Christopher R. McCurdy - Publications

Medicinal Chemistry The University of Mississippi, USA 
Organic Chemistry, Pharmaceutical Chemistry

112 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Kamble SH, León F, King TI, Berthold EC, Lopera-Londoño C, Siva Rama Raju K, Hampson AJ, Sharma A, Avery BA, McMahon LR, McCurdy CR. Metabolism of a Kratom Alkaloid Metabolite in Human Plasma Increases Its Opioid Potency and Efficacy. Acs Pharmacology & Translational Science. 3: 1063-1068. PMID 33344889 DOI: 10.1021/acsptsci.0c00075  0.32
2020 Singh D, Brown PN, Cinosi E, Corazza O, Henningfield JE, Garcia-Romeu A, McCurdy CR, McMahon LR, Prozialeck WC, Smith KE, Swogger MT, Veltri C, Walsh Z, Grundmann O. Current and Future Potential Impact of COVID-19 on Kratom ( Korth.) Supply and Use. Frontiers in Psychiatry. 11: 574483. PMID 33324252 DOI: 10.3389/fpsyt.2020.574483  0.44
2020 Berthold EC, Kamble SH, Raju KS, King TI, Popa R, Sharma A, León F, Avery BA, McMahon LR, McCurdy CR. Preclinical pharmacokinetic study of speciociliatine, a kratom alkaloid, in rats using an UPLC-MS/MS method. Journal of Pharmaceutical and Biomedical Analysis. 113778. PMID 33277117 DOI: 10.1016/j.jpba.2020.113778  0.32
2020 Wilson LL, Harris HM, Eans SO, Brice-Tutt AC, Cirino TJ, Stacy HM, Simons CA, León F, Sharma A, Boyer EW, Avery BA, McLaughlin JP, McCurdy CR. Lyophilized Kratom Tea as a Therapeutic Option for Opioid Dependence. Drug and Alcohol Dependence. 216: 108310. PMID 33017752 DOI: 10.1016/j.drugalcdep.2020.108310  0.36
2020 Lepelletier FX, Vandesquille M, Asselin MC, Prenant C, Robinson AC, Mann DMA, Green M, Barnett E, Banister SD, Mottinelli M, Mesangeau C, McCurdy CR, Fricke IB, Jacobs AH, Kassiou M, et al. Evaluation of F-IAM6067 as a sigma-1 receptor PET tracer for neurodegeneration in rodents and in human tissue. Theranostics. 10: 7938-7955. PMID 32724451 DOI: 10.7150/thno.47585  0.52
2020 Maxwell EA, King TI, Kamble SH, Raju KSR, Berthold EC, León F, Avery BA, McMahon LR, McCurdy CR, Sharma A. Pharmacokinetics and Safety of Mitragynine in Beagle Dogs. Planta Medica. PMID 32693425 DOI: 10.1055/a-1212-5475  0.32
2020 Intagliata S, Sharma A, King TI, Mesangeau C, Seminerio M, Chin FT, Wilson LL, Matsumoto RR, McLaughlin JP, Avery BA, McCurdy CR. Discovery of a Highly Selective Sigma-2 Receptor Ligand, 1-(4-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-3-methyl-1H-benzo[d]imidazol-2(3H)-one (CM398), with Drug-Like Properties and Antinociceptive Effects In Vivo. The Aaps Journal. 22: 94. PMID 32691179 DOI: 10.1208/s12248-020-00472-x  0.52
2019 King TI, Sharma A, Kamble SH, León F, Berthold EC, Popa R, Cerlati O, Prentice BM, McMahon LR, McCurdy CR, Avery BA. Bioanalytical method development and validation of corynantheidine, a kratom alkaloid, using UPLC-MS/MS, and its application to preclinical pharmacokinetic studies. Journal of Pharmaceutical and Biomedical Analysis. 180: 113019. PMID 31838282 DOI: 10.1016/j.jpba.2019.113019  0.32
2019 Obeng S, Kamble SH, Reeves ME, Restrepo LF, Patel A, Behnke M, Chear N, Ramanathan S, Sharma A, Leon F, Hiranita T, Avery BA, McMahon LR, McCurdy CR. Investigation of the Adrenergic and Opioid Binding affinities, Metabolic Stability, Plasma Protein Binding Properties and Functional Effects of Selected Indole-based Kratom Alkaloids. Journal of Medicinal Chemistry. PMID 31834797 DOI: 10.1021/acs.jmedchem.9b01465  0.32
2019 Singh D, Yeou Chear NJ, Narayanan S, Leon F, Sharma A, McCurdy CR, Avery BA, Balasingam V. Patterns and reasons for kratom (Mitragyna speciosa) use among current and former opioid poly-drug users. Journal of Ethnopharmacology. 112462. PMID 31816368 DOI: 10.1016/j.jep.2019.112462  0.52
2019 King TI, Roewekamp AC, Sharma A, Harrison S, Mesangeau C, Mottinelli M, Kamble SH, McCurdy CR, Avery BA. Bioanalytical method development and validation of MES207, a neuropeptide FF receptor antagonist, and its application in preclinical pharmacokinetics. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 1134: 121875. PMID 31790916 DOI: 10.1016/j.jchromb.2019.121875  0.52
