☰

Rakesh K. Jain - Publications

Affiliations: 
1976-1983 Chemical and Biomedical Engineering Columbia University, New York, NY 
 1983-1991 Chemical and Biomedical Engineering Carnegie Mellon University, Pittsburgh, PA 
 1991- Engineering and Applied Sciences Harvard Medical School, Boston, MA, United States 
Area:
Biomedical Engineering
Website:
https://steelelabs.mgh.harvard.edu/rakesh_jain#pi_bio
Tree Info Similar researchers PubMed Report error

449 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Datta M, Chatterjee S, Perez EM, Gritsch S, Roberge S, Duquette M, Chen IX, Naxerova K, Kumar AS, Ghosh M, Emblem KE, Ng MR, Ho WW, Kumar P, Krishnan S, ... ... Jain RK, et al. Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models. Proceedings of the National Academy of Sciences of the United States of America. 120: e2219199120. PMID 36724255 DOI: 10.1073/pnas.2219199120  0.651
2022 Martin JD, Lanning RM, Chauhan VP, Martin MR, Mousa AS, Kamoun WS, Han HS, Lee H, Stylianopoulos T, Bawendi MG, Duda DG, Brown EB, Padera TP, Fukumura D, Jain RK. Multiphoton phosphorescence quenching microscopy reveals kinetics of tumor oxygenation during anti-angiogenesis and angiotensin signaling inhibition. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 35584239 DOI: 10.1158/1078-0432.CCR-22-0486  0.625
2022 Ferraro GB, Ali A, Luengo A, Kodack DP, Deik A, Abbott KL, Bezwada D, Blanc L, Prideaux B, Jin X, Posada JM, Chen J, Chin CR, Amoozgar Z, Ferreira R, ... ... Jain RK, et al. Author Correction: Fatty acid synthesis is required for breast cancer brain metastasis. Nature Cancer. 2: 1243. PMID 35122065 DOI: 10.1038/s43018-021-00283-9  0.61
2021 Ho WW, Gomes-Santos IL, Aoki S, Datta M, Kawaguchi K, Talele NP, Roberge S, Ren J, Liu H, Chen IX, Andersson P, Chatterjee S, Kumar AS, Amoozgar Z, Zhang Q, ... ... Jain RK, et al. Dendritic cell paucity in mismatch repair-proficient colorectal cancer liver metastases limits immune checkpoint blockade efficacy. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34725151 DOI: 10.1073/pnas.2105323118  0.617
2021 Ferraro GB, Ali A, Luengo A, Kodack DP, Deik A, Abbott KL, Bezwada D, Blanc L, Prideaux B, Jin X, Possada JM, Chen J, Chin CR, Amoozgar Z, Ferreira R, ... ... Jain RK, et al. FATTY ACID SYNTHESIS IS REQUIRED FOR BREAST CANCER BRAIN METASTASIS. Nature Cancer. 2: 414-428. PMID 34179825 DOI: 10.1038/s43018-021-00183-y  0.64
2021 Aoki S, Inoue K, Klein S, Halvorsen S, Chen J, Matsui A, Nikmaneshi MR, Kitahara S, Hato T, Chen X, Kawakubo K, Nia HT, Chen I, Schanne DH, Mamessier E, ... ... Jain RK, et al. Placental growth factor promotes tumour desmoplasia and treatment resistance in intrahepatic cholangiocarcinoma. Gut. PMID 33431577 DOI: 10.1136/gutjnl-2020-322493  0.633
2020 Nia HT, Munn LL, Jain RK. Physical traits of cancer. Science (New York, N.Y.). 370. PMID 33122355 DOI: 10.1126/science.aaz0868  0.678
2020 Chen IX, Newcomer K, Pauken KE, Juneja VR, Naxerova K, Wu MW, Pinter M, Sen DR, Singer M, Sharpe AH, Jain RK. A bilateral tumor model identifies transcriptional programs associated with patient response to immune checkpoint blockade. Proceedings of the National Academy of Sciences of the United States of America. PMID 32907939 DOI: 10.1073/Pnas.2002806117  0.691
2020 Nia HT, Datta M, Seano G, Zhang S, Ho WW, Roberge S, Huang P, Munn LL, Jain RK. In vivo compression and imaging in mouse brain to measure the effects of solid stress. Nature Protocols. PMID 32681151 DOI: 10.1038/S41596-020-0328-2  0.697
2020 Valiente M, Van Swearingen AED, Anders CK, Bairoch A, Boire A, Bos PD, Cittelly DM, Erez N, Ferraro GB, Fukumura D, Gril B, Herlyn M, Holmen SL, Jain RK, Joyce JA, et al. Brain Metastasis Cell Lines Panel: a public resource of organotropic cell lines. Cancer Research. PMID 32641416 DOI: 10.1158/0008-5472.Can-20-0291  0.309
2020 Ngo B, Kim E, Osorio-Vasquez V, Doll S, Bustraan S, Liang RJ, Luengo A, Davidson SM, Ali A, Ferraro GB, Fischer GM, Eskandari R, Kang DS, Ni J, Plasger A, ... ... Jain RK, et al. Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition. Cancer Discovery. PMID 32571778 DOI: 10.1158/2159-8290.Cd-19-1228  0.342
2020 Millar DG, Ramjiawan RR, Kawaguchi K, Gupta N, Chen J, Zhang S, Nojiri T, Ho WW, Aoki S, Jung K, Chen I, Shi F, Heather JM, Shigeta K, Morton LT, ... ... Jain RK, et al. Antibody-mediated delivery of viral epitopes to tumors harnesses CMV-specific T cells for cancer therapy. Nature Biotechnology. PMID 32042168 DOI: 10.1038/S41587-019-0404-8  0.353
2020 Martin JD, Cabral H, Stylianopoulos T, Jain RK. Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges. Nature Reviews. Clinical Oncology. PMID 32034288 DOI: 10.1038/S41571-019-0308-Z  0.319
2020 Mpekris F, Voutouri C, Baish JW, Duda DG, Munn LL, Stylianopoulos T, Jain RK. Combining microenvironment normalization strategies to improve cancer immunotherapy. Proceedings of the National Academy of Sciences of the United States of America. PMID 32015113 DOI: 10.1073/Pnas.1919764117  0.409
2020 Sahai E, Astsaturov I, Cukierman E, DeNardo DG, Egeblad M, Evans RM, Fearon D, Greten FR, Hingorani SR, Hunter T, Hynes RO, Jain RK, Janowitz T, Jorgensen C, Kimmelman AC, et al. A framework for advancing our understanding of cancer-associated fibroblasts. Nature Reviews. Cancer. PMID 31980749 DOI: 10.1038/S41568-019-0238-1  0.3
2019 Flores-Toro JA, Luo D, Gopinath A, Sarkisian MR, Campbell JJ, Charo IF, Singh R, Schall TJ, Datta M, Jain RK, Mitchell DA, Harrison JK. CCR2 inhibition reduces tumor myeloid cells and unmasks a checkpoint inhibitor effect to slow progression of resistant murine gliomas. Proceedings of the National Academy of Sciences of the United States of America. PMID 31879345 DOI: 10.1073/Pnas.1910856117  0.305
2019 Seano G, Jain RK. Vessel co-option in glioblastoma: emerging insights and opportunities. Angiogenesis. PMID 31679081 DOI: 10.1007/S10456-019-09691-Z  0.326
2019 Arvanitis CD, Ferraro GB, Jain RK. The blood-brain barrier and blood-tumour barrier in brain tumours and metastases. Nature Reviews. Cancer. PMID 31601988 DOI: 10.1038/S41568-019-0205-X  0.306
2019 Gerstner E, Emblem KE, Chang K, Vakulenko-Lagun B, Yen YF, Beers AL, Dietrich J, Plotkin SR, Catana C, Hooker JM, Duda DG, Rosen B, Kalpathy-Cramer J, Jain RK, Batchelor T. Bevacizumab reduces permeability and concurrent temozolomide delivery in a subset of patients with recurrent glioblastoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31558474 DOI: 10.1158/1078-0432.Ccr-19-1739  0.376
2019 Shigeta K, Datta M, Hato T, Kitahara S, Chen IX, Matsui A, Kikuchi H, Mamessier E, Aoki S, Ramjiawan RR, Ochiai H, Bardeesy N, Huang P, Jain RK, Cobbold M, et al. Dual PD-1 and VEGFR-2 blockade promotes vascular normalization and enhances anti-tumor immune responses in HCC. Hepatology (Baltimore, Md.). PMID 31378984 DOI: 10.1002/Hep.30889  0.32
2019 Amoozgar Z, Jain RK, Duda DG. Role of Apelin in Glioblastoma Vascularization and Invasion after Anti-VEGF Therapy: What Is the Impact on the Immune System? Cancer Research. 79: 2104-2106. PMID 31043429 DOI: 10.1158/0008-5472.Can-19-0749  0.312
2019 Chauhan VP, Chen IX, Tong R, Ng MR, Martin JD, Naxerova K, Wu MW, Huang P, Boucher Y, Kohane DS, Langer R, Jain RK. Reprogramming the microenvironment with tumor-selective angiotensin blockers enhances cancer immunotherapy. Proceedings of the National Academy of Sciences of the United States of America. PMID 31040208 DOI: 10.1073/Pnas.1819889116  0.783
2019 Seano G, Nia HT, Emblem KE, Datta M, Ren J, Krishnan S, Kloepper J, Pinho MC, Ho WW, Ghosh M, Askoxylakis V, Ferraro GB, Riedemann L, Gerstner ER, Batchelor TT, ... ... Jain RK, et al. Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium. Nature Biomedical Engineering. 3: 230-245. PMID 30948807 DOI: 10.1038/S41551-018-0334-7  0.721
2019 Martin JD, Seano G, Jain RK. Normalizing Function of Tumor Vessels: Progress, Opportunities, and Challenges. Annual Review of Physiology. 81: 505-534. PMID 30742782 DOI: 10.1146/Annurev-Physiol-020518-114700  0.396
2019 Chen IX, Chauhan VP, Posada J, Ng MR, Wu MW, Adstamongkonkul P, Huang P, Lindeman N, Langer R, Jain RK. Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 30700545 DOI: 10.1073/Pnas.1815515116  0.663
2019 Voutouri C, Kirkpatrick ND, Chung E, Mpekris F, Baish JW, Munn LL, Fukumura D, Stylianopoulos T, Jain RK. Experimental and computational analyses reveal dynamics of tumor vessel cooption and optimal treatment strategies. Proceedings of the National Academy of Sciences of the United States of America. PMID 30700544 DOI: 10.1073/Pnas.1818322116  0.429
2019 Zhao Y, Cao J, Melamed A, Worley M, Gockley A, Jones D, Nia HT, Zhang Y, Stylianopoulos T, Kumar AS, Mpekris F, Datta M, Sun Y, Wu L, Gao X, ... ... Jain RK, et al. Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma. Proceedings of the National Academy of Sciences of the United States of America. PMID 30659155 DOI: 10.1073/Pnas.1818357116  0.714
2019 Nia HT, Munn LL, Jain RK. Mapping physical tumor microenvironment and drug delivery. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30630829 DOI: 10.1158/1078-0432.Ccr-18-3724  0.685
2019 Chen J, Landegger LD, Sun Y, Ren J, Maimon N, Wu L, Ng MR, Chen JW, Zhang N, Zhao Y, Gao X, Fujita T, Roberge S, Huang P, Jain RK, et al. A cerebellopontine angle mouse model for the investigation of tumor biology, hearing, and neurological function in NF2-related vestibular schwannoma. Nature Protocols. PMID 30617350 DOI: 10.1038/S41596-018-0105-7  0.337
2019 Talele NP, Liu H, Naxerova K, Pinter M, Incio J, Lee H, Shigeta K, Ho WW, Michelakos T, Hong TS, Clark JW, Murphy JE, Ryan DP, Deshpande V, Lillemoe KD, ... ... Jain R, et al. Abstract A115: Use of angiotensin system inhibitors is associated with immune activation and longer survival in pancreatic ductal adenocarcinoma patients Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-A115  0.66
2019 Chen IX, Chauhan VP, Posada J, Ng MR, Wu M, Adstamongkonkul P, Huang P, Lindeman N, Langer R, Jain RK. Abstract 2744: Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-2744  0.627
2019 Grahovac J, Han S, Liu H, Duquette M, Luengo A, Schanne D, Liss AS, Heiden MGV, Jain RK, Boucher Y. Abstract B06: The angiotensin receptor blocker and partial PPARγ agonist telmisartan inhibits the growth of pancreatic ductal adenocarcinoma Cancer Research. 79. DOI: 10.1158/1538-7445.Panca19-B06  0.314
2019 Liu H, Ho WW, Naxerova K, Grahovac J, Nia H, Chen I, Posada JM, Schanne DH, Pinter M, Crain J, Qi X, Clark JW, Hong TS, Ryan DP, Huang P, ... ... Jain RK, et al. Abstract A18: Angiotensin receptor blockers normalize the pancreatic ductal adenocarcinoma stroma by reprogramming carcinoma-associated fibroblasts Cancer Research. 79. DOI: 10.1158/1538-7445.Panca19-A18  0.787
2019 Jain RK. Abstract SY33-01: Improving immunotherapy of cancer by normalizing tumor vessels Cancer Research. 79. DOI: 10.1158/1538-7445.Am2019-Sy33-01  0.411
2019 Ferraro G, Arvanitis C, Askoxylakis V, Guo Y, Datta M, Bernabeu M, Fukumura D, McDannold N, Jain R. BSCI-09. MECHANISMS OF ENHANCED DRUG DELIVERY IN BRAIN METASTASES WITH FOCUSED ULTRASOUND-INDUCED BLOOD-TUMOR BARRIER DISRUPTION Neuro-Oncology Advances. 1: i2-i2. DOI: 10.1093/noajnl/vdz014.007  0.532
2019 Seano G, Griveau A, Shelton S, Krishnan S, Wang N, Kloepper J, Huillard E, Batchelor T, Stemmer-Rachamimov A, Aghi M, Jain R, Rowitch D. OS12.4 In vivo dynamics and targeting of vessel co-option in glioma Neuro-Oncology. 21: iii23-iii23. DOI: 10.1093/Neuonc/Noz126.076  0.353
2018 Keklikoglou I, Cianciaruso C, Güç E, Squadrito ML, Spring LM, Tazzyman S, Lambein L, Poissonnier A, Ferraro GB, Baer C, Cassará A, Guichard A, Iruela-Arispe ML, Lewis CE, Coussens LM, ... ... Jain RK, et al. Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models. Nature Cell Biology. PMID 30598531 DOI: 10.1038/S41556-018-0256-3  0.323
2018 Ina Ly K, Vakulenko-Lagun B, Emblem KE, Ou Y, Da X, Betensky RA, Kalpathy-Cramer J, Duda DG, Jain RK, Chi AS, Plotkin SR, Batchelor TT, Sorensen G, Rosen BR, Gerstner ER. Probing tumor microenvironment in patients with newly diagnosed glioblastoma during chemoradiation and adjuvant temozolomide with functional MRI. Scientific Reports. 8: 17062. PMID 30459364 DOI: 10.1038/S41598-018-34820-X  0.356
2018 Liao S, Bouta EM, Morris LM, Jones D, Jain RK, Padera TP. Inducible Nitric Oxide Synthase and CD11bGr1 Cells Impair Lymphatic Contraction of Tumor-Draining Lymphatic Vessels. Lymphatic Research and Biology. PMID 30358484 DOI: 10.1089/Lrb.2018.0013  0.367
2018 Khandekar MJ, Jain R. Smooth sailing for immunotherapy for unresectable stage III non-small cell lung cancer: the PACIFIC study. Translational Cancer Research. 7: S16-S20. PMID 30175050 DOI: 10.21037/Tcr.2017.12.17  0.373
2018 Arvanitis CD, Askoxylakis V, Guo Y, Datta M, Kloepper J, Ferraro GB, Bernabeu MO, Fukumura D, McDannold N, Jain RK. Mechanisms of enhanced drug delivery in brain metastases with focused ultrasound-induced blood-tumor barrier disruption. Proceedings of the National Academy of Sciences of the United States of America. PMID 30150398 DOI: 10.1073/Pnas.1807105115  0.579
2018 Grassberger C, Hong TS, Hato T, Yeap BY, Wo JY, Tracy M, Bortfeld T, Wolfgang JA, Eyler CE, Goyal L, Clark JW, Crane CH, Koay EJ, Cobbold M, DeLaney TF, ... Jain RK, et al. Differential Association Between Circulating Lymphocyte Populations With Outcome After Radiation Therapy in Subtypes of Liver Cancer. International Journal of Radiation Oncology, Biology, Physics. PMID 29859792 DOI: 10.1016/J.Ijrobp.2018.04.026  0.32
2018 Nowak-Sliwinska P, Alitalo K, Allen E, Anisimov A, Aplin AC, Auerbach R, Augustin HG, Bates DO, van Beijnum JR, Bender RHF, Bergers G, Bikfalvi A, Bischoff J, Böck BC, Brooks PC, ... ... Jain RK, et al. Consensus guidelines for the use and interpretation of angiogenesis assays. Angiogenesis. PMID 29766399 DOI: 10.1007/S10456-018-9613-X  0.303
2018 Binnewies M, Roberts EW, Kersten K, Chan V, Fearon DF, Merad M, Coussens LM, Gabrilovich DI, Ostrand-Rosenberg S, Hedrick CC, Vonderheide RH, Pittet MJ, Jain RK, Zou W, Howcroft TK, et al. Understanding the tumor immune microenvironment (TIME) for effective therapy. Nature Medicine. PMID 29686425 DOI: 10.1038/S41591-018-0014-X  0.356
2018 Griveau A, Seano G, Shelton SJ, Kupp R, Jahangiri A, Obernier K, Krishnan S, Lindberg OR, Yuen TJ, Tien AC, Sabo JK, Wang N, Chen I, Kloepper J, Larrouquere L, ... ... Jain RK, et al. A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment. Cancer Cell. PMID 29681511 DOI: 10.1016/J.Ccell.2018.03.020  0.354
2018 Nia HT, Datta M, Seano G, Huang P, Munn LL, Jain RK. Quantifying solid stress and elastic energy from excised or in situ tumors. Nature Protocols. 13: 1091-1105. PMID 29674756 DOI: 10.1038/Nprot.2018.020  0.702
2018 Stylianopoulos T, Munn LL, Jain RK. Reengineering the Physical Microenvironment of Tumors to Improve Drug Delivery and Efficacy: From Mathematical Modeling to Bench to Bedside. Trends in Cancer. 4: 292-319. PMID 29606314 DOI: 10.1016/J.Trecan.2018.02.005  0.4
2018 Stylianopoulos T, Munn LL, Jain RK. Reengineering the Tumor Vasculature: Improving Drug Delivery and Efficacy. Trends in Cancer. 4: 258-259. PMID 29606306 DOI: 10.1016/J.Trecan.2018.02.010  0.423
