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Jonathan M. Backer - Publications

Yeshiva University, New York, NY, United States 
Cell Biology, Biochemistry

130 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Houslay DM, Anderson KE, Chessa T, Kulkarni S, Fritsch R, Downward J, Backer JM, Stephens LR, Hawkins PT. Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells. Science Signaling. 9: ra82. PMID 27531651 DOI: 10.1126/Scisignal.Aae0453  1
2015 LoPiccolo J, Kim SJ, Shi Y, Wu B, Wu H, Chait BT, Singer RH, Sali A, Brenowitz M, Bresnick AR, Backer JM. Assembly and Molecular Architecture of the Phosphoinositide 3-Kinase p85α Homodimer. The Journal of Biological Chemistry. PMID 26475863 DOI: 10.1074/Jbc.M115.689604  1
2015 Braccini L, Ciraolo E, Campa CC, Perino A, Longo DL, Tibolla G, Pregnolato M, Cao Y, Tassone B, Damilano F, Laffargue M, Calautti E, Falasca M, Norata GD, Backer JM, et al. PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling. Nature Communications. 6: 7400. PMID 26100075 DOI: 10.1038/Ncomms8400  1
2015 Jeschke A, Zehethofer N, Lindner B, Krupp J, Schwudke D, Haneburger I, Jovic M, Backer JM, Balla T, Hilbi H, Haas A. Phosphatidylinositol 4-phosphate and phosphatidylinositol 3-phosphate regulate phagolysosome biogenesis. Proceedings of the National Academy of Sciences of the United States of America. 112: 4636-41. PMID 25825728 DOI: 10.1073/Pnas.1423456112  1
2015 Salamon RS, Dbouk HA, Collado D, Lopiccolo J, Bresnick AR, Backer JM. Identification of the Rab5 binding site in p110β: assays for PI3Kβ binding to Rab5. Methods in Molecular Biology (Clifton, N.J.). 1298: 271-81. PMID 25800850 DOI: 10.1007/978-1-4939-2569-8_23  1
2014 Shemesh A, Wang Y, Yang Y, Yang GS, Johnson DE, Backer JM, Pessin JE, Zong H. Suppression of mTORC1 activation in acid-α-glucosidase-deficient cells and mice is ameliorated by leucine supplementation. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 307: R1251-9. PMID 25231351 DOI: 10.1152/Ajpregu.00212.2014  1
2014 Cao Y, Wang Y, Abi Saab WF, Yang F, Pessin JE, Backer JM. NRBF2 regulates macroautophagy as a component of Vps34 Complex I. The Biochemical Journal. 461: 315-22. PMID 24785657 DOI: 10.1042/Bj20140515  1
2013 Vadas O, Dbouk HA, Shymanets A, Perisic O, Burke JE, Abi Saab WF, Khalil BD, Harteneck C, Bresnick AR, Nürnberg B, Backer JM, Williams RL. Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs). Proceedings of the National Academy of Sciences of the United States of America. 110: 18862-7. PMID 24190998 DOI: 10.1073/Pnas.1304801110  1
2013 Salamon RS, Backer JM. Phosphatidylinositol-3,4,5-trisphosphate: tool of choice for class I PI 3-kinases. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 35: 602-11. PMID 23765576 DOI: 10.1002/Bies.201200176  1
2013 Dbouk HA, Khalil BD, Wu H, Shymanets A, Nürnberg B, Backer JM. Characterization of a tumor-associated activating mutation of the p110β PI 3-kinase. Plos One. 8: e63833. PMID 23734178 DOI: 10.1371/Journal.Pone.0063833  1
2013 Dou Z, Pan JA, Dbouk HA, Ballou LM, DeLeon JL, Fan Y, Chen JS, Liang Z, Li G, Backer JM, Lin RZ, Zong WX. Class IA PI3K p110β subunit promotes autophagy through Rab5 small GTPase in response to growth factor limitation. Molecular Cell. 50: 29-42. PMID 23434372 DOI: 10.1016/J.Molcel.2013.01.022  1
2013 Dbouk HA, Backer JM. Novel approaches to inhibitor design for the p110β phosphoinositide 3-kinase. Trends in Pharmacological Sciences. 34: 149-53. PMID 23411347 DOI: 10.1016/J.Tips.2012.12.004  1
2012 Dbouk HA, Vadas O, Williams RL, Backer JM. PI3Kβ downstream of GPCRs - crucial partners in oncogenesis. Oncotarget. 3: 1485-6. PMID 23328076 DOI: 10.18632/Oncotarget.787  1
2012 Dbouk HA, Vadas O, Shymanets A, Burke JE, Salamon RS, Khalil BD, Barrett MO, Waldo GL, Surve C, Hsueh C, Perisic O, Harteneck C, Shepherd PR, Harden TK, Smrcka AV, ... ... Backer JM, et al. G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness. Science Signaling. 5: ra89. PMID 23211529 DOI: 10.1126/Scisignal.2003264  1
