Year |
Citation |
Score |
2021 |
Li Y, McCabe M, Podila L, Tracy TS, Tweedie D. Case Study 4: Application of Basic Enzyme Kinetics to Metabolism Studies-Real-Life Examples. Methods in Molecular Biology (Clifton, N.J.). 2342: 665-684. PMID 34272711 DOI: 10.1007/978-1-0716-1554-6_23 |
0.302 |
|
2021 |
Seibert E, Tracy TS. Fundamentals of Enzyme Kinetics: Michaelis-Menten and Non-Michaelis-Type (Atypical) Enzyme Kinetics. Methods in Molecular Biology (Clifton, N.J.). 2342: 3-27. PMID 34272689 DOI: 10.1007/978-1-0716-1554-6_1 |
0.327 |
|
2016 |
Flora DR, Rettie AE, Brundage RC, Tracy TS. CYP2C9 Genotype-Dependent Warfarin Pharmacokinetics: Impact of CYP2C9 Genotype on R- and S-Warfarin and Their Oxidative Metabolites. Journal of Clinical Pharmacology. PMID 27539372 DOI: 10.1002/Jcph.813 |
0.454 |
|
2016 |
Bostick CD, Hickey KM, Wollenberg LA, Flora DR, Tracy TS, Gannett PM. Immobilized Cytochrome P450 for Monitoring of P450-P450 Interactions and Metabolism. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 26961240 DOI: 10.1124/Dmd.115.067637 |
0.445 |
|
2015 |
Tracy TS, Chaudhry AS, Prasad B, Thummel KE, Schuetz EG, Zhong XB, Tien YC, Jeong H, Pan X, Shireman LM, Tay-Sontheimer J, Lin YS. Interindividual Variability in Cytochrome P450-Mediated Drug Metabolism. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 26681736 DOI: 10.1124/Dmd.115.067900 |
0.484 |
|
2015 |
Bostick CD, Flora DR, Gannett PM, Tracy TS, Lederman D. Nanoscale electron transport measurements of immobilized cytochrome P450 proteins. Nanotechnology. 26: 155102. PMID 25804257 DOI: 10.1088/0957-4484/26/15/155102 |
0.381 |
|
2014 |
Ramsden D, Tweedie DJ, Chan TS, Tracy TS. Altered CYP2C9 activity following modulation of CYP3A4 levels in human hepatocytes: an example of protein-protein interactions. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 42: 1940-6. PMID 25157098 DOI: 10.1124/Dmd.114.057901 |
0.367 |
|
2014 |
Li Y, McCabe M, Podila L, Tracy TS, Tweedie DJ. Case study 3. Application of basic enzyme kinetics to metabolism studies: real-life examples. Methods in Molecular Biology (Clifton, N.J.). 1113: 441-60. PMID 24523124 DOI: 10.1007/978-1-62703-758-7_20 |
0.417 |
|
2014 |
Seibert E, Tracy TS. Different enzyme kinetic models. Methods in Molecular Biology (Clifton, N.J.). 1113: 23-35. PMID 24523107 DOI: 10.1007/978-1-62703-758-7_3 |
0.419 |
|
2014 |
Seibert E, Tracy TS. Fundamentals of enzyme kinetics. Methods in Molecular Biology (Clifton, N.J.). 1113: 9-22. PMID 24523106 DOI: 10.1007/978-1-62703-758-7_2 |
0.375 |
|
2014 |
Wollenberg LA, Kabulski JL, Powell MJ, Chen J, Flora DR, Tracy TS, Gannett PM. The use of immobilized cytochrome P4502C9 in PMMA-based plug flow bioreactors for the production of drug metabolites. Applied Biochemistry and Biotechnology. 172: 1293-306. PMID 24166101 DOI: 10.1007/S12010-013-0537-Z |
0.421 |
|
2013 |
Jett JE, Lederman D, Wollenberg LA, Li D, Flora DR, Bostick CD, Tracy TS, Gannett PM. Measurement of electron transfer through cytochrome P450 protein on nanopillars and the effect of bound substrates. Journal of the American Chemical Society. 135: 3834-40. PMID 23427827 DOI: 10.1021/Ja309104G |
0.356 |
|
2012 |
Wollenberg LA, Jett JE, Wu Y, Flora DR, Wu N, Tracy TS, Gannett PM. Selective filling of nanowells in nanowell arrays fabricated using polystyrene nanosphere lithography with cytochrome P450 enzymes. Nanotechnology. 23: 385101. PMID 22947619 DOI: 10.1088/0957-4484/23/38/385101 |
