Jane X. Kelly, Ph.D. - Publications

Affiliations: 
2003 Portland State University, Portland, OR, United States 
Area:
Biochemistry, Pharmaceutical Chemistry

35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Smilkstein MJ, Pou S, Krollenbrock A, Bleyle LA, Dodean RA, Frueh L, Hinrichs DJ, Li Y, Martinson T, Munar MY, Winter RW, Bruzual I, Whiteside S, Nilsen A, Koop DR, ... Kelly JX, et al. ELQ-331 as a prototype for extremely durable chemoprotection against malaria. Malaria Journal. 18: 291. PMID 31455339 DOI: 10.1186/s12936-019-2921-9  0.52
2019 Dodean RA, Kancharla P, Li Y, Melendez V, Read L, Bane C, Vesely B, Kreishman-Deitrick M, Black C, Li Q, Sciotti RJ, Olmeda R, Luong TL, Gaona H, Potter B, ... ... Kelly JX, et al. Discovery and Structural Optimization of Acridones as Broad-Spectrum Antimalarials. Journal of Medicinal Chemistry. PMID 30852885 DOI: 10.1021/acs.jmedchem.8b01961  0.52
2017 Frueh L, Li Y, Mather M, Li Q, Pou S, Nilsen A, Winter RW, Forquer I, Pershing A, Xie LH, Smilkstein MJ, Caridha D, Campbell RF, Sciotti RJ, Kreishman-Deitrick M, ... Kelly JX, et al. Alkoxycarbonate Ester Prodrugs of Preclinical Drug Candidate ELQ-300 for Prophylaxis and Treatment of Malaria. Acs Infectious Diseases. PMID 28927276 DOI: 10.1021/acsinfecdis.7b00062  0.52
2017 Gunsaru B, Burgess SJ, Morrill W, Kelly JX, Shomloo S, Smilkstein MJ, Liebmann K, Peyton DH. Simplified Reversed Chloroquines to Overcome Malaria Resistance to Quinoline-based Drugs. Antimicrobial Agents and Chemotherapy. PMID 28193646 DOI: 10.1128/AAC.01913-16  0.56
2016 Foss MH, Pou S, Davidson PM, Dunaj JL, Winter RW, Pou S, Licon MH, Doh JK, Li Y, Kelly JX, Dodean RA, Koop DR, Riscoe MK, Purdy GE. Diphenylether-Modified 1,2-Diamines with Improved Drug Properties for Development against Mycobacterium tuberculosis. Acs Infectious Diseases. 2: 500-508. PMID 27626102 DOI: 10.1021/acsinfecdis.6b00052  0.4
2016 Abugrain ME, Lu W, Li Y, Serrill JD, Brumsted CJ, Osborn AR, Alani A, Ishmael JE, Kelly JX, Mahmud T. Interrogating the Tailoring Steps of Pactamycin Biosynthesis and Accessing New Pactamycin Analogues. Chembiochem : a European Journal of Chemical Biology. PMID 27305101 DOI: 10.1002/cbic.201600261  0.56
2016 Stickles AM, Smilkstein MJ, Morrisey JM, Li Y, Forquer IP, Kelly JX, Pou S, Winter RW, Nilsen A, Vaidya AB, Riscoe MK. Atovaquone and ELQ-300 combination therapy: A novel dual-site cytochrome bc1 inhibition strategy for malaria. Antimicrobial Agents and Chemotherapy. PMID 27270285 DOI: 10.1128/AAC.00791-16  0.56
2016 Abugrain ME, Lu W, Li Y, Serrill JD, Brumsted CJ, Osborn AR, Alani A, Ishmael JE, Kelly JX, Mahmud T. Cover Picture: Interrogating the Tailoring Steps of Pactamycin Biosynthesis and Accessing New Pactamycin Analogues (ChemBioChem 17/2016) Chembiochem. 17: 1579. DOI: 10.1002/cbic.201600434  0.56
2015 Kancharla P, Kelly JX, Reynolds KA. Synthesis and Structure-Activity Relationships of Tambjamines and B-Ring Functionalized Prodiginines as Potent Antimalarials. Journal of Medicinal Chemistry. 58: 7286-309. PMID 26305125 DOI: 10.1021/acs.jmedchem.5b00560  0.56
2015 Miley GP, Pou S, Winter R, Nilsen A, Li Y, Kelly JX, Stickles AM, Mather MW, Forquer IP, Pershing AM, White K, Shackleford D, Saunders J, Chen G, Ting LM, et al. ELQ-300 prodrugs for enhanced delivery and single dose cure of malaria. Antimicrobial Agents and Chemotherapy. PMID 26124159 DOI: 10.1128/AAC.01183-15  0.56
