| Year |
Citation |
Score |
| 2021 |
Liao Z, Gingras AR, Lagarrigue F, Ginsberg MH, Shattil SJ. Optogenetic-based Localization of Talin to the Plasma Membrane Promotes Activation of β3 Integrins. The Journal of Biological Chemistry. 100675. PMID 33865854 DOI: 10.1016/j.jbc.2021.100675 |
0.312 |
|
| 2020 |
Wen L, Marki A, Roy P, McArdle S, Sun H, Fan Z, Gingras AR, Ginsberg MH, Ley K. Kindlin-3 recruitment to the plasma membrane precedes high affinity β2 integrin and neutrophil arrest from rolling. Blood. PMID 32777822 DOI: 10.1182/Blood.2019003446 |
0.391 |
|
| 2020 |
Lagarrigue F, Paul DS, Gingras AR, Valadez AJ, Sun H, Lin J, Cuevas MN, Ablack JNG, Lopez Ramirez MA, Bergmeier W, Ginsberg MH. Talin1 is the Principal Platelet Rap1 Effector of Integrin Activation. Blood. PMID 32518959 DOI: 10.1182/Blood.2020005348 |
0.396 |
|
| 2020 |
Gingras AR, Ginsberg MH. Signal Transduction: Physical Deformation of the Membrane Activates Integrins. Current Biology : Cb. 30: R397-R400. PMID 32369751 DOI: 10.1016/J.Cub.2020.02.068 |
0.353 |
|
| 2020 |
Wen L, Marki A, Roy P, McArdle S, Sun H, Fan Z, Gingras AR, Ginsberg MH, Ley K. Recruitment of kindlin‐3 to plasma membrane through its PH domain precedes high affinity β 2 integrin activation and neutrophil arrest The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.02524 |
0.335 |
|
| 2019 |
Sun H, Fan Z, Gingras AR, Lopez-Ramirez MA, Ginsberg MH, Ley K. Frontline Science: A flexible kink in the transmembrane domain impairs β2 integrin extension and cell arrest from rolling. Journal of Leukocyte Biology. PMID 31475386 DOI: 10.1002/Jlb.1Hi0219-073Rr |
0.384 |
|
| 2019 |
Gingras AR, Lagarrigue F, Cuevas MN, Valadez AJ, Zorovich M, McLaughlin W, Lopez-Ramirez MA, Seban N, Ley K, Kiosses WB, Ginsberg MH. Rap1 binding and a lipid-dependent helix in talin F1 domain promote integrin activation in tandem. The Journal of Cell Biology. PMID 30988001 DOI: 10.1083/Jcb.201810061 |
0.36 |
|
| 2019 |
Fan Z, Kiosses WB, Sun H, Orecchioni M, Ghosheh Y, Zajonc DM, Arnaout MA, Gutierrez E, Groisman A, Ginsberg MH, Ley K. High-Affinity Bent β-Integrin Molecules in Arresting Neutrophils Face Each Other through Binding to ICAMs In cis. Cell Reports. 26: 119-130.e5. PMID 30605669 DOI: 10.1016/J.Celrep.2018.12.038 |
0.416 |
|
| 2018 |
Lopez-Ramirez MA, Pham A, Girard R, Wyseure T, Hale P, Yamashita A, Koskimäki J, Polster S, Saadat L, Romero IA, Esmon CT, Lagarrigue F, Awad IA, Mosnier LO, Ginsberg MH. Cerebral cavernous malformations form an anticoagulant vascular domain. Blood. PMID 30442679 DOI: 10.1182/Blood-2018-06-856062 |
0.307 |
|
| 2018 |
Lagarrigue F, Gingras AR, Paul DS, Valadez AJ, Cuevas MN, Sun H, Lopez-Ramirez MA, Goult BT, Shattil SJ, Bergmeier W, Ginsberg MH. Rap1 binding to the talin 1 F0 domain makes a minimal contribution to murine platelet GPIIb-IIIa activation. Blood Advances. 2: 2358-2368. PMID 30242097 DOI: 10.1182/Bloodadvances.2018020487 |
0.407 |
|
| 2018 |
Klann JE, Kim SH, Remedios KA, He Z, Metz PJ, Lopez J, Tysl T, Olvera JG, Ablack JN, Cantor JM, Boland BS, Yeo G, Zheng Y, Lu LF, Bui JD, ... Ginsberg MH, et al. Integrin Activation Controls Regulatory T Cell-Mediated Peripheral Tolerance. Journal of Immunology (Baltimore, Md. : 1950). PMID 29703862 DOI: 10.4049/Jimmunol.1800112 |
0.412 |
|
| 2018 |
Sun H, Lagarrigue F, Gingras AR, Fan Z, Ley K, Ginsberg MH. Transmission of integrin β7 transmembrane domain topology enables gut lymphoid tissue development. The Journal of Cell Biology. PMID 29535192 DOI: 10.1083/Jcb.201707055 |
0.397 |
|
| 2017 |
Borst AJ, James ZM, Zagotta WN, Ginsberg M, Rey FA, DiMaio F, Backovic M, Veesler D. The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human αVβ3 Integrin via Steric Hindrance. Structure (London, England : 1993). PMID 29033288 DOI: 10.1016/J.Str.2017.09.007 |
0.368 |
|
| 2017 |
Klann JE, Remedios KA, Kim SH, Metz PJ, Lopez J, Mack LA, Zheng Y, Ginsberg MH, Petrich BG, Chang JT. Talin Plays a Critical Role in the Maintenance of the Regulatory T Cell Pool. Journal of Immunology (Baltimore, Md. : 1950). PMID 28515282 DOI: 10.4049/Jimmunol.1601165 |
0.336 |
|
| 2017 |
Rothmeier AS, Marchese P, Langer F, Kamikubo Y, Schaffner F, Cantor J, Ginsberg MH, Ruggeri ZM, Ruf W. Tissue Factor Prothrombotic Activity Is Regulated by Integrin-arf6 Trafficking. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 28495929 DOI: 10.1161/Atvbaha.117.309315 |
0.309 |
|
| 2017 |
Ye F, Yang C, Kim J, MacNevin CJ, Hahn KM, Park D, Ginsberg MH, Kim C. Epigallocatechin gallate has pleiotropic effects on transmembrane signaling by altering the embedding of transmembrane domains. The Journal of Biological Chemistry. PMID 28487468 DOI: 10.1074/Jbc.C117.787309 |
0.427 |
|
| 2016 |
Gingras AR, Puzon-McLaughlin W, Bobkov AA, Ginsberg MH. Structural Basis of Dimeric Rasip1 RA Domain Recognition of the Ras Subfamily of GTP-Binding Proteins. Structure (London, England : 1993). PMID 27839947 DOI: 10.1016/J.Str.2016.10.001 |
0.34 |
|
| 2016 |
Fan Z, McArdle S, Marki A, Mikulski Z, Gutierrez E, Engelhardt B, Deutsch U, Ginsberg M, Groisman A, Ley K. Neutrophil recruitment limited by high-affinity bent β2 integrin binding ligand in cis. Nature Communications. 7: 12658. PMID 27578049 DOI: 10.1038/Ncomms12658 |
0.371 |
|
| 2016 |
Abplanalp WT, Conklin DJ, Cantor JM, Ginsberg MH, Wysoczynski M, Bhatnagar A, O'Toole TE. Enhanced Integrin α4β1-Mediated Adhesion Contributes to a Mobilization Defect of Endothelial Progenitor Cells in Diabetes. Diabetes. PMID 27495221 DOI: 10.2337/Db16-0634 |
0.351 |
|
| 2016 |
Schmidt T, Ye F, Situ AJ, An W, Ginsberg MH, Ulmer TS. A Conserved Ectodomain-Transmembrane Domain Linker Motif Tunes the Allosteric Regulation of Cell Surface Receptors. The Journal of Biological Chemistry. PMID 27365391 DOI: 10.1074/Jbc.M116.733683 |
0.372 |
|
| 2016 |
Ligarrigue F, Kim C, Ginsberg MH. The Rap1-RIAM-talin axis of integrin activation and blood cell function. Blood. PMID 27207789 DOI: 10.1182/Blood-2015-12-638700 |
0.46 |
|
| 2016 |
de la Ballina LR, Cano-Crespo S, González-Muñoz E, Bial S, Estrach S, Cailleteau L, Tissot F, Daniel H, Zorzano A, Ginsberg MH, Palacin M, Féral CC. Amino Acid Transport Associated to Cluster of Differentiation 98 Heavy Chain (CD98hc) is at the Crossroad of Oxidative Stress and Amino Acid Availability. The Journal of Biological Chemistry. PMID 26945935 DOI: 10.1074/Jbc.M115.704254 |
0.322 |
|
| 2016 |
de Kreuk BJ, Gingras AR, Knight JD, Liu JJ, Gingras AC, Ginsberg MH. Heart of glass anchors Rasip1 at endothelial cell-cell junctions to support vascular integrity. Elife. 5. PMID 26780829 DOI: 10.7554/Elife.11394 |
0.405 |
|
| 2015 |
Wurtzel JG, Lee S, Singhal SS, Awasthi S, Ginsberg MH, Goldfinger LE. RLIP76 regulates Arf6-dependent cell spreading and migration by linking ARNO with activated R-Ras at recycling endosomes. Biochemical and Biophysical Research Communications. 467: 785-91. PMID 26498519 DOI: 10.1016/J.Bbrc.2015.10.064 |
0.334 |
|
| 2015 |
Lagarrigue F, Vikas Anekal P, Lee HS, Bachir AI, Ablack JN, Horwitz AF, Ginsberg MH. A RIAM/lamellipodin-talin-integrin complex forms the tip of sticky fingers that guide cell migration. Nature Communications. 6: 8492. PMID 26419705 DOI: 10.1038/Ncomms9492 |
0.374 |
|
| 2015 |
Dai A, Ye F, Taylor DW, Hu G, Ginsberg MH, Taylor KA. The structure of a full-length membrane-embedded integrin bound to a physiological ligand. The Journal of Biological Chemistry. PMID 26391523 DOI: 10.1074/Jbc.M115.682377 |
0.366 |
|
| 2015 |
Zhang P, Ye F, Bastidas AC, Kornev AP, Wu J, Ginsberg MH, Taylor SS. An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes. Structure (London, England : 1993). PMID 26278174 DOI: 10.1016/J.Str.2015.07.007 |
0.321 |
|
| 2015 |
Yago T, Petrich BG, Zhang N, Liu Z, Shao B, Ginsberg MH, McEver RP. Blocking neutrophil integrin activation prevents ischemia-reperfusion injury. The Journal of Experimental Medicine. PMID 26169939 DOI: 10.1084/Jem.20142358 |
0.383 |
|
| 2015 |
Rothmeier AS, Marchese P, Petrich BG, Furlan-Freguia C, Ginsberg MH, Ruggeri ZM, Ruf W. Caspase-1-mediated pathway promotes generation of thromboinflammatory microparticles. The Journal of Clinical Investigation. 125: 1471-84. PMID 25705884 DOI: 10.1172/Jci79329 |
0.376 |
|
| 2015 |
Cantor JM, Rose DM, Slepak M, Ginsberg MH. Fine-tuning Tumor Immunity with Integrin Trans-regulation. Cancer Immunology Research. 3: 661-7. PMID 25600437 DOI: 10.1158/2326-6066.Cir-13-0226 |
0.354 |
|
| 2015 |
Liao Z, Kato H, Pandey M, Cantor JM, Ablooglu AJ, Ginsberg MH, Shattil SJ. Interaction of kindlin-2 with integrin β3 promotes outside-in signaling responses by the αVβ3 vitronectin receptor. Blood. 125: 1995-2004. PMID 25587038 DOI: 10.1182/Blood-2014-09-603035 |
0.355 |
|
| 2014 |
Ginsberg MH. Integrin activation. Bmb Reports. 47: 655-9. PMID 25388208 DOI: 10.5483/BMBRep.2014.47.12.241 |
0.352 |
|
| 2014 |
Estrach S, Lee SA, Boulter E, Pisano S, Errante A, Tissot FS, Cailleteau L, Pons C, Ginsberg MH, Féral CC. CD98hc (SLC3A2) loss protects against ras-driven tumorigenesis by modulating integrin-mediated mechanotransduction. Cancer Research. 74: 6878-89. PMID 25267066 DOI: 10.1158/0008-5472.Can-14-0579 |
0.338 |
|
| 2014 |
Ye F, Lagarrigue F, Ginsberg MH. SnapShot: talin and the modular nature of the integrin adhesome. Cell. 156: 1340-1340.e1. PMID 24630731 DOI: 10.1016/J.Cell.2014.02.048 |
0.37 |
|
| 2014 |
Kasirer-Friede A, Kang J, Kahner B, Ye F, Ginsberg MH, Shattil SJ. ADAP interactions with talin and kindlin promote platelet integrin αIIbβ3 activation and stable fibrinogen binding. Blood. 123: 3156-65. PMID 24523237 DOI: 10.1182/Blood-2013-08-520627 |
0.475 |
|
| 2014 |
Ye F, Snider AK, Ginsberg MH. Talin and kindlin: the one-two punch in integrin activation. Frontiers of Medicine. 8: 6-16. PMID 24477625 DOI: 10.1007/S11684-014-0317-3 |
0.44 |
|
| 2014 |
Rothmeier AS, Marchese P, Furlan-Freguia C, Petrich BG, Ginsberg MH, Ruggeri ZM, Ruf W. A Crucial Role for Caspase 1 in Thrombo-Inflammatory Microparticle Release Blood. 124: 2806-2806. DOI: 10.1182/Blood.V124.21.2806.2806 |
0.349 |
|
| 2013 |
Ye F, Petrich BG, Anekal P, Lefort CT, Kasirer-Friede A, Shattil SJ, Ruppert R, Moser M, Fässler R, Ginsberg MH. The mechanism of kindlin-mediated activation of integrin αIIbβ3. Current Biology : Cb. 23: 2288-95. PMID 24210614 DOI: 10.1016/J.Cub.2013.09.050 |
0.417 |
|
| 2013 |
