Lawrence M. Szewczuk, Ph.D. - Publications

Affiliations: 
2004 University of Pennsylvania, Philadelphia, PA, United States 
Area:
Biochemistry, Medical Biophysics

16 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Lin H, Zeng J, Xie R, Schulz MJ, Tedesco R, Qu J, Erhard KF, Mack JF, Raha K, Rendina AR, Szewczuk LM, Kratz PM, Jurewicz AJ, Cecconie T, Martens S, et al. Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors. Acs Medicinal Chemistry Letters. 7: 217-22. PMID 26985301 DOI: 10.1021/acsmedchemlett.5b00214  1
2013 Brandt M, Szewczuk LM, Zhang H, Hong X, McCormick PM, Lewis TS, Graham TI, Hung ST, Harper-Jones AD, Kerrigan JJ, Wang DY, Dul E, Hou W, Ho TF, Meek TD, et al. Development of a high-throughput screen to detect inhibitors of TRPS1 sumoylation. Assay and Drug Development Technologies. 11: 308-25. PMID 23772552 DOI: 10.1089/adt.2012.501  1
2009 Szewczuk LM, Penning TM. Co-oxidation by cyclooxygenases. Current Protocols in Toxicology / Editorial Board, Mahin D. Maines (Editor-in-Chief) ... [Et Al.]. Unit4.30. PMID 23045015 DOI: 10.1002/0471140856.tx0430s42  1
2009 Szewczuk LM, Tarrant MK, Cole PA. Protein phosphorylation by semisynthesis: from paper to practice. Methods in Enzymology. 462: 1-24. PMID 19632467 DOI: 10.1016/S0076-6879(09)62001-2  1
2008 Szewczuk LM, Tarrant MK, Sample V, Drury WJ, Zhang J, Cole PA. Analysis of serotonin N-acetyltransferase regulation in vitro and in live cells using protein semisynthesis. Biochemistry. 47: 10407-19. PMID 18771288 DOI: 10.1021/bi801189d  1
2007 Szewczuk LM, Saldanha SA, Ganguly S, Bowers EM, Javoroncov M, Karanam B, Culhane JC, Holbert MA, Klein DC, Abagyan R, Cole PA. De novo discovery of serotonin N-acetyltransferase inhibitors. Journal of Medicinal Chemistry. 50: 5330-8. PMID 17924613 DOI: 10.1021/jm0706463  1
2007 Yang M, Culhane JC, Szewczuk LM, Jalili P, Ball HL, Machius M, Cole PA, Yu H. Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine. Biochemistry. 46: 8058-65. PMID 17569509 DOI: 10.1021/bi700664y  1
2007 Yang M, Culhane JC, Szewczuk LM, Gocke CB, Brautigam CA, Tomchick DR, Machius M, Cole PA, Yu H. Structural basis of histone demethylation by LSD1 revealed by suicide inactivation. Nature Structural & Molecular Biology. 14: 535-9. PMID 17529991 DOI: 10.1038/nsmb1255  1
2007 Szewczuk LM, Culhane JC, Yang M, Majumdar A, Yu H, Cole PA. Mechanistic analysis of a suicide inactivator of histone demethylase LSD1. Biochemistry. 46: 6892-902. PMID 17511474 DOI: 10.1021/bi700414b  1
2006 Culhane JC, Szewczuk LM, Liu X, Da G, Marmorstein R, Cole PA. A mechanism-based inactivator for histone demethylase LSD1. Journal of the American Chemical Society. 128: 4536-7. PMID 16594666 DOI: 10.1021/ja0602748  1
2005 Park JH, Gopishetty S, Szewczuk LM, Troxel AB, Harvey RG, Penning TM. Formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dGuo) by PAH o-quinones: involvement of reactive oxygen species and copper(II)/copper(I) redox cycling. Chemical Research in Toxicology. 18: 1026-37. PMID 15962938 DOI: 10.1021/tx050001a  1
2005 Szewczuk LM, Lee SH, Blair IA, Penning TM. Viniferin formation by COX-1: evidence for radical intermediates during co-oxidation of resveratrol. Journal of Natural Products. 68: 36-42. PMID 15679314 DOI: 10.1021/np049702i  1
2005 Bauman DR, Rudnick SI, Szewczuk LM, Jin Y, Gopishetty S, Penning TM. Development of nonsteroidal anti-inflammatory drug analogs and steroid carboxylates selective for human aldo-keto reductase isoforms: potential antineoplastic agents that work independently of cyclooxygenase isozymes. Molecular Pharmacology. 67: 60-8. PMID 15475569 DOI: 10.1124/mol.104.006569  1
2004 Szewczuk LM, Penning TM. Mechanism-based inactivation of COX-1 by red wine m-hydroquinones: a structure-activity relationship study. Journal of Natural Products. 67: 1777-82. PMID 15568761 DOI: 10.1021/np0498410  1
2004 Szewczuk LM, Forti L, Stivala LA, Penning TM. Resveratrol is a peroxidase-mediated inactivator of COX-1 but not COX-2: a mechanistic approach to the design of COX-1 selective agents. The Journal of Biological Chemistry. 279: 22727-37. PMID 15020596 DOI: 10.1074/jbc.M314302200  1
2001 Cudic P, Behenna DC, Yu MK, Kruger RG, Szewczuk LM, McCafferty DG. Synthesis of P(1)-Citronellyl-P(2)-alpha-D-pyranosyl pyrophosphates as potential substrates for the E. coli undecaprenyl-pyrophosphoryl-N-acetylglucoseaminyl transferase MurG. Bioorganic & Medicinal Chemistry Letters. 11: 3107-10. PMID 11720853 DOI: 10.1016/S0960-894X(01)00653-9  1
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