Bruce A. Palfey - Publications

Affiliations: 
University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
Biochemistry

70 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Stull FW, Bernard SM, Sapra A, Smith JL, Zuiderweg ER, Palfey BA. Deprotonations in the Reaction of Flavin-Dependent Thymidylate Synthase. Biochemistry. PMID 27214228 DOI: 10.1021/acs.biochem.6b00510  1
2015 Teufel R, Stull F, Meehan MJ, Michaudel Q, Dorrestein PC, Palfey B, Moore BS. Biochemical Establishment and Characterization of EncM's Flavin-N5-oxide Cofactor. Journal of the American Chemical Society. 137: 8078-85. PMID 26067765 DOI: 10.1021/jacs.5b03983  1
2015 Maenpuen S, Amornwatcharapong W, Krasatong P, Sucharitakul J, Palfey BA, Yuthavong Y, Chitnumsub P, Leartsakulpanich U, Chaiyen P. Kinetic mechanism and the rate-limiting step of Plasmodium vivax serine hydroxymethyltransferase. The Journal of Biological Chemistry. 290: 8656-65. PMID 25678710 DOI: 10.1074/jbc.M114.612275  1
2014 Conrad JA, Ortiz-Maldonado M, Hoppe SW, Palfey BA. Detection of intermediates in the oxidative half-reaction of the FAD-dependent thymidylate synthase from Thermotoga maritima: carbon transfer without covalent pyrimidine activation. Biochemistry. 53: 5199-207. PMID 25068636 DOI: 10.1021/bi500648n  1
2014 Song Y, Zhang Y, Lee AR, Huang WH, Chen B, Palfey B, Shaw J. Comparison of two molecular scaffolds, 5-methylisoxazole-3-carboxamide and 5-methylisoxazole-4-carboxamide. Current Pharmaceutical Design. 20: 146-52. PMID 23944378 DOI: 10.2174/13816128113199990584  1
2013 Teufel R, Miyanaga A, Michaudel Q, Stull F, Louie G, Noel JP, Baran PS, Palfey B, Moore BS. Flavin-mediated dual oxidation controls an enzymatic Favorskii-type rearrangement. Nature. 503: 552-6. PMID 24162851 DOI: 10.1038/nature12643  1
2013 McDonald CA, Liu YY, Palfey BA. Actin stimulates reduction of the MICAL-2 monooxygenase domain. Biochemistry. 52: 6076-84. PMID 23927065 DOI: 10.1021/bi4008462  1
2013 Prongjit M, Sucharitakul J, Palfey BA, Chaiyen P. Oxidation mode of pyranose 2-oxidase is controlled by pH. Biochemistry. 52: 1437-45. PMID 23356577 DOI: 10.1021/bi301442x  1
2013 Palfey BA. Flavoenzymes in pyrimidine metabolism Handbook of Flavoproteins: Complex Flavoproteins, Dehydrogenases and Physical Methods. 2: 203-224. DOI: 10.1515/9783110298345.203  1
2012 Mishanina TV, Koehn EM, Conrad JA, Palfey BA, Lesley SA, Kohen A. Trapping of an intermediate in the reaction catalyzed by flavin-dependent thymidylate synthase. Journal of the American Chemical Society. 134: 4442-8. PMID 22295882 DOI: 10.1021/ja2120822  1
2011 McDonald CA, Fagan RL, Collard F, Monnier VM, Palfey BA. Oxygen reactivity in flavoenzymes: context matters. Journal of the American Chemical Society. 133: 16809-11. PMID 21958058 DOI: 10.1021/ja2081873  1
2011 Collard F, Fagan RL, Zhang J, Nemet I, Palfey BA, Monnier VM. The cation-π interaction between Lys53 and the flavin of fructosamine oxidase (FAOX-II) is critical for activity. Biochemistry. 50: 7977-86. PMID 21755947 DOI: 10.1021/bi1020666  1
2011 McDonald CA, Palfey BA. Substrate binding and reactivity are not linked: grafting a proton-transfer network into a Class 1A dihydroorotate dehydrogenase. Biochemistry. 50: 2714-6. PMID 21401078 DOI: 10.1021/bi200258y  1