Gingras AR, Ye F, Ginsberg MH. Reconstructing integrin activation in vitro. Methods in Molecular Biology (Clifton, N.J.). 1046: 1-17. PMID 23868579 DOI: 10.1007/978-1-62703-538-5_1 |
0.457 |
|
| 2013 |
Gingras AR, Puzon-McLaughlin W, Ginsberg MH. The structure of the ternary complex of Krev interaction trapped 1 (KRIT1) bound to both the Rap1 GTPase and the heart of glass (HEG1) cytoplasmic tail. The Journal of Biological Chemistry. 288: 23639-49. PMID 23814056 DOI: 10.1074/Jbc.M113.462911 |
0.361 |
|
| 2013 |
Lee HS, Anekal P, Lim CJ, Liu CC, Ginsberg MH. Two modes of integrin activation form a binary molecular switch in adhesion maturation. Molecular Biology of the Cell. 24: 1354-62. PMID 23468527 DOI: 10.1091/Mbc.E12-09-0695 |
0.422 |
|
| 2013 |
Zou W, Izawa T, Zhu T, Chappel J, Otero K, Monkley SJ, Critchley DR, Petrich BG, Morozov A, Ginsberg MH, Teitelbaum SL. Talin1 and Rap1 are critical for osteoclast function. Molecular and Cellular Biology. 33: 830-44. PMID 23230271 DOI: 10.1128/Mcb.00790-12 |
0.312 |
|
| 2012 |
Wang S, Watanabe T, Matsuzawa K, Katsumi A, Kakeno M, Matsui T, Ye F, Sato K, Murase K, Sugiyama I, Kimura K, Mizoguchi A, Ginsberg MH, Collard JG, Kaibuchi K. Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration. The Journal of Cell Biology. 199: 331-45. PMID 23071154 DOI: 10.1083/Jcb.201202041 |
0.397 |
|
| 2012 |
Gingras AR, Liu JJ, Ginsberg MH. Structural basis of the junctional anchorage of the cerebral cavernous malformations complex. The Journal of Cell Biology. 199: 39-48. PMID 23007647 DOI: 10.1083/Jcb.201205109 |
0.358 |
|
| 2012 |
Kim C, Ye F, Hu X, Ginsberg MH. Talin activates integrins by altering the topology of the β transmembrane domain. The Journal of Cell Biology. 197: 605-11. PMID 22641344 DOI: 10.1083/Jcb.201112141 |
0.358 |
|
| 2012 |
Kahner BN, Kato H, Banno A, Ginsberg MH, Shattil SJ, Ye F. Kindlins, integrin activation and the regulation of talin recruitment to αIIbβ3. Plos One. 7: e34056. PMID 22457811 DOI: 10.1371/Journal.Pone.0034056 |
0.723 |
|
| 2012 |
Lefort CT, Rossaint J, Moser M, Petrich BG, Zarbock A, Monkley SJ, Critchley DR, Ginsberg MH, Fässler R, Ley K. Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation. Blood. 119: 4275-82. PMID 22431571 DOI: 10.1182/Blood-2011-08-373118 |
0.41 |
|
| 2012 |
Banno A, Goult BT, Lee H, Bate N, Critchley DR, Ginsberg MH. Subcellular localization of talin is regulated by inter-domain interactions. The Journal of Biological Chemistry. 287: 13799-812. PMID 22351767 DOI: 10.1074/Jbc.M112.341214 |
0.675 |
|
| 2012 |
Kim C, Schmidt T, Cho EG, Ye F, Ulmer TS, Ginsberg MH. Basic amino-acid side chains regulate transmembrane integrin signalling. Nature. 481: 209-13. PMID 22178926 DOI: 10.1038/Nature10697 |
0.303 |
|
| 2012 |
McDonald DA, Shi C, Shenkar R, Stockton RA, Liu F, Ginsberg MH, Marchuk DA, Awad IA. Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease. Stroke; a Journal of Cerebral Circulation. 43: 571-4. PMID 22034008 DOI: 10.1161/Strokeaha.111.625467 |
0.31 |
|
| 2012 |
Ye F, Kim C, Ginsberg MH. Reconstruction of integrin activation. Blood. 119: 26-33. PMID 21921044 DOI: 10.1182/Blood-2011-04-292128 |
0.378 |
|
| 2012 |
Rothmeier AS, Furlan-Freguia C, Petrich BG, Marchese P, Ruggeri ZM, Ginsberg MH, Ruf W. Thrombosis and Inflammation Are Coupled by a Common Thioredoxin Reductase Pathway Downstream of the P2×7 Receptor. Blood. 120: 2218-2218. DOI: 10.1182/Blood.V120.21.2218.2218 |
0.411 |
|
| 2012 |
Lefort CT, Rossaint J, Moser M, Petrich BG, Zarbock A, Monkley SJ, Critchley DR, Ginsberg MH, Fässler R, Ley K. Distinct Roles for Talin-1 and Kindlin-3 in Regulating LFA-1 Conformation during Neutrophil Rolling and Arrest Biophysical Journal. 102: 347a. DOI: 10.1016/J.Bpj.2011.11.1900 |
0.427 |
|
| 2011 |
Ye F, Kim C, Ginsberg MH. Molecular mechanism of inside-out integrin regulation. Journal of Thrombosis and Haemostasis : Jth. 9: 20-5. PMID 21781238 DOI: 10.1111/J.1538-7836.2011.04355.X |
0.436 |
|
| 2011 |
Schmid MC, Avraamides CJ, Dippold HC, Franco I, Foubert P, Ellies LG, Acevedo LM, Manglicmot JR, Song X, Wrasidlo W, Blair SL, Ginsberg MH, Cheresh DA, Hirsch E, Field SJ, et al. Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression. Cancer Cell. 19: 715-27. PMID 21665146 DOI: 10.1016/J.Ccr.2011.04.016 |
0.334 |
|
| 2011 |
Kim C, Ye F, Ginsberg MH. Regulation of integrin activation. Annual Review of Cell and Developmental Biology. 27: 321-45. PMID 21663444 DOI: 10.1146/Annurev-Cellbio-100109-104104 |
0.459 |
|
| 2011 |
Liu JJ, Stockton RA, Gingras AR, Ablooglu AJ, Han J, Bobkov AA, Ginsberg MH. A mechanism of Rap1-induced stabilization of endothelial cell--cell junctions. Molecular Biology of the Cell. 22: 2509-19. PMID 21633110 DOI: 10.1091/Mbc.E11-02-0157 |
0.425 |
|
| 2011 |
Tkachenko E, Sabouri-Ghomi M, Pertz O, Kim C, Gutierrez E, Machacek M, Groisman A, Danuser G, Ginsberg MH. Protein kinase A governs a RhoA-RhoGDI protrusion-retraction pacemaker in migrating cells. Nature Cell Biology. 13: 660-7. PMID 21572420 DOI: 10.1038/Ncb2231 |
0.399 |
|
| 2011 |
Ring C, Ginsberg MH, Haling J, Pendergast AM. Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the alpha4 integrin. Proceedings of the National Academy of Sciences of the United States of America. 108: 149-54. PMID 21173240 DOI: 10.1073/Pnas.1012316108 |
0.764 |
|
| 2011 |
Monkley SJ, Kostourou V, Spence L, Petrich B, Coleman S, Ginsberg MH, Pritchard CA, Critchley DR. Endothelial cell talin1 is essential for embryonic angiogenesis. Developmental Biology. 349: 494-502. PMID 21081121 DOI: 10.1016/J.Ydbio.2010.11.010 |
0.309 |
|
| 2010 |
Garmy-Susini B, Avraamides CJ, Schmid MC, Foubert P, Ellies LG, Barnes L, Feral C, Papayannopoulou T, Lowy A, Blair SL, Cheresh D, Ginsberg M, Varner JA. Integrin alpha4beta1 signaling is required for lymphangiogenesis and tumor metastasis. Cancer Research. 70: 3042-51. PMID 20388801 DOI: 10.1158/0008-5472.Can-09-3761 |
0.303 |
|
| 2010 |
Shattil SJ, Kim C, Ginsberg MH. The final steps of integrin activation: the end game. Nature Reviews. Molecular Cell Biology. 11: 288-300. PMID 20308986 DOI: 10.1038/Nrm2871 |
0.462 |
|
| 2010 |
Stockton RA, Shenkar R, Awad IA, Ginsberg MH. Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity. The Journal of Experimental Medicine. 207: 881-96. PMID 20308363 DOI: 10.1084/Jem.20091258 |
0.347 |
|
| 2010 |
Kummer C, Petrich BG, Rose DM, Ginsberg MH. A small molecule that inhibits the interaction of paxillin and alpha 4 integrin inhibits accumulation of mononuclear leukocytes at a site of inflammation. The Journal of Biological Chemistry. 285: 9462-9. PMID 20097761 DOI: 10.1074/Jbc.M109.066993 |
0.336 |
|
| 2010 |
Ye F, Hu G, Taylor D, Ratnikov B, Bobkov AA, McLean MA, Sligar SG, Taylor KA, Ginsberg MH. Recreation of the terminal events in physiological integrin activation. The Journal of Cell Biology. 188: 157-73. PMID 20048261 DOI: 10.1083/Jcb.200908045 |
0.419 |
|
| 2010 |
Haling JR, Wang F, Ginsberg MH. Phosphoprotein enriched in astrocytes 15 kDa (PEA-15) reprograms growth factor signaling by inhibiting threonine phosphorylation of fibroblast receptor substrate 2alpha. Molecular Biology of the Cell. 21: 664-73. PMID 20032303 DOI: 10.1091/Mbc.E09-08-0659 |
0.764 |
|
| 2010 |
Glading AJ, Ginsberg MH. Rap1 and its effector KRIT1/CCM1 regulate beta-catenin signaling. Disease Models & Mechanisms. 3: 73-83. PMID 20007487 DOI: 10.1242/Dmm.003293 |
0.339 |
|
| 2010 |
Glading AJ, Ginsberg MH. Rap1 and its effector KRIT1/CCM1 regulate -catenin signaling Journal of Cell Science. 123: e1-e1. DOI: 10.1242/Jcs.067728 |
0.326 |
|
| 2009 |
Jones CA, Nishiya N, London NR, Zhu W, Sorensen LK, Chan AC, Lim CJ, Chen H, Zhang Q, Schultz PG, Hayallah AM, Thomas KR, Famulok M, Zhang K, Ginsberg MH, et al. Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity. Nature Cell Biology. 11: 1325-31. PMID 19855388 DOI: 10.1038/Ncb1976 |
0.34 |
|
| 2009 |
Anthis NJ, Haling JR, Oxley CL, Memo M, Wegener KL, Lim CJ, Ginsberg MH, Campbell ID. β integrin tyrosine phosphorylation is a conserved mechanism for regulating talin-induced integrin activation Journal of Biological Chemistry. 284: 36700-36710. PMID 19843520 DOI: 10.1074/Jbc.M109.061275 |
0.787 |
|
| 2009 |
Fogelstrand P, Féral CC, Zargham R, Ginsberg MH. Dependence of proliferative vascular smooth muscle cells on CD98hc (4F2hc, SLC3A2). The Journal of Experimental Medicine. 206: 2397-406. PMID 19841087 DOI: 10.1084/Jem.20082845 |
0.345 |
|
| 2009 |
Anthis NJ, Wegener KL, Ye F, Kim C, Goult BT, Lowe ED, Vakonakis I, Bate N, Critchley DR, Ginsberg MH, Campbell ID. The structure of an integrin/talin complex reveals the basis of inside-out signal transduction Embo Journal. 28: 3623-3632. PMID 19798053 DOI: 10.1038/Emboj.2009.287 |
0.427 |
|
| 2009 |
Huang C, Rajfur Z, Yousefi N, Chen Z, Jacobson K, Ginsberg MH. Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration. Nature Cell Biology. 11: 624-30. PMID 19363486 DOI: 10.1038/Ncb1868 |
0.443 |
|
| 2009 |
Lau TL, Kim C, Ginsberg MH, Ulmer TS. The structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signalling. The Embo Journal. 28: 1351-61. PMID 19279667 DOI: 10.1038/Emboj.2009.63 |
0.378 |
|
| 2009 |
Cantor J, Browne CD, Ruppert R, Féral CC, Fässler R, Rickert RC, Ginsberg MH. CD98hc facilitates B cell proliferation and adaptive humoral immunity. Nature Immunology. 10: 412-9. PMID 19270713 DOI: 10.1038/Ni.1712 |
0.35 |
|
| 2009 |
Kim C, Lau TL, Ulmer TS, Ginsberg MH. Interactions of platelet integrin alphaIIb and beta3 transmembrane domains in mammalian cell membranes and their role in integrin activation. Blood. 113: 4747-53. PMID 19218549 DOI: 10.1182/Blood-2008-10-186551 |
0.412 |
|
| 2009 |
Gingras AR, Ziegler WH, Bobkov AA, Joyce MG, Fasci D, Himmel M, Rothemund S, Ritter A, Grossmann JG, Patel B, Bate N, Goult BT, Emsley J, Barsukov IL, Roberts GC, ... ... Ginsberg MH, et al. Structural determinants of integrin binding to the talin rod. The Journal of Biological Chemistry. 284: 8866-76. PMID 19176533 DOI: 10.1074/Jbc.M805937200 |
0.424 |
|
| 2009 |
Kleaveland B, Zheng X, Liu JJ, Blum Y, Tung JJ, Zou Z, Sweeney SM, Chen M, Guo L, Lu MM, Zhou D, Kitajewski J, Affolter M, Ginsberg MH, Kahn ML. Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway. Nature Medicine. 15: 169-76. PMID 19151727 DOI: 10.1038/Nm.1918 |
0.315 |
|
| 2009 |
