Linda J. Pike - Publications

Affiliations: 
Biology & Biomedical Sciences (Biochemistry) Washington University, Saint Louis, St. Louis, MO 
Area:
Biochemistry, Cell Biology

78 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Ronan T, Macdonald-Obermann JL, Huelsmann L, Bessman NJ, Naegle KM, Pike LJ. Different Epidermal Growth Factor Receptor (EGFR) Agonists Produce Unique Signatures for the Recruitment of Downstream Signaling Proteins. The Journal of Biological Chemistry. 291: 5528-40. PMID 26786109 DOI: 10.1074/Jbc.M115.710087  1
2014 Macdonald-Obermann JL, Pike LJ. Different epidermal growth factor (EGF) receptor ligands show distinct kinetics and biased or partial agonism for homodimer and heterodimer formation. The Journal of Biological Chemistry. 289: 26178-88. PMID 25086039 DOI: 10.1074/Jbc.M114.586826  1
2013 Macdonald-Obermann JL, Adak S, Landgraf R, Piwnica-Worms D, Pike LJ. Dynamic analysis of the epidermal growth factor (EGF) receptor-ErbB2-ErbB3 protein network by luciferase fragment complementation imaging. The Journal of Biological Chemistry. 288: 30773-84. PMID 24014028 DOI: 10.1074/Jbc.M113.489534  1
2012 Li Y, Macdonald-Obermann J, Westfall C, Piwnica-Worms D, Pike LJ. Quantitation of the effect of ErbB2 on epidermal growth factor receptor binding and dimerization. The Journal of Biological Chemistry. 287: 31116-25. PMID 22822073 DOI: 10.1074/Jbc.M112.373647  1
2012 Pike LJ. Negative co-operativity in the EGF receptor. Biochemical Society Transactions. 40: 15-9. PMID 22260659 DOI: 10.1042/Bst20110610  1
2012 Macdonald-Obermann JL, Piwnica-Worms D, Pike LJ. Mechanics of EGF receptor/ErbB2 kinase activation revealed by luciferase fragment complementation imaging. Proceedings of the National Academy of Sciences of the United States of America. 109: 137-42. PMID 22190492 DOI: 10.1073/Pnas.1111316109  1
2011 Adak S, Yang KS, Macdonald-Obermann J, Pike LJ. The membrane-proximal intracellular domain of the epidermal growth factor receptor underlies negative cooperativity in ligand binding. The Journal of Biological Chemistry. 286: 45146-55. PMID 22069315 DOI: 10.1074/Jbc.M111.274175  1
2011 Adak S, DeAndrade D, Pike LJ. The tethering arm of the EGF receptor is required for negative cooperativity and signal transduction. The Journal of Biological Chemistry. 286: 1545-55. PMID 21047778 DOI: 10.1074/Jbc.M110.182899  1
2010 Yang KS, Macdonald-Obermann JL, Piwnica-Worms D, Pike LJ. Asp-960/Glu-961 controls the movement of the C-terminal tail of the epidermal growth factor receptor to regulate asymmetric dimer formation. The Journal of Biological Chemistry. 285: 24014-22. PMID 20507979 DOI: 10.1074/Jbc.M110.103317  1
2010 Yang RY, Yang KS, Pike LJ, Marshall GR. Targeting the dimerization of epidermal growth factor receptors with small-molecule inhibitors. Chemical Biology & Drug Design. 76: 1-9. PMID 20456371 DOI: 10.1111/J.1747-0285.2010.00986.X  1
2009 Macdonald-Obermann JL, Pike LJ. The intracellular juxtamembrane domain of the epidermal growth factor (EGF) receptor is responsible for the allosteric regulation of EGF binding. The Journal of Biological Chemistry. 284: 13570-6. PMID 19336395 DOI: 10.1074/Jbc.M109.001487  1
2009 Macdonald-Obermann JL, Pike LJ. Palmitoylation of the EGF receptor impairs signal transduction and abolishes high-affinity ligand binding. Biochemistry. 48: 2505-13. PMID 19196031 DOI: 10.1021/Bi802249X  1
2009 Yang KS, Ilagan MX, Piwnica-Worms D, Pike LJ. Luciferase fragment complementation imaging of conformational changes in the epidermal growth factor receptor. The Journal of Biological Chemistry. 284: 7474-82. PMID 19171934 DOI: 10.1074/Jbc.M808041200  1
2009 Pike LJ. The challenge of lipid rafts. Journal of Lipid Research. 50: S323-8. PMID 18955730 DOI: 10.1194/Jlr.R800040-Jlr200  1
