Trevor M. Penning - Publications

Affiliations: 
Pharmacology, Biochemistry & Biophysics University of Pennsylvania School of Medicine, Philadelphia, PA, United States 
Area:
enzymology of steroid hormones

273 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Murray JR, Mesaros CA, Arlt VM, Seidel A, Blair IA, Penning TM. Correction to "Role of Human Aldo-Keto Reductases in the Metabolic Activation of the Carcinogenic Air Pollutant 3-Nitrobenzanthrone". Chemical Research in Toxicology. PMID 31663337 DOI: 10.1021/acs.chemrestox.9b00420  0.44
2019 Chen M, Wangtrakuldee P, Zang T, Duan L, Gathercole LL, Tomlinson JW, Penning TM. Human and murine steroid 5β-reductases (AKR1D1 and AKR1D4): insights into the role of the catalytic glutamic acid. Chemico-Biological Interactions. PMID 30928400 DOI: 10.1016/j.cbi.2019.03.025  0.68
2019 Verma K, Zang T, Penning TM, Trippier PC. Potent and Highly Selective Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors Act as Chemotherapeutic Potentiators in Acute Myeloid Leukemia and T-Cell Acute Lymphoblastic Leukemia. Journal of Medicinal Chemistry. PMID 30836001 DOI: 10.1021/acs.jmedchem.9b00090  0.36
2019 Wangtrakuldee P, Adeniji AO, Zang T, Duan L, Khatri B, Twenter BM, Estrada MA, Higgins TF, Winkler JD, Penning TM. A 3-(4-Nitronaphthen-1-yl) amino-benzoate analog as a Bifunctional AKR1C3 Inhibitor with AR Antagonist Activity: Head to Head Comparison with Other Advanced AKR1C3 Targeted Therapeutics. The Journal of Steroid Biochemistry and Molecular Biology. PMID 30641225 DOI: 10.1016/j.jsbmb.2019.01.001  0.72
2018 Murray JR, Mesaros CA, Arlt VM, Seidel A, Blair IA, Penning TM. Role of Human Aldo-Keto Reductases in the Metabolic Activation of the Carcinogenic Air Pollutant 3-Nitrobenzanthrone. Chemical Research in Toxicology. PMID 30406992 DOI: 10.1021/acs.chemrestox.8b00250  0.44
2018 Mostaghel EA, Zhang A, Hernandez S, Marck B, Zhang X, Tamae D, Biehl H, Tretiakova MS, Bartlett J, Burns JF, Dumpit RF, Ang LS, Matsumoto AM, Penning TM, Balk SP, et al. Contribution of Adrenal Glands to Intra-tumor Androgens and Growth of Castration Resistant Prostate Cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30181386 DOI: 10.1158/1078-0432.CCR-18-1431  1
2018 Penning TM, Wangtrakuldee P, Auchus RJ. Structural and Functional Biology of Aldo-Keto Reductase Steroid Transforming Enzymes. Endocrine Reviews. PMID 30137266 DOI: 10.1210/er.2018-00089  0.36
2018 Verma K, Gupta N, Zang T, Wangtrakuldee P, Srivastava SK, Penning TM, Trippier PC. AKR1C3 Inhibitor KV-37 Exhibits Antineoplastic Effects and Potentiates Enzalutamide in Combination Therapy in Prostate Adenocarcinoma Cells. Molecular Cancer Therapeutics. PMID 29891491 DOI: 10.1158/1535-7163.MCT-17-1023  0.36
2017 Huang J, Liu Y, Vitale S, Penning TM, Whitehead AS, Blair IA, Vachani A, Clapper ML, Muscat JE, Lazarus P, Scheet P, Moore JH, Chen Y. On meta- and mega-analyses for gene-environment interactions. Genetic Epidemiology. PMID 29110346 DOI: 10.1002/gepi.22085  0.44
2017 Huang M, Mesaros CA, Hackfield LC, Hodge RP, Blair IA, Penning TM. Potential Metabolic Activation of Representative Alkylated Polycyclic Aromatic Hydrocarbons 1-Methylphenanthrene and 9-Ethylphenanthrene Associated with the Deepwater Horizon Oil Spill in Human Hepatoma (HepG2) Cells. Chemical Research in Toxicology. PMID 29035516 DOI: 10.1021/acs.chemrestox.7b00232  0.44
2017 Zang T, Taplin ME, Tamae D, Xie W, Mesaros C, Zhang Z, Bubley GJ, Montgomery RB, Balk S, Mostaghel E, Blair IA, Penning T. Testicular versus adrenal sources of hydroxyandrogens in prostate cancer. Endocrine-Related Cancer. PMID 28663228 DOI: 10.1530/ERC-17-0107  1
2017 Huang M, Mesaros CA, Hackfield LC, Hodge RP, Zang T, Blair IA, Penning TM. Potential Metabolic Activation of a Representative C4-Alkylated Polycyclic Aromatic Hydrocarbon Retene (1-Methyl-7-isopropyl-phenanthrene) Associated With the Deepwater Horizon Oil Spill in Human Hepatoma (HepG2) Cells. Chemical Research in Toxicology. PMID 28278373 DOI: 10.1021/acs.chemrestox.6b00457  0.44
2016 Verma K, Zang T, Gupta N, Penning TM, Trippier PC. Selective AKR1C3 Inhibitors Potentiate Chemotherapeutic Activity in Multiple Acute Myeloid Leukemia (AML) Cell Lines. Acs Medicinal Chemistry Letters. 7: 774-9. PMID 27563402 DOI: 10.1021/acsmedchemlett.6b00163  0.36
2016 Zang T, Tamae D, Mesaros C, Wang Q, Huang M, Blair IA, Penning TM. Simultaneous Quantitation of Nine Hydroxy-Androgens and Their Conjugates in Human Serum by Stable Isotope Dilution Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry. The Journal of Steroid Biochemistry and Molecular Biology. PMID 27531846 DOI: 10.1016/j.jsbmb.2016.08.001  1
2016 Adeniji AO, Uddin MJ, Zang T, Tamae D, Wangtrakuldee P, Marnett LJ, Penning TM. Discovery of (R)-2-(6-methoxynaphthalen-2-yl)butanoic acid As a Potent and Selective Aldo-keto Reductase 1C3 Inhibitor. Journal of Medicinal Chemistry. PMID 27486833 DOI: 10.1021/acs.jmedchem.6b00160  1
2016 Zanetti KA, Wang Z, Aldrich M, Amos CI, Blot WJ, Bowman ED, Burdette L, Cai Q, Caporaso N, Chung CC, Gillanders EM, Haiman CA, Hansen HM, Henderson BE, Kolonel LN, ... ... Penning TM, et al. Genome-wide association study confirms lung cancer susceptibility loci on chromosomes 5p15 and 15q25 in an African-American population. Lung Cancer (Amsterdam, Netherlands). 98: 33-42. PMID 27393504 DOI: 10.1016/j.lungcan.2016.05.008  1
2016 Penning TM, Tamae D. Current advances in intratumoral androgen metabolism in castration-resistant prostate cancer. Current Opinion in Endocrinology, Diabetes, and Obesity. 23: 264-70. PMID 27119752 DOI: 10.1097/MED.0000000000000253  1
2016 Huang M, Mesaros CA, Zhang S, Blair IA, Penning TM. Potential Metabolic Activation of a Representative C2-Alkylated Polycyclic Aromatic Hydrocarbon (PAH) 6-Ethylchrysene Associated With the Deepwater Horizon Oil Spill in Human Hepatoma (HepG2) Cells. Chemical Research in Toxicology. PMID 27054409 DOI: 10.1021/acs.chemrestox.6b00036  1
2015 Penning TM. Single-molecule enzymology of steroid transforming enzymes: Transient kinetic studies and what they tell us. The Journal of Steroid Biochemistry and Molecular Biology. PMID 26596239 DOI: 10.1016/j.jsbmb.2015.10.016  1
2015 Chen M, Jin Y, Penning TM. IN DEPTH DISSECTION OF THE P133R MUTATION IN STEROID 5β-REDUCTASE (AKR1D1): A MOLECULAR BASIS OF BILE ACID DEFICIENCY. Biochemistry. PMID 26418565 DOI: 10.1021/acs.biochem.5b00816  1
2015 Huang M, Zhang L, Mesaros CA, Hackfield L, Hodge RP, Blair IA, Penning TM. Metabolism of an Alkylated Polycyclic Aromatic Hydrocarbon (PAH) 5-Methylchrysene in Human Hepatoma (HepG2) Cells. Chemical Research in Toxicology. PMID 26395544 DOI: 10.1021/acs.chemrestox.5b00256  1
2015 Hendriks CM, Penning TM, Zang T, Wiemuth D, Gründer S, Sanhueza IA, Schoenebeck F, Bolm C. Pentafluorosulfanyl-containing flufenamic acid analogs: Syntheses, properties and biological activities. Bioorganic & Medicinal Chemistry Letters. PMID 26372652 DOI: 10.1016/j.bmcl.2015.09.012  0.36
2015 Penning TM. Mechanisms of drug resistance that target the androgen axis in castration resistant prostate cancer (CRPC). The Journal of Steroid Biochemistry and Molecular Biology. 153: 105-13. PMID 26032458 DOI: 10.1016/j.jsbmb.2015.05.010  1
2015 Penning TM. Editorial. 17th International Workshop on the Enzymology and Molecular Biology of Carbonyl Metabolism. Chemico-Biological Interactions. 234: 1-3. PMID 25919068 DOI: 10.1016/j.cbi.2015.04.014  1
2015 Jin Y, Chen M, Penning TM, Miller WL. Electron transfer by human wild-type and A287P mutant P450 oxidoreductase assessed by transient kinetics: functional basis of P450 oxidoreductase deficiency. The Biochemical Journal. 468: 25-31. PMID 25728647 DOI: 10.1042/BJ20141410  1
2015 Zang T, Verma K, Chen M, Jin Y, Trippier PC, Penning TM. Screening baccharin analogs as selective inhibitors against type 5 17β-hydroxysteroid dehydrogenase (AKR1C3). Chemico-Biological Interactions. 234: 339-48. PMID 25555457 DOI: 10.1016/j.cbi.2014.12.015  1
2015 Tamae D, Mostaghel E, Montgomery B, Nelson PS, Balk SP, Kantoff PW, Taplin ME, Penning TM. The DHEA-sulfate depot following P450c17 inhibition supports the case for AKR1C3 inhibition in high risk localized and advanced castration resistant prostate cancer. Chemico-Biological Interactions. 234: 332-8. PMID 25514466 DOI: 10.1016/j.cbi.2014.12.012  1
2015 Chen M, Jin Y, Penning TM. The rate-determining steps of aldo-keto reductases (AKRs), a study on human steroid 5β-reductase (AKR1D1). Chemico-Biological Interactions. 234: 360-5. PMID 25500266 DOI: 10.1016/j.cbi.2014.12.004  1