2018 Incio J, Ligibel JA, McManus DT, Suboj P, Jung K, Kawaguchi K, Pinter M, Babykutty S, Chin SM, Vardam TD, Huang Y, Rahbari NN, Roberge S, Wang D, Gomes-Santos IL, ... ... Jain RK, et al. Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2. Science Translational Medicine. 10. PMID 29540614 DOI: 10.1126/Scitranslmed.Aag0945  0.341
2018 Fukumura D, Kloepper J, Amoozgar Z, Duda DG, Jain RK. Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges. Nature Reviews. Clinical Oncology. PMID 29508855 DOI: 10.1038/Nrclinonc.2018.29  0.306
2018 Zhao Y, Liu P, Zhang N, Chen J, Landegger LD, Wu L, Zhao F, Zhao Y, Zhang Y, Zhang J, Fujita T, Stemmer-Rachamimov A, Ferraro GB, Liu H, Muzikansky A, ... ... Jain RK, et al. Targeting the cMET pathway augments radiation response without adverse effect on hearing in NF2 schwannoma models. Proceedings of the National Academy of Sciences of the United States of America. PMID 29440379 DOI: 10.1073/Pnas.1719966115  0.323
2018 Murphy JE, Wo JY, Ryan DP, Jiang W, Yeap BY, Duda GD, Allen JN, Blaszkowsky LS, Ferrone C, Parikh AR, Nipp RD, Zhu AX, Goyal L, Lillemoe KD, DeLaney TF, ... Jain RK, et al. Potentially curative combination of TGF-b1 inhibitor losartan and FOLFIRINOX (FFX) for locally advanced pancreatic cancer (LAPC): R0 resection rates and preliminary survival data from a prospective phase II study. Journal of Clinical Oncology. 36: 4116-4116. DOI: 10.1200/Jco.2018.36.15_Suppl.4116  0.302
2018 Jain RK. Abstract SY38-03: Microenvironment dictates differential responseof primary tumor versus metastases Tumor Biology. DOI: 10.1158/1538-7445.Am2018-Sy38-03  0.339
2018 Ng MR, Sabbatino F, Duquette M, Naxerova K, Badeaux M, Ferraro GB, Chin SM, Bezwada D, Brachtel EF, Ferrone S, Jain RK. Abstract LB-057: Hypoxia regulation of antigen presentation machinery expression in breast cancer Tumor Biology. DOI: 10.1158/1538-7445.Am2018-Lb-057  0.638
2018 Arvanitis C, Askoxylakis V, Guo Y, Datta M, Kloepper J, Ferraro G, Bernabeu M, Fukumura D, McDannold N, Jain R. CADD-32. MECHANISMS OF ENHANCED DRUG DELIVERY IN BRAIN TUMORS WITH FOCUSED ULTRASOUND-INDUCED TRANSIENT BLOOD-TUMOR BARRIER DISRUPTION Neuro-Oncology. 20: vi281-vi281. DOI: 10.1093/Neuonc/Noy148.1172  0.585
2017 Kozin SV, Maimon N, Wang R, Gupta N, Munn L, Jain RK, Garkavtsev I. Secretory leukocyte protease inhibitor (SLPI) as a potential target for inhibiting metastasis of triple-negative breast cancers. Oncotarget. 8: 108292-108302. PMID 29312532 DOI: 10.18632/Oncotarget.22660  0.375
2017 Reardon DA, Lassman AB, Schiff D, Yunus SA, Gerstner ER, Cloughesy TF, Lee EQ, Gaffey SC, Barrs J, Bruno J, Muzikansky A, Duda DG, Jain RK, Wen PY. Phase 2 and biomarker study of trebananib, an angiopoietin-blocking peptibody, with and without bevacizumab for patients with recurrent glioblastoma. Cancer. PMID 29266174 DOI: 10.1002/Cncr.31172  0.322
2017 Li W, Liu Y, Yang W, Han X, Li S, Liu H, Gerweck LE, Fukumura D, Loeffler JS, Yang BB, Jain RK, Huang P. MicroRNA-378 enhances radiation response in ectopic and orthotopic implantation models of glioblastoma. Journal of Neuro-Oncology. PMID 29081036 DOI: 10.1007/S11060-017-2646-Y  0.328
2017 Pinter M, Jain RK. Targeting the renin-angiotensin system to improve cancer treatment: Implications for immunotherapy. Science Translational Medicine. 9. PMID 28978752 DOI: 10.1126/Scitranslmed.Aan5616  0.37
2017 Zhang N, Chen J, Ferraro G, Wu L, Datta M, Jain RK, Plotkin SR, Stemmer-Rachamimov A, Xu L. Anti-VEGF treatment improves neurological function in tumors of the nervous system. Experimental Neurology. PMID 28911884 DOI: 10.1016/J.Expneurol.2017.09.008  0.34
2017 Jung K, Heishi T, Incio J, Huang Y, Beech EY, Pinter M, Ho WW, Kawaguchi K, Rahbari NN, Chung E, Kim JK, Clark JW, Willett CG, Yun SH, Luster AD, ... ... Jain RK, et al. Targeting CXCR4-dependent immunosuppressive Ly6C(low) monocytes improves antiangiogenic therapy in colorectal cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 28900008 DOI: 10.1073/Pnas.1710754114  0.351
2017 Jung K, Heishi T, Khan OF, Kowalski PS, Incio J, Rahbari NN, Chung E, Clark JW, Willett CG, Luster AD, Yun SH, Langer R, Anderson DG, Padera TP, Jain RK, et al. Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy. The Journal of Clinical Investigation. PMID 28691930 DOI: 10.1172/Jci93182  0.39
2017 Naxerova K, Reiter JG, Brachtel E, Lennerz JK, van de Wetering M, Rowan A, Cai T, Clevers H, Swanton C, Nowak MA, Elledge SJ, Jain RK. Origins of lymphatic and distant metastases in human colorectal cancer. Science (New York, N.Y.). 357: 55-60. PMID 28684519 DOI: 10.1126/Science.Aai8515  0.664
2017 Askoxylakis V, Arvanitis CD, Wong CSF, Ferraro GB, Jain RK. Emerging Strategies for Delivering Antiangiogenic Therapies to Primary and Metastatic Brain Tumors. Advanced Drug Delivery Reviews. PMID 28648712 DOI: 10.1016/J.Addr.2017.06.011  0.36
2017 Liu H, Naxerova K, Pinter M, Incio J, Lee H, Shigeta K, Ho WW, Crain JA, Jacobson A, Michelakos T, Dias-Santos D, Zanconato A, Hong TS, Clark JW, Murphy JE, ... ... Jain RK, et al. Use of Angiotensin System Inhibitors is Associated with Immune Activation and Longer Survival in Non-Metastatic Pancreatic Ductal Adenocarcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 28600474 DOI: 10.1158/1078-0432.Ccr-17-0256  0.655
2017 Kodack DP, Askoxylakis V, Ferraro GB, Sheng Q, Badeaux M, Goel S, Qi X, Shankaraiah R, Cao ZA, Ramjiawan RR, Bezwada D, Patel B, Song Y, Costa C, Naxerova K, ... ... Jain RK, et al. The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation. Science Translational Medicine. 9. PMID 28539475 DOI: 10.1126/Scitranslmed.Aal4682  0.661
2017 De Palma M, Jain RK. CD4(+) T Cell Activation and Vascular Normalization: Two Sides of the Same Coin? Immunity. 46: 773-775. PMID 28514684 DOI: 10.1016/J.Immuni.2017.04.015  0.304
2017 Mpekris F, Baish JW, Stylianopoulos T, Jain RK. Role of vascular normalization in benefit from metronomic chemotherapy. Proceedings of the National Academy of Sciences of the United States of America. PMID 28174262 DOI: 10.1073/Pnas.1700340114  0.409
2017 Gupta N, Badeaux M, Liu Y, Naxerova K, Sgroi D, Munn LL, Jain RK, Garkavtsev I. Stress granule-associated protein G3BP2 regulates breast tumor initiation. Proceedings of the National Academy of Sciences of the United States of America. PMID 28096337 DOI: 10.1073/Pnas.1525387114  0.679
2017 Wang N, Jain RK, Batchelor TT. New Directions in Anti-Angiogenic Therapy for Glioblastoma. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 28083806 DOI: 10.1007/S13311-016-0510-Y  0.349
2017 Rahbari NN, Kedrin D, Incio J, Liu H, Ho WT, Nia HT, Edrich CM, Jung K, Daubriac J, Chen I, Heishi T, Martin J, Huang Y, Maimon N, Reissfelder C, ... ... Jain RK, et al. Abstract PR06: VEGF-targeted therapy induces extracellular matrix remodeling and increases mechanical barriers to therapy in colorectal cancer liver metastases Cancer Research. 77. DOI: 10.1158/1538-7445.Epso16-Pr06  0.752
2017 Jain RK. Abstract IA01: Reengineering the tumor microenvironment to improve cancer treatment: Bench to bedside Cancer Research. 77. DOI: 10.1158/1538-7445.Epso16-Ia01  0.434
2017 Ferraro GB, Kodack DP, Askoxylakis V, Sheng Q, Badeaux M, Goel S, Qi X, Shankaraiah R, Cao AZ, Ramjiawan RR, Bezwada D, Patel B, Song Y, Costa C, Naxerova K, ... ... Jain RK, et al. Abstract 5008: The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation Cancer Research. 77: 5008-5008. DOI: 10.1158/1538-7445.Am2017-5008  0.666
2017 Nia H, Liu H, Seano G, Datta M, Jones D, Rahbari N, Incio J, Chauhan V, Jung K, Martin J, Askoxylakis V, Padera T, Fukumura D, Boucher Y, Hornicek F, ... ... Jain R, et al. Abstract 3987: Solid stress and elastic energy as measures of tumor mechanopathology Cancer Research. 77: 3987-3987. DOI: 10.1158/1538-7445.Am2017-3987  0.798
2016 Nia HT, Liu H, Seano G, Datta M, Jones D, Rahbari N, Incio J, Chauhan VP, Jung K, Martin JD, Askoxylakis V, Padera TP, Fukumura D, Boucher Y, Hornicek FJ, ... ... Jain RK, et al. Solid stress and elastic energy as measures of tumour mechanopathology. Nature Biomedical Engineering. 1. PMID 28966873 DOI: 10.1038/S41551-016-0004  0.773
2016 Martin JD, Fukumura D, Duda DG, Boucher Y, Jain RK. Corrigendum: Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity. Cold Spring Harbor Perspectives in Medicine. 6. PMID 27908927 DOI: 10.1101/Cshperspect.A031195  0.386
2016 Hajjarian Z, Nia HT, Ahn S, Grodzinsky AJ, Jain RK, Nadkarni SK. Laser Speckle Rheology for evaluating the viscoelastic properties of hydrogel scaffolds. Scientific Reports. 6: 37949. PMID 27905494 DOI: 10.1038/Srep37949  0.7
2016 Kalpathy-Cramer J, Chandra V, Da X, Ou Y, Emblem KE, Muzikansky A, Cai X, Douw L, Evans JG, Dietrich J, Chi AS, Wen PY, Stufflebeam S, Rosen B, Duda DG, ... Jain RK, et al. Phase II study of tivozanib, an oral VEGFR inhibitor, in patients with recurrent glioblastoma. Journal of Neuro-Oncology. PMID 27853960 DOI: 10.1007/S11060-016-2332-5  0.382
2016 Tolaney SM, Ziehr DR, Guo H, Ng MR, Barry WT, Higgins MJ, Isakoff SJ, Brock JE, Ivanova EV, Paweletz CP, Demeo MK, Ramaiya NH, Overmoyer BA, Jain RK, Winer EP, et al. Phase II and Biomarker Study of Cabozantinib in Metastatic Triple-Negative Breast Cancer Patients. The Oncologist. PMID 27789775 DOI: 10.1634/Theoncologist.2016-0229  0.303
2016 Kumar V, Boucher Y, Liu H, Ferreira D, Hooker J, Catana C, Hoover AJ, Ritter T, Jain RK, Guimaraes AR. Noninvasive Assessment of Losartan-Induced Increase in Functional Microvasculature and Drug Delivery in Pancreatic Ductal Adenocarcinoma. Translational Oncology. 9: 431-437. PMID 27751347 DOI: 10.1016/J.Tranon.2016.07.004  0.302
2016 Rahbari NN, Kedrin D, Incio J, Liu H, Ho WW, Nia HT, Edrich CM, Jung K, Daubriac J, Chen I, Heishi T, Martin JD, Huang Y, Maimon N, Reissfelder C, ... ... Jain RK, et al. Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases. Science Translational Medicine. 8: 360ra135. PMID 27733559 DOI: 10.1126/Scitranslmed.Aaf5219  0.738
2016 Martin JD, Fukumura D, Duda DG, Boucher Y, Jain RK. Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity. Cold Spring Harbor Perspectives in Medicine. PMID 27663981 DOI: 10.1101/Cshperspect.A027094  0.424
2016 Menter AR, Carroll NM, Sakoda LC, Delate T, Hornbrook MC, Jain RK, Kushi LH, Quinn VP, Ritzwoller DP. Effect of Angiotensin System Inhibitors on Survival in Patients Receiving Chemotherapy for Advanced Non-Small-Cell Lung Cancer. Clinical Lung Cancer. PMID 27637408 DOI: 10.1200/Jco.2014.32.15_Suppl.8069  0.308
2016 Incio J, Liu H, Suboj P, Chin SM, Chen IX, Pinter M, Ng MR, Nia HT, Grahovac J, Kao S, Babykutty S, Huang Y, Jung K, Rahbari NN, Han X, ... ... Jain RK, et al. Obesity-induced inflammation and desmoplasia promote pancreatic cancer progression and resistance to chemotherapy. Cancer Discovery. PMID 27246539 DOI: 10.1158/2159-8290.Cd-15-1177  0.763
2016 Kloepper J, Riedemann L, Amoozgar Z, Seano G, Susek K, Yu V, Dalvie N, Amelung RL, Datta M, Song JW, Askoxylakis V, Taylor JW, Lu-Emerson C, Batista A, Kirkpatrick ND, ... ... Jain RK, et al. Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival. Proceedings of the National Academy of Sciences of the United States of America. PMID 27044098 DOI: 10.1073/Pnas.1525360113  0.365
2016 Peterson TE, Kirkpatrick ND, Huang Y, Farrar CT, Marijt KA, Kloepper J, Datta M, Amoozgar Z, Seano G, Jung K, Kamoun WS, Vardam T, Snuderl M, Goveia J, Chatterjee S, ... ... Jain RK, et al. Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages. Proceedings of the National Academy of Sciences of the United States of America. PMID 27044097 DOI: 10.1073/Pnas.1525349113  0.348
2016 Incio J, Tam J, Rahbari NN, Suboj P, McManus DT, Chin SM, Vardam T, Batista A, Babykutty S, Jung K, Khachatryan A, Hato T, Ligibel JA, Krop I, Puchner SB, ... ... Jain RK, et al. PlGF/VEGFR-1 signaling promotes macrophage polarization and accelerated tumor progression in obesity. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 26861455 DOI: 10.1158/1078-0432.Ccr-15-1839  0.342
2016 Fukumura D, Incio J, Shankaraiah R, Jain RK. Obesity and cancer: an angiogenic and inflammatory link. Microcirculation (New York, N.Y. : 1994). PMID 26808917 DOI: 10.1111/Micc.12270  0.324
2016 Whitley MJ, Cardona DM, Lazarides AL, Spasojevic I, Ferrer JM, Cahill J, Lee CL, Snuderl M, Blazer DG, Hwang ES, Greenup RA, Mosca PJ, Mito JK, Cuneo KC, Larrier NA, ... ... Jain RK, et al. A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer. Science Translational Medicine. 8: 320ra4. PMID 26738797 DOI: 10.1126/Scitranslmed.Aad0293  0.568
2016 Askoxylakis V, Ferraro GB, Kodack DP, Badeaux M, Shankaraiah RC, Seano G, Kloepper J, Vardam T, Martin JD, Naxerova K, Bezwada D, Qi X, Selig MK, Brachtel E, Duda DG, ... ... Jain RK, et al. Preclinical Efficacy of Ado-trastuzumab Emtansine in the Brain Microenvironment. Journal of the National Cancer Institute. 108. PMID 26547932 DOI: 10.1093/Jnci/Djv313  0.658
2016 Gerstner ER, Jain RK, Batchelor TT. Value of correlative biomarkers in understanding tumor biology Translational Cancer Research. 5: 211-212. DOI: 10.21037/7193  0.361
2016 Ng MR, Jain RK. Hypoxia-induced DNA hypermethylation: another reason to normalize tumor vessels Translational Cancer Research. 5. DOI: 10.21037/11295  0.355
2016 Ferraro GB, Askoxylakis V, Kodack DP, Badeaux M, Fukumura D, Engelman JA, Jain RK. Abstract A48: Ado-trastuzumab emtansine (T-DM1) controls tumor progression of established HER2-positive breast cancer brain metastases in mice Cancer Research. 76. DOI: 10.1158/1538-7445.Tummet15-A48  0.372
2016 Askoxylakis V, Ferraro G, Kodack D, Badeaux M, Jain R. Abstract P6-17-02: Ado-trastuzumab emtansine (T-DM1) is effective against established HER2-positive breast cancer brain metastases in mice Cancer Research. 76. DOI: 10.1158/1538-7445.Sabcs15-P6-17-02  0.337
2016 Yan S, Chatterjee S, Vardam T, Kitahara S, Hato T, Roberge S, Askoxylakis V, Duquette M, Fukumura D, Xu L, Jain R. Abstract A12: Microenvironmental Interleukin-6 induced activation of STAT3 signaling in medulloblastoma: Implications for molecular pathology and therapy Cancer Research. 76. DOI: 10.1158/1538-7445.Pedca15-A12  0.312
2016 Grahovac J, Han S, Liu H, Jain R, Boucher Y. Abstract B41: The angiotensin receptor blocker telmisartan inhibits the growth of pancreatic ductal adenocarcinoma and improves survival Cancer Research. 76. DOI: 10.1158/1538-7445.Panca16-B41  0.335
2016 Kloepper J, Riedemann L, Amoozgar Z, Seano G, Susek KH, Yu V, Dalvie N, Amelung RL, Datta M, Song JW, Askoxylakis V, Taylor JW, Lu-Emerson C, Batista A, Kirkpatrick ND, ... ... Jain RK, et al. Abstract LB-347: Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival Cancer Research. 76. DOI: 10.1158/1538-7445.Am2016-Lb-347  0.386
2016 Incio J, Liu H, Suboj P, Min S, Chen I, Ng M, Nia H, Grahovac J, Kao S, Babykutty S, Huang Y, Jung K, Rahbari N, Han X, Chauhan V, ... ... Jain R, et al. Abstract 898: Obesity-induced inflammation and desmoplasia promote pancreatic cancer progression and resistance to chemotherapy Cancer Research. 76: 898-898. DOI: 10.1158/1538-7445.Am2016-898  0.772