2008 Eiblmaier M, Meyer LA, Watson MA, Fracasso PM, Pike LJ, Anderson CJ. Correlating EGFR expression with receptor-binding properties and internalization of 64Cu-DOTA-cetuximab in 5 cervical cancer cell lines. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 49: 1472-9. PMID 18703609 DOI: 10.2967/Jnumed.108.052316  1
2008 Macdonald JL, Pike LJ. Heterogeneity in EGF-binding affinities arises from negative cooperativity in an aggregating system. Proceedings of the National Academy of Sciences of the United States of America. 105: 112-7. PMID 18165319 DOI: 10.1073/Pnas.0707080105  1
2008 Macdonald JL, Pike LJ. Heterogeneity in EGF-binding affinities arises from negative cooperativity in an aggregating system (Proceedings of the National Academy of Sciences of the United States of America (2008) 105, (112-117) DOI:10.1073/pnas.0707080105) Proceedings of the National Academy of Sciences of the United States of America. 105: 9129. DOI: 10.1073/Pnas.0804457105  1
2006 Macdonald J, Li Z, Su W, Pike LJ. The membrane proximal disulfides of the EGF receptor extracellular domain are required for high affinity binding and signal transduction but do not play a role in the localization of the receptor to lipid rafts. Biochimica Et Biophysica Acta. 1763: 870-8. PMID 16842869 DOI: 10.1016/J.Bbamcr.2006.05.002  1
2006 Pike LJ. Rafts defined: a report on the Keystone Symposium on Lipid Rafts and Cell Function. Journal of Lipid Research. 47: 1597-8. PMID 16645198 DOI: 10.1194/Jlr.E600002-Jlr200  1
2005 Mejia R, Olivero O, Rivera-Goba M, Anders A, Caban C, Leon-Monzon M, Marquez E. Asian scientists and the "glass ceiling". Science (New York, N.Y.). 310: 1767-8. PMID 16363026  1
2005 Pike LJ. Growth factor receptors, lipid rafts and caveolae: an evolving story. Biochimica Et Biophysica Acta. 1746: 260-73. PMID 15951036 DOI: 10.1016/J.Bbamcr.2005.05.005  1
2005 Pike LJ, Han X, Gross RW. Epidermal growth factor receptors are localized to lipid rafts that contain a balance of inner and outer leaflet lipids: a shotgun lipidomics study. The Journal of Biological Chemistry. 280: 26796-804. PMID 15917253 DOI: 10.1074/Jbc.M503805200  1
2005 Macdonald JL, Pike LJ. A simplified method for the preparation of detergent-free lipid rafts. Journal of Lipid Research. 46: 1061-7. PMID 15722565 DOI: 10.1194/Jlr.D400041-Jlr200  1
2004 Pike LJ. Lipid rafts: heterogeneity on the high seas. The Biochemical Journal. 378: 281-92. PMID 14662007 DOI: 10.1042/Bj20031672  1
2003 Westover EJ, Covey DF, Brockman HL, Brown RE, Pike LJ. Cholesterol depletion results in site-specific increases in epidermal growth factor receptor phosphorylation due to membrane level effects. Studies with cholesterol enantiomers. The Journal of Biological Chemistry. 278: 51125-33. PMID 14530278 DOI: 10.1074/Jbc.M304332200  1
2003 Pike LJ. Lipid rafts: bringing order to chaos. Journal of Lipid Research. 44: 655-67. PMID 12562849 DOI: 10.1194/Jlr.R200021-Jlr200  1
2003 Pike LJ. Role of Lipid Domains in EGF Receptor Signaling Handbook of Cell Signaling. 1: 323-326. DOI: 10.1016/B978-012124546-7/50418-6  1
2002 Pike LJ, Casey L. Cholesterol levels modulate EGF receptor-mediated signaling by altering receptor function and trafficking. Biochemistry. 41: 10315-22. PMID 12162747 DOI: 10.1021/Bi025943I  1
2002 Sun J, Nanjundan M, Pike LJ, Wiedmer T, Sims PJ. Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor. Biochemistry. 41: 6338-45. PMID 12009895 DOI: 10.1021/Bi025610L  1
2002 Pike LJ, Han X, Chung KN, Gross RW. Lipid rafts are enriched in arachidonic acid and plasmenylethanolamine and their composition is independent of caveolin-1 expression: a quantitative electrospray ionization/mass spectrometric analysis. Biochemistry. 41: 2075-88. PMID 11827555 DOI: 10.1021/Bi0156557  1
