| Year |
Citation |
Score |
| 2022 |
Stickdorn J, Stein L, Arnold-Schild D, Hahlbrock J, Medina-Montano C, Bartneck J, Ziß T, Montermann E, Kappel C, Hobernik D, Haist M, Yurugi H, Raabe M, Best A, Rajalingam K, ... ... David SA, et al. Systemically Administered TLR7/8 Agonist and Antigen-Conjugated Nanogels Govern Immune Responses against Tumors. Acs Nano. PMID 35103463 DOI: 10.1021/acsnano.1c10709 |
0.328 |
|
| 2021 |
Jangra S, De Vrieze J, Choi A, Rathnasinghe R, Laghlali G, Uvyn A, Van Herck S, Nuhn L, Deswarte K, Zhong Z, Sanders NN, Lienenklaus S, David SA, Strohmeier S, Amanat F, et al. Corrigendum: Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine. Angewandte Chemie (International Ed. in English). 60: 16741-16742. PMID 34278670 DOI: 10.1002/anie.202105635 |
0.323 |
|
| 2021 |
Huppertsberg A, Kaps L, Zhong Z, Schmitt S, Stickdorn J, Deswarte K, Combes F, Czysch C, De Vrieze J, Kasmi S, Choteschovsky N, Klefenz A, Medina-Montano C, Winterwerber P, Chen C, ... ... David SA, et al. Squaric Ester-Based, pH-Degradable Nanogels: Modular Nanocarriers for Safe, Systemic Administration of Toll-like Receptor 7/8 Agonistic Immune Modulators. Journal of the American Chemical Society. PMID 34166595 DOI: 10.1021/jacs.1c03772 |
0.405 |
|
| 2020 |
Li H, Van Herck S, Liu Y, Hao Y, Ding X, Nuhn L, Zhong Z, Combes F, Sanders NN, Lienenklaus S, Koker SD, David SA, Wang Y, De Geest BG, Zhang Z. Imidazoquinoline-Conjugated Degradable Coacervate Conjugate for Local Cancer Immunotherapy. Acs Biomaterials Science & Engineering. 6: 4993-5000. PMID 33455292 DOI: 10.1021/Acsbiomaterials.0C00485 |
0.423 |
|
| 2020 |
Wang B, Van Herck S, Chen Y, Bai X, Zhong Z, De Swarte K, Lambrecht BN, Sanders NN, Lienenklaus S, Scheeren HW, David SA, Kiessling F, Lammers T, De Geest BG, Shi Y. Prolonged innate immune activation by enzyme-sensitive imidazoquinoline TLR7/8 agonist prodrug vesicles. Journal of the American Chemical Society. PMID 32524819 DOI: 10.1021/Jacs.0C01928 |
0.587 |
|
| 2020 |
Kockelmann J, Stickdorn J, Kasmi S, De Vrieze J, Pieszka M, Ng DYW, David SA, De Geest BG, Nuhn L. Control over Imidazoquinoline Immune Stimulation by pH-Degradable Poly(norbornene) Nanogels. Biomacromolecules. PMID 32255626 DOI: 10.1021/Acs.Biomac.0C00205 |
0.559 |
|
| 2019 |
De Vrieze J, Louage B, De Swarte K, Zhong Z, De Coen R, Van Herck S, Nuhn L, Frich CK, Zelikin A, Lienenklaus S, Sanders N, David S, Lambrecht B, de Geest B. Potent lymphatic translocation and spatial control over innate immune activation by polymer-lipid amphiphile conjugates of small molecule TLR7/8 agonists. Angewandte Chemie (International Ed. in English). PMID 31397948 DOI: 10.1002/Anie.201905687 |
0.489 |
|
| 2019 |
Hu Z, Banothu J, Beesu M, Gustafson CJ, Brush MJH, Trautman KL, Salyer ACD, Pathakumari B, David SA. Identification of Human Toll-like Receptor 2-Agonistic Activity in Dihydropyridine-Quinolone Carboxamides. Acs Medicinal Chemistry Letters. 10: 132-136. PMID 30655960 DOI: 10.1021/Acsmedchemlett.8B00540 |
0.577 |
|
| 2019 |