0.321 |
|
2012 |
Hodge LS, Downs LS, Chura JC, Thomas SG, Callery PS, Soisson AP, Kramer P, Wolfe SS, Tracy TS. Localized delivery of chemotherapy to the cervix for radiosensitization. Gynecologic Oncology. 127: 121-5. PMID 22796462 DOI: 10.1016/J.Ygyno.2012.07.097 |
0.695 |
|
2012 |
Subramanian M, Agrawal V, Sandee D, Tam HK, Miller WL, Tracy TS. Effect of P450 oxidoreductase variants on the metabolism of model substrates mediated by CYP2C9.1, CYP2C9.2, and CYP2C9.3. Pharmacogenetics and Genomics. 22: 590-7. PMID 22547083 DOI: 10.1097/Fpc.0B013E3283544062 |
0.44 |
|
2012 |
Flora DR, Tracy TS. Development of an in vitro system with human liver microsomes for phenotyping of CYP2C9 genetic polymorphisms with a mechanism-based inactivator. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 836-42. PMID 22205778 DOI: 10.1124/Dmd.111.043372 |
0.501 |
|
2011 |
Hodge LS, Taub ME, Tracy TS. The deaminated metabolite of gemcitabine, 2',2'-difluorodeoxyuridine, modulates the rate of gemcitabine transport and intracellular phosphorylation via deoxycytidine kinase. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 2013-6. PMID 21832002 DOI: 10.1124/Dmd.111.040790 |
0.721 |
|
2011 |
Hodge LS, Taub ME, Tracy TS. Effect of its deaminated metabolite, 2',2'-difluorodeoxyuridine, on the transport and toxicity of gemcitabine in HeLa cells. Biochemical Pharmacology. 81: 950-6. PMID 21291869 DOI: 10.1016/J.Bcp.2011.01.016 |
0.711 |
|
2011 |
Zhou J, Tracy TS, Remmel RP. Correlation between bilirubin glucuronidation and estradiol-3-gluronidation in the presence of model UDP-glucuronosyltransferase 1A1 substrates/inhibitors. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 322-9. PMID 21030469 DOI: 10.1124/Dmd.110.035030 |
0.404 |
|
2010 |
Sandee D, Morrissey K, Agrawal V, Tam HK, Kramer MA, Tracy TS, Giacomini KM, Miller WL. Effects of genetic variants of human P450 oxidoreductase on catalysis by CYP2D6 in vitro. Pharmacogenetics and Genomics. 20: 677-86. PMID 20940534 DOI: 10.1097/Fpc.0B013E32833F4F9B |
0.466 |
|
2010 |
Zhou J, Tracy TS, Remmel RP. Bilirubin glucuronidation revisited: proper assay conditions to estimate enzyme kinetics with recombinant UGT1A1. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 38: 1907-11. PMID 20668247 DOI: 10.1124/Dmd.110.033829 |
0.358 |
|
2010 |
Subramanian M, Tam H, Zheng H, Tracy TS. CYP2C9-CYP3A4 protein-protein interactions: role of the hydrophobic N terminus. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 38: 1003-9. PMID 20215413 DOI: 10.1124/Dmd.109.030155 |
0.418 |
|
2010 |
Zhou J, Tracy TS, Remmel RP. Glucuronidation of dihydrotestosterone and trans-androsterone by recombinant UDP-glucuronosyltransferase (UGT) 1A4: evidence for multiple UGT1A4 aglycone binding sites. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 38: 431-40. PMID 20007295 DOI: 10.1124/Dmd.109.028712 |
0.398 |
|
2010 |
Subramanian M, Tracy TS. Allosteric enzyme- and transporter-based interactions Enzyme- and Transporter-Based Drug-Drug Interactions: Progress and Future Challenges. 497-515. DOI: 10.1007/978-1-4419-0840-7_20 |
0.351 |
|
2009 |
