Pankaj K. Singh, Ph.D. - Publications

Affiliations: 
2007 University of Nebraska Medical Center, Omaha, NE, United States 
Area:
Biochemistry, Oncology, Molecular Biology

36 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Mundry C, Eberle KC, Singh PK, Hollingsworth MA, Mehla K. Local and systemic immunosuppression in pancreatic cancer: Targeting the stalwarts in tumor's arsenal. Biochimica Et Biophysica Acta. Reviews On Cancer. 188387. PMID 32579889 DOI: 10.1016/j.bbcan.2020.188387  0.84
2020 Dasgupta A, Shukla SK, Vernucci E, King RJ, Abrego J, Mulder SE, Mullen NJ, Graves G, Buettner K, Thakur R, Murthy D, Attri KS, Wang D, Chaika NV, Pacheco CG, ... ... Singh PK, et al. SIRT1-NOX4 signaling axis regulates cancer cachexia. The Journal of Experimental Medicine. 217. PMID 32441762 DOI: 10.1084/jem.20190745  0.84
2020 Shukla SK, Markov SD, Attri KS, Vernucci E, King RJ, Dasgupta A, Grandgenett PM, Hollingsworth MA, Singh PK, Yu F, Mehla K. Macrophages potentiate STAT3 signaling in skeletal muscles and regulate pancreatic cancer cachexia. Cancer Letters. PMID 32344015 DOI: 10.1016/j.canlet.2020.04.017  0.84
2019 Vernucci E, Abrego J, Gunda V, Shukla SK, Dasgupta A, Rai V, Chaika N, Buettner K, Illies A, Yu F, Lazenby AJ, Swanson BJ, Singh PK. Metabolic Alterations in Pancreatic Cancer Progression. Cancers. 12. PMID 31861288 DOI: 10.3390/cancers12010002  0.56
2019 Mehla K, Singh PK. Metabolic Regulation of Macrophage Polarization in Cancer. Trends in Cancer. 5: 822-834. PMID 31813459 DOI: 10.1016/j.trecan.2019.10.007  0.52
2019 Mehla K, Singh PK. Metabolic Subtyping for Novel Personalized Therapies Against Pancreatic Cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31628144 DOI: 10.1158/1078-0432.CCR-19-2926  0.52
2018 Attri KS, Mehla K, Shukla SK, Singh PK. Microscale Gene Expression Analysis of Tumor-Associated Macrophages. Scientific Reports. 8: 2408. PMID 29402936 DOI: 10.1038/s41598-018-20820-4  0.52
2018 Attri KS, Mehla K, Singh PK. Evaluation of Macrophage Polarization in Pancreatic Cancer Microenvironment Under Hypoxia. Methods in Molecular Biology (Clifton, N.J.). 1742: 265-276. PMID 29330807 DOI: 10.1007/978-1-4939-7665-2_23  0.52
2017 Mehla K, Tremayne J, Grunkemeyer JA, O'Connell KA, Steele MM, Caffrey TC, Zhu X, Yu F, Singh PK, Schultes BC, Madiyalakan R, Nicodemus CF, Hollingsworth MA. Combination of mAb-AR20.5, anti-PD-L1 and PolyICLC inhibits tumor progression and prolongs survival of MUC1.Tg mice challenged with pancreatic tumors. Cancer Immunology, Immunotherapy : Cii. PMID 29204701 DOI: 10.1007/s00262-017-2095-7  0.84
2017 Shukla SK, Purohit V, Mehla K, Gunda V, Chaika NV, Vernucci E, King RJ, Abrego J, Goode GD, Dasgupta A, Illies AL, Gebregiworgis T, Dai B, Augustine JJ, Murthy D, ... ... Singh PK, et al. MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer. Cancer Cell. 32: 392. PMID 28898700 DOI: 10.1016/j.ccell.2017.08.008  0.84
2017 Shukla SK, Purohit V, Mehla K, Gunda V, Chaika NV, Vernucci E, King RJ, Abrego J, Goode GD, Dasgupta A, Illies AL, Gebregiworgis T, Dai B, Augustine JJ, Murthy D, ... ... Singh PK, et al. MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer. Cancer Cell. 32: 71-87.e7. PMID 28697344 DOI: 10.1016/j.ccell.2017.06.004  0.84
2015 Mondal G, Kumar V, Shukla SK, Singh PK, Mahato RI. EGFR Targeted Polymeric Mixed Micelles carrying Gemcitabine for treating Pancreatic Cancer. Biomacromolecules. PMID 26626700 DOI: 10.1021/acs.biomac.5b01419  0.84