De Vrieze J, Louage B, Deswarte K, Zhong Z, De Coen R, Van Herck S, Nuhn L, Kaas Frich C, Zelikin AN, Lienenklaus S, Sanders NN, Lambrecht BN, David SA, De Geest BG. Amphiphile Polymer‐Lipidkonjugate zur potenten lymphatischen Anreicherung von TLR7/8‐Agonisten ermöglichen eine örtlich begrenzte Aktivierung des angeborenen Immunsystems Angewandte Chemie. 131: 15535-15541. DOI: 10.1002/Ange.201905687 |
0.471 |
|
| 2018 |
Zhang Z, Ohto U, Shibata T, Taoka M, Yamauchi Y, Sato R, Shukla NM, David SA, Isobe T, Miyake K, Shimizu T. Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands. Cell Reports. 25: 3371-3381.e5. PMID 30566863 DOI: 10.1016/J.Celrep.2018.11.081 |
0.788 |
|
| 2018 |
Van Herck S, Deswarte K, Nuhn L, Zhong Z, Portela Catani JP, Li Y, Sanders NN, Lienenklaus S, de Koker S, Lambrecht BN, David SA, De Geest BG. Lymph node targeted immune-activation by engineered block copol-ymer amphiphiles - TLR7/8 agonist conjugates. Journal of the American Chemical Society. PMID 30277761 DOI: 10.1021/Jacs.8B08595 |
0.511 |
|
| 2018 |
Nuhn L, De Koker S, Van Lint S, Zhong Z, Catani JP, Combes F, Deswarte K, Li Y, Lambrecht BN, Lienenklaus S, Sanders NN, David SA, Tavernier J, De Geest BG. Nanoparticle-Conjugate TLR7/8 Agonist Localized Immunotherapy Provokes Safe Antitumoral Responses. Advanced Materials (Deerfield Beach, Fla.). e1803397. PMID 30276880 DOI: 10.1002/Adma.201803397 |
0.459 |
|
| 2018 |
Yoo E, Salyer ACD, Brush MJH, Li Y, Trautman KL, Shukla NM, De Beuckelaer A, Lienenklaus S, Deswarte K, Lambrecht B, De Geest BG, David SA. Hyaluronic Acid Conjugates of TLR7/8 Agonists for Targeted Delivery to Secondary Lymphoid Tissue. Bioconjugate Chemistry. PMID 29969553 DOI: 10.1021/Acs.Bioconjchem.8B00386 |
0.757 |
|
| 2018 |
Salyer ACD, David SA. Transcriptomal signatures of vaccine adjuvants and accessory immunostimulation of sentinel cells by toll-like receptor 2/6 agonists. Human Vaccines & Immunotherapeutics. 1-31. PMID 29852079 DOI: 10.1080/21645515.2018.1480284 |
0.613 |
|
| 2018 |
Nuhn L, Van Hoecke L, Deswarte K, Schepens B, Li Y, Lambrecht BN, De Koker S, David SA, Saelens X, De Geest BG. Potent anti-viral vaccine adjuvant based on pH-degradable nanogels with covalently linked small molecule imidazoquinoline TLR7/8 agonist. Biomaterials. PMID 29573820 DOI: 10.1016/J.Biomaterials.2018.03.026 |
0.442 |
|
| 2017 |
Van Herck S, Van Hoecke L, Louage B, Lybaert L, De Coen R, Kasmi S, Esser-Kahn AP, David SA, Nuhn L, Schepens B, Saelens X, De Geest BG. Transiently Thermoresponsive Acetal Polymers for Safe and Effective Administration of Amphotericin B as a Vaccine Adjuvant. Bioconjugate Chemistry. PMID 29172458 DOI: 10.1021/Acs.Bioconjchem.7B00641 |
0.45 |
|
| 2017 |
Beesu M, Salyer AC, Brush MJ, Trautman KL, Hill JK, David SA. Identification of High-potency Human TLR8 and Dual TLR7/TLR8 Agonists in Pyrimidine-2,4-diamines. Journal of Medicinal Chemistry. PMID 28146629 DOI: 10.1021/Acs.Jmedchem.6B01860 |
0.588 |
|
| 2017 |
Beesu M, Kokatla HP, David SA. Syntheses of Human TLR8-Specific Small-Molecule Agonists. Methods in Molecular Biology (Clifton, N.J.). 1494: 29-44. PMID 27718184 DOI: 10.1007/978-1-4939-6445-1_3 |
0.806 |
|
| 2016 |