2012 Smirnova T, Zhou ZN, Flinn RJ, Wyckoff J, Boimel PJ, Pozzuto M, Coniglio SJ, Backer JM, Bresnick AR, Condeelis JS, Hynes NE, Segall JE. Phosphoinositide 3-kinase signaling is critical for ErbB3-driven breast cancer cell motility and metastasis. Oncogene. 31: 706-15. PMID 21725367 DOI: 10.1038/Onc.2011.275  1
2011 Cai X, Srivastava S, Sun Y, Li Z, Wu H, Zuvela-Jelaska L, Li J, Salamon RS, Backer JM, Skolnik EY. Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2β. Proceedings of the National Academy of Sciences of the United States of America. 108: 20072-7. PMID 22128329 DOI: 10.1073/Pnas.1111233109  0.36
2011 Yoon MS, Du G, Backer JM, Frohman MA, Chen J. Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway. The Journal of Cell Biology. 195: 435-47. PMID 22024166 DOI: 10.1083/Jcb.201107033  1
2010 Dbouk HA, Backer JM. A beta version of life: p110β takes center stage. Oncotarget. 1: 729-33. PMID 21321382 DOI: 10.18632/Oncotarget.207  1
2010 Bohdanowicz M, Cosío G, Backer JM, Grinstein S. Class I and class III phosphoinositide 3-kinases are required for actin polymerization that propels phagosomes. The Journal of Cell Biology. 191: 999-1012. PMID 21115805 DOI: 10.1083/Jcb.201004005  1
2010 Dbouk HA, Pang H, Fiser A, Backer JM. A biochemical mechanism for the oncogenic potential of the p110beta catalytic subunit of phosphoinositide 3-kinase. Proceedings of the National Academy of Sciences of the United States of America. 107: 19897-902. PMID 21030680 DOI: 10.1073/Pnas.1008739107  1
2010 Backer JM. The regulation of class IA PI 3-kinases by inter-subunit interactions. Current Topics in Microbiology and Immunology. 346: 87-114. PMID 20544340 DOI: 10.1007/82_2010_52  1
2010 Backer JM. New methods for capturing the mystery lipid, PtdIns5P. The Biochemical Journal. 428: e1-2. PMID 20504279 DOI: 10.1042/Bj20100688  1
2010 Flinn RJ, Backer JM. mTORC1 signals from late endosomes: taking a TOR of the endocytic system. Cell Cycle (Georgetown, Tex.). 9: 1869-70. PMID 20436274 DOI: 10.4161/Cc.9.10.11679  1
2010 Sen KI, Wu H, Backer JM, Gerfen GJ. The structure of p85ni in class IA phosphoinositide 3-kinase exhibits interdomain disorder. Biochemistry. 49: 2159-66. PMID 20131869 DOI: 10.1021/Bi902171D  1
2010 Flinn RJ, Yan Y, Goswami S, Parker PJ, Backer JM. The late endosome is essential for mTORC1 signaling. Molecular Biology of the Cell. 21: 833-41. PMID 20053679 DOI: 10.1091/Mbc.E09-09-0756  1
2009 Jaiswal BS, Janakiraman V, Kljavin NM, Chaudhuri S, Stern HM, Wang W, Kan Z, Dbouk HA, Peters BA, Waring P, Dela Vega T, Kenski DM, Bowman KK, Lorenzo M, Li H, ... ... Backer JM, et al. Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation. Cancer Cell. 16: 463-74. PMID 19962665 DOI: 10.1016/J.Ccr.2009.10.016  1
2009 Wu H, Shekar SC, Flinn RJ, El-Sibai M, Jaiswal BS, Sen KI, Janakiraman V, Seshagiri S, Gerfen GJ, Girvin ME, Backer JM. Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110alpha and are disrupted in oncogenic p85 mutants. Proceedings of the National Academy of Sciences of the United States of America. 106: 20258-63. PMID 19915146 DOI: 10.1073/Pnas.0902369106  1
2009 Pang H, Flinn R, Patsialou A, Wyckoff J, Roussos ET, Wu H, Pozzuto M, Goswami S, Condeelis JS, Bresnick AR, Segall JE, Backer JM. Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase. Cancer Research. 69: 8868-76. PMID 19903845 DOI: 10.1158/0008-5472.Can-09-1968  1
2009 Zhong Y, Wang QJ, Li X, Yan Y, Backer JM, Chait BT, Heintz N, Yue Z. Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex. Nature Cell Biology. 11: 468-76. PMID 19270693 DOI: 10.1038/Ncb1854  1
2009 Yan Y, Flinn RJ, Wu H, Schnur RS, Backer JM. hVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells. The Biochemical Journal. 417: 747-55. PMID 18957027 DOI: 10.1042/Bj20081865  1
2008 Ciraolo E, Iezzi M, Marone R, Marengo S, Curcio C, Costa C, Azzolino O, Gonella C, Rubinetto C, Wu H, Dastrù W, Martin EL, Silengo L, Altruda F, Turco E, ... ... Backer JM, et al. Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development. Science Signaling. 1: ra3. PMID 18780892 DOI: 10.1126/Scisignal.1161577  1
