Vladlen Z. Slepak - Publications

Affiliations: 
University of Miami, Coral Gables, FL 
Area:
Pharmacology, Neuroscience Biology, Biochemistry

75 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Wang Q, Henry TAN, Pronin AN, Jang GF, Lubaczeuski C, Crabb JW, Bernal-Mizrachi E, Slepak VZ. The regulatory G protein signaling complex, Gβ5-R7, promotes glucose- and extracellular signal-stimulated insulin secretion. The Journal of Biological Chemistry. 295: 7213-7223. PMID 33516345 DOI: 10.1074/jbc.RA119.011534  0.48
2020 Wang Q, Henry TAN, Pronin AN, Jang GF, Lubaczeuski C, Crabb JW, Bernal-Mizrachi E, Slepak VZ. The regulatory G protein signaling complex, Gβ5-R7, promotes glucose- and extracellular signal stimulated insulin secretion. The Journal of Biological Chemistry. PMID 32229584 DOI: 10.1074/Jbc.Ra119.011534  0.48
2018 Dvoriantchikova G, Pronin A, Kurtenbach S, Toychiev A, Chou TH, Yee CW, Prindeville B, Tayou J, Porciatti V, Sagdullaev BT, Slepak VZ, Shestopalov VI. Pannexin 1 sustains the electrophysiological responsiveness of retinal ganglion cells. Scientific Reports. 8: 5797. PMID 29643381 DOI: 10.1038/S41598-018-23894-2  0.36
2017 Pronin A, Wang Q, Slepak VZ. Teaching an old drug new tricks: agonism, antagonism and biased signaling of pilocarpine through M3 muscarinic acetylcholine receptor. Molecular Pharmacology. PMID 28893976 DOI: 10.1124/Mol.117.109678  0.48
2017 Wang Q, Pronin AN, Levay K, Almaca J, Fornoni A, Caicedo A, Slepak VZ. Regulator of G protein signaling Gβ5-R7 is a crucial activator of muscarinic M3 receptor-stimulated insulin secretion. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28687610 DOI: 10.1096/Fj.201700197Rr  0.48
2017 Kolobynina KG, Solovyova VV, Levay K, Rizvanov AA, Slepak VZ. Correction: Emerging roles of the single EF-hand Ca2+ sensor tescalcin in the regulation of gene expression, cell growth and differentiation. Journal of Cell Science. 130: 521. PMID 28126899 DOI: 10.1242/Jcs.200378  0.48
2016 Kolobynina KG, Solovyova VV, Levay K, Rizvanov AA, Slepak VZ. Emerging roles of the single EF-hand Ca2+ sensor tescalcin in the regulation of gene expression, cell growth and differentiation. Journal of Cell Science. PMID 27609838 DOI: 10.1242/Jcs.191486  0.48
2016 Tayou J, Wang Q, Jang GF, Pronin AN, Orlandi C, Martemyanov KA, Crabb JW, Slepak VZ. Regulator of G-protein Signaling 7 (RGS7) can exist in a homo-oligomeric form that is regulated by Gαo and R7-binding protein. The Journal of Biological Chemistry. PMID 26895961 DOI: 10.1074/Jbc.M115.694075  0.48
2016 Sorokin DY, Kublanov IV, Gavrilov SN, Rojo D, Roman P, Golyshin PN, Slepak VZ, Smedile F, Ferrer M, Messina E, La Cono V, Yakimov MM. Elemental sulfur and acetate can support life of a novel strictly anaerobic haloarchaeon. The Isme Journal. 10: 240-52. PMID 25978546 DOI: 10.1038/Ismej.2015.79  1
2015 Karpinsky-Semper D, Tayou J, Levay K, Schuchardt BJ, Bhat V, Volmar CH, Farooq A, Slepak VZ. Helix 8 and the i3 loop of the muscarinic M3 receptor are crucial sites for its regulation by the Gβ5-RGS7 complex. Biochemistry. 54: 1077-88. PMID 25551629 DOI: 10.1021/Bi500980D  1
2015 Solovyeva VV, Kolobynina KG, Gomzikova MO, Tazetdinova LG, Zhuravleva MN, Slepak VZ, Rizvanov AA. Effect of tescalcin overexpression on osteogenic differentiation of human mesenchymal stem cells Genes and Cells. 10: 90-93.  1