Beesu M, Salyer AC, Trautman KL, Hill JK, David SA. Human Toll-like Receptor (TLR) 8-specific Agonistic Activity in Substituted Pyrimidine-2,4-diamines. Journal of Medicinal Chemistry. PMID 27513008 DOI: 10.1021/Acs.Jmedchem.6B00872 |
0.509 |
|
| 2016 |
Nuhn L, Vanparijs N, De Beuckelaer A, Lybaert L, Verstraete G, Deswarte K, Lienenklaus S, Shukla NM, Salyer AC, Lambrecht BN, Grooten J, David SA, De Koker S, De Geest BG. pH-degradable imidazoquinoline-ligated nanogels for lymph node-focused immune activation. Proceedings of the National Academy of Sciences of the United States of America. PMID 27382168 DOI: 10.1073/Pnas.1600816113 |
0.785 |
|
| 2016 |
Beesu M, Caruso G, Salyer AC, Shukla NM, Khetani KK, Smith LJ, Fox LM, Tanji H, Ohto U, Shimizu T, David SA. Identification of a Human Toll-like Receptor (TLR) 8-specific Agonist and a Functional Pan-TLR Inhibitor in 2-Aminoimidazoles. Journal of Medicinal Chemistry. PMID 26966993 DOI: 10.1021/Acs.Jmedchem.6B00023 |
0.808 |
|
| 2016 |
Salyer AC, Caruso G, Khetani KK, Fox LM, Malladi SS, David SA. Identification of Adjuvantic Activity of Amphotericin B in a Novel, Multiplexed, Poly-TLR/NLR High-Throughput Screen. Plos One. 11: e0149848. PMID 26919709 DOI: 10.1371/Journal.Pone.0149848 |
0.617 |
|
| 2016 |
Pashikanti S, Ukani R, David SA, Datta A. Total Synthesis and Structure-Activity Relationship Studies of the Cytotoxic Anhydrophytosphingosine Jaspine B(Pachastrissamine) Synthesis. 49: 2088-2100. DOI: 10.1055/S-0036-1588118 |
0.307 |
|
| 2015 |
Beesu M, Caruso G, Salyer AC, Khetani KK, Sil D, Weerasinghe M, Tanji H, Ohto U, Shimizu T, David SA. Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity. Journal of Medicinal Chemistry. 58: 7833-49. PMID 26351878 DOI: 10.1021/Acs.Jmedchem.5B01087 |
0.59 |
|
| 2015 |
Ganapathi L, Van Haren S, Dowling DJ, Bergelson I, Shukla NM, Malladi SS, Balakrishna R, Tanji H, Ohto U, Shimizu T, David SA, Levy O. The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes. Plos One. 10: e0134640. PMID 26274907 DOI: 10.1371/Journal.Pone.0134640 |
0.765 |
|
| 2014 |
Yoo E, Salunke DB, Sil D, Guo X, Salyer AC, Hermanson AR, Kumar M, Malladi SS, Balakrishna R, Thompson WH, Tanji H, Ohto U, Shimizu T, David SA. Determinants of activity at human Toll-like receptors 7 and 8: quantitative structure-activity relationship (QSAR) of diverse heterocyclic scaffolds. Journal of Medicinal Chemistry. 57: 7955-70. PMID 25192394 DOI: 10.1021/Jm500744F |
0.625 |
|
| 2014 |
Beesu M, Malladi SS, Fox LM, Jones CD, Dixit A, David SA. Human Toll-like receptor 8-selective agonistic activities in 1-alkyl-1H-benzimidazol-2-amines. Journal of Medicinal Chemistry. 57: 7325-41. PMID 25102141 DOI: 10.1021/Jm500701Q |
0.596 |
|
| 2014 |
Kokatla HP, Sil D, Tanji H, Ohto U, Malladi SS, Fox LM, Shimizu T, David SA. Structure-based design of novel human Toll-like receptor 8 agonists. Chemmedchem. 9: 719-23. PMID 24474703 DOI: 10.1002/Cmdc.201300573 |
0.832 |
|
| 2013 |
Sil D, Heinbockel L, Kaconis Y, Rössle M, Garidel P, Gutsmann T, David SA, Brandenburg K. Biophysical mechanisms of the neutralization of endotoxins by lipopolyamines. The Open Biochemistry Journal. 7: 82-93. PMID 24133550 DOI: 10.2174/1874091X01307010082 |