2008 Ono H, Pocai A, Wang Y, Sakoda H, Asano T, Backer JM, Schwartz GJ, Rossetti L. Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats. The Journal of Clinical Investigation. 118: 2959-68. PMID 18618016 DOI: 10.1172/Jci34277  1
2008 Shekar SC, Backer JM, Girvin ME. Effectively doubling the magnetic field in spin-1/2-spin-1, HSQC, HDQC, coupled HSQC, and coupled HDQC in solution NMR. The Journal of Chemical Physics. 128: 184501. PMID 18532820 DOI: 10.1063/1.2906116  1
2008 Cao C, Backer JM, Laporte J, Bedrick EJ, Wandinger-Ness A. Sequential actions of myotubularin lipid phosphatases regulate endosomal PI(3)P and growth factor receptor trafficking. Molecular Biology of the Cell. 19: 3334-46. PMID 18524850 DOI: 10.1091/Mbc.E08-04-0367  1
2008 Juhász G, Hill JH, Yan Y, Sass M, Baehrecke EH, Backer JM, Neufeld TP. The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila. The Journal of Cell Biology. 181: 655-66. PMID 18474623 DOI: 10.1083/Jcb.200712051  1
2008 Sarmiento C, Wang W, Dovas A, Yamaguchi H, Sidani M, El-Sibai M, Desmarais V, Holman HA, Kitchen S, Backer JM, Alberts A, Condeelis J. WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells. The Journal of Cell Biology. 180: 1245-60. PMID 18362183 DOI: 10.1083/Jcb.200708123  1
2008 Weinger JG, Gohari P, Yan Y, Backer JM, Varnum B, Shafit-Zagardo B. In brain, Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation. Journal of Neurochemistry. 106: 134-46. PMID 18346204 DOI: 10.1111/J.1471-4159.2008.05343.X  1
2008 El-Sibai M, Pertz O, Pang H, Yip SC, Lorenz M, Symons M, Condeelis JS, Hahn KM, Backer JM. RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells. Experimental Cell Research. 314: 1540-52. PMID 18316075 DOI: 10.1016/J.Yexcr.2008.01.016  1
2008 Backer JM. The regulation and function of Class III PI3Ks: novel roles for Vps34. The Biochemical Journal. 410: 1-17. PMID 18215151 DOI: 10.1042/Bj20071427  1
2008 Yip SC, Eddy RJ, Branch AM, Pang H, Wu H, Yan Y, Drees BE, Neilsen PO, Condeelis J, Backer JM. Quantification of PtdIns(3,4,5)P(3) dynamics in EGF-stimulated carcinoma cells: a comparison of PH-domain-mediated methods with immunological methods. The Biochemical Journal. 411: 441-8. PMID 18215145 DOI: 10.1042/Bj20071179  1
2007 van Rheenen J, Song X, van Roosmalen W, Cammer M, Chen X, Desmarais V, Yip SC, Backer JM, Eddy RJ, Condeelis JS. EGF-induced PIP2 hydrolysis releases and activates cofilin locally in carcinoma cells. The Journal of Cell Biology. 179: 1247-59. PMID 18086920 DOI: 10.1083/Jcb.200706206  1
2007 Sidani M, Wessels D, Mouneimne G, Ghosh M, Goswami S, Sarmiento C, Wang W, Kuhl S, El-Sibai M, Backer JM, Eddy R, Soll D, Condeelis J. Cofilin determines the migration behavior and turning frequency of metastatic cancer cells. The Journal of Cell Biology. 179: 777-91. PMID 18025308 DOI: 10.1083/Jcb.200707009  1
2007 El-Sibai M, Nalbant P, Pang H, Flinn RJ, Sarmiento C, Macaluso F, Cammer M, Condeelis JS, Hahn KM, Backer JM. Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells. Journal of Cell Science. 120: 3465-74. PMID 17855387 DOI: 10.1242/Jcs.005942  1
2007 Yip SC, El-Sibai M, Coniglio SJ, Mouneimne G, Eddy RJ, Drees BE, Neilsen PO, Goswami S, Symons M, Condeelis JS, Backer JM. The distinct roles of Ras and Rac in PI 3-kinase-dependent protrusion during EGF-stimulated cell migration. Journal of Cell Science. 120: 3138-46. PMID 17698922 DOI: 10.1242/Jcs.005298  1
2007 Cao C, Laporte J, Backer JM, Wandinger-Ness A, Stein MP. Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes. Traffic (Copenhagen, Denmark). 8: 1052-67. PMID 17651088 DOI: 10.1111/J.1600-0854.2007.00586.X  1
2007 Miled N, Yan Y, Hon WC, Perisic O, Zvelebil M, Inbar Y, Schneidman-Duhovny D, Wolfson HJ, Backer JM, Williams RL. Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit. Science (New York, N.Y.). 317: 239-42. PMID 17626883 DOI: 10.1126/Science.1135394  0.36
2007 Chuang YY, Valster A, Coniglio SJ, Backer JM, Symons M. The atypical Rho family GTPase Wrch-1 regulates focal adhesion formation and cell migration. Journal of Cell Science. 120: 1927-34. PMID 17504809 DOI: 10.1242/Jcs.03456  1
2007 Wu H, Yan Y, Backer JM. Regulation of class IA PI3Ks. Biochemical Society Transactions. 35: 242-4. PMID 17371249 DOI: 10.1042/Bst0350242  1