2016 Jung K, Heishi T, Yun A, Padera TP, Jain RK, Fukumura D. Abstract 4195: Targeting the immune microenvironment to improve colorectal cancer anti-angiogenic therapy Cancer Research. 76: 4195-4195. DOI: 10.1158/1538-7445.Am2016-4195  0.365
2016 Emblem KE, Gerstner ER, Sorensen G, Rosen BR, Wen PY, Batchelor TT, Jain RK. Abstract 3975: Matrix-depleting anti-hypertensives decompress tumor blood vessels and improve perfusion in patients with glioblastomas receiving anti-angiogenic therapy Cancer Research. 76: 3975-3975. DOI: 10.1158/1538-7445.Am2016-3975  0.397
2016 Kashany ZH, Ahn S, Nia HT, Tshikudi DM, Grodzinsky A, Jain RK, Nadkarni SK. Laser speckle micro rheology for micro-mechanical mapping of bio-materials(Conference Presentation) Proceedings of Spie. 9707: 970702. DOI: 10.1117/12.2213761  0.701
2016 Peterson T, Kirkpatrick N, Huang Y, Farrar C, Marjit K, Kloepper J, Datta M, Amoozgar Z, Seano G, Jung K, Kamoun W, Vardam T, Snuderl M, Goveia J, Chatterjee S, ... ... Jain R, et al. Tmic-07. Dual Inhibition Of Ang-2 And Vegf Receptors Normalizes Tumor Vasculature And Prolongs Survival In Glioblastoma By Altering Macrophages Neuro-Oncology. 18. DOI: 10.1093/Neuonc/Now212.847  0.331
2016 Riedemann L, Kloepper J, Amoozgar Z, Seano G, Susek K, Yu V, Dalvie N, Amelung R, Datta M, Song JW, Askoxylakis V, Taylor J, Lu-Emerson C, Batista A, Kirkpatrick N, ... ... Jain R, et al. IMST-40. REPROGRAMMING OF THE TUMOR IMMUNE MICROENVIRONMENT BY AN ANG-2/VEGF BISPECIFIC ANTIBODY DELAYS TUMOR GROWTH AND PROLONGS SURVIVAL IN PRECLINICAL GBM MODELS Neuro-Oncology. 18: vi95-vi95. DOI: 10.1093/Neuonc/Now212.396  0.372
2015 Incio J, Suboj P, Chin SM, Vardam-Kaur T, Liu H, Hato T, Babykutty S, Chen I, Deshpande V, Jain RK, Fukumura D. Metformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associated Macrophages. Plos One. 10: e0141392. PMID 26641266 DOI: 10.1371/Journal.Pone.0141392  0.359
2015 Tolaney SM, Boucher Y, Duda DG, Martin JD, Seano G, Ancukiewicz M, Barry WT, Goel S, Lahdenrata J, Isakoff SJ, Yeh ED, Jain SR, Golshan M, Brock J, Snuderl M, ... ... Jain RK, et al. Role of vascular density and normalization in response to neoadjuvant bevacizumab and chemotherapy in breast cancer patients. Proceedings of the National Academy of Sciences of the United States of America. 112: 14325-14330. PMID 26578779 DOI: 10.1073/Pnas.1518808112  0.336
2015 Gao X, Zhao Y, Stemmer-Rachamimov AO, Liu H, Huang P, Chin S, Selig MK, Plotkin SR, Jain RK, Xu L. Anti-VEGF treatment improves neurological function and augments radiation response in NF2 schwannoma model. Proceedings of the National Academy of Sciences of the United States of America. PMID 26554010 DOI: 10.1073/Pnas.1512570112  0.316
2015 Stylianopoulos T, Jain RK. Design considerations for nanotherapeutics in oncology. Nanomedicine : Nanotechnology, Biology, and Medicine. PMID 26282377 DOI: 10.1016/J.Nano.2015.07.015  0.337
2015 Batista A, Riedemann L, Vardam T, Jain RK. Targeting the Tumor Microenvironment to Enhance Pediatric Brain Cancer Treatment. Cancer Journal (Sudbury, Mass.). 21: 307-13. PMID 26222083 DOI: 10.1097/Ppo.0000000000000125  0.367
2015 Jain RK, Fukumura D, Duda DG. From the Guest Editors: Role of Tumor Microenvironment in Tumor Progression and Treatment Response: A 30 Years' Journey. Cancer Journal (Sudbury, Mass.). 21: 235-6. PMID 26222072 DOI: 10.1097/Ppo.0000000000000136  0.348
2015 Duda DG, Heist RS, Sahani DV, Stylianopoulos T, Engelman JA, Jain RK. Reply to Ciccolini et al.: Using mathematical modeling to predict response to antiangiogenic therapy in cancer patients. Proceedings of the National Academy of Sciences of the United States of America. 112: E3454. PMID 26080434 DOI: 10.1073/Pnas.1507225112  0.317
2015 Jain RK, Fukumura D, Duda DG. Lessons From 30 Years of Teaching About the Microenvironment of Tumors. Cancer Journal (Sudbury, Mass.). 21: 137. PMID 26049690 DOI: 10.1097/Ppo.0000000000000119  0.387
2015 Gerstner ER, Ye X, Duda DG, Levine MA, Mikkelsen T, Kaley TJ, Olson JJ, Nabors BL, Ahluwalia MS, Wen PY, Jain RK, Batchelor TT, Grossman S. A phase I study of cediranib in combination with cilengitide in patients with recurrent glioblastoma. Neuro-Oncology. PMID 26008604 DOI: 10.1093/Neuonc/Nov085  0.322
2015 Lu-Emerson C, Duda DG, Emblem KE, Taylor JW, Gerstner ER, Loeffler JS, Batchelor TT, Jain RK. Lessons from anti-vascular endothelial growth factor and anti-vascular endothelial growth factor receptor trials in patients with glioblastoma. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 33: 1197-213. PMID 25713439 DOI: 10.1200/Jco.2014.55.9575  0.355
2015 Ager EI, Kozin SV, Kirkpatrick ND, Seano G, Kodack DP, Askoxylakis V, Huang Y, Goel S, Snuderl M, Muzikansky A, Finkelstein DM, Dransfield DT, Devy L, Boucher Y, Fukumura D, ... Jain RK, et al. Blockade of MMP14 activity in murine breast carcinomas: implications for macrophages, vessels, and radiotherapy. Journal of the National Cancer Institute. 107. PMID 25710962 DOI: 10.1093/Jnci/Djv017  0.303
2015 Datta M, Via LE, Kamoun WS, Liu C, Chen W, Seano G, Weiner DM, Schimel D, England K, Martin JD, Gao X, Xu L, Barry CE, Jain RK. Anti-vascular endothelial growth factor treatment normalizes tuberculosis granuloma vasculature and improves small molecule delivery. Proceedings of the National Academy of Sciences of the United States of America. 112: 1827-32. PMID 25624495 DOI: 10.1073/Pnas.1424563112  0.33
2015 Heist RS, Duda DG, Sahani DV, Ancukiewicz M, Fidias P, Sequist LV, Temel JS, Shaw AT, Pennell NA, Neal JW, Gandhi L, Lynch TJ, Engelman JA, Jain RK. Improved tumor vascularization after anti-VEGF therapy with carboplatin and nab-paclitaxel associates with survival in lung cancer. Proceedings of the National Academy of Sciences of the United States of America. 112: 1547-52. PMID 25605928 DOI: 10.1073/Pnas.1424024112  0.348
2015 Naxerova K, Jain RK. Using tumour phylogenetics to identify the roots of metastasis in humans. Nature Reviews. Clinical Oncology. 12: 258-72. PMID 25601447 DOI: 10.1038/Nrclinonc.2014.238  0.66
2015 Chen Y, Ramjiawan RR, Reiberger T, Ng MR, Hato T, Huang Y, Ochiai H, Kitahara S, Unan EC, Reddy TP, Fan C, Huang P, Bardeesy N, Zhu AX, Jain RK, et al. CXCR4 inhibition in tumor microenvironment facilitates anti-programmed death receptor-1 immunotherapy in sorafenib-treated hepatocellular carcinoma in mice. Hepatology (Baltimore, Md.). 61: 1591-602. PMID 25529917 DOI: 10.1002/Hep.27665  0.328
2015 Chen Y, Reiberger T, Ramjiawan R, Ng MR, Hato T, Unan EC, Reddy TP, Ochiai H, Huang P, Zhu AX, Jain RK, Duda DG. Abstract B79: CXCR4 inhibition facilitates anti-PD-1 immunotherapy by reprogramming the tumor microenvironment during sorafenib treatment in hepatocellular carcinoma Cancer Immunology Research. 3. DOI: 10.1158/2326-6074.Tumimm14-B79  0.328
2015 Jain RK. Abstract IA03: Antiangiogenesis strategies revisited: From starving tumors to alleviating hypoxia Molecular Cancer Therapeutics. 14. DOI: 10.1158/1538-8514.Tumang15-Ia03  0.407
2015 Datta M, Via LE, Kamoun WS, Liu C, Chen W, Seano G, Weiner DM, Schimel D, England K, Martin JD, Gao X, Xu L, Barry CE, Jain RK. Abstract B19: Anti-VEGF treatment normalizes tuberculosis granuloma vasculature and improves small molecule delivery Molecular Cancer Therapeutics. 14. DOI: 10.1158/1538-8514.Tumang15-B19  0.322
2015 Seano G, Chiaverina G, Gagliardi PA, Blasio Ld, Puliafito A, Bouvard C, Sessa R, Tarone G, Sorokin L, Helley D, Jain RK, Serini G, Bussolino F, Primo L. Abstract A13: Endothelial podosome rosettes regulate vascular branching in tumor angiogenesis Molecular Cancer Therapeutics. 14. DOI: 10.1158/1538-8514.Tumang15-A13  0.317
2015 Incio J, McManus D, Suboj P, Rahbari N, Chin SM, Babycutty S, Vardan-Kaur T, Huang Y, Jung K, Duda D, Soares R, Fukumura D, Jain RK. Abstract LB-203: Obesity promotes resistance to anti-VEGF therapy in breast cancer via pro-inflammatory and angiogenic pathways Cancer Research. 75. DOI: 10.1158/1538-7445.Am2015-Lb-203  0.314
2015 Jain RK, Sharma P. Part 2: Targeting Cancer Pathways: The Tumor Microenvironment Science. 347: 680.3-680. DOI: 10.1126/Science.347.6222.680-C  0.402
2015 Griveau A, Shelton S, Tien A, Seano G, Yuen T, Sabo J, Lau J, Jahangiri A, Huillard E, Phillips J, Persson A, Oldham M, Weiss W, Aghi M, Stiles C, ... ... Jain R, et al. ANGI-04Olig2 REGULATES Wnt7b EXPRESSION AND VASCULATURE CHARACTERISTICS IN GLIOMA Neuro-Oncology. 17: v41.4-v41. DOI: 10.1093/Neuonc/Nov207.04  0.347
2014 Jain RK. Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia. Cancer Cell. 26: 605-22. PMID 25517747 DOI: 10.1016/J.Ccell.2014.10.006  0.398
2014 Duda DG, Ancukiewicz M, Isakoff SJ, Krop IE, Jain RK. Seeds and soil: unraveling the role of local tumor stroma in distant metastasis. Journal of the National Cancer Institute. 106. PMID 25082335 DOI: 10.1093/Jnci/Dju187  0.412
2014 Chauhan VP, Boucher Y, Ferrone CR, Roberge S, Martin JD, Stylianopoulos T, Bardeesy N, DePinho RA, Padera TP, Munn LL, Jain RK. Compression of pancreatic tumor blood vessels by hyaluronan is caused by solid stress and not interstitial fluid pressure. Cancer Cell. 26: 14-5. PMID 25026209 DOI: 10.1016/J.Ccr.2014.06.003  0.642
2014 Jain RK, Martin JD, Stylianopoulos T. The role of mechanical forces in tumor growth and therapy. Annual Review of Biomedical Engineering. 16: 321-46. PMID 25014786 DOI: 10.1146/Annurev-Bioeng-071813-105259  0.405
2014 Naxerova K, Brachtel E, Salk JJ, Seese AM, Power K, Abbasi B, Snuderl M, Chiang S, Kasif S, Jain RK. Hypermutable DNA chronicles the evolution of human colon cancer. Proceedings of the National Academy of Sciences of the United States of America. 111: E1889-98. PMID 24753616 DOI: 10.1073/Pnas.1400179111  0.666
2014 Jain RK. An indirect way to tame cancer. Scientific American. 310: 46-53. PMID 24640331 DOI: 10.1038/Scientificamerican0214-46  0.309
2014 Pinho MC, Polaskova P, Kalpathy-Cramer J, Jennings D, Emblem KE, Jain RK, Rosen BR, Wen PY, Sorensen AG, Batchelor TT, Gerstner ER. Low incidence of pseudoprogression by imaging in newly diagnosed glioblastoma patients treated with cediranib in combination with chemoradiation. The Oncologist. 19: 75-81. PMID 24309981 DOI: 10.1634/Theoncologist.2013-0101  0.301
2014 Chen Y, Huang Y, Reiberger T, Duyverman AM, Huang P, Samuel R, Hiddingh L, Roberge S, Koppel C, Lauwers GY, Zhu AX, Jain RK, Duda DG. Differential effects of sorafenib on liver versus tumor fibrosis mediated by stromal-derived factor 1 alpha/C-X-C receptor type 4 axis and myeloid differentiation antigen-positive myeloid cell infiltration in mice. Hepatology (Baltimore, Md.). 59: 1435-47. PMID 24242874 DOI: 10.1002/Hep.26790  0.337
2014 Faber AC, Coffee EM, Costa C, Dastur A, Ebi H, Hata AN, Yeo AT, Edelman EJ, Song Y, Tam AT, Boisvert JL, Milano RJ, Roper J, Kodack DP, Jain RK, et al. mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1. Cancer Discovery. 4: 42-52. PMID 24163374 DOI: 10.1158/2159-8290.Cd-13-0315  0.3
2014 Lemon CM, Curtin PN, Somers RC, Greytak AB, Lanning RM, Jain RK, Bawendi MG, Nocera DG. Metabolic tumor profiling with pH, oxygen, and glucose chemosensors on a quantum dot scaffold. Inorganic Chemistry. 53: 1900-15. PMID 24143874 DOI: 10.1021/Ic401587R  0.308
2014 Snurdel M, Batista A, Kirkpatrick N, Almodovar C, Riedemann L, Peterson T, Ferrara N, Klagsbrun M, Duda DG, Fukumura D, Xu L, Carmeliet P, Jain R. Abstract IA17: Targeting placental growth factor/ neuropilin-1 pathway inhibits growth and spread of medulloblastoma Cancer Research. 74. DOI: 10.1158/1538-7445.Pedcan-Ia17  0.38
2014 Batchelor TT, Gerstner ER, Emblem KE, Duda DG, Kalpathy-Cramer J, Snuderl M, Ancukiewicz M, Polaskova P, Pinho MC, Jennings D, Plotkin SR, Chi AS, Eichler AF, Dietrich J, Hochberg FH, ... ... Jain RK, et al. INCREASED PERFUSION DUE TO VASCULAR NORMALIZATION IMPROVES OXYGENATION AND SURVIVAL IN GLIOBLASTOMA PATIENTS TREATED WITH CEDIRANIB WITH OR WITHOUT CHEMORADIATION Neuro-Oncology. 16: iii12-iii12. DOI: 10.1093/Neuonc/Nou206.42  0.382
2014 Reiberger T, Chen B, Huang P, Lauwers G, Zhu A, Jain R. HCC resistance to sorafenib can be caused by hypoxia-induced SDF1a/CXCR4 upregulation leading to tumor desmoplasia and GR1+ cell infiltration Zeitschrift Fur Gastroenterologie. 52: 74. DOI: 10.1055/S-0034-1376058  0.303
2013 Batchelor TT, Gerstner ER, Emblem KE, Duda DG, Kalpathy-Cramer J, Snuderl M, Ancukiewicz M, Polaskova P, Pinho MC, Jennings D, Plotkin SR, Chi AS, Eichler AF, Dietrich J, Hochberg FH, ... ... Jain RK, et al. Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation. Proceedings of the National Academy of Sciences of the United States of America. 110: 19059-64. PMID 24190997 DOI: 10.1073/Pnas.1318022110  0.387
2013 Stylianopoulos T, Jain RK. Combining two strategies to improve perfusion and drug delivery in solid tumors. Proceedings of the National Academy of Sciences of the United States of America. 110: 18632-7. PMID 24167277 DOI: 10.1073/Pnas.1318415110  0.403
2013 Chauhan VP, Jain RK. Strategies for advancing cancer nanomedicine. Nature Materials. 12: 958-62. PMID 24150413 DOI: 10.1038/Nmat3792  0.63
2013 Chauhan VP, Martin JD, Liu H, Lacorre DA, Jain SR, Kozin SV, Stylianopoulos T, Mousa AS, Han X, Adstamongkonkul P, Popovi? Z, Huang P, Bawendi MG, Boucher Y, Jain RK. Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels. Nature Communications. 4: 2516. PMID 24084631 DOI: 10.1038/Ncomms3516  0.653
2013 Goel S, Gupta N, Walcott BP, Snuderl M, Kesler CT, Kirkpatrick ND, Heishi T, Huang Y, Martin JD, Ager E, Samuel R, Wang S, Yazbek J, Vakoc BJ, Peterson RT, ... ... Jain RK, et al. Effects of vascular-endothelial protein tyrosine phosphatase inhibition on breast cancer vasculature and metastatic progression. Journal of the National Cancer Institute. 105: 1188-201. PMID 23899555 DOI: 10.1093/Jnci/Djt164  0.415
2013 Lu-Emerson C, Snuderl M, Kirkpatrick ND, Goveia J, Davidson C, Huang Y, Riedemann L, Taylor J, Ivy P, Duda DG, Ancukiewicz M, Plotkin SR, Chi AS, Gerstner ER, Eichler AF, ... ... Jain RK, et al. Increase in tumor-associated macrophages after antiangiogenic therapy is associated with poor survival among patients with recurrent glioblastoma. Neuro-Oncology. 15: 1079-87. PMID 23828240 DOI: 10.1093/Neuonc/Not082  0.364
2013 Jain RK, Munn LL, Fukumura D. Measuring interstitial diffusion, convection, and binding parameters in mouse tumors. Cold Spring Harbor Protocols. 2013: 678-80. PMID 23818670 DOI: 10.1101/Pdb.Prot075721  0.313
2013 Jain RK, Munn LL, Fukumura D. Measuring leukocyte-endothelial interactions in mice. Cold Spring Harbor Protocols. 2013: 561-3. PMID 23734020 DOI: 10.1101/Pdb.Prot075085  0.322
2013 Duda DG, Munn LL, Jain RK. Can we identify predictive biomarkers for antiangiogenic therapy of cancer using mathematical modeling? Journal of the National Cancer Institute. 105: 762-5. PMID 23670727 DOI: 10.1093/Jnci/Djt114  0.378
2013 Jain RK. Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 31: 2205-18. PMID 23669226 DOI: 10.1200/Jco.2012.46.3653  0.424
2013 Jain RK, Munn LL, Fukumura D. Measuring vascular permeability in mice. Cold Spring Harbor Protocols. 2013: 444-6. PMID 23637370 DOI: 10.1101/Pdb.Prot074344  0.309