2014 Pronin A, Levay K, Velmeshev D, Faghihi M, Shestopalov VI, Slepak VZ. Expression of olfactory signaling genes in the eye. Plos One. 9: e96435. PMID 24789354 DOI: 10.1371/Journal.Pone.0096435  1
2014 Levay K, Slepak VZ. Regulation of Cop9 signalosome activity by the EF-hand Ca2+-binding protein tescalcin. Journal of Cell Science. 127: 2448-59. PMID 24659803 DOI: 10.1242/Jcs.139592  1
2014 Karpinsky-Semper D, Volmar CH, Brothers SP, Slepak VZ. Differential effects of the Gβ5-RGS7 complex on muscarinic M3 receptor-induced Ca2+ influx and release. Molecular Pharmacology. 85: 758-68. PMID 24586057 DOI: 10.1124/Mol.114.091843  1
2014 Shestopalov VI, Slepak VZ. Molecular pathways of pannexin1-mediated neurotoxicity. Frontiers in Physiology. 5: 23. PMID 24575045 DOI: 10.3389/Fphys.2014.00023  1
2014 Križaj D, Ryskamp DA, Tian N, Tezel G, Mitchell CH, Slepak VZ, Shestopalov VI. From mechanosensitivity to inflammatory responses: new players in the pathology of glaucoma. Current Eye Research. 39: 105-19. PMID 24144321 DOI: 10.3109/02713683.2013.836541  1
2013 Yakimov MM, La Cono V, Slepak VZ, La Spada G, Arcadi E, Messina E, Borghini M, Monticelli LS, Rojo D, Barbas C, Golyshina OV, Ferrer M, Golyshin PN, Giuliano L. Microbial life in the Lake Medee, the largest deep-sea salt-saturated formation. Scientific Reports. 3: 3554. PMID 24352146 DOI: 10.1038/Srep03554  1
2013 La Cono V, La Spada G, Arcadi E, Placenti F, Smedile F, Ruggeri G, Michaud L, Raffa C, De Domenico E, Sprovieri M, Mazzola S, Genovese L, Giuliano L, Slepak VZ, Yakimov MM. Partaking of Archaea to biogeochemical cycling in oxygen-deficient zones of meromictic saline Lake Faro (Messina, Italy). Environmental Microbiology. 15: 1717-33. PMID 23253149 DOI: 10.1111/1462-2920.12060  1
2012 Mason B, Schmale M, Gibbs P, Miller MW, Wang Q, Levay K, Shestopalov V, Slepak VZ. Evidence for multiple phototransduction pathways in a reef-building coral. Plos One. 7: e50371. PMID 23227169 DOI: 10.1371/Journal.Pone.0050371  1
2012 Liapis E, Sandiford S, Wang Q, Gaidosh G, Motti D, Levay K, Slepak VZ. Subcellular localization of regulator of G protein signaling RGS7 complex in neurons and transfected cells. Journal of Neurochemistry. 122: 568-81. PMID 22640015 DOI: 10.1111/J.1471-4159.2012.07811.X  1
2012 Dvoriantchikova G, Ivanov D, Barakat D, Grinberg A, Wen R, Slepak VZ, Shestopalov VI. Genetic ablation of Pannexin1 protects retinal neurons from ischemic injury. Plos One. 7: e31991. PMID 22384122 DOI: 10.1371/Journal.Pone.0031991  1
2011 Wang Q, Levay K, Chanturiya T, Dvoriantchikova G, Anderson KL, Bianco SD, Ueta CB, Molano RD, Pileggi A, Gurevich EV, Gavrilova O, Slepak VZ. Targeted deletion of one or two copies of the G protein β subunit Gβ5 gene has distinct effects on body weight and behavior in mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 3949-57. PMID 21804131 DOI: 10.1096/Fj.11-190157  1
2011 Dong Q, Brulc JM, Iovieno A, Bates B, Garoutte A, Miller D, Revanna KV, Gao X, Antonopoulos DA, Slepak VZ, Shestopalov VI. Diversity of bacteria at healthy human conjunctiva. Investigative Ophthalmology & Visual Science. 52: 5408-13. PMID 21571682 DOI: 10.1167/Iovs.10-6939  1