Lee HS, Lim CJ, Puzon-McLaughlin W, Shattil SJ, Ginsberg MH. RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences. The Journal of Biological Chemistry. 284: 5119-27. PMID 19098287 DOI: 10.1074/Jbc.M807117200 |
0.394 |
|
| 2009 |
Ablooglu AJ, Kang J, Petrich BG, Ginsberg MH, Shattil SJ. Antithrombotic effects of targeting alphaIIbbeta3 signaling in platelets. Blood. 113: 3585-92. PMID 19005179 DOI: 10.1182/Blood-2008-09-180687 |
0.324 |
|
| 2009 |
Lee J, Hong J, Nam TG, Peters EC, Orth AP, Geierstanger BH, Goldfinger LE, Ginsberg MH, Cho CY, Schultz PG. A small molecule inhibitor of alpha4 integrin-dependent cell migration. Bioorganic & Medicinal Chemistry. 17: 977-80. PMID 18329275 DOI: 10.1016/J.Bmc.2008.02.067 |
0.33 |
|
| 2008 |
Gutierrez E, Petrich BG, Shattil SJ, Ginsberg MH, Groisman A, Kasirer-Friede A. Microfluidic devices for studies of shear-dependent platelet adhesion. Lab On a Chip. 8: 1486-95. PMID 18818803 DOI: 10.1039/B804795B |
0.339 |
|
| 2008 |
Verhaar R, Dekkers DW, De Cuyper IM, Ginsberg MH, de Korte D, Verhoeven AJ. UV-C irradiation disrupts platelet surface disulfide bonds and activates the platelet integrin alphaIIbbeta3. Blood. 112: 4935-9. PMID 18796633 DOI: 10.1182/Blood-2008-04-151043 |
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Lim CJ, Kain KH, Tkachenko E, Goldfinger LE, Gutierrez E, Allen MD, Groisman A, Zhang J, Ginsberg MH. Integrin-mediated protein kinase A activation at the leading edge of migrating cells. Molecular Biology of the Cell. 19: 4930-41. PMID 18784251 DOI: 10.1091/Mbc.E08-06-0564 |
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Cantor JM, Ginsberg MH, Rose DM. Integrin-associated proteins as potential therapeutic targets. Immunological Reviews. 223: 236-51. PMID 18613840 DOI: 10.1111/J.1600-065X.2008.00640.X |
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Goldfinger LE, Tzima E, Stockton R, Kiosses WB, Kinbara K, Tkachenko E, Gutierrez E, Groisman A, Nguyen P, Chien S, Ginsberg MH. Localized alpha4 integrin phosphorylation directs shear stress-induced endothelial cell alignment. Circulation Research. 103: 177-85. PMID 18583710 DOI: 10.1161/Circresaha.108.176354 |
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Watanabe N, Bodin L, Pandey M, Krause M, Coughlin S, Boussiotis VA, Ginsberg MH, Shattil SJ. Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3. The Journal of Cell Biology. 181: 1211-22. PMID 18573917 DOI: 10.1083/Jcb.200803094 |
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Helsten TL, Bunch TA, Kato H, Yamanouchi J, Choi SH, Jannuzi AL, Féral CC, Ginsberg MH, Brower DL, Shattil SJ. Differences in regulation of Drosophila and vertebrate integrin affinity by talin. Molecular Biology of the Cell. 19: 3589-98. PMID 18508915 DOI: 10.1091/Mbc.E08-01-0085 |
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Banno A, Ginsberg MH. Integrin activation. Biochemical Society Transactions. 36: 229-34. PMID 18363565 DOI: 10.1042/BST0360229 |
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Lau TL, Partridge AW, Ginsberg MH, Ulmer TS. Structure of the integrin beta3 transmembrane segment in phospholipid bicelles and detergent micelles. Biochemistry. 47: 4008-16. PMID 18321071 DOI: 10.1021/Bi800107A |
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Ablooglu AJ, Kang J, Petrich BG, Ginsberg MH, Shattil SJ. Anti-Thrombotic Effects of Targeting Outside-in αIIbβ3 Signaling in Platelets Blood. 112: 411-411. DOI: 10.1182/Blood.V112.11.411.411 |
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Banno A, Ginsberg MH. The Ins and Outs of Integrin Signaling Cell Junctions: Adhesion, Development, and Disease. 1-23. DOI: 10.1002/9783527622092.ch1 |
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Petrich BG, Marchese P, Ruggeri ZM, Spiess S, Weichert RA, Ye F, Tiedt R, Skoda RC, Monkley SJ, Critchley DR, Ginsberg MH. Talin is required for integrin-mediated platelet function in hemostasis and thrombosis. The Journal of Experimental Medicine. 204: 3103-11. PMID 18086863 DOI: 10.1084/Jem.20071800 |
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Glading A, Han J, Stockton RA, Ginsberg MH. KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions. The Journal of Cell Biology. 179: 247-54. PMID 17954608 DOI: 10.1083/Jcb.200705175 |
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Féral CC, Zijlstra A, Tkachenko E, Prager G, Gardel ML, Slepak M, Ginsberg MH. CD98hc (SLC3A2) participates in fibronectin matrix assembly by mediating integrin signaling. The Journal of Cell Biology. 178: 701-11. PMID 17682053 DOI: 10.1083/Jcb.200705090 |
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Petrich BG, Fogelstrand P, Partridge AW, Yousefi N, Ablooglu AJ, Shattil SJ, Ginsberg MH. The antithrombotic potential of selective blockade of talin-dependent integrin alpha IIb beta 3 (platelet GPIIb-IIIa) activation. The Journal of Clinical Investigation. 117: 2250-9. PMID 17627302 DOI: 10.1172/Jci31024 |
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Rose DM, Alon R, Ginsberg MH. Integrin modulation and signaling in leukocyte adhesion and migration. Immunological Reviews. 218: 126-34. PMID 17624949 DOI: 10.1111/J.1600-065X.2007.00536.X |
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Vogelezang M, Forster UB, Han J, Ginsberg MH, ffrench-Constant C. Neurite outgrowth on a fibronectin isoform expressed during peripheral nerve regeneration is mediated by the interaction of paxillin with alpha4beta1 integrins. Bmc Neuroscience. 8: 44. PMID 17603879 DOI: 10.1186/1471-2202-8-44 |
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Prager GW, Féral CC, Kim C, Han J, Ginsberg MH. CD98hc (SLC3A2) interaction with the integrin beta subunit cytoplasmic domain mediates adhesive signaling. The Journal of Biological Chemistry. 282: 24477-84. PMID 17597067 DOI: 10.1074/Jbc.M702877200 |
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Zhang Q, Major MB, Takanashi S, Camp ND, Nishiya N, Peters EC, Ginsberg MH, Jian X, Randazzo PA, Schultz PG, Moon RT, Ding S. Small-molecule synergist of the Wnt/beta-catenin signaling pathway. Proceedings of the National Academy of Sciences of the United States of America. 104: 7444-8. PMID 17460038 DOI: 10.1073/Pnas.0702136104 |
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Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Han J, Haling JR, Sherman NE, Fox JW, Hunt DF, Ginsberg MH. An experimentally derived database of candidate Ras-interacting proteins. Journal of Proteome Research. 6: 1806-11. PMID 17439166 DOI: 10.1021/Pr060630L |
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Lim CJ, Han J, Yousefi N, Ma Y, Amieux PS, McKnight GS, Taylor SS, Ginsberg MH. Alpha4 integrins are type I cAMP-dependent protein kinase-anchoring proteins. Nature Cell Biology. 9: 415-21. PMID 17369818 DOI: 10.1038/Ncb1561 |
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Zou W, Kitaura H, Reeve J, Long F, Tybulewicz VL, Shattil SJ, Ginsberg MH, Ross FP, Teitelbaum SL. Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption. The Journal of Cell Biology. 176: 877-88. PMID 17353363 DOI: 10.1083/Jcb.200611083 |
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Glading A, Koziol JA, Krueger J, Ginsberg MH. PEA-15 inhibits tumor cell invasion by binding to extracellular signal-regulated kinase 1/2. Cancer Research. 67: 1536-44. PMID 17308092 DOI: 10.1158/0008-5472.Can-06-1378 |
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Wegener KL, Partridge AW, Han J, Pickford AR, Liddington RC, Ginsberg MH, Campbell ID. Structural basis of integrin activation by talin. Cell. 128: 171-82. PMID 17218263 DOI: 10.1016/J.Cell.2006.10.048 |
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Kasirer-Friede A, Gutierrez E, Petrich B, Shattil SJ, Ginsberg MH, Groisman A. Just a Drop of Blood: Exploration of Shear-Dependent Platelet Adhesion and Activation in Microfluidic Devices. Blood. 110: 3650-3650. DOI: 10.1182/Blood.V110.11.3650.3650 |
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Han J, Lim CJ, Watanabe N, Soriani A, Ratnikov B, Calderwood DA, Puzon-McLaughlin W, Lafuente EM, Boussiotis VA, Shattil SJ, Ginsberg MH. Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3. Current Biology : Cb. 16: 1796-806. PMID 16979556 DOI: 10.1016/J.Cub.2006.08.035 |
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Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH. RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration. The Journal of Cell Biology. 174: 877-88. PMID 16966426 DOI: 10.1083/Jcb.200603111 |
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Orr AW, Ginsberg MH, Shattil SJ, Deckmyn H, Schwartz MA. Matrix-specific suppression of integrin activation in shear stress signaling. Molecular Biology of the Cell. 17: 4686-97. PMID 16928957 DOI: 10.1091/Mbc.E06-04-0289 |
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Lad Y, McHugh B, Hodkinson PS, Mackinnon AC, Haslett C, Ginsberg MH, Sethi T. Phospholipase C epsilon suppresses integrin activation. The Journal of Biological Chemistry. 281: 29501-12. PMID 16895916 DOI: 10.1074/Jbc.M513471200 |
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Kummer C, Ginsberg MH. New approaches to blockade of alpha4-integrins, proven therapeutic targets in chronic inflammation. Biochemical Pharmacology. 72: 1460-8. PMID 16870156 DOI: 10.1016/J.Bcp.2006.06.014 |
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Bartholomeusz C, Itamochi H, Nitta M, Saya H, Ginsberg MH, Ueno NT. Antitumor effect of E1A in ovarian cancer by cytoplasmic sequestration of activated ERK by PEA15. Oncogene. 25: 79-90. PMID 16170361 DOI: 10.1038/Sj.Onc.1209014 |
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Watanabe N, Han J, Lim CJ, Soriani A, Puzon-McLaughlin W, LaFuente EM, Boussiotis VA, Ginsberg MH, Shattil SJ. On the Yellow Brick Road to Platelet GP IIb-IIIa (Integrin αIIbβ3) Activation. Blood. 108: 211-211. DOI: 10.1182/Blood.V108.11.211.211 |
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Alon R, Feigelson SW, Manevich E, Rose DM, Schmitz J, Overby DR, Winter E, Grabovsky V, Shinder V, Matthews BD, Sokolovsky-Eisenberg M, Ingber DE, Benoit M, Ginsberg MH. Alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domain. The Journal of Cell Biology. 171: 1073-84. PMID 16365170 DOI: 10.1083/Jcb.200503155 |
