Michael B. Sporn - Publications

Affiliations: 
Pharmacology and Toxicology Dartmouth College, Hanover, NH, United States 
Area:
Molecular Biology, Biochemistry

375 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Suh N, Paul S, Lee HJ, Yoon T, Shah N, Son AI, Reddi AH, Medici D, Sporn MB. Retraction notice to "Synthetic triterpenoids, CDDO-Imidazolide and CDDO-Ethyl amide, induce chondrogenesis" [Osteoarthr Cartil 20 (2012) 446-450]. Osteoarthritis and Cartilage. 28: 865. PMID 32471658 DOI: 10.1016/j.joca.2020.05.005  0.44
2019 Leal AS, Zydeck K, Carapellucci S, Reich LA, Zhang D, Moerland JA, Sporn MB, Liby KT. Retinoid X receptor agonist LG100268 modulates the immune microenvironment in preclinical breast cancer models. Npj Breast Cancer. 5: 39. PMID 31700995 DOI: 10.1038/s41523-019-0135-5  0.64
2019 Zhang D, Leal AS, Carapellucci S, Shahani PH, Bhogal JS, Ibrahim S, Raban S, Jurutka PW, Marshall PA, Sporn MB, Wagner CE, Liby KT. Testing Novel Pyrimidinyl Rexinoids: A New Paradigm for Evaluating Rexinoids for Cancer Prevention. Cancer Prevention Research (Philadelphia, Pa.). PMID 30760500 DOI: 10.1158/1940-6207.CAPR-18-0317  0.64
2017 Zhang D, Leal AS, Carapellucci S, Zydeck K, Sporn MB, Liby KT. Chemoprevention of preclinical breast and lung cancer with the bromodomain inhibitor I-BET 762. Cancer Prevention Research (Philadelphia, Pa.). PMID 29246957 DOI: 10.1158/1940-6207.CAPR-17-0264  0.64
2017 Crowley VM, Ayi K, Lu Z, Liby KT, Sporn M, Kain KC. Synthetic oleanane triterpenoids enhance blood brain barrier integrity and improve survival in experimental cerebral malaria. Malaria Journal. 16: 463. PMID 29137631 DOI: 10.1186/s12936-017-2109-0  0.64
2017 Fu L, Lin QX, Onyango EO, Liby KT, Sporn MB, Gribble GW. Design, synthesis, and biological activity of second-generation synthetic oleanane triterpenoids. Organic & Biomolecular Chemistry. PMID 28678272 DOI: 10.1039/c7ob01420a  0.64
2017 Leal AS, Williams CR, Royce DB, Pioli PA, Sporn MB, Liby KT. Bromodomain inhibitors, JQ1 and I-BET 762, as potential therapies for pancreatic cancer. Cancer Letters. PMID 28254412 DOI: 10.1016/j.canlet.2017.02.021  0.64
2016 Leal AS, Sporn MB, Pioli PA, Liby KT. The triterpenoid CDDO-Imidazolide reduces immune cell infiltration and cytokine secretion in the KrasG12D;Pdx1-Cre mouse (KC) mouse model of pancreatic cancer. Carcinogenesis. PMID 27659181 DOI: 10.1093/carcin/bgw099  0.64
2016 Liby KT, Sporn MB. Rexinoids for prevention and treatment of cancer: opportunities and challenges. Current Topics in Medicinal Chemistry. PMID 27320330  0.64
2016 Sporn MB. Commentary on Eagle and Foley: "Cytotoxicity in Human Cell Cultures". Cancer Research. 76: 989-90. PMID 26933164 DOI: 10.1158/0008-5472.CAN-16-0152  0.64
2015 Cao M, Royce DB, Risingsong R, Williams CR, Sporn MB, Liby KT. The rexinoids LG100268 and LG101506 inhibit inflammation and suppress lung carcinogenesis in A/J mice. Cancer Prevention Research (Philadelphia, Pa.). PMID 26554632 DOI: 10.1158/1940-6207.CAPR-15-0325  0.64
2015 Cao M, Onyango EO, Williams CR, Royce DB, Gribble GW, Sporn MB, Liby KT. Novel Synthetic Pyridyl Analogues of CDDO-Imidazolide Are Useful New Tools in Cancer Prevention. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. PMID 26238177 DOI: 10.1016/j.phrs.2015.07.024  0.64
2015 To C, Ringelberg CS, Royce DB, Williams CR, Risingsong R, Sporn MB, Liby KT. Dimethyl fumarate and the oleanane triterpenoids, CDDO-imidazolide and CDDO-methyl ester, both activate the Nrf2 pathway but have opposite effects in the A/J model of lung carcinogenesis. Carcinogenesis. PMID 25939751 DOI: 10.1093/carcin/bgv061  0.64
2015 Xu Z, Cho H, Hartsock MJ, Mitchell KL, Gong J, Wu L, Wei Y, Wang S, Thimmulappa RK, Sporn MB, Biswal S, Welsbie DS, Duh EJ. Neuroprotective role of Nrf2 for retinal ganglion cells in ischemia-reperfusion. Journal of Neurochemistry. 133: 233-41. PMID 25683606 DOI: 10.1111/jnc.13064  0.64
2014 To C, Sporn MB, Liby KT. PARP inhibitors for chemoprevention--reply. Cancer Prevention Research (Philadelphia, Pa.). 7: 1172. PMID 25368012 DOI: 10.1158/1940-6207.CAPR-14-0264  0.64
2014 So JY, Lin JJ, Wahler J, Liby KT, Sporn MB, Suh N. A synthetic triterpenoid CDDO-Im inhibits tumorsphere formation by regulating stem cell signaling pathways in triple-negative breast cancer. Plos One. 9: e107616. PMID 25229616 DOI: 10.1371/journal.pone.0107616  0.64
2014 Fu L, Lin QX, Liby KT, Sporn MB, Gribble GW. An efficient synthesis of methyl 2-cyano-3,12-dioxoursol-1,9-dien-28-oate (CDDU-methyl ester): analogues, biological activities, and comparison with oleanolic acid derivatives. Organic & Biomolecular Chemistry. 12: 5192-200. PMID 24915424 DOI: 10.1039/c4ob00679h  0.64
2014 Choi SH, Kim BG, Robinson J, Fink S, Yan M, Sporn MB, Markowitz SD, Letterio JJ. Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis Journal of Clinical Investigation. 124: 2472-2482. PMID 24837432 DOI: 10.1172/JCI69672  0.64
2014 To C, Kim EH, Royce DB, Williams CR, Collins RM, Risingsong R, Sporn MB, Liby KT. The PARP inhibitors, veliparib and olaparib, are effective chemopreventive agents for delaying mammary tumor development in BRCA1-deficient mice. Cancer Prevention Research (Philadelphia, Pa.). 7: 698-707. PMID 24817481 DOI: 10.1158/1940-6207.CAPR-14-0047  0.64