2019 Kamble SH, Sharma A, King T, Berthold EC, León F, Meyer PKL, Kanumuri SRR, McMahon LR, McCurdy CR, Avery BA. Exploration of Cytochrome P450 Inhibition Mediated Drug-Drug Interaction Potential of Kratom Alkaloids. Toxicology Letters. PMID 31707106 DOI: 10.1016/j.toxlet.2019.11.005  0.32
2019 Prozialeck WC, Avery BA, Boyer EW, Grundmann O, Henningfield JE, Kruegel AC, McMahon LR, McCurdy CR, Swogger MT, Veltri CA, Singh D. Kratom policy: The challenge of balancing therapeutic potential with public safety. The International Journal On Drug Policy. 70: 70-77. PMID 31103778 DOI: 10.1016/j.drugpo.2019.05.003  0.44
2019 Hiranita T, Leon F, Felix JS, Restrepo LF, Reeves ME, Pennington AE, Obeng S, Avery BA, McCurdy CR, McMahon LR, Wilkerson JL. The effects of mitragynine and morphine on schedule-controlled responding and antinociception in rats. Psychopharmacology. PMID 31098655 DOI: 10.1007/s00213-019-05247-7  0.32
2019 Sharma A, Kamble SH, León F, Chear NJ, King TI, Berthold EC, Ramanathan S, McCurdy CR, Avery BA. Simultaneous Quantification of Ten Key Kratom Alkaloids in Mitragyna speciosa Leaf Extracts and Commercial Products by Ultra-Performance Liquid Chromatography - Tandem Mass Spectrometry. Drug Testing and Analysis. PMID 30997725 DOI: 10.1002/dta.2604  0.32
2019 Intagliata S, Alsharif WF, Mesangeau C, Fazio N, Seminerio M, Xu YT, Matsumoto RR, McCurdy CR. Benzimidazolone-based selective σ receptor ligands: Synthesis and pharmacological evaluation. European Journal of Medicinal Chemistry. 165: 250-257. PMID 30685525 DOI: 10.1016/j.ejmech.2019.01.019  0.52
2018 Singh D, Narayanan S, Müller CP, Swogger MT, Chear NJY, Dzulkapli EB, Yusoff NSM, Ramachandram DS, León F, McCurdy CR, Vicknasingam B. Motives for Using Kratom (Mitragyna speciosa Korth.) among Regular Users in Malaysia. Journal of Ethnopharmacology. PMID 30594604 DOI: 10.1016/j.jep.2018.12.038  0.52
2018 Kamble SH, Sharma A, King TI, León F, McCurdy CR, Avery BA. Metabolite profiling and identification of enzymes responsible for the metabolism of mitragynine, the major alkaloid of Mitragyna speciosa (kratom). Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 1-31. PMID 30547698 DOI: 10.1080/00498254.2018.1552819  0.32
2018 Nicholson HE, Alsharif WF, Comeau AB, Mesangeau C, Intagliata S, Mottinelli M, McCurdy CR, Bowen WD. Divergent Cytotoxic and Metabolically Stimulative Functions of Sigma-2 Receptors: Structure-activity Relationships of 6-acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79) Derivatives. The Journal of Pharmacology and Experimental Therapeutics. PMID 30530624 DOI: 10.1124/jpet.118.253484  0.52
2018 Avery BA, Boddu SP, Sharma A, Furr EB, Leon F, Cutler SJ, McCurdy CR. Comparative Pharmacokinetics of Mitragynine after Oral Administration of Mitragyna speciosa (Kratom) Leaf Extracts in Rats. Planta Medica. PMID 30452072 DOI: 10.1055/a-0770-3683  0.32
2017 Shen B, Park JH, Hjørnevik T, Cipriano PW, Yoon D, Gulaka PK, Holly D, Behera D, Avery BA, Gambhir SS, McCurdy CR, Biswal S, Chin FT. Radiosynthesis and First-In-Human PET/MRI Evaluation with Clinical-Grade [(18)F]FTC-146. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. PMID 28280965 DOI: 10.1007/s11307-017-1064-z  0.32
2016 Avery BA, Vuppala PK, Jamalapuram S, Sharma A, Mesangeau C, Chin FT, McCurdy CR. Quantification of Highly Selective Sigma-1 Receptor Antagonist CM304 using Liquid Chromatography Tandem Mass Spectrometry and its application to a Pre-clinical Pharmacokinetic Study. Drug Testing and Analysis. PMID 28039926 DOI: 10.1002/dta.2156  0.52
2016 Lydecker AG, Sharma A, McCurdy CR, Avery BA, Babu KM, Boyer EW. Suspected Adulteration of Commercial Kratom Products with 7-Hydroxymitragynine. Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology. PMID 27752985 DOI: 10.1007/s13181-016-0588-y  1
2016 Katz JL, Hiranita T, Kopajtic TA, Rice KC, Mesangeau C, Narayanan S, Abdelazeem AH, McCurdy CR. Blockade of Cocaine or Sigma Receptor Agonist Self-Administration by Subtype- Selective Sigma Receptor Antagonists. The Journal of Pharmacology and Experimental Therapeutics. PMID 27189970 DOI: 10.1124/jpet.116.232728  1