2001 Loussouarn G, Pike LJ, Ashcroft FM, Makhina EN, Nichols CG. Dynamic sensitivity of ATP-sensitive K(+) channels to ATP. The Journal of Biological Chemistry. 276: 29098-103. PMID 11395495 DOI: 10.1074/Jbc.M102365200  1
1998 Pike LJ, Miller JM. Cholesterol depletion delocalizes phosphatidylinositol bisphosphate and inhibits hormone-stimulated phosphatidylinositol turnover Journal of Biological Chemistry. 273: 22298-22304. PMID 9712847 DOI: 10.1074/Jbc.273.35.22298  1
1998 Liu Y, Casey L, Pike LJ. Compartmentalization of phosphatidylinositol 4,5-bisphosphate in low-density membrane domains in the absence of caveolin Biochemical and Biophysical Research Communications. 245: 684-690. PMID 9588175 DOI: 10.1006/Bbrc.1998.8329  1
1998 Pike LJ, Lia Y, Chung KN, Heuser JY. Phosphoinositides in detergent-resistant membrane domains Faseb Journal. 12.  1
1997 Pandit SD, O'Hare T, Donis-Keller H, Pike LJ. Functional characterization of an epidermal growth factor receptor/RET chimera Journal of Biological Chemistry. 272: 2199-2206. PMID 8999923 DOI: 10.1074/Jbc.272.4.2199  1
1996 Pike LJ, Casey L. Localization and turnover of phosphatidylinositol 4,5-bisphosphate in caveolin-enriched membrane domains Journal of Biological Chemistry. 271: 26453-26456. PMID 8900109 DOI: 10.1074/Jbc.271.43.26453  1
1996 Hope HR, Pike LJ. Phosphoinositides and phosphoinositide-utilizing enzymes in detergent- insoluble lipid domains Molecular Biology of the Cell. 7: 843-851. PMID 8816992 DOI: 10.1091/Mbc.7.6.843  1
1996 Pandit SD, Donis-Kellert H, Iwamoto T, Tomich JM, Pike LJ. The multiple endocrine neoplasia type 2B point mutation alters long-term regulation and enhances the transforming capacity of the epidermal growth factor receptor Journal of Biological Chemistry. 271: 5850-5858. PMID 8621456 DOI: 10.1074/Jbc.271.10.5850  1
1995 Newberry EP, Pike LJ. Cell-cycle-dependent modulation of EGF-receptor-mediated signaling Biochemical and Biophysical Research Communications. 208: 253-259. PMID 7887936 DOI: 10.1006/Bbrc.1995.1331  1
1994 Rath Hope HM, Pike LJ. Purification and characterization of a polyphosphoinositide phosphatase from rat brain Journal of Biological Chemistry. 269: 23648-23654. PMID 8089134  1
1994 Schuh SM, Newberry EP, Dalton MA, Pike LJ. Mutation of proline-1003 to glycine in the epidermal growth factor (EGF) receptor enhances responsiveness to EGF. Molecular Biology of the Cell. 5: 739-46. PMID 7812043 DOI: 10.1091/Mbc.5.7.739  1
1993 Kuppuswamy D, Dalton M, Pike LJ. Serine 1002 is a site of in vivo and in vitro phosphorylation of the epidermal growth factor receptor Journal of Biological Chemistry. 268: 19134-19142. PMID 8360196  1
1992 Pike LJ. Dimer formation and desensitization of the epidermal growth factor receptor The Journal of Laboratory and Clinical Medicine. 120: 688-692. PMID 1431496  1
1992 Spizz G, Pike LJ. Growth factors promote inositol uptake in BC3H1 cells Biochemical and Biophysical Research Communications. 182: 1008-1015. PMID 1311564 DOI: 10.1016/0006-291X(92)91832-B  1
1992 Pike LJ. Phosphatidylinositol 4-kinases and the role of polyphosphoinositides in cellular regulation Endocrine Research. 18: 692-706. DOI: 10.1210/Edrv-13-4-692  1
1991 Kuppuswamy D, Pike LJ. Desensitization of the EGF receptor alters its ability to undergo EGF-induced dimerization Cellular Signalling. 3: 107-117. PMID 1878288 DOI: 10.1016/0898-6568(91)90017-O  1
1991 Dadabay CY, Patton E, Cooper JA, Pike LJ. Lack of correlation between changes in polyphosphoinositide levels and actin/gelsolin complexes in A431 cells treated with epidermal growth factor Journal of Cell Biology. 112: 1151-1156. PMID 1847932 DOI: 10.1083/Jcb.112.6.1151  1
