Ryan J. Holland, Ph.D. - Publications

Affiliations: 
2009 Biochemistry University of Maryland, Baltimore County 
Area:
Biochemistry, Organic Chemistry

20 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Kim Y, Maciag AE, Cao Z, Deschamps JR, Saavedra JE, Keefer LK, Holland RJ. PABA/NO lead optimization: Improved targeting of cytotoxicity to glutathione S-transferase P1-overexpressing cancer cells. Bioorganic & Medicinal Chemistry. 23: 4980-8. PMID 26043946 DOI: 10.1016/J.Bmc.2015.05.020  0.44
2015 Kus K, Walczak M, Maslak E, Zakrzewska A, Gonciarz-Dytman A, Zabielski P, Sitek B, Wandzel K, Kij A, Chabowski A, Holland RJ, Saavedra JE, Keefer LK, Chlopicki S. Hepatoselective Nitric Oxide (NO) Donors, V-PYRRO/NO and V-PROLI/NO, in Nonalcoholic Fatty Liver Disease: A Comparison of Antisteatotic Effects with the Biotransformation and Pharmacokinetics. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 43: 1028-36. PMID 25870102 DOI: 10.1124/dmd.115.063388  0.44
2015 Maslak E, Zabielski P, Kochan K, Kus K, Jasztal A, Sitek B, Proniewski B, Wojcik T, Gula K, Kij A, Walczak M, Baranska M, Chabowski A, Holland RJ, Saavedra JE, et al. The liver-selective NO donor, V-PYRRO/NO, protects against liver steatosis and improves postprandial glucose tolerance in mice fed high fat diet. Biochemical Pharmacology. 93: 389-400. PMID 25534988 DOI: 10.1016/J.Bcp.2014.12.004  0.44
2014 Holland RJ, Klose JR, Deschamps JR, Cao Z, Keefer LK, Saavedra JE. Direct reaction of amides with nitric oxide to form diazeniumdiolates. The Journal of Organic Chemistry. 79: 9389-93. PMID 25210948 DOI: 10.1021/Jo501670E  0.44
2014 Biswas D, Hrabie JA, Saavedra JE, Cao Z, Keefer LK, Ivanic J, Holland RJ. Aminolysis of an N-diazeniumdiolated amidine as an approach to diazeniumdiolated ammonia. The Journal of Organic Chemistry. 79: 4512-6. PMID 24766285 DOI: 10.1021/Jo500551N  0.44
2014 Maciag AE, Holland RJ, Kim Y, Kumari V, Luthers CE, Sehareen WS, Biswas D, Morris NL, Ji X, Anderson LM, Saavedra JE, Keefer LK. Nitric oxide (NO) releasing poly ADP-ribose polymerase 1 (PARP-1) inhibitors targeted to glutathione S-transferase P1-overexpressing cancer cells. Journal of Medicinal Chemistry. 57: 2292-302. PMID 24521039 DOI: 10.1021/Jm401550D  0.44
2014 Kaczmarek MZ, Holland RJ, Lavanier SA, Troxler JA, Fesenkova VI, Hanson CA, Cmarik JL, Saavedra JE, Keefer LK, Ruscetti SK. Mechanism of action for the cytotoxic effects of the nitric oxide prodrug JS-K in murine erythroleukemia cells. Leukemia Research. 38: 377-82. PMID 24461365 DOI: 10.1016/J.Leukres.2013.12.002  0.44
2013 Holland RJ, Paulisch R, Cao Z, Keefer LK, Saavedra JE, Donzelli S. Enzymatic generation of the NO/HNO-releasing IPA/NO anion at controlled rates in physiological media using β-galactosidase. Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. 35: 131-6. PMID 24126017 DOI: 10.1016/J.Niox.2013.10.003  0.44
2013 Basudhar D, Bharadwaj G, Cheng RY, Jain S, Shi S, Heinecke JL, Holland RJ, Ridnour LA, Caceres VM, Spadari-Bratfisch RC, Paolocci N, Velázquez-Martínez CA, Wink DA, Miranda KM. Synthesis and chemical and biological comparison of nitroxyl- and nitric oxide-releasing diazeniumdiolate-based aspirin derivatives. Journal of Medicinal Chemistry. 56: 7804-20. PMID 24102516 DOI: 10.1021/Jm400196Q  0.44