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Hsia DA, Lim ST, Bernard-Trifilo JA, Mitra SK, Tanaka S, den Hertog J, Streblow DN, Ilic D, Ginsberg MH, Schlaepfer DD. Integrin alpha4beta1 promotes focal adhesion kinase-independent cell motility via alpha4 cytoplasmic domain-specific activation of c-Src. Molecular and Cellular Biology. 25: 9700-12. PMID 16227616 DOI: 10.1128/Mcb.25.21.9700-9712.2005 |
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Ratnikov BI, Partridge AW, Ginsberg MH. Integrin activation by talin Journal of Thrombosis and Haemostasis. 3: 1783-1790. PMID 16102045 DOI: 10.1111/J.1538-7836.2005.01362.X |
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Arias-Salgado EG, Lizano S, Shattil SJ, Ginsberg MH. Specification of the direction of adhesive signaling by the integrin beta cytoplasmic domain. The Journal of Biological Chemistry. 280: 29699-707. PMID 15937333 DOI: 10.1074/Jbc.M503508200 |
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Krueger J, Chou FL, Glading A, Schaefer E, Ginsberg MH. Phosphorylation of phosphoprotein enriched in astrocytes (PEA-15) regulates extracellular signal-regulated kinase-dependent transcription and cell proliferation. Molecular Biology of the Cell. 16: 3552-61. PMID 15917297 DOI: 10.1091/Mbc.E04-11-1007 |
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Nishiya N, Kiosses WB, Han J, Ginsberg MH. An alpha4 integrin-paxillin-Arf-GAP complex restricts Rac activation to the leading edge of migrating cells. Nature Cell Biology. 7: 343-52. PMID 15793570 DOI: 10.1038/Ncb1234 |
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Feral CC, Nishiya N, Fenczik CA, Stuhlmann H, Slepak M, Ginsberg MH. CD98hc (SLC3A2) mediates integrin signaling. Proceedings of the National Academy of Sciences of the United States of America. 102: 355-60. PMID 15625115 DOI: 10.1073/Pnas.0404852102 |
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de Pereda JM, Wegener KL, Santelli E, Bate N, Ginsberg MH, Critchley DR, Campbell ID, Liddington RC. Structural basis for phosphatidylinositol phosphate kinase type Igamma binding to talin at focal adhesions. The Journal of Biological Chemistry. 280: 8381-6. PMID 15623515 DOI: 10.1074/Jbc.M413180200 |
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Henderson NC, Collis EA, Mackinnon AC, Simpson KJ, Haslett C, Zent R, Ginsberg M, Sethi T. CD98hc (SLC3A2) interaction with beta 1 integrins is required for transformation. Journal of Biological Chemistry. 279: 54731-54741. PMID 15485886 DOI: 10.1074/Jbc.M408700200 |
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Campbell ID, Ginsberg MH. The talin-tail interaction places integrin activation on FERM ground. Trends in Biochemical Sciences. 29: 429-35. PMID 15362227 DOI: 10.1016/J.Tibs.2004.06.005 |
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Calderwood DA, Tai V, Di Paolo G, De Camilli P, Ginsberg MH. Competition for talin results in trans-dominant inhibition of integrin activation. The Journal of Biological Chemistry. 279: 28889-95. PMID 15143061 DOI: 10.1074/Jbc.M402161200 |
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Kloeker S, Major MB, Calderwood DA, Ginsberg MH, Jones DA, Beckerle MC. The Kindler syndrome protein is regulated by transforming growth factor-beta and involved in integrin-mediated adhesion. The Journal of Biological Chemistry. 279: 6824-33. PMID 14634021 DOI: 10.1074/Jbc.M307978200 |
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Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR. Cell migration: integrating signals from front to back. Science (New York, N.Y.). 302: 1704-9. PMID 14657486 DOI: 10.1126/Science.1092053 |
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Arias-Salgado EG, Lizano S, Sarkar S, Brugge JS, Ginsberg MH, Shattil SJ. Src kinase activation by direct interaction with the integrin beta cytoplasmic domain. Proceedings of the National Academy of Sciences of the United States of America. 100: 13298-302. PMID 14593208 DOI: 10.1073/Pnas.2336149100 |
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Kinbara K, Goldfinger LE, Hansen M, Chou FL, Ginsberg MH. Ras GTPases: Integrins' friends or foes? Nature Reviews Molecular Cell Biology. 4: 767-776. PMID 14570053 DOI: 10.1038/Nrm1229 |
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Tadokoro S, Shattil SJ, Eto K, Tai V, Liddington RC, de Pereda JM, Ginsberg MH, Calderwood DA. Talin binding to integrin beta tails: a final common step in integrin activation. Science (New York, N.Y.). 302: 103-6. PMID 14526080 DOI: 10.1126/Science.1086652 |
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Chou FL, Hill JM, Hsieh JC, Pouyssegur J, Brunet A, Glading A, Uberall F, Ramos JW, Werner MH, Ginsberg MH. PEA-15 binding to ERK1/2 MAPKs is required for its modulation of integrin activation. The Journal of Biological Chemistry. 278: 52587-97. PMID 14506247 DOI: 10.1074/Jbc.M309322200 |
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Goldfinger LE, Han J, Kiosses WB, Howe AK, Ginsberg MH. Spatial restriction of alpha4 integrin phosphorylation regulates lamellipodial stability and alpha4beta1-dependent cell migration. The Journal of Cell Biology. 162: 731-41. PMID 12913113 DOI: 10.1083/Jcb.200304031 |
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Calderwood DA, Ginsberg MH. Talin forges the links between integrins and actin. Nature Cell Biology. 5: 694-7. PMID 12894175 DOI: 10.1038/Ncb0803-694 |
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Ulmer TS, Calderwood DA, Ginsberg MH, Campbell ID. Domain-specific interactions of talin with the membrane-proximal region of the integrin beta3 subunit. Biochemistry. 42: 8307-12. PMID 12846579 DOI: 10.1021/Bi034384S |
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Han J, Rose DM, Woodside DG, Goldfinger LE, Ginsberg MH. Integrin α4β1-dependent T cell migration requires both phosphorylation and dephosphorylation of the α4 cytoplasmic domain to regulate the reversible binding of paxillin Journal of Biological Chemistry. 278: 34845-34853. PMID 12837751 DOI: 10.1074/Jbc.M304691200 |
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Rose DM, Liu S, Woodside DG, Han J, Schlaepfer DD, Ginsberg MH. Paxillin binding to the alpha 4 integrin subunit stimulates LFA-1 (integrin alpha L beta 2)-dependent T cell migration by augmenting the activation of focal adhesion kinase/proline-rich tyrosine kinase-2. Journal of Immunology (Baltimore, Md. : 1950). 170: 5912-8. PMID 12794117 DOI: 10.4049/Jimmunol.170.12.5912 |
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García-Alvarez B, de Pereda JM, Calderwood DA, Ulmer TS, Critchley D, Campbell ID, Ginsberg MH, Liddington RC. Structural determinants of integrin recognition by talin. Molecular Cell. 11: 49-58. PMID 12535520 DOI: 10.1016/S1097-2765(02)00823-7 |
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Hughes PE, Oertli B, Hansen M, Chou FL, Willumsen BM, Ginsberg MH. Suppression of integrin activation by activated Ras or Raf does not correlate with bulk activation of ERK MAP kinase. Molecular Biology of the Cell. 13: 2256-65. PMID 12134066 DOI: 10.1091/Mbc.01-10-0480 |
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Hill JM, Vaidyanathan H, Ramos JW, Ginsberg MH, Werner MH. Recognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domain. The Embo Journal. 21: 6494-504. PMID 12456656 DOI: 10.1093/Emboj/Cdf641 |
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Ambroise Y, Yaspan B, Ginsberg MH, Boger DL. Inhibitors of cell migration that inhibit intracellular Paxillin/α4 binding: A well-documented use of positional scanning libraries Chemistry and Biology. 9: 1219-1226. PMID 12445772 DOI: 10.1016/S1074-5521(02)00246-6 |
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Riederer MA, Ginsberg MH, Steiner B. Blockade of platelet GPIIB-IIIA (integrin αIIbβ3) in flowing human blood leads to passivation of prothrombotic surfaces Thrombosis and Haemostasis. 88: 858-864. PMID 12428106 DOI: 10.1055/S-0037-1613314 |
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Rose DM, Han J, Ginsberg MH. α4 integrins and the immune response Immunological Reviews. 186: 118-124. PMID 12234367 DOI: 10.1034/J.1600-065X.2002.18611.X |
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Liddington RC, Ginsberg MH. Integrin activation takes shape Journal of Cell Biology. 158: 833-839. PMID 12213832 DOI: 10.1083/Jcb.200206011 |
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Woodside DG, Obergfell A, Talapatra A, Calderwood DA, Shattil SJ, Ginsberg MH. The N-terminal SH2 domains of Syk and ZAP-70 mediate phosphotyrosine-independent binding to integrin beta cytoplasmic domains. The Journal of Biological Chemistry. 277: 39401-8. PMID 12171941 DOI: 10.1074/Jbc.M207657200 |
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Ramos JW, Ginsberg M. Expression cloning strategies for the identification of adhesion molecules. Methods in Cell Biology. 69: 209-21. PMID 12070994 DOI: 10.1016/S0091-679X(02)69014-4 |
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Schwartz MA, Ginsberg MH. Networks and crosstalk: integrin signalling spreads. Nature Cell Biology. 4: E65-8. PMID 11944032 DOI: 10.1038/Ncb0402-E65 |
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Calderwood DA, Yan B, de Pereda JM, Alvarez BG, Fujioka Y, Liddington RC, Ginsberg MH. The phosphotyrosine binding-like domain of talin activates integrins. The Journal of Biological Chemistry. 277: 21749-58. PMID 11932255 DOI: 10.1074/Jbc.M111996200 |
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Liu S, Kiosses WB, Rose DM, Slepak M, Salgia R, Griffin JD, Turner CE, Schwartz MA, Ginsberg MH. A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and selectively inhibits alpha 4-mediated cell migration. The Journal of Biological Chemistry. 277: 20887-94. PMID 11919182 DOI: 10.1074/Jbc.M110928200 |
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Calderwood DA, Huttenlocher A, Kiosses WB, Rose DM, Woodside DG, Schwartz MA, Ginsberg MH. Increased filamin binding to β-integrin cytoplasmic domains inhibits cell migration Nature Cell Biology. 3: 1060-1068. PMID 11781567 DOI: 10.1038/Ncb1201-1060 |
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Woodside DG, Obergfell A, Leng L, Wilsbacher JL, Miranti CK, Brugge JS, Shattil SJ, Ginsberg MH. Activation of Syk protein tyrosine kinase through interaction with integrin β cytoplasmic domains Current Biology. 11: 1799-1804. PMID 11719224 DOI: 10.1016/S0960-9822(01)00565-6 |