2010 Purcell EB, McDonald CA, Palfey BA, Crosson S. An analysis of the solution structure and signaling mechanism of LovK, a sensor histidine kinase integrating light and redox signals. Biochemistry. 49: 6761-70. PMID 20593779 DOI: 10.1021/bi1006404  1
2010 Palfey BA, McDonald CA. Control of catalysis in flavin-dependent monooxygenases. Archives of Biochemistry and Biophysics. 493: 26-36. PMID 19944667 DOI: 10.1016/j.abb.2009.11.028  1
2010 Fagan RL, Palfey BA. Flavin-dependent enzymes Comprehensive Natural Products Ii: Chemistry and Biology. 7: 37-113.  1
2009 Kow RL, Whicher JR, McDonald CA, Palfey BA, Fagan RL. Disruption of the proton relay network in the class 2 dihydroorotate dehydrogenase from Escherichia coli. Biochemistry. 48: 9801-9. PMID 19694481 DOI: 10.1021/bi901024m  1
2009 Binter A, Staunig N, Jelesarov I, Lohner K, Palfey BA, Deller S, Gruber K, Macheroux P. A single intersubunit salt bridge affects oligomerization and catalytic activity in a bacterial quinone reductase. The Febs Journal. 276: 5263-74. PMID 19682074 DOI: 10.1111/j.1742-4658.2009.07222.x  1
2009 Sollner S, Deller S, Macheroux P, Palfey BA. Mechanism of flavin reduction and oxidation in the redox-sensing quinone reductase Lot6p from Saccharomyces cerevisiae. Biochemistry. 48: 8636-43. PMID 19618916 DOI: 10.1021/bi900734a  1
2009 Fagan RL, Palfey BA. Roles in binding and chemistry for conserved active site residues in the class 2 dihydroorotate dehydrogenase from Escherichia coli. Biochemistry. 48: 7169-78. PMID 19530672 DOI: 10.1021/bi900370s  1
2009 Koehn EM, Fleischmann T, Conrad JA, Palfey BA, Lesley SA, Mathews II, Kohen A. An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene Nature. 458: 919-923. PMID 19370033 DOI: 10.1038/nature07973  1
2009 Rider LW, Ottosen MB, Gattis SG, Palfey BA. Mechanism of dihydrouridine synthase 2 from yeast and the importance of modifications for efficient tRNA reduction. The Journal of Biological Chemistry. 284: 10324-33. PMID 19139092 DOI: 10.1074/jbc.M806137200  1
2009 Sollner S, Schober M, Wagner A, Prem A, Lorkova L, Palfey BA, Groll M, Macheroux P. Quinone reductase acts as a redox switch of the 20S yeast proteasome. Embo Reports. 10: 65-70. PMID 19029946 DOI: 10.1038/embor.2008.218  1
2008 Padovani D, Labunska T, Palfey BA, Ballou DP, Banerjee R. Adenosyltransferase tailors and delivers coenzyme B12 Nature Chemical Biology. 4: 194-196. PMID 18264093 DOI: 10.1038/nchembio.67  1
2007 Wolfe AE, Thymark M, Gattis SG, Fagan RL, Hu YC, Johansson E, Arent S, Larsen S, Palfey BA. Interaction of benzoate pyrimidine analogues with class 1A dihydroorotate dehydrogenase from Lactococcus lactis. Biochemistry. 46: 5741-53. PMID 17444658 DOI: 10.1021/bi7001554  1
2007 Levin I, Mevarech M, Palfey BA. Characterization of a novel bifunctional dihydropteroate synthase/dihydropteroate reductase enzyme from Helicobacter pylori. Journal of Bacteriology. 189: 4062-9. PMID 17416665 DOI: 10.1128/JB.01878-06  1
2007 Fagan RL, Jensen KF, Björnberg O, Palfey BA. Mechanism of flavin reduction in the class 1A dihydroorotate dehydrogenase from Lactococcus lactis. Biochemistry. 46: 4028-36. PMID 17341096 DOI: 10.1021/bi602460n  1
2007 Sollner S, Nebauer R, Ehammer H, Prem A, Deller S, Palfey BA, Daum G, Macheroux P. Lot6p from Saccharomyces cerevisiae is a FMN-dependent reductase with a potential role in quinone detoxification. The Febs Journal. 274: 1328-39. PMID 17298444 DOI: 10.1111/j.1742-4658.2007.05682.x  1