1990 Walker DH, Pike LJ. Stimulation of purified phosphatidylinositol 4-kinase by cobra venom cardiotoxin Bba - Molecular Cell Research. 1055: 295-298. PMID 2176108 DOI: 10.1016/0167-4889(90)90046-G  1
1989 Dadabay CY, Pike LJ. Purification and characterization of a cytosolic transglutaminase from a cultured human tumour-cell line Biochemical Journal. 264: 679-685. PMID 2575900 DOI: 10.1042/Bj2640679  1
1989 Cunningham TW, Kuppuswamy D, Pike LJ. Treatment of A431 cells with epidermal growth factor (EGF) induces desensitization of EGF-stimulated phosphatidylinositol turnover. The Journal of Biological Chemistry. 264: 15351-6. PMID 2549060  1
1989 Kuppuswamy D, Pike LJ. Ligand-induced desensitization of 125I-epidermal growth factor internalization Journal of Biological Chemistry. 264: 3357-3363. PMID 2492535  1
1988 Walker DH, Dougherty N, Pike LJ. Purification and characterization of a phosphatidylinositol kinase from A431 cells Biochemistry. 27: 6504-6511. PMID 2851325 DOI: 10.1021/Bi00417A046  1
1987 Pike LJ. [33] Assay of growth factor-stimulated tyrosine kinases using synthetic peptide substrates Methods in Enzymology. 146: 353-362. PMID 3683208 DOI: 10.1016/S0076-6879(87)46036-9  1
1987 Walker DH, Kuppuswamy D, Visvanathan A, Pike LJ. Substrate specificity and kinetic mechanism of human placental insulin receptor/kinase. Biochemistry. 26: 1428-33. PMID 3567178 DOI: 10.1021/Bi00379A033  1
1987 Dadabay CY, Pike LJ. Rapid increases in the transglutaminase activity of A431 cells following treatment with epidermal growth factor Biochemistry. 26: 6587-6591. PMID 2892526 DOI: 10.1021/Bi00395A004  1
1987 Walker DH, Pike LJ. Phosphatidylinositol kinase is activated in membranes derived from cells treated with epidermal growth factor Proceedings of the National Academy of Sciences of the United States of America. 84: 7513-7517. PMID 2823265 DOI: 10.1073/Pnas.84.21.7513  1
1987 Pike LJ, Eakes AT. Epidermal growth factor stimulates the production of phosphatidylinositol monophosphate and the breakdown of polyphosphoinositides in A431 cells Journal of Biological Chemistry. 262: 1644-1651. PMID 2433285  1
1986 Stefanovic D, Erikson E, Pike LJ, Maller JL. Activation of a ribosomal protein S6 protein kinase in Xenopus oocytes by insulin and insulin-receptor kinase. The Embo Journal. 5: 157-60. PMID 3514207 DOI: 10.1002/J.1460-2075.1986.Tb04190.X  1
1986 Maller JL, Pike LJ, Freidenberg GR, Cordera R, Stith BJ, Olefsky JM, Krebs EG. Increased phosphorylation of ribosomal protein S6 following microinjection of insulin receptor-kinase into Xenopus oocytes. Nature. 320: 459-61. PMID 3083266 DOI: 10.1038/320459a0  1
1986 Pike LJ, Eakes AT, Krebs EG. Characterization of affinity-purified insulin receptor/kinase. Effects of dithiothreitol on receptor/kinase function. The Journal of Biological Chemistry. 261: 3782-9. PMID 3005300  1
1986 Eide BL, Krebs EG, Ross R, Pike LJ, Bowen-Pope DF. Tumor promoter enhances mitogenesis by PDGF with little effect on PDGF binding. Journal of Cellular Physiology. 126: 254-8. PMID 3003126 DOI: 10.1002/Jcp.1041260215  1
1985 Benovic JL, Pike LJ, Cerione RA, Staniszewski C, Yoshimasa T, Codina J, Caron MG, Lefkowitz RJ. Phosphorylation of the mammalian β-adrenergic receptor by cyclic AMP-dependent protein kinase. Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist occupancy and effects on coupling of the receptor to the stimulatory guanine nucleotide regulatory protein Journal of Biological Chemistry. 260: 7094-7101. PMID 2987243  1
1984 Pike LJ, Kuenzel EA, Casnellie JE, Krebs EG. A comparison of the insulin- and epidermal growth factor-stimulated protein kinases from human placenta. The Journal of Biological Chemistry. 259: 9913-21. PMID 6378914  1