2015 Stickles AM, Ting LM, Morrisey JM, Li Y, Mather MW, Meermeier E, Pershing AM, Forquer IP, Miley GP, Pou S, Winter RW, Hinrichs DJ, Kelly JX, Kim K, Vaidya AB, et al. Inhibition of Cytochrome bc1 as a Strategy for Single-Dose, Multi-Stage Antimalarial Therapy. The American Journal of Tropical Medicine and Hygiene. 92: 1195-201. PMID 25918204 DOI: 10.4269/ajtmh.14-0553  0.56
2015 Vining OB, Medina RA, Mitchell EA, Videau P, Li D, Serrill JD, Kelly JX, Gerwick WH, Proteau PJ, Ishmael JE, McPhail KL. Depsipeptide companeramides from a Panamanian marine cyanobacterium associated with the coibamide producer. Journal of Natural Products. 78: 413-20. PMID 25562664 DOI: 10.1021/np5007907  0.56
2014 Kancharla P, Lu W, Salem SM, Kelly JX, Reynolds KA. Stereospecific synthesis of 23-hydroxyundecylprodiginines and analogues and conversion to antimalarial premarineosins via a Rieske oxygenase catalyzed bicyclization. The Journal of Organic Chemistry. 79: 11674-89. PMID 25380131 DOI: 10.1021/jo5023553  0.56
2014 Nilsen A, Miley GP, Forquer IP, Mather MW, Katneni K, Li Y, Pou S, Pershing AM, Stickles AM, Ryan E, Kelly JX, Doggett JS, White KL, Hinrichs DJ, Winter RW, et al. Discovery, synthesis, and optimization of antimalarial 4(1H)-quinolone-3-diarylethers. Journal of Medicinal Chemistry. 57: 3818-34. PMID 24720377 DOI: 10.1021/jm500147k  0.56
2013 Almabruk KH, Lu W, Li Y, Abugreen M, Kelly JX, Mahmud T. Mutasynthesis of fluorinated pactamycin analogues and their antimalarial activity Organic Letters. 15: 1678-1681. PMID 23521145 DOI: 10.1021/ol4004614  0.56
2013 Nilsen A, LaCrue AN, White KL, Forquer IP, Cross RM, Marfurt J, Mather MW, Delves MJ, Shackleford DM, Saenz FE, Morrisey JM, Steuten J, Mutka T, Li Y, Wirjanata G, ... ... Kelly JX, et al. Quinolone-3-diarylethers: a new class of antimalarial drug. Science Translational Medicine. 5: 177ra37. PMID 23515079 DOI: 10.1126/scitranslmed.3005029  0.56
2012 Pou S, Winter RW, Nilsen A, Kelly JX, Li Y, Doggett JS, Riscoe EW, Wegmann KW, Hinrichs DJ, Riscoe MK. Sontochin as a guide to the development of drugs against chloroquine-resistant malaria. Antimicrobial Agents and Chemotherapy. 56: 3475-80. PMID 22508305 DOI: 10.1128/AAC.00100-12  0.56
2011 Papireddy K, Smilkstein M, Kelly JX, Shweta, Salem SM, Alhamadsheh M, Haynes SW, Challis GL, Reynolds KA. Antimalarial activity of natural and synthetic prodiginines. Journal of Medicinal Chemistry. 54: 5296-306. PMID 21736388 DOI: 10.1021/jm200543y  0.56
2011 Winter R, Kelly JX, Smilkstein MJ, Hinrichs D, Koop DR, Riscoe MK. Optimization of endochin-like quinolones for antimalarial activity. Experimental Parasitology. 127: 545-51. PMID 21040724 DOI: 10.1016/j.exppara.2010.10.016  0.56
2010 Burgess SJ, Kelly JX, Shomloo S, Wittlin S, Brun R, Liebmann K, Peyton DH. Synthesis, structure-activity relationship, and mode-of-action studies of antimalarial reversed chloroquine compounds. Journal of Medicinal Chemistry. 53: 6477-89. PMID 20684562 DOI: 10.1021/jm1006484  0.56
2010 Andrews S, Burgess SJ, Skaalrud D, Kelly JX, Peyton DH. Reversal agent and linker variants of reversed chloroquines: activities against Plasmodium falciparum. Journal of Medicinal Chemistry. 53: 916-9. PMID 20088608 DOI: 10.1021/jm900972u  0.56
2009 Kelly JX, Smilkstein MJ, Brun R, Wittlin S, Cooper RA, Lane KD, Janowsky A, Johnson RA, Dodean RA, Winter R, Hinrichs DJ, Riscoe MK. Discovery of dual function acridones as a new antimalarial chemotype. Nature. 459: 270-3. PMID 19357645 DOI: 10.1038/nature07937  0.56