2007 Yan Y, Backer JM. Regulation of class III (Vps34) PI3Ks. Biochemical Society Transactions. 35: 239-41. PMID 17371248 DOI: 10.1042/Bst0350239  1
2007 El-Sibai M, Backer JM. Phospholipase C gamma negatively regulates Rac/Cdc42 activation in antigen-stimulated mast cells. European Journal of Immunology. 37: 261-70. PMID 17163445 DOI: 10.1002/Eji.200635875  1
2006 Srivastava S, Li Z, Ko K, Choudhury P, Albaqumi M, Johnson AK, Yan Y, Backer JM, Unutmaz D, Coetzee WA, Skolnik EY. Histidine phosphorylation of the potassium channel KCa3.1 by nucleoside diphosphate kinase B is required for activation of KCa3.1 and CD4 T cells. Molecular Cell. 24: 665-75. PMID 17157250 DOI: 10.1016/J.Molcel.2006.11.012  1
2005 Murray JT, Backer JM. Analysis of hVps34/hVps15 interactions with Rab5 in Vivo and in Vitro Methods in Enzymology. 403: 789-799. PMID 16473639 DOI: 10.1016/S0076-6879(05)03068-5  1
2005 Nobukuni T, Joaquin M, Roccio M, Dann SG, Kim SY, Gulati P, Byfield MP, Backer JM, Natt F, Bos JL, Zwartkruis FJ, Thomas G. Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. Proceedings of the National Academy of Sciences of the United States of America. 102: 14238-43. PMID 16176982 DOI: 10.1073/Pnas.0506925102  1
2005 Backer JM. Substrate specificity: PI(3)Kgamma has it both ways. Nature Cell Biology. 7: 773-4. PMID 16056269 DOI: 10.1038/Ncb0805-773  1
2005 Byfield MP, Murray JT, Backer JM. hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase Journal of Biological Chemistry. 280: 33076-33082. PMID 16049009 DOI: 10.1074/Jbc.M507201200  1
2005 Shekar SC, Wu H, Fu Z, Yip SC, Nagajyothi, Cahill SM, Girvin ME, Backer JM. Mechanism of constitutive phosphoinositide 3-kinase activation by oncogenic mutants of the p85 regulatory subunit. The Journal of Biological Chemistry. 280: 27850-5. PMID 15932879 DOI: 10.1074/Jbc.M506005200  1
2005 Zamora-Leon SP, Bresnick A, Backer JM, Shafit-Zagardo B. Fyn phosphorylates human MAP-2c on tyrosine 67. The Journal of Biological Chemistry. 280: 1962-70. PMID 15536091 DOI: 10.1074/Jbc.M411380200  1
2004 Fu Z, Aronoff-Spencer E, Wu H, Gerfen GJ, Backer JM. The iSH2 domain of PI 3-kinase is a rigid tether for p110 and not a conformational switch. Archives of Biochemistry and Biophysics. 432: 244-51. PMID 15542063 DOI: 10.1016/J.Abb.2004.09.032  1
2004 Yip SC, El-Sibai M, Hill KM, Wu H, Fu Z, Condeelis JS, Backer JM. Over-expression of the p110beta but not p110alpha isoform of PI 3-kinase inhibits motility in breast cancer cells. Cell Motility and the Cytoskeleton. 59: 180-8. PMID 15468162 DOI: 10.1002/Cm.20032  1
2004 Mouneimne G, Soon L, DesMarais V, Sidani M, Song X, Yip SC, Ghosh M, Eddy R, Backer JM, Condeelis J. Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation. The Journal of Cell Biology. 166: 697-708. PMID 15337778 DOI: 10.1083/Jcb.200405156  1
2004 Lucocq JM, Habermann A, Watt S, Backer JM, Mayhew TM, Griffiths G. A rapid method for assessing the distribution of gold labeling on thin sections Journal of Histochemistry and Cytochemistry. 52: 991-1000. PMID 15258174 DOI: 10.1369/Jhc.3A6178.2004  1
2003 Kempiak SJ, Yip SC, Backer JM, Segall JE. Local signaling by the EGF receptor. The Journal of Cell Biology. 162: 781-7. PMID 12952932 DOI: 10.1083/Jcb.200303144  1
2003 Wu H, Windmiller DA, Wang L, Backer JM. YXXM motifs in the PDGF-beta receptor serve dual roles as phosphoinositide 3-kinase binding motifs and tyrosine-based endocytic sorting signals. The Journal of Biological Chemistry. 278: 40425-8. PMID 12941951 DOI: 10.1074/Jbc.C300225200  1
2003 Fu Z, Aronoff-Spencer E, Backer JM, Gerfen GJ. The structure of the inter-SH2 domain of class IA phosphoinositide 3-kinase determined by site-directed spin labeling EPR and homology modeling. Proceedings of the National Academy of Sciences of the United States of America. 100: 3275-80. PMID 12629217 DOI: 10.1073/Pnas.0535975100  1
2003 Windmiller DA, Backer JM. Distinct phosphoinositide 3-kinases mediate mast cell degranulation in response to G-protein-coupled versus FcepsilonRI receptors. The Journal of Biological Chemistry. 278: 11874-8. PMID 12529321 DOI: 10.1074/Jbc.M211787200  1