2010 Sandiford SL, Wang Q, Levay K, Buchwald P, Slepak VZ. Molecular organization of the complex between the muscarinic M3 receptor and the regulator of G protein signaling, Gbeta(5)-RGS7. Biochemistry. 49: 4998-5006. PMID 20443543 DOI: 10.1021/Bi100080P  1
2010 Levay K, Slepak VZ. Up- or downregulation of tescalcin in HL-60 cells is associated with their differentiation to either granulocytic or macrophage-like lineage. Experimental Cell Research. 316: 1254-62. PMID 20060826 DOI: 10.1016/J.Yexcr.2010.01.007  1
2009 Slepak VZ. Structure, function, and localization of Gβ5-RGS complexes. Progress in Molecular Biology and Translational Science. 86: 157-203. PMID 20374716 DOI: 10.1016/S1877-1173(09)86006-7  1
2009 Sandiford SL, Slepak VZ. The Gbeta5-RGS7 complex selectively inhibits muscarinic M3 receptor signaling via the interaction between the third intracellular loop of the receptor and the DEP domain of RGS7. Biochemistry. 48: 2282-9. PMID 19182865 DOI: 10.1021/Bi801989C  1
2009 Rosenzweig DH, Nair KS, Levay K, Peshenko IV, Crabb JW, Dizhoor AM, Slepak VZ. Interaction of retinal guanylate cyclase with the alpha subunit of transducin: potential role in transducin localization. The Biochemical Journal. 417: 803-12. PMID 18840097 DOI: 10.1042/Bj20081513  1
2008 Grabowska D, Jayaraman M, Kaltenbronn KM, Sandiford SL, Wang Q, Jenkins S, Slepak VZ, Smith Y, Blumer KJ. Postnatal induction and localization of R7BP, a membrane-anchoring protein for regulator of G protein signaling 7 family-Gbeta5 complexes in brain. Neuroscience. 151: 969-82. PMID 18248908 DOI: 10.1016/J.Neuroscience.2007.11.045  1
2007 Levay K, Slepak VZ. Tescalcin is an essential factor in megakaryocytic differentiation associated with Ets family gene expression. The Journal of Clinical Investigation. 117: 2672-83. PMID 17717601 DOI: 10.1172/Jci27465  1
2007 Slepak TI, Tang M, Slepak VZ, Lai K. Involvement of endoplasmic reticulum stress in a novel Classic Galactosemia model. Molecular Genetics and Metabolism. 92: 78-87. PMID 17643331 DOI: 10.1016/J.Ymgme.2007.06.005  1
2007 Narayanan V, Sandiford SL, Wang Q, Keren-Raifman T, Levay K, Slepak VZ. Intramolecular interaction between the DEP domain of RGS7 and the Gbeta5 subunit. Biochemistry. 46: 6859-70. PMID 17511476 DOI: 10.1021/Bi700524W  1
2007 Rosenzweig DH, Nair KS, Wei J, Wang Q, Garwin G, Saari JC, Chen CK, Smrcka AV, Swaroop A, Lem J, Hurley JB, Slepak VZ. Subunit dissociation and diffusion determine the subcellular localization of rod and cone transducins. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 5484-94. PMID 17507570 DOI: 10.1523/Jneurosci.1421-07.2007  0.48
2007 Hanson SM, Cleghorn WM, Francis DJ, Vishnivetskiy SA, Raman D, Song X, Nair KS, Slepak VZ, Klug CS, Gurevich VV. Arrestin mobilizes signaling proteins to the cytoskeleton and redirects their activity. Journal of Molecular Biology. 368: 375-87. PMID 17359998 DOI: 10.1016/J.Jmb.2007.02.053  1
2006 Ames JB, Levay K, Wingard JN, Lusin JD, Slepak VZ. Structural basis for calcium-induced inhibition of rhodopsin kinase by recoverin. The Journal of Biological Chemistry. 281: 37237-45. PMID 17020884 DOI: 10.1074/Jbc.M606913200  0.48
2005 Nair KS, Hanson SM, Mendez A, Gurevich EV, Kennedy MJ, Shestopalov VI, Vishnivetskiy SA, Chen J, Hurley JB, Gurevich VV, Slepak VZ. Light-dependent redistribution of arrestin in vertebrate rods is an energy-independent process governed by protein-protein interactions. Neuron. 46: 555-67. PMID 15944125 DOI: 10.1016/J.Neuron.2005.03.023  0.52