2006 Bucholtz TJ, Palfey B, Mapp AK, Glick GD. Graduate education chemical biology at the University of Michigan. Acs Chemical Biology. 1: 487-8. PMID 17168532 DOI: 10.1021/cb600315r  1
2006 Fagan RL, Nelson MN, Pagano PM, Palfey BA. Mechanism of flavin reduction in class 2 dihydroorotate dehydrogenases. Biochemistry. 45: 14926-32. PMID 17154530 DOI: 10.1021/bi060919g  1
2006 Palfey BA, Fagan RL. Analysis of the kinetic isotope effects on initial rates in transient kinetics. Biochemistry. 45: 13631-40. PMID 17087517 DOI: 10.1021/bi061214h  1
2006 Shi J, Dertouzos J, Gafni A, Steel D, Palfey BA. Single-molecule kinetics reveals signatures of half-sites reactivity in dihydroorotate dehydrogenase A catalysis. Proceedings of the National Academy of Sciences of the United States of America. 103: 5775-80. PMID 16585513 DOI: 10.1073/pnas.0510482103  1
2006 Fisher HF, Palfey BA, Maniscalco SJ, Indyk L. Relationship between the time-dependence of a transient-state kinetic isotope effect and the location of complexes in a reaction sequence. The Journal of Physical Chemistry. A. 110: 4465-72. PMID 16571051 DOI: 10.1021/jp057254x  1
2005 Brender JR, Dertouzos J, Ballou DP, Massey V, Palfey BA, Entsch B, Steel DG, Gafni A. Conformational dynamics of the isoalloxazine in substrate-free p-hydroxybenzoate hydroxylase: single-molecule studies. Journal of the American Chemical Society. 127: 18171-8. PMID 16366570 DOI: 10.1021/ja055171o  1
2005 Frederick KK, Palfey BA. Kinetics of proton-linked flavin conformational changes in p-hydroxybenzoate hydroxylase. Biochemistry. 44: 13304-14. PMID 16201756 DOI: 10.1021/bi051119t  1
2005 Gattis SG, Palfey BA. Direct observation of the participation of flavin in product formation by thyX-encoded thymidylate synthase. Journal of the American Chemical Society. 127: 832-3. PMID 15656610 DOI: 10.1021/ja0432214  1
2004 Shi J, Palfey BA, Dertouzos J, Jensen KF, Gafni A, Steel D. Multiple states of the Tyr318Leu mutant of dihydroorotate dehydrogenase revealed by single-molecule kinetics. Journal of the American Chemical Society. 126: 6914-22. PMID 15174861 DOI: 10.1021/ja038902y  1
2004 Zheng Y, Carey PR, Palfey BA. Raman spectrum of fully reduced flavin Journal of Raman Spectroscopy. 35: 521-524. DOI: 10.1002/jrs.1218  1
2003 Palfey BA, Murthy YV, Massey V. Altered balance of half-reactions in p-hydroxybenzoate hydroxylase caused by substituting the 2'-carbon of FAD with fluorine. The Journal of Biological Chemistry. 278: 22210-6. PMID 12684497 DOI: 10.1074/jbc.M301830200  1
2003 Argyrou A, Sun G, Palfey BA, Blanchard JS. Catalysis of diaphorase reactions by Mycobacterium tuberculosis lipoamide dehydrogenase occurs at the EH4 level. Biochemistry. 42: 2218-28. PMID 12590611 DOI: 10.1021/bi020654f  1
2002 Argyrou A, Blanchard JS, Palfey BA. The lipoamide dehydrogenase from Mycobacterium tuberculosis permits the direct observation of flavin intermediates in catalysis. Biochemistry. 41: 14580-90. PMID 12463758 DOI: 10.1021/bi020376k  1
2002 Ottosen MB, Björnberg O, Nørager S, Larsen S, Palfey BA, Jensen KF. The dimeric dihydroorotate dehydrogenase A from Lactococcus lactis dissociates reversibly into inactive monomers. Protein Science : a Publication of the Protein Society. 11: 2575-83. PMID 12381841 DOI: 10.1110/ps.0220302  1