2002 Eskelinen EL, Prescott AR, Cooper J, Brachmann SM, Wang L, Tang X, Backer JM, Lucocq JM. Inhibition of autophagy in mitotic animal cells. Traffic (Copenhagen, Denmark). 3: 878-93. PMID 12453151 DOI: 10.1034/J.1600-0854.2002.31204.X  1
2002 Lu Z, Murray JT, Luo W, Li H, Wu X, Xu H, Backer JM, Chen YG. Transforming growth factor β activates Smad2 in the absence of receptor endocytosis Journal of Biological Chemistry. 277: 29363-29368. PMID 12034739 DOI: 10.1074/Jbc.M203495200  1
2002 Murray JT, Panaretou C, Stenmark H, Miaczynska M, Backer JM. Role of Rab5 in the recruitment of hVps34/p150 to the early endosome Traffic. 3: 416-427. PMID 12010460 DOI: 10.1034/J.1600-0854.2002.30605.X  1
2001 Futter CE, Collinson LM, Backer JM, Hopkins CR. Human VPS34 is required for internal vesicle formation within multivesicular endosomes. The Journal of Cell Biology. 155: 1251-64. PMID 11756475 DOI: 10.1083/Jcb.200108152  1
2001 Tuma PL, Nyasae LK, Backer JM, Hubbard AL. Vps34p differentially regulates endocytosis from the apical and basolateral domains in polarized hepatic cells. The Journal of Cell Biology. 154: 1197-208. PMID 11564757 DOI: 10.1083/Jcb.200105138  1
2001 Fratti RA, Backer JM, Gruenberg J, Corvera S, Deretic V. Role of phosphatidylinositol 3-kinase and Rab5 effectors in phagosomal biogenesis and mycobacterial phagosome maturation arrest. The Journal of Cell Biology. 154: 631-44. PMID 11489920 DOI: 10.1083/Jcb.200106049  1
2001 Smith AJ, Surviladze Z, Gaudet EA, Backer JM, Mitchell CA, Wilson BS. p110beta and p110delta phosphatidylinositol 3-kinases up-regulate Fc(epsilon)RI-activated Ca2+ influx by enhancing inositol 1,4,5-trisphosphate production. The Journal of Biological Chemistry. 276: 17213-20. PMID 11279065 DOI: 10.1074/jbc.M100417200  1
2001 Hill KM, Huang Y, Yip SC, Yu J, Segall JE, Backer JM. N-terminal domains of the class ia phosphoinositide 3-kinase regulatory subunit play a role in cytoskeletal but not mitogenic signaling. The Journal of Biological Chemistry. 276: 16374-8. PMID 11278326 DOI: 10.1074/Jbc.M006985200  1
2000 Backer JM. Phosphoinositide 3-kinases and the regulation of vesicular trafficking Molecular Cell Biology Research Communications. 3: 193-204. PMID 10891392 DOI: 10.1006/Mcbr.2000.0202  1
2000 Siddhanta A, Backer JM, Shields D. Inhibition of phosphatidic acid synthesis alters the structure of the Golgi apparatus and inhibits secretion in endocrine cells Journal of Biological Chemistry. 275: 12023-12031. PMID 10766834 DOI: 10.1074/Jbc.275.16.12023  1
2000 Hill K, Welti S, Yu J, Murray JT, Yip SC, Condeelis JS, Segall JE, Backer JM. Specific requirement for the p85-p110alpha phosphatidylinositol 3-kinase during epidermal growth factor-stimulated actin nucleation in breast cancer cells. The Journal of Biological Chemistry. 275: 3741-4. PMID 10660520 DOI: 10.1074/Jbc.275.6.3741  1
1999 Nielsen E, Severin F, Backer JM, Hyman AA, Zerial M. Rab5 regulates motility of early endosomes on microtubules Nature Cell Biology. 1: 376-382. PMID 10559966 DOI: 10.1038/14075  1
1999 Christoforidis S, Miaczynska M, Ashman K, Wilm M, Zhao L, Yip SC, Waterfield MD, Backer JM, Zerial M. Phosphatidylinositol-3-OH kinases are Rab5 effectors. Nature Cell Biology. 1: 249-52. PMID 10559924 DOI: 10.1038/12075  1
1999 Hawkins M, Hu M, Yu J, Eder H, Vuguin P, She L, Barzilai N, Leiser M, Backer JM, Rossetti L. Discordant effects of glucosamine on insulin-stimulated glucose metabolism and phosphatidylinositol 3-kinase activity Journal of Biological Chemistry. 274: 31312-31319. PMID 10531330 DOI: 10.1074/Jbc.274.44.31312  1
1999 Cass LA, Summers SA, Prendergast GV, Backer JM, Birnbaum MJ, Meinkoth JL. Protein kinase A-dependent and -independent signaling pathways contribute to cyclic AMP-stimulated proliferation Molecular and Cellular Biology. 19: 5882-5891. PMID 10454535 DOI: 10.1128/Mcb.19.9.5882  1
1998 Siddhanta U, McIlroy J, Shah A, Zhang Y, Backer JM. Distinct roles for the p110α and hVPS34 phosphatidylinositol 3'- kinases in vesicular trafficking, regulation of the actin cytoskeleton, and mitogenesis Journal of Cell Biology. 143: 1647-1659. PMID 9852157 DOI: 10.1083/Jcb.143.6.1647  1