2013 Stylianopoulos T, Martin JD, Snuderl M, Mpekris F, Jain SR, Jain RK. Coevolution of solid stress and interstitial fluid pressure in tumors during progression: implications for vascular collapse. Cancer Research. 73: 3833-41. PMID 23633490 DOI: 10.1158/0008-5472.Can-12-4521  0.373
2013 Jain RK, Munn LL, Fukumura D. Measuring angiogenesis and hemodynamics in mice. Cold Spring Harbor Protocols. 2013: 354-8. PMID 23547161 DOI: 10.1101/Pdb.Prot073916  0.34
2013 Snuderl M, Batista A, Kirkpatrick ND, Ruiz de Almodovar C, Riedemann L, Walsh EC, Anolik R, Huang Y, Martin JD, Kamoun W, Knevels E, Schmidt T, Farrar CT, Vakoc BJ, Mohan N, ... ... Jain RK, et al. Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma. Cell. 152: 1065-76. PMID 23452854 DOI: 10.1016/J.Cell.2013.01.036  0.382
2013 Huang Y, Goel S, Duda DG, Fukumura D, Jain RK. Vascular normalization as an emerging strategy to enhance cancer immunotherapy. Cancer Research. 73: 2943-8. PMID 23440426 DOI: 10.1158/0008-5472.Can-12-4354  0.389
2013 Prabhakar U, Maeda H, Jain RK, Sevick-Muraca EM, Zamboni W, Farokhzad OC, Barry ST, Gabizon A, Grodzinski P, Blakey DC. Challenges and key considerations of the enhanced permeability and retention effect for nanomedicine drug delivery in oncology. Cancer Research. 73: 2412-7. PMID 23423979 DOI: 10.1158/0008-5472.Can-12-4561  0.358
2013 Chen O, Zhao J, Chauhan VP, Cui J, Wong C, Harris DK, Wei H, Han HS, Fukumura D, Jain RK, Bawendi MG. Compact high-quality CdSe-CdS core-shell nanocrystals with narrow emission linewidths and suppressed blinking. Nature Materials. 12: 445-51. PMID 23377294 DOI: 10.1038/Nmat3539  0.579
2013 Stylianopoulos T, Soteriou K, Fukumura D, Jain RK. Cationic nanoparticles have superior transvascular flux into solid tumors: insights from a mathematical model. Annals of Biomedical Engineering. 41: 68-77. PMID 22855118 DOI: 10.1007/S10439-012-0630-4  0.303
2013 Huang Y, Yuan J, Righi E, Duda DG, Fukumura D, Poznansky MC, Jain RK. Vascular normalization: a strategy to recondition the tumor immune microenvironment Journal For Immunotherapy of Cancer. 1. DOI: 10.1186/2051-1426-1-S1-P155  0.421
2013 Huang Y, Yuan J, Righi E, Duda DG, Fukumura D, Poznansky MC, Jain RK. Abstract A67: Reconditioning the tumor immune microenvironment for a breast cancer vaccine therapy. Cancer Research. 73. DOI: 10.1158/1538-7445.Tumimm2012-A67  0.388
2013 Duda DG, Tolaney SM, Ancukiewicz M, Winer EP, Krop IE, Jain RK. Abstract LB-81: A study of circulating biomarkers of angiogenesis and inflammation in ER+ breast cancer (BC) versus triple-negative breast cancer (TNBC) patients enrolled in a phase II study of preoperative treatment with 1 cycle of Bevacizumab followed by standard chemo Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Lb-81  0.329
2013 Stylianopoulos T, Martin JD, Jain S, Snuderl M, Chauhan VP, Munn LL, Boucher Y, Jain RK. Abstract LB-348: Evolution of physical forces in the tumor microenvironment and implications for therapeutic resistance. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Lb-348  0.681
2013 Huang Y, Yuan J, Righi E, Duda DG, Fukumura D, Poznanasky MC, Jain RK. Abstract LB-344: Vascular normalization as an emerging strategy to enhance cancer immunotherapy. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Lb-344  0.387
2013 Lu-Emerson C, Snuderl M, Kirkpatrick ND, Goveia J, Taylor J, Davidson C, Huang Y, Riedemann L, Ivy SP, Duda GD, Ancukiewicz M, Plotkin SR, Chi A, Gerstner ER, Eichler AF, ... ... Jain RK, et al. Abstract LB-339: Increase in tumor-associated macrophages (TAMs) after antiangiogenic therapy is associated with poor survival in recurrent glioblastoma (GBM) patients. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Lb-339  0.363
2013 Emblem KE, Mouridsen K, Bjornerud A, Farrar CT, Jennings D, Borra RJH, Wen PY, Ivy P, Batchelor TT, Rosen BR, Jain RK, Sorensen AG. Abstract LB-297: Vessel architectural imaging identifies cancer patient responders to anti-angiogenic therapy. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Lb-297  0.332
2013 Blauvelt D, Mohan N, Bouma B, Jain R, Padera T, Vakoc B. Abstract 713: Three-dimensionalin vivoblood flow mapping in tumors using optical frequency domain imaging. Cancer Research. 73: 713-713. DOI: 10.1158/1538-7445.Am2013-713  0.345
2013 Vakoc BJ, Fukumura D, Padera TP, Jain RK, Bouma BE. Abstract 3925: Optical coherence tomography imaging in cancer research. Cancer Research. 73: 3925-3925. DOI: 10.1158/1538-7445.Am2013-3925  0.301
2013 Coffee EM, Faber AC, Costa C, Dastur A, Ebi H, Hata AN, Yeo AT, J E, Song Y, Tam AT, Boisvert JL, Milano RJ, Roper J, Kodack DP, Jain RK, et al. Abstract C263: mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-C263  0.3
2013 Goel S, Gupta N, Walcott BP, Snuderl M, Kesler CT, Vakoc BJ, Peterson RT, Padera TP, Duda DG, Fukumura D, Jain RK. Abstract C1: Functional normalization of the breast cancer vasculature through activation of Tie2 using a vascular-endothelial protein tyrosine phosphatase inhibitor. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-C1  0.411
2013 Jain RK, Chauhan VP, Duda DG. Vascular and Interstitial Biology of Tumors Abeloff's Clinical Oncology: Fifth Edition. 108-126.e6. DOI: 10.1016/B978-1-4557-2865-7.00008-4  0.623
2012 Jain RK. Delivery of molecular and cellular medicine to solid tumors. Advanced Drug Delivery Reviews. 64: 353-365. PMID 24511174 DOI: 10.1016/J.Addr.2012.09.011  0.413
2012 Jain RK, Munn LL, Fukumura D. Liver tumor preparation in mice. Cold Spring Harbor Protocols. 2012. PMID 23209146 DOI: 10.1101/Pdb.Prot072371  0.366
2012 Jain RK, Munn LL, Fukumura D. Pancreatic tumor preparation in mice. Cold Spring Harbor Protocols. 2012. PMID 23209145 DOI: 10.1101/Pdb.Prot072363  0.352
2012 Jain RK, Munn LL, Fukumura D. Lymphangiography of the mouse tail. Cold Spring Harbor Protocols. 2012: 1177-8. PMID 23118364 DOI: 10.1101/Pdb.Prot072108  0.379
2012 Kodack DP, Chung E, Yamashita H, Incio J, Duyverman AM, Song Y, Farrar CT, Huang Y, Ager E, Kamoun W, Goel S, Snuderl M, Lussiez A, Hiddingh L, Mahmood S, ... ... Jain RK, et al. Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases. Proceedings of the National Academy of Sciences of the United States of America. 109: E3119-27. PMID 23071298 DOI: 10.1073/Pnas.1216078109  0.345
2012 Huang Y, Yuan J, Righi E, Kamoun WS, Ancukiewicz M, Nezivar J, Santosuosso M, Martin JD, Martin MR, Vianello F, Leblanc P, Munn LL, Huang P, Duda DG, Fukumura D, ... Jain RK, et al. Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy. Proceedings of the National Academy of Sciences of the United States of America. 109: 17561-6. PMID 23045683 DOI: 10.1073/Pnas.1215397109  0.39
2012 Jain RK, Munn LL, Fukumura D. Mammary fat pad tumor preparation in mice. Cold Spring Harbor Protocols. 2012: 1115-6. PMID 23028076 DOI: 10.1101/Pdb.Prot071514  0.397
2012 Liu J, Liao S, Diop-Frimpong B, Chen W, Goel S, Naxerova K, Ancukiewicz M, Boucher Y, Jain RK, Xu L. TGF-β blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma. Proceedings of the National Academy of Sciences of the United States of America. 109: 16618-23. PMID 22996328 DOI: 10.1073/Pnas.1117610109  0.771
2012 Stylianopoulos T, Martin JD, Chauhan VP, Jain SR, Diop-Frimpong B, Bardeesy N, Smith BL, Ferrone CR, Hornicek FJ, Boucher Y, Munn LL, Jain RK. Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors. Proceedings of the National Academy of Sciences of the United States of America. 109: 15101-8. PMID 22932871 DOI: 10.1073/Pnas.1213353109  0.786
2012 Jain RK, Munn LL, Fukumura D. Rabbit ear chambers. Cold Spring Harbor Protocols. 2012: 813-14. PMID 22753607 DOI: 10.1101/Pdb.Prot070045  0.305
2012 Kozin SV, Duda DG, Munn LL, Jain RK. Neovascularization after irradiation: what is the source of newly formed vessels in recurring tumors? Journal of the National Cancer Institute. 104: 899-905. PMID 22572994 DOI: 10.1093/Jnci/Djs239  0.38
2012 Goel S, Fukumura D, Jain RK. Normalization of the tumor vasculature through oncogenic inhibition: an emerging paradigm in tumor biology. Proceedings of the National Academy of Sciences of the United States of America. 109: E1214. PMID 22550180 DOI: 10.1073/Pnas.1203794109  0.372
2012 Chauhan VP, Stylianopoulos T, Martin JD, Popovi? Z, Chen O, Kamoun WS, Bawendi MG, Fukumura D, Jain RK. Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner. Nature Nanotechnology. 7: 383-8. PMID 22484912 DOI: 10.1038/Nnano.2012.45  0.626
2012 Stylianopoulos T, Wong C, Bawendi MG, Jain RK, Fukumura D. Multistage nanoparticles for improved delivery into tumor tissue. Methods in Enzymology. 508: 109-30. PMID 22449923 DOI: 10.1016/B978-0-12-391860-4.00006-9  0.392
2012 Duyverman AM, Kohno M, Duda DG, Jain RK, Fukumura D. A transient parabiosis skin transplantation model in mice. Nature Protocols. 7: 763-70. PMID 22441295 DOI: 10.1038/Nprot.2012.032  0.361
2012 Duyverman AM, Steller EJ, Fukumura D, Jain RK, Duda DG. Studying primary tumor-associated fibroblast involvement in cancer metastasis in mice. Nature Protocols. 7: 756-62. PMID 22441294 DOI: 10.1038/Nprot.2012.031  0.372
2012 Duyverman AM, Kohno M, Roberge S, Fukumura D, Duda DG, Jain RK. An isolated tumor perfusion model in mice. Nature Protocols. 7: 749-55. PMID 22441293 DOI: 10.1038/Nprot.2012.030  0.397
2012 Wong HK, Shimizu A, Kirkpatrick ND, Garkavtsev I, Chan AW, di Tomaso E, Klagsbrun M, Jain RK. Merlin/NF2 regulates angiogenesis in schwannomas through a Rac1/semaphorin 3F-dependent mechanism. Neoplasia (New York, N.Y.). 14: 84-94. PMID 22431917 DOI: 10.1593/Neo.111600  0.384
2012 Goel S, Wong AH, Jain RK. Vascular normalization as a therapeutic strategy for malignant and nonmalignant disease. Cold Spring Harbor Perspectives in Medicine. 2: a006486. PMID 22393532 DOI: 10.1101/Cshperspect.A006486  0.368
2012 Raut CP, Boucher Y, Duda DG, Morgan JA, Quek R, Ancukiewicz M, Lahdenranta J, Eder JP, Demetri GD, Jain RK. Effects of sorafenib on intra-tumoral interstitial fluid pressure and circulating biomarkers in patients with refractory sarcomas (NCI protocol 6948). Plos One. 7: e26331. PMID 22347360 DOI: 10.1371/Journal.Pone.0026331  0.373
2012 Tse JM, Cheng G, Tyrrell JA, Wilcox-Adelman SA, Boucher Y, Jain RK, Munn LL. Mechanical compression drives cancer cells toward invasive phenotype. Proceedings of the National Academy of Sciences of the United States of America. 109: 911-6. PMID 22203958 DOI: 10.1073/Pnas.1118910109  0.333
2012 Sorensen AG, Emblem KE, Polaskova P, Jennings D, Kim H, Ancukiewicz M, Wang M, Wen PY, Ivy P, Batchelor TT, Jain RK. Increased survival of glioblastoma patients who respond to antiangiogenic therapy with elevated blood perfusion. Cancer Research. 72: 402-7. PMID 22127927 DOI: 10.1158/0008-5472.Can-11-2464  0.372
2012 Pinho MC, Polaskova P, Jennings D, Wen PY, Jain RK, Sorensen AG, Gerstner ER, Batchelor T. Impact of adjuvant anti-VEGF therapy on treatment-related pseudoprogression in patients with newly diagnosed glioblastoma receiving chemoradiation with or without anti-VEGF therapy. Journal of Clinical Oncology. 30: 2025-2025. DOI: 10.1200/Jco.2012.30.15_Suppl.2025  0.307
2012 Lu-Emerson C, Snuderl M, Davidson C, Kirkpatrick ND, Huang Y, Duda DG, Ancukiewicz M, Stemmer-Rachamimov A, Batchelor T, Jain RK. Effect of antiangiogenic therapy on tumor-associated macrophages in recurrent glioblastoma. Journal of Clinical Oncology. 30: 2010-2010. DOI: 10.1200/Jco.2012.30.15_Suppl.2010  0.33
2012 Gerstner ER, Emblem KE, Chi AS, Eichler AF, Hochberg F, Drappatz J, Quant EC, Norden AD, Pinho MC, Polaskova P, Jennings D, Ancukiewicz M, Ivy SP, Wen PY, Jain RK, et al. Effects of cediranib, a VEGF signaling inhibitor, in combination with chemoradiation on tumor blood flow and survival in newly diagnosed glioblastoma. Journal of Clinical Oncology. 30: 2009-2009. DOI: 10.1200/Jco.2012.30.15_Suppl.2009  0.309
2012 Kodack D, Chung E, Yamashita H, Incio J, Peters A, Song Y, Ager E, Huang Y, Farrar C, Lussiez A, Goel S, Snuderl M, Kamoun W, Hiddingh L, Tannous B, ... ... Jain R, et al. Abstract P3-12-03: Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases. Cancer Research. 72. DOI: 10.1158/0008-5472.Sabcs12-P3-12-03  0.359
2012 Stylianopoulos T, Martin JD, Chauhan VP, Munn LL, Jain RK. Residual stresses in solid tumors: Implications to tumor growth and drug delivery Asme 2012 Summer Bioengineering Conference, Sbc 2012. 207-208. DOI: 10.1115/SBC2012-80235  0.629
2011 Chauhan VP, Stylianopoulos T, Boucher Y, Jain RK. Delivery of molecular and nanoscale medicine to tumors: transport barriers and strategies. Annual Review of Chemical and Biomolecular Engineering. 2: 281-98. PMID 22432620 DOI: 10.1146/Annurev-Chembioeng-061010-114300  0.666
2011 Chauhan VP, Popovi? Z, Chen O, Cui J, Fukumura D, Bawendi MG, Jain RK. Fluorescent nanorods and nanospheres for real-time in vivo probing of nanoparticle shape-dependent tumor penetration. Angewandte Chemie (International Ed. in English). 50: 11417-20. PMID 22113800 DOI: 10.1002/Anie.201104449  0.657
2011 Goel S, Duda DG, Xu L, Munn LL, Boucher Y, Fukumura D, Jain RK. Normalization of the vasculature for treatment of cancer and other diseases. Physiological Reviews. 91: 1071-121. PMID 21742796 DOI: 10.1152/Physrev.00038.2010  0.432
2011 Garkavtsev I, Chauhan VP, Wong HK, Mukhopadhyay A, Glicksman MA, Peterson RT, Jain RK. Dehydro-alpha-lapachone, a plant product with antivascular activity. Proceedings of the National Academy of Sciences of the United States of America. 108: 11596-601. PMID 21709229 DOI: 10.1073/Pnas.1104225108  0.633
2011 Carmeliet P, Jain RK. Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases. Nature Reviews. Drug Discovery. 10: 417-27. PMID 21629292 DOI: 10.1038/Nrd3455  0.316
2011 Carmeliet P, Jain RK. Molecular mechanisms and clinical applications of angiogenesis Nature. 473: 298-307. PMID 21593862 DOI: 10.1038/Nature10144  0.328
2011 Perentes JY, Kirkpatrick ND, Nagano S, Smith EY, Shaver CM, Sgroi D, Garkavtsev I, Munn LL, Jain RK, Boucher Y. Cancer cell-associated MT1-MMP promotes blood vessel invasion and distant metastasis in triple-negative mammary tumors. Cancer Research. 71: 4527-38. PMID 21571860 DOI: 10.1158/0008-5472.Can-10-4376  0.328
2011 Kim H, Catana C, Ratai EM, Andronesi OC, Jennings DL, Batchelor TT, Jain RK, Sorensen AG. Serial magnetic resonance spectroscopy reveals a direct metabolic effect of cediranib in glioblastoma. Cancer Research. 71: 3745-52. PMID 21507932 DOI: 10.1158/0008-5472.Can-10-2991  0.323
2011 Eichler AF, Chung E, Kodack DP, Loeffler JS, Fukumura D, Jain RK. The biology of brain metastases-translation to new therapies. Nature Reviews. Clinical Oncology. 8: 344-56. PMID 21487419 DOI: 10.1038/Nrclinonc.2011.58  0.351
2011 Liu J, Liao S, Huang Y, Samuel R, Shi T, Naxerova K, Huang P, Kamoun W, Jain RK, Fukumura D, Xu L. PDGF-D improves drug delivery and efficacy via vascular normalization, but promotes lymphatic metastasis by activating CXCR4 in breast cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 3638-48. PMID 21459800 DOI: 10.1158/1078-0432.Ccr-10-2456  0.674
2011 Farrar CT, Kamoun WS, Ley CD, Kim YR, Catana C, Kwon SJ, Rosen BR, Jain RK, Sorensen AG. Sensitivity of MRI tumor biomarkers to VEGFR inhibitor therapy in an orthotopic mouse glioma model. Plos One. 6: e17228. PMID 21390238 DOI: 10.1371/Journal.Pone.0017228  0.401