2002 Palfey BA, Basu R, Frederick KK, Entsch B, Ballou DP. Role of protein flexibility in the catalytic cycle of p-hydroxybenzoate hydroxylase elucidated by the Pro293Ser mutant Biochemistry. 41: 8438-8446. PMID 12081493 DOI: 10.1021/bi012073g  1
2001 Wu X, Palfey BA, Mossine VV, Monnier VM. Kinetic studies, mechanism, and substrate specificity of amadoriase I from Aspergillus sp. Biochemistry. 40: 12886-95. PMID 11669625 DOI: 10.1021/bi011244e  1
2001 Palfey BA, Björnberg O, Jensen KF. Specific inhibition of a family 1A dihydroorotate dehydrogenase by benzoate pyrimidine analogues. Journal of Medicinal Chemistry. 44: 2861-4. PMID 11520193 DOI: 10.1021/jm015535x  1
2001 Björnberg O, Jordan DB, Palfey BA, Jensen KF. Dihydrooxonate is a substrate of dihydroorotate dehydrogenase (DHOD) providing evidence for involvement of cysteine and serine residues in base catalysis. Archives of Biochemistry and Biophysics. 391: 286-94. PMID 11437361 DOI: 10.1006/abbi.2001.2409  1
2001 Frederick KK, Ballou DP, Palfey BA. Protein dynamics control proton transfers to the substrate on the His72Asn mutant of p-hydroxybenzoate hydroxylase Biochemistry. 40: 3891-3899. PMID 11300768 DOI: 10.1021/bi001851m  1
2001 Palfey BA, Björnberg O, Jensen KF. Insight into the chemistry of flavin reduction and oxidation in Escherichia coli dihydroorotate dehydrogenase obtained by rapid reaction studies. Biochemistry. 40: 4381-90. PMID 11284694 DOI: 10.1021/bi0025666  1
2001 Altose MD, Zheng Y, Dong J, Palfey BA, Carey PR. Comparing protein-ligand interactions in solution and single crystals by Raman spectroscopy. Proceedings of the National Academy of Sciences of the United States of America. 98: 3006-11. PMID 11248022 DOI: 10.1073/pnas.061029598  1
2001 Zheng Y, Massey V, Schaller A, Palfey BA, Carey PR. Comparison of resonance Raman spectra of flavin-3,4-dihydroxybenzoate charge-transfer complexes in three flavoenzymes Journal of Raman Spectroscopy. 32: 579-586. DOI: 10.1002/jrs.738  1
2000 Wade PA, Murray JK, Shah-Patel S, Palfey BA, Carroll PJ. Tandem nitroaldol-dehydration reactions employing the dianion of phenylsulfonylnitromethane(1) The Journal of Organic Chemistry. 65: 7723-30. PMID 11073572 DOI: 10.1021/jo0000170  1
2000 Ridder L, Palfey BA, Vervoort J, Rietjens IMCM. Modelling flavin and substrate substituent effects on the activation barrier and rate of oxygen transfer by p-hydroxybenzoate hydroxylase Febs Letters. 478: 197-201. PMID 10922496 DOI: 10.1016/S0014-5793(00)01844-5  1
2000 Yorita K, Misaki H, Palfey BA, Massey V. On the interpretation of quantitative structure-function activity relationship data for lactate oxidase. Proceedings of the National Academy of Sciences of the United States of America. 97: 2480-5. PMID 10706608 DOI: 10.1073/pnas.040559797  1
1999 Zheng Y, Dong J, Palfey BA, Carey PR. Using raman spectroscopy to monitor the solvent-exposed and 'buried' forms of flavin in p-hydroxybenzoate hydroxylase Biochemistry. 38: 16727-16732. PMID 10606503 DOI: 10.1021/bi9918893  1
1999 Moran GR, Entsch B, Palfey BA, Ballou DP. Mechanistic insights into p-hydroxybenzoate hydroxylase from studies of the mutant Ser212Ala. Biochemistry. 38: 6292-9. PMID 10320359 DOI: 10.1021/bi990021+  1