Subramanian M, Low M, Locuson CW, Tracy TS. CYP2D6-CYP2C9 protein-protein interactions and isoform-selective effects on substrate binding and catalysis. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 1682-9. PMID 19448135 DOI: 10.1124/Dmd.109.026500 |
0.477 |
|
2009 |
Yang M, Kabulski JL, Wollenberg L, Chen X, Subramanian M, Tracy TS, Lederman D, Gannett PM, Wu N. Electrocatalytic drug metabolism by CYP2C9 bonded to a self-assembled monolayer-modified electrode. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 892-9. PMID 19171677 DOI: 10.1124/Dmd.108.025452 |
0.395 |
|
2009 |
Hutzler JM, Balogh LM, Zientek M, Kumar V, Tracy TS. Mechanism-based inactivation of cytochrome P450 2C9 by tienilic acid and (+/-)-suprofen: a comparison of kinetics and probe substrate selection. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 59-65. PMID 18838506 DOI: 10.1124/Dmd.108.023358 |
0.372 |
|
2008 |
Mosher CM, Hummel MA, Tracy TS, Rettie AE. Functional analysis of phenylalanine residues in the active site of cytochrome P450 2C9. Biochemistry. 47: 11725-34. PMID 18922023 DOI: 10.1021/Bi801231M |
0.73 |
|
2008 |
Hummel MA, Gannett PM, Aguilar J, Tracy TS. Substrate proton to heme distances in CYP2C9 allelic variants and alterations by the heterotropic activator, dapsone. Archives of Biochemistry and Biophysics. 475: 175-83. PMID 18485885 DOI: 10.1016/J.Abb.2008.04.034 |
0.753 |
|
2008 |
Kramer MA, Tracy TS. Studying cytochrome P450 kinetics in drug metabolism. Expert Opinion On Drug Metabolism & Toxicology. 4: 591-603. PMID 18484917 DOI: 10.1517/17425255.4.5.591 |
0.408 |
|
2008 |
Kumar V, Brundage RC, Oetting WS, Leppik IE, Tracy TS. Differential genotype dependent inhibition of CYP2C9 in humans. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 1242-8. PMID 18378563 DOI: 10.1124/Dmd.108.020396 |
0.446 |
|
2007 |
Hodge LS, Tracy TS. Alterations in drug disposition during pregnancy: implications for drug therapy. Expert Opinion On Drug Metabolism & Toxicology. 3: 557-71. PMID 17696806 DOI: 10.1517/17425225.3.4.557 |
0.734 |
|
2007 |
Wei L, Locuson CW, Tracy TS. Polymorphic variants of CYP2C9: mechanisms involved in reduced catalytic activity. Molecular Pharmacology. 72: 1280-8. PMID 17686967 DOI: 10.1124/Mol.107.036178 |
0.441 |
|
2007 |
Locuson CW, Wienkers LC, Jones JP, Tracy TS. CYP2C9 protein interactions with cytochrome b(5): effects on the coupling of catalysis. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 1174-81. PMID 17446262 DOI: 10.1124/Dmd.107.014910 |
0.376 |
|
2007 |
Locuson CW, Gannett PM, Ayscue R, Tracy TS. Use of simple docking methods to screen a virtual library for heteroactivators of cytochrome P450 2C9. Journal of Medicinal Chemistry. 50: 1158-65. PMID 17311370 DOI: 10.1021/Jm060706P |
0.451 |
|
2007 |
Locuson CW, Hutzler JM, Tracy TS. Visible spectra of type II cytochrome P450-drug complexes: evidence that "incomplete" heme coordination is common. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 614-22. PMID 17251307 DOI: 10.1124/Dmd.106.012609 |
0.324 |
|
2007 |
Zgheib NK, Frye RF, Tracy TS, Romkes M, Branch RA. Evaluation of flurbiprofen urinary ratios as in vivo indices for CYP2C9 activity. British Journal of Clinical Pharmacology. 63: 477-87. PMID 17054666 DOI: 10.1111/J.1365-2125.2006.02781.X |
0.388 |
|
2007 |