2014 Johnson NM, Egner PA, Baxter VK, Sporn MB, Wible RS, Sutter TR, Groopman JD, Kensler TW, Roebuck BD. Complete protection against aflatoxin B(1)-induced liver cancer with a triterpenoid: DNA adduct dosimetry, molecular signature, and genotoxicity threshold. Cancer Prevention Research (Philadelphia, Pa.). 7: 658-65. PMID 24662598 DOI: 10.1158/1940-6207.CAPR-13-0430  0.64
2014 Kehrl JH, Wakefield LM, Roberts AB, Jakowlew S, Alvarez-Mon M, Derynck R, Sporn MB, Fauci AS. Pillars Article: production of transforming growth factor β by human T lymphocytes and its potential role in the regulation of T cell growth. J Exp Med. 1986. 163: 1037-1050. Journal of Immunology (Baltimore, Md. : 1950). 192: 2939-52. PMID 24659787  0.64
2014 Onyango EO, Fu L, Cao M, Liby KT, Sporn MB, Gribble GW. Synthesis and biological evaluation of amino acid methyl ester conjugates of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid against the production of nitric oxide (NO) Bioorganic and Medicinal Chemistry Letters. 24: 532-534. PMID 24388806 DOI: 10.1016/j.bmcl.2013.12.034  0.64
2014 Liu M, Reddy NM, Higbee EM, Potteti HR, Noel S, Racusen L, Kensler TW, Sporn MB, Reddy SP, Rabb H. The Nrf2 triterpenoid activator, CDDO-imidazolide, protects kidneys from ischemia-reperfusion injury in mice. Kidney International. 85: 134-41. PMID 24088953 DOI: 10.1038/ki.2013.357  0.64
2013 So JY, Wahler JE, Yoon T, Smolarek AK, Lin Y, Shih WJ, Maehr H, Uskokovic M, Liby KT, Sporn MB, Suh N. Oral administration of a gemini vitamin D analog, a synthetic triterpenoid and the combination prevents mammary tumorigenesis driven by ErbB2 overexpression. Cancer Prevention Research (Philadelphia, Pa.). 6: 959-70. PMID 23856074 DOI: 10.1158/1940-6207.CAPR-13-0087  0.64
2013 Sporn MB, Liby KT. Is lycopene an effective agent for preventing prostate cancer? Cancer Prevention Research (Philadelphia, Pa.). 6: 384-6. PMID 23483003 DOI: 10.1158/1940-6207.CAPR-13-0026  0.64
2013 Davidson BA, Vethanayagam RR, Grimm MJ, Mullan BA, Raghavendran K, Blackwell TS, Freeman ML, Ayyasamy V, Singh KK, Sporn MB, Itagaki K, Hauser CJ, Knight PR, Segal BH. NADPH oxidase and Nrf2 regulate gastric aspiration-induced inflammation and acute lung injury. Journal of Immunology (Baltimore, Md. : 1950). 190: 1714-24. PMID 23296708 DOI: 10.4049/jimmunol.1202410  0.64
2013 Balboni AL, Hutchinson JA, DeCastro AJ, Cherukuri P, Liby K, Sporn MB, Schwartz GN, Wells WA, Sempere LF, Yu PB, DiRenzo J. ΔNp63α-mediated activation of bone morphogenetic protein signaling governs stem cell activity and plasticity in normal and malignant mammary epithelial cells. Cancer Research. 73: 1020-30. PMID 23243027 DOI: 10.1158/0008-5472.CAN-12-2862  0.64
2013 Tran K, Risingsong R, Royce DB, Williams CR, Sporn MB, Pioli PA, Gediya LK, Njar VC, Liby KT. The combination of the histone deacetylase inhibitor vorinostat and synthetic triterpenoids reduces tumorigenesis in mouse models of cancer. Carcinogenesis. 34: 199-210. PMID 23042302 DOI: 10.1093/carcin/bgs319  0.64
2013 Kaidery NA, Banerjee R, Yang L, Smirnova NA, Hushpulian DM, Liby KT, Williams CR, Yamamoto M, Kensler TW, Ratan RR, Sporn MB, Beal MF, Gazaryan IG, Thomas B. Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinson's disease. Antioxidants & Redox Signaling. 18: 139-57. PMID 22746536 DOI: 10.1089/ars.2011.4491  0.64
2013 Sporn MB, Liby KT. A mini-review of chemoprevention of cancer - past, present, and future Progress in Chemistry. 25: 1421-1428.  0.64
2012 Liby KT, Sporn MB. Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease. Pharmacological Reviews. 64: 972-1003. PMID 22966038 DOI: 10.1124/pr.111.004846  0.64
2012 Sporn MB, Liby KT. NRF2 and cancer: the good, the bad and the importance of context. Nature Reviews. Cancer. 12: 564-71. PMID 22810811 DOI: 10.1038/nrc3278  0.64
2012 Zhang F, Wang S, Zhang M, Weng Z, Li P, Gan Y, Zhang L, Cao G, Gao Y, Leak RK, Sporn MB, Chen J. Pharmacological induction of heme oxygenase-1 by a triterpenoid protects neurons against ischemic injury. Stroke; a Journal of Cerebral Circulation. 43: 1390-7. PMID 22461332 DOI: 10.1161/STROKEAHA.111.647420  0.56
2012 Tran K, Risingsong R, Royce D, Williams CR, Sporn MB, Liby K. The synthetic triterpenoid CDDO-methyl ester delays estrogen receptor-negative mammary carcinogenesis in polyoma middle T mice. Cancer Prevention Research (Philadelphia, Pa.). 5: 726-34. PMID 22401982 DOI: 10.1158/1940-6207.CAPR-11-0404  0.64
2012 Suh N, Paul S, Lee HJ, Yoon T, Shah N, Son AI, Reddi AH, Medici D, Sporn MB. Synthetic triterpenoids, CDDO-Imidazolide and CDDO-Ethyl amide, induce chondrogenesis. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. 20: 446-50. PMID 22343171 DOI: 10.1016/j.joca.2012.01.018  0.64
2012 Kim EH, Deng C, Sporn MB, Royce DB, Risingsong R, Williams CR, Liby KT. CDDO-methyl ester delays breast cancer development in BRCA1-mutated mice. Cancer Prevention Research (Philadelphia, Pa.). 5: 89-97. PMID 21933912 DOI: 10.1158/1940-6207.CAPR-11-0359  0.64
2011 Pareek TK, Belkadi A, Kesavapany S, Zaremba A, Loh SL, Bai L, Cohen ML, Meyer C, Liby KT, Miller RH, Sporn MB, Letterio JJ. Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis. Scientific Reports. 1: 201. PMID 22355716 DOI: 10.1038/srep00201  0.64
2011 Yore MM, Kettenbach AN, Sporn MB, Gerber SA, Liby KT. Proteomic analysis shows synthetic oleanane triterpenoid binds to mTOR. Plos One. 6: e22862. PMID 21818401 DOI: 10.1371/journal.pone.0022862  0.64