1998 Yu J, Wjasow C, Backer JM. Regulation of the p85/p110α phosphatidylinositol 3'-kinase: Distinct roles for the n-terminal and c-terminal sh2 domains Journal of Biological Chemistry. 273: 30199-30203. PMID 9804776 DOI: 10.1074/Jbc.273.46.30199  1
1998 Yu J, Zhang Y, McIlroy J, Rordorf-Nikolic T, Orr GA, Backer JM. Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit. Molecular and Cellular Biology. 18: 1379-87. PMID 9488453 DOI: 10.1128/Mcb.18.3.1379  1
1997 Backer JM, Wjasow C, Zhang Y. La vitro binding and phosphorylation of insulin receptor substrate 1 by the insulin receptor. Role of interactions mediated by the phosphotyrosine-binding domain and the pleckstrin-homology domain European Journal of Biochemistry. 245: 91-96. PMID 9128728 DOI: 10.1111/J.1432-1033.1997.T01-1-00091.X  1
1997 McIlroy J, Chen D, Wjasow C, Michaeli T, Backer JM. Specific activation of p85-p110 phosphatidylinositol 3'-kinase stimulates DNA synthesis by ras- and p70 S6 kinase-dependent pathways Molecular and Cellular Biology. 17: 248-255. PMID 8972205 DOI: 10.1128/Mcb.17.1.248  1
1996 Martys JL, Wjasow C, Gangi DM, Kielian MC, McGraw TE, Backer JM. Wortmannin-sensitive trafficking pathways in Chinese hamster ovary cells: Differential effects on endocytosis and lysosomal sorting Journal of Biological Chemistry. 271: 10953-10962. PMID 8631914 DOI: 10.1074/Jbc.271.18.10953  1
1995 Rordorf-Nikolic T, Van Horn DJ, Chen D, White MF, Backer JM. Regulation of phosphatidylinositol 3′-kinase by tyrosyl phosphoproteins: Full activation requires occupancy of both SH2 domains in the 85-kDa regulatory subunit Journal of Biological Chemistry. 270: 3662-3666. PMID 7876105 DOI: 10.1074/Jbc.270.8.3662  1
1995 Chen D, Van Horn DJ, White MF, Backer JM. Insulin receptor substrate 1 rescues insulin action in CHO cells expressing mutant insulin receptors that lack a juxtamembrane NPXY motif Molecular and Cellular Biology. 15: 4711-4717. PMID 7651388 DOI: 10.1128/Mcb.15.9.4711  1
1995 Myers MG, Cheatham B, Fisher TL, Jachna BR, Kahn CR, Backer JM, White MF. Common and distinct elements in insulin and PDGF signaling. Annals of the New York Academy of Sciences. 766: 369-87. PMID 7486683 DOI: 10.1111/J.1749-6632.1995.Tb26687.X  1
1994 Van Horn DJ, Myers MG, Backer JM. Direct activation of the phosphatidylinositol 3′-kinase by the insulin receptor Journal of Biological Chemistry. 269: 29-32. PMID 8276809  1
1993 Feener EP, Backer JM, King GL, Wilden PA, Sun XJ, Kahn CR, White MF. Insulin stimulates serine and tyrosine phosphorylation in the juxtamembrane region of the insulin receptor Journal of Biological Chemistry. 268: 11256-11264. PMID 8496180  1
1993 Chuang LM, Myers MG, Backer JM, Shoelson SE, White MF, Birnbaum MJ, Kahn CR. Insulin-stimulated oocyte maturation requires insulin receptor substrate 1 and interaction with the SH2 domains of phosphatidylinositol 3-kinase. Molecular and Cellular Biology. 13: 6653-60. PMID 8413261 DOI: 10.1128/Mcb.13.11.6653  1
1993 Goncalves E, Yamada K, Thatte HS, Backer JM, Golan DE, Kahn CR, Shoelson SE. Optimizing transmembrane domain helicity accelerates insulin receptor internalization and lateral mobility. Proceedings of the National Academy of Sciences of the United States of America. 90: 5762-6. PMID 8390680 DOI: 10.1073/Pnas.90.12.5762  1
1993 Backer JM, Myers MG, Sun XJ, Chin DJ, Shoelson SE, Miralpeix M, White MF. Association of IRS-1 with the insulin receptor and the phosphatidylinositol 3'-kinase. Formation of binary and ternary signaling complexes in intact cells. The Journal of Biological Chemistry. 268: 8204-12. PMID 8385139  1
1993 Myers MG, Sun XJ, Cheatham B, Jachna BR, Glasheen EM, Backer JM, White MF. IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3′-kinase Endocrinology. 132: 1421-1430. PMID 8384986 DOI: 10.1210/Endo.132.4.8384986  1
1993 Shoelson SE, Lee J, Lynch CS, Backer JM, Pilch PF. BpaB25 insulins. Photoactivatable analogues that quantitatively cross-link, radiolabel, and activate the insulin receptor. The Journal of Biological Chemistry. 268: 4085-91. PMID 8382690  1