0.43 |
|
| 2013 |
Yoo E, Crall BM, Balakrishna R, Malladi SS, Fox LM, Hermanson AR, David SA. Structure-activity relationships in Toll-like receptor 7 agonistic 1H-imidazo[4,5-c]pyridines. Organic & Biomolecular Chemistry. 11: 6526-45. PMID 23974333 DOI: 10.1039/C3Ob40816G |
0.566 |
|
| 2013 |
Kokatla HP, Sil D, Malladi SS, Balakrishna R, Hermanson AR, Fox LM, Wang X, Dixit A, David SA. Exquisite selectivity for human toll-like receptor 8 in substituted furo[2,3-c]quinolines. Journal of Medicinal Chemistry. 56: 6871-85. PMID 23899291 DOI: 10.1021/Jm400694D |
0.824 |
|
| 2013 |
Salunke DB, Connelly SW, Shukla NM, Hermanson AR, Fox LM, David SA. Design and development of stable, water-soluble, human Toll-like receptor 2 specific monoacyl lipopeptides as candidate vaccine adjuvants. Journal of Medicinal Chemistry. 56: 5885-900. PMID 23795818 DOI: 10.1021/Jm400620G |
0.797 |
|
| 2013 |
Kokatla HP, Yoo E, Salunke DB, Sil D, Ng CF, Balakrishna R, Malladi SS, Fox LM, David SA. Toll-like receptor-8 agonistic activities in C2, C4, and C8 modified thiazolo[4,5-c]quinolines. Organic & Biomolecular Chemistry. 11: 1179-98. PMID 23314908 DOI: 10.1039/C2Ob26705E |
0.807 |
|
| 2012 |
Shukla NM, Salunke DB, Balakrishna R, Mutz CA, Malladi SS, David SA. Potent adjuvanticity of a pure TLR7-agonistic imidazoquinoline dendrimer. Plos One. 7: e43612. PMID 22952720 DOI: 10.1371/Journal.Pone.0043612 |
0.809 |
|
| 2012 |
Shukla NM, Salunke DB, Yoo E, Mutz CA, Balakrishna R, David SA. Antibacterial activities of Groebke-Blackburn-Bienaymé-derived imidazo[1,2-a]pyridin-3-amines. Bioorganic & Medicinal Chemistry. 20: 5850-63. PMID 22925449 DOI: 10.1016/J.Bmc.2012.07.052 |
0.724 |
|
| 2012 |
Salunke DB, Yoo E, Shukla NM, Balakrishna R, Malladi SS, Serafin KJ, Day VW, Wang X, David SA. Structure-activity relationships in human Toll-like receptor 8-active 2,3-diamino-furo[2,3-c]pyridines. Journal of Medicinal Chemistry. 55: 8137-51. PMID 22924757 DOI: 10.1021/Jm301066H |
0.79 |
|
| 2012 |
Schuerholz T, Dömming S, Hornef M, Dupont A, Kowalski I, Kaconis Y, Heinbockel L, Andrä J, Garidel P, Gutsmann T, David S, Sánchez-Gómez S, Martinez de Tejada G, Brandenburg K. Bacterial cell wall compounds as promising targets of antimicrobial agents II. Immunological and clinical aspects. Current Drug Targets. 13: 1131-7. PMID 22664073 DOI: 10.2174/138945012802002438 |
0.333 |
|
| 2012 |
Martínez de Tejada G, Sánchez-Gómez S, Rázquin-Olazaran I, Kowalski I, Kaconis Y, Heinbockel L, Andrä J, Schürholz T, Hornef M, Dupont A, Garidel P, Lohner K, Gutsmann T, David SA, Brandenburg K. Bacterial cell wall compounds as promising targets of antimicrobial agents I. Antimicrobial peptides and lipopolyamines. Current Drug Targets. 13: 1121-30. PMID 22664072 DOI: 10.2174/138945012802002410 |
0.355 |
|
| 2012 |
Salunke DB, Shukla NM, Yoo E, Crall BM, Balakrishna R, Malladi SS, David SA. Structure-activity relationships in human Toll-like receptor 2-specific monoacyl lipopeptides. Journal of Medicinal Chemistry. 55: 3353-63. PMID 22385476 DOI: 10.1021/Jm3000533 |
0.774 |