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Formstecher E, Ramos JW, Fauquet M, Calderwood DA, Hsieh JC, Canton B, Nguyen XT, Barnier JV, Camonis J, Ginsberg MH, Chneiweiss H. PEA-15 Mediates Cytoplasmic Sequestration of ERK MAP Kinase Developmental Cell. 1: 239-250. PMID 11702783 DOI: 10.1016/S1534-5807(01)00035-1 |
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Matter ML, Ginsberg MH, Ramos JW. Identification of cell signaling molecules by expression cloning Science's Stke : Signal Transduction Knowledge Environment. 2001. PMID 11593050 DOI: 10.1126/Stke.2001.103.Pl9 |
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Woodside DG, Shattil SJ, Ginsberg MH. The T cell receptor SLAPs integrins together Nature Immunology. 2: 904-905. PMID 11577344 DOI: 10.1038/Ni1001-904 |
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Han J, Liu S, Rose DM, Schlaepfer DD, McDonald H, Ginsberg MH. Phosphorylation of the integrin alpha 4 cytoplasmic domain regulates paxillin binding. The Journal of Biological Chemistry. 276: 40903-9. PMID 11533025 DOI: 10.1074/Jbc.M102665200 |
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Rose DM, Grabovsky V, Alon R, Ginsberg MH. The affinity of integrin α4β1 governs lymphocyte migration Journal of Immunology. 167: 2824-2830. PMID 11509628 DOI: 10.4049/Jimmunol.167.5.2824 |
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Liu S, Slepak M, Ginsberg MH. Binding of Paxillin to the α9 Integrin Cytoplasmic Domain Inhibits Cell Spreading Journal of Biological Chemistry. 276: 37086-37092. PMID 11477105 DOI: 10.1074/Jbc.M105114200 |
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Ulmer TS, Yaspan B, Ginsberg MH, Campbell ID. NMR analysis of structure and dynamics of the cytosolic tails of integrin αIIβ3 in aqueous solution Biochemistry. 40: 7498-7508. PMID 11412103 DOI: 10.1021/Bi010338L |
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Hughes PE, Oertli B, Han J, Ginsberg MH. R-Ras regulation of integrin function Methods in Enzymology. 333: 163-171. PMID 11400334 DOI: 10.1016/S0076-6879(01)33054-9 |
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Yan B, Calderwood DA, Yaspan B, Ginsberg MH. Calpain Cleavage Promotes Talin Binding to the β3 Integrin Cytoplasmic Domain Journal of Biological Chemistry. 276: 28164-28170. PMID 11382782 DOI: 10.1074/Jbc.M104161200 |
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Felding-Habermann B, O'Toole TE, Smith JW, Fransvea E, Ruggeri ZM, Ginsberg MH, Hughes PE, Pampori N, Shattil SJ, Saven A, Mueller BM. Integrin activation controls metastasis in human breast cancer Proceedings of the National Academy of Sciences of the United States of America. 98: 1853-1858. PMID 11172040 DOI: 10.1073/Pnas.98.4.1853 |
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Alugupalli KR, Michelson AD, Barnard MR, Robbins D, Coburn J, Baker EK, Ginsberg MH, Schwan TG, Leong JM. Platelet activation by a relapsing fever spirochaete results in enhanced bacterium-platelet interaction via integrin alphaIIbbeta3 activation. Molecular Microbiology. 39: 330-40. PMID 11136454 DOI: 10.1046/J.1365-2958.2001.02201.X |
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Berrier AL, Mastrangelo AM, Downward J, Ginsberg M, LaFlamme SE. Activated R-ras, Rac1, PI 3-kinase and PKCepsilon can each restore cell spreading inhibited by isolated integrin beta1 cytoplasmic domains. The Journal of Cell Biology. 151: 1549-60. PMID 11134082 DOI: 10.1083/Jcb.151.7.1549 |
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Fenczik CA, Zent R, Dellos M, Calderwood DA, Satriano J, Kelly C, Ginsberg MH. Distinct Domains of CD98hc Regulate Integrins and Amino Acid Transport Journal of Biological Chemistry. 276: 8746-8752. PMID 11121428 DOI: 10.1074/Jbc.M011239200 |
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Liu S, Rose DM, Han J, Ginsberg MH. α4 integrins in cardiovascular development and diseases Trends in Cardiovascular Medicine. 10: 253-257. PMID 11282303 DOI: 10.1016/S1050-1738(00)00073-6 |
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Oertli B, Han J, Marte BM, Sethi T, Downward J, Ginsberg M, Hughes PE. The effector loop and prenylation site of R-Ras are involved in the regulation of integrin function Oncogene. 19: 4961-4969. PMID 11042683 DOI: 10.1038/Sj.Onc.1203876 |
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Liu S, Calderwood DA, Ginsberg MH. Integrin cytoplasmic domain-binding proteins Journal of Cell Science. 113: 3563-3571. PMID 11017872 |
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Ramos JW, Hughes PE, Renshaw MW, Schwartz MA, Formstecher E, Chneiweiss H, Ginsberg MH. Death effector domain protein PEA-15 potentiates Ras activation of extracellular signal receptor-activated kinase by an adhesion-independent mechanism. Molecular Biology of the Cell. 11: 2863-72. PMID 10982386 DOI: 10.1091/Mbc.11.9.2863 |
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Calderwood DA, Shattil SJ, Ginsberg MH. Integrins and actin filaments: Reciprocal regulation of cell adhesion and signaling Journal of Biological Chemistry. 275: 22607-22610. PMID 10801899 DOI: 10.1074/Jbc.R900037199 |
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Liu S, Ginsberg MH. Paxillin binding to a conserved sequence motif in the α4 integrin cytoplasmic domain Journal of Biological Chemistry. 275: 22736-22742. PMID 10781578 DOI: 10.1074/Jbc.M000388200 |
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Zent R, Fenczik CA, Calderwood DA, Liu S, Dellos M, Ginsberg MH. Class- and splice variant-specific association of CD98 with integrin β cytoplasmic domains Journal of Biological Chemistry. 275: 5059-5064. PMID 10671548 DOI: 10.1074/Jbc.275.7.5059 |
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Rose DM, Cardarelli PM, Cobb RR, Ginsberg MH. Soluble VCAM-1 binding to α4 integrins is cell-type specific and activation dependent and is disrupted during apoptosis in T cells Blood. 95: 602-609. PMID 10627469 DOI: 10.1182/Blood.V95.2.602 |
0.446 |
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| 2000 |
Liu S, Thomas SM, Woodside DG, Rose DM, Kiosses WB, Pfaff M, Ginsberg MH. Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses. Nature. 402: 676-81. PMID 10604475 DOI: 10.1038/45264 |
0.352 |
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| 1999 |
Pfaff M, Du X, Ginsberg MH. Calpain cleavage of integrin β cytoplasmic domains Febs Letters. 460: 17-22. PMID 10571053 DOI: 10.1016/S0014-5793(99)01250-8 |
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| 1999 |
Savage B, Ginsberg MH, Ruggeri ZM. Influence of fibrillar collagen structure on the mechanisms of platelet thrombus formation under flow Blood. 94: 2704-2715. PMID 10515874 DOI: 10.1182/Blood.V94.8.2704.420K41_2704_2715 |
0.358 |
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Calderwood DA, Zent R, Grant R, Rees DJG, Hynes RO, Ginsberg MH. The talin head domain binds to integrin β subunit cytoplasmic tails and regulates integrin activation Journal of Biological Chemistry. 274: 28071-28074. PMID 10497155 DOI: 10.1074/Jbc.274.40.28071 |
0.42 |
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| 1999 |
Shimizu Y, Rose DM, Ginsberg MH. Integrins in the immune system Advances in Immunology. 72: 325-380. PMID 10361579 DOI: 10.1016/S0065-2776(08)60024-3 |
0.36 |
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| 1999 |
Sethi T, Ginsberg MH, Downward J, Hughes PE. The small GTP-binding protein R-Ras can influence integrin activation by antagonizing a Ras/Raf-initiated integrin suppression pathway Molecular Biology of the Cell. 10: 1799-1809. PMID 10359597 DOI: 10.1091/Mbc.10.6.1799 |
0.34 |
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| 1999 |
Gavrilovskaya IN, Brown EJ, Ginsberg MH, Mackow ER. Cellular entry of hantaviruses which cause hemorrhagic fever with renal syndrome is mediated by β3 integrins Journal of Virology. 73: 3951-3959. PMID 10196290 DOI: 10.1128/Jvi.73.5.3951-3959.1999 |
0.357 |
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| 1999 |
Tozer EC, Baker EK, Ginsberg MH, Loftus JC. A mutation in the α subunit of the platelet integrin α(IIb)β3 identifies a novel region important for ligand binding Blood. 93: 918-924. PMID 9920841 DOI: 10.1182/Blood.V93.3.918 |
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| 1999 |
Law DA, Nannizzi-Alaimo L, Ministri K, Hughes PE, Forsyth J, Turner M, Shattil SJ, Ginsberg MH, Tybulewicz VL, Phillips DR. Genetic and Pharmacological Analyses of Syk Function in IIbβ3 Signaling in Platelets Blood. 93: 2645-2652. DOI: 10.1182/Blood.V93.8.2645 |
0.394 |
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| 1999 |
Du X, Ginsberg MH. Signaling and Platelet Adhesion Advances in Molecular and Cell Biology. 28: 269-301. DOI: 10.1016/S1569-2558(08)60050-8 |
0.376 |
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| 1998 |
Ramos JW, Kojima TK, Hughes PE, Fenczik CA, Ginsberg MH. The death effector domain of PEA-15 is involved in its regulation of integrin activation Journal of Biological Chemistry. 273: 33897-33900. PMID 9852038 DOI: 10.1074/Jbc.273.51.33897 |
0.695 |
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| 1998 |
Ross RS, Pham C, Shai SY, Goldhaber JI, Fenczik C, Glembotski CC, Ginsberg MH, Loftus JC. Beta1 integrins participate in the hypertrophic response of rat ventricular myocytes. Circulation Research. 82: 1160-72. PMID 9633916 DOI: 10.1161/01.Res.82.11.1160 |
0.372 |
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| 1998 |
Gavrilovskaya IN, Shepley M, Shaw R, Ginsberg MH, Mackow ER. β3 integrins mediate the cellular entry of hantaviruses that cause respiratory failure Proceedings of the National Academy of Sciences of the United States of America. 95: 7074-7079. PMID 9618541 DOI: 10.1073/Pnas.95.12.7074 |
0.342 |
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| 1998 |
Jenkins AL, Nannizzi-Alaimo L, Silver D, Sellers JR, Ginsberg MH, Law DA, Phillips DR. Tyrosine phosphorylation of the beta3 cytoplasmic domain mediates integrin-cytoskeletal interactions. The Journal of Biological Chemistry. 273: 13878-85. PMID 9593734 DOI: 10.1074/Jbc.273.22.13878 |
0.367 |
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Pfaff M, Liu S, Erle DJ, Ginsberg MH. Integrin β cytoplasmic domains differentially bind to cytoskeletal proteins Journal of Biological Chemistry. 273: 6104-6109. PMID 9497328 DOI: 10.1074/Jbc.273.11.6104 |