2015 Penning TM, Chen M, Jin Y. Promiscuity and diversity in 3-ketosteroid reductases. The Journal of Steroid Biochemistry and Molecular Biology. 151: 93-101. PMID 25500069 DOI: 10.1016/j.jsbmb.2014.12.003  1
2015 Penning TM. The aldo-keto reductases (AKRs): Overview. Chemico-Biological Interactions. 234: 236-46. PMID 25304492 DOI: 10.1016/j.cbi.2014.09.024  1
2014 Taplin ME, Montgomery B, Logothetis CJ, Bubley GJ, Richie JP, Dalkin BL, Sanda MG, Davis JW, Loda M, True LD, Troncoso P, Ye H, Lis RT, Marck BT, Matsumoto AM, ... ... Penning TM, et al. Intense androgen-deprivation therapy with abiraterone acetate plus leuprolide acetate in patients with localized high-risk prostate cancer: results of a randomized phase II neoadjuvant study. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 32: 3705-15. PMID 25311217 DOI: 10.1200/JCO.2013.53.4578  1
2014 Penning TM. Human aldo-keto reductases and the metabolic activation of polycyclic aromatic hydrocarbons. Chemical Research in Toxicology. 27: 1901-17. PMID 25279998 DOI: 10.1021/tx500298n  1
2014 Penning TM, Breysse PN, Gray K, Howarth M, Yan B. Environmental health research recommendations from the Inter-Environmental Health Sciences Core Center Working Group on unconventional natural gas drilling operations. Environmental Health Perspectives. 122: 1155-9. PMID 25036093 DOI: 10.1289/ehp.1408207  1
2014 Jin Y, Chen M, Penning TM. Rate of steroid double-bond reduction catalysed by the human steroid 5β-reductase (AKR1D1) is sensitive to steroid structure: implications for steroid metabolism and bile acid synthesis. The Biochemical Journal. 462: 163-71. PMID 24894951 DOI: 10.1042/BJ20140220  1
2014 Penning TM. Androgen biosynthesis in castration-resistant prostate cancer. Endocrine-Related Cancer. 21: T67-78. PMID 24829267 DOI: 10.1530/ERC-14-0109  1
2014 Goldstein BD, Brooks BW, Cohen SD, Gates AE, Honeycutt ME, Morris JB, Orme-Zavaleta J, Penning TM, Snawder J. The role of toxicological science in meeting the challenges and opportunities of hydraulic fracturing. Toxicological Sciences : An Official Journal of the Society of Toxicology. 139: 271-83. PMID 24706166 DOI: 10.1093/toxsci/kfu061  1
2014 Huang M, Zhang L, Mesaros C, Zhang S, Blaha MA, Blair IA, Penning TM. Metabolism of a representative oxygenated polycyclic aromatic hydrocarbon (PAH) phenanthrene-9,10-quinone in human hepatoma (HepG2) cells Chemical Research in Toxicology. 27: 852-863. PMID 24646012 DOI: 10.1021/tx500031p  1
2014 Chen M, Penning TM. 5β-Reduced steroids and human Δ(4)-3-ketosteroid 5β-reductase (AKR1D1). Steroids. 83: 17-26. PMID 24513054 DOI: 10.1016/j.steroids.2014.01.013  1
2014 Rižner TL, Penning TM. Role of aldo-keto reductase family 1 (AKR1) enzymes in human steroid metabolism. Steroids. 79: 49-63. PMID 24189185 DOI: 10.1016/j.steroids.2013.10.012  1
2013 Zhang L, Huang M, Blair IA, Penning TM. Interception of benzo[a]pyrene-7,8-dione by UDP glucuronosyltransferases (UGTs) in human lung cells Chemical Research in Toxicology. 26: 1570-1578. PMID 24047243 DOI: 10.1021/tx400268q  1
2013 Tamae D, Byrns M, Marck B, Mostaghel EA, Nelson PS, Lange P, Lin D, Taplin ME, Balk S, Ellis W, True L, Vessella R, Montgomery B, Blair IA, Penning TM. Development, validation and application of a stable isotope dilution liquid chromatography electrospray ionization/selected reaction monitoring/mass spectrometry (SID-LC/ESI/SRM/MS) method for quantification of keto-androgens in human serum. The Journal of Steroid Biochemistry and Molecular Biology. 138: 281-9. PMID 23851165 DOI: 10.1016/j.jsbmb.2013.06.014  1
2013 Adeniji AO, Chen M, Penning TM. AKR1C3 as a target in castrate resistant prostate cancer. The Journal of Steroid Biochemistry and Molecular Biology. 137: 136-49. PMID 23748150 DOI: 10.1016/j.jsbmb.2013.05.012  1
2013 Huang M, Blair IA, Penning TM. Identification of stable benzo[a]pyrene-7,8-dione-DNA adducts in human lung cells Chemical Research in Toxicology. 26: 685-692. PMID 23587017 DOI: 10.1021/tx300476m  1
2013 Liedtke AJ, Adeniji AO, Chen M, Byrns MC, Jin Y, Christianson DW, Marnett LJ, Penning TM. Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer. Journal of Medicinal Chemistry. 56: 2429-46. PMID 23432095 DOI: 10.1021/jm3017656  1
2013 Barski OA, Mindnich R, Penning TM. Alternative splicing in the aldo-keto reductase superfamily: implications for protein nomenclature. Chemico-Biological Interactions. 202: 153-8. PMID 23298867 DOI: 10.1016/j.cbi.2012.12.012  1
2012 Wu A, Xu D, Lu D, Penning TM, Blair IA, Harvey RG. Synthesis of (13) C 4-labelled oxidized metabolites of the carcinogenic polycyclic aromatic hydrocarbon benzo[a]pyrene. Tetrahedron. 68. PMID 24244053 DOI: 10.1016/j.tet.2012.05.130  0.56
2012 Zhang L, Jin Y, Huang M, Penning TM. The Role of Human Aldo-Keto Reductases in the Metabolic Activation and Detoxication of Polycyclic Aromatic Hydrocarbons: Interconversion of PAH Catechols and PAH o-Quinones. Frontiers in Pharmacology. 3: 193. PMID 23162467 DOI: 10.3389/fphar.2012.00193  1
2012 Sinreih M, Sosič I, Beranič N, Turk S, Adeniji AO, Penning TM, Rižner TL, Gobec S. N-Benzoyl anthranilic acid derivatives as selective inhibitors of aldo-keto reductase AKR1C3. Bioorganic & Medicinal Chemistry Letters. 22: 5948-51. PMID 22897946 DOI: 10.1016/j.bmcl.2012.07.062  1
2012 Brožič P, Turk S, Adeniji AO, Konc J, Janežič D, Penning TM, Lanišnik Rižner T, Gobec S. Selective inhibitors of aldo-keto reductases AKR1C1 and AKR1C3 discovered by virtual screening of a fragment library. Journal of Medicinal Chemistry. 55: 7417-24. PMID 22881866 DOI: 10.1021/jm300841n  1
2012 Zhang L, Huang M, Blair IA, Penning TM. Detoxication of benzo[a]pyrene-7,8-dione by sulfotransferases (SULTS) in human lung cells Journal of Biological Chemistry. 287: 29909-29920. PMID 22782890 DOI: 10.1074/jbc.M112.386052  1
2012 Sen S, Bhojnagarwala P, Francey L, Lu D, Penning TM, Field J. p53 Mutagenesis by benzo[a]pyrene derived radical cations. Chemical Research in Toxicology. 25: 2117-26. PMID 22768918 DOI: 10.1021/tx300201p  1
2012 Miller VL, Lin HK, Murugan P, Fan M, Penning TM, Brame LS, Yang Q, Fung KM. Aldo-keto reductase family 1 member C3 (AKR1C3) is expressed in adenocarcinoma and squamous cell carcinoma but not small cell carcinoma. International Journal of Clinical and Experimental Pathology. 5: 278-89. PMID 22670171  1
2012 Chen M, Adeniji AO, Twenter BM, Winkler JD, Christianson DW, Penning TM. Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer. Bioorganic & Medicinal Chemistry Letters. 22: 3492-7. PMID 22507964 DOI: 10.1016/j.bmcl.2012.03.085  1
2012 Huang M, Liu X, Basu SS, Zhang L, Kushman ME, Harvey RG, Blair IA, Penning TM. Metabolism and distribution of benzo[a]pyrene-7,8-dione (B[a]P-7,8-dione) in human lung cells by liquid chromatography tandem mass spectrometry: Detection of an adenine B[a]P-7,8-dione adduct Chemical Research in Toxicology. 25: 993-1003. PMID 22480306 DOI: 10.1021/tx200463s  1
2012 Chen M, Drury JE, Christianson DW, Penning TM. Conversion of human steroid 5β-reductase (AKR1D1) into 3β-hydroxysteroid dehydrogenase by single point mutation E120H: example of perfect enzyme engineering. The Journal of Biological Chemistry. 287: 16609-22. PMID 22437839 DOI: 10.1074/jbc.M111.338780  1
2012 Sun L, Chen Y, Rajendran C, Mueller U, Panjikar S, Wang M, Mindnich R, Rosenthal C, Penning TM, Stöckigt J. Crystal structure of perakine reductase, founding member of a novel aldo-keto reductase (AKR) subfamily that undergoes unique conformational changes during NADPH binding. The Journal of Biological Chemistry. 287: 11213-21. PMID 22334702 DOI: 10.1074/jbc.M111.335521  1
2012 Byrns MC, Mindnich R, Duan L, Penning TM. Overexpression of aldo-keto reductase 1C3 (AKR1C3) in LNCaP cells diverts androgen metabolism towards testosterone resulting in resistance to the 5α-reductase inhibitor finasteride. The Journal of Steroid Biochemistry and Molecular Biology. 130: 7-15. PMID 22265960 DOI: 10.1016/j.jsbmb.2011.12.012  1
2012 Adeniji AO, Twenter BM, Byrns MC, Jin Y, Chen M, Winkler JD, Penning TM. Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase) based on N-phenyl-aminobenzoates and their structure-activity relationships. Journal of Medicinal Chemistry. 55: 2311-23. PMID 22263837 DOI: 10.1021/jm201547v  1
2012 Jin Y, Duan L, Chen M, Penning TM, Kloosterboer HJ. Metabolism of the synthetic progestogen norethynodrel by human ketosteroid reductases of the aldo-keto reductase superfamily. The Journal of Steroid Biochemistry and Molecular Biology. 129: 139-44. PMID 22210085 DOI: 10.1016/j.jsbmb.2011.12.002  1
2012 Gelhaus SL, Gilad O, Hwang WT, Penning TM, Blair IA. Multidrug resistance protein (MRP) 4 attenuates benzo[a]pyrene-mediated DNA-adduct formation in human bronchoalveolar H358 cells Toxicology Letters. 209: 58-66. PMID 22155354 DOI: 10.1016/j.toxlet.2011.11.021  1