2015 Chu UB, Mavlyutov TA, Chu ML, Yang H, Schulman A, Mesangeau C, McCurdy CR, Guo LW, Ruoho AE. The Sigma-2 Receptor and Progesterone Receptor Membrane Component 1 are Different Binding Sites Derived From Independent Genes. Ebiomedicine. 2: 1806-13. PMID 26870805 DOI: 10.1016/j.ebiom.2015.10.017  1
2015 Nicholson H, Mesangeau C, McCurdy CR, Bowen WD. Sigma-2 receptors play a role in cellular metabolism: Stimulation of glycolytic hallmarks by CM764 in human SK-N-SH neuroblastoma. The Journal of Pharmacology and Experimental Therapeutics. PMID 26574517 DOI: 10.1124/jpet.115.228387  1
2015 Shen B, James ML, Andrews L, Lau C, Chen S, Palner M, Miao Z, Arksey NC, Shuhendler AJ, Scatliffe S, Kaneshige K, Parsons SM, McCurdy CR, Salehi A, Gambhir SS, et al. Further validation to support clinical translation of [(18)F]FTC-146 for imaging sigma-1 receptors. Ejnmmi Research. 5: 49. PMID 26384292 DOI: 10.1186/s13550-015-0122-2  1
2015 Kumarihamy M, León F, Pettaway S, Wilson L, Lambert JA, Wang M, Hill C, McCurdy CR, ElSohly MA, Cutler SJ, Muhammad I. In vitro opioid receptor affinity and in vivo behavioral studies of Nelumbo nucifera flower. Journal of Ethnopharmacology. JEPD1501341. PMID 26260436 DOI: 10.1016/j.jep.2015.08.006  1
2015 Nicholson H, Comeau A, Mesangeau C, McCurdy CR, Bowen WD. Characterization of CM572, a Selective Irreversible Partial Agonist of the Sigma-2 Receptor with Antitumor Activity. The Journal of Pharmacology and Experimental Therapeutics. 354: 203-12. PMID 26034081 DOI: 10.1124/jpet.115.224105  1
2015 Abdelazeem AH, Khan SI, White SW, Sufka KJ, McCurdy CR. Design, synthesis and biological evaluation of bivalent benzoxazolone and benzothiazolone ligands as potential anti-inflammatory/analgesic agents. Bioorganic & Medicinal Chemistry. 23: 3248-59. PMID 25975638 DOI: 10.1016/j.bmc.2015.04.057  1
2014 Husni AS, McCurdy CR, Radwan MM, Ahmed SA, Slade D, Ross SA, ElSohly MA, Cutler SJ. Evaluation of Phytocannabinoids from High Potency Cannabis sativa using In Vitro Bioassays to Determine Structure-Activity Relationships for Cannabinoid Receptor 1 and Cannabinoid Receptor 2. Medicinal Chemistry Research : An International Journal For Rapid Communications On Design and Mechanisms of Action of Biologically Active Agents. 23: 4295-4300. PMID 25419092 DOI: 10.1007/s00044-014-0972-6  1
2014 Journigan VB, Mésangeau C, Vyas N, Eans SO, Cutler SJ, McLaughlin JP, Mollereau C, McCurdy CR. Nonpeptide small molecule agonist and antagonist original leads for neuropeptide FF1 and FF2 receptors. Journal of Medicinal Chemistry. 57: 8903-27. PMID 25268943 DOI: 10.1021/jm500989n  1
2014 Tarawneh AH, León F, Ibrahim MA, Pettaway S, McCurdy CR, Cutler SJ. Flavanones from Miconia prasina. Phytochemistry Letters. 7: 130-132. PMID 24976876 DOI: 10.1016/j.phytol.2013.11.001  1
2014 Abdelazeem AH, Abdelatef SA, El-Saadi MT, Omar HA, Khan SI, McCurdy CR, El-Moghazy SM. Novel pyrazolopyrimidine derivatives targeting COXs and iNOS enzymes; design, synthesis and biological evaluation as potential anti-inflammatory agents. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 62: 197-211. PMID 24907682 DOI: 10.1016/j.ejps.2014.05.025  1
2014 Robson MJ, Turner RC, Naser ZJ, McCurdy CR, O'Callaghan JP, Huber JD, Matsumoto RR. SN79, a sigma receptor antagonist, attenuates methamphetamine-induced astrogliosis through a blockade of OSMR/gp130 signaling and STAT3 phosphorylation. Experimental Neurology. 254: 180-9. PMID 24508558 DOI: 10.1016/j.expneurol.2014.01.020  1
2014 Kaushal N, Robson MJ, Rosen A, McCurdy CR, Matsumoto RR. Neuroprotective targets through which 6-acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79), a sigma receptor ligand, mitigates the effects of methamphetamine in vitro. European Journal of Pharmacology. 724: 193-203. PMID 24380829 DOI: 10.1016/j.ejphar.2013.12.039  1