Hodge LS, Tracy TS. Alterations in drug disposition during pregnancy: Expert Opinion On Drug Metabolism & Toxicology. 3: 557-571. DOI: 10.1517/17425255.3.4.557 |
0.732 |
|
2006 |
Tracy TS. Atypical cytochrome p450 kinetics: implications for drug discovery. Drugs in R&D. 7: 349-63. PMID 17073518 DOI: 10.2165/00126839-200607060-00004 |
0.465 |
|
2006 |
Kumar V, Wahlstrom JL, Rock DA, Warren CJ, Gorman LA, Tracy TS. CYP2C9 inhibition: impact of probe selection and pharmacogenetics on in vitro inhibition profiles. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 1966-75. PMID 16963489 DOI: 10.1124/Dmd.106.010926 |
0.491 |
|
2006 |
Locuson CW, Tracy TS. Identification of binding sites of non-I-helix water molecules in mammalian cytochromes p450. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 1954-7. PMID 16956955 DOI: 10.1124/Dmd.106.011890 |
0.338 |
|
2006 |
Zgheib NK, Frye RF, Tracy TS, Romkes M, Branch RA. Validation of incorporating flurbiprofen into the Pittsburgh cocktail. Clinical Pharmacology and Therapeutics. 80: 257-63. PMID 16952492 DOI: 10.1016/j.clpt.2006.06.005 |
0.349 |
|
2006 |
Kumar V, Rock DA, Warren CJ, Tracy TS, Wahlstrom JL. Enzyme source effects on CYP2C9 kinetics and inhibition. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 1903-8. PMID 16928789 DOI: 10.1124/Dmd.106.010249 |
0.425 |
|
2006 |
Kumar V, Locuson CW, Sham YY, Tracy TS. Amiodarone analog-dependent effects on CYP2C9-mediated metabolism and kinetic profiles. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 1688-96. PMID 16815961 DOI: 10.1124/Dmd.106.010678 |
0.495 |
|
2006 |
Gannett PM, Kabulski J, Perez FA, Liu Z, Lederman D, Locuson CW, Ayscue RR, Thomsen NM, Tracy TS. Preparation, characterization, and substrate metabolism of gold-immobilized cytochrome P450 2C9. Journal of the American Chemical Society. 128: 8374-5. PMID 16802783 DOI: 10.1021/Ja0608693 |
0.451 |
|
2006 |
Locuson CW, Gannett PM, Tracy TS. Heteroactivator effects on the coupling and spin state equilibrium of CYP2C9. Archives of Biochemistry and Biophysics. 449: 115-29. PMID 16545770 DOI: 10.1016/J.Abb.2006.02.004 |
0.365 |
|
2006 |
Hummel MA, Tracy TS, Hutzler JM, Wahlstrom JL, Zhou Y, Rock DA. Influence of fluorescent probe size and cytochrome b5 on drug-drug interactions in CYP2C9 Journal of Biomolecular Screening. 11: 303-309. PMID 16490777 DOI: 10.1177/1087057105285612 |
0.744 |
|
2006 |
Sanga M, Younis IR, Tirumalai PS, Bland TM, Banaszewska M, Konat GW, Tracy TS, Gannett PM, Callery PS. Epoxidation of the methamphetamine pyrolysis product, trans-phenylpropene, to trans-phenylpropylene oxide by CYP enzymes and stereoselective glutathione adduct formation. Toxicology and Applied Pharmacology. 211: 148-56. PMID 16038959 DOI: 10.1016/J.Taap.2005.06.017 |
0.355 |
|
2005 |
Bland TM, Haining RL, Tracy TS, Callery PS. CYP2C-catalyzed delta9-tetrahydrocannabinol metabolism: kinetics, pharmacogenetics and interaction with phenytoin. Biochemical Pharmacology. 70: 1096-103. PMID 16112652 DOI: 10.1016/J.Bcp.2005.07.007 |
0.43 |
|
2005 |
Hummel MA, Locuson CW, Gannett PM, Rock DA, Mosher CM, Rettie AE, Tracy TS. CYP2C9 genotype-dependent effects on in vitro drug-drug interactions: switching of benzbromarone effect from inhibition to activation in the CYP2C9.3 variant. Molecular Pharmacology. 68: 644-51. PMID 15955872 DOI: 10.1124/Mol.105.013763 |
0.781 |
|
2005 |