2011 Zhu AX, Duda DG, Sahani DV, Jain RK. HCC and angiogenesis: possible targets and future directions. Nature Reviews. Clinical Oncology. 8: 292-301. PMID 21386818 DOI: 10.1038/Nrclinonc.2011.30  0.327
2011 Duda DG, Kozin SV, Kirkpatrick ND, Xu L, Fukumura D, Jain RK. CXCL12 (SDF1alpha)-CXCR4/CXCR7 pathway inhibition: an emerging sensitizer for anticancer therapies? Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 2074-80. PMID 21349998 DOI: 10.1158/1078-0432.Ccr-10-2636  0.372
2011 Hiratsuka S, Goel S, Kamoun WS, Maru Y, Fukumura D, Duda DG, Jain RK. Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation. Proceedings of the National Academy of Sciences of the United States of America. 108: 3725-30. PMID 21321210 DOI: 10.1073/Pnas.1100446108  0.319
2011 Diop-Frimpong B, Chauhan VP, Krane S, Boucher Y, Jain RK. Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors. Proceedings of the National Academy of Sciences of the United States of America. 108: 2909-14. PMID 21282607 DOI: 10.1073/Pnas.1018892108  0.79
2011 Liao S, Liu J, Lin P, Shi T, Jain RK, Xu L. TGF-beta blockade controls ascites by preventing abnormalization of lymphatic vessels in orthotopic human ovarian carcinoma models. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 1415-24. PMID 21278244 DOI: 10.1158/1078-0432.Ccr-10-2429  0.303
2011 Huang Y, Snuderl M, Jain RK. Polarization of tumor-associated macrophages: a novel strategy for vascular normalization and antitumor immunity. Cancer Cell. 19: 1-2. PMID 21251607 DOI: 10.1016/J.Ccr.2011.01.005  0.393
2011 Wong C, Stylianopoulos T, Cui J, Martin J, Chauhan VP, Jiang W, Popovic Z, Jain RK, Bawendi MG, Fukumura D. Multistage nanoparticle delivery system for deep penetration into tumor tissue. Proceedings of the National Academy of Sciences of the United States of America. 108: 2426-31. PMID 21245339 DOI: 10.1073/Pnas.1018382108  0.649
2011 Baish JW, Stylianopoulos T, Lanning RM, Kamoun WS, Fukumura D, Munn LL, Jain RK. Scaling rules for diffusive drug delivery in tumor and normal tissues. Proceedings of the National Academy of Sciences of the United States of America. 108: 1799-803. PMID 21224417 DOI: 10.1073/Pnas.1018154108  0.356
2011 di Tomaso E, Snuderl M, Kamoun WS, Duda DG, Auluck PK, Fazlollahi L, Andronesi OC, Frosch MP, Wen PY, Plotkin SR, Hedley-Whyte ET, Sorensen AG, Batchelor TT, Jain RK. Glioblastoma recurrence after cediranib therapy in patients: lack of "rebound" revascularization as mode of escape. Cancer Research. 71: 19-28. PMID 21199795 DOI: 10.1158/0008-5472.Can-10-2602  0.376
2011 Hiratsuka S, Duda DG, Huang Y, Goel S, Sugiyama T, Nagasawa T, Fukumura D, Jain RK. C-X-C receptor type 4 promotes metastasis by activating p38 mitogen-activated protein kinase in myeloid differentiation antigen (Gr-1)-positive cells. Proceedings of the National Academy of Sciences of the United States of America. 108: 302-7. PMID 21173223 DOI: 10.1073/Pnas.1016917108  0.355
2011 Gerstner ER, Eichler AF, Plotkin SR, Drappatz J, Doyle CL, Xu L, Duda DG, Wen PY, Jain RK, Batchelor TT. Phase I trial with biomarker studies of vatalanib (PTK787) in patients with newly diagnosed glioblastoma treated with enzyme inducing anti-epileptic drugs and standard radiation and temozolomide Journal of Neuro-Oncology. 103: 325-332. PMID 20821342 DOI: 10.1007/S11060-010-0390-7  0.314
2011 Jain RK. Abstract IA4: Normalizing the tumor microenvironment to enhance therapeutic outcome Cancer Research. 71. DOI: 10.1158/1538-7445.Fbcr11-Ia4  0.417
2011 Heishi T, Tsukada K, Huang Y, Kozin S, Jain RK, Fukumura D. Abstract LB-288: Restoration of peri-vascular nitric oxide gradient radio-sensitizes murine breast cancers via vascular normalization. Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-288  0.404
2011 Liu J, Liao S, Diop B, Chen W, Goel S, Huang Y, Boucher Y, Jain RK, Xu L. Abstract 715: TGF-beta blockade improves the distribution and efficacy of chemotherapeutic agents in breast carcinoma Cancer Research. 71: 715-715. DOI: 10.1158/1538-7445.Am2011-715  0.314
2011 Wong CR, Stylianopoulos T, Bhaumik J, Cui J, Martin J, Chauhan V, Popović Z, Chen O, Jain R, Fukumura D, Bawendi M. Abstract 548: Multistage nanoparticle delivery system for deep penetration into solid tumor Cancer Research. 71: 548-548. DOI: 10.1158/1538-7445.Am2011-548  0.669
2011 Liao S, Liu J, Jain RK, Xu L. Abstract 1579: TGF-β blockade controls ascites by preventing abnormalization of lymphatic vessels in orthotopic human ovarian carcinoma model Cancer Research. 71: 1579-1579. DOI: 10.1158/1538-7445.Am2011-1579  0.326
2010 Duda DG, Duyverman AM, Kohno M, Snuderl M, Steller EJ, Fukumura D, Jain RK. Malignant cells facilitate lung metastasis by bringing their own soil. Proceedings of the National Academy of Sciences of the United States of America. 107: 21677-82. PMID 21098274 DOI: 10.1073/Pnas.1016234107  0.371
2010 Stylianopoulos T, Diop-Frimpong B, Munn LL, Jain RK. Diffusion anisotropy in collagen gels and tumors: the effect of fiber network orientation. Biophysical Journal. 99: 3119-28. PMID 21081058 DOI: 10.1016/J.Bpj.2010.08.065  0.763
2010 Popovi? Z, Liu W, Chauhan VP, Lee J, Wong C, Greytak AB, Insin N, Nocera DG, Fukumura D, Jain RK, Bawendi MG. A nanoparticle size series for in vivo fluorescence imaging. Angewandte Chemie (International Ed. in English). 49: 8649-52. PMID 20886481 DOI: 10.1002/Anie.201003142  0.632
2010 Jain RK, Stylianopoulos T. Delivering nanomedicine to solid tumors. Nature Reviews. Clinical Oncology. 7: 653-64. PMID 20838415 DOI: 10.1038/Nrclinonc.2010.139  0.398
2010 Kozin SV, Kamoun WS, Huang Y, Dawson MR, Jain RK, Duda DG. Recruitment of myeloid but not endothelial precursor cells facilitates tumor regrowth after local irradiation. Cancer Research. 70: 5679-85. PMID 20631066 DOI: 10.1158/0008-5472.Can-09-4446  0.389
2010 Duda DG, Jain RK. Premetastatic lung "niche": is vascular endothelial growth factor receptor 1 activation required? Cancer Research. 70: 5670-3. PMID 20587530 DOI: 10.1158/0008-5472.Can-10-0119  0.366
2010 Kamoun WS, Chae SS, Lacorre DA, Tyrrell JA, Mitre M, Gillissen MA, Fukumura D, Jain RK, Munn LL. Simultaneous measurement of RBC velocity, flux, hematocrit and shear rate in vascular networks. Nature Methods. 7: 655-60. PMID 20581828 DOI: 10.1038/Nmeth.1475  0.377
2010 Chae SS, Kamoun WS, Farrar CT, Kirkpatrick ND, Niemeyer E, de Graaf AM, Sorensen AG, Munn LL, Jain RK, Fukumura D. Angiopoietin-2 interferes with anti-VEGFR2-induced vessel normalization and survival benefit in mice bearing gliomas. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 3618-27. PMID 20501615 DOI: 10.1158/1078-0432.Ccr-09-3073  0.312
2010 Duda DG, Willett CG, Ancukiewicz M, di Tomaso E, Shah M, Czito BG, Bentley R, Poleski M, Lauwers GY, Carroll M, Tyler D, Mantyh C, Shellito P, Clark JW, Jain RK. Plasma soluble VEGFR-1 is a potential dual biomarker of response and toxicity for bevacizumab with chemoradiation in locally advanced rectal cancer. The Oncologist. 15: 577-83. PMID 20484123 DOI: 10.1634/Theoncologist.2010-0029  0.308
2010 Batchelor TT, Duda DG, di Tomaso E, Ancukiewicz M, Plotkin SR, Gerstner E, Eichler AF, Drappatz J, Hochberg FH, Benner T, Louis DN, Cohen KS, Chea H, Exarhopoulos A, Loeffler JS, ... ... Jain RK, et al. Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 28: 2817-23. PMID 20458050 DOI: 10.1200/Jco.2009.26.3988  0.309
2010 Wong HK, Lahdenranta J, Kamoun WS, Chan AW, McClatchey AI, Plotkin SR, Jain RK, di Tomaso E. Anti-vascular endothelial growth factor therapies as a novel therapeutic approach to treating neurofibromatosis-related tumors. Cancer Research. 70: 3483-93. PMID 20406973 DOI: 10.1158/0008-5472.Can-09-3107  0.402
2010 Gerstner ER, Chen PJ, Wen PY, Jain RK, Batchelor TT, Sorensen G. Infiltrative patterns of glioblastoma spread detected via diffusion MRI after treatment with cediranib. Neuro-Oncology. 12: 466-72. PMID 20406897 DOI: 10.1093/Neuonc/Nop051  0.383
2010 Fukumura D, Duda DG, Munn LL, Jain RK. Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models. Microcirculation (New York, N.Y. : 1994). 17: 206-25. PMID 20374484 DOI: 10.1111/J.1549-8719.2010.00029.X  0.409
2010 Farrar CT, Kamoun WS, Ley CD, Kim YR, Kwon SJ, Dai G, Rosen BR, di Tomaso E, Jain RK, Sorensen AG. In vivo validation of MRI vessel caliber index measurement methods with intravital optical microscopy in a U87 mouse brain tumor model. Neuro-Oncology. 12: 341-50. PMID 20308312 DOI: 10.1093/Neuonc/Nop032  0.359
2010 Jain RK, Wei J, Gullino PM. Pharmacokinetics of methotrexate in solid tumors. Journal of Pharmacokinetics and Biopharmaceutics. 7: 181-94. PMID 20218013 DOI: 10.1007/Bf01059737  0.495
2010 Allen PM, Liu W, Chauhan VP, Lee J, Ting AY, Fukumura D, Jain RK, Bawendi MG. InAs(ZnCdS) quantum dots optimized for biological imaging in the near-infrared. Journal of the American Chemical Society. 132: 470-1. PMID 20025222 DOI: 10.1021/Ja908250R  0.597
2010 Raut CP, Morgan JA, Quek RH, Boucher Y, Duda GD, Lahdenranta J, Ancukiewicz M, Eder JP, Jain RK, Demetri GD. Measurement of interstitial fluid pressure (IFP) and circulating biomarkers in soft tissue sarcoma (STS): An exploratory phase II clinical and correlative study of sorafenib (SOR) in patients with refractory STS (NCI Protocol 6948). Journal of Clinical Oncology. 28: 10091-10091. DOI: 10.1200/Jco.2010.28.15_Suppl.10091  0.334
2010 Yoon SS, Chen Y, Karl D, Choy E, Harmon DC, Kambadakone A, Sahani D, Duda DG, Jain RK, DeLaney TF. A phase II study of neoadjuvant bevacizumab and radiation therapy for resectable soft tissue sarcomas. Journal of Clinical Oncology. 28: 10023-10023. DOI: 10.1200/Jco.2010.28.15_Suppl.10023  0.369
2010 Snuderl M, Kirkpatrick ND, Walsh EC, Chung E, Kamoun WS, Peterson TE, Munn LL, Duda DG, Fukumura D, Carmeliet P, Xu L, Jain RK. Abstract LB-363: Inhibition of placental growth factor (PlGF) leads to regression of medulloblastoma Cancer Research. 70. DOI: 10.1158/1538-7445.Am10-Lb-363  0.383
2010 Duda DG, Willett CG, Ancukiewicz M, Tomaso Ed, Shah M, Czito BG, Bentley R, Poleski M, Lauwers GY, Carroll M, Tyler D, Mantyh C, Shellito P, Clark JW, Jain RK. Abstract LB-213: Plasma soluble VEGFR1 is a potential dual biomarker of response and toxicity for bevacizumab with chemoradiation in locally advanced rectal cancer Cancer Research. 70. DOI: 10.1158/1538-7445.Am10-Lb-213  0.303
2010 Tse JM, Cheng G, Tyrrell JA, Wilcox-Adelman SA, Jain RK, Munn LL. Abstract 4811: Compression-induced cell distension stimulates coordinated migration of mammary carcinoma cells Cancer Research. 70: 4811-4811. DOI: 10.1158/1538-7445.Am10-4811  0.327
2010 Duyverman AM, Duda DG, Kohno M, Steller EJ, Fukumura D, Jain RK. Abstract 3847: Metastasizing host stromal cells potentiate colonization of metastatic tumors Cancer Research. 70: 3847-3847. DOI: 10.1158/1538-7445.Am10-3847  0.387
2010 Kirkpatrick ND, Jain RK. Abstract 368: In vivo vessel co-option by glioma cells following chronic anti-angiogenic treatment Cancer Research. 70: 368-368. DOI: 10.1158/1538-7445.Am10-368  0.428
2010 Liu J, Liao S, Huang Y, Jain RK, Xu L. Abstract B32: TGF-β blockade improves the distribution and efficacy of chemotherapeutic agent in breast carcinoma Clinical Cancer Research. 16. DOI: 10.1158/1078-0432.Tcmusa10-B32  0.347
2009 Chi AS, Gerstner ER, Eichler AF, Chea HK, Drappatz J, Wen PY, Ivy SP, Loeffler JS, Sorensen AG, Jain RK, Batchelor TT. Phase Ib study of cediranib in combination with daily temozolomide and radiation in patients with newly diagnosed glioblastoma. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 27: e13010. PMID 27962847 DOI: 10.1200/Jco.2009.27.15_Suppl.E13010  0.3
2009 Chung E, Yamashita H, Au P, Tannous BA, Fukumura D, Jain RK. Secreted Gaussia luciferase as a biomarker for monitoring tumor progression and treatment response of systemic metastases. Plos One. 4: e8316. PMID 20016816 DOI: 10.1371/Journal.Pone.0008316  0.356
2009 Duda DG, Ancukiewicz M, Jain RK. Biomarkers of antiangiogenic therapy: how do we move from candidate biomarkers to valid biomarkers? Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 28: 183-5. PMID 19949009 DOI: 10.1200/Jco.2009.24.8021  0.371
2009 Xu L, Duda DG, di Tomaso E, Ancukiewicz M, Chung DC, Lauwers GY, Samuel R, Shellito P, Czito BG, Lin PC, Poleski M, Bentley R, Clark JW, Willett CG, Jain RK. Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer. Cancer Research. 69: 7905-10. PMID 19826039 DOI: 10.1158/0008-5472.Can-09-2099  0.376
2009 Dawson MR, Duda DG, Chae SS, Fukumura D, Jain RK. VEGFR1 activity modulates myeloid cell infiltration in growing lung metastases but is not required for spontaneous metastasis formation. Plos One. 4: e6525. PMID 19763275 DOI: 10.1371/Journal.Pone.0006525  0.399
2009 Vakoc BJ, Lanning RM, Tyrrell JA, Padera TP, Bartlett LA, Stylianopoulos T, Munn LL, Tearney GJ, Fukumura D, Jain RK, Bouma BE. Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging. Nature Medicine. 15: 1219-23. PMID 19749772 DOI: 10.1038/Nm.1971  0.333
2009 Plotkin SR, Stemmer-Rachamimov AO, Barker FG, Halpin C, Padera TP, Tyrrell A, Sorensen AG, Jain RK, di Tomaso E. Hearing improvement after bevacizumab in patients with neurofibromatosis type 2. The New England Journal of Medicine. 361: 358-67. PMID 19587327 DOI: 10.1056/Nejmoa0902579  0.333
2009 Chauhan VP, Lanning RM, Diop-Frimpong B, Mok W, Brown EB, Padera TP, Boucher Y, Jain RK. Multiscale measurements distinguish cellular and interstitial hindrances to diffusion in vivo. Biophysical Journal. 97: 330-6. PMID 19580771 DOI: 10.1016/J.Bpj.2009.03.064  0.769
2009 Sorensen AG, Batchelor TT, Zhang WT, Chen PJ, Yeo P, Wang M, Jennings D, Wen PY, Lahdenranta J, Ancukiewicz M, di Tomaso E, Duda DG, Jain RK. A "vascular normalization index" as potential mechanistic biomarker to predict survival after a single dose of cediranib in recurrent glioblastoma patients. Cancer Research. 69: 5296-300. PMID 19549889 DOI: 10.1158/0008-5472.Can-09-0814  0.33
2009 Jain RK. A new target for tumor therapy New England Journal of Medicine. 360. PMID 19535806 DOI: 10.1056/Nejmcibr0902054  0.379
2009 Chi AS, Sorensen AG, Jain RK, Batchelor TT. Angiogenesis as a therapeutic target in malignant gliomas Oncologist. 14: 621-636. PMID 19487335 DOI: 10.1634/Theoncologist.2008-0272  0.329
2009 Jain RK, Duda DG, Willett CG, Sahani DV, Zhu AX, Loeffler JS, Batchelor TT, Sorensen AG. Biomarkers of response and resistance to antiangiogenic therapy. Nature Reviews. Clinical Oncology. 6: 327-38. PMID 19483739 DOI: 10.1038/Nrclinonc.2009.63  0.324
2009 Au P, Tam J, Duda DG, Lin PC, Munn LL, Fukumura D, Jain RK. Paradoxical effects of PDGF-BB overexpression in endothelial cells on engineered blood vessels in vivo. The American Journal of Pathology. 175: 294-302. PMID 19477947 DOI: 10.2353/Ajpath.2009.080887  0.312
2009 di Tomaso E, London N, Fuja D, Logie J, Tyrrell JA, Kamoun W, Munn LL, Jain RK. PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment. Plos One. 4: e5123. PMID 19352490 DOI: 10.1371/Journal.Pone.0005123  0.376
2009 Gerstner ER, Sorensen AG, Jain RK, Batchelor TT. Anti-vascular endothelial growth factor therapy for malignant glioma. Current Neurology and Neuroscience Reports. 9: 254-62. PMID 19348715 DOI: 10.1007/S11910-009-0037-2  0.359