1993 Folli F, Saad MJA, Backer JM, Ronald Kahn C. Regulation of Phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus Journal of Clinical Investigation. 92: 1787-1794. PMID 7691886 DOI: 10.1172/Jci116768  1
1992 Backer JM, Shoelson SE, Weiss MA, Hua QX, Cheatham RB, Haring E, Cahill DC, White MF. The insulin receptor juxtamembrane region contains two independent tyrosine/beta-turn internalization signals. The Journal of Cell Biology. 118: 831-9. PMID 1500426 DOI: 10.1083/Jcb.118.4.831  1
1992 Meyerovitch J, Backer JM, Csermely P, Shoelson SE, Kahn CR. Insulin differentially regulates protein phosphotyrosine phosphatase activity in rat hepatoma cells. Biochemistry. 31: 10338-44. PMID 1420153 DOI: 10.1021/Bi00157A023  1
1992 Sun XJ, Miralpeix M, Myers MG, Glasheen EM, Backer JM, Kahn CR, White MF. Expression and function of IRS-1 in insulin signal transmission Journal of Biological Chemistry. 267: 22662-22672. PMID 1385403  1
1992 Folli F, Saad MJA, Backer JM, Kahn CR. Insulin stimulation of phosphatidylinositol 3-kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat Journal of Biological Chemistry. 267: 22171-22177. PMID 1385396  1
1992 Miralpeix M, Sun XJ, Backer JM, Myers MG, Araki E, White MF. Insulin stimulates tyrosine phosphorylation of multiple high molecular weight substrates in Fao hepatoma cells Biochemistry. 31: 9031-9039. PMID 1382584 DOI: 10.1021/Bi00152A046  1
1992 Myers MG, Backer JM, Sun XJ, Shoelson S, Hu P, Schlessinger J, Yoakim M, Schaffhausen B, White MF. IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85. Proceedings of the National Academy of Sciences of the United States of America. 89: 10350-4. PMID 1332046 DOI: 10.1073/Pnas.89.21.10350  1
1992 Wilden PA, Siddle K, Haring E, Backer JM, White MF, Kahn CR. The role of insulin receptor kinase domain autophosphorylation in receptor-mediated activities: Analysis with insulin and anti-receptor antibodies Journal of Biological Chemistry. 267: 13719-13727. PMID 1320027  1
1992 Backer JM, Schroeder GG, Kahn CR, Myers MG, Wilden PA, Cahill DA, White MF. Insulin stimulation of phosphatidylinositol 3-kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation Journal of Biological Chemistry. 267: 1367-1374. PMID 1309768  1
1991 Backer JM, King GL. Regulation of receptor-mediated endocytosis by phorbol esters Biochemical Pharmacology. 41: 1267-1277. PMID 1850281 DOI: 10.1016/0006-2952(91)90097-O  1
1991 Backer JM, Shoelson SE, Haring E, White MF. Insulin receptors internalize by a rapid, saturable pathway requiring receptor autophosphorylation and an intact juxtamembrane region. The Journal of Cell Biology. 115: 1535-45. PMID 1757462 DOI: 10.1083/Jcb.115.6.1535  1
1991 White MF, Backer JM. Preparation and use of anti-phosphotyrosine antibodies to study structure and function of insulin receptor Methods in Enzymology. 201: 65-79. PMID 1719349 DOI: 10.1016/0076-6879(91)01009-Q  1
1991 Yamaguchi Y, Flier JS, Yokota A, Benecke H, Backer JM, Moller DE. Functional properties of two naturally occurring isoforms of the human insulin receptor in chinese hamster ovary cells Endocrinology. 129: 2058-2066. PMID 1655392 DOI: 10.1210/Endo-129-4-2058  1
1991 Sun XJ, Rothenberg P, Kahn CR, Backer JM, Araki E, Wilden PA, Cahill DA, Goldstein BJ, White MF. Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein Nature. 352: 73-76. PMID 1648180 DOI: 10.1038/352073A0  1
1991 Backer JM. Cytoplasmic juxtamembrane region of the insulin receptor: A critical role in ATP binding, endogenous substrate phosphorylation, and insulin-stimulated bioeffects in CHO cells Biochemistry. 30: 6366-6372. PMID 1647198 DOI: 10.1021/Bi00240A003  1
1991 Myers MG, Backer JM, Siddle K, White MF. The insulin receptor functions normally in chinese hamster ovary cells after truncation of the C terminus Journal of Biological Chemistry. 266: 10616-10623. PMID 1645354  1
1990 Backer JM, Kahn CR, Cahill DA, Ullrich A, White MF. Receptor-mediated internalization of insulin requires a 12-amino acid sequence in the juxtamembrane region of the insulin receptor β-subunit Journal of Biological Chemistry. 265: 16450-16454. PMID 2204623  1
