James I. Fells, Ph.D. - Publications

Affiliations: 
2009 The University of Memphis, Memphis, TN, United States 
Area:
Pharmaceutical Chemistry

22/27 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Yu W, Liu J, Clausen D, Yu Y, Duffy JL, Wang M, Xu S, Deng L, Takao S, Chung CC, Myers RW, Klein DJ, Fells JI, Holloway MK, Wu J, et al. Discovery of Ethyl Ketone-Based Highly Selective HDACs 1, 2, 3 Inhibitors for HIV Latency Reactivation with Minimum Cellular Potency Serum Shift and Reduced hERG Activity. Journal of Medicinal Chemistry. PMID 33797924 DOI: 10.1021/acs.jmedchem.0c02150  0.4
2020 Clausen DJ, Liu J, Yu W, Duffy JL, Chung CC, Myers RW, Klein DJ, Fells J, Holloway K, Wu J, Wu G, Howell BJ, Barnard RJO, Kozlowski J. Development of a selective HDAC inhibitor aimed at reactivating the HIV latent reservoir. Bioorganic & Medicinal Chemistry Letters. 30: 127367. PMID 32738976 DOI: 10.1016/J.Bmcl.2020.127367  0.4
2020 Liu J, Kelly J, Yu W, Clausen D, Yu Y, Kim H, Duffy JL, Chung CC, Myers RW, Carroll S, Klein DJ, Fells J, Holloway MK, Wu J, Wu G, et al. Selective Class I HDAC Inhibitors Based on Aryl Ketone Zinc Binding Induce HIV-1 Protein for Clearance. Acs Medicinal Chemistry Letters. 11: 1476-1483. PMID 32676157 DOI: 10.1021/Acsmedchemlett.0C00302  0.4
2020 Yu W, Liu J, Yu Y, Zhang V, Clausen D, Kelly J, Wolkenberg S, Beshore D, Duffy JL, Chang CC, Myers RW, Klein DJ, Fells J, Holloway K, Wu J, et al. Discovery of ethyl ketone-based HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation. Bioorganic & Medicinal Chemistry Letters. 127197. PMID 32331932 DOI: 10.1016/J.Bmcl.2020.127197  0.4
2015 Patil R, Szabó E, Fells JI, Balogh A, Lim KG, Fujiwara Y, Norman DD, Lee SC, Balazs L, Thomas F, Patil S, Emmons-Thompson K, Boler A, Strobos J, McCool SW, et al. Combined mitigation of the gastrointestinal and hematopoietic acute radiation syndromes by an LPA2 receptor-specific nonlipid agonist. Chemistry & Biology. 22: 206-16. PMID 25619933 DOI: 10.1016/J.Chembiol.2014.12.009  0.4
2014 Patil R, Fells JI, Szabó E, Lim KG, Norman DD, Balogh A, Patil S, Strobos J, Miller DD, Tigyi GJ. Design and synthesis of sulfamoyl benzoic acid analogues with subnanomolar agonist activity specific to the LPA2 receptor. Journal of Medicinal Chemistry. 57: 7136-40. PMID 25100502 DOI: 10.1021/Jm5007116  0.6
2014 Morales-Lázaro SL, Serrano-Flores B, Llorente I, Hernández-García E, González-Ramírez R, Banerjee S, Miller D, Gududuru V, Fells J, Norman D, Tigyi G, Escalante-Alcalde D, Rosenbaum T. Structural determinants of the transient receptor potential 1 (TRPV1) channel activation by phospholipid analogs. The Journal of Biological Chemistry. 289: 24079-90. PMID 25035428 DOI: 10.1074/Jbc.M114.572503  0.6
2014 Fells JI, Lee SC, Norman DD, Tsukahara R, Kirby JR, Nelson S, Seibel W, Papoian R, Patil R, Miller DD, Parrill AL, Pham TC, Baker DL, Bittman R, Tigyi G. Targeting the hydrophobic pocket of autotaxin with virtual screening of inhibitors identifies a common aromatic sulfonamide structural motif. The Febs Journal. 281: 1017-28. PMID 24314137 DOI: 10.1111/Febs.12674  0.6