2015 Shukla SK, Dasgupta A, Mehla K, Gunda V, Vernucci E, Souchek J, Goode G, King R, Mishra A, Rai I, Nagarajan S, Chaika NV, Yu F, Singh PK. Silibinin-mediated metabolic reprogramming attenuates pancreatic cancer-induced cachexia and tumor growth. Oncotarget. PMID 26510913 DOI: 10.18632/oncotarget.5843  0.84
2014 Shukla SK, Gebregiworgis T, Purohit V, Chaika NV, Gunda V, Radhakrishnan P, Mehla K, Pipinos II, Powers R, Yu F, Singh PK. Metabolic reprogramming induced by ketone bodies diminishes pancreatic cancer cachexia. Cancer & Metabolism. 2: 18. PMID 25228990 DOI: 10.1186/2049-3002-2-18  0.52
2014 Liu X, Caffrey TC, Steele MM, Mohr A, Singh PK, Radhakrishnan P, Kelly DL, Wen Y, Hollingsworth MA. MUC1 regulates cyclin D1 gene expression through p120 catenin and β-catenin. Oncogenesis. 3: e107. PMID 24979278 DOI: 10.1038/oncsis.2014.19  0.84
2014 Stark JL, Mehla K, Chaika N, Acton TB, Xiao R, Singh PK, Montelione GT, Powers R. Structure and function of human DnaJ homologue subfamily a member 1 (DNAJA1) and its relationship to pancreatic cancer. Biochemistry. 53: 1360-72. PMID 24512202 DOI: 10.1021/bi401329a  0.84
2014 Mehla K, Singh PK. MUC1: a novel metabolic master regulator. Biochimica Et Biophysica Acta. 1845: 126-35. PMID 24418575 DOI: 10.1016/j.bbcan.2014.01.001  0.84
2012 Singh D, Singh PK, Chaudhary S, Mehla K, Kumar S. Exome sequencing and advances in crop improvement. Advances in Genetics. 79: 87-121. PMID 22989766 DOI: 10.1016/B978-0-12-394395-8.00003-7  0.52
2012 Dey P, Rachagani S, Chakraborty S, Singh PK, Zhao X, Gurumurthy CB, Anderson JM, Lele S, Hollingsworth MA, Band V, Batra SK. Overexpression of ecdysoneless in pancreatic cancer and its role in oncogenesis by regulating glycolysis. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 6188-98. PMID 22977192 DOI: 10.1158/1078-0432.CCR-12-1789  0.84
2012 Chaika NV, Gebregiworgis T, Lewallen ME, Purohit V, Radhakrishnan P, Liu X, Zhang B, Mehla K, Brown RB, Caffrey T, Yu F, Johnson KR, Powers R, Hollingsworth MA, Singh PK. MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer. Proceedings of the National Academy of Sciences of the United States of America. 109: 13787-92. PMID 22869720 DOI: 10.1073/pnas.1203339109  0.84
2012 Singh PK, Brand RE, Mehla K. MicroRNAs in pancreatic cancer metabolism. Nature Reviews. Gastroenterology & Hepatology. 9: 334-44. PMID 22508159 DOI: 10.1038/nrgastro.2012.63  0.52
2012 Torres MP, Rachagani S, Purohit V, Pandey P, Joshi S, Moore ED, Johansson SL, Singh PK, Ganti AK, Batra SK. Graviola: a novel promising natural-derived drug that inhibits tumorigenicity and metastasis of pancreatic cancer cells in vitro and in vivo through altering cell metabolism. Cancer Letters. 323: 29-40. PMID 22475682 DOI: 10.1016/j.canlet.2012.03.031  0.84
2012 Chaika NV, Yu F, Purohit V, Mehla K, Lazenby AJ, DiMaio D, Anderson JM, Yeh JJ, Johnson KR, Hollingsworth MA, Singh PK. Differential expression of metabolic genes in tumor and stromal components of primary and metastatic loci in pancreatic adenocarcinoma. Plos One. 7: e32996. PMID 22412968 DOI: 10.1371/journal.pone.0032996  0.84
2011 Singh PK, Mehla K, Hollingsworth MA, Johnson KR. Regulation of Aerobic Glycolysis by microRNAs in Cancer. Molecular and Cellular Pharmacology. 3: 125-134. PMID 22792411 DOI: 10.4255/mcpharmacol.11.17  0.84