|
| 2012 |
Shukla NM, Mutz CA, Malladi SS, Warshakoon HJ, Balakrishna R, David SA. Toll-like receptor (TLR)-7 and -8 modulatory activities of dimeric imidazoquinolines. Journal of Medicinal Chemistry. 55: 1106-16. PMID 22239408 DOI: 10.1021/Jm2010207 |
0.816 |
|
| 2012 |
Ukani R, Lewis TC, Day TP, Wu W, Malladi SS, Warshakoon HJ, David SA. Potent adjuvantic activity of a CCR1-agonistic bis-quinoline. Bioorganic & Medicinal Chemistry Letters. 22: 293-5. PMID 22104149 DOI: 10.1016/J.Bmcl.2011.11.014 |
0.42 |
|
| 2011 |
Agnihotri G, Crall BM, Lewis TC, Day TP, Balakrishna R, Warshakoon HJ, Malladi SS, David SA. Structure-activity relationships in toll-like receptor 2-agonists leading to simplified monoacyl lipopeptides. Journal of Medicinal Chemistry. 54: 8148-60. PMID 22007676 DOI: 10.1021/Jm201071E |
0.585 |
|
| 2011 |
Shukla NM, Malladi SS, Day V, David SA. Preliminary evaluation of a 3H imidazoquinoline library as dual TLR7/TLR8 antagonists. Bioorganic & Medicinal Chemistry. 19: 3801-11. PMID 21620714 DOI: 10.1016/J.Bmc.2011.04.052 |
0.792 |
|
| 2011 |
Shukla NM, Lewis TC, Day TP, Mutz CA, Ukani R, Hamilton CD, Balakrishna R, David SA. Toward self-adjuvanting subunit vaccines: model peptide and protein antigens incorporating covalently bound toll-like receptor-7 agonistic imidazoquinolines. Bioorganic & Medicinal Chemistry Letters. 21: 3232-6. PMID 21549593 DOI: 10.1016/J.Bmcl.2011.04.050 |
0.768 |
|
| 2011 |
Agnihotri G, Ukani R, Malladi SS, Warshakoon HJ, Balakrishna R, Wang X, David SA. Structure-activity relationships in nucleotide oligomerization domain 1 (Nod1) agonistic γ-glutamyldiaminopimelic acid derivatives. Journal of Medicinal Chemistry. 54: 1490-510. PMID 21299227 DOI: 10.1021/Jm101535E |
0.393 |
|
| 2011 |
Day TP, Sil D, Shukla NM, Anbanandam A, Day VW, David SA. Imbuing aqueous solubility to amphotericin B and nystatin with a vitamin. Molecular Pharmaceutics. 8: 297-301. PMID 21141891 DOI: 10.1021/Mp100363F |
0.681 |
|
| 2010 |
Shukla NM, Mutz CA, Ukani R, Warshakoon HJ, Moore DS, David SA. Syntheses of fluorescent imidazoquinoline conjugates as probes of Toll-like receptor 7. Bioorganic & Medicinal Chemistry Letters. 20: 6384-6. PMID 20933417 DOI: 10.1016/J.Bmcl.2010.09.093 |
0.75 |
|
| 2010 |
David SA, Sil D. Development of small-molecule endotoxin sequestering agents. Sub-Cellular Biochemistry. 53: 255-83. PMID 20593271 DOI: 10.1007/978-90-481-9078-2_12 |
0.415 |
|
| 2010 |
Shukla NM, Malladi SS, Mutz CA, Balakrishna R, David SA. Structure-activity relationships in human toll-like receptor 7-active imidazoquinoline analogues. Journal of Medicinal Chemistry. 53: 4450-65. PMID 20481492 DOI: 10.1021/Jm100358C |
0.819 |
|
| 2010 |
Hood JD, Warshakoon HJ, Kimbrell MR, Shukla NM, Malladi SS, Wang X, David SA. Immunoprofiling toll-like receptor ligands: Comparison of immunostimulatory and proinflammatory profiles in ex vivo human blood models. Human Vaccines. 6: 322-35. PMID 20372068 DOI: 10.4161/Hv.6.4.10866 |
0.818 |
|
| 2010 |