2005 Nair KS, Mendez A, Blumer JB, Rosenzweig DH, Slepak VZ. The presence of a Leu-Gly-Asn repeat-enriched protein (LGN), a putative binding partner of transducin, in ROD photoreceptors. Investigative Ophthalmology & Visual Science. 46: 383-9. PMID 15623799 DOI: 10.1167/Iovs.04-1006  1
2004 Witherow DS, Slepak VZ. Biochemical purification and functional analysis of complexes between the G-protein subunit Gbeta5 and RGS proteins. Methods in Enzymology. 390: 149-62. PMID 15488176 DOI: 10.1016/S0076-6879(04)90010-9  1
2003 Gutierrez-Ford C, Levay K, Gomes AV, Perera EM, Som T, Kim YM, Benovic JL, Berkovitz GD, Slepak VZ. Characterization of tescalcin, a novel EF-hand protein with a single Ca2+-binding site: metal-binding properties, localization in tissues and cells, and effect on calcineurin. Biochemistry. 42: 14553-65. PMID 14661968 DOI: 10.1021/Bi034870F  1
2003 Balasubramanian N, Slepak VZ. Light-mediated activation of Rac-1 in photoreceptor outer segments. Current Biology : Cb. 13: 1306-10. PMID 12906790 DOI: 10.1016/S0960-9822(03)00511-6  1
2003 Witherow DS, Slepak VZ. A novel kind of G protein heterodimer: the G beta5-RGS complex. Receptors & Channels. 9: 205-12. PMID 12775340 DOI: 10.1080/10606820308239  1
2003 Witherow DS, Tovey SC, Wang Q, Willars GB, Slepak VZ. G beta 5.RGS7 inhibits G alpha q-mediated signaling via a direct protein-protein interaction. The Journal of Biological Chemistry. 278: 21307-13. PMID 12670932 DOI: 10.1074/Jbc.M212884200  1
2003 Rishal I, Keren-Raifman T, Yakubovich D, Ivanina T, Dessauer CW, Slepak VZ, Dascal N. Na+ promotes the dissociation between Galpha GDP and Gbeta gamma, activating G protein-gated K+ channels. The Journal of Biological Chemistry. 278: 3840-5. PMID 12488455 DOI: 10.1074/Jbc.C200605200  1
2002 Hausmann ON, Hu WH, Keren-Raifman T, Witherow DS, Wang Q, Levay K, Frydel B, Slepak VZ, Bethea JR. Spinal cord injury induces expression of RGS7 in microglia/macrophages in rats European Journal of Neuroscience. 15: 602-612. PMID 11886441 DOI: 10.1046/J.1460-9568.2002.01916.X  1
2002 Nair KS, Balasubramanian N, Slepak VZ. Signal-dependent translocation of transducin, RGS9-1-Gbeta5L complex, and arrestin to detergent-resistant membrane rafts in photoreceptors. Current Biology : Cb. 12: 421-5. PMID 11882295 DOI: 10.1016/S0960-9822(02)00691-7  1
2001 Balasubramanian N, Levay K, Keren-Raifman T, Faurobert E, Slepak VZ. Phosphorylation of the regulator of G protein signaling RGS9-1 by protein kinase A is a potential mechanism of light- and Ca2+-mediated regulation of G protein function in photoreceptors. Biochemistry. 40: 12619-27. PMID 11601986 DOI: 10.1021/Bi015624B  1
2001 Keren-Raifman T, Bera AK, Zveig D, Peleg S, Witherow DS, Slepak VZ, Dascal N. Expression levels of RGS7 and RGS4 proteins determine the mode of regulation of the G protein-activated K(+) channel and control regulation of RGS7 by G beta 5. Febs Letters. 492: 20-8. PMID 11248230 DOI: 10.1016/S0014-5793(01)02220-7  1