2011 Wei Y, Gong J, Yoshida T, Eberhart CG, Xu Z, Kombairaju P, Sporn MB, Handa JT, Duh EJ. Nrf2 has a protective role against neuronal and capillary degeneration in retinal ischemia-reperfusion injury. Free Radical Biology & Medicine. 51: 216-24. PMID 21545836 DOI: 10.1016/j.freeradbiomed.2011.04.026  0.4
2011 Neymotin A, Calingasan NY, Wille E, Naseri N, Petri S, Damiano M, Liby KT, Risingsong R, Sporn M, Beal MF, Kiaei M. Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis. Free Radical Biology & Medicine. 51: 88-96. PMID 21457778 DOI: 10.1016/j.freeradbiomed.2011.03.027  0.64
2011 Sporn MB. Perspective: The big C - for Chemoprevention. Nature. 471: S10-1. PMID 21430710 DOI: 10.1038/471S10a  0.64
2011 Kim EH, Deng CX, Sporn MB, Liby KT. CDDO-imidazolide induces DNA damage, G2/M arrest and apoptosis in BRCA1-mutated breast cancer cells. Cancer Prevention Research (Philadelphia, Pa.). 4: 425-34. PMID 21372041 DOI: 10.1158/1940-6207.CAPR-10-0153  0.64
2011 Sporn MB, Liby KT, Yore MM, Fu L, Lopchuk JM, Gribble GW. New synthetic triterpenoids: Potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress Journal of Natural Products. 74: 537-545. PMID 21309592 DOI: 10.1021/np100826q  0.64
2011 Townson JL, Macdonald IC, Liby KT, Mackenzie L, Dales DW, Hedley BD, Foster PJ, Sporn MB, Chambers AF. The synthetic triterpenoid CDDO-Imidazolide suppresses experimental liver metastasis. Clinical & Experimental Metastasis. 28: 309-17. PMID 21234655 DOI: 10.1007/s10585-011-9374-z  0.64
2010 Liby KT, Royce DB, Risingsong R, Williams CR, Maitra A, Hruban RH, Sporn MB. Synthetic triterpenoids prolong survival in a transgenic mouse model of pancreatic cancer. Cancer Prevention Research (Philadelphia, Pa.). 3: 1427-34. PMID 20959520 DOI: 10.1158/1940-6207.CAPR-10-0197  0.64
2010 Stack C, Ho D, Wille E, Calingasan NY, Williams C, Liby K, Sporn M, Dumont M, Beal MF. Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's disease. Free Radical Biology & Medicine. 49: 147-58. PMID 20338236 DOI: 10.1016/j.freeradbiomed.2010.03.017  0.64
2010 Segal BH, Han W, Bushey JJ, Joo M, Bhatti Z, Feminella J, Dennis CG, Vethanayagam RR, Yull FE, Capitano M, Wallace PK, Minderman H, Christman JW, Sporn MB, Chan J, et al. NADPH oxidase limits innate immune responses in the lungs in mice. Plos One. 5: e9631. PMID 20300512 DOI: 10.1371/journal.pone.0009631  0.64
2010 Nagaraj S, Youn JI, Weber H, Iclozan C, Lu L, Cotter MJ, Meyer C, Becerra CR, Fishman M, Antonia S, Sporn MB, Liby KT, Rawal B, Lee JH, Gabrilovich DI. Anti-inflammatory triterpenoid blocks immune suppressive function of MDSCs and improves immune response in cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 1812-23. PMID 20215551 DOI: 10.1158/1078-0432.CCR-09-3272  0.64
2010 Honda T, Padegimas EM, David E, Sundararajan C, Liby KT, Williams C, Sporn MB, Visnick M. 2-Cyano-3,10-dioxooleana-1,9(11)-dien-28-oic acid anhydride. A novel and highly potent anti-inflammatory and cytoprotective agent. Bioorganic & Medicinal Chemistry Letters. 20: 2275-8. PMID 20188548 DOI: 10.1016/j.bmcl.2010.02.007  0.64
2010 Cano M, Thimmalappula R, Fujihara M, Nagai N, Sporn M, Wang AL, Neufeld AH, Biswal S, Handa JT. Cigarette smoking, oxidative stress, the anti-oxidant response through Nrf2 signaling, and Age-related Macular Degeneration. Vision Research. 50: 652-64. PMID 19703486 DOI: 10.1016/j.visres.2009.08.018  0.36
2009 Liby K, Risingsong R, Royce DB, Williams CR, Ma T, Yore MM, Sporn MB. Triterpenoids CDDO-methyl ester or CDDO-ethyl amide and rexinoids LG100268 or NRX194204 for prevention and treatment of lung cancer in mice. Cancer Prevention Research (Philadelphia, Pa.). 2: 1050-8. PMID 19952361 DOI: 10.1158/1940-6207.CAPR-09-0085  0.64
2009 Shin S, Wakabayashi J, Yates MS, Wakabayashi N, Dolan PM, Aja S, Liby KT, Sporn MB, Yamamoto M, Kensler TW. Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide. European Journal of Pharmacology. 620: 138-44. PMID 19698707 DOI: 10.1016/j.ejphar.2009.08.022  0.64
2009 Reddy NM, Suryanaraya V, Yates MS, Kleeberger SR, Hassoun PM, Yamamoto M, Liby KT, Sporn MB, Kensler TW, Reddy SP. The triterpenoid CDDO-imidazolide confers potent protection against hyperoxic acute lung injury in mice. American Journal of Respiratory and Critical Care Medicine. 180: 867-74. PMID 19679692 DOI: 10.1164/rccm.200905-0670OC  0.64
2009 Pitha-Rowe I, Liby K, Royce D, Sporn M. Synthetic triterpenoids attenuate cytotoxic retinal injury: cross-talk between Nrf2 and PI3K/AKT signaling through inhibition of the lipid phosphatase PTEN. Investigative Ophthalmology & Visual Science. 50: 5339-47. PMID 19494206 DOI: 10.1167/iovs.09-3648  0.64
2009 Yang L, Calingasan NY, Thomas B, Chaturvedi RK, Kiaei M, Wille EJ, Liby KT, Williams C, Royce D, Risingsong R, Musiek ES, Morrow JD, Sporn M, Beal MF. Neuroprotective effects of the triterpenoid, CDDO methyl amide, a potent inducer of Nrf2-mediated transcription. Plos One. 4: e5757. PMID 19484125 DOI: 10.1371/journal.pone.0005757  0.64
2009 Nagai N, Thimmulappa RK, Cano M, Fujihara M, Izumi-Nagai K, Kong X, Sporn MB, Kensler TW, Biswal S, Handa JT. Nrf2 is a critical modulator of the innate immune response in a model of uveitis. Free Radical Biology & Medicine. 47: 300-6. PMID 19410644 DOI: 10.1016/j.freeradbiomed.2009.04.033  0.4