2011 Lu D, Harvey RG, Blair IA, Penning TM. Quantitation of benzo[a]pyrene metabolic profiles in human bronchoalveolar (H358) cells by stable isotope dilution liquid chromatography-atmospheric pressure chemical ionization mass spectrometry Chemical Research in Toxicology. 24: 1905-1914. PMID 21962213 DOI: 10.1021/tx2002614  1
2011 Shultz CA, Quinn AM, Park JH, Harvey RG, Bolton JL, Maser E, Penning TM. Specificity of human aldo-keto reductases, NAD(P)H:quinone oxidoreductase, and carbonyl reductases to redox-cycle polycyclic aromatic hydrocarbon diones and 4-hydroxyequilenin-o-quinone. Chemical Research in Toxicology. 24: 2153-66. PMID 21910479 DOI: 10.1021/tx200294c  1
2011 Zhang L, Jin Y, Chen M, Huang M, Harvey RG, Blair IA, Penning TM. Detoxication of structurally diverse Polycyclic Aromatic Hydrocarbon (PAH) o-Quinones by human recombinant catechol-O-methyltransferase (COMT) via O-methylation of PAH catechols Journal of Biological Chemistry. 286: 25644-25654. PMID 21622560 DOI: 10.1074/jbc.M111.240739  1
2011 Akhtar M, Penning TM. Targeted inhibitors for steroid transforming enzymes. The Journal of Steroid Biochemistry and Molecular Biology. 125: 1. PMID 21621737 DOI: 10.1016/j.jsbmb.2011.03.020  1
2011 Penning TM, Adamski J. Integration of steroid research: perspectives on environment factors, homeostasis in health, and disease treatment. The Journal of Steroid Biochemistry and Molecular Biology. 126: e1-4. PMID 21558003 DOI: 10.1016/j.jsbmb.2011.04.011  1
2011 Jin Y, Mesaros AC, Blair IA, Penning TM. Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: Role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway Biochemical Journal. 437: 53-61. PMID 21521174 DOI: 10.1042/BJ20101804  1
2011 Adeniji AO, Twenter BM, Byrns MC, Jin Y, Winkler JD, Penning TM. Discovery of substituted 3-(phenylamino)benzoic acids as potent and selective inhibitors of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3). Bioorganic & Medicinal Chemistry Letters. 21: 1464-8. PMID 21277203 DOI: 10.1016/j.bmcl.2011.01.010  1
2011 Penning TM. Human hydroxysteroid dehydrogenases and pre-receptor regulation: insights into inhibitor design and evaluation. The Journal of Steroid Biochemistry and Molecular Biology. 125: 46-56. PMID 21272640 DOI: 10.1016/j.jsbmb.2011.01.009  1
2011 Chen M, Drury JE, Penning TM. Substrate specificity and inhibitor analyses of human steroid 5β-reductase (AKR1D1). Steroids. 76: 484-90. PMID 21255593 DOI: 10.1016/j.steroids.2011.01.003  1
2011 Mindnich R, Drury JE, Penning TM. The effect of disease associated point mutations on 5β-reductase (AKR1D1) enzyme function. Chemico-Biological Interactions. 191: 250-4. PMID 21185810 DOI: 10.1016/j.cbi.2010.12.020  1
2011 Byrns MC, Jin Y, Penning TM. Inhibitors of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3): overview and structural insights. The Journal of Steroid Biochemistry and Molecular Biology. 125: 95-104. PMID 21087665 DOI: 10.1016/j.jsbmb.2010.11.004  1
2011 Gelhaus SL, Harvey RG, Penning TM, Blair IA. Regulation of benzo[a]pyrene-mediated DNA- and glutathione-adduct formation by 2,3,7,8-tetrachlorodibenzo-p-dioxin in human lung cells. Chemical Research in Toxicology. 24: 89-98. PMID 21028851 DOI: 10.1021/tx100297z  1
2011 Penning TM. Metabolic activation of chemical carcinogens Current Cancer Research. 6: 135-158. DOI: 10.1007/978-1-61737-995-6_7  1
2011 Penning TM. Preface Current Cancer Research. 6.  1
2010 Wu A, Duan Y, Xu D, Penning TM, Harvey RG. Regiospecific oxidation of polycyclic aromatic phenols to quinones by hypervalent iodine reagents. Tetrahedron. 66: 2111-2118. PMID 24014894 DOI: 10.1016/j.tet.2009.12.022  1
2010 Dozmorov MG, Azzarello JT, Wren JD, Fung KM, Yang Q, Davis JS, Hurst RE, Culkin DJ, Penning TM, Lin HK. Elevated AKR1C3 expression promotes prostate cancer cell survival and prostate cell-mediated endothelial cell tube formation: implications for prostate cancer progression. Bmc Cancer. 10: 672. PMID 21134280 DOI: 10.1186/1471-2407-10-672  1
2010 Steckelbroeck S, Lütjohann D, Bauman DR, Ludwig M, Friedl A, Hans VH, Penning TM, Klingmüller D. Non-stereo-selective cytosolic human brain tissue 3-ketosteroid reductase is refractory to inhibition by AKR1C inhibitors. Biochimica Et Biophysica Acta. 1801: 1221-31. PMID 20673851 DOI: 10.1016/j.bbalip.2010.07.005  0.56
2010 Zakharov V, Lin HK, Azzarello J, McMeekin S, Moore KN, Penning TM, Fung KM. Suppressed expression of type 2 3alpha/type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) in endometrial hyperplasia and carcinoma. International Journal of Clinical and Experimental Pathology. 3: 608-17. PMID 20661409  1
2010 Drury JE, Mindnich R, Penning TM. Characterization of disease-related 5beta-reductase (AKR1D1) mutations reveals their potential to cause bile acid deficiency. The Journal of Biological Chemistry. 285: 24529-37. PMID 20522910 DOI: 10.1074/jbc.M110.127779  1
2010 Penning TM. New frontiers in androgen biosynthesis and metabolism. Current Opinion in Endocrinology, Diabetes, and Obesity. 17: 233-9. PMID 20186052 DOI: 10.1097/MED.0b013e3283381a31  1
2010 Knudsen KE, Penning TM. Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer. Trends in Endocrinology and Metabolism: Tem. 21: 315-24. PMID 20138542 DOI: 10.1016/j.tem.2010.01.002  1
2010 Penning TM, Lee SH, Jin Y, Gutierrez A, Blair IA. Liquid chromatography-mass spectrometry (LC-MS) of steroid hormone metabolites and its applications Journal of Steroid Biochemistry and Molecular Biology. 121: 546-555. PMID 20083198 DOI: 10.1016/j.jsbmb.2010.01.005  1
2010 Byrns MC, Duan L, Lee SH, Blair IA, Penning TM. Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer Journal of Steroid Biochemistry and Molecular Biology. 118: 177-187. PMID 20036328 DOI: 10.1016/j.jsbmb.2009.12.009  1
2010 Ashley RA, Yu Z, Fung KM, Frimberger D, Kropp BP, Penning TM, Lin HK. Developmental evaluation of aldo-keto reductase 1C3 expression in the cryptorchid testis. Urology. 76: 67-72. PMID 19942269 DOI: 10.1016/j.urology.2009.09.046  1
2010 Penning TM. Polycyclic Aromatic Hydrocarbons: Multiple Metabolic Pathways and the DNA Lesions Formed The Chemical Biology of Dna Damage. 131-155. DOI: 10.1002/9783527630110.ch6  1
2009 Szewczuk LM, Penning TM. Co-oxidation by cyclooxygenases. Current Protocols in Toxicology / Editorial Board, Mahin D. Maines (Editor-in-Chief) ... [Et Al.]. Unit4.30. PMID 23045015 DOI: 10.1002/0471140856.tx0430s42  1
2009 Azzarello JT, Lin HK, Gherezghiher A, Zakharov V, Yu Z, Kropp BP, Culkin DJ, Penning TM, Fung KM. Expression of AKR1C3 in renal cell carcinoma, papillary urothelial carcinoma, and Wilms' tumor. International Journal of Clinical and Experimental Pathology. 3: 147-55. PMID 20126582  1
2009 Park JH, Mangal D, Frey AJ, Harvey RG, Blair IA, Penning TM. Aryl hydrocarbon receptor facilitates DNA strand breaks and 8-oxo-2'-deoxyguanosine formation by the aldo-keto reductase product benzo[a]pyrene-7,8-dione. The Journal of Biological Chemistry. 284: 29725-34. PMID 19726680 DOI: 10.1074/jbc.M109.042143  1
2009 Mindnich RD, Penning TM. Aldo-keto reductase (AKR) superfamily: genomics and annotation. Human Genomics. 3: 362-70. PMID 19706366  1
2009 MacLeod AK, McMahon M, Plummer SM, Higgins LG, Penning TM, Igarashi K, Hayes JD. Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds. Carcinogenesis. 30: 1571-80. PMID 19608619 DOI: 10.1093/carcin/bgp176  1
2009 Drury JE, Di Costanzo L, Penning TM, Christianson DW. Inhibition of human steroid 5beta-reductase (AKR1D1) by finasteride and structure of the enzyme-inhibitor complex. The Journal of Biological Chemistry. 284: 19786-90. PMID 19515843 DOI: 10.1074/jbc.C109.016931  1
2009 Dozmorov MG, Hurst RE, Culkin DJ, Kropp BP, Frank MB, Osban J, Penning TM, Lin HK. Unique patterns of molecular profiling between human prostate cancer LNCaP and PC-3 cells. The Prostate. 69: 1077-90. PMID 19343732 DOI: 10.1002/pros.20960  1
2009 Mangal D, Vudathala D, Park JH, Seon HL, Penning TM, Blair IA. Analysis of 7,8-dihydro-8-oxo-2′-deoxyguanosine in cellular DNA during oxidative stress Chemical Research in Toxicology. 22: 788-797. PMID 19309085 DOI: 10.1021/tx800343c  1
2009 Penning TM, Byrns MC. Steroid hormone transforming aldo-keto reductases and cancer. Annals of the New York Academy of Sciences. 1155: 33-42. PMID 19250190 DOI: 10.1111/j.1749-6632.2009.03700.x  1
2009 Jin Y, Duan L, Lee SH, Kloosterboer HJ, Blair IA, Penning TM. Human cytosolic hydroxysteroid dehydrogenases of the aldo-ketoreductase superfamily catalyze reduction of conjugated steroids: Implications for phase I and phase II steroid hormone metabolism Journal of Biological Chemistry. 284: 10013-10022. PMID 19218247 DOI: 10.1074/jbc.M809465200  1