2000 Witherow DS, Wang Q, Levay K, Cabrera JL, Chen J, Willars GB, Slepak VZ. Complexes of the G protein subunit gbeta 5 with the regulators of G protein signaling RGS7 and RGS9. Characterization in native tissues and in transfected cells. The Journal of Biological Chemistry. 275: 24872-80. PMID 10840031 DOI: 10.1074/Jbc.M001535200  1
2000 Slepak VZ. Application of surface plasmon resonance for analysis of protein-protein interactions in the G protein-mediated signal transduction pathway Journal of Molecular Recognition. 13: 20-26. PMID 10679893 DOI: 10.1002/(Sici)1099-1352(200001/02)13:1<20::Aid-Jmr485>3.0.Co;2-N  1
1999 Levay K, Cabrera JL, Satpaev DK, Slepak VZ. Gbeta5 prevents the RGS7-Galphao interaction through binding to a distinct Ggamma-like domain found in RGS7 and other RGS proteins. Proceedings of the National Academy of Sciences of the United States of America. 96: 2503-7. PMID 10051672 DOI: 10.1073/Pnas.96.5.2503  1
1998 Craft CM, Xu J, Slepak VZ, Zhan-Poe X, Zhu X, Brown B, Lolley RN. PhLPs and PhLOPs in the phosducin family of Gβγ binding proteins Biochemistry. 37: 15758-15772. PMID 9843381 DOI: 10.1021/Bi980921A  1
1998 Levay K, Satpaev DK, Pronin AN, Benovic JL, Slepak VZ. Localization of the sites for Ca2+-binding proteins on G protein- coupled receptor kinases Biochemistry. 37: 13650-13659. PMID 9753452 DOI: 10.1021/Bi980998Z  1
1998 Cabrera JL, de Freitas F, Satpaev DK, Slepak VZ. Identification of the Gbeta5-RGS7 protein complex in the retina. Biochemical and Biophysical Research Communications. 249: 898-902. PMID 9731233 DOI: 10.1006/Bbrc.1998.9218  1
1998 Satpaev DK, Chen CK, Scotti A, Simon MI, Hurley JB, Slepak VZ. Autophosphorylation and ADP regulate the Ca2+-dependent interaction of recoverin with rhodopsin kinase. Biochemistry. 37: 10256-62. PMID 9665733 DOI: 10.1021/Bi9804986  1
1998 Cabrera JL, De Freitag F, Chen J, Slepak VZ. Forms of g protein β subunit gβ5 expressed in retina Faseb Journal. 12.  1
1997 Yu B, Slepak VZ, Simon MI. Characterization of a Goalpha mutant that binds xanthine nucleotides. The Journal of Biological Chemistry. 272: 18015-9. PMID 9218429 DOI: 10.1074/Jbc.272.29.18015  1
1997 Pronin AN, Satpaev DK, Slepak VZ, Benovic JL. Regulation of g protein-coupled receptor kinases by calmodulin and localization of the calmodulin binding domain Faseb Journal. 11. DOI: 10.1074/Jbc.272.29.18273  1
1997 Slepak VZ, Chen CK, Faurobert E, Simon MI, Hurley JB. Rhodopsin kinase - recoverin interaction on biacore Investigative Ophthalmology and Visual Science. 38: S478.  1
1997 Pronin AN, Satpaev DK, Slepak VZ, Benovic JL. Regulation of g protein-coupled receptor kinases by calmodulin and localization of the calmodulin binding domain Faseb Journal. 11.  1
1997 Craft CM, Xu J, Slepak VZ, Brown B, Zhan X, Simon- MI, Lolley RN. PhLPs and PhLOPs in the phosducin family of gβy binding proteins Investigative Ophthalmology and Visual Science. 38: S478.  1
1996 Doupnik CA, Dessauer CW, Slepak VZ, Gilman AG, Davidson N, Lester HA. Time resolved kinetics of direct G beta 1 gamma 2 interactions with the carboxyl terminus of Kir3.4 inward rectifier K+ channel subunits. Neuropharmacology. 35: 923-31. PMID 8938723 DOI: 10.1016/0028-3908(96)00125-6  1
1996 Watson AJ, Aragay AM, Slepak VZ, Simon MI. A novel form of the G protein β subunit Gβ5 is specifically expressed in the vertebrate retina Journal of Biological Chemistry. 271: 28154-28160. PMID 8910430 DOI: 10.1074/Jbc.271.45.28154  1