2008 Smilkstein MJ, Forquer I, Kanazawa A, Kelly JX, Winter RW, Hinrichs DJ, Kramer DM, Riscoe MK. A drug-selected Plasmodium falciparum lacking the need for conventional electron transport. Molecular and Biochemical Parasitology. 159: 64-8. PMID 18308406 DOI: 10.1016/j.molbiopara.2008.01.002  0.56
2008 Winter RW, Kelly JX, Smilkstein MJ, Dodean R, Hinrichs D, Riscoe MK. Antimalarial quinolones: synthesis, potency, and mechanistic studies. Experimental Parasitology. 118: 487-97. PMID 18082162 DOI: 10.1016/j.exppara.2007.10.016  0.56
2008 Dodean RA, Kelly JX, Peyton D, Gard GL, Riscoe MK, Winter RW. Synthesis and heme-binding correlation with antimalarial activity of 3,6-bis-(omega-N,N-diethylaminoamyloxy)-4,5-difluoroxanthone. Bioorganic & Medicinal Chemistry. 16: 1174-83. PMID 18023189 DOI: 10.1016/j.bmc.2007.10.083  0.56
2007 Kelly JX, Smilkstein MJ, Cooper RA, Lane KD, Johnson RA, Janowsky A, Dodean RA, Hinrichs DJ, Winter R, Riscoe M. Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum. Antimicrobial Agents and Chemotherapy. 51: 4133-40. PMID 17846138 DOI: 10.1128/AAC.00669-07  0.56
2007 Kelly JX, Winter RW, Braun TP, Osei-Agyemang M, Hinrichs DJ, Riscoe MK. Selective killing of the human malaria parasite Plasmodium falciparum by a benzylthiazolium dye. Experimental Parasitology. 116: 103-10. PMID 17266952 DOI: 10.1016/j.exppara.2006.12.001  0.56
2006 Burgess SJ, Selzer A, Kelly JX, Smilkstein MJ, Riscoe MK, Peyton DH. A chloroquine-like molecule designed to reverse resistance in Plasmodium falciparum. Journal of Medicinal Chemistry. 49: 5623-5. PMID 16942036 DOI: 10.1021/jm060399n  0.56
2006 Winter RW, Kelly JX, Smilkstein MJ, Dodean R, Bagby GC, Rathbun RK, Levin JI, Hinrichs D, Riscoe MK. Evaluation and lead optimization of anti-malarial acridones. Experimental Parasitology. 114: 47-56. PMID 16828746 DOI: 10.1016/j.exppara.2006.03.014  0.56
2005 Riscoe M, Kelly JX, Winter R. Xanthones as antimalarial agents: Discovery, mode of action, and optimization Current Medicinal Chemistry. 12: 2539-2549. PMID 16250876 DOI: 10.2174/092986705774370709  0.56
2004 Sriwilaijaroen N, Kelly JX, Riscoe M, Wilairat P. CyQUANT cell proliferation assay as a fluorescence-based method for in vitro screening of antimalarial activity Southeast Asian Journal of Tropical Medicine and Public Health. 35: 840-844. PMID 15916078  0.56
2004 Smilkstein M, Sriwilaijaroen N, Kelly JX, Wilairat P, Riscoe M. Simple and Inexpensive Fluorescence-Based Technique for High-Throughput Antimalarial Drug Screening Antimicrobial Agents and Chemotherapy. 48: 1803-1806. PMID 15105138 DOI: 10.1128/AAC.48.5.1803-1806.2004  0.56
2003 Kelly JX, Ignatushchenko MV, Bouwer HG, Peyton DH, Hinrichs DJ, Winter RW, Riscoe M. Antileishmanial drug development: exploitation of parasite heme dependency. Molecular and Biochemical Parasitology. 126: 43-9. PMID 12554083 DOI: 10.1016/S0166-6851(02)00248-7  0.56
2002 Kelly JX, Winter RW, Cornea A, Peyton DH, Hinrichs DJ, Riscoe M. The kinetics of uptake and accumulation of 3,6-bis-omega-diethylamino-amyloxyxanthone by the human malaria parasite Plasmodium falciparum. Molecular and Biochemical Parasitology. 123: 47-54. PMID 12165388 DOI: 10.1016/S0166-6851(02)00118-4  0.56
2002 Kelly JX, Winter R, Peyton DH, Hinrichs DJ, Riscoe M. Optimization of xanthones for antimalarial activity: the 3,6-bis-omega-diethylaminoalkoxyxanthone series. Antimicrobial Agents and Chemotherapy. 46: 144-50. PMID 11751125 DOI: 10.1128/AAC.46.1.144-150.2002  0.56
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