2009 Xu D, Penning TM, Blair IA, Harvey RG. Synthesis of phenol and quinone metabolites of benzo[a]pyrene, a carcinogenic component of tobacco smoke implicated in lung cancer. The Journal of Organic Chemistry. 74: 597-604. PMID 19132942 DOI: 10.1021/jo801864m  1
2009 Di Costanzo L, Penning TM, Christianson DW. Aldo-keto reductases in which the conserved catalytic histidine is substituted. Chemico-Biological Interactions. 178: 127-33. PMID 19028475 DOI: 10.1016/j.cbi.2008.10.046  1
2009 Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jörnvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, et al. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. Chemico-Biological Interactions. 178: 94-8. PMID 19027726 DOI: 10.1016/j.cbi.2008.10.040  1
2009 Byrns MC, Penning TM. Type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3): role in breast cancer and inhibition by non-steroidal anti-inflammatory drug analogs. Chemico-Biological Interactions. 178: 221-7. PMID 19010312 DOI: 10.1016/j.cbi.2008.10.024  1
2009 Di Costanzo L, Drury JE, Christianson DW, Penning TM. Structure and catalytic mechanism of human steroid 5beta-reductase (AKR1D1). Molecular and Cellular Endocrinology. 301: 191-8. PMID 18848863 DOI: 10.1016/j.mce.2008.09.013  1
2008 Ran C, Xu D, Dai Q, Penning TM, Blair IA, Harvey RG. Synthesis of (13)C2-Benzo[a]pyrene and its 7,8-Dihydrodiol and 7,8-Dione Implicated as Carcinogenic Metabolites. Tetrahedron Letters. 49: 4531-4533. PMID 24155502 DOI: 10.1016/j.tetlet.2008.05.033  1
2008 Penning TM, Lerman C. Genomics of smoking exposure and cessation: lessons for cancer prevention and treatment. Cancer Prevention Research (Philadelphia, Pa.). 1: 80-3. PMID 19138939 DOI: 10.1158/1940-6207.CAPR-08-0047  1
2008 Quinn AM, Harvey RG, Penning TM. Oxidation of PAH trans-dihydrodiols by human aldo-keto reductase AKR1B10. Chemical Research in Toxicology. 21: 2207-15. PMID 18788756 DOI: 10.1021/tx8002005  1
2008 Park JH, Gelhaus S, Vedantam S, Oliva AL, Batra A, Blair IA, Troxel AB, Field J, Penning TM. The pattern of p53 mutations caused by PAH o-quinones is driven by 8-oxo-dGuo formation while the spectrum of mutations is determined by biological selection for dominance. Chemical Research in Toxicology. 21: 1039-49. PMID 18489080 DOI: 10.1021/tx700404a  1
2008 Park JH, Mangal D, Tacka KA, Quinn AM, Harvey RG, Blair IA, Penning TM. Evidence for the aldo-keto reductase pathway of polycyclic aromatic trans-dihydrodiol activation in human lung A549 cells. Proceedings of the National Academy of Sciences of the United States of America. 105: 6846-51. PMID 18474869 DOI: 10.1073/pnas.0802776105  1
2008 Di Costanzo L, Drury JE, Penning TM, Christianson DW. Crystal structure of human liver Delta4-3-ketosteroid 5beta-reductase (AKR1D1) and implications for substrate binding and catalysis. The Journal of Biological Chemistry. 283: 16830-9. PMID 18407998 DOI: 10.1074/jbc.M801778200  1
2008 Quinn AM, Penning TM. Comparisons of (+/-)-benzo[a]pyrene-trans-7,8-dihydrodiol activation by human cytochrome P450 and aldo-keto reductase enzymes: effect of redox state and expression levels. Chemical Research in Toxicology. 21: 1086-94. PMID 18402469 DOI: 10.1021/tx700345v  1
2008 Xu D, Duan Y, Blair IA, Penning TM, Harvey RG. Synthesis of dibenzo[def,p]chrysene, its active metabolites, and their 13C-labeled analogues. Organic Letters. 10: 1059-62. PMID 18284245 DOI: 10.1021/ol7029323  1
2008 Shultz CA, Palackal NT, Mangal D, Harvey RG, Blair IA, Penning TM. Fjord-region benzo[g]chrysene-11,12-dihydrodiol and benzo[c]phenanthrene-3,4-dihydrodiol as substrates for rat liver dihydrodiol dehydrogenase (AKR1C9): structural basis for stereochemical preference. Chemical Research in Toxicology. 21: 668-77. PMID 18251511 DOI: 10.1021/tx7003695  1
2008 Ran C, Dai Q, Ruan Q, Penning TM, Blair IA, Harvey RG. Strategies for synthesis of adducts of omicron-quinone metabolites of carcinogenic polycyclic aromatic hydrocarbons with 2'-deoxyribonucleosides. The Journal of Organic Chemistry. 73: 992-1003. PMID 18181642 DOI: 10.1021/jo701667u  1
2008 Penning TM, Jin Y, Rizner TL, Bauman DR. Pre-receptor regulation of the androgen receptor. Molecular and Cellular Endocrinology. 281: 1-8. PMID 18060684 DOI: 10.1016/j.mce.2007.10.008  1
2008 Byrns MC, Steckelbroeck S, Penning TM. An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3alpha-HSD, type 5 17beta-HSD, and prostaglandin F synthase), a potential target for the treatment of hormone dependent and hormone independent malignancies. Biochemical Pharmacology. 75: 484-93. PMID 17950253 DOI: 10.1016/j.bcp.2007.09.008  1
2008 Park JH, Penning TM. Thermal Treatment: Polyaromatic Hydrocarbons Process-Induced Food Toxicants: Occurrence, Formation, Mitigation, and Health Risks. 243-282. DOI: 10.1002/9780470430101.ch2h  1
2007 Cooper WC, Jin Y, Penning TM. Elucidation of a complete kinetic mechanism for a mammalian hydroxysteroid dehydrogenase (HSD) and identification of all enzyme forms on the reaction coordinate: the example of rat liver 3alpha-HSD (AKR1C9). The Journal of Biological Chemistry. 282: 33484-93. PMID 17848571 DOI: 10.1074/jbc.M703414200  1
2007 Jiang H, Gelhaus SL, Mangal D, Harvey RG, Blair IA, Penning TM. Metabolism of benzo[a]pyrene in human bronchoalveolar H358 cells using liquid chromatography-mass spectrometry. Chemical Research in Toxicology. 20: 1331-41. PMID 17702526 DOI: 10.1021/tx700107z  1
2007 Penning TM, Drury JE. Human aldo-keto reductases: Function, gene regulation, and single nucleotide polymorphisms. Archives of Biochemistry and Biophysics. 464: 241-50. PMID 17537398 DOI: 10.1016/j.abb.2007.04.024  1
2007 Ruan Q, Gelhaus SL, Penning TM, Harvey RG, Blair IA. Aldo-keto reductase- and cytochrome P450-dependent formation of benzo[a]pyrene-derived DNA adducts in human bronchoalveolar cells. Chemical Research in Toxicology. 20: 424-31. PMID 17295519 DOI: 10.1021/tx060180b  1
2007 Penning TM, Bauman DR, Jin Y, Rizner TL. Identification of the molecular switch that regulates access of 5alpha-DHT to the androgen receptor. Molecular and Cellular Endocrinology. 265: 77-82. PMID 17223255 DOI: 10.1016/j.mce.2006.12.007  1
2007 Jin Y, Penning TM. Aldo-keto reductases and bioactivation/detoxication. Annual Review of Pharmacology and Toxicology. 47: 263-92. PMID 16970545 DOI: 10.1146/annurev.pharmtox.47.120505.105337  1
2006 Shen YM, Troxel AB, Vedantam S, Penning TM, Field J. Comparison of p53 mutations induced by PAH o-quinones with those caused by anti-benzo[a]pyrene diol epoxide in vitro: role of reactive oxygen and biological selection. Chemical Research in Toxicology. 19: 1441-50. PMID 17112231 DOI: 10.1021/tx0601206  1
2006 Jin Y, Penning TM. Multiple steps determine the overall rate of the reduction of 5alpha-dihydrotestosterone catalyzed by human type 3 3alpha-hydroxysteroid dehydrogenase: implications for the elimination of androgens. Biochemistry. 45: 13054-63. PMID 17059222 DOI: 10.1021/bi060591r  1
2006 Bauman DR, Steckelbroeck S, Peehl DM, Penning TM. Transcript profiling of the androgen signal in normal prostate, benign prostatic hyperplasia, and prostate cancer. Endocrinology. 147: 5806-16. PMID 16959841 DOI: 10.1210/en.2006-0627  1
2006 Yee DJ, Balsanek V, Bauman DR, Penning TM, Sames D. Fluorogenic metabolic probes for direct activity readout of redox enzymes: Selective measurement of human AKR1C2 in living cells. Proceedings of the National Academy of Sciences of the United States of America. 103: 13304-9. PMID 16938874 DOI: 10.1073/pnas.0604672103  1
2006 Park JH, Troxel AB, Harvey RG, Penning TM. Polycyclic aromatic hydrocarbon (PAH) o-quinones produced by the aldo-keto-reductases (AKRs) generate abasic sites, oxidized pyrimidines, and 8-oxo-dGuo via reactive oxygen species. Chemical Research in Toxicology. 19: 719-28. PMID 16696575 DOI: 10.1021/tx0600245  1
2006 Ruan Q, Kim HY, Jiang H, Penning TM, Harvey RG, Blair IA. Quantification of benzo[a]pyrene diol epoxide DNA-adducts by stable isotope dilution liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry : Rcm. 20: 1369-80. PMID 16557497 DOI: 10.1002/rcm.2457  1
2006 Jin Y, Penning TM. Molecular docking simulations of steroid substrates into human cytosolic hydroxysteroid dehydrogenases (AKR1C1 and AKR1C2): insights into positional and stereochemical preferences. Steroids. 71: 380-91. PMID 16455123 DOI: 10.1016/j.steroids.2005.12.002  1
2006 Penning TM, Steckelbroeck S, Bauman DR, Miller MW, Jin Y, Peehl DM, Fung KM, Lin HK. Aldo-keto reductase (AKR) 1C3: role in prostate disease and the development of specific inhibitors. Molecular and Cellular Endocrinology. 248: 182-91. PMID 16417966 DOI: 10.1016/j.mce.2005.12.009  1