1990 Backer JM, Kahn CR, White MF. The dissociation and degradation of internalized insulin occur in the endosomes of rat hepatoma cells Journal of Biological Chemistry. 265: 14828-14835. PMID 2203763  1
1990 Hu KQ, Backer JM, Sahagian G, Feener EP, King GL. Modulation of the insulin growth factor II/mannose 6-phosphate receptor of microvascular endothelial cells by phorbol ester via protein kinase C Journal of Biological Chemistry. 265: 13864-13870. PMID 2166043  1
1990 Wilden PA, Backer JM, Kahn CR, Cahill DA, Schroeder GJ, White MF. The insulin receptor with phenylalanine replacing tyrosine-1146 provides evidence for separate signals regulating cellular metabolism and growth Proceedings of the National Academy of Sciences of the United States of America. 87: 3358-3362. PMID 2159147 DOI: 10.1073/Pnas.87.9.3358  1
1989 Meyerovitch J, Backer JM, Kahn CR. Hepatic phosphotyrosine phosphatase activity and its alterations in diabetic rats Journal of Clinical Investigation. 84: 976-983. PMID 2547842 DOI: 10.1172/Jci114261  1
1989 Shymko RM, Gonzales NS, Backer JM, White MF, Meyts PD. Binding kinetics of mutated insulin receptors in transfected cells grown in suspension culture: Application to the Tyr → Phe 960 insulin receptor mutant Biochemical and Biophysical Research Communications. 164: 191-198. PMID 2508634 DOI: 10.1016/0006-291X(89)91701-4  1
1989 Backer JM, Kahn CR, White MF. Tyrosine phosphorylation of the insulin receptor is not required for receptor internalization: Studies in 2,4-dinitrophenol-treated cells Proceedings of the National Academy of Sciences of the United States of America. 86: 3209-3213. PMID 2470095 DOI: 10.1073/Pnas.86.9.3209  1
1989 Backer JM, Kahn CR, White MF. Tyrosine phosphorylation of the insulin receptor during insulin-stimulated internalization in rat hepatoma cells Journal of Biological Chemistry. 264: 1694-1701. PMID 2463986  1
1988 White MF, Livingston JN, Backer JM, Lauris V, Dull TJ, Ullrich A, Kahn CR. Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity Cell. 54: 641-649. PMID 2842060 DOI: 10.1016/S0092-8674(88)80008-4  1
1987 Backer JM, Dawidowicz EA. Reconstitution of a phospholipid flippase from rat liver microsomes Nature. 327: 341-343. PMID 3587349 DOI: 10.1038/327341A0  1
1986 Dice JF, Chiang HL, Spencer EP, Backer JM. Regulation of catabolism of microinjected ribonuclease A. Identification of residues 7-11 as the essential pentapeptide Journal of Biological Chemistry. 261: 6853-6859. PMID 3700419  1
1986 Backer JM, Dice JF. Covalent linkage of ribonuclease S-peptide to microinjected proteins causes their intracellular degradation to be enhanced during serum withdrawal Proceedings of the National Academy of Sciences of the United States of America. 83: 5830-5834. PMID 3526340  1
1985 Dice JF, Backer JM, Miao P, Bourret L, McElligott MA. Regulation of catabolism of ribonuclease A microinjected into human fibroblasts Progress in Clinical and Biological Research. 180: 385-394. PMID 4034548  1
1983 Backer JM, Bourret L, Dice JF. Regulation of catabolism of microinjected ribonuclease A requires the amino-terminal 20 amino acids Proceedings of the National Academy of Sciences of the United States of America. 80: 2166-2170. PMID 6572969 DOI: 10.1073/Pnas.80.8.2166  1
1981 Backer JM, Dawidowicz EA. Mechanism of cholesterol exchange between phospholipid vesicles Biochemistry. 20: 3805-3810. PMID 7272277 DOI: 10.1021/Bi00516A021  1
1981 Dawidowicz EA, Backer JM. The rapid transbilayer movement of thiocholesterol in small unilamellar phospholipid vesicles Bba - Biomembranes. 644: 373-375. PMID 7260079 DOI: 10.1016/0005-2736(81)90396-5  1
1981 Backer JM, Dawidowicz EA. Transmembrane movement of cholesterol in small unilamellar vesicles detected by cholesterol oxidase Journal of Biological Chemistry. 256: 586-588. PMID 6935193  1
1979 Backer JM, Dawidowicz EA. The rapid transmembrane movement of cholesterol in small unilamellar vesicles Biochimica Et Biophysica Acta. 551: 260-270. PMID 420833 DOI: 10.1016/0005-2736(89)90004-7  1
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