0.419 |
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| 1997 |
Huttenlocher A, Palecek SP, Lu Q, Zhang W, Mellgren RL, Lauffenburger DA, Ginsberg MH, Horwitz AF. Regulation of cell migration by the calcium-dependent protease calpain Journal of Biological Chemistry. 272: 32719-32722. PMID 9407041 DOI: 10.1074/Jbc.272.52.32719 |
0.393 |
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Felding-Habermann B, Silletti S, Mei F, Siu CH, Yip PM, Brooks PC, Cheresh DA, O'Toole TE, Ginsberg MH, Montgomery AM. A single immunoglobulin-like domain of the human neural cell adhesion molecule L1 supports adhesion by multiple vascular and platelet integrins. The Journal of Cell Biology. 139: 1567-81. PMID 9396761 DOI: 10.1083/Jcb.139.6.1567 |
0.359 |
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Fenczik CA, Sethi T, Ramos JW, Hughes PE, Ginsberg MH. Complementation of dominant suppression implicates CD98 in integrin activation Nature. 390: 81-85. PMID 9363894 DOI: 10.1038/36349 |
0.713 |
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| 1997 |
Indig FE, Diaz-Gonzalez F, Ginsberg MH. Analysis of the tetraspanin CD9-integrin α(IIb)β3 (GPIIb-IIIa) complex in platelet membranes and transfected cells Biochemical Journal. 327: 291-298. PMID 9355765 DOI: 10.1042/Bj3270291 |
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Gao J, Zoller KE, Ginsberg MH, Brugge JS, Shattil SJ. Regulation of the pp72(syk) protein tyrosine kinase by platelet integrin α(IIb)β3 Embo Journal. 16: 6414-6425. PMID 9351824 DOI: 10.1093/Emboj/16.21.6414 |
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Shattil SJ, Ginsberg MH. Perspectives series: cell adhesion in vascular biology. Integrin signaling in vascular biology The Journal of Clinical Investigation. 100: 1-5. PMID 9202049 DOI: 10.1172/Jci119500 |
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Kashiwagi H, Schwartz MA, Eigenthaler M, Davis KA, Ginsberg MH, Shattil SJ. Affinity modulation of platelet integrin alphaIIbbeta3 by beta3-endonexin, a selective binding partner of the beta3 integrin cytoplasmic tail. The Journal of Cell Biology. 137: 1433-43. PMID 9182673 DOI: 10.1083/Jcb.137.6.1433 |
0.426 |
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Eigenthaler M, Höfferer L, Shattil SJ, Ginsberg MH. A conserved sequence motif in the integrin β3 cytoplasmic domain is required for its specific interaction with β3-endonexin Journal of Biological Chemistry. 272: 7693-7698. PMID 9065427 DOI: 10.1074/Jbc.272.12.7693 |
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Hughes PE, Renshaw MW, Pfaff M, Forsyth J, Keivens VM, Schwartz MA, Ginsberg MH. Suppression of integrin activation: a novel function of a Ras/Raf-initiated MAP kinase pathway. Cell. 88: 521-30. PMID 9038343 DOI: 10.1016/S0092-8674(00)81892-9 |
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Palecek SP, Loftust JC, Ginsberg MH, Lauffenburger DA, Horwitz AF. Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness Nature. 385: 537-540. PMID 9020360 DOI: 10.1038/385537A0 |
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Ginsberg MH, Baker EK, Tozer BC, Shaltil SJ, Loflus JC. A genetic analysis of 1ntegrin function: glanzmann thrombasthenia in vitro Faseb Journal. 11. DOI: 10.1073/Pnas.94.5.1973 |
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Du X, Ginsberg MH. Integrin αIIbβ3 and Platelet Function Thrombosis and Haemostasis. 78: 096-100. DOI: 10.1055/S-0038-1657508 |
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Palecek SP, Loftus JC, Ginsberg MH, Lauffenburger DA, Horwitz AF. Erratum: Integrin–ligand binding properties govern cell migration speed through cell–substratum adhesiveness Nature. 388: 210-210. DOI: 10.1038/40687 |
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Díaz-González F, Forsyth J, Steiner B, Ginsberg MH. Trans-dominant inhibition of integrin function Molecular Biology of the Cell. 7: 1939-1951. PMID 8970156 DOI: 10.1091/Mbc.7.12.1939 |
0.418 |
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| 1996 |
Wu C, Hughes PE, Ginsberg MH, Mcdonald JA. Identification of a new biological function for the integrin αvβ3: Initiation of fibronectin matrix assembly Cell Communication and Adhesion. 4: 149-158. PMID 8969861 DOI: 10.3109/15419069609014219 |
0.37 |
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| 1996 |
Ginsberg MH, Ruggeri ZM, Varki AP. Cell adhesion in vascular biology: series introductin The Journal of Clinical Investigation. 98: 1505. PMID 8833895 DOI: 10.1172/Jci118939 |
0.309 |
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Huttenlocher A, Ginsberg MH, Horwitz AF. Modulation of cell migration by integrin-mediated cytoskeletal linkages and ligand-binding affinity Journal of Cell Biology. 134: 1551-1562. PMID 8830782 DOI: 10.1083/Jcb.134.6.1551 |
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Hughes PE, Diaz-Gonzalez F, Leong L, Wu C, McDonald JA, Shattil SJ, Ginsberg MH. Breaking the integrin hinge. A defined structural constraint regulates integrin signaling. The Journal of Biological Chemistry. 271: 6571-4. PMID 8636068 DOI: 10.1074/Jbc.271.12.6571 |
0.394 |
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Leong L, Hughes PE, Schwartz MA, Ginsberg MH, Shattil SJ. Integrin signaling: Roles for the cytoplasmic tails of αIIbβ3 in the tyrosine phosphorylation of pp125FAK Journal of Cell Science. 108: 3817-3825. PMID 8719888 |
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Schwartz MA, Schaller MD, Ginsberg MH. Integrins: Emerging paradigms of signal transduction Annual Review of Cell and Developmental Biology. 11: 549-599. PMID 8689569 DOI: 10.1146/Annurev.Cb.11.110195.003001 |
0.405 |
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Ginsberg MH. Integrins: Dynamic regulation of ligand binding Biochemical Society Transactions. 23: 439-446. PMID 8566327 DOI: 10.1042/Bst0230439 |
0.328 |
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Williams MJ, Du X, Loftus JC, Ginsberg MH. Platelet adhesion receptors Seminars in Cell and Developmental Biology. 6: 305-314. PMID 8562923 DOI: 10.1006/Scel.1995.0040 |
0.381 |
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Wu C, Keivenst VM, O'Toole TE, McDonald JA, Ginsberg MH. Integrin activation and cytoskeletal interaction are essential for the assembly of a fibronectin matrix Cell. 83: 715-724. PMID 8521488 DOI: 10.1016/0092-8674(95)90184-1 |
0.401 |
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| 1995 |
Sanfilippo PJ, Urbanski MJ, Beers KN, Eckardt A, Falotico R, Ginsberg MH, Offord S, Press JB, Tighe J, Tomko K, Andrade-Gordon P. Novel thiazole-based heterocycles as selective inhibitors of fibrinogen-mediated platelet aggregation Journal of Medicinal Chemistry. 38: 34-41. PMID 7837237 DOI: 10.1021/Jm00001A008 |
0.344 |
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| 1995 |
Hughes PE, O'Toole TE, Ylanne J, Shattil SJ, Ginsberg MH. The conserved membrane-proximal region of an integrin cytoplasmic domain specifies ligand binding affinity Journal of Biological Chemistry. 270: 12411-12417. PMID 7759482 DOI: 10.1074/Jbc.270.21.12411 |
0.409 |
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| 1995 |
Ylänne J, Huuskonen J, O'Toole TE, Ginsberg MH, Virtanen I, Gahmberg CG. Mutation of the cytoplasmic domain of the integrin beta 3 subunit. Differential effects on cell spreading, recruitment to adhesion plaques, endocytosis, and phagocytosis. The Journal of Biological Chemistry. 270: 9550-7. PMID 7721884 DOI: 10.1074/Jbc.270.16.9550 |
0.327 |
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| 1995 |
Faull RJ, Ginsberg MH. Dynamic regulation of integrins Stem Cells. 13: 38-46. PMID 7719247 DOI: 10.1002/Stem.5530130106 |
0.448 |
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| 1995 |
Shattil SJ, O'Toole T, Eigenthaler M, Thon V, Williams M, Babior BM, Ginsberg MH. Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit. Journal of Cell Biology. 131: 807-816. PMID 7593198 DOI: 10.1083/Jcb.131.3.807 |
0.334 |
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| 1995 |
Du X, Saido TC, Tsubuki S, Indig FE, Williams MJ, Ginsberg MH. Calpain cleavage of the cytoplasmic domain of the integrin beta 3 subunit. The Journal of Biological Chemistry. 270: 26146-51. PMID 7592818 DOI: 10.1074/Jbc.270.44.26146 |
0.405 |
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| 1995 |
Ugarova TP, Zamarron C, Veklich Y, Bowditch RD, Ginsberg MH, Weisel JW, Plow EF. Conformational transitions in the cell binding domain of fibronectin. Biochemistry. 34: 4457-66. PMID 7535564 DOI: 10.1021/Bi00013A039 |
0.421 |
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| 1995 |
Chen Y, O'toole TE, Leong L, Liu B, Diaz-Gonzalez F, Ginsberg MH. Beta 3 integrin-mediated fibrin clot retraction by nucleated cells: differing behavior of alpha IIb beta 3 and alpha v beta 3. Blood. 86: 2606-2615. DOI: 10.1182/Blood.V86.7.2606.Bloodjournal8672606 |
0.303 |
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| 1994 |
Clark EA, Shattil SJ, Ginsberg MH, Bolen J, Brugge JS. Regulation of the protein tyrosine kinase pp72syk by platelet agonists and the integrin αIIbβ3 Journal of Biological Chemistry. 269: 28859-28864. PMID 7961845 |
0.314 |
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| 1994 |
Grove BD, Bowditch R, Gordon T, Del Zoppo G, Ginsberg MH. Restricted endothelial cell expression of gravin in vivo Anatomical Record. 239: 231-242. PMID 7943755 DOI: 10.1002/Ar.1092390302 |
0.357 |
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| 1994 |
Shattil SJ, Ginsberg MH, Brugge JS. Adhesive signaling in platelets Current Opinion in Cell Biology. 6: 695-704. PMID 7530462 DOI: 10.1016/0955-0674(94)90096-5 |
0.411 |
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| 1994 |
Muir TW, Williams MJ, Ginsberg MH, Kent SB. Design and chemical synthesis of a neoprotein structural model for the cytoplasmic domain of a multisubunit cell-surface receptor: integrin alpha IIb beta 3 (platelet GPIIb-IIIa). Biochemistry. 33: 7701-8. PMID 7516703 DOI: 10.1021/Bi00190A025 |
0.415 |
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| 1994 |
Faull RJ, Kovach NL, Harlan JM, Ginsberg MH. Stimulation of integrin-mediated adhesion of T lymphocytes and monocytes: Two mechanisms with divergent biological consequences Journal of Experimental Medicine. 179: 1307-1316. PMID 7511685 DOI: 10.1084/Jem.179.4.1307 |