2013 Fells JI, Lee SC, Fujiwara Y, Norman DD, Lim KG, Tsukahara R, Liu J, Patil R, Miller DD, Kirby RJ, Nelson S, Seibel W, Papoian R, Parrill AL, Baker DL, et al. Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface. Molecular Pharmacology. 84: 415-24. PMID 23793291 DOI: 10.1124/Mol.113.087080  0.6
2013 Kiss GN, Lee SC, Fells JI, Liu J, Valentine WJ, Fujiwara Y, Thompson KE, Yates CR, Sümegi B, Tigyi G. Mitigation of radiation injury by selective stimulation of the LPA(2) receptor. Biochimica Et Biophysica Acta. 1831: 117-25. PMID 23127512 DOI: 10.1016/J.Bbalip.2012.08.020  0.6
2013 Fells J, Lee SC, Norman D, Fujiwara Y, Tsukahara R, Liu J, Kirby J, Nelson S, Tigyi G. Abstract 5680: Identification and characterization of a novel class of ATX inhibitors. Cancer Research. 73: 5680-5680. DOI: 10.1158/1538-7445.Am2013-5680  0.4
2012 Kiss GN, Fells JI, Gupte R, Lee SC, Liu J, Nusser N, Lim KG, Ray RM, Lin FT, Parrill AL, Sümegi B, Miller DD, Tigyi G. Virtual screening for LPA2-specific agonists identifies a nonlipid compound with antiapoptotic actions. Molecular Pharmacology. 82: 1162-73. PMID 22968304 DOI: 10.1124/Mol.112.079699  0.6
2012 Gotoh M, Fujiwara Y, Yue J, Liu J, Lee S, Fells J, Uchiyama A, Murakami-Murofushi K, Kennel S, Wall J, Patil R, Gupte R, Balazs L, Miller DD, Tigyi GJ. Controlling cancer through the autotaxin-lysophosphatidic acid receptor axis. Biochemical Society Transactions. 40: 31-6. PMID 22260662 DOI: 10.1042/Bst20110608  0.4
2011 Gupte R, Patil R, Liu J, Wang Y, Lee SC, Fujiwara Y, Fells J, Bolen AL, Emmons-Thompson K, Yates CR, Siddam A, Panupinthu N, Pham TC, Baker DL, Parrill AL, et al. Benzyl and naphthalene methylphosphonic acid inhibitors of autotaxin with anti-invasive and anti-metastatic activity. Chemmedchem. 6: 922-35. PMID 21465666 DOI: 10.1002/Cmdc.201000425  0.6
2010 Fells JI, Tsukahara R, Liu J, Tigyi G, Parrill AL. 2D binary QSAR modeling of LPA3 receptor antagonism. Journal of Molecular Graphics & Modelling. 28: 828-33. PMID 20356772 DOI: 10.1016/J.Jmgm.2010.03.002  0.6
2009 Fells JI, Tsukahara R, Liu J, Tigyi G, Parrill AL. Structure-based drug design identifies novel LPA3 antagonists. Bioorganic & Medicinal Chemistry. 17: 7457-64. PMID 19800804 DOI: 10.1016/J.Bmc.2009.09.022  0.6
2009 Zhang H, Xu X, Gajewiak J, Tsukahara R, Fujiwara Y, Liu J, Fells JI, Perygin D, Parrill AL, Tigyi G, Prestwich GD. Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo. Cancer Research. 69: 5441-9. PMID 19509223 DOI: 10.1158/0008-5472.Can-09-0302  0.6
2009 Williams JR, Khandoga AL, Goyal P, Fells JI, Perygin DH, Siess W, Parrill AL, Tigyi G, Fujiwara Y. Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation. The Journal of Biological Chemistry. 284: 17304-19. PMID 19366702 DOI: 10.1074/Jbc.M109.003194  0.6