1995 Slepak VZ, Katz A, Simon MI. Functional analysis of a dominant negative mutant of Gαi2 Journal of Biological Chemistry. 270: 4037-4041. PMID 7876152 DOI: 10.1074/Jbc.270.8.4037  1
1995 Slepak VZ, Artemyev NO, Zhu Y, Dumke CL, Sabacan L, Sondek J, Hamm HE, Bownds MD, Arshavsky VY. An effector site that stimulates G-protein GTPase in photoreceptors Journal of Biological Chemistry. 270: 14319-14324. PMID 7782290 DOI: 10.1074/Jbc.270.24.14319  1
1995 Xu J, Wu D, Slepak VZ, Simon MI. The N terminus of phosducin is involved in binding of βγ subunits of G protein Proceedings of the National Academy of Sciences of the United States of America. 92: 2086-2090. PMID 7534410 DOI: 10.1073/Pnas.92.6.2086  1
1993 Slepak VZ, Wilkie TM, Simon MI. Mutational analysis of G protein alpha subunit G(o) alpha expressed in Escherichia coli. The Journal of Biological Chemistry. 268: 1414-23. PMID 8419342  1
1993 Slepak VZ, Quick MW, Aragay AM, Davidson N, Lester HA, Simon MI. Random mutagenesis of G protein alpha subunit G(o)alpha. Mutations altering nucleotide binding. The Journal of Biological Chemistry. 268: 21889-94. PMID 8408043  1
1991 Wilkie TM, Scherle PA, Strathmann MP, Slepak VZ, Simon MI. Characterization of G-protein alpha subunits in the Gq class: expression in murine tissues and in stromal and hematopoietic cell lines. Proceedings of the National Academy of Sciences of the United States of America. 88: 10049-53. PMID 1946421 DOI: 10.1073/Pnas.88.22.10049  1
1991 Amatruda TT, Steele DA, Slepak VZ, Simon MI. Gα16, a G protein α subunit specifically expressed in hematopoietic cells Proceedings of the National Academy of Sciences of the United States of America. 88: 5587-5591. PMID 1905813 DOI: 10.1073/Pnas.88.13.5587  1
1989 Slepak VZ, Pronin AN, Kiselyov OG, Voeikov VL, Frolova EI, Lipkin VM. Structure and function of the α-subunit of the GTP-binding protein Go from bovine cerebellum Journal of Protein Chemistry. 8: 436-438. PMID 2506883 DOI: 10.1007/Bf01674315  1
1989 Levina NB, Slepak VZ, Kiselev OG, Shemiakin VV, Khokhlachev AA. Use of electroblotting as a method for preparing samples of proteins and their fragments for microsequencing Bioorganicheskaia Khimiia. 15: 24-31. PMID 2500936  1
1987 Ovchinnikov IA, Slepak VZ, Pronin AN, Shlenskiǐ AB, Levina NB. G39, a GTP-binding protein from the bovine cerebellum. Amino acid sequence and nucleotide sequence of corresponding cDNA Doklady Akademii Nauk Sssr. 297: 1006-1009. PMID 3128437  1
1987 Ovchinnikov YuA, Slepak VZ, Pronin AN, Shlensky AB, Levina NB, Voeikov VL, Lipkin VM. Primary structure of bovine cerebellum GTP-binding protein G39 and its effect on the adenylate cyclase system. Febs Letters. 226: 91-5. PMID 3121394 DOI: 10.1016/0014-5793(87)80557-4  1
1987 Voeǐkov VL, Pronin AN, Slepak VZ, Chestukhin AN, Shlenskiǐ AB. High molecular weight forms of GTP-binding regulatory proteins from the bovine cerebellum Biokhimiya. 52: 1766-1769. PMID 2830911  1
1987 Ovchinnikov YA, Slepak VZ, Pronin AN, Shlenskii AB, Levina NB, Voeikov VL, Bystrov NS, Severtsova IV, Lipkin VM. G39, GTP-binding protein from bovine cerebellum. Amino acid sequence and nucleotide sequence of the corresponding cDNA Doklady Biochemistry. 297: 404-406.  1
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