Wu W, Li R, Malladi SS, Warshakoon HJ, Kimbrell MR, Amolins MW, Ukani R, Datta A, David SA. Structure-activity relationships in toll-like receptor-2 agonistic diacylthioglycerol lipopeptides. Journal of Medicinal Chemistry. 53: 3198-213. PMID 20302301 DOI: 10.1021/Jm901839G |
0.578 |
|
| 2010 |
Reiff EA, Nair SK, Henri JT, Greiner JF, Reddy BS, Chakrasali R, David SA, Chiu TL, Amin EA, Himes RH, Vander Velde DG, Georg GI. Total synthesis and evaluation of C26-hydroxyepothilone D derivatives for photoaffinity labeling of beta-tubulin. The Journal of Organic Chemistry. 75: 86-94. PMID 19954175 DOI: 10.1021/Jo901752V |
0.333 |
|
| 2009 |
Adediran SA, Day TP, Sil D, Kimbrell MR, Warshakoon HJ, Malladi SS, David SA. Synthesis of a highly water-soluble derivative of amphotericin B with attenuated proinflammatory activity. Molecular Pharmaceutics. 6: 1582-90. PMID 19663403 DOI: 10.1021/Mp9001602 |
0.32 |
|
| 2009 |
Shrestha A, Sil D, Malladi SS, Warshakoon HJ, David SA. Structure-activity relationships of lipopolysaccharide sequestration in N-alkylpolyamines. Bioorganic & Medicinal Chemistry Letters. 19: 2478-81. PMID 19332373 DOI: 10.1016/J.Bmcl.2009.03.055 |
0.349 |
|
| 2009 |
Shukla NM, Kimbrell MR, Malladi SS, David SA. Regioisomerism-dependent TLR7 agonism and antagonism in an imidazoquinoline. Bioorganic & Medicinal Chemistry Letters. 19: 2211-4. PMID 19285861 DOI: 10.1016/J.Bmcl.2009.02.100 |
0.801 |
|
| 2009 |
Warshakoon HJ, Hood JD, Kimbrell MR, Malladi S, Wu WY, Shukla NM, Agnihotri G, Sil D, David SA. Potential adjuvantic properties of innate immune stimuli. Human Vaccines. 5: 381-94. PMID 19270494 DOI: 10.4161/Hv.5.6.8175 |
0.8 |
|
| 2009 |
Wu W, Sil D, Szostak ML, Malladi SS, Warshakoon HJ, Kimbrell MR, Cromer JR, David SA. Structure-activity relationships of lipopolysaccharide sequestration in guanylhydrazone-bearing lipopolyamines. Bioorganic & Medicinal Chemistry. 17: 709-15. PMID 19064323 DOI: 10.1016/J.Bmc.2008.11.051 |
0.479 |
|
| 2009 |
Warshakoon HJ, Burns MR, David SA. Structure-activity relationships of antimicrobial and lipoteichoic acid-sequestering properties in polyamine sulfonamides. Antimicrobial Agents and Chemotherapy. 53: 57-62. PMID 18955537 DOI: 10.1128/Aac.00812-08 |
0.496 |
|
| 2008 |
Nguyen TB, Kumar EV, Sil D, Wood SJ, Miller KA, Warshakoon HJ, Datta A, David SA. Controlling plasma protein binding: structural correlates of interactions of hydrophobic polyamine endotoxin sequestrants with human serum albumin. Molecular Pharmaceutics. 5: 1131-7. PMID 19434925 DOI: 10.1021/Mp8001123 |
0.398 |
|
| 2008 |
Kimbrell MR, Warshakoon H, Cromer JR, Malladi S, Hood JD, Balakrishna R, Scholdberg TA, David SA. Comparison of the immunostimulatory and proinflammatory activities of candidate Gram-positive endotoxins, lipoteichoic acid, peptidoglycan, and lipopeptides, in murine and human cells. Immunology Letters. 118: 132-41. PMID 18468694 DOI: 10.1016/J.Imlet.2008.03.009 |
0.497 |
|
| 2008 |
Bhunia A, Chua GL, Domadia PN, Warshakoon H, Cromer JR, David SA, Bhattacharjya S. Interactions of a designed peptide with lipopolysaccharide: Bound conformation and anti-endotoxic activity. Biochemical and Biophysical Research Communications. 369: 853-7. PMID 18328260 DOI: 10.1016/J.Bbrc.2008.02.105 |