0.407 |
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| 1994 |
O'Toole TE, Katagiri Y, Faull RJ, Peter K, Tamura R, Quaranta V, Loftus JC, Shattil SJ, Ginsberg MH. Integrin cytoplasmic domains mediate inside-out signal transduction. The Journal of Cell Biology. 124: 1047-59. PMID 7510712 DOI: 10.1083/Jcb.124.6.1047 |
0.354 |
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Chen Y, O'Toole T, Ylanne J, Rosa J, Ginsberg M. A point mutation in the integrin beta 3 cytoplasmic domain (S752-->P) impairs bidirectional signaling through alpha IIb beta 3 (platelet glycoprotein IIb-IIIa) Blood. 84: 1857-1865. DOI: 10.1182/Blood.V84.6.1857.Bloodjournal8461857 |
0.358 |
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| 1994 |
Williams MJ, Hughes PE, O'Toole TE, Ginsberg MH. The inner world of cell adhesion: integrin cytoplasmic domains Trends in Cell Biology. 4: 109-112. DOI: 10.1016/0962-8924(94)90059-0 |
0.436 |
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| 1993 |
Faull RJ, Kovach NL, Harlan JM, Ginsberg MH. Affinity modulation of integrin α5β1: Regulation of the functional response by soluble fibronectin Journal of Cell Biology. 121: 155-162. PMID 8458867 DOI: 10.1083/Jcb.121.1.155 |
0.402 |
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Ylänne J, Chen Y, O'Toole TE, Loftus JC, Takada Y, Ginsberg MH. Distinct functions of integrin alpha and beta subunit cytoplasmic domains in cell spreading and formation of focal adhesions. The Journal of Cell Biology. 122: 223-33. PMID 8314843 DOI: 10.1083/Jcb.122.1.223 |
0.366 |
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| 1993 |
Huang MM, Lipfert L, Cunningham M, Brugge JS, Ginsberg MH, Shattil SJ. Adhesive ligand binding to integrin αIIbβ3 stimulates tyrosine phosphorylation of novel protein substrates before phosphorylation of pp125FAK Journal of Cell Biology. 122: 473-483. PMID 7686553 DOI: 10.1083/Jcb.122.2.473 |
0.423 |
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| 1993 |
Sung K-P, Frojmovic MM, O'toole TE, Zhu C, Ginsberg MH, Chien S. Determination of adhesion force between single cell pairs generated by activated GpIIb-IIIa receptors. Blood. 81: 419-423. DOI: 10.1182/Blood.V81.2.419.Bloodjournal812419 |
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Fujisawa K, Tani P, O'Toole TE, Ginsberg MH, McMillan R. Different specificities of platelet-associated and plasma autoantibodies to platelet GPIIb-IIIa in patients with chronic immune thrombocytopenic purpura Blood. 79: 1441-1446. PMID 1547343 DOI: 10.1182/Blood.V79.6.1441.1441 |
0.325 |
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| 1992 |
Gordon T, Grove B, Loftus JC, O'Toole T, McMillan R, Lindstrom J, Ginsberg MH. Molecular cloning and preliminary characterization of a novel cytoplasmic antigen recognized by myasthenia gravis sera. The Journal of Clinical Investigation. 90: 992-9. PMID 1522245 DOI: 10.1172/Jci115976 |
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| 1992 |
Plow EF, D'Souza SE, Ginsberg MH. Ligand binding to GPIIb-IIIa: A status report Seminars in Thrombosis and Hemostasis. 18: 324-332. PMID 1455250 DOI: 10.1055/S-2007-1002571 |
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Forsyth J, Plow EF, Ginsberg MH. Fibronectin binding to platelets Methods in Enzymology. 215: 311-316. PMID 1435331 DOI: 10.1016/0076-6879(92)15073-L |
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Ginsberg MH, Du X, Plow EF. Inside-out integrin signalling Current Opinion in Cell Biology. 4: 766-771. PMID 1419055 DOI: 10.1016/0955-0674(92)90099-X |
0.453 |
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| 1992 |
Takada Y, Ylänne J, Mandelman D, Puzon W, Ginsberg MH. A point mutation of integrin β2 subunit blocks binding of α5β1 to fibronectin and invasin but not recruitment to adhesion plaques Journal of Cell Biology. 119: 913-921. PMID 1385446 DOI: 10.1083/Jcb.119.4.913 |
0.378 |
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Ginsberg MH, O'Toole TE, Loftus JC, Plow EF. Ligand binding to integrins: Dynamic regulation and common mechanisms Cold Spring Harbor Symposia On Quantitative Biology. 57: 221-232. PMID 1339661 DOI: 10.1101/Sqb.1992.057.01.027 |
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Du XP, Plow EF, Frelinger AL, O'Toole TE, Loftus JC, Ginsberg MH. Ligands "activate" integrin alpha IIb beta 3 (platelet GPIIb-IIIa). Cell. 65: 409-16. PMID 2018974 DOI: 10.1016/0092-8674(91)90458-B |
0.39 |
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| 1991 |
D'Souza SE, Ginsberg MH, Matsueda GR, Plow EF. A discrete sequence in a platelet integrin is involved in ligand recognition Nature. 350: 66-68. PMID 2002847 DOI: 10.1038/350066A0 |
0.4 |
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| 1991 |
O'toole TE, Mandelman D, Forsyth J, Shattil SJ, Plow EF, Ginsberg MH. Modulation of the affinity of integrin alpha IIb beta 3 (GPIIb-IIIa) by the cytoplasmic domain of alpha IIb. Science. 254: 845-847. PMID 1948065 DOI: 10.1126/Science.1948065 |
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| 1991 |
D'Souza SE, Ginsberg MH, Plow EF. Arginyl-glycyl-aspartic acid (RGD): a cell adhesion motif Trends in Biochemical Sciences. 16: 246-250. PMID 1926332 DOI: 10.1016/0968-0004(91)90096-E |
0.405 |
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Gawaz MP, Loftus JC, Bajt ML, Frojmovic MM, Plow EF, Ginsberg MH. Ligand bridging mediates integrin alpha IIb beta 3 (platelet GPIIB-IIIA) dependent homotypic and heterotypic cell-cell interactions. Journal of Clinical Investigation. 88: 1128-1134. PMID 1918367 DOI: 10.1172/Jci115412 |
0.359 |
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| 1991 |
Takada Y, Murphy E, Pil P, Chen C, Ginsberg MH, Hemler ME. Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen. Journal of Cell Biology. 115: 257-266. PMID 1655803 DOI: 10.1083/Jcb.115.1.257 |
0.319 |
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| 1991 |
Frojmovic MM, O'Toole TE, Plow EF, Loftus JC, Ginsberg MH. Platelet glycoprotein IIb-IIIa (alpha IIb beta 3 integrin) confers fibrinogen- and activation-dependent aggregation on heterologous cells. Blood. 78: 369-376. DOI: 10.1182/Blood.V78.2.369.Bloodjournal782369 |
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Fujisawa K, O'Toole TE, Tani P, Loftus JC, Plow EF, Ginsberg MH, McMillan R. Autoantibodies to the presumptive cytoplasmic domain of platelet glycoprotein IIIa in patients with chronic immune thrombocytopenic purpura. Blood. 77: 2207-2213. DOI: 10.1182/Blood.V77.10.2207.Bloodjournal77102207 |
0.323 |
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Loftus JC, O'Toole TE, Plow EF, Glass A, Frelinger AL, Ginsberg MH. A beta 3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation. Science. 249: 915-918. PMID 2392682 DOI: 10.1126/Science.2392682 |
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O'Toole TE, Loftus JC, Du X, Glass AA, Ruggeri ZM, Shattil SJ, Plow EF, Ginsberg MH. Affinity modulation of the alpha IIb beta 3 integrin (platelet GPIIb-IIIa) is an intrinsic property of the receptor. Molecular Biology of the Cell. 1: 883-893. PMID 2100193 DOI: 10.1091/Mbc.1.12.883 |
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Ginsberg MH, Loftus JC, D'Souza S, Plow EF. Ligand binding to integrins: Common and ligand specific recognition mechanisms Cell Differentiation and Development. 32: 203-213. PMID 2099237 DOI: 10.1016/0922-3371(90)90033-S |
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Aiken ML, Ginsberg MH, Byers-Ward V, Plow EF. Effects of OKM5, a monoclonal antibody to glycoprotein IV, on platelet aggregation and thrombospondin surface expression. Blood. 76: 2501-9. PMID 1702328 DOI: 10.1182/Blood.V76.12.2501.2501 |
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Ginsberg MH, Frelinger AL, Lam SCT, Forsyth J, McMillan R, Plow EF, Shattil SJ. Analysis of platelet aggregation disorders based on flow cytometric analysis of membrane glycoprotein IIb-IIIa with conformation-specific monoclonal antibodies. Blood. 76: 2017-2023. DOI: 10.1182/Blood.V76.10.2017.Bloodjournal76102017 |
0.406 |
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| 1989 |
Tranqui L, Andrieux A, Hudry-Clergeon G, Ryckewaert JJ, Soyez S, Chapel A, Ginsberg MH, Plow EF, Marguerie G. Differential structural requirements for fibrinogen binding to platelets and to endothelial cells. Journal of Cell Biology. 108: 2519-2527. PMID 2738096 DOI: 10.1083/Jcb.108.6.2519 |
0.374 |
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Lam SCT, Plow EF, Ginsberg MH. Platelet membrane glycoprotein IIb heavy chain forms a complex with glycoprotein IIIa that binds Arg-Gly-Asp peptides Blood. 73: 1513-1518. PMID 2713490 DOI: 10.1182/Blood.V73.6.1513.1513 |
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O'Toole TE, Loftus JC, Plow EF, Glass AA, Harper JR, Ginsberg MH. Efficient surface expression of platelet GPIIb-IIIa requires both subunits Blood. 74: 14-18. DOI: 10.1182/Blood.V74.1.14.14 |
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Languino L, Colella S, Zanetti A, Andrieux A, Ryckewaert J, Charon M, Marchisio P, Plow E, Ginsberg M, Marguerie G. Fibrinogen-endothelial cell interaction in vitro: a pathway mediated by an Arg-Gly-Asp recognition specificity Blood. 73: 734-742. DOI: 10.1182/Blood.V73.3.734.Bloodjournal733734 |
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| 1988 |
Uzan G, Frachet P, Lajmanovich A, Prandini M‐, Denarier E, Duperray A, Loftus J, Ginsberg M, Plow E, Marguerie G. cDNA clones for human platelet GPIIb corresponding to mRNA from megakaryocytes and HEL cells. Evidence for an extensive homology to other Arg-Gly-Asp adhesion receptors. Febs Journal. 171: 87-93. PMID 3422188 DOI: 10.1111/J.1432-1033.1988.Tb13762.X |
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Ginsberg MH, Loftus JC, Plow EF. Cytoadhesins, integrins, and platelets Thrombosis and Haemostasis. 59: 1-6. PMID 3283991 DOI: 10.1055/S-0038-1642555 |
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D'Souza SE, Ginsberg MH, Burke TA, Lam SCT, Plow EF. Localization of an Arg-Gly-Asp recognition site within an integrin adhesion receptor. Science. 242: 91-93. PMID 3262922 DOI: 10.1126/Science.3262922 |