Kotlyar M, Brauer LH, Tracy TS, Hatsukami DK, Harris J, Bronars CA, Adson DE. Inhibition of CYP2D6 activity by bupropion. Journal of Clinical Psychopharmacology. 25: 226-9. PMID 15876900 DOI: 10.1097/01.Jcp.0000162805.46453.E3 |
0.384 |
|
2005 |
Tirumalai PS, Shakleya DM, Gannett PM, Callery PS, Bland TM, Tracy TS. Conversion of methamphetamine to N-methyl-methamphetamine in formalin solutions. Journal of Analytical Toxicology. 29: 48-53. PMID 15808013 DOI: 10.1093/Jat/29.1.48 |
0.31 |
|
2005 |
Tracy TS, Venkataramanan R, Glover DD, Caritis SN. Temporal changes in drug metabolism (CYP1A2, CYP2D6 and CYP3A Activity) during pregnancy. American Journal of Obstetrics and Gynecology. 192: 633-9. PMID 15696014 DOI: 10.1016/J.Ajog.2004.08.030 |
0.45 |
|
2005 |
Kolwankar D, Glover DD, Ware JA, Tracy TS. Expression and function of ABCB1 and ABCG2 in human placental tissue. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 524-9. PMID 15640379 DOI: 10.1124/Dmd.104.002261 |
0.372 |
|
2004 |
Tracy TS, Hummel MA. Modeling kinetic data from in vitro drug metabolism enzyme experiments. Drug Metabolism Reviews. 36: 231-42. PMID 15237853 DOI: 10.1081/Dmr-120033999 |
0.761 |
|
2004 |
Hummel MA, Gannett PM, Aguilar JS, Tracy TS. Effector-mediated alteration of substrate orientation in cytochrome P450 2C9. Biochemistry. 43: 7207-14. PMID 15170358 DOI: 10.1021/Bi036158O |
0.75 |
|
2004 |
Hummel MA, Dickmann LJ, Rettie AE, Haining RL, Tracy TS. Differential activation of CYP2C9 variants by dapsone. Biochemical Pharmacology. 67: 1831-41. PMID 15130760 DOI: 10.1016/J.Bcp.2004.01.017 |
0.765 |
|
2004 |
Komoroski BJ, Zhang S, Cai H, Hutzler JM, Frye R, Tracy TS, Strom SC, Lehmann T, Ang CY, Cui YY, Venkataramanan R. Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 32: 512-8. PMID 15100173 DOI: 10.1124/Dmd.32.5.512 |
0.488 |
|
2003 |
Tracy TS. Atypical enzyme kinetics: their effect on in vitro-in vivo pharmacokinetic predictions and drug interactions. Current Drug Metabolism. 4: 341-6. PMID 14529366 DOI: 10.2174/1389200033489280 |
0.454 |
|
2003 |
Hutzler JM, Wienkers LC, Wahlstrom JL, Carlson TJ, Tracy TS. Activation of cytochrome P450 2C9-mediated metabolism: mechanistic evidence in support of kinetic observations. Archives of Biochemistry and Biophysics. 410: 16-24. PMID 12559973 DOI: 10.1016/S0003-9861(02)00665-3 |
0.375 |
|
2002 |
Hutzler JM, Kolwankar D, Hummel MA, Tracy TS. Activation of CYP2C9-mediated metabolism by a series of dapsone analogs: kinetics and structural requirements. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 1194-200. PMID 12386124 DOI: 10.1124/Dmd.30.11.1194 |
0.763 |
|
2002 |
Tracy TS, Hutzler JM, Haining RL, Rettie AE, Hummel MA, Dickmann LJ. Polymorphic variants (CYP2C9*3 and CYP2C9*5) and the F114L active site mutation of CYP2C9: effect on atypical kinetic metabolism profiles. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 385-90. PMID 11901091 DOI: 10.1124/Dmd.30.4.385 |
0.774 |
|
2002 |
Hutzler JM, Tracy TS. Atypical kinetic profiles in drug metabolism reactions. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 355-62. PMID 11901086 DOI: 10.1124/Dmd.30.4.355 |
0.469 |
|
2001 |
Hutzler JM, Frye RF, Korzekwa KR, Branch RA, Huang SM, Tracy TS. Minimal in vivo activation of CYP2C9-mediated flurbiprofen metabolism by dapsone. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 14: 47-52. PMID 11457649 DOI: 10.1016/S0928-0987(01)00144-0 |