2014 James ML, Shen B, Nielsen CH, Behera D, Buckmaster CL, Mesangeau C, Zavaleta C, Vuppala PK, Jamalapuram S, Avery BA, Lyons DM, McCurdy CR, Biswal S, Gambhir SS, Chin FT. Evaluation of σ-1 receptor radioligand 18F-FTC-146 in rats and squirrel monkeys using PET. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 55: 147-53. PMID 24337599 DOI: 10.2967/jnumed.113.120261  1
2013 Vuppala PK, Jamalapuram S, Furr EB, McCurdy CR, Avery BA. Development and validation of a UPLC-MS/MS method for the determination of 7-hydroxymitragynine, a μ-opioid agonist, in rat plasma and its application to a pharmacokinetic study. Biomedical Chromatography : Bmc. 27: 1726-32. PMID 23893615 DOI: 10.1002/bmc.2986  1
2013 Gregg RA, Tallarida CS, Reitz A, McCurdy C, Rawls SM. Mephedrone (4-methylmethcathinone), a principal constituent of psychoactive bath salts, produces behavioral sensitization in rats. Drug and Alcohol Dependence. 133: 746-50. PMID 23890492 DOI: 10.1016/j.drugalcdep.2013.06.014  1
2013 Bhat R, Fishback JA, Matsumoto RR, Poupaert JH, McCurdy CR. Structure activity relationship study of benzo[d]thiazol-2(3H)one based σ receptor ligands. Bioorganic & Medicinal Chemistry Letters. 23: 5011-3. PMID 23867168 DOI: 10.1016/j.bmcl.2013.06.032  1
2013 Robson MJ, Seminerio MJ, McCurdy CR, Coop A, Matsumoto RR. σ Receptor antagonist attenuation of methamphetamine-induced neurotoxicity is correlated to body temperature modulation. Pharmacological Reports : Pr. 65: 343-9. PMID 23744418  1
2013 Robson MJ, Turner RC, Naser ZJ, McCurdy CR, Huber JD, Matsumoto RR. SN79, a sigma receptor ligand, blocks methamphetamine-induced microglial activation and cytokine upregulation. Experimental Neurology. 247: 134-42. PMID 23631864 DOI: 10.1016/j.expneurol.2013.04.009  1
2013 Jamalapuram S, Vuppala PK, Abdelazeem AH, McCurdy CR, Avery BA. Ultra-performance liquid chromatography tandem mass spectrometry method for the determination of AZ66, a sigma receptor ligand, in rat plasma and its application to in vivo pharmacokinetics. Biomedical Chromatography : Bmc. 27: 1034-40. PMID 23558564 DOI: 10.1002/bmc.2901  1
2013 Giacometti RD, Duchek J, Werner L, Husni AS, McCurdy CR, Cutler SJ, Cox DP, Hudlicky T. Heteroatom analogues of hydrocodone: synthesis and biological activity. The Journal of Organic Chemistry. 78: 2914-25. PMID 23397939 DOI: 10.1021/jo3026753  1
2013 Seminerio MJ, Hansen R, Kaushal N, Zhang HT, McCurdy CR, Matsumoto RR. The evaluation of AZ66, an optimized sigma receptor antagonist, against methamphetamine-induced dopaminergic neurotoxicity and memory impairment in mice. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 16: 1033-44. PMID 22932447 DOI: 10.1017/S1461145712000831  1
2013 Kaushal N, Seminerio MJ, Robson MJ, McCurdy CR, Matsumoto RR. Pharmacological evaluation of SN79, a sigma (σ) receptor ligand, against methamphetamine-induced neurotoxicity in vivo. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 23: 960-71. PMID 22921523 DOI: 10.1016/j.euroneuro.2012.08.005  1
2013 Poupaert JH, Gbaguidi FA, Kapanda CN, Aichaoui H, McCurdy CR. Is cocaine a social drug? Exploration of the stereo-structure of cocaine's pharmacophore Medicinal Chemistry Research. 22: 247-252. DOI: 10.1007/s00044-012-0005-2  1
2012 Harden MT, Smith SE, Niehoff JA, McCurdy CR, Taylor GT. Antidepressive effects of the κ-opioid receptor agonist salvinorin A in a rat model of anhedonia. Behavioural Pharmacology. 23: 710-5. PMID 22926298 DOI: 10.1097/FBP.0b013e3283586189  1
2012 Fishback JA, Rosen A, Bhat R, McCurdy CR, Matsumoto RR. A 96-well filtration method for radioligand binding analysis of σ receptor ligands. Journal of Pharmaceutical and Biomedical Analysis. 71: 157-61. PMID 22910107 DOI: 10.1016/j.jpba.2012.07.023  1
2012 James ML, Shen B, Zavaleta CL, Nielsen CH, Mesangeau C, Vuppala PK, Chan C, Avery BA, Fishback JA, Matsumoto RR, Gambhir SS, McCurdy CR, Chin FT. New positron emission tomography (PET) radioligand for imaging σ-1 receptors in living subjects. Journal of Medicinal Chemistry. 55: 8272-82. PMID 22853801 DOI: 10.1021/jm300371c  1