1984 Pike LJ, Benovic JL, Caron MG, Lefkowitz RJ. Isoproterenol enhances phosphorylation of pure β-adrenergic receptor by cAMP-dependent protein kinase Federation Proceedings. 43.  1
1983 Cassel D, Pike LJ, Grant GA, Krebs EG, Glaser L. Interaction of epidermal growth factor-dependent protein kinase with endogenous membrane proteins and soluble peptide substrate. The Journal of Biological Chemistry. 258: 2945-50. PMID 6298213  1
1983 Pike LJ, Bowen-Pope DF, Ross R, Krebs EG. Characterization of platelet-derived growth factor-stimulated phosphorylation in cell membranes. The Journal of Biological Chemistry. 258: 9383-90. PMID 6192129  1
1982 Pike LJ, Marquardt H, Todaro GJ, Gallis B, Casnellie JE, Bornstein P, Krebs EG. Transforming growth factor and epidermal growth factor stimulate the phosphorylation of a synthetic, tyrosine-containing peptide in a similar manner. The Journal of Biological Chemistry. 257: 14628-31. PMID 6983525  1
1982 Casnellie JE, Harrison ML, Pike LJ, Hellström KE, Krebs EG. Phosphorylation of synthetic peptides by a tyrosine protein kinase from the particulate fraction of a lymphoma cell line. Proceedings of the National Academy of Sciences of the United States of America. 79: 282-6. PMID 6804939 DOI: 10.1073/Pnas.79.2.282  1
1982 Pike LJ, Gallis B, Casnellie JE, Bornstein P, Krebs EG. Epidermal growth factor stimulates the phosphorylation of synthetic tyrosine-containing peptides by A431 cell membranes. Proceedings of the National Academy of Sciences of the United States of America. 79: 1443-7. PMID 6175968 DOI: 10.1073/Pnas.79.5.1443  1
1981 Pike LJ, Lefkowitz RJ. Correlation of β-adrenergic receptor-stimulated [3H]GDP release and adenylate cyclase activation. Differences between frog and turkey erythrocyte membranes Journal of Biological Chemistry. 256: 2207-2212. PMID 6257708  1
1980 Pike LJ, Lefkowitz RJ. Use of cell fusion techniques to probe the mechanism of catecholamine induced desensitization of adenylate cyclase in frog erythrocytes Biochimica Et Biophysica Acta. 632: 354-365. PMID 6251915 DOI: 10.1016/0304-4165(80)90231-7  1
1980 Pike LJ, Lefkowitz RJ. Activation and desensitization of β-adrenergic receptor-coupled GTPase and adenylate cyclase of frog and turkey erythrocyte membranes Journal of Biological Chemistry. 255: 6860-6867. PMID 6104667  1
1979 Limbird LE, DeLean A, Hickey AR, Pike LJ, Lefkowitz RJ. Differential effects of GTP on the coupling of beta-adrenergic receptors to adenylate cyclase from frog and turkey erythrocytes. Application of new methods for the analysis of receptor-effector coupling. Biochimica Et Biophysica Acta. 586: 298-314. PMID 224939 DOI: 10.1016/0304-4165(79)90101-6  1
1979 Pike LJ, Limbird LE, Lefkowitz RJ. Beta-adrenoreceptors determine affinity but not intrinsic activity of adenylate cyclase stimulants. Nature. 280: 502-4. PMID 37448 DOI: 10.1038/280502A0  1
1979 Pike LJ, Lefkowitz RJ. Beta-adrenergic receptors determine affinity but not intrinsic activity of drugs Federation Proceedings. 38.  1
1978 Pike LJ, Lefkowitz RJ. Multiple effects of N,N' dicyclohexyl carbodiimide on the beta-adrenergic receptor adenylate cyclase system in frog erythrocytes Journal of Cyclic Nucleotide Research. 4: 27-34. PMID 205559  1
1978 Pike LJ, Lefkowitz RJ. Agonist-specific alterations in receptor binding affinity associated with solubilization of turkey erythrocyte membrane beta adrenergic receptors Molecular Pharmacology. 14: 370-375. PMID 25377  1
1978 Pike LJ. Multiple effects of N,N' dicyclohexyl carbodiimide on the beta-adrenergic receptor - adenylate cyclase system in frog erythrocytes Federation Proceedings. 37.  1
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