2009 Gerstner ER, Duda DG, di Tomaso E, Ryg PA, Loeffler JS, Sorensen AG, Ivy P, Jain RK, Batchelor TT. VEGF inhibitors in the treatment of cerebral edema in patients with brain cancer. Nature Reviews. Clinical Oncology. 6: 229-36. PMID 19333229 DOI: 10.1038/Nrclinonc.2009.14  0.386
2009 Kamoun WS, Ley CD, Farrar CT, Duyverman AM, Lahdenranta J, Lacorre DA, Batchelor TT, di Tomaso E, Duda DG, Munn LL, Fukumura D, Sorensen AG, Jain RK. Edema control by cediranib, a vascular endothelial growth factor receptor-targeted kinase inhibitor, prolongs survival despite persistent brain tumor growth in mice. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 27: 2542-52. PMID 19332720 DOI: 10.1200/Jco.2008.19.9356  0.316
2009 Lahdenranta J, Hagendoorn J, Padera TP, Hoshida T, Nelson G, Kashiwagi S, Jain RK, Fukumura D. Endothelial nitric oxide synthase mediates lymphangiogenesis and lymphatic metastasis. Cancer Research. 69: 2801-8. PMID 19318557 DOI: 10.1158/0008-5472.Can-08-4051  0.345
2009 Mok W, Stylianopoulos T, Boucher Y, Jain RK. Mathematical modeling of herpes simplex virus distribution in solid tumors: implications for cancer gene therapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 2352-60. PMID 19318482 DOI: 10.1158/1078-0432.Ccr-08-2082  0.331
2009 Wen PY, Yung WK, Lamborn KR, Norden AD, Cloughesy TF, Abrey LE, Fine HA, Chang SM, Robins HI, Fink K, Deangelis LM, Mehta M, Di Tomaso E, Drappatz J, Kesari S, ... ... Jain RK, et al. Phase II study of imatinib mesylate for recurrent meningiomas (North American Brain Tumor Consortium study 01-08). Neuro-Oncology. 11: 853-60. PMID 19293394 DOI: 10.1215/15228517-2009-010  0.303
2009 Perentes JY, Duda DG, Jain RK. Visualizing anti-tumor immune responses in vivo. Disease Models & Mechanisms. 2: 107-10. PMID 19259379 DOI: 10.1242/Dmm.001842  0.372
2009 Cheng G, Tse J, Jain RK, Munn LL. Micro-environmental mechanical stress controls tumor spheroid size and morphology by suppressing proliferation and inducing apoptosis in cancer cells. Plos One. 4: e4632. PMID 19247489 DOI: 10.1371/Journal.Pone.0004632  0.342
2009 Pieters A, Duda D, Steller E, Fukumura D, Jain R. The Role of Stromal Cells in Tumor Metastases. Cancer Research. 69: 6151-6151. DOI: 10.1158/0008-5472.Sabcs-09-6151  0.373
2009 Duyverman A, Duda DG, Steller EJA, Fukumura D, Jain RK. Abstract C57: The role of stromal cells in tumor metastases Cancer Research. 69. DOI: 10.1158/0008-5472.Fbcr09-C57  0.404
2008 Gerstner ER, Sorensen AG, Jain RK, Batchelor TT. Advances in neuroimaging techniques for the evaluation of tumor growth, vascular permeability, and angiogenesis in gliomas. Current Opinion in Neurology. 21: 728-735. PMID 18989120 DOI: 10.1097/Wco.0B013E328318402A  0.378
2008 Fukumura D, Jain RK. Imaging angiogenesis and the microenvironment. Apmis : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. 116: 695-715. PMID 18834413 DOI: 10.1111/J.1600-0463.2008.01148.X  0.414
2008 Padera TP, Kuo AH, Hoshida T, Liao S, Lobo J, Kozak KR, Fukumura D, Jain RK. Differential response of primary tumor versus lymphatic metastasis to VEGFR-2 and VEGFR-3 kinase inhibitors cediranib and vandetanib. Molecular Cancer Therapeutics. 7: 2272-9. PMID 18687659 DOI: 10.1158/1535-7163.Mct-08-0182  0.377
2008 Nagano S, Perentes JY, Jain RK, Boucher Y. Cancer cell death enhances the penetration and efficacy of oncolytic herpes simplex virus in tumors. Cancer Research. 68: 3795-802. PMID 18483263 DOI: 10.1158/0008-5472.Can-07-6193  0.369
2008 Kashiwagi S, Tsukada K, Xu L, Miyazaki J, Kozin SV, Tyrrell JA, Sessa WC, Gerweck LE, Jain RK, Fukumura D. Perivascular nitric oxide gradients normalize tumor vasculature. Nature Medicine. 14: 255-7. PMID 18278052 DOI: 10.1038/Nm1730  0.381
2008 Jain RK. Taming vessels to treat cancer Scientific American. 298: 56-63. PMID 18225696 DOI: 10.1038/Scientificamerican0108-56  0.383
2008 Gerstner ER, Duda DG, di Tomaso E, Sorensen G, Jain RK, Batchelor TT. Antiangiogenic agents for the treatment of glioblastoma. Expert Opinion On Investigational Drugs. 16: 1895-908. PMID 18041999 DOI: 10.1517/13543784.16.12.1895  0.308
2008 Zuniga RM, Torcuator R, Doyle T, Anderson J, Jain R, Orley J, Rosenblum M, Mikkelsen T. Retrospective analysis of patterns of recurrence seen on MRI in patients with recurrent glioblastoma multiforme treated with bevacizumab plus irinotecan Journal of Clinical Oncology. 26: 13013-13013. DOI: 10.1200/Jco.2008.26.15_Suppl.13013  0.312
2007 Nelson GM, Padera TP, Garkavtsev I, Shioda T, Jain RK. Differential gene expression of primary cultured lymphatic and blood vascular endothelial cells. Neoplasia (New York, N.Y.). 9: 1038-45. PMID 18084611 DOI: 10.1593/Neo.07643  0.323
2007 Mok W, Boucher Y, Jain RK. Matrix metalloproteinases-1 and -8 improve the distribution and efficacy of an oncolytic virus. Cancer Research. 67: 10664-8. PMID 18006807 DOI: 10.1158/0008-5472.Can-07-3107  0.355
2007 Jain RK, Xu L. alphaPlGF: a new kid on the antiangiogenesis block. Cell. 131: 443-5. PMID 17981110 DOI: 10.1016/J.Cell.2007.10.023  0.344
2007 Sun C, Jain RK, Munn LL. Non-uniform plasma leakage affects local hematocrit and blood flow: implications for inflammation and tumor perfusion. Annals of Biomedical Engineering. 35: 2121-9. PMID 17846892 DOI: 10.1007/S10439-007-9377-8  0.361
2007 Jain RK, Finn AV, Kolodgie FD, Gold HK, Virmani R. Antiangiogenic therapy for normalization of atherosclerotic plaque vasculature: a potential strategy for plaque stabilization. Nature Clinical Practice. Cardiovascular Medicine. 4: 491-502. PMID 17712362 DOI: 10.1038/Ncpcardio0979  0.321
2007 Xu L, Jain RK. Down-regulation of placenta growth factor by promoter hypermethylation in human lung and colon carcinoma. Molecular Cancer Research : McR. 5: 873-80. PMID 17704140 DOI: 10.1158/1541-7786.Mcr-06-0141  0.329
2007 Jain RK, di Tomaso E, Duda DG, Loeffler JS, Sorensen AG, Batchelor TT. Angiogenesis in brain tumours. Nature Reviews. Neuroscience. 8: 610-22. PMID 17643088 DOI: 10.1038/Nrn2175  0.321
2007 Fukumura D, Jain RK. Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization. Microvascular Research. 74: 72-84. PMID 17560615 DOI: 10.1016/J.Mvr.2007.05.003  0.416
2007 Kozin SV, Winkler F, Garkavtsev I, Hicklin DJ, Jain RK, Boucher Y. Human tumor xenografts recurring after radiotherapy are more sensitive to anti-vascular endothelial growth factor receptor-2 treatment than treatment-naive tumors. Cancer Research. 67: 5076-82. PMID 17545583 DOI: 10.1158/0008-5472.Can-06-3664  0.41
2007 Duda DG, Batchelor TT, Willett CG, Jain RK. VEGF-targeted cancer therapy strategies: current progress, hurdles and future prospects. Trends in Molecular Medicine. 13: 223-230. PMID 17462954 DOI: 10.1016/J.Molmed.2007.04.001  0.308
2007 Jain RK, Tong RT, Munn LL. Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model. Cancer Research. 67: 2729-35. PMID 17363594 DOI: 10.1158/0008-5472.Can-06-4102  0.419
2007 Lawenda BD, Smith DE, Xu L, Niemierko A, Silverstein JR, Boucher Y, Kashiwagi S, Held KD, Jain RK, Loeffler JS, Eisenberg DM, Blumberg JB. Do the dietary supplements epigallocatechin gallate or vitamin e cause a radiomodifying response on tumors in vivo? A pilot study with murine breast carcinoma. Journal of the Society For Integrative Oncology. 5: 11-7. PMID 17309809 DOI: 10.2310/7200.2006.033  0.383
2007 Batchelor TT, Sorensen AG, di Tomaso E, Zhang WT, Duda DG, Cohen KS, Kozak KR, Cahill DP, Chen PJ, Zhu M, Ancukiewicz M, Mrugala MM, Plotkin S, Drappatz J, Louis DN, ... ... Jain RK, et al. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell. 11: 83-95. PMID 17222792 DOI: 10.1016/J.Ccr.2006.11.021  0.396
2007 Fukumura D, Jain RK. Tumor microenvironment abnormalities: causes, consequences, and strategies to normalize. Journal of Cellular Biochemistry. 101: 937-49. PMID 17171643 DOI: 10.1002/Jcb.21187  0.423
2007 Hoshida T, Isaka N, Hagendoorn J, di Tomaso E, Chen YL, Pytowski B, Fukumura D, Padera TP, Jain RK. Imaging steps of lymphatic metastasis reveals that vascular endothelial growth factor-C increases metastasis by increasing delivery of cancer cells to lymph nodes: therapeutic implications. Cancer Research. 66: 8065-75. PMID 16912183 DOI: 10.1158/0008-5472.Can-06-1392  0.333
2007 Ditomaso E, Stemmer-Rachamimov A, Potts A, Drottar M, Jain RK, Plotkin SR. Correlation between VEGF expression and MVD in sporadic and NF2-related schwannomas Journal of Clinical Oncology. 25: 2083-2083. DOI: 10.1200/Jco.2007.25.18_Suppl.2083  0.346
2007 Batchelor T, Sorensen AG, Ancukiewicz M, Duda DG, Louis DN, Plotkin SR, Ivy P, Wen PY, Loeffler JS, Jain R. A phase II trial of AZD2171 (cediranib), an oral pan-VEGF receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma Journal of Clinical Oncology. 25: 2001-2001. DOI: 10.1200/Jco.2007.25.18_Suppl.2001  0.307
2007 Batchelor T, Duda D, di Tomaso E, Kozak K, Zhang W, Ancukiewicz M, Loeffler J, Wen P, Sorensen G, Jain R. Normalization of Tumor Vasculature and Alleviation of Edema by AZD2171, A Pan-VEGF Receptor Tyrosine Kinase Inhibitor in Glioblastoma Patients International Journal of Radiation Oncology*Biology*Physics. 69: S50-S51. DOI: 10.1016/J.Ijrobp.2007.07.092  0.326
2007 Willett CG, Duda DG, Jain RK. Surrogate biomarkers for anti-angiogenic therapy for advanced colorectal cancer Current Colorectal Cancer Reports. 3: 94-98. DOI: 10.1007/S11888-007-0007-5  0.395
2006 Willett CG, Kozin SV, Duda DG, di Tomaso E, Kozak KR, Boucher Y, Jain RK. Combined vascular endothelial growth factor-targeted therapy and radiotherapy for rectal cancer: theory and clinical practice. Seminars in Oncology. 33: S35-40. PMID 17145523 DOI: 10.1053/J.Seminoncol.2006.08.007  0.378
2006 Reddy ST, Berk DA, Jain RK, Swartz MA. A sensitive in vivo model for quantifying interstitial convective transport of injected macromolecules and nanoparticles. Journal of Applied Physiology (Bethesda, Md. : 1985). 101: 1162-9. PMID 16763103 DOI: 10.1152/Japplphysiol.00389.2006  0.421
2006 Xu L, Cochran DM, Tong RT, Winkler F, Kashiwagi S, Jain RK, Fukumura D. Placenta growth factor overexpression inhibits tumor growth, angiogenesis, and metastasis by depleting vascular endothelial growth factor homodimers in orthotopic mouse models. Cancer Research. 66: 3971-7. PMID 16618713 DOI: 10.1158/0008-5472.Can-04-3085  0.399
2006 Hagendoorn J, Tong R, Fukumura D, Lin Q, Lobo J, Padera TP, Xu L, Kucherlapati R, Jain RK. Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis. Cancer Research. 66: 3360-4. PMID 16585153 DOI: 10.1158/0008-5472.Can-05-2655  0.315
2006 Duda DG, Cohen KS, di Tomaso E, Au P, Klein RJ, Scadden DT, Willett CG, Jain RK. Differential CD146 expression on circulating versus tissue endothelial cells in rectal cancer patients: implications for circulating endothelial and progenitor cells as biomarkers for antiangiogenic therapy. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 24: 1449-53. PMID 16549839 DOI: 10.1200/Jco.2005.04.2861  0.302
2006 McKee TD, Grandi P, Mok W, Alexandrakis G, Insin N, Zimmer JP, Bawendi MG, Boucher Y, Breakefield XO, Jain RK. Degradation of fibrillar collagen in a human melanoma xenograft improves the efficacy of an oncolytic herpes simplex virus vector. Cancer Research. 66: 2509-13. PMID 16510565 DOI: 10.1158/0008-5472.Can-05-2242  0.35
2006 Jain RK, Duda DG, Clark JW, Loeffler JS. Lessons from phase III clinical trials on anti-VEGF therapy for cancer. Nature Clinical Practice. Oncology. 3: 24-40. PMID 16407877 DOI: 10.1038/Ncponc0403  0.353
2006 Duda DG, Cohen KS, Kozin SV, Perentes JY, Fukumura D, Scadden DT, Jain RK. Evidence for incorporation of bone marrow-derived endothelial cells into perfused blood vessels in tumors. Blood. 107: 2774-6. PMID 16339405 DOI: 10.1182/Blood-2005-08-3210  0.361
2006 Nagano S, Perentes JY, Jain RK, Boucher Y. 45. Paclitaxel-TRAIL Enhances the Distribution of Oncolytic Herpes Simplex Virus-1 in a Human Mammary Carcinoma Xenograft Molecular Therapy. 13: S19. DOI: 10.1016/J.Ymthe.2006.08.059  0.381
2005 Acker T, Diez-Juan A, Aragones J, Tjwa M, Brusselmans K, Moons L, Fukumura D, Moreno-Murciano MP, Herbert JM, Burger A, Riedel J, Elvert G, Flamme I, Maxwell PH, Collen D, ... ... Jain RK, et al. Genetic evidence for a tumor suppressor role of HIF-2alpha. Cancer Cell. 8: 131-41. PMID 16098466 DOI: 10.1016/J.Ccr.2005.07.003  0.334
2005 di Tomaso E, Capen D, Haskell A, Hart J, Logie JJ, Jain RK, McDonald DM, Jones R, Munn LL. Mosaic tumor vessels: cellular basis and ultrastructure of focal regions lacking endothelial cell markers. Cancer Research. 65: 5740-9. PMID 15994949 DOI: 10.1158/0008-5472.Can-04-4552  0.333
2005 Demou ZN, Awad M, McKee T, Perentes JY, Wang X, Munn LL, Jain RK, Boucher Y. Lack of telopeptides in fibrillar collagen I promotes the invasion of a metastatic breast tumor cell line. Cancer Research. 65: 5674-82. PMID 15994941 DOI: 10.1158/0008-5472.Can-04-1682  0.314
2005 Kashiwagi S, Izumi Y, Gohongi T, Demou ZN, Xu L, Huang PL, Buerk DG, Munn LL, Jain RK, Fukumura D. NO mediates mural cell recruitment and vessel morphogenesis in murine melanomas and tissue-engineered blood vessels. The Journal of Clinical Investigation. 115: 1816-27. PMID 15951843 DOI: 10.1172/Jci24015  0.31
2005 Stroh M, Zimmer JP, Duda DG, Levchenko TS, Cohen KS, Brown EB, Scadden DT, Torchilin VP, Bawendi MG, Fukumura D, Jain RK. Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo. Nature Medicine. 11: 678-82. PMID 15880117 DOI: 10.1038/Nm1247  0.36
2005 Jain RK. Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy Science. 307: 58-62. PMID 15637262 DOI: 10.1126/Science.1104819  0.406
2004 Willett CG, Chung D, Sahani D, Mino M, Clark J, Ryan D, Zhu A, Blaszkowski L, Lauwers G, Jain R. Phase I study of neoadjuvant bevacizumab, 5-fluorouracil, and radiation therapy followed by surgery for patients with primary rectal cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 22: 3589. PMID 28016318 DOI: 10.1200/Jco.2004.22.90140.3589  0.316
2004 Lawenda BD, Smith DE, Niemierko A, Xu L, Silverstein JR, Held KD, Loeffler JS, Jain RK, Blumberg JB. Radiomodifying responses of vitamin E and epigallocatechin gallate supplementation during irradiation of implanted tumors. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 22: 9601. PMID 28016194 DOI: 10.1200/Jco.2004.22.14_Suppl.9601  0.31
2004 Winkler F, Kozin SV, Tong RT, Chae SS, Booth MF, Garkavtsev I, Xu L, Hicklin DJ, Fukumura D, di Tomaso E, Munn LL, Jain RK. Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases. Cancer Cell. 6: 553-63. PMID 15607960 DOI: 10.1016/J.Ccr.2004.10.011  0.366
2004 Duda DG, Fukumura D, Munn LL, Booth MF, Brown EB, Huang P, Seed B, Jain RK. Differential transplantability of tumor-associated stromal cells. Cancer Research. 64: 5920-4. PMID 15342367 DOI: 10.1158/0008-5472.Can-04-1268  0.362
2004 Isaka N, Padera TP, Hagendoorn J, Fukumura D, Jain RK. Peritumor lymphatics induced by vascular endothelial growth factor-C exhibit abnormal function. Cancer Research. 64: 4400-4. PMID 15231646 DOI: 10.1158/0008-5472.Can-04-0752  0.347
2004 Tong RT, Boucher Y, Kozin SV, Winkler F, Hicklin DJ, Jain RK. Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Research. 64: 3731-6. PMID 15172975 DOI: 10.1158/0008-5472.Can-04-0074  0.378