2006 Jiang H, Vudathala DK, Blair IA, Penning TM. Competing roles of aldo-keto reductase 1A1 and cytochrome P4501B1 in benzo[a]pyrene-7,8-diol activation in human bronchoalveolar H358 cells: role of AKRs in P4501B1 induction. Chemical Research in Toxicology. 19: 68-78. PMID 16411658 DOI: 10.1021/tx0502488  1
2006 Steckelbroeck S, Oyesanmi B, Jin Y, Lee SH, Kloosterboer HJ, Penning TM. Tibolone metabolism in human liver is catalyzed by 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four isoforms of the aldo-keto reductase (AKR)1C subfamily. The Journal of Pharmacology and Experimental Therapeutics. 316: 1300-9. PMID 16339391 DOI: 10.1124/jpet.105.091587  0.48
2006 Bauman DR, Steckelbroeck S, Williams MV, Peehl DM, Penning TM. Identification of the major oxidative 3alpha-hydroxysteroid dehydrogenase in human prostate that converts 5alpha-androstane-3alpha,17beta-diol to 5alpha-dihydrotestosterone: a potential therapeutic target for androgen-dependent disease. Molecular Endocrinology (Baltimore, Md.). 20: 444-58. PMID 16179381 DOI: 10.1210/me.2005-0287  0.56
2005 Gao J, Voss AA, Pessah IN, Lauer FT, Penning TM, Burchiel SW. Ryanodine receptor-mediated rapid increase in intracellular calcium induced by 7,8-benzo(a)pyrene quinone in human and murine leukocytes. Toxicological Sciences : An Official Journal of the Society of Toxicology. 87: 419-26. PMID 16049270 DOI: 10.1093/toxsci/kfi265  1
2005 Park JH, Gopishetty S, Szewczuk LM, Troxel AB, Harvey RG, Penning TM. Formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dGuo) by PAH o-quinones: involvement of reactive oxygen species and copper(II)/copper(I) redox cycling. Chemical Research in Toxicology. 18: 1026-37. PMID 15962938 DOI: 10.1021/tx050001a  1
2005 Penning TM. AKR1B10: A new diagnostic marker of non-small cell lung carcinoma in smokers Clinical Cancer Research. 11: 1687-1690. PMID 15755988 DOI: 10.1158/1078-0432.CCR-05-0071  1
2005 Jiang H, Shen YM, Quinn AM, Penning TM. Competing roles of cytochrome P450 1A1/1B1 and aldo-keto reductase 1A1 in the metabolic activation of (+/-)-7,8-dihydroxy-7,8-dihydro-benzo[a]pyrene in human bronchoalveolar cell extracts. Chemical Research in Toxicology. 18: 365-74. PMID 15720144 DOI: 10.1021/tx0497245  1
2005 Szewczuk LM, Lee SH, Blair IA, Penning TM. Viniferin formation by COX-1: evidence for radical intermediates during co-oxidation of resveratrol. Journal of Natural Products. 68: 36-42. PMID 15679314 DOI: 10.1021/np049702i  1
2005 Bauman DR, Rudnick SI, Szewczuk LM, Jin Y, Gopishetty S, Penning TM. Development of nonsteroidal anti-inflammatory drug analogs and steroid carboxylates selective for human aldo-keto reductase isoforms: potential antineoplastic agents that work independently of cyclooxygenase isozymes. Molecular Pharmacology. 67: 60-8. PMID 15475569 DOI: 10.1124/mol.104.006569  1
2004 Bauman DR, Steckelbroeck S, Penning TM. The roles of aldo-keto reductases in steroid hormone action. Drug News & Perspectives. 17: 563-78. PMID 15645014 DOI: 10.1358/dnp.2004.17.9.872570  1
2004 Szewczuk LM, Penning TM. Mechanism-based inactivation of COX-1 by red wine m-hydroquinones: a structure-activity relationship study. Journal of Natural Products. 67: 1777-82. PMID 15568761 DOI: 10.1021/np0498410  1
2004 Steckelbroeck S, Jin Y, Oyesanmi B, Kloosterboer HJ, Penning TM. Tibolone is metabolized by the 3α/3β-hydroxysteroid dehydrogenase activities of the four human isozymes of the aldo-keto reductase 1C subfamily: Inversion of stereospecificity with a Δ5(10)-3- ketosteroid Molecular Pharmacology. 66: 1702-1711. PMID 15383625 DOI: 10.1124/mol.104.004515  1
2004 Heredia VV, Penning TM. Dissection of the physiological interconversion of 5alpha-DHT and 3alpha-diol by rat 3alpha-HSD via transient kinetics shows that the chemical step is rate-determining: effect of mutating cofactor and substrate-binding pocket residues on catalysis. Biochemistry. 43: 12028-37. PMID 15379543 DOI: 10.1021/bi0489762  1
2004 Patte-Mensah C, Penning TM, Mensah-Nyagan AG. Anatomical and cellular localization of neuroactive 5α/3α- reduced steroid-synthesizing enzymes in the spinal cord Journal of Comparative Neurology. 477: 286-299. PMID 15305365 DOI: 10.1002/cne.20251  1
2004 Heredia VV, Cooper WC, Kruger RG, Jin Y, Penning TM. Alanine scanning mutagenesis of the testosterone binding site of rat 3 alpha-hydroxysteroid dehydrogenase demonstrates contact residues influence the rate-determining step. Biochemistry. 43: 5832-41. PMID 15134457 DOI: 10.1021/bi0499563  1
2004 Harvey RG, Dai Q, Ran C, Penning TM. Synthesis of the o-quinones and other oxidized metabolites of polycyclic aromatic hydrocarbons implicated in carcinogenesis. The Journal of Organic Chemistry. 69: 2024-32. PMID 15058949 DOI: 10.1021/jo030348n  1
2004 Penning TM. Aldo-Keto Reductases and Formation of Polycyclic Aromatic Hydrocarbon o-Quinones Methods in Enzymology. 378: 31-67. PMID 15038957 DOI: 10.1016/S0076-6879(04)78003-9  1
2004 Penning TM, Jin Y, Steckelbroeck S, Rižner TL, Lewis M. Structure-function of human 3α-hydroxysteroid dehydrogenases: Genes and proteins Molecular and Cellular Endocrinology. 215: 63-72. PMID 15026176 DOI: 10.1016/j.mce.2003.11.006  1
2004 Szewczuk LM, Forti L, Stivala LA, Penning TM. Resveratrol is a peroxidase-mediated inactivator of COX-1 but not COX-2: a mechanistic approach to the design of COX-1 selective agents. The Journal of Biological Chemistry. 279: 22727-37. PMID 15020596 DOI: 10.1074/jbc.M314302200  1
2004 Steckelbroeck S, Jin Y, Gopishetty S, Oyesanmi B, Penning TM. Human cytosolic 3α-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3β-hydroxysteroid dehydrogenase activity: Implications for steroid hormone metabolism and action Journal of Biological Chemistry. 279: 10784-10795. PMID 14672942 DOI: 10.1074/jbc.M313308200  1
2004 Penning TM, Shen YM, Mick R, Shults J, Field JM. Polycyclic aromatic hydrocarbon o-quinones mutate p53 in human lung adenocarcinoma (A549) cells Polycyclic Aromatic Compounds. 24: 583-596. DOI: 10.1080/10406630490471717  1
2003 Penning TM, Jin Y, Heredia VV, Lewis M. Structure-function relationships in 3alpha-hydroxysteroid dehydrogenases: a comparison of the rat and human isoforms. The Journal of Steroid Biochemistry and Molecular Biology. 85: 247-55. PMID 12943710 DOI: 10.1016/S0960-0760(03)00236-X  1
2003 Penning TM. Hydroxysteroid dehydrogenases and pre-receptor regulation of steroid hormone action Human Reproduction Update. 9: 193-205. PMID 12861966 DOI: 10.1093/humupd/dmg022  1
2003 Hyndman D, Bauman DR, Heredia VV, Penning TM. The aldo-keto reductase superfamily homepage. Chemico-Biological Interactions. 143: 621-31. PMID 12604248 DOI: 10.1016/S0009-2797(02)00193-X  1
2003 Rižner TL, Lin HK, Penning TM. Role of human type 3 3α-hydroxysteroid dehydrogenase (AKR1C2) in androgen metabolism of prostate cancer cells Chemico-Biological Interactions. 143: 401-409. PMID 12604227 DOI: 10.1016/S0009-2797(02)00179-5  1
2003 Heredia VV, Kruger RG, Penning TM. Steroid-binding site residues dictate optimal substrate positioning in rat 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD or AKR1C9). Chemico-Biological Interactions. 143: 393-400. PMID 12604226 DOI: 10.1016/S0009-2797(02)00176-X  1
2003 Jin Y, Cooper WC, Penning TM. Examination of the differences in structure-function of human and rat 3α-hydroxysteroid dehydrogenase Chemico-Biological Interactions. 143: 383-392. PMID 12604225 DOI: 10.1016/S0009-2797(02)00207-7  1
2003 Penning TM. Introduction and overview of the aldo-keto reductase superfamily Acs Symposium Series. 865: 3-20.  1
2003 Harvey RG, Dai Q, Ran C, Penning TM. Efficient syntheses of the active metabolites of carcinogenic polycyclic aromatic hydrocarbons Acs Symposium Series. 865: 115-126.  1
2002 Yu D, Kazanietz MG, Harvey RG, Penning TM. Polycyclic aromatic hydrocarbon o-quinones inhibit the activity of the catalytic fragment of protein kinase C. Biochemistry. 41: 11888-94. PMID 12269833 DOI: 10.1021/bi020270p  1
2002 Yu D, Berlin JA, Penning TM, Field J. Reactive oxygen species generated by PAH o-quinones cause change-in-function mutations in p53 Chemical Research in Toxicology. 15: 832-842. PMID 12067251 DOI: 10.1021/tx010177m  1
2002 Palackal NT, Lee SH, Harvey RG, Blair IA, Penning TM. Activation of polycyclic aromatic hydrocarbon trans-dihydrodiol proximate carcinogens by human aldo-keto reductase (AKR1C) enzymes and their functional overexpression in human lung carcinoma (A549) cells. The Journal of Biological Chemistry. 277: 24799-808. PMID 11978787 DOI: 10.1074/jbc.M112424200  1