2009 Yates MS, Tran QT, Dolan PM, Osburn WO, Shin S, McCulloch CC, Silkworth JB, Taguchi K, Yamamoto M, Williams CR, Liby KT, Sporn MB, Sutter TR, Kensler TW. Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice. Carcinogenesis. 30: 1024-31. PMID 19386581 DOI: 10.1093/carcin/bgp100  0.64
2009 Soriano FX, Baxter P, Murray LM, Sporn MB, Gillingwater TH, Hardingham GE. Transcriptional regulation of the AP-1 and Nrf2 target gene sulfiredoxin. Molecules and Cells. 27: 279-82. PMID 19326073 DOI: 10.1007/s10059-009-0050-y  0.64
2009 Sogno I, Vannini N, Lorusso G, Cammarota R, Noonan DM, Generoso L, Sporn MB, Albini A. Anti-angiogenic activity of a novel class of chemopreventive compounds: oleanic acid terpenoids. Recent Results in Cancer Research. Fortschritte Der Krebsforschung. ProgrèS Dans Les Recherches Sur Le Cancer. 181: 209-12. PMID 19213570  0.64
2009 Dumont M, Wille E, Calingasan NY, Tampellini D, Williams C, Gouras GK, Liby K, Sporn M, Nathan C, Flint Beal M, Lin MT. Triterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer's disease. Journal of Neurochemistry. 109: 502-12. PMID 19200343 DOI: 10.1111/j.1471-4159.2009.05970.x  0.64
2009 Sussan TE, Rangasamy T, Blake DJ, Malhotra D, El-Haddad H, Bedja D, Yates MS, Kombairaju P, Yamamoto M, Liby KT, Sporn MB, Gabrielson KL, Champion HC, Tuder RM, Kensler TW, et al. Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice. Proceedings of the National Academy of Sciences of the United States of America. 106: 250-5. PMID 19104057 DOI: 10.1073/pnas.0804333106  0.64
2009 Dumont M, Wille E, Calingasan NY, Tampellini D, Williams C, Gouras GK, Liby K, Sporn M, Nathan C, Beal MF, Lin MT. Triterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer's disease: (Journal of Neurochemistry (2009) 109 (502-512)) Journal of Neurochemistry. 109: 1192. DOI: 10.1111/j.1471-4159.2009.06053.x  0.64
2008 Sporn MB, Hong WK. Clinical prevention of recurrence of colorectal adenomas by the combination of difluoromethylornithine and sulindac: an important milestone. Cancer Prevention Research (Philadelphia, Pa.). 1: 9-11. PMID 19138930 DOI: 10.1158/1940-6207.CAPR-08-0049  0.64
2008 Burrage PS, Schmucker AC, Ren Y, Sporn MB, Brinckerhoff CE. Retinoid X receptor and peroxisome proliferator-activated receptor-gamma agonists cooperate to inhibit matrix metalloproteinase gene expression. Arthritis Research & Therapy. 10: R139. PMID 19046432 DOI: 10.1186/ar2564  0.64
2008 Sporn MB, Hong WK. Concomitant DFMO and sulindac chemoprevention of colorectal adenomas: a major clinical advance. Nature Clinical Practice. Oncology. 5: 628-9. PMID 18725921 DOI: 10.1038/ncponc1221  0.64
2008 Liby K, Yore MM, Roebuck BD, Baumgartner KJ, Honda T, Sundararajan C, Yoshizawa H, Gribble GW, Williams CR, Risingsong R, Royce DB, Dinkova-Kostova AT, Stephenson KK, Egner PA, Yates MS, ... ... Sporn MB, et al. A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin Cancer Research. 68: 6727-6733. PMID 18701497 DOI: 10.1158/0008-5472.CAN-08-1123  0.64
2008 Liby K, Risingsong R, Royce DB, R. Williams C, Yore MM, Honda T, Gribble GW, Lamph WW, Vannini N, Sogno I, Albini A, Sporn MB. Prevention and treatment of experimental estrogen receptor- negative mammary carcinogenesis by the synthetic triterpenoid CDDO-methyl ester and the rexinoid LG100268 Clinical Cancer Research. 14: 4556-4563. PMID 18628471 DOI: 10.1158/1078-0432.CCR-08-0040  0.64
2008 Liby K, Black CC, Royce DB, Williams CR, Risingsong R, Yore MM, Liu X, Honda T, Gribble GW, Lamph WW, Sporn TA, Dmitrovsky E, Sporn MB. The rexinoid LG100268 and the synthetic triterpenoid CDDO-methyl amide are more potent than erlotinib for prevention of mouse lung carcinogenesis Molecular Cancer Therapeutics. 7: 1251-1257. PMID 18483313 DOI: 10.1158/1535-7163.MCT-08-0023  0.64
2008 Osburn WO, Yates MS, Dolan PD, Chen S, Liby KT, Sporn MB, Taguchi K, Yamamoto M, Kensler TW. Genetic or pharmacologic amplification of nrf2 signaling inhibits acute inflammatory liver injury in mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 104: 218-27. PMID 18417483 DOI: 10.1093/toxsci/kfn079  0.64
2008 To C, Kulkarni S, Pawson T, Honda T, Gribble GW, Sporn MB, Wrana JL, Di Guglielmo GM. The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid-imidazolide alters transforming growth factor β-dependent signaling and cell migration by affecting the cytoskeleton and the polarity complex Journal of Biological Chemistry. 283: 11700-11713. PMID 18283107 DOI: 10.1074/jbc.M704064200  0.64
2008 Alabran JL, Cheuk A, Liby K, Sporn M, Khan J, Letterio J, Leskov KS. Human neuroblastoma cells rapidly enter cell cycle arrest and apoptosis following exposure to C-28 derivatives of the synthetic triterpenoid CDDO. Cancer Biology & Therapy. 7: 709-17. PMID 18277094 DOI: 10.4161/cbt.7.5.5713  0.64
2008 Dinkova-Kostova AT, Jenkins SN, Wehage SL, Huso DL, Benedict AL, Stephenson KK, Fahey JW, Liu H, Liby KT, Honda T, Gribble GW, Sporn MB, Talalay P. A dicyanotriterpenoid induces cytoprotective enzymes and reduces multiplicity of skin tumors in UV-irradiated mice Biochemical and Biophysical Research Communications. 367: 859-865. PMID 18206646 DOI: 10.1016/j.bbrc.2008.01.026  0.64
2007 Zou W, Chen S, Liu X, Yue P, Sporn MB, Khuri FR, Sun SY. c-FLIP downregulation contributes to apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me) in human lung cancer cells. Cancer Biology & Therapy. 6: 1614-20. PMID 18253090  0.36