2011 Eggers JP, Grandgenett PM, Collisson EC, Lewallen ME, Tremayne J, Singh PK, Swanson BJ, Andersen JM, Caffrey TC, High RR, Ouellette M, Hollingsworth MA. Cyclin-dependent kinase 5 is amplified and overexpressed in pancreatic cancer and activated by mutant K-Ras. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 6140-50. PMID 21825040 DOI: 10.1158/1078-0432.CCR-10-2288  0.84
2010 Song Y, Altarejos J, Goodarzi MO, Inoue H, Guo X, Berdeaux R, Kim JH, Goode J, Igata M, Paz JC, Hogan MF, Singh PK, Goebel N, Vera L, Miller N, et al. CRTC3 links catecholamine signalling to energy balance. Nature. 468: 933-9. PMID 21164481 DOI: 10.1038/nature09564  0.84
2010 Behrens ME, Grandgenett PM, Bailey JM, Singh PK, Yi CH, Yu F, Hollingsworth MA. The reactive tumor microenvironment: MUC1 signaling directly reprograms transcription of CTGF. Oncogene. 29: 5667-77. PMID 20697347 DOI: 10.1038/onc.2010.327  0.84
2008 Bailey JM, Swanson BJ, Hamada T, Eggers JP, Singh PK, Caffery T, Ouellette MM, Hollingsworth MA. Sonic hedgehog promotes desmoplasia in pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 5995-6004. PMID 18829478 DOI: 10.1158/1078-0432.CCR-08-0291  0.84
2008 Singh PK, Behrens ME, Eggers JP, Cerny RL, Bailey JM, Shanmugam K, Gendler SJ, Bennett EP, Hollingsworth MA. Phosphorylation of MUC1 by Met modulates interaction with p53 and MMP1 expression. The Journal of Biological Chemistry. 283: 26985-95. PMID 18625714 DOI: 10.1074/jbc.M805036200  0.84
2008 Chaturvedi P, Singh AP, Chakraborty S, Chauhan SC, Bafna S, Meza JL, Singh PK, Hollingsworth MA, Mehta PP, Batra SK. MUC4 mucin interacts with and stabilizes the HER2 oncoprotein in human pancreatic cancer cells. Cancer Research. 68: 2065-70. PMID 18381409 DOI: 10.1158/0008-5472.CAN-07-6041  0.84
2008 Chaturvedi P, Singh AP, Chakraborty S, Chauhan SC, Bafna S, Meza JL, Singh PK, Hollingsworth MA, Mehta PP, Batra SK. MUC4 mucin interacts with and stabilizes the HER2 oncoprotein in human pancreatic cancer cells (Cancer Research (April 1, 2008) 68(2065-2070)) Cancer Research. 68: 3549. DOI: 10.1158/0008-5472.CAN-68-9-COR3  0.84
2008 Swanson BJ, McDermott KM, Singh PK, Eggers JP, Crocker PR, Hollingsworth MA. MUC1 is a counter-receptor for myelin-associated glycoprotein (Siglec-4a) and their interaction contributes to adhesion in pancreatic cancer perineural invasion (Cancer Research (2007) 67, (10222-10229)) Cancer Research. 68: 338. DOI: 10.1158/0008-5472.CAN-68-1-COR  0.84
2007 Swanson BJ, McDermott KM, Singh PK, Eggers JP, Crocker PR, Hollingsworth MA. MUC1 is a counter-receptor for myelin-associated glycoprotein (Siglec-4a) and their interaction contributes to adhesion in pancreatic cancer perineural invasion. Cancer Research. 67: 10222-9. PMID 17974963 DOI: 10.1158/0008-5472.CAN-06-2483  0.84
2007 Bailey JM, Singh PK, Hollingsworth MA. Cancer metastasis facilitated by developmental pathways: Sonic hedgehog, Notch, and bone morphogenic proteins. Journal of Cellular Biochemistry. 102: 829-39. PMID 17914743 DOI: 10.1002/jcb.21509  0.84
2006 Singh PK, Hollingsworth MA. Cell surface-associated mucins in signal transduction. Trends in Cell Biology. 16: 467-76. PMID 16904320 DOI: 10.1016/j.tcb.2006.07.006  0.84
2006 Tsutsumida H, Swanson BJ, Singh PK, Caffrey TC, Kitajima S, Goto M, Yonezawa S, Hollingsworth MA. RNA interference suppression of MUC1 reduces the growth rate and metastatic phenotype of human pancreatic cancer cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 2976-87. PMID 16707592 DOI: 10.1158/1078-0432.CCR-05-1197  0.84
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