2002 Penning TM, Palackal NT, Blair IA, Harvey RG. The aldo-keto reductases and polycyclic aromatic hydrocarbon activation Polycyclic Aromatic Compounds. 22: 791-800. DOI: 10.1080/10406630213611  1
2002 Yu D, Penning TM, Field JM, Berlin JA. Benzo[a]pyrene-7,8-dione is more mutagenic than anti-BPDE on p53 and is dependent on the generation of reactive oxygen species Polycyclic Aromatic Compounds. 22: 881-891. DOI: 10.1080/10406630213593  1
2002 Palackal NT, Lee SH, Harvey RG, Blair IA, Penning TM. Human AKR1C isoforms oxidize the potent proximate carcinogen 7,12-DMBA-3,4-diol in the human lung A549 carcinoma cell line Polycyclic Aromatic Compounds. 22: 801-810. DOI: 10.1080/10406630213576  1
2001 Penning TM, Jez JM. Enzyme redesign. Chemical Reviews. 101: 3027-46. PMID 11710061 DOI: 10.1021/cr000049n  1
2001 Palackal NT, Burczynski ME, Harvey RG, Penning TM. The ubiquitous aldehyde reductase (AKR1A1) oxidizes proximate carcinogen trans-dihydrodiols to o-quinones: potential role in polycyclic aromatic hydrocarbon activation. Biochemistry. 40: 10901-10. PMID 11535067 DOI: 10.1021/bi010872t  1
2001 Jin Y, Stayrook SE, Albert RH, Palackal NT, Penning TM, Lewis M. Crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase/bile acid binding protein complexed with NADP(+) and ursodeoxycholate. Biochemistry. 40: 10161-8. PMID 11513593 DOI: 10.1021/bi010919a  1
2001 Jin Y, Penning TM. Steroid 5α-reductases and 3α-hydroxysteroid dehydrogenases: Key enzymes in androgen metabolism Best Practice and Research: Clinical Endocrinology and Metabolism. 15: 79-94. PMID 11469812 DOI: 10.1053/beem.2001.0120  1
2001 Tsuruda L, Hou Yt, Penning TM. Stable expression of rat dihydrodiol dehydrogenase (AKR1C9) in human breast MCF-7 cells results in the formation of PAH-o-quinones and enzyme mediated cell death. Chemical Research in Toxicology. 14: 856-62. PMID 11453732 DOI: 10.1021/tx0100035  1
2001 Palackal NT, Burczynski ME, Harvey RG, Penning TM. Metabolic activation of polycyclic aromatic hydrocarbon trans-dihydrodiols by ubiquitously expressed aldehyde reductase (AKR1A1). Chemico-Biological Interactions. 130: 815-24. PMID 11306097 DOI: 10.1016/S0009-2797(00)00237-4  1
2001 Penning TM, Ma H, Jez JM. Engineering steroid hormone specificity into aldo-keto reductases. Chemico-Biological Interactions. 130: 659-71. PMID 11306084 DOI: 10.1016/S0009-2797(00)00257-X  1
2001 Jez JM, Penning TM. The aldo-keto reductase (AKR) superfamily: an update. Chemico-Biological Interactions. 130: 499-525. PMID 11306071 DOI: 10.1016/S0009-2797(00)00295-7  1
2001 Penning TM, Burczynski ME, Jez JM, Lin HK, Ma H, Moore M, Ratnam K, Palackal N. Structure-function aspects and inhibitor design of type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3). Molecular and Cellular Endocrinology. 171: 137-49. PMID 11165022 DOI: 10.1016/S0303-7207(00)00426-3  1
2001 Burczynski ME, Sridhar GR, Palackal NT, Penning TM. The reactive oxygen species--and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the alpha,beta-unsaturated aldehyde 4-hydroxy-2-nonenal to 1,4-dihydroxy-2-nonene. The Journal of Biological Chemistry. 276: 2890-7. PMID 11060293 DOI: 10.1074/jbc.M006655200  1
2000 Penning TM, Burczynski ME, Jez JM, Hung CF, Lin HK, Ma H, Moore M, Palackal N, Ratnam K. Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones. The Biochemical Journal. 351: 67-77. PMID 10998348 DOI: 10.1042/0264-6021:3510067  1
2000 Bolton JL, Trush MA, Penning TM, Dryhurst G, Monks TJ. Role of quinones in toxicology Chemical Research in Toxicology. 13: 135-160. PMID 10725110 DOI: 10.1021/tx9902082  1
2000 Burczynski ME, Penning TM. Genotoxic polycyclic aromatic hydrocarbon ortho-quinones generated by aldo-keto reductases induce CYP1A1 via nuclear translocation of the aryl hydrocarbon receptor Cancer Research. 60: 908-915. PMID 10706104  1
2000 Ma H, Ratnam K, Penning TM. Mutation of nicotinamide pocket residues in rat liver 3 alpha-hydroxysteroid dehydrogenase reveals different modes of cofactor binding. Biochemistry. 39: 102-9. PMID 10625484 DOI: 10.1021/bi991659o  1
1999 Lin HK, Hung CF, Moore M, Penning TM. Genomic structure of rat 3α-hydroxysteroid/dihydrodiol dehydrogenase (3α-HSD/DD, AKR1C9) Journal of Steroid Biochemistry and Molecular Biology. 71: 29-39. PMID 10619355 DOI: 10.1016/S0960-0760(99)00122-3  1
1999 Hung CF, Penning TM. Members of the nuclear factor 1 transcription factor family regulate rat 3α-hydroxysteroid/dihydrodiol dehydrogenase (3α-HSD/DD AKR1C9) gene expression: A member of the aldo-keto reductase superfamily Molecular Endocrinology. 13: 1704-1717. PMID 10517672  1
1999 Ma H, Penning TM. Conversion of mammalian 3α-hydroxysteroid dehydrogenase to 20α-hydroxysteroid dehydrogenase using loop chimeras: Changing specificity from androgens to progestins Proceedings of the National Academy of Sciences of the United States of America. 96: 11161-11166. PMID 10500147  1
1999 Penning TM. Molecular determinants of steroid recognition and catalysis in aldo- keto reductases. Lessons from 3α-hydroxysteroid dehydrogenase Journal of Steroid Biochemistry and Molecular Biology. 69: 211-225. PMID 10418995 DOI: 10.1016/S0960-0760(99)00038-2  1
1999 Ma H, Penning TM. Characterization of homogeneous recombinant rat ovarian 20α-hydroxysteroid dehydrogenase: Fluorescent properties and inhibition profile Biochemical Journal. 341: 853-859. PMID 10417353 DOI: 10.1042/0264-6021:3410853  1
1999 Ratnam K, Ma H, Penning TM. The arginine 276 anchor for NADP(H) dictates fluorescence kinetic transients in 3α-hydroxysteroid dehydrogenase, a representative aldo-keto reductase Biochemistry. 38: 7856-7864. PMID 10387026 DOI: 10.1021/bi982838t  1
1999 McCoull KD, Rindgen D, Blair IA, Penning TM. Synthesis and characterization of polycyclic aromatic hydrocarbon o- quinone depurinating N7-guanine adducts Chemical Research in Toxicology. 12: 237-246. PMID 10077486 DOI: 10.1021/tx980182z  1
1999 Burczynski ME, Lin HK, Penning TM. Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: Implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase Cancer Research. 59: 607-614. PMID 9973208  1
1999 Penning TM, Burczynski ME, Hung CF, McCoull KD, Palackal NT, Tsuruda LS. Dihydrodiol dehydrogenases and polycyclic aromatic hydrocarbon activation: generation of reactive and redox active o-quinones. Chemical Research in Toxicology. 12: 1-18. PMID 9894013 DOI: 10.1021/tx980143n  1
1999 Burczynski ME, Palackal NT, Harvey RG, Penning TM. Polycyclic aromatic hydrocarbon trans-dihydrodiol specificity of four recombinant human dihydrodiol dehydrogenase isoforms Polycyclic Aromatic Compounds. 16: 205-214.  1
1999 Harvey RG, Penning TM, Jarabak J, Zhang FJ. Role of quinone metabolites in PAH carcinogenesis Polycyclic Aromatic Compounds. 16: 13-20.  1
1998 Schlegel BP, Ratnam K, Penning TM. Retention of NADPH-linked quinone reductase activity in an Aldo-Keto reductase following mutation of the catalytic tyrosine Biochemistry. 37: 11003-11011. PMID 9692994 DOI: 10.1021/bi980475r  1
1998 Jez JM, Penning TM. Engineering steroid 5 beta-reductase activity into rat liver 3 alpha-hydroxysteroid dehydrogenase. Biochemistry. 37: 9695-703. PMID 9657682 DOI: 10.1021/bi980294p  1
1998 Burczynski ME, Harvey RG, Penning TM. Expression and characterization of four recombinant human dihydrodiol dehydrogenase isoforms: oxidation of trans-7, 8-dihydroxy-7,8-dihydrobenzo[a]pyrene to the activated o-quinone metabolite benzo[a]pyrene-7,8-dione. Biochemistry. 37: 6781-90. PMID 9578563 DOI: 10.1021/bi972725u  1
1998 Schlegel BP, Jez JM, Penning TM. Mutagenesis of 3 alpha-hydroxysteroid dehydrogenase reveals a "push-pull" mechanism for proton transfer in aldo-keto reductases. Biochemistry. 37: 3538-48. PMID 9521675 DOI: 10.1021/bi9723055  1
1998 Hou YT, Lin HK, Penning TM. Dexamethasone regulation of the rat 3alpha-hydroxysteroid/dihydrodiol dehydrogenase gene. Molecular Pharmacology. 53: 459-66. PMID 9495812  1
1997 Tang MS, Askonas LJ, Penning TM. Bromoacetamido-analogs of indomethacin and mefenamic acid affinity- label prostaglandin H2 synthase at two sites Advances in Experimental Medicine and Biology. 400: 77-84. PMID 9547540  1
1997 Lin HK, Jez JM, Schlegel BP, Peehl DM, Pachter JA, Penning TM. Expression and characterization of recombinant type 2 3α- hydroxysteroid dehydrogenase (HSD) from human prostate: Demonstration of bifunctional 3α/17β-HSD activity and cellular distribution Molecular Endocrinology. 11: 1971-1984. PMID 9415401  1
1997 Jez JM, Flynn TG, Penning TM. A new nomenclature for the aldo-keto reductase superfamily. Biochemical Pharmacology. 54: 639-47. PMID 9310340 DOI: 10.1016/S0006-2952(97)84253-0  1