2007 Vannini N, Lorusso G, Cammarota R, Barberis M, Noonan DM, Sporn MB, Albini A. The synthetic oleanane triterpenoid, CDDO-methyl ester, is a potent antiangiogenic agent. Molecular Cancer Therapeutics. 6: 3139-46. PMID 18065492 DOI: 10.1158/1535-7163.MCT-07-0451  0.64
2007 Sporn MB. A new tumor suppressor gene, selective for lung cancer. Journal of the National Cancer Institute. 99: 1654-5. PMID 18000215 DOI: 10.1093/jnci/djm227  0.64
2007 Liby K, Royce DB, Risingsong R, Williams CR, Wood MD, Chandraratna RA, Sporn MB. A new rexinoid, NRX194204, prevents carcinogenesis in both the lung and mammary gland. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 6237-43. PMID 17947492 DOI: 10.1158/1078-0432.CCR-07-1342  0.64
2007 Thimmulappa RK, Fuchs RJ, Malhotra D, Scollick C, Traore K, Bream JH, Trush MA, Liby KT, Sporn MB, Kensler TW, Biswal S. Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils. Antioxidants & Redox Signaling. 9: 1963-70. PMID 17822364 DOI: 10.1089/ars.2007.1745  0.64
2007 Koschmieder S, D'Alò F, Radomska H, Schöneich C, Chang JS, Konopleva M, Kobayashi S, Levantini E, Suh N, Di Ruscio A, Voso MT, Watt JC, Santhanam R, Sargin B, Kantarjian H, ... ... Sporn MB, et al. CDDO induces granulocytic differentiation of myeloid leukemic blasts through translational up-regulation of p42 CCAAT enhancer binding protein alpha. Blood. 110: 3695-705. PMID 17671235 DOI: 10.1182/blood-2006-11-058941  0.44
2007 Liby K, Honda T, Williams CR, Risingsong R, Royce DB, Suh N, Dinkova-Kostova AT, Stephenson KK, Talalay P, Sundararajan C, Gribble GW, Sporn MB. Novel semisynthetic analogues of betulinic acid with diverse cytoprotective, antiproliferative, and proapoptotic activities Molecular Cancer Therapeutics. 6: 2113-2119. PMID 17620440 DOI: 10.1158/1535-7163.MCT-07-0180  0.64
2007 Liby KT, Yore MM, Sporn MB. Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer. Nature Reviews. Cancer. 7: 357-69. PMID 17446857 DOI: 10.1038/nrc2129  0.64
2007 Honda T, Sundararajan C, Yoshizawa H, Su X, Honda Y, Liby KT, Sporn MB, Gribble GW. Novel tricyclic compounds having acetylene groups at C-8a and cyano enones in rings A and C: Highly potent anti-inflammatory and cytoprotective agents Journal of Medicinal Chemistry. 50: 1731-1734. PMID 17367124 DOI: 10.1021/jm070141c  0.64
2007 Liby K, Royce DB, Williams CR, Risingsong R, Yore MM, Honda T, Gribble GW, Dmitrovsky E, Sporn TA, Sporn MB. The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice Cancer Research. 67: 2414-2419. PMID 17363558 DOI: 10.1158/0008-5472.CAN-06-4534  0.64
2007 Fava RA, Elliott S, Raymond L, Mollmark J, Hays E, Honda T, Gribble GW, Sporn MB, Vincenti MP. The synthetic triterpenoid TP-222 inhibits RANKL stimulation of osteoclastogenesis and matrix metalloproteinase-9 expression. The Journal of Rheumatology. 34: 1058-68. PMID 17361985  0.64
2007 Burrage PS, Huntington JT, Sporn MB, Brinckerhoff CE. Regulation of matrix metalloproteinase gene expression by a retinoid X receptor-specific ligand. Arthritis and Rheumatism. 56: 892-904. PMID 17328062 DOI: 10.1002/art.22417  0.64
2007 Yates MS, Tauchi M, Katsuoka F, Flanders KC, Liby KT, Honda T, Gribble GW, Johnson DA, Johnson JA, Burton NC, Guilarte TR, Yamamoto M, Sporn MB, Kensler TW. Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes. Molecular Cancer Therapeutics. 6: 154-62. PMID 17237276 DOI: 10.1158/1535-7163.MCT-06-0516  0.64
2007 Albini A, Sporn MB. The tumour microenvironment as a target for chemoprevention. Nature Reviews. Cancer. 7: 139-47. PMID 17218951 DOI: 10.1038/nrc2067  0.64
2007 Sporn MB, Liby K, Yore MM, Suh N, Albini A, Honda T, Sundararajan C, Gribble GW. Platforms and networks in triterpenoid pharmacology Drug Development Research. 68: 174-182. DOI: 10.1002/ddr.20179  0.64
2006 Yore MM, Liby KT, Honda T, Gribble GW, Sporn MB. The synthetic triterpenoid 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole blocks nuclear factor-kappaB activation through direct inhibition of IkappaB kinase beta. Molecular Cancer Therapeutics. 5: 3232-9. PMID 17148759 DOI: 10.1158/1535-7163.MCT-06-0444  0.64
2006 Thimmulappa RK, Scollick C, Traore K, Yates M, Trush MA, Liby KT, Sporn MB, Yamamoto M, Kensler TW, Biswal S. Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide. Biochemical and Biophysical Research Communications. 351: 883-9. PMID 17097057 DOI: 10.1016/j.bbrc.2006.10.102  0.64
2006 Liby K, Rendi M, Suh N, Royce DB, Risingsong R, Williams CR, Lamph W, Labrie F, Krajewski S, Xu X, Kim H, Brown P, Sporn MB. The combination of the rexinoid, LG100268, and a selective estrogen receptor modulator, either arzoxifene or acolbifene, synergizes in the prevention and treatment of mammary tumors in an estrogen receptor-negative model of breast cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 5902-9. PMID 17020999 DOI: 10.1158/1078-0432.CCR-06-1119  0.64
2006 Honda T, Liby KT, Su X, Sundararajan C, Honda Y, Suh N, Risingsong R, Williams CR, Royce DB, Sporn MB, Gribble GW. Design, synthesis, and anti-inflammatory activity both in vitro and in vivo of new betulinic acid analogues having an enone functionality in ring A. Bioorganic & Medicinal Chemistry Letters. 16: 6306-9. PMID 16996735 DOI: 10.1016/j.bmcl.2006.09.012  0.64
2006 Liby K, Voong N, Williams CR, Risingsong R, Royce DB, Honda T, Gribble GW, Sporn MB, Letterio JJ. The synthetic triterpenoid CDDO-Imidazolide suppresses STAT phosphorylation and induces apoptosis in myeloma and lung cancer cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 4288-93. PMID 16857804 DOI: 10.1158/1078-0432.CCR-06-0215  0.64