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Russell M, Seligsohn U, Coller B, Ginsberg M, Skoglund P, Quertermous T. Structural integrity of the glycoprotein IIb and IIIa genes in Glanzmann thrombasthenia patients from Israel. Blood. 72: 1833-1836. DOI: 10.1182/Blood.V72.5.1833.Bloodjournal7251833 |
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|
| 1988 |
Dejana E, Languino L, Colella S, Corbascio G, Plow E, Ginsberg M, Marchisio P. The localization of a platelet GpIIb-IIIa-related protein in endothelial cell adhesion structures Blood. 71: 566-572. DOI: 10.1182/Blood.V71.3.566.566 |
0.39 |
|
| 1987 |
Aiken ML, Ginsberg MH, Plow EF. Mechanisms for expression of thrombospondin on the platelet cell surface. Seminars in Thrombosis and Hemostasis. 13: 307-16. PMID 3686022 DOI: 10.1055/S-2007-1003506 |
0.33 |
|
| 1987 |
Duperray A, Berthier R, Chagnon E, Ryckewaert JJ, Ginsberg M, Plow E, Marguerie G. Biosynthesis and processing of platelet GPIIb-IIIa in human megakaryocytes. Journal of Cell Biology. 104: 1665-1673. PMID 3108266 DOI: 10.1083/Jcb.104.6.1665 |
0.342 |
|
| 1987 |
Plow EF, Pierschbacher MD, Ruoslahti E, Marguerie G, Ginsberg MH. Arginyl-glycyl-aspartic acid sequences and fibrinogen binding to platelets Blood. 70: 110-115. PMID 3036276 DOI: 10.1182/Blood.V70.1.110.Bloodjournal701110 |
0.348 |
|
| 1987 |
Aiken ML, Ginsberg MH, Plow EF. Divalent cation-dependent and independent surface expression of thrombospondin on thrombin-stimulated human platelets. Blood. 69: 58-64. PMID 3024762 DOI: 10.1182/Blood.V69.1.58.58 |
0.355 |
|
| 1987 |
Loftus JC, Plow EF, Frelinger AL, D'Souza SE, Dixon D, Lacy J, Sorge J, Ginsberg MH. Molecular cloning and chemical synthesis of a region of platelet glycoprotein IIb involved in adhesive function Proceedings of the National Academy of Sciences of the United States of America. 84: 7114-7118. PMID 2444974 DOI: 10.1073/Pnas.84.20.7114 |
0.36 |
|
| 1986 |
Terkeltaub R, Smeltzer D, Curtiss LK, Ginsberg MH. Low density lipoprotein inhibits the physical interaction of phlogistic crystals and inflammatory cells. Arthritis and Rheumatism. 29: 363-70. PMID 3964313 DOI: 10.1002/Art.1780290309 |
0.305 |
|
| 1986 |
Aiken ML, Ginsberg MH, Plow EF. Identification of a new class of inducible receptors on platelets. Thrombospondin interacts with platelets via a GPIIb-IIIa-independent mechanism. The Journal of Clinical Investigation. 78: 1713-6. PMID 3782477 DOI: 10.1172/Jci112767 |
0.389 |
|
| 1986 |
Courtois G, Ryckewaert J, Woods VL, Ginsberg MH, Plow EF, Marguerie GA. Expression of intracellular fibrinogen on the surface of stimulated platelets. Febs Journal. 159: 61-67. PMID 3743572 DOI: 10.1111/J.1432-1033.1986.Tb09833.X |
0.38 |
|
| 1986 |
Wencel-Drake JD, Dahlback B, White JG, Ginsberg MH. Ultrastructural localization of coagulation factor V in human platelets Blood. 68: 244-249. PMID 3521762 DOI: 10.1182/Blood.V68.1.244.244 |
0.323 |
|
| 1986 |
Miles LA, Ginsberg MH, White JG, Plow EF. Plasminogen interacts with human platelets through two distinct mechanisms Journal of Clinical Investigation. 77: 2001-2009. PMID 3086385 DOI: 10.1172/Jci112529 |
0.376 |
|
| 1986 |
Berman CL, Yeo EL, Wencel-Drake JD, Furie BC, Ginsberg MH, Furie B. A platelet alpha granule membrane protein that is associated with the plasma membrane after activation. Characterization and subcellular localization of platelet activation-dependent granule-external membrane protein. The Journal of Clinical Investigation. 78: 130-7. PMID 2941452 DOI: 10.1172/Jci112542 |
0.371 |
|
| 1986 |
Ginsberg MH, Lightsey A, Kunicki TJ, Kaufmann A, Marguerie G, Plow EF. Divalent cation regulation of the surface orientation of platelet membrane glycoprotein IIb. Correlation with fibrinogen binding function and definition of a novel variant of Glanzmann's thrombasthenia. The Journal of Clinical Investigation. 78: 1103-11. PMID 2428841 DOI: 10.1172/Jci112667 |
0.377 |
|
| 1986 |
Plow EF, Loftus JC, Levin EG, Fair DS, Dixon D, Forsyth J, Ginsberg MH. Immunologic relationship between platelet membrane glycoprotein GPIIb/IIIa and cell surface molecules expressed by a variety of cells Proceedings of the National Academy of Sciences of the United States of America. 83: 6002-6006. PMID 2426709 DOI: 10.1073/Pnas.83.16.6002 |
0.378 |
|
| 1986 |
Pytela R, Pierschbacher MD, Ginsberg MH, Plow EF, Ruoslahti E. Platelet membrane glycoprotein IIb/IIIa: Member of a family of Arg-Gly-Asp-specific adhesion receptors Science. 231: 1559-1562. PMID 2420006 DOI: 10.1126/Science.2420006 |
0.415 |
|
| 1985 |
Plow EF, Marguerie GA, Ginsberg MH. Fibronectin binding to thrombin-stimulated platelets: Evidence for fibrin(ogen) independent and dependent pathways Blood. 66: 26-32. PMID 4005431 DOI: 10.1182/Blood.V66.1.26.Bloodjournal66126 |
0.413 |
|
| 1985 |
Plow EF, Pierschbacher MD, Ruoslahti E, Marguerie GA, Ginsberg MH. The effect of Arg-Gly-Asp-containing peptides on fibrinogen and von Willebrand factor binding to platelets Proceedings of the National Academy of Sciences of the United States of America. 82: 8057-8061. PMID 3877935 DOI: 10.1073/Pnas.82.23.8057 |
0.374 |
|
| 1985 |
Painter RG, Gaarde W, Ginsberg MH. Direct evidence for the interaction of platelet surface membrane proteins GPIIb and III with cytoskeletal components: Protein crosslinking studies Journal of Cellular Biochemistry. 27: 277-290. PMID 3157694 DOI: 10.1002/Jcb.240270309 |
0.344 |
|
| 1985 |
Marguerie GA, Ginsberg MH, Plow EF. Fibrinogen and platelet function Advances in Experimental Medicine and Biology. 192: 41-54. PMID 3010672 DOI: 10.1007/978-1-4615-9442-0_4 |
0.36 |
|
| 1985 |
Wencel-Drake JD, Painter RG, Zimmerman TS, Ginsberg MH. Ultrastructural localization of human platelet thrombospondin, fibrinogen, fibronectin, and von Willebrand factor in frozen thin section Blood. 65: 929-938. PMID 2579691 DOI: 10.1182/Blood.V65.4.929.Bloodjournal654929 |
0.309 |
|
| 1985 |
Plow EF, McEver RP, Coller BS, Woods VL, Marguerie GA, Ginsberg MH. Related binding mechanisms for fibrinogen, fibronectin, von Willebrand factor, and thrombospondin on thrombin-stimulated human platelets. Blood. 66: 724-727. DOI: 10.1182/Blood.V66.3.724.Bloodjournal663724 |
0.399 |
|
| 1984 |
Erickson LA, Ginsberg MH, Loskutoff DJ. Detection and partial characterization of an inhibitor of plasminogen activator in human platelets Journal of Clinical Investigation. 74: 1465-1472. PMID 6434594 DOI: 10.1172/Jci111559 |
0.34 |
|
| 1984 |
Painter RG, Ginsberg MH. Centripetal myosin redistribution in thrombin-stimulated platelets. Relationship to platelet factor 4 secretion Experimental Cell Research. 155: 198-212. PMID 6386495 DOI: 10.1016/0014-4827(84)90781-X |
0.357 |
|
| 1984 |
Shadle PJ, Ginsberg MH, Plow EF, Barondes SH. Platelet-collagen adhesion: inhibition by a monoclonal antibody that binds glycoprotein IIb. The Journal of Cell Biology. 99: 2056-60. PMID 6238974 DOI: 10.1083/Jcb.99.6.2056 |
0.342 |
|
| 1984 |
Marguerie GA, Thomas Maison N, Ginsberg MH, Plow EF. The platelet-fibrinogen interaction. Evidence for proximity of the Aα chain of fibrinogen to platelet membrane glycoprotein IIb/III European Journal of Biochemistry. 139: 5-11. PMID 6230229 DOI: 10.1111/J.1432-1033.1984.Tb07968.X |
0.347 |
|
| 1983 |
Ryo R, Nakeff A, Huang SS, Ginsberg M, Deuel TF. New synthesis of a platelet-specific protein: platelet factor 4 synthesis in a megakaryocyte-enriched rabbit bone marrow culture system. Journal of Cell Biology. 96: 515-520. PMID 6833369 DOI: 10.1083/Jcb.96.2.515 |
0.314 |
|
| 1983 |
Ginsberg MH, Forsyth J, Lightsey A, Chediak J, Plow EF. Reduced surface expression and binding of fibronectin by thrombin-stimulated thrombasthenic platelets Journal of Clinical Investigation. 71: 619-624. PMID 6826726 DOI: 10.1172/Jci110808 |
0.382 |
|
| 1983 |
Ginsberg MH, Wencel JD, White JG, Plow EF. Binding of fibronectin to α-granule-deficient platelets Journal of Cell Biology. 97: 571-573. PMID 6309863 DOI: 10.1083/Jcb.97.2.571 |
0.415 |
|
| 1983 |
Terkeltaub R, Tenner AJ, Kozin F, Ginsberg MH. Plasma protein binding by monosodium urate crystals. Analysis of two-dimensional gel electrophoresis Arthritis and Rheumatism. 26: 775-783. PMID 6305372 DOI: 10.1002/Art.1780260612 |
0.302 |
|
| 1982 |
Jaques BC, Ginsberg MH. The role of cell surface proteins in platelet stimulation by monosodium urate crystals Arthritis and Rheumatism. 25: 508-521. PMID 7082398 DOI: 10.1002/Art.1780250504 |
0.337 |
|
| 1982 |
Fernandez MF, Ginsberg MH, Ruggeri ZM, Batlle FJ, Zimmerman TS. Multimeric structure of platelet factor VIII/von Willebrand factor: The presence of larger multimers and their reassociation with thrombin-stimulated platelets Blood. 60: 1132-1138. PMID 6982084 DOI: 10.1182/Blood.V60.5.1132.1132 |
0.318 |
|
| 1982 |
Painter RG, Ginsberg M. Concanavalin A induces interactions between surface glycoproteins and the platelet cytoskeleton Journal of Cell Biology. 92: 565-573. PMID 6460776 DOI: 10.1083/Jcb.92.2.565 |
0.388 |
|
| 1981 |
Ginsberg MH, Plow EF. Fibronectin expression on the platelet surface occurs in concert with secretion Journal of Supramolecular and Cellular Biochemistry. 17: 91-98. PMID 7198692 DOI: 10.1002/Jsscb.380170111 |
0.369 |
|
| 1980 |
Ginsberg MH, Painter RG, Forsyth J, Birdwell C, Plow EF. Thrombin increases expression of fibronectin antigen on the platelet surface Proceedings of the National Academy of Sciences of the United States of America. 77: 1049-1053. PMID 6987662 DOI: 10.1073/Pnas.77.2.1049 |
0.387 |
|
| 1980 |
Ginsberg MH, Taylor L, Painter RG. The mechanism of thrombin-induced platelet factor 4 secretion Blood. 55: 661-668. PMID 6986924 DOI: 10.1182/Blood.V55.4.661.Bloodjournal554661 |
0.315 |
|
| 1979 |
Ginsberg MH, Painter RG, Birdwell C, Plow EF. The detection, immunofluorescent localization, and thrombin induced release of human platelet-associated fibronectin antigen Journal of Supramolecular and Cellular Biochemistry. 11: 167-174. PMID 398428 DOI: 10.1002/Jss.400110206 |
0.346 |
|
| 1979 |
Plow EF, Birdwell C, Ginsberg MH. Identification and quantitation of platelet-associated fibronectin antigen Journal of Clinical Investigation. 63: 540-543. PMID 372243 DOI: 10.1172/Jci109334 |
0.315 |
|
| 1977 |
Kozin F, Ginsberg M, Karasek V, Skosey J, McCarty D. Protein binding to monosodium urate crystals and its effect on platelet degranulation. Advances in Experimental Medicine and Biology. 768: 201-208. PMID 855768 DOI: 10.1007/978-1-4684-3285-5_29 |
0.316 |
|
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