2012 Seminerio MJ, Robson MJ, McCurdy CR, Matsumoto RR. Sigma receptor antagonists attenuate acute methamphetamine-induced hyperthermia by a mechanism independent of IL-1β mRNA expression in the hypothalamus. European Journal of Pharmacology. 691: 103-9. PMID 22820108 DOI: 10.1016/j.ejphar.2012.07.029  1
2012 Mankus JV, McCurdy CR. Nonpeptide ligands of neuropeptide FF: current status and structural insights. Future Medicinal Chemistry. 4: 1085-92. PMID 22709252 DOI: 10.4155/fmc.12.67  1
2012 Nieto MJ, Pierini AB, Singh N, McCurdy CR, Manzo RH, Mazzieri MR. SAR analysis of new dual targeting fluoroquinolones. Implications of the benzenesulfonyl group. Medicinal Chemistry (ShāRiqah (United Arab Emirates)). 8: 349-60. PMID 22530906 DOI: 10.2174/157340612800786633  1
2012 Jamalapuram S, Vuppala PK, Mesangeau C, McCurdy CR, Avery BA. Determination of a highly selective mixed-affinity sigma receptor ligand, in rat plasma by ultra performance liquid chromatography mass spectrometry and its application to a pharmacokinetic study. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 891: 1-6. PMID 22406103 DOI: 10.1016/j.jchromb.2011.12.013  1
2012 Xu YT, Robson MJ, Szeszel-Fedorowicz W, Patel D, Rooney R, McCurdy CR, Matsumoto RR. CM156, a sigma receptor ligand, reverses cocaine-induced place conditioning and transcriptional responses in the brain. Pharmacology, Biochemistry, and Behavior. 101: 174-80. PMID 22234290 DOI: 10.1016/j.pbb.2011.12.016  1
2012 Seminerio MJ, Robson MJ, Abdelazeem AH, Mesangeau C, Jamalapuram S, Avery BA, McCurdy CR, Matsumoto RR. Synthesis and pharmacological characterization of a novel sigma receptor ligand with improved metabolic stability and antagonistic effects against methamphetamine. The Aaps Journal. 14: 43-51. PMID 22183188 DOI: 10.1208/s12248-011-9311-8  1
2011 Ward J, Rosenbaum C, Hernon C, McCurdy CR, Boyer EW. Herbal medicines for the management of opioid addiction: safe and effective alternatives to conventional pharmacotherapy? Cns Drugs. 25: 999-1007. PMID 22133323 DOI: 10.2165/11596830-000000000-00000  1
2011 Mésangeau C, Amata E, Alsharif W, Seminerio MJ, Robson MJ, Matsumoto RR, Poupaert JH, McCurdy CR. Synthesis and pharmacological evaluation of indole-based sigma receptor ligands. European Journal of Medicinal Chemistry. 46: 5154-61. PMID 21899931 DOI: 10.1016/j.ejmech.2011.08.031  1
2011 Kaushal N, Seminerio MJ, Shaikh J, Medina MA, Mesangeau C, Wilson LL, McCurdy CR, Matsumoto RR. CM156, a high affinity sigma ligand, attenuates the stimulant and neurotoxic effects of methamphetamine in mice. Neuropharmacology. 61: 992-1000. PMID 21762711 DOI: 10.1016/j.neuropharm.2011.06.028  1
2011 McCurdy CR. Strategies to treat substance abuse and addiction. Current Topics in Medicinal Chemistry. 11: 1102. PMID 21506917 DOI: 10.2174/156802611795371297  1
2011 Kaushal N, Robson MJ, Vinnakota H, Narayanan S, Avery BA, McCurdy CR, Matsumoto RR. Synthesis and pharmacological evaluation of 6-acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79), a cocaine antagonist, in rodents. The Aaps Journal. 13: 336-46. PMID 21494909 DOI: 10.1208/s12248-011-9274-9  1
2011 Narayanan S, Bhat R, Mesangeau C, Poupaert JH, McCurdy CR. Early development of sigma-receptor ligands. Future Medicinal Chemistry. 3: 79-94. PMID 21428827 DOI: 10.4155/fmc.10.279  1
2011 Yekkirala AS, Lunzer MM, McCurdy CR, Powers MD, Kalyuzhny AE, Roerig SC, Portoghese PS. N-naphthoyl-beta-naltrexamine (NNTA), a highly selective and potent activator of μ/kappa-opioid heteromers. Proceedings of the National Academy of Sciences of the United States of America. 108: 5098-103. PMID 21385944 DOI: 10.1073/pnas.1016277108  1
2011 Chajkowski SM, Mallela J, Watson DE, Wang J, McCurdy CR, Rimoldi JM, Shariat-Madar Z. Highly selective hydrolysis of kinins by recombinant prolylcarboxypeptidase. Biochemical and Biophysical Research Communications. 405: 338-43. PMID 21167814 DOI: 10.1016/j.bbrc.2010.12.036  1