2006 Sporn MB. Dichotomies in cancer research: some suggestions for a new synthesis. Nature Clinical Practice. Oncology. 3: 364-73. PMID 16826217 DOI: 10.1038/ncponc0536  0.64
2006 Ji Y, Lee HJ, Goodman C, Uskokovic M, Liby K, Sporn M, Suh N. The synthetic triterpenoid CDDO-imidazolide induces monocytic differentiation by activating the Smad and ERK signaling pathways in HL60 leukemia cells. Molecular Cancer Therapeutics. 5: 1452-8. PMID 16818503 DOI: 10.1158/1535-7163.MCT-06-0136  0.64
2006 Yates MS, Kwak MK, Egner PA, Groopman JD, Bodreddigari S, Sutter TR, Baumgartner KJ, Roebuck BD, Liby KT, Yore MM, Honda T, Gribble GW, Sporn MB, Kensler TW. Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole. Cancer Research. 66: 2488-94. PMID 16489057 DOI: 10.1158/0008-5472.CAN-05-3823  0.64
2006 Couch RD, Ganem NJ, Zhou M, Popov VM, Honda T, Veenstra TD, Sporn MB, Anderson AC. 2-cyano-3,12-dioxooleana-1,9(11)-diene-28-oic acid disrupts microtubule polymerization: a possible mechanism contributing to apoptosis. Molecular Pharmacology. 69: 1158-65. PMID 16407469 DOI: 10.1124/mol.105.018572  0.64
2006 Sporn MB. The early history of TGF-beta, and a brief glimpse of its future. Cytokine & Growth Factor Reviews. 17: 3-7. PMID 16290110 DOI: 10.1016/j.cytogfr.2005.09.012  0.64
2005 Sporn MB, Liby KT. Cancer chemoprevention: scientific promise, clinical uncertainty. Nature Clinical Practice. Oncology. 2: 518-25. PMID 16205771 DOI: 10.1038/ncponc0319  0.64
2005 Samudio I, Konopleva M, Hail N, Shi YX, McQueen T, Hsu T, Evans R, Honda T, Gribble GW, Sporn M, Gilbert HF, Safe S, Andreeff M. 2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer. The Journal of Biological Chemistry. 280: 36273-82. PMID 16118208 DOI: 10.1074/jbc.M507518200  0.64
2005 Hyer ML, Croxton R, Krajewska M, Krajewski S, Kress CL, Lu M, Suh N, Sporn MB, Cryns VL, Zapata JM, Reed JC. Synthetic triterpenoids cooperate with tumor necrosis factor-related apoptosis-inducing ligand to induce apoptosis of breast cancer cells. Cancer Research. 65: 4799-808. PMID 15930300 DOI: 10.1158/0008-5472.CAN-04-3319  0.44
2005 Liby K, Hock T, Yore MM, Suh N, Place AE, Risingsong R, Williams CR, Royce DB, Honda T, Honda Y, Gribble GW, Hill-Kapturczak N, Agarwal A, Sporn MB. The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling. Cancer Research. 65: 4789-98. PMID 15930299 DOI: 10.1158/0008-5472.CAN-04-4539  0.64
2005 Couch RD, Browning RG, Honda T, Gribble GW, Wright DL, Sporn MB, Anderson AC. Studies on the reactivity of CDDO, a promising new chemopreventive and chemotherapeutic agent: implications for a molecular mechanism of action. Bioorganic & Medicinal Chemistry Letters. 15: 2215-9. PMID 15837296 DOI: 10.1016/j.bmcl.2005.03.031  0.64
2005 Dinkova-Kostova AT, Liby KT, Stephenson KK, Holtzclaw WD, Gao X, Suh N, Williams C, Risingsong R, Honda T, Gribble GW, Sporn MB, Talalay P. Extremely potent triterpenoid inducers of the phase 2 response: Correlations of protection against oxidant and inflammatory stress Proceedings of the National Academy of Sciences of the United States of America. 102: 4584-4589. PMID 15767573 DOI: 10.1073/pnas.0500815102  0.64
2005 Vázquez N, Greenwell-Wild T, Marinos NJ, Swaim WD, Nares S, Ott DE, Schubert U, Henklein P, Orenstein JM, Sporn MB, Wahl SM. Human immunodeficiency virus type 1-induced macrophage gene expression includes the p21 gene, a target for viral regulation. Journal of Virology. 79: 4479-91. PMID 15767448 DOI: 10.1128/JVI.79.7.4479-4491.2005  0.64
2004 Konopleva M, Tsao T, Estrov Z, Lee RM, Wang RY, Jackson CE, McQueen T, Monaco G, Munsell M, Belmont J, Kantarjian H, Sporn MB, Andreeff M. The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces caspase-dependent and -independent apoptosis in acute myelogenous leukemia. Cancer Research. 64: 7927-35. PMID 15520199 DOI: 10.1158/0008-5472.CAN-03-2402  0.64
2004 Zou W, Liu X, Yue P, Zhou Z, Sporn MB, Lotan R, Khuri FR, Sun SY. c-Jun NH2-terminal kinase-mediated up-regulation of death receptor 5 contributes to induction of apoptosis by the novel synthetic triterpenoid methyl-2-cyano-3,12-dioxooleana-1, 9-dien-28-oate in human lung cancer cells. Cancer Research. 64: 7570-8. PMID 15492284 DOI: 10.1158/0008-5472.CAN-04-1238  0.64
2004 Mix KS, Sporn MB, Brinckerhoff CE, Eyre D, Schurman DJ. Novel inhibitors of matrix metalloproteinase gene expression as potential therapies for arthritis. Clinical Orthopaedics and Related Research. S129-37. PMID 15480055 DOI: 10.1097/01.blo.0000144483.62033.8b  0.64
2004 Honda T, Janosik T, Honda Y, Han J, Liby KT, Williams CR, Couch RD, Anderson AC, Sporn MB, Gribble GW. Design, synthesis, and biological evaluation of biotin conjugates of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid for the isolation of the protein targets. Journal of Medicinal Chemistry. 47: 4923-32. PMID 15369396 DOI: 10.1021/jm049727e  0.64
2004 Sporn MB. Arzoxifene: a promising new selective estrogen receptor modulator for clinical chemoprevention of breast cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 5313-5. PMID 15328166 DOI: 10.1158/1078-0432.CCR-04-1377  0.64
2004 Sporn MB, Dowsett SA, Mershon J, Bryant HU. Role of raloxifene in breast cancer prevention in postmenopausal women: clinical evidence and potential mechanisms of action. Clinical Therapeutics. 26: 830-40. PMID 15262454 DOI: 10.1016/S0149-2918(04)90127-0  0.64
