10]dynorphin A-(1-11) are highly selective for κ-opioid receptors Journal of Medicinal Chemistry. 35: 4638-4639. PMID 1361580  0.68
1992 Snyder KR, Story SC, Heidt ME, Murray TF, DeLander GE, Aldrich JV. Effect of modification of the basic residues of dynorphin A-(1-13) amide on κ opioid receptor selectivity and opioid activity Journal of Medicinal Chemistry. 35: 4330-4333. PMID 1360025 DOI: 10.1021/jm00101a010  0.68
1992 Story SC, Murray TF, Delander GE, Aldrich JV. Synthesis and opioid activity of 2-substituted dynorphin A-(1-13) amide analogues International Journal of Peptide and Protein Research. 40: 89-96. PMID 1359999  0.44
1987 Lovett JA, Portoghese PS. Synthesis and evaluation of melphalan-containing N,N-dialkylenkephalin analogues as irreversible antagonists of the delta opioid receptor. Journal of Medicinal Chemistry. 30: 1668-74. PMID 3041000  0.76
1987 Lovett JA, Portoghese PS. N,N-dialkylated leucine enkephalins as potential delta opioid receptor antagonists. Journal of Medicinal Chemistry. 30: 1144-9. PMID 3037078  0.8
1986 Lovett JA, Portoghese PS. Melphalan-containing N,N-dialkylenkephalin analogs as potential irreversible antagonists of the delta opioid receptor. Nida Research Monograph. 75: 185-8. PMID 2828969  0.56
1985 Darby MV, Lovett JA, Brueggemeier RW, Groziak MP, Counsell RE. 7 alpha-substituted derivatives of androstenedione as inhibitors of estrogen biosynthesis. Journal of Medicinal Chemistry. 28: 803-7. PMID 4009603 DOI: 10.1021/jm00383a019  0.2
1984 Lovett JA, Darby MV, Counsell RE. Synthesis and evaluation of 19-aza- and 19-aminoandrostenedione analogues as potential aromatase inhibitors. Journal of Medicinal Chemistry. 27: 734-40. PMID 6547488  0.52
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