0.365 |
|
| 2007 |
Nguyen TB, Adisechan AK, Suresh Kumar EV, Balakrishna R, Kimbrell MR, Miller KA, Datta A, David SA. Protection from endotoxic shock by EVK-203, a novel alkylpolyamine sequestrant of lipopolysaccharide. Bioorganic & Medicinal Chemistry. 15: 5694-709. PMID 17583517 DOI: 10.1016/J.Bmc.2007.06.015 |
0.441 |
|
| 2007 |
Sil D, Shrestha A, Kimbrell MR, Nguyen TB, Adisechan AK, Balakrishna R, Abbo BG, Malladi S, Miller KA, Short S, Cromer JR, Arora S, Datta A, David SA. Bound to shock: protection from lethal endotoxemic shock by a novel, nontoxic, alkylpolyamine lipopolysaccharide sequestrant. Antimicrobial Agents and Chemotherapy. 51: 2811-9. PMID 17548488 DOI: 10.1128/Aac.00200-07 |
0.436 |
|
| 2007 |
Bhattacharjya S, Domadia PN, Bhunia A, Malladi S, David SA. High-resolution solution structure of a designed peptide bound to lipopolysaccharide: transferred nuclear Overhauser effects, micelle selectivity, and anti-endotoxic activity. Biochemistry. 46: 5864-74. PMID 17469802 DOI: 10.1021/Bi6025159 |
0.38 |
|
| 2007 |
Burns MR, Jenkins SA, Kimbrell MR, Balakrishna R, Nguyen TB, Abbo BG, David SA. Polycationic sulfonamides for the sequestration of endotoxin. Journal of Medicinal Chemistry. 50: 877-88. PMID 17256835 DOI: 10.1021/Jm061198M |
0.459 |
|
| 2006 |
Laursen JB, Nielsen J, Haack T, Pusuluri S, David S, Balakrishna R, Zeng Y, Ma Z, Doyle TB, Mitscher LA. Further exploration of antimicrobial ketodihydronicotinic acid derivatives by multiple parallel syntheses. Combinatorial Chemistry & High Throughput Screening. 9: 663-81. PMID 17100572 DOI: 10.2174/138620706778700107 |
0.363 |
|
| 2006 |
Burns MR, Jenkins SA, Vermeulen NM, Balakrishna R, Nguyen TB, Kimbrell MR, David SA. Structural correlation between lipophilicity and lipopolysaccharide-sequestering activity in spermine-sulfonamide analogs. Bioorganic & Medicinal Chemistry Letters. 16: 6209-12. PMID 17010608 DOI: 10.1016/J.Bmcl.2006.09.026 |
0.385 |
|
| 2006 |
Balakrishna R, Wood SJ, Nguyen TB, Miller KA, Suresh Kumar EV, Datta A, David SA. Structural correlates of antibacterial and membrane-permeabilizing activities in acylpolyamines. Antimicrobial Agents and Chemotherapy. 50: 852-61. PMID 16495242 DOI: 10.1128/Aac.50.3.852-861.2006 |
0.412 |
|
| 2006 |
Wood SJ, Miller KA, Lushington GH, Burns MR, David SA. Anti-endotoxin agents. 3. Rapid identification of high-affinity lipopolysaccharide-binding compounds in a substituted polyamine library. Combinatorial Chemistry & High Throughput Screening. 9: 27-36. PMID 16454684 DOI: 10.2174/138620706775213903 |
0.42 |
|
| 2006 |
Burns MR, Jenkins SA, Wood SJ, Miller K, David SA. Structure-activity relationships in lipopolysaccharide neutralizers: design, synthesis, and biological evaluation of a 540-membered amphipathic bisamide library. Journal of Combinatorial Chemistry. 8: 32-43. PMID 16398551 DOI: 10.1021/Cc0500755 |
0.408 |
|
| 2006 |
Khownium K, Wood SJ, Miller KA, Balakrishna R, Nguyen TB, Kimbrell MR, Georg GI, David SA. Novel endotoxin-sequestering compounds with terephthalaldehyde-bis-guanylhydrazone scaffolds. Bioorganic & Medicinal Chemistry Letters. 16: 1305-8. PMID 16377188 DOI: 10.1016/J.Bmcl.2005.11.059 |