2004 Rendi MH, Suh N, Lamph WW, Krajewski S, Reed JC, Heyman RA, Berchuck A, Liby K, Risingsong R, Royce DB, Williams CR, Sporn MB. The selective estrogen receptor modulator arzoxifene and the rexinoid LG100268 cooperate to promote transforming growth factor beta-dependent apoptosis in breast cancer. Cancer Research. 64: 3566-71. PMID 15150113 DOI: 10.1158/0008-5472.CAN-04-0234  0.64
2004 Dragnev KH, Pitha-Rowe I, Ma Y, Petty WJ, Sekula D, Murphy B, Rendi M, Suh N, Desai NB, Sporn MB, Freemantle SJ, Dmitrovsky E. Specific chemopreventive agents trigger proteasomal degradation of G1 cyclins: implications for combination therapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 2570-7. PMID 15073138  0.44
2004 Chauhan D, Li G, Podar K, Hideshima T, Shringarpure R, Catley L, Mitsiades C, Munshi N, Tai YT, Suh N, Gribble GW, Honda T, Schlossman R, Richardson P, Sporn MB, et al. The bortezomib/proteasome inhibitor PS-341 and triterpenoid CDDO-Im induce synergistic anti-multiple myeloma (MM) activity and overcome bortezomib resistance. Blood. 103: 3158-66. PMID 15070698 DOI: 10.1182/blood-2003-08-2873  0.64
2004 Mix KS, Coon CI, Rosen ED, Suh N, Sporn MB, Brinckerhoff CE. Peroxisome proliferator-activated receptor-gamma-independent repression of collagenase gene expression by 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid and prostaglandin 15-deoxy-delta(12,14) J2: a role for Smad signaling. Molecular Pharmacology. 65: 309-18. PMID 14742672 DOI: 10.1124/mol.65.2.309  0.64
2004 Pedersen IM, Zapata JM, Samuel T, Scott FL, Salvesen GS, Honda T, Gribble GW, Suh N, Sporn MB, Kipps TJ, Reed JC. Retraction: The triterpenoid CDDO-Imidazolide induces apoptosis and enhances fludarabine-induced apoptosis of CLL B-cells. Blood. 104: 932. PMID 14739219 DOI: 10.1182/blood-2003-11-3774  0.64
2004 Hail N, Konopleva M, Sporn M, Lotan R, Andreeff M. Evidence supporting a role for calcium in apoptosis induction by the synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO). The Journal of Biological Chemistry. 279: 11179-87. PMID 14711815 DOI: 10.1074/jbc.M312758200  0.64
2003 Honda T, Favaloro FG, Janosik T, Honda Y, Suh N, Sporn MB, Gribble GW. Efficient synthesis of (-)- and (+)-tricyclic compounds with enone functionalities in rings A and C. A novel class of orally active anti-inflammatory and cancer chemopreventive agents. Organic & Biomolecular Chemistry. 1: 4384-91. PMID 14685310 DOI: 10.1039/b307491a  0.64
2003 Elliott S, Hays E, Mayor M, Sporn M, Vincenti M. The triterpenoid CDDO inhibits expression of matrix metalloproteinase-1, matrix metalloproteinase-13 and Bcl-3 in primary human chondrocytes Arthritis Research &Amp; Therapy. 5. PMID 12932292 DOI: 10.1186/ar792  0.64
2003 Suh WS, Kim YS, Schimmer AD, Kitada S, Minden M, Andreeff M, Suh N, Sporn M, Reed JC. Synthetic triterpenoids activate a pathway for apoptosis in AML cells involving downregulation of FLIP and sensitization to TRAIL Leukemia. 17: 2122-2129. PMID 12931220 DOI: 10.1038/sj.leu.2403112  0.64
2003 Place AE, Suh N, Williams CR, Risingsong R, Honda T, Honda Y, Gribble GW, Leesnitzer LM, Stimmel JB, Willson TM, Rosen E, Sporn MB. The novel synthetic triterpenoid, CDDO-imidazolide, inhibits inflammatory response and tumor growth in vivo. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 9: 2798-806. PMID 12855660  0.64
2003 Suh N, Roberts AB, Birkey Reffey S, Miyazono K, Itoh S, ten Dijke P, Heiss EH, Place AE, Risingsong R, Williams CR, Honda T, Gribble GW, Sporn MB. Synthetic triterpenoids enhance transforming growth factor beta/Smad signaling. Cancer Research. 63: 1371-6. PMID 12649201  0.64
2003 Brinckerhoff CE, Sporn MB. Retinoids and rexinoids for the 21st century: a brave new world for arthritis. The Journal of Rheumatology. 30: 211-3. PMID 12563669  0.64
2002 Kim KB, Lotan R, Yue P, Sporn MB, Suh N, Gribble GW, Honda T, Wu GS, Hong WK, Sun SY. Identification of a novel synthetic triterpenoid, methyl-2-cyano-3,12-dioxooleana-1,9-dien-28-oate, that potently induces caspase-mediated apoptosis in human lung cancer cells. Molecular Cancer Therapeutics. 1: 177-84. PMID 12467212  0.64
2002 Favaloro FG, Honda T, Honda Y, Gribble GW, Suh N, Risingsong R, Sporn MB. Design and synthesis of tricyclic compounds with enone functionalities in rings A and C: a novel class of highly active inhibitors of nitric oxide production in mouse macrophages. Journal of Medicinal Chemistry. 45: 4801-5. PMID 12383005 DOI: 10.1021/jm025565f  0.64
2002 Suh N, Lamph WW, Glasebrook AL, Grese TA, Palkowitz AD, Williams CR, Risingsong R, Farris MR, Heyman RA, Sporn MB. Prevention and treatment of experimental breast cancer with the combination of a new selective estrogen receptor modulator, arzoxifene, and a new rexinoid, LG 100268. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 8: 3270-5. PMID 12374698  0.44
2002 Pedersen IM, Kitada S, Schimmer A, Kim Y, Zapata JM, Charboneau L, Rassenti L, Andreeff M, Bennett F, Sporn MB, Liotta LD, Kipps TJ, Reed JC. The triterpenoid CDDO induces apoptosis in refractory CLL B cells. Blood. 100: 2965-72. PMID 12351409 DOI: 10.1182/blood-2002-04-1174  0.64
2002 Sporn MB, Suh N. Chemoprevention: an essential approach to controlling cancer. Nature Reviews. Cancer. 2: 537-43. PMID 12094240 DOI: 10.1038/nrc844  0.64