2004 Brown EB, Boucher Y, Nasser S, Jain RK. Measurement of macromolecular diffusion coefficients in human tumors. Microvascular Research. 67: 231-6. PMID 15121448 DOI: 10.1016/J.Mvr.2004.02.001  0.333
2004 Bockhorn M, Roberge S, Sousa C, Jain RK, Munn LL. Differential gene expression in metastasizing cells shed from kidney tumors. Cancer Research. 64: 2469-73. PMID 15059900 DOI: 10.1158/0008-5472.Can-03-0256  0.367
2004 Padera TP, Stoll BR, Tooredman JB, Capen D, di Tomaso E, Jain RK. Pathology: cancer cells compress intratumour vessels. Nature. 427: 695. PMID 14973470 DOI: 10.1038/427695A  0.328
2004 Willett CG, Boucher Y, di Tomaso E, Duda DG, Munn LL, Tong RT, Chung DC, Sahani DV, Kalva SP, Kozin SV, Mino M, Cohen KS, Scadden DT, Hartford AC, Fischman AJ, ... ... Jain RK, et al. Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nature Medicine. 10: 145-7. PMID 14745444 DOI: 10.1038/Nm988  0.364
2004 Alexandrakis G, Brown EB, Tong RT, McKee TD, Campbell RB, Boucher Y, Jain RK. Two-photon fluorescence correlation microscopy reveals the two-phase nature of transport in tumors. Nature Medicine. 10: 203-7. PMID 14716306 DOI: 10.1038/Nm981  0.358
2004 Jain RK, Duda DG. Role of bone marrow-derived cells in tumor angiogenesis and treatment. Cancer Cell. 3: 515-6. PMID 12842078 DOI: 10.1016/S1535-6108(03)00138-7  0.361
2004 Gohongi T, Todoroki T, Fukumura D, Jain RK. Influence of the site of human gallbladder xenograft (Mz-ChA-1) on angiogenesis at the distant site Oncology Reports. 11: 803-807. DOI: 10.3892/Or.11.4.803  0.358
2004 Jain RK. Reply to 'Recognition of tumor blood vessel normalization as a new antiangiogenic concept' Nature Medicine. 10: 329-330. DOI: 10.1038/Nm0404-329B  0.348
2004 Tyrrell JA, Mahadevan V, Tong R, Roysam B, Brown EB, Jain RK. Robust parametric modeling for improved segmentation of complex tumor microvasculature from multiphoton microscopy data Microscopy and Microanalysis. 10: 176-177. DOI: 10.1017/S1431927604885787  0.317
2003 Roose T, Netti PA, Munn LL, Boucher Y, Jain RK. Solid stress generated by spheroid growth estimated using a linear poroelasticity model. Microvascular Research. 66: 204-12. PMID 14609526 DOI: 10.1016/S0026-2862(03)00057-8  0.383
2003 Jain RK, Booth MF. What brings pericytes to tumor vessels? The Journal of Clinical Investigation. 112: 1134-6. PMID 14561696 DOI: 10.1172/Jci20087  0.321
2003 Fukumura D, Ushiyama A, Duda DG, Xu L, Tam J, Krishna V, Chatterjee K, Garkavtsev I, Jain RK. Paracrine regulation of angiogenesis and adipocyte differentiation during in vivo adipogenesis. Circulation Research. 93: e88-97. PMID 14525808 DOI: 10.1161/01.Res.0000099243.20096.Fa  0.307
2003 Jain RK. Molecular regulation of vessel maturation Nature Medicine. 9: 685-693. PMID 12778167 DOI: 10.1038/Nm0603-685  0.335
2003 Stoll BR, Migliorini C, Kadambi A, Munn LL, Jain RK. A mathematical model of the contribution of endothelial progenitor cells to angiogenesis in tumors: implications for antiangiogenic therapy. Blood. 102: 2555-61. PMID 12775571 DOI: 10.1182/Blood-2003-02-0365  0.396
2003 Brown E, McKee T, diTomaso E, Pluen A, Seed B, Boucher Y, Jain RK. Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation. Nature Medicine. 9: 796-800. PMID 12754503 DOI: 10.1038/Nm879  0.361
2003 Mollica F, Jain RK, Netti PA. A model for temporal heterogeneities of tumor blood flow. Microvascular Research. 65: 56-60. PMID 12535873 DOI: 10.1016/S0026-2862(02)00012-2  0.385
2003 Friedrich SW, Lin SC, Stoll BR, Baxter LT, Munn LL, Jain RK. Antibody-directed effector cell therapy of tumors: analysis and optimization using a physiologically based pharmacokinetic model. Neoplasia (New York, N.Y.). 4: 449-63. PMID 12192604 DOI: 10.1038/Sj.Neo.7900260  0.378
2003 Abdul-Karim MA, Al-Kofahi O, Brown EB, Jain RK, Al-Kofahi K, Roysam B. Automated in vivo change analysis of tumor vasculature from two-photon confocal image time series Proceedings of Spie - the International Society For Optical Engineering. 4963: 151-159. DOI: 10.1117/12.477991  0.322
2002 Padera TP, Stoll BR, So PT, Jain RK. Conventional and high-speed intravital multiphoton laser scanning microscopy of microvasculature, lymphatics, and leukocyte-endothelial interactions. Molecular Imaging. 1: 9-15. PMID 12920856 DOI: 10.1162/153535002753395662  0.312
2002 Jain RK. Angiogenesis and lymphangiogenesis in tumors: Insights from intravital microscopy Cold Spring Harbor Symposia On Quantitative Biology. 67: 239-248. PMID 12858546 DOI: 10.1101/Sqb.2002.67.239  0.385
2002 Jain RK. Tumor angiogenesis and accessibility: role of vascular endothelial growth factor Seminars in Oncology. 29: 3-9. PMID 12516032 DOI: 10.1016/S0093-7754(02)70063-8  0.412
2002 Ramanujan S, Pluen A, McKee TD, Brown EB, Boucher Y, Jain RK. Diffusion and convection in collagen gels: implications for transport in the tumor interstitium. Biophysical Journal. 83: 1650-60. PMID 12202388 DOI: 10.1016/S0006-3495(02)73933-7  0.327
2002 Jain RK, Padera TP. Prevention and treatment of lymphatic metastasis by antilymphangiogenic therapy. Journal of the National Cancer Institute. 94: 785-7. PMID 12048260 DOI: 10.1093/Jnci/94.11.785  0.389
2002 Padera TP, Kadambi A, di Tomaso E, Carreira CM, Brown EB, Boucher Y, Choi NC, Mathisen D, Wain J, Mark EJ, Munn LL, Jain RK. Lymphatic metastasis in the absence of functional intratumor lymphatics. Science (New York, N.Y.). 296: 1883-6. PMID 11976409 DOI: 10.1126/Science.1071420  0.386
2002 Melder RJ, Munn LL, Stoll BR, Marecos EM, Baxter LT, Weissleder R, Jain RK. Systemic distribution and tumor localization of adoptively transferred lymphocytes in mice: comparison with physiologically based pharmacokinetic model. Neoplasia (New York, N.Y.). 4: 3-8. PMID 11922388 DOI: 10.1038/Sj.Neo.7900209  0.377
2002 Morikawa S, Baluk P, Kaidoh T, Haskell A, Jain RK, McDonald DM. Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors. The American Journal of Pathology. 160: 985-1000. PMID 11891196 DOI: 10.1016/S0002-9440(10)64920-6  0.388
2002 Hartford A, Fukumura D, Jain R. Systemic levels of VEGF and endostatin are influenced by tumor, host, and treatment factors International Journal of Radiation Oncology*Biology*Physics. 54: 28. DOI: 10.1016/S0360-3016(02)03105-X  0.329
2001 Jain RK, Forbes NS. Can engineered bacteria help control cancer? Proceedings of the National Academy of Sciences of the United States of America. 98: 14748-50. PMID 11752416 DOI: 10.1073/Pnas.261606598  0.387
2001 Tsuzuki Y, Carreira CM, Bockhorn M, Xu L, Jain RK, Fukumura D. Pancreas microenvironment promotes VEGF expression and tumor growth: Novel window models for pancreatic tumor angiogenesis and microcirculation Laboratory Investigation. 81: 1439-1451. PMID 11598156 DOI: 10.1038/Labinvest.3780357  0.416
2001 Patan S, Tanda S, Roberge S, Jones RC, Jain RK, Munn LL. Vascular morphogenesis and remodeling in a human tumor xenograft: blood vessel formation and growth after ovariectomy and tumor implantation. Circulation Research. 89: 732-9. PMID 11597997 DOI: 10.1161/Hh2001.097872  0.384
2001 Jain RK. Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy Nature Medicine. 7: 987-989. PMID 11533692 DOI: 10.1038/Nm0901-987  0.362
2001 Jain RK. Delivery of molecular medicine to solid tumors: Lessons from in vivo imaging of gene expression and function Journal of Controlled Release. 74: 7-25. PMID 11489479 DOI: 10.1016/S0168-3659(01)00306-6  0.406
2001 Brown EB, Campbell RB, Tsuzuki Y, Xu L, Carmeliet P, Fukumura D, Jain RK. In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy. Nature Medicine. 7: 864-8. PMID 11433354 DOI: 10.1038/89997  0.375
2001 Losken A, Swartz MA, Van Den Abbeele AD, Jain RK, Slavin SA. A potential murine model for flap-related investigations. Plastic and Reconstructive Surgery. 107: 1504-8. PMID 11335827 DOI: 10.1097/00006534-200105000-00032  0.389
2001 Pluen A, Boucher Y, Ramanujan S, McKee TD, Gohongi T, di Tomaso E, Brown EB, Izumi Y, Campbell RB, Berk DA, Jain RK. Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors. Proceedings of the National Academy of Sciences of the United States of America. 98: 4628-33. PMID 11274375 DOI: 10.1073/Pnas.081626898  0.377
2001 Jain RK. Delivery of molecular and cellular medicine to solid tumors. Advanced Drug Delivery Reviews. 46: 149-68. PMID 11259838 DOI: 10.1016/S0169-409X(00)00131-9  0.413
2001 Chang YS, di Tomaso E, McDonald DM, Jones R, Jain RK, Munn LL. Mosaic blood vessels in tumors: frequency of cancer cells in contact with flowing blood. Proceedings of the National Academy of Sciences of the United States of America. 97: 14608-13. PMID 11121063 DOI: 10.1073/Pnas.97.26.14608  0.392
2001 Hartford A, Gohongi T, Fukumura D, Jain R. Primary tumor irradiation affects levels of systemic angiogenic agents: potential roles for both tumor and host tissues International Journal of Radiation Oncology*Biology*Physics. 51: 190-191. DOI: 10.1016/S0360-3016(01)02169-1  0.366
2001 Tsuzuki Y, Fukumura D, Jain RK. Tumor-host interaction modulates production of antiangiogenic factors from human pancreatic cancer Gastroenterology. 120: A4-A5. DOI: 10.1016/S0016-5085(08)80022-4  0.327
2000 Kristensen CA, Hamberg LM, Hunter GJ, Roberge S, Kierstead D, Wolf GL, Jain RK. Changes in vascularization of human breast cancer xenografts responding to antiestrogen therapy. Neoplasia (New York, N.Y.). 1: 518-25. PMID 10935499 DOI: 10.1038/Sj.Neo.7900063  0.368
2000 Hashizume H, Baluk P, Morikawa S, McLean JW, Thurston G, Roberge S, Jain RK, McDonald DM. Openings between defective endothelial cells explain tumor vessel leakiness. The American Journal of Pathology. 156: 1363-80. PMID 10751361 DOI: 10.1016/S0002-9440(10)65006-7  0.403
2000 McDonald DM, Munn L, Jain RK. Vasculogenic mimicry: how convincing, how novel, and how significant? The American Journal of Pathology. 156: 383-8. PMID 10666365 DOI: 10.1016/S0002-9440(10)64740-2  0.345
2000 Huang B, Jain RK, Locke RD, Alderfer JL, Tabaczynski WA, Matta KL. First total synthesis of sialylated and sulfated Lewisx mucin Core 2 structures as potential tumor associated antigens Tetrahedron Letters. 41: 6279-6284. DOI: 10.1016/S0040-4039(00)00975-8  0.316
2000 Tsuzuki Y, Fukumura D, Koike C, Jain RK. The orthotopic microenvironment promotes tumor growth and VEGF121 expression in human pancreatic adenocarcinoma Gastroenterology. 118: A1415. DOI: 10.1016/S0016-5085(00)81547-4  0.354
1999 Chandrasekaran EV, Jain RK, Rhodes JM, Chawda R, Piskorz C, Matta KL. Characterization of distinct Gal:3-O-sulfotransferase activities in human tumor epithelial cell lines and of calf lymph node GlcNAc : 6-O-sulfotransferase activity. Glycoconjugate Journal. 16: 523-36. PMID 10815989 DOI: 10.1023/A:1007074005371  0.328
1999 Swartz MA, Kaipainen A, Netti PA, Brekken C, Boucher Y, Grodzinsky AJ, Jain RK. Mechanics of interstitial-lymphatic fluid transport: theoretical foundation and experimental validation. Journal of Biomechanics. 32: 1297-307. PMID 10569708 DOI: 10.1016/S0021-9290(99)00125-6  0.573
1999 Gohongi T, Fukumura D, Boucher Y, Yun CO, Soff GA, Compton C, Todoroki T, Jain RK. Tumor-host interactions in the gallbladder suppress distal angiogenesis and tumor growth: involvement of transforming growth factor beta1. Nature Medicine. 5: 1203-8. PMID 10502827 DOI: 10.1038/13524  0.383
1999 Endo M, Jain RK, Witwer B, Brown D. Water channel (aquaporin 1) expression and distribution in mammary carcinomas and glioblastomas. Microvascular Research. 58: 89-98. PMID 10458924 DOI: 10.1006/Mvre.1999.2158  0.349
1999 Lichtenbeld HC, Ferarra N, Jain RK, Munn LL. Effect of local anti-VEGF antibody treatment on tumor microvessel permeability. Microvascular Research. 57: 357-62. PMID 10329263 DOI: 10.1006/Mvre.1998.2140  0.385
1999 Netti PA, Hamberg LM, Babich JW, Kierstead D, Graham W, Hunter GJ, Wolf GL, Fischman A, Boucher Y, Jain RK. Enhancement of fluid filtration across tumor vessels: implication for delivery of macromolecules. Proceedings of the National Academy of Sciences of the United States of America. 96: 3137-42. PMID 10077650 DOI: 10.1073/Pnas.96.6.3137  0.399
1999 Slavin SA, Van den Abbeele AD, Losken A, Swartz MA, Jain RK. Return of lymphatic function after flap transfer for acute lymphedema. Annals of Surgery. 229: 421-7. PMID 10077056 DOI: 10.1097/00000658-199903000-00017  0.395
1998 Fukumura D, Xavier R, Sugiura T, Chen Y, Park EC, Lu N, Selig M, Nielsen G, Taksir T, Jain RK, Seed B. Tumor induction of VEGF promoter activity in stromal cells. Cell. 94: 715-25. PMID 9753319 DOI: 10.1016/S0092-8674(00)81731-6  0.391
1998 Jain RK. Delivery of molecular and cellular medicine to solid tumors Journal of Controlled Release. 53: 49-67. PMID 9741913 DOI: 10.1016/S0168-3659(97)00237-X  0.388
1998 Jain RK, Safabakhsh N, Sckell A, Chen Y, Jiang P, Benjamin L, Yuan F, Keshet E. Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: role of vascular endothelial growth factor. Proceedings of the National Academy of Sciences of the United States of America. 95: 10820-5. PMID 9724788 DOI: 10.1073/Pnas.95.18.10820  0.404
1998 Detmar M, Brown LF, Schön MP, Elicker BM, Velasco P, Richard L, Fukumura D, Monsky W, Claffey KP, Jain RK. Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice. The Journal of Investigative Dermatology. 111: 1-6. PMID 9665379 DOI: 10.1046/J.1523-1747.1998.00262.X  0.305
1998 Fukumura D, Jain RK. Role of nitric oxide in angiogenesis and microcirculation in tumors. Cancer Metastasis Reviews. 17: 77-89. PMID 9544424 DOI: 10.1023/A:1005908805527  0.403
1998 Hobbs SK, Monsky WL, Yuan F, Roberts WG, Griffith L, Torchilin VP, Jain RK. Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. Proceedings of the National Academy of Sciences of the United States of America. 95: 4607-12. PMID 9539785 DOI: 10.1073/Pnas.95.8.4607  0.574
1998 Gazit Y, Baish JW, Safabakhsh N, Leunig M, Baxter LT, Jain RK. Fractal characteristics of tumor vascular architecture during tumor growth and regression. Microcirculation (New York, N.Y. : 1994). 4: 395-402. PMID 9431507 DOI: 10.3109/10739689709146803  0.381
1998 Hartford AC, Gohongi T, Fukumura D, Jain RK. Irradiation of a primary tumor enhances inhibition of angiogenesis induced at a secondary site International Journal of Radiation Oncology*Biology*Physics. 42: 169. DOI: 10.1016/S0360-3016(98)80191-0  0.341
1997 Griffon-Etienne G, Boucher Y, Jain RK, Suit HD. Effects of needle insertion in tumors on interstitial fluid pressure. Microvascular Research. 54: 174-7. PMID 9327388 DOI: 10.1006/Mvre.1997.2037  0.316
1997 Nozue M, Lee I, Yuan F, Teicher BA, Brizel DM, Dewhirst MW, Milross CC, Milas L, Song CW, Thomas CD, Guichard M, Evans SM, Koch CJ, Lord EM, Jain RK, et al. Interlaboratory variation in oxygen tension measurement by Eppendorf 'Histograph' and comparison with hypoxic marker Journal of Surgical Oncology. 66: 30-38. PMID 9290690 DOI: 10.1002/(Sici)1096-9098(199709)66:1<30::Aid-Jso7>3.0.Co;2-O  0.326
1997 Helmlinger G, Netti PA, Lichtenbeld HC, Melder RJ, Jain RK. Solid stress inhibits the growth of multicellular tumor spheroids. Nature Biotechnology. 15: 778-83. PMID 9255794 DOI: 10.1038/Nbt0897-778  0.388