1999 Palfey BA, Moran GR, Entsch B, Ballou DP, Massey V. Substrate recognition by "password" in p-hydroxybenzoate hydroxylase. Biochemistry. 38: 1153-8. PMID 9930974 DOI: 10.1021/bi9826613  1
1999 Zheng Y, Dong J, Palfey BA, Carey PR. Using Raman spectroscopy to monitor the solvent-exposed and "buried" forms of flavin in p-hydroxybenzoate hydroxylase Biochemistry. 38.  1
1999 Palfey BA, Moran GR, Entsch B, Ballou DP, Massey V. Substrate recognition by "password" in p-hydroxybenzoate hydroxylase Biochemistry. 38: x-1158.  1
1997 Palfey BA, Ballou DP, Massey V. Flavin conformational changes in the catalytic cycle of p-hydroxybenzoate hydroxylase substituted with 6-azido- and 6-aminoflavin adenine dinucleotide. Biochemistry. 36: 15713-23. PMID 9398300 DOI: 10.1021/bi971427u  1
1997 Clarkson J, Palfey BA, Carey PR. Probing the chemistries of the substrate and flavin ring system of p- hydroxybenzoate hydroxylase by Raman difference spectroscopy Biochemistry. 36: 12560-12566. PMID 9376361 DOI: 10.1021/bi9715270  1
1997 Yorita K, Janko K, Aki K, Ghisla S, Palfey BA, Massey V. On the reaction mechanism of L-lactate oxidase: quantitative structure-activity analysis of the reaction with para-substituted L-mandelates. Proceedings of the National Academy of Sciences of the United States of America. 94: 9590-5. PMID 9275167 DOI: 10.1073/pnas.94.18.9590  1
1997 Moran GR, Entsch B, Palfey BA, Ballou DP. Electrostatic effects on substrate activation in para-hydroxybenzoate hydroxylase: studies of the mutant lysine 297 methionine. Biochemistry. 36: 7548-56. PMID 9200706 DOI: 10.1021/bi9706327  1
1997 Palfey BA, Moran G, Entsch B, Ballou DP, Massey V. Flavin movement during the reductive half-reaction of p-hydroxybenzoate hydroxylase Faseb Journal. 11: A853.  1
1996 Moran GR, Entsch B, Palfey BA, Ballou DP. Evidence for flavin movement in the function of p-hydroxybenzoate hydroxylase from studies of the mutant Arg220Lys. Biochemistry. 35: 9278-85. PMID 8703933 DOI: 10.1021/bi960360s  1
1995 Zhang ZY, Palfey BA, Wu L, Zhao Y. Catalytic function of the conserved hydroxyl group in the protein tyrosine phosphatase signature motif Biochemistry. 34: 16389-16396. PMID 8845365 DOI: 10.1021/bi00050a020  1
1994 Lah MS, Palfey BA, Schreuder HA, Ludwig ML. Crystal structures of mutant Pseudomonas aeruginosa p-hydroxybenzoate hydroxylases: the Tyr201Phe, Tyr385Phe, and Asn300Asp variants. Biochemistry. 33: 1555-64. PMID 8312276  1
1994 Palfey BA, Entsch B, Ballou DP, Massey V. Changes in the catalytic properties of p-hydroxybenzoate hydroxylase caused by the mutation Asn300Asp. Biochemistry. 33: 1545-54. PMID 8312275  1
1994 Gatti DL, Palfey BA, Lah MS, Entsch B, Massey V, Ballou DP, Ludwig ML. The mobile flavin of 4-OH benzoate hydroxylase. Science (New York, N.Y.). 266: 110-4. PMID 7939628  1
1991 Entsch B, Palfey BA, Ballou DP, Massey V. Catalytic function of tyrosine residues in para-hydroxybenzoate hydroxylase as determined by the study of site-directed mutants. The Journal of Biological Chemistry. 266: 17341-9. PMID 1910043  1
1990 Wade PA, Bereznak JF, Palfey BA, Carroll PJ, Dailey WP, Sivasubramanian S. Diastereofacial selectivity studies on 3-alkenyl-4,5-diphenyl-4,5-dihydroisoxazoles Journal of Organic Chemistry. 55: 3045-3051.  1
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