2011 Fishback JA, Mesangeau C, Poupaert JH, McCurdy CR, Matsumoto RR. Synthesis and characterization of [³H]-SN56, a novel radioligand for the σ₁ receptor. European Journal of Pharmacology. 653: 1-7. PMID 21130085 DOI: 10.1016/j.ejphar.2010.10.099  1
2011 Narayanan S, Mesangeau C, Poupaert JH, McCurdy CR. Sigma receptors and cocaine abuse. Current Topics in Medicinal Chemistry. 11: 1128-50. PMID 21050176 DOI: 10.2174/156802611795371323  1
2011 Adkins JE, Boyer EW, McCurdy CR. Mitragyna speciosa, a psychoactive tree from Southeast Asia with opioid activity. Current Topics in Medicinal Chemistry. 11: 1165-75. PMID 21050173 DOI: 10.2174/156802611795371305  1
2011 Garcés-Ramírez L, Green JL, Hiranita T, Kopajtic TA, Mereu M, Thomas AM, Mesangeau C, Narayanan S, McCurdy CR, Katz JL, Tanda G. Sigma receptor agonists: receptor binding and effects on mesolimbic dopamine neurotransmission assessed by microdialysis. Biological Psychiatry. 69: 208-17. PMID 20950794 DOI: 10.1016/j.biopsych.2010.07.026  1
2011 Vuppala PK, Boddu SP, Furr EB, McCurdy CR, Avery BA. Simple, sensitive, high-throughput method for the quantification of mitragynine in rat plasma using UPLC-MS and its application to an intravenous pharmacokinetic study Chromatographia. 74: 703-710. DOI: 10.1007/s10337-011-2128-x  1
2011 Guenadil F, Aichaoui H, Kapanda CN, Lambert DM, McCurdy CR, Poupaert JH. Design and synthesis of 3-acyl-2(3H)-benzoxazolone and 3-acyl-2(3H)- benzothiazolone derivatives Monatshefte Fur Chemie. 142: 67-80. DOI: 10.1007/s00706-010-0419-9  1
2010 Liu H, McCurdy CR, Doerksen RJ. Computational Study on the Conformations of Mitragynine and Mitragynaline. Theochem. 945: 57-63. PMID 21293786 DOI: 10.1016/j.theochem.2010.01.011  1
2010 Xu YT, Kaushal N, Shaikh J, Wilson LL, Mésangeau C, McCurdy CR, Matsumoto RR. A novel substituted piperazine, CM156, attenuates the stimulant and toxic effects of cocaine in mice. The Journal of Pharmacology and Experimental Therapeutics. 333: 491-500. PMID 20100904 DOI: 10.1124/jpet.109.161398  1
2009 Nolan T, Singh N, McCurdy CR. Ligand macromolecule interactions: theoretical principles of molecular recognition. Methods in Molecular Biology (Clifton, N.J.). 572: 13-29. PMID 20694683 DOI: 10.1007/978-1-60761-244-5_2  1
2009 León F, Habib E, Adkins JE, Furr EB, McCurdy CR, Cutler SJ. Phytochemical characterization of the leaves of Mitragyna speciosa grown in U.S.A. Natural Product Communications. 4: 907-10. PMID 19731590  1
2009 de Moraes NV, Moretti RA, Furr EB, McCurdy CR, Lanchote VL. Determination of mitragynine in rat plasma by LC-MS/MS: application to pharmacokinetics. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 877: 2593-7. PMID 19589735 DOI: 10.1016/j.jchromb.2009.06.023  1
2009 Dayan FE, Singh N, McCurdy CR, Godfrey CA, Larsen L, Weavers RT, Van Klink JW, Perry NB. Beta-triketone inhibitors of plant p-hydroxyphenylpyruvate dioxygenase: modeling and comparative molecular field analysis of their interactions. Journal of Agricultural and Food Chemistry. 57: 5194-200. PMID 19435355 DOI: 10.1021/jf9005593  1
2009 Guenadil F, Aichaoui H, Lambert DM, McCurdy CR, Poupaert JH. Highly selective catalytic friedel-crafts acylation of activated aromatic compounds using the I 2. DMF complex as catalyst Letters in Organic Chemistry. 5: 665-668. DOI: 10.2174/157017808786857624  1
2009 Aichaoui H, Guenadil F, Kapanda CN, Lambert DM, McCurdy CR, Poupaert JH. Synthesis and pharmacological evaluation of antioxidant chalcone derivatives of 2(3H)-benzoxazolones Medicinal Chemistry Research. 18: 467-476. DOI: 10.1007/s00044-008-9143-y  1
2008 Boyer EW, Babu KM, Adkins JE, McCurdy CR, Halpern JH. Self-treatment of opioid withdrawal using kratom (Mitragynia speciosa korth). Addiction (Abingdon, England). 103: 1048-50. PMID 18482427 DOI: 10.1111/j.1360-0443.2008.02209.x  1
2008 Singh N, Nolan TL, McCurdy CR. Chemical function-based pharmacophore development for novel, selective kappa opioid receptor agonists. Journal of Molecular Graphics & Modelling. 27: 131-9. PMID 18456526 DOI: 10.1016/j.jmgm.2008.03.007  1