0.422 |
|
| 2006 |
Guo JX, Wood SJ, David SA, Lushington GH. Molecular modeling analysis of the interaction of novel bis-cationic ligands with the lipid A moiety of lipopolysaccharide. Bioorganic & Medicinal Chemistry Letters. 16: 714-7. PMID 16266804 DOI: 10.1016/J.Bmcl.2005.10.025 |
0.411 |
|
| 2005 |
Miller KA, Suresh Kumar EV, Wood SJ, Cromer JR, Datta A, David SA. Lipopolysaccharide sequestrants: structural correlates of activity and toxicity in novel acylhomospermines. Journal of Medicinal Chemistry. 48: 2589-99. PMID 15801849 DOI: 10.1021/Jm049449J |
0.458 |
|
| 2005 |
Burns MR, Wood SJ, Miller KA, Nguyen T, Cromer JR, David SA. Lysine-spermine conjugates: hydrophobic polyamine amides as potent lipopolysaccharide sequestrants. Bioorganic & Medicinal Chemistry. 13: 2523-36. PMID 15755654 DOI: 10.1016/J.Bmc.2005.01.038 |
0.422 |
|
| 2005 |
Cromer JR, Wood SJ, Miller KA, Nguyen T, David SA. Functionalized dendrimers as endotoxin sponges. Bioorganic & Medicinal Chemistry Letters. 15: 1295-8. PMID 15713373 DOI: 10.1016/J.Bmcl.2005.01.026 |
0.436 |
|
| 2004 |
Wood SJ, Miller KA, David SA. Anti-endotoxin agents. 2. Pilot high-throughput screening for novel lipopolysaccharide-recognizing motifs in small molecules. Combinatorial Chemistry & High Throughput Screening. 7: 733-47. PMID 15578935 DOI: 10.2174/1386207043328229 |
0.385 |
|
| 2004 |
Wood SJ, Miller KA, David SA. Anti-endotoxin agents. 1. Development of a fluorescent probe displacement method optimized for the rapid identification of lipopolysaccharide-binding agents. Combinatorial Chemistry & High Throughput Screening. 7: 239-49. PMID 15134530 DOI: 10.2174/1386207043328832 |
0.427 |
|
| 2002 |
David S, Pérez L, Infante MR. Sequestration of bacterial lipopolysaccharide by bis(Args) gemini compounds Bioorganic & Medicinal Chemistry Letters. 12: 357-360. PMID 11814796 DOI: 10.1016/S0960-894X(01)00749-1 |
0.382 |
|
| 2001 |
David SA. Towards a rational development of anti-endotoxin agents: novel approaches to sequestration of bacterial endotoxins with small molecules. Journal of Molecular Recognition : Jmr. 14: 370-87. PMID 11757070 DOI: 10.1002/Jmr.549 |
0.413 |
|
| 2000 |
David SA, Awasthi SK, Balaram P. The role of polar and facial amphipathic character in determining lipopolysaccharide-binding properties in synthetic cationic peptides. Journal of Endotoxin Research. 6: 249-56. PMID 11052180 DOI: 10.1177/09680519000060030601 |
0.371 |
|
| 2000 |
Blagbrough IS, Geall AJ, David SA. Lipopolyamines incorporating the tetraamine spermine, bound to an alkyl chain, sequester bacterial lipopolysaccharide. Bioorganic & Medicinal Chemistry Letters. 10: 1959-62. PMID 10987426 DOI: 10.1016/S0960-894X(00)00380-2 |
0.32 |
|
| 1999 |
David SA, Silverstein R, Amura CR, Kielian T, Morrison DC. Lipopolyamines: novel antiendotoxin compounds that reduce mortality in experimental sepsis caused by gram-negative bacteria. Antimicrobial Agents and Chemotherapy. 43: 912-9. PMID 10103199 DOI: 10.1128/Aac.43.4.912 |
0.442 |
|
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