0.416 |
|
2001 |
Hutzler JM, Hauer MJ, Tracy TS. Dapsone activation of cyp2c9-mediated metabolism: Evidence for activation of multiple substrates and a two-site model Drug Metabolism and Disposition. 29: 1029-1034. PMID 11408370 |
0.372 |
|
2001 |
Tracy TS, Rybeck BF, James DG, Knopp JB, Gannett PM. Stability of benzodiazepines in formaldehyde solutions. Journal of Analytical Toxicology. 25: 166-73. PMID 11327348 DOI: 10.1093/Jat/25.3.166 |
0.382 |
|
2001 |
Gannett PM, Hailu S, Daft J, James D, Rybeck B, Tracy TS. In vitro reaction of formaldehyde with fenfluramine: conversion to N-methyl fenfluramine. Journal of Analytical Toxicology. 25: 88-92. PMID 11300512 DOI: 10.1093/Jat/25.2.88 |
0.33 |
|
1999 |
Zhang W, Parentau H, Greenly RL, Metz CA, Aggarwal S, Wainer IW, Tracy TS. Effect of protein-calorie malnutrition on cytochromes P450 and glutathione S-transferase. European Journal of Drug Metabolism and Pharmacokinetics. 24: 141-7. PMID 10510741 |
0.301 |
|
1999 |
Tracy TS, Korzekwa KR, Gonzalez FJ, Wainer IW. Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamil British Journal of Clinical Pharmacology. 47: 545-552. PMID 10336579 DOI: 10.1046/J.1365-2125.1999.00923.X |
0.342 |
|
1999 |
Hutzler JM, Rettie AE, Haining RL, Tracy TS. Flurbiprofen metabolism by chimeric P450 2C9/19 enzymes Clinical Pharmacology and Therapeutics. 65: 164. |
0.361 |
|
1998 |
Glover DD, McRobie DJ, Tracy TS. Effects of gestational and overt diabetes on placental cytochromes P450 and glutathione S-transferase. Primary Care Update For Ob/Gyns. 5: 189. PMID 10838356 DOI: 10.1016/S1068-607X(98)00111-5 |
0.314 |
|
1998 |
Korzekwa KR, Krishnamachary N, Shou M, Ogai A, Parise RA, Rettie AE, Gonzalez FJ, Tracy TS. Evaluation of atypical cytochrome P450 kinetics with two-substrate models: evidence that multiple substrates can simultaneously bind to cytochrome P450 active sites. Biochemistry. 37: 4137-47. PMID 9521735 DOI: 10.1021/Bi9715627 |
0.488 |
|
1997 |
Tracy TS, Marra C, Wrighton SA, Gonzalez FJ, Korzekwa KR. Involvement of multiple cytochrome P450 isoforms in naproxen O-demethylation. European Journal of Clinical Pharmacology. 52: 293-8. PMID 9248768 DOI: 10.1007/s002280050293 |
0.358 |
|
1996 |
McRobie DJ, Glover DD, Tracy TS. Regiospecificity of placental metabolism by cytochromes P450 and glutathione S-transferase Gynecologic and Obstetric Investigation. 42: 154-158. PMID 8938464 DOI: 10.1159/000291934 |
0.357 |
|
1996 |
Tracy TS, Marra C, Wrighton SA, Gonzalez FJ, Korzekwa KR. Studies of flurbiprofen 4'-hydroxylation. Additional evidence suggesting the sole involvement of cytochrome P450 2C9. Biochemical Pharmacology. 52: 1305-9. PMID 8937439 DOI: 10.1016/0006-2952(96)00501-1 |
0.352 |
|
1995 |
Tracy TS, Rosenbluth BW, Wrighton SA, Gonzalez FJ, Korzekwa KR. Role of cytochrome P450 2C9 and an allelic variant in the 4'-hydroxylation of (R)- and (S)-flurbiprofen. Biochemical Pharmacology. 49: 1269-75. PMID 7763308 DOI: 10.1016/0006-2952(95)00048-5 |
0.382 |
|
1995 |
Tracy TS. Stereochemistry in pharmacotherapy: When mirror images are not identical Annals of Pharmacotherapy. 29: 161-165. PMID 7756715 DOI: 10.1177/106002809502900211 |
0.405 |
|
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