1997 Jez JM, Bennett MJ, Schlegel BP, Lewis M, Penning TM. Comparative anatomy of the aldo-keto reductase superfamily. The Biochemical Journal. 326: 625-36. PMID 9307009  1
1997 Bennett MJ, Albert RH, Jez JM, Ma H, Penning TM, Lewis M. Steroid recognition and regulation of hormone action: crystal structure of testosterone and NADP+ bound to 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase. Structure (London, England : 1993). 5: 799-812. PMID 9261071  1
1997 Flowers L, Ohnishi T, Penning TM. DNA strand scission by polycyclic aromatic hydrocarbon o-quinones: Role of reactive oxygen species, Cu(II)/Cu(I) redox cycling, and o-Semiquinone Anion radicals Biochemistry. 36: 8640-8648. PMID 9214311 DOI: 10.1021/bi970367p  1
1997 Tang MS, Copeland RA, Penning TM. Detection of an Fe2+-protoporphyrin-IX intermediate during aspirin-treated prostaglandin H2 synthase II catalysis of arachidonic acid to 15-HETE Biochemistry. 36: 7527-7534. PMID 9200703 DOI: 10.1021/bi962750k  1
1997 Penning TM. Molecular endocrinology of hydroxysteroid dehydrogenases Endocrine Reviews. 18: 281-305. PMID 9183566 DOI: 10.1210/er.18.3.281  1
1997 Penning TM, Pawlowski JE, Schlegel BP, Jez JM, Lin HK, Hoog SS, Bennett MJ, Lewis M. "Mammalian 3 alpha-hydroxysteroid dehydrogenases". Steroids. 62: 455-6. PMID 9178434  1
1997 Jez JM, Flynn TG, Penning TM. A nomenclature system for the aldo-keto reductase superfamily. Advances in Experimental Medicine and Biology. 414: 579-600. PMID 9059665  1
1997 Penning TM. Hydroxysteroid dehydrogenases: New drug targets of the aldo-keto reductase superfamily Advances in Experimental Medicine and Biology. 414: 475-490. PMID 9059653  1
1997 Penning TM, Bennett MJ, Smith-Hoog S, Schlegel BP, Jez JM, Lewis M. Structure and function of 3 alpha-hydroxysteroid dehydrogenase. Steroids. 62: 101-11. PMID 9029723 DOI: 10.1016/S0039-128X(96)00167-5  1
1997 Penning TM, Lin HK, Jez JM, Ricigliano JW. Inhibition of type 3 3α-hydroxysteroid dehydrogenase (3α-HSD) Expert Opinion On Therapeutic Targets. 1: 141-145. DOI: 10.1517/14728222.1.1.141  1
1996 Penning TM. 3α-Hydroxysteroid dehydrogenase: Three dimensional structure and gene regulation Journal of Endocrinology. 150. PMID 8943801  1
1996 Jez JM, Schlegel BP, Penning TM. Characterization of the substrate binding site in rat liver 3alpha-hydroxysteroid/dihydrodiol dehydrogenase. The roles of tryptophans in ligand binding and protein fluorescence. The Journal of Biological Chemistry. 271: 30190-8. PMID 8939970 DOI: 10.1074/jbc.271.47.30190  1
1996 Penning TM, Ohnishi ST, Ohnishi T, Harvey RG. Generation of reactive oxygen species during the enzymatic oxidation of polycyclic aromatic hydrocarbon trans-dihydrodiols catalyzed by dihydrodiol dehydrogenase. Chemical Research in Toxicology. 9: 84-92. PMID 8924621 DOI: 10.1021/tx950055s  1
1996 Penning TM, Pawlowski JE, Schlegel BP, Jez JM, Lin HK, Hoog SS, Bennett MJ, Lewis M. Mammalian 3 alpha-hydroxysteroid dehydrogenases. Steroids. 61: 508-23. PMID 8883217 DOI: 10.1016/S0039-128X(96)00093-1  1
1996 Bennett MJ, Schlegel BP, Jez JM, Penning TM, Lewis M. Structure of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase complexed with NADP+. Biochemistry. 35: 10702-11. PMID 8718859 DOI: 10.1021/bi9604688  1
1996 Flowers-Geary L, Bleczinki W, Harvey RG, Penning TM. Cytotoxicity and mutagenicity of polycyclic aromatic hydrocarbon ortho-quinones produced by dihydrodiol dehydrogenase. Chemico-Biological Interactions. 99: 55-72. PMID 8620579 DOI: 10.1016/0009-2797(95)03660-1  1
1996 Penning TM. 17β-Hydroxysteroid dehydrogenase: Inhibitors and inhibitor design Endocrine-Related Cancer. 3: 41-56.  1
1995 Lin HK, Penning TM. Cloning, Sequencing, and Functional Analysis of the 5′-Flanking Region of the Rat 3α-Hydroxysteroid/Dihydrodiol Dehydrogenase Gene Cancer Research. 55: 4105-4113. PMID 7664287  1
1995 Flowers-Geary L, Harvey RG, Penning TM. Identification of benzo[a]pyrene-7,8-dione as an authentic metabolite of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene in isolated rat hepatocytes. Carcinogenesis. 16: 2707-15. PMID 7586190 DOI: 10.1093/carcin/16.11.2707  1
1994 Hou YT, Xia W, Pawlowski JE, Penning TM. Rat dihydrodiol dehydrogenase: complexity of gene structure and tissue-specific and sexually dimorphic gene expression. Cancer Research. 54: 247-55. PMID 8261447  1
1994 Pawlowski JE, Penning TM. Overexpression and mutagenesis of the cDNA for rat liver 3α- hydroxysteroid/dihydrodiol dehydrogenase. Role of cysteines and tyrosines in catalysis Journal of Biological Chemistry. 269: 13502-13510. PMID 8175784  1
1994 Hoog SS, Pawlowski JE, Alzari PM, Penning TM, Lewis M. Three-dimensional structure of rat liver 3α-hydroxysteroid/ dihydrodiol dehydrogenase: A member of the aldo-keto reductase superfamily Proceedings of the National Academy of Sciences of the United States of America. 91: 2517-2521. PMID 8146147  1
1994 Schlegel BP, Pawlowski JE, Hu Y, Scolnick DM, Covey DF, Penning TM. Secosteroid mechanism-based inactivators and site-directed mutagenesis as probes for steroid hormone recognition by 3 alpha-hydroxysteroid dehydrogenase. Biochemistry. 33: 10367-74. PMID 8068673  1
1993 Shou M, Harvey RG, Penning TM. Reactivity of benzo[a]pyrene-7,8-dione with DNA. Evidence for the formation of deoxyguanosine adducts. Carcinogenesis. 14: 475-82. PMID 8384091 DOI: 10.1093/carcin/14.3.475  1
1993 Penning TM. Dihydrodiol dehydrogenase and its role in polycyclic aromatic hydrocarbon metabolism Chemico-Biological Interactions. 89: 1-34. PMID 8221964 DOI: 10.1016/0009-2797(93)03203-7  1
1993 Flowers-Geary L, Harvey RG, Penning TM. Cytotoxicity of polycyclic aromatic hydrocarbon o-quinones in rat and human hepatoma cells. Chemical Research in Toxicology. 6: 252-60. PMID 7686407  1
1992 Penning TM, Isaacson K, Richard Lyttle C. Hormonal regulation of 3α-hydroxysteroid/dihydrodiol dehydrogenase in rat liver cytosol Biochemical Pharmacology. 43: 1148-1151. PMID 1554387 DOI: 10.1016/0006-2952(92)90625-S  1
1992 Murty VS, Penning TM. Characterization of mercapturic acid and glutathionyl conjugates of benzo[a]pyrene-7,8-dione by two-dimensional NMR Bioconjugate Chemistry. 3: 218-224. PMID 1520725  1
1992 Shou M, Harvey RG, Penning TM. Contribution of dihydrodiol dehydrogenase to the metabolism of (±)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene in fortified rat liver subcellular fractions Carcinogenesis. 13: 1575-1582. PMID 1394842 DOI: 10.1093/carcin/13.9.1575  1
1992 Murty VS, Penning TM. Polycyclic aromatic hydrocarbon (PAH) ortho-quinone conjugate chemistry: Kinetics of thiol addition to PAH ortho-quinones and structures of thioether adducts of naphthalene-1,2-dione Chemico-Biological Interactions. 84: 169-188. PMID 1394622 DOI: 10.1016/0009-2797(92)90077-X  1
1992 Flowers-Geary L, Harvey RG, Penning TM. Examination of diols and diol epoxides of polycyclic aromatic hydrocarbons as substrates for rat liver dihydrodiol dehydrogenase Chemical Research in Toxicolgy. 5: 576-583. PMID 1391625  1
1991 Penning TM, Abrams WR, Pawlowski JE. Affinity labeling of 3α-hydroxysteroid dehydrogenase with 3α-bromoacetoxyandrosterone and 11α-bromoacetoxyprogesterone: Isolation and sequence of active site peptides containing reactive cysteines; sequence confirmation using nucleotide sequence from a cDNA clone Journal of Biological Chemistry. 266: 8826-8834. PMID 2026597  1
1991 Askonas LJ, Ricigliano JW, Penning TM. The kinetic mechanism catalysed by homogeneous rat liver 3α-hydroxysteroid dehydrogenase. Evidence for binary and ternary dead-end complexes containing non-steroidal anti-inflammatory drugs Biochemical Journal. 278: 835-841. PMID 1898369  1
1991 Pawlowski JE, Huizinga M, Penning TM. Cloning and sequencing of the cDNA for rat liver 3α-hydroxysteroid/dihydrodiol dehydrogenase Journal of Biological Chemistry. 266: 8820-8825. PMID 1840601  1
1991 Penning TM, Thornton R, Ricigliano JW. Clues to the development of mechanism-based inactivators of 3α-hydroxysteroid dehydrogenase: comparison of steroidal and nonsteroidal Michael acceptors and epoxides Steroids. 56: 420-427. PMID 1788860 DOI: 10.1016/0039-128X(91)90030-Y  1
1991 Penning TM. Development of affinity labeling agents based on nonsteroidal anti-inflammatory drugs: Labeling of the nonsteroidal anti-inflammatory drug Biochemistry. 30: 11553-11560. PMID 1747374  1
1991 Penning TM, Ricigliano JW. Mechanism based inhibition of hydroxysteroid dehydrogenases Journal of Enzyme Inhibition and Medicinal Chemistry. 5: 165-198. PMID 1669446 DOI: 10.3109/14756369109080057  1
1991 Pawlowski J, Huizinga M, Penning TM. Isolation and partial characterization of a full-length cDNA clone for 3 α-hydroxysteroid dehydrogenase: A potential target enzyme for nonsteroidal anti-inflammatory drugs Agents and Actions. 34: 289-293. DOI: 10.1007/BF01993305  1