2008 Fells JI, Tsukahara R, Fujiwara Y, Liu J, Perygin DH, Osborne DA, Tigyi G, Parrill AL. Identification of non-lipid LPA3 antagonists by virtual screening. Bioorganic & Medicinal Chemistry. 16: 6207-17. PMID 18467108 DOI: 10.1016/J.Bmc.2008.04.035  0.6
2008 Valentine WJ, Fells JI, Perygin DH, Mujahid S, Yokoyama K, Fujiwara Y, Tsukahara R, Van Brocklyn JR, Parrill AL, Tigyi G. Subtype-specific residues involved in ligand activation of the endothelial differentiation gene family lysophosphatidic acid receptors. The Journal of Biological Chemistry. 283: 12175-87. PMID 18316373 DOI: 10.1074/Jbc.M708847200  0.6
2008 Pham TC, Fells JI, Osborne DA, North EJ, Naor MM, Parrill AL. Molecular recognition in the sphingosine 1-phosphate receptor family. Journal of Molecular Graphics & Modelling. 26: 1189-201. PMID 18165127 DOI: 10.1016/J.Jmgm.2007.11.001  0.6
2004 Holdsworth G, Osborne DA, Pham TT, Fells JI, Hutchinson G, Milligan G, Parrill AL. A single amino acid determines preference between phospholipids and reveals length restriction for activation of the S1P4 receptor. Bmc Biochemistry. 5: 12. PMID 15298705 DOI: 10.1186/1471-2091-5-12  0.6
Low-probability matches
2020 Fells JI, Ai X, Weinglass A, Feng W, Lei Y, Finley M, Hoveyda HR, Fraser GL, Machacek M. Identification of Free Fatty Acid Receptor 2 Agonists Using Virtual Screening. Bioorganic & Medicinal Chemistry Letters. 127460. PMID 32755680 DOI: 10.1016/J.Bmcl.2020.127460  0.01
2017 Gao YD, Hu Y, Crespo A, Wang D, Armacost KA, Fells JI, Fradera X, Wang H, Wang H, Sherborne B, Verras A, Peng Z. Workflows and performances in the ranking prediction of 2016 D3R Grand Challenge 2: lessons learned from a collaborative effort. Journal of Computer-Aided Molecular Design. PMID 28986733 DOI: 10.1007/s10822-017-0072-z  0.01
2017 Fradera X, Verras A, Hu Y, Wang D, Wang H, Fells JI, Armacost KA, Crespo A, Sherborne B, Wang H, Peng Z, Gao YD. Performance of multiple docking and refinement methods in the pose prediction D3R prospective Grand Challenge 2016. Journal of Computer-Aided Molecular Design. PMID 28913710 DOI: 10.1007/s10822-017-0053-2  0.01
2017 Sanders JM, Beshore DC, Culberson JC, Fells JI, Imbriglio JE, Gunaydin H, Haidle AM, Labroli M, Mattioni BE, Sciammetta N, Shipe WD, Sheridan RP, Suen LM, Verras A, Walji AM, et al. Informing the selection of screening hit series with in silico absorption, distribution, metabolism, excretion, and toxicity profiles. Journal of Medicinal Chemistry. PMID 28418656 DOI: 10.1021/Acs.Jmedchem.6B01577  0.01
2014 Morales-Lázaro SL, Serrano-Flores B, Llorente I, Hernández-García E, González-Ramírez R, Banerjee S, Miller D, Gududuru V, Fells J, Norman D, Tigyi G, Escalante-Alcalde D, Rosenbaum T. Structural determinants of the transient receptor potential 1 (TRPV1) channel activation by phospholipid analogs. Journal of Biological Chemistry. 289: 33876-33876. DOI: 10.1074/Jbc.A114.572503  0.01
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