2008 Kane BE, McCurdy CR, Ferguson DM. Toward a structure-based model of salvinorin A recognition of the kappa-opioid receptor. Journal of Medicinal Chemistry. 51: 1824-30. PMID 18293909 DOI: 10.1021/jm701040v  1
2008 Mésangeau C, Narayanan S, Green AM, Shaikh J, Kaushal N, Viard E, Xu YT, Fishback JA, Poupaert JH, Matsumoto RR, McCurdy CR. Conversion of a highly selective sigma-1 receptor-ligand to sigma-2 receptor preferring ligands with anticocaine activity. Journal of Medicinal Chemistry. 51: 1482-6. PMID 18278854 DOI: 10.1021/jm701357m  1
2008 Babu KM, McCurdy CR, Boyer EW. Opioid receptors and legal highs: Salvia divinorum and Kratom. Clinical Toxicology (Philadelphia, Pa.). 46: 146-52. PMID 18259963 DOI: 10.1080/15563650701241795  1
2007 Singh N, Avery MA, McCurdy CR. Toward Mycobacterium tuberculosis DXR inhibitor design: homology modeling and molecular dynamics simulations. Journal of Computer-Aided Molecular Design. 21: 511-22. PMID 17874041 DOI: 10.1007/s10822-007-9132-0  1
2007 Willmore-Fordham CB, Krall DM, McCurdy CR, Kinder DH. The hallucinogen derived from Salvia divinorum, salvinorin A, has kappa-opioid agonist discriminative stimulus effects in rats. Neuropharmacology. 53: 481-6. PMID 17681558 DOI: 10.1016/j.neuropharm.2007.06.008  1
2007 Haris SP, Zhang Y, Le Bourdonnec B, McCurdy CR, Portoghese PS. o-Naphthalenedicarboxaldehyde derivative of 7'-aminonaltrindole as a selective delta-opioid receptor affinity label. Journal of Medicinal Chemistry. 50: 3392-6. PMID 17555306 DOI: 10.1021/jm061194h  1
2007 Singh N, Chevé G, Avery MA, McCurdy CR. Targeting the methyl erythritol phosphate (MEP) pathway for novel antimalarial, antibacterial and herbicidal drug discovery: inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) enzyme. Current Pharmaceutical Design. 13: 1161-77. PMID 17430177 DOI: 10.2174/138161207780618939  1
2007 Dayan FE, Duke SO, Sauldubois A, Singh N, McCurdy C, Cantrell C. p-Hydroxyphenylpyruvate dioxygenase is a herbicidal target site for beta-triketones from Leptospermum scoparium. Phytochemistry. 68: 2004-14. PMID 17368492 DOI: 10.1016/j.phytochem.2007.01.026  0.68
2007 Philip AE, Poupaert JH, Chevé G, Muccioli G, Lambert D, McCurdy CR. Structure-activity relationship of phenytoinergic antiepileptic drugs related to ameltolide Medicinal Chemistry Research. 16: 130-135. DOI: 10.1007/s00044-007-9016-9  1
2007 Martinez MN, Bonate P, Chapman RL, De Groot A, D'Souza S, Ghilazi N, Gray V, Gupta VK, Huynh-Ba K, Iyer S, Jayatilaka A, Joshi A, Karnes HT, Khan M, Liu P, ... ... McCurdy CR, et al. 2007 highlights of advance in the pharmaceutical sciences: An American Association of Pharmaceutical Scientists (AAPS) perspective Aaps Journal. 9.  1
2006 Singh N, Chevé G, Ferguson DM, McCurdy CR. A combined ligand-based and target-based drug design approach for G-protein coupled receptors: application to salvinorin A, a selective kappa opioid receptor agonist. Journal of Computer-Aided Molecular Design. 20: 471-93. PMID 17009091 DOI: 10.1007/s10822-006-9067-x  1
2006 Singh N, Chevé G, Avery MA, McCurdy CR. Comparative protein modeling of 1-deoxy-D-xylulose-5-phosphate reductoisomerase enzyme from Plasmodium falciparum: a potential target for antimalarial drug discovery. Journal of Chemical Information and Modeling. 46: 1360-70. PMID 16711755 DOI: 10.1021/ci050523w  1
2006 Kane BE, Nieto MJ, McCurdy CR, Ferguson DM. A unique binding epitope for salvinorin A, a non-nitrogenous kappa opioid receptor agonist. The Febs Journal. 273: 1966-74. PMID 16640560 DOI: 10.1111/j.1742-4658.2006.05212.x  1
2006 Vyas N, Mollereau C, Chevé G, McCurdy CR. Structure-activity relationships of neuropeptide FF and related peptidic and non-peptidic derivatives. Peptides. 27: 990-6. PMID 16490282 DOI: 10.1016/j.peptides.2005.07.024  1
2006 McCurdy CR, Sufka KJ, Smith GH, Warnick JE, Nieto MJ. Antinociceptive profile of salvinorin A, a structurally unique kappa opioid receptor agonist. Pharmacology, Biochemistry, and Behavior. 83: 109-13. PMID 16434091 DOI: 10.1016/j.pbb.2005.12.011  1