1990 Ricigliano JW, Penning TM. Evidence that enzyme-generated aromatic Michael acceptors covalently modify the nucleotide-binding site of 3α-hydroxysteroid dehydrogenase Biochemical Journal. 269: 749-755. PMID 2390066  1
1990 Penning TM, Sharp RB. Characterization of dihydrodiol dehydrdrogenase in human liver and lung Carcinogenesis. 11: 1203-1208. PMID 2197014 DOI: 10.1093/carcin/11.7.1203  1
1990 Penning TM, Sharp RB. Characterization of dihydrodiol dehydrogenase in human liver and lung Carcinogenesis. 11: 2083. DOI: 10.1093/carcin/11.11.2083  1
1989 Buller AL, Sharp RB, Penning TM. Characterization of Dihydrodiol Dehydrogenase in Rat H-4IIe Hepatoma Cells Cancer Research. 49: 6976-6980. PMID 2684404  1
1989 Penning TM, Sharp RB, Smithgall TE. Non-K-region o-quinones as enzyme-generated inactivators of dihydrodiol dehydrogenase Biochemistry. 28: 4505-4511. PMID 2669957  1
1989 Ricigliano JW, Penning TM. Synthesis and evaluation of non-steroidal mechanism-based inactivators of 3α-hydroxysteroid dehydrogenase Biochemical Journal. 262: 139-149. PMID 2640566  1
1988 Smithgall TE, Harvey RG, Penning TM. Spectroscopic identification of ortho-quinones as the products of polycylic aromatic trans-dihydrodiol oxidation catalyzed by dihydrodiol dehydrogenase. A potential route of proximate carcinogen metabolism Journal of Biological Chemistry. 263: 1814-1820. PMID 3276678  1
1988 Sharp RB, Penning TM. Inhibition of progesterone synthesis in normal and transformed human placental cells by tight binding inhibitors of 3β-hydroxysterioid dehydrogenase Steroids. 51: 441-457. PMID 3242170 DOI: 10.1016/0039-128X(88)90043-8  1
1988 Smithgall TE, Penning TM. Electrophoretic and immunochemical characterization of 3α-hydroxysteroid/dihydrodiol dehydrogenases of rat tissues Biochemical Journal. 254: 715-721. PMID 3196287  1
1988 Smithgall TE, Harvey RG, Penning TM. Oxidation of the trans-3,4-dihydrodiol metabolites of the potent carcinogen 7,12-dimethylbenz(a)anthracene and other benz(a)anthracene derivatives by 3a-hydroxysteroid-dihydrodiol dehydrogenase: Effects of methyl substitution on velocity and stereochemical course of frans-dihydrodiol oxidation Cancer Research. 48: 1227-1232. PMID 3124956  1
1987 Penning TM, Ivins JK. Radiochemical Detection of Dihydrodiol Dehydrogenase: Distribution of the Enzyme in Male Sprague-Dawley Rat Tissues and Its Sensitivity to Inhibition by Indomethacin and 6-Medroxyprogesterone Acetate Cancer Research. 47: 680-684. PMID 3542192  1
1987 Penning TM, Sharp RB. Prostaglandin dehydrogenase activity of purified rat liver 3α-hydroxysteroid dehydrogenase Biochemical and Biophysical Research Communications. 148: 646-652. PMID 3479982 DOI: 10.1016/0006-291X(87)90925-9  1
1987 Penning TM, Carlson KE, Sharp RB. Affinity-labelling of the anti-inflammatory drug and prostaglandin-binding site of 3α-hydroxysteroid dehydrogenase of rat liver cytosol with 17β- and 21-bromoacetoxysteroids Biochemical Journal. 245: 269-276. PMID 3478045  1
1986 Penning TM, Smithgall TE, Askonas LJ, Sharp RB. Rat liver 3α-hydroxysteroid dehydrogenase Steroids. 47: 223-247. PMID 3473753 DOI: 10.1016/0039-128X(86)90094-2  1
1986 Ricigliano JW, Penning TM. Active-site directed inactivation of rat ovarian 20α-hydroxysteroid dehydrogenase Biochemical Journal. 240: 717-723. PMID 3470004  1
1986 Penning TM. Indomethacin and glucocorticoid metabolism in rat liver cytosol Biochemical Pharmacology. 35: 4203-4209. PMID 3466590 DOI: 10.1016/0006-2952(86)90696-9  1
1986 Smithgall TE, Harvey RG, Penning TM. Regio- and stereospecificity of homogeneous 3α-hydroxysteroid-dihydrodiol dehydrogenase for trans-dihydrodiol metabolites of polycyclic aromatic hydrocarbons Journal of Biological Chemistry. 261: 6184-6191. PMID 3457793  1
1986 Smithgall TE, Penning TM. Inhibition of trans-dihydrodiol oxidation by the non-steroidal anti-inflammatory drugs Carcinogenesis. 7: 583-588. PMID 3457649 DOI: 10.1093/carcin/7.4.583  1
1985 Sharp RB, Senior MB, Penning TM. Potent inhibition of mammalian progesterone synthesis by 2α-cyanoprogesterone Biochemical Journal. 230: 587-594. PMID 3864439  1
1985 Smithgall TE, Penning TM. Sex Differences in Indomethacin-sensitive 3α-Hydroxysteroid Dehydrogenase of Rat Liver Cytosol Cancer Research. 45: 4946-4949. PMID 3861239  1
1985 Penning TM. Inhibition of 5β-dihydrocortisone reduction in rat liver cytosol: A rapid spectrophotometric screen for nonsteroidal anti-inflammatory drug potency Journal of Pharmaceutical Sciences. 74: 651-654. PMID 3860639  1
1985 Smithgall TE, Penning TM. Indomethacin-sensitive 3α-hydroxysteroid dehydrogenase in rat tissues Biochemical Pharmacology. 34: 831-835. PMID 3856432 DOI: 10.1016/0006-2952(85)90763-4  1
1985 Penning TM. Irreversible inhibition of Δ5-3-oxosteroid isomerase by 2-substituted progesterones Biochemical Journal. 226: 469-476. PMID 3838891  1
1985 Penning TM, Sharp RB, Krieger NR. Purification and properties of 3α-hydroxysteroid dehydrogenase from rat brain cytosol: Inhibition by nonsteroidal anti-inflammatory drugs and progestins Journal of Biological Chemistry. 260: 15266-15272. PMID 2933398  1
1985 Penning TM. A new approach to drug development: inhibitors of steroid hormone biosynthesis Trends in Pharmacological Sciences. 6: 460-462. DOI: 10.1016/0165-6147(85)90217-2  1
1985 Penning TM, Sharp RE, Krieger N. Purification and properties of 3α-hydroxysteroid dehydrogenase from rat brain cytosol Federation Proceedings. 44.  1
1984 Penning TM, Mukharji I, Barrows S, Talalay P. Purification and properties of a 3α-hydroxysteroid dehydrogenase of rat liver cytosol and its inhibition by anti-inflammatory drugs Biochemical Journal. 222: 601-611. PMID 6435601  1
1984 Penning TM. Initiation of chemical carcinogenesis and the 'aspirin-like' drugs Trends in Pharmacological Sciences. 5: 452-453. DOI: 10.1016/0165-6147(84)90502-9  1
1983 Penning TM, Talalay P. Inhibition of a major NAD(P)-linked oxidoreductase from rat liver cytosol by steroidal and nonsteroidal anti-inflammatory agents and by prostaglandins Proceedings of the National Academy of Sciences of the United States of America. 80: 4504-4508. PMID 6410393  1
1983 Penning TM. Design of suicide substrates: an approach to the development of highly selective enzyme inhibitors as drugs Trends in Pharmacological Sciences. 4: 212-217. DOI: 10.1016/0165-6147(83)90369-3  1
1982 Penning TM, Heller DN, Balasubramanian TM, Fenselau CC, Talalay P. Mass spectrometric studies of a modified active-site tetrapeptide from Δ-5-3-ketosteroid isomerase of Pseudomonas testosteroni Journal of Biological Chemistry. 257: 12589-12593. PMID 7130168  1
1982 Penning TM, Covey DF. Inactivation of Δ5-3-ketosteroid isomerase(s) from beef adrenal cortex by acetylenic ketosteroids Journal of Steroid Biochemistry. 16: 691-699. PMID 7098483 DOI: 10.1016/0022-4731(82)90106-6  1
1982 Penning TM. Inactivation of Δ5-3-ketosteroid isomerase(s) from beef adrenal cortex by β,γ-acetylenic ketosteroids Steroids. 39: 301-311. PMID 7090026 DOI: 10.1016/0039-128X(82)90149-0  1
1981 Penning TM, Covey DF, Talalay P. Inactivation of delta 5-3-oxo steroid isomerase with active-site-directed acetylenic steroids Biochemical Journal. 193: 217-227. PMID 7305923  1
1981 Penning TM, Covey DF, Talalay P. Irreversible inactivation of Δ5-3-ketosteroid isomerase of Pseudomonas testosteroni by acetylenic suicide substrates. Mechanism of formation and properties of the steroid-enzyme adduct Journal of Biological Chemistry. 256: 6842-6850. PMID 7240247  1
1981 Penning TM, Talalay P. Linkage of an acetylenic secosteroid suicide substrate to the active site of delta 5-3-ketosteroid isomerase. Isolation and characterization of a tetrapeptide Journal of Biological Chemistry. 256: 6851-6858. PMID 7016878  1
1980 Penning TM, Westbrook EM, Talalay P. On the number of steroid-binding sites of delta 5-3-oxosteroid isomerase European Journal of Biochemistry. 105: 461-469. PMID 7371643  1
1978 Smith DF, Penning TM, Ansari AQ, Munday KA, Akhtar M. Oestrogen-induced cholesterol and fatty acid biosynthesis in Xenopus laevis liver during vitellogenic response Biochemical Journal. 174: 353-361. PMID 708388  1
1977 Penning TM, Merry AH, Munday KA, Akhtar M. Studies on the biosynthesis, assembly and secretion of vitellogenin, an oestrogen induced multicomponent protein Biochemical Journal. 162: 157-170. PMID 849274  1
1973 Merry AH, Penning TM, Munday KA, Akhtar M. Oestrogen stimulated cholesterol and lipid synthesis in Xenopus laevis liver Biochemical Society Transactions. 1: 1326-1327. PMID 4802550  1
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