1997 Jeltsch M, Kaipainen A, Joukov V, Meng X, Lakso M, Rauvala H, Swartz M, Fukumura D, Jain RK, Alitalo K. Hyperplasia of lymphatic vessels in VEGF-C transgenic mice. Science (New York, N.Y.). 276: 1423-5. PMID 9162011 DOI: 10.1126/Science.276.5317.1423  0.434
1997 Baish JW, Netti PA, Jain RK. Transmural coupling of fluid flow in microcirculatory network and interstitium in tumors. Microvascular Research. 53: 128-41. PMID 9143544 DOI: 10.1006/Mvre.1996.2005  0.365
1997 Jain RK. The Eugene M. Landis Award Lecture 1996. Delivery of molecular and cellular medicine to solid tumors Microcirculation (New York, N.Y. : 1994). 4: 1-23. PMID 9110280 DOI: 10.3109/10739689709148314  0.411
1997 Helmlinger G, Yuan F, Dellian M, Jain RK. Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation. Nature Medicine. 3: 177-82. PMID 9018236 DOI: 10.1038/Nm0297-177  0.328
1997 Baish JW, Gazit Y, Berk DA, Nozue M, Baxter LT, Jain RK. Role of tumor vascular architecture in nutrient and drug delivery: an invasion percolation-based network model. Microvascular Research. 51: 327-46. PMID 8992232 DOI: 10.1006/Mvre.1996.0031  0.385
1997 Yuan F, Chen Y, Dellian M, Safabakhsh N, Ferrara N, Jain RK. Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody. Proceedings of the National Academy of Sciences of the United States of America. 93: 14765-70. PMID 8962129 DOI: 10.1073/Pnas.93.25.14765  0.382
1997 Netti PA, Baxter LT, Boucher Y, Skalak R, Jain RK. Macro- and Microscopic Fluid Transport in Living Tissues: Application to Solid Tumors Aiche Journal. 43: 818-833. DOI: 10.1002/Aic.690430327  0.301
1996 Nozue M, Lee I, Hartford A, Tanda S, Suit H, Jain R. pO(2) measurement in murine tumors by Eppendorf 'Histograph'. International Journal of Oncology. 9: 955-962. PMID 21541601 DOI: 10.3892/Ijo.9.5.955  0.332
1996 Lichtenbeld HC, Yuan F, Michel CC, Jain RK. Perfusion of single tumor microvessels: application to vascular permeability measurement. Microcirculation (New York, N.Y. : 1994). 3: 349-57. PMID 9086446 DOI: 10.3109/10739689609148307  0.374
1996 Jain RK, Koenig GC, Dellian M, Fukumura D, Munn LL, Melder RJ. Leukocyte-endothelial adhesion and angiogenesis in tumors. Cancer Metastasis Reviews. 15: 195-204. PMID 8842491 DOI: 10.1007/Bf00437472  0.378
1996 Jain RK. 1995 Whitaker lecture: Delivery of molecules, particles, and cells to solid tumors Annals of Biomedical Engineering. 24: 457-473. PMID 8841721 DOI: 10.1007/Bf02648108  0.411
1996 Netti PA, Roberge S, Boucher Y, Baxter LT, Jain RK. Effect of transvascular fluid exchange on pressure-flow relationship in tumors: a proposed mechanism for tumor blood flow heterogeneity. Microvascular Research. 52: 27-46. PMID 8812751 DOI: 10.1006/Mvre.1996.0041  0.334
1996 Melder RJ, Koenig GC, Witwer BP, Safabakhsh N, Munn LL, Jain RK. During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium. Nature Medicine. 2: 992-7. PMID 8782456 DOI: 10.1038/Nm0996-992  0.354
1996 Patan S, Munn LL, Jain RK. Intussusceptive microvascular growth in a human colon adenocarcinoma xenograft: a novel mechanism of tumor angiogenesis. Microvascular Research. 51: 260-72. PMID 8778579 DOI: 10.1006/Mvre.1996.0025  0.386
1996 Berk DA, Swartz MA, Leu AJ, Jain RK. Transport in lymphatic capillaries. II. Microscopic velocity measurement with fluorescence photobleaching. The American Journal of Physiology. 270: H330-7. PMID 8769769 DOI: 10.1152/Ajpheart.1996.270.1.H330  0.402
1996 Swartz MA, Berk DA, Jain RK. Transport in lymphatic capillaries. I. Macroscopic measurements using residence time distribution theory. The American Journal of Physiology. 270: H324-9. PMID 8769768 DOI: 10.1152/Ajpheart.1996.270.1.H324  0.415
1996 Nozue M, Lee I, Manning JM, Manning LR, Jain RK. Oxygenation in tumors by modified hemoglobins. Journal of Surgical Oncology. 62: 109-14. PMID 8649036 DOI: 10.1002/(Sici)1096-9098(199606)62:2<109::Aid-Jso6>3.0.Co;2-C  0.311
1996 Jain RK. Delivery of molecular medicine to solid tumors Science. 271: 1079-1080. PMID 8599082 DOI: 10.1126/Science.271.5252.1079  0.375
1996 Zlotecki RA, Baxter LT, Boucher Y, Jain RK. Pharmacologic modification of tumor blood flow and interstitial fluid pressure in a human tumor xenograft: network analysis and mechanistic interpretation. Microvascular Research. 50: 429-43. PMID 8583955 DOI: 10.1006/Mvre.1995.1069  0.362
1996 Melder RJ, Munn LL, Yamada S, Ohkubo C, Jain RK. Selectin- and integrin-mediated T-lymphocyte rolling and arrest on TNF-alpha-activated endothelium: augmentation by erythrocytes. Biophysical Journal. 69: 2131-8. PMID 8580357 DOI: 10.1016/S0006-3495(95)80087-1  0.303
1996 Boucher Y, Lee I, Jain RK. Lack of general correlation between interstitial fluid pressure and oxygen partial pressure in solid tumors. Microvascular Research. 50: 175-82. PMID 8538498 DOI: 10.1006/Mvre.1995.1051  0.373
1995 Lee I, Demhartner TJ, Boucher Y, Jain RK, Intaglietta M. Effect of hemodilution and resuscitation on tumor interstitial fluid pressure, blood flow, and oxygenation. Microvascular Research. 48: 1-12. PMID 7990716 DOI: 10.1006/Mvre.1994.1034  0.31
1995 Kristjansen PE, Roberge S, Lee I, Jain RK. Tissue-isolated human tumor xenografts in athymic nude mice. Microvascular Research. 48: 389-402. PMID 7731400 DOI: 10.1006/Mvre.1994.1063  0.384
1995 Melder RJ, Salehi HA, Jain RK. Interaction of activated natural killer cells with normal and tumor vessels in cranial windows in mice. Microvascular Research. 50: 35-44. PMID 7476578 DOI: 10.1006/Mvre.1995.1036  0.384
1995 Taghian A, Huang P, Allarn A, Perez L, Boucher Y, Lee I, Duffy M, Azinovic L, Jain R, Suit H. 1054 The correlation between fractionated TCD50 and different predictive radiobiologic parameters of nine human tumor xenografts into nude mice International Journal of Radiation Oncology*Biology*Physics. 32: 250. DOI: 10.1016/0360-3016(95)97879-6  0.312
1995 SWARTZ M, BERK D, LEU A, JAIN R. Macromolecular transport in the initial lymphatics: Characterization using RTD theory and FRAP Biorheology. 32: 351-351. DOI: 10.1016/0006-355X(95)92338-B  0.38
1995 NETTI P, BAXTER L, COUCHER Y, SKALAK R, JAIN R. A poroelastic model for interstitial pressure in tumors Biorheology. 32: 346-346. DOI: 10.1016/0006-355X(95)92330-D  0.327
1995 HELMLINGER G, NETTI P, LICHTENBELD H, MELDER R, JAIN R. Inhibition of tumor growth by solid stress Biorheology. 32: 345-346. DOI: 10.1016/0006-355X(95)92329-9  0.342
1995 GAZIT Y, PATAN S, BERK D, LEUNIG M, MUNN L, BAXTER L, JAIN R. S1.2. New insights into the structure of tumor vasculature: From fractal dimensions to intussusception Biorheology. 32: 112-112. DOI: 10.1016/0006-355X(95)91954-2  0.326
1994 Eskey CJ, Wolmark N, McDowell CL, Domach MM, Jain RK. Residence time distributions of various tracers in tumors: implications for drug delivery and blood flow measurement. Journal of the National Cancer Institute. 86: 293-9. PMID 8158684 DOI: 10.1093/Jnci/86.4.293  0.369
1994 Torres Filho IP, Leunig M, Yuan F, Intaglietta M, Jain RK. Noninvasive measurement of microvascular and interstitial oxygen profiles in a human tumor in SCID mice. Proceedings of the National Academy of Sciences of the United States of America. 91: 2081-5. PMID 8134352 DOI: 10.1073/Pnas.91.6.2081  0.367
1994 Jain RK. Barriers to drug delivery in solid tumors Scientific American. 271: 58-65. PMID 8066425 DOI: 10.1038/Scientificamerican0794-58  0.338
1994 Jain RK. INTERSTITIAL TRANSPORT IN TUMORS ROLE OF BINDING Journal of Immunotherapy. 16: 150. DOI: 10.1097/00002371-199408000-00018  0.313
1994 Jain RK. Transport Phenomena in Tumors Advances in Chemical Engineering. 19: 129-200. DOI: 10.1016/S0065-2377(08)60214-8  0.331
1993 Eskey CJ, Koretsky AP, Domach MM, Jain RK. Role of oxygen vs. glucose in energy metabolism in a mammary carcinoma perfused ex vivo: direct measurement by 31P NMR. Proceedings of the National Academy of Sciences of the United States of America. 90: 2646-50. PMID 8464871 DOI: 10.1073/Pnas.90.7.2646  0.344
1993 Yuan F, Leunig M, Berk DA, Jain RK. Microvascular permeability of albumin, vascular surface area, and vascular volume measured in human adenocarcinoma LS174T using dorsal chamber in SCID mice. Microvascular Research. 45: 269-89. PMID 8321142 DOI: 10.1006/Mvre.1993.1024  0.357
1993 Lee I, Gerweck LE, Boucher Y, Demhartner TJ, Mendello C, Jain RK. Improved physiological parameters in murine & human tumors by nicotinamide International Journal of Radiation Oncology*Biology*Physics. 27: 305. DOI: 10.1016/0360-3016(93)90921-H  0.333
1992 Less JR, Skalak TC, Sevick EM, Jain RK. Microvascular network architecture in a mammary carcinoma. Exs. 61: 74-80. PMID 1377578 DOI: 10.1007/978-3-0348-7001-6_13  0.371
1992 Zlotecki R, Boucher Y, Lee I, Jain R. Effect of angiotensin ii induced hypertension on tumor interstitial fluid pressure and tumor blood flow International Journal of Radiation Oncology*Biology*Physics. 24: 310. DOI: 10.1016/0360-3016(92)90442-K  0.339
1992 Lee I, Demhartner T, Boucher Y, Jain RK. Decrease in tumor interstitial fluid pressure by pentoxifylline International Journal of Radiation Oncology*Biology*Physics. 24: 307. DOI: 10.1016/0360-3016(92)90437-M  0.32
1992 Zanti C, Roh H, Boucher Y, King G, Kalnicki S, Buchsbaum R, Bloomer W, Jain R. Use of radiation on interstitial fluid pressure (IFP) and pO2 in human tumors International Journal of Radiation Oncology*Biology*Physics. 24: 306. DOI: 10.1016/0360-3016(92)90436-L  0.302
1992 Leunig M, Yuan F, Menger M, Goetz A, Messmer K, Jain R. A novel model to study microcirculation mediated mechanisms of radiotherapy in human tumor xenografts International Journal of Radiation Oncology*Biology*Physics. 24: 305-306. DOI: 10.1016/0360-3016(92)90435-K  0.361
1991 Baxter LT, Jain RK. Transport of fluid and macromolecules in tumors. II. Role of heterogeneous perfusion and lymphatics. Microvascular Research. 40: 246-63. PMID 2250603 DOI: 10.1016/0026-2862(90)90023-K  0.375
1991 Baxter LT, Jain RK. Transport of fluid and macromolecules in tumors. IV. A microscopic model of the perivascular distribution. Microvascular Research. 41: 252-72. PMID 2051960 DOI: 10.1016/0026-2862(91)90026-8  0.349
1991 Baxter LT, Jain RK. Transport of fluid and macromolecules in tumors. III. Role of binding and metabolism. Microvascular Research. 41: 5-23. PMID 2051954 DOI: 10.1016/0026-2862(91)90003-T  0.318
1991 Sasaki A, Melder RJ, Whiteside TL, Herberman RB, Jain RK. Preferential localization of human adherent lymphokine-activated killer cells in tumor microcirculation. Journal of the National Cancer Institute. 83: 433-437. PMID 1999850 DOI: 10.1093/Jnci/83.6.433  0.384
1991 Jain RK. Therapeutic implications of tumor physiology Current Opinion in Oncology. 3: 1105-1108. PMID 1843113 DOI: 10.1097/00001622-199112000-00020  0.396
1991 Jain RK. Haemodynamic and transport barriers to the treatment of solid tumours. International Journal of Radiation Biology. 60: 85-100. PMID 1678003 DOI: 10.1080/09553009114551621  0.322
1990 Jain RK. Vascular and interstitial barriers to delivery of therapeutic agents in tumors Cancer and Metastasis Review. 9: 253-266. PMID 2292138 DOI: 10.1007/Bf00046364  0.428
1990 Jain RK. Tumor physiology and antibody delivery Frontiers of Radiation Therapy and Oncology. 24: 32-46; discussion 64. PMID 2187763 DOI: 10.1159/000417767  0.341
1989 Jain RK. Delivery of novel therapeutic agents in tumors: Physiological barriers and strategies Journal of the National Cancer Institute. 81: 570-576. PMID 2649688 DOI: 10.1093/Jnci/81.8.570  0.358
1989 Baxter LT, Jain RK. Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection. Microvascular Research. 37: 77-104. PMID 2646512 DOI: 10.1016/0026-2862(89)90074-5  0.375
1988 Jain RK. Transvascular and interstitial transport in tumors Advances in Experimental Medicine and Biology. 242: 215-220. PMID 2469315 DOI: 10.1007/978-1-4684-8935-4_24  0.382
1987 Jain RK. Transport of molecules across tumor vasculature Cancer and Metastasis Review. 6: 559-593. PMID 3327633 DOI: 10.1007/Bf00047468  0.355
1986 Jain RK, Gerlowski LE. Extravascular transport in normal and tumor tissues. Critical Reviews in Oncology/Hematology. 5: 115-70. PMID 3521923 DOI: 10.1016/S1040-8428(86)80023-3  0.337
1986 Gerlowski LE, Jain RK. Microvascular permeability of normal and neoplastic tissues. Microvascular Research. 31: 288-305. PMID 2423854 DOI: 10.1016/0026-2862(86)90018-X  0.334
1985 Jain RK. Transport of macromolecules in tumor microcirculation Biotechnology Progress™. 1: 81-94. DOI: 10.1002/Btpr.5420010205  0.353
1984 Jain RK, Ward-Hartley K. Tumor Blood Flow-Characterization, Modifications, and Role in Hyperthermia Ieee Transactions On Sonics and Ultrasonics. 31: 504-525. DOI: 10.1109/T-Su.1984.31536  0.312
1983 Shah SA, Jain RK, Finney PL. Effects of hyperthermia and hyperglycemia on the metastases formation and on survival of rat bearing W256 carcinosarcoma. Advances in Experimental Medicine and Biology. 157: 23-42. PMID 7158522 DOI: 10.1007/978-1-4684-4388-2_4  0.338
1983 Shah SA, Jain RK, Finney PL. Enhanced metastasis formation by combined hyperthermia and hyperglycemia in rats bearing Walker 256 carcinosarcoma. Cancer Letters. 19: 317-23. PMID 6883314 DOI: 10.1016/0304-3835(83)90101-5  0.34
1983 Jain RK, Maldarelli C. STABILITY OF THIN VISCOELASTIC FILMS WITH APPLICATIONS TO BIOLOGICAL MEMBRANE DEFORMATION Annals of the New York Academy of Sciences. 404: 89-102. DOI: 10.1111/J.1749-6632.1983.Tb19435.X  0.695
1982 Gullino PM, Jain RK, Grantham FH. Temperature Gradients and Local Perfusion in a Mammary Carcinoma Journal of the National Cancer Institute. 68: 519-533. DOI: 10.1093/Jnci/68.3.519  0.336
1982 Maldarelli C, Jain RK. The linear, hydrodynamic stability of an interfacially perturbed, transversely isotropic, thin, planar viscoelastic film. II. Extension of the theory to the study of the onset of small-scale cell membrane motions Journal of Colloid and Interface Science. 90: 263-276. DOI: 10.1016/0021-9797(82)90418-0  0.701
1982 Maldarelli C, Jain RK. The linear, hydrodynamic stability of an interfacially perturbed, transversely isotropic, thin, planar viscoelastic film. I. General formulation and a derivation of the dispersion equation Journal of Colloid and Interface Science. 90: 233-262. DOI: 10.1016/0021-9797(82)90417-9  0.679
1981 Jain RK, Weissbrod JM, Wei J. Mass transport in tumors: characterization and applications to chemotherapy. Advances in Cancer Research. 33: 251-310. PMID 7006335 DOI: 10.1016/S0065-230X(08)60672-7  0.351
1980 Maldarelli C, Jain RK, Ivanov IB, Ruckenstein E. Stability of symmetric and unsymmetric thin liquid films to short and long wavelength perturbations Journal of Colloid and Interface Science. 78: 118-143. DOI: 10.1016/0021-9797(80)90501-9  0.724
1979 Jain RK, Grantham FH, Gullino PM. Blood Flow and Heat Transfer in Walker 256 Mammary Carcinoma Journal of the National Cancer Institute. 62: 927-933. DOI: 10.1093/Jnci/62.4.927  0.326
1976 Jain RK, Ruckenstein E. Stability of stagnant viscous films on a solid surface Journal of Colloid and Interface Science. 54: 108-116. DOI: 10.1016/0021-9797(76)90290-3  0.485
1974 Ruckenstein E, Jain RK. Spontaneous rupture of thin liquid films Journal of the Chemical Society, Faraday Transactions 2. 70: 132. DOI: 10.1039/F29747000132  0.491
Show low-probability matches.