2013 Maciag AE, Holland RJ, Robert Cheng YS, Rodriguez LG, Saavedra JE, Anderson LM, Keefer LK. Nitric oxide-releasing prodrug triggers cancer cell death through deregulation of cellular redox balance. Redox Biology. 1: 115-24. PMID 24024144 DOI: 10.1016/J.Redox.2012.12.002  0.44
2013 Wang YN, Collins J, Holland RJ, Keefer LK, Ivanic J. Decoding nitric oxide release rates of amine-based diazeniumdiolates. The Journal of Physical Chemistry. A. 117: 6671-7. PMID 23834533 DOI: 10.1021/Jp404589P  0.44
2012 Maciag AE, Holland RJ, Saavedra JE, Chakrapani H, Shami PJ, Keefer LK. Thiol Modification By Pharmacologically Active Agents of the Diazeniumdiolate Class. Forum On Immunopathological Diseases and Therapeutics. 3: 91-95. PMID 23585982 DOI: 10.1615/Forumimmundisther.2012006334  0.44
2012 Biswas D, Holland RJ, Deschamps JR, Cao Z, Keefer LK, Saavedra JE. O2-functionalized methylamine diazeniumdiolates: evidence for E ⇄ Z equilibration in an acyclic system. The Journal of Organic Chemistry. 77: 10804-10. PMID 23137026 DOI: 10.1021/Jo3020837  0.44
2012 Holland RJ, Maciag AE, Kumar V, Shi L, Saavedra JE, Prud'homme RK, Chakrapani H, Keefer LK. Cross-linking protein glutathionylation mediated by O2-arylated bis-diazeniumdiolate "Double JS-K". Chemical Research in Toxicology. 25: 2670-7. PMID 23106594 DOI: 10.1021/Tx3003142  0.44
2012 Nandurdikar RS, Maciag AE, Holland RJ, Cao Z, Shami PJ, Anderson LM, Keefer LK, Saavedra JE. Structural modifications modulate stability of glutathione-activated arylated diazeniumdiolate prodrugs. Bioorganic & Medicinal Chemistry. 20: 3094-9. PMID 22480849 DOI: 10.1016/J.Bmc.2012.02.045  0.44
2011 Maciag AE, Chakrapani H, Saavedra JE, Morris NL, Holland RJ, Kosak KM, Shami PJ, Anderson LM, Keefer LK. The nitric oxide prodrug JS-K is effective against non-small-cell lung cancer cells in vitro and in vivo: involvement of reactive oxygen species. The Journal of Pharmacology and Experimental Therapeutics. 336: 313-20. PMID 20962031 DOI: 10.1124/Jpet.110.174904  0.44
2010 Oladeinde OA, Hong SY, Holland RJ, Maciag AE, Keefer LK, Saavedra JE, Nandurdikar RS. "Click" reaction in conjunction with diazeniumdiolate chemistry: developing high-load nitric oxide donors. Organic Letters. 12: 4256-9. PMID 20812718 DOI: 10.1021/Ol101645K  0.44
2010 Holland R, Fishbein JC. Chemistry of the cysteine sensors in Kelch-like ECH-associated protein 1. Antioxidants & Redox Signaling. 13: 1749-61. PMID 20486763 DOI: 10.1089/Ars.2010.3273  0.44
2009 Holland R, Navamal M, Velayutham M, Zweier JL, Kensler TW, Fishbein JC. Hydrogen peroxide is a second messenger in phase 2 enzyme induction by cancer chemopreventive dithiolethiones. Chemical Research in Toxicology. 22: 1427-34. PMID 19785463 DOI: 10.1021/Tx900110N  0.44
2008 Holland R, Hawkins AE, Eggler AL, Mesecar AD, Fabris D, Fishbein JC. Prospective type 1 and type 2 disulfides of Keap1 protein. Chemical Research in Toxicology. 21: 2051-60. PMID 18729328 DOI: 10.1021/Tx800226M  0.44
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