2006 McCurdy CR. Development of Opioid Receptor Ligands Analogue-Based Drug Discovery. 259-276. DOI: 10.1002/3527608001.ch14  1
2005 McCurdy CR, Scully SS. Analgesic substances derived from natural products (natureceuticals). Life Sciences. 78: 476-84. PMID 16216276 DOI: 10.1016/j.lfs.2005.09.006  1
2005 Geldenhuys WJ, Lockman PR, Philip AE, McAfee JH, Miller BL, McCurdy CR, Allen DD. Inhibition of choline uptake by N-cyclohexylcholine, a high affinity ligand for the choline transporter at the blood-brain barrier. Journal of Drug Targeting. 13: 259-66. PMID 16051538 DOI: 10.1080/10611860500139222  1
2005 Warnick JE, McCurdy CR, Sufka KJ. Opioid receptor function in social attachment in young domestic fowl. Behavioural Brain Research. 160: 277-85. PMID 15863224 DOI: 10.1016/j.bbr.2004.12.009  1
2005 Philip AE, Poupaert JH, McCurdy CR. Opioid receptor-like 1 (ORL1) molecular "road map" to understanding ligand interaction and selectivity. Current Topics in Medicinal Chemistry. 5: 325-40. PMID 15857315 DOI: 10.2174/1568026053544489  1
2005 Nieto MJ, Philip AE, Poupaert JH, McCurdy CR. Solution-phase parallel synthesis of spirohydantoins. Journal of Combinatorial Chemistry. 7: 258-63. PMID 15762754 DOI: 10.1021/cc049870t  1
2005 Zhang Y, McCurdy CR, Metzger TG, Portoghese PS. Specific cross-linking of Lys233 and Cys235 in the mu opioid receptor by a reporter affinity label. Biochemistry. 44: 2271-5. PMID 15709739 DOI: 10.1021/bi048049v  1
2005 Poupaert JH, Carato P, McCurdy CR. A simple and effective method for the thionation of amides to thioamides using Al2O3-supported P4S10 Letters in Organic Chemistry. 2: 330-333. DOI: 10.2174/1570178054038957  1
2005 Yous S, Wallez V, Belloir M, Caignard DH, McCurdy CR, Poupaert JH. Novel 2(3H)-benzothiazolones as highly potent and selective sigma-1 receptor ligands Medicinal Chemistry Research. 14: 158-168. DOI: 10.1007/s00044-005-0131-1  1
2004 Poupaert JH, Duarte S, Colacino E, Depreux P, McCurdy CR, Lambert DL. Willgerodt-kindler's microwave-enhanced synthesis of thioamide derivatives Phosphorus, Sulfur and Silicon and the Related Elements. 179: 1959-1973. DOI: 10.1080/10426500490466995  1
2003 Poupaert JH, Depreux P, McCurdy CR. Unsymmetrical Diarylketones from Electron-rich Heterocyclic Arenes Monatshefte Fur Chemie. 134: 823-830. DOI: 10.1007/s00706-002-0573-9  1
2002 McCurdy CR, Le Bourdonnec B, Metzger TG, El Kouhen R, Zhang Y, Law PY, Portoghese PS. Naphthalene dicarboxaldehyde as an electrophilic fluorogenic moiety for affinity labeling: application to opioid receptor affinity labels with greatly improved fluorogenic properties. Journal of Medicinal Chemistry. 45: 2887-90. PMID 12086475 DOI: 10.1021/jm015586u  1
2000 McCurdy CR, Jones RM, Portoghese PS. Investigation of phenolic bioisosterism in opiates: 3-sulfonamido analogues of naltrexone and oxymorphone. Organic Letters. 2: 819-21. PMID 10754685  1
1999 McCurdy CR, Venkateshwaran TG, Beach JW, Stewart JT. Chiral separation of lobeline analogs using high performance capillary electrophoresis and derivatized cyclodextrins as chiral additives. Electrophoresis. 20: 212-8. PMID 10065979 DOI: 10.1002/(SICI)1522-2683(19990101)20:1<212::AID-ELPS212>3.0.CO;2-M  1
1998 Metting TL, Burgio DE, Terry AV, Beach JW, McCurdy CR, Allen DD. Inhibition of brain choline uptake by isoarecolone and lobeline derivatives: Implications for potential vector-mediated brain drug delivery Neuroscience Letters. 258: 25-28. PMID 9876043 DOI: 10.1016/S0304-3940(98)00871-4  1
1998 Terry AV, Williamson R, Gattu M, Beach JW, McCurdy CR, Sparks JA, Pauly JR. Lobeline and structurally simplified analogs exhibit differential agonist activity and sensitivity to antagonist blockade when compared to nicotine. Neuropharmacology. 37: 93-102. PMID 9680262 DOI: 10.1016/S0028-3908(97)00142-1  1
1997 Beach JW, McCurdy CR, Gattu M, Boss KL, Templeton RE, Terry AV. Synthesis and receptor binding of N-substituted-2-styryl-1,2,3,6-tetrahydropyridines as potential nicotinic agonists Medicinal Chemistry Research. 7: 271-281.  1
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