2002 Kim Y, Suh N, Sporn M, Reed JC. An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis. The Journal of Biological Chemistry. 277: 22320-9. PMID 11940602 DOI: 10.1074/jbc.M202458200  0.44
2002 Honda T, Honda Y, Favaloro FG, Gribble GW, Suh N, Place AE, Rendi MH, Sporn MB. A novel dicyanotriterpenoid, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-onitrile, active at picomolar concentrations for inhibition of nitric oxide production. Bioorganic & Medicinal Chemistry Letters. 12: 1027-30. PMID 11909709 DOI: 10.1016/S0960-894X(02)00105-1  0.64
2002 Stadheim TA, Suh N, Ganju N, Sporn MB, Eastman A. The novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) potently enhances apoptosis induced by tumor necrosis factor in human leukemia cells. The Journal of Biological Chemistry. 277: 16448-55. PMID 11880365 DOI: 10.1074/jbc.M108974200  0.44
2002 Sporn MB. Hobson's choice and the need for combinations of new agents for the prevention and treatment of breast cancer. Journal of the National Cancer Institute. 94: 242-3. PMID 11854381  0.64
2002 Konopleva M, Tsao T, Ruvolo P, Stiouf I, Estrov Z, Leysath CE, Zhao S, Harris D, Chang S, Jackson CE, Munsell M, Suh N, Gribble G, Honda T, May WS, ... Sporn MB, et al. Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia. Blood. 99: 326-35. PMID 11756188 DOI: 10.1182/blood.V99.1.326  0.64
2001 Suh N, Glasebrook AL, Palkowitz AD, Bryant HU, Burris LL, Starling JJ, Pearce HL, Williams C, Peer C, Wang Y, Sporn MB. Arzoxifene, a new selective estrogen receptor modulator for chemoprevention of experimental breast cancer. Cancer Research. 61: 8412-5. PMID 11731420  0.44
2001 Sporn MB, Suh N, Mangelsdorf DJ. Prospects for prevention and treatment of cancer with selective PPARγ modulators (SPARMs) Trends in Molecular Medicine. 7: 395-400. PMID 11530334 DOI: 10.1016/S1471-4914(01)02100-1  0.64
2001 Mix KS, Mengshol JA, Benbow U, Vincenti MP, Sporn MB, Brinckerhoff CE. A synthetic triterpenoid selectively inhibits the induction of matrix metalloproteinases 1 and 13 by inflammatory cytokines Arthritis and Rheumatism. 44: 1096-1104. PMID 11352241 DOI: 10.1002/1529-0131(200105)44:5<1096::AID-ANR190>3.0.CO;2-6  0.64
2000 Honda T, Rounds BV, Bore L, Finlay HJ, Favaloro FG, Suh N, Wang Y, Sporn MB, Gribble GW. Synthetic oleanane and ursane triterpenoids with modified rings A and C: a series of highly active inhibitors of nitric oxide production in mouse macrophages. Journal of Medicinal Chemistry. 43: 4233-46. PMID 11063620 DOI: 10.1021/jm0002230  0.64
2000 Wang Y, Porter WW, Suh N, Honda T, Gribble GW, Leesnitzer LM, Plunket KD, Mangelsdorf DJ, Blanchard SG, Willson TM, Sporn MB. A synthetic triterpenoid, 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO), is a ligand for the peroxisome proliferator-activated receptor gamma. Molecular Endocrinology (Baltimore, Md.). 14: 1550-6. PMID 11043571 DOI: 10.1210/mend.14.10.0545  0.64
2000 Sporn MB. Retinoids and demethylating agents - Looking for partners Journal of the National Cancer Institute. 92: 780-781. PMID 10814663  0.64
2000 Subbaramaiah K, Michaluart P, Sporn MB, Dannenberg AJ. Ursolic acid inhibits cyclooxygenase-2 transcription in human mammary epithelial cells Cancer Research. 60: 2399-2404. PMID 10811116  0.64
2000 Honda T, Gribble GW, Suh N, Finlay HJ, Rounds BV, Bore L, Favaloro FG, Wang Y, Sporn MB. Novel synthetic oleanane and ursane triterpenoids with various enone functionalities in ring A as inhibitors of nitric oxide production in mouse macrophages. Journal of Medicinal Chemistry. 43: 1866-77. PMID 10794703 DOI: 10.1021/jm000008j  0.64
2000 Sporn MB, Suh N. Chemoprevention of cancer Carcinogenesis. 21: 525-530. PMID 10688873  0.64
2000 Sporn MB. Cytokine and growth factor: Introduction Cytokine and Growth Factor Reviews. 11: 3. DOI: 10.1016/S1359-6101(99)00023-4  0.64
1999 Sporn MB. TGF-β: 20 years and counting Microbes and Infection. 1: 1251-1253. PMID 10611752 DOI: 10.1016/S1286-4579(99)00260-9  0.64
1999 Suh N, Wang Y, Williams CR, Risingsong R, Gilmer T, Willson TM, Sporn MB. A new ligand for the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), GW7845, inhibits rat mammary carcinogenesis. Cancer Research. 59: 5671-3. PMID 10582681  0.44
1999 Sporn MB. New agents for chemoprevention of prostate cancer European Urology. 35: 420-423. PMID 10325499 DOI: 10.1159/000019873  0.64
1999 Suh N, Wang Y, Honda T, Gribble GW, Dmitrovsky E, Hickey WF, Maue RA, Place AE, Porter DM, Spinella MJ, Williams CR, Wu G, Dannenberg AJ, Flanders KC, Letterio JJ, ... ... Sporn MB, et al. A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, with potent differentiating, antiproliferative, and anti-inflammatory activity. Cancer Research. 59: 336-41. PMID 9927043  0.64
1998 Honda T, Rounds BV, Gribble GW, Suh N, Wang Y, Sporn MB. Design and synthesis of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, a novel and highly active inhibitor of nitric oxide production in mouse macrophages. Bioorganic & Medicinal Chemistry Letters. 8: 2711-4. PMID 9873608  0.44
1998 Lucia MS, Sporn MB, Roberts AB, Stewart LV, Danielpour D. The role of transforming growth factor-β1, -β2, and -β3 in androgen-responsive growth of NRP-152 rat prostatic epithelial cells Journal of Cellular Physiology. 175: 184-192. PMID 9525477 DOI: 10.1002/(SICI)1097-4652(199805)175:2<184::AID-JCP8>3.0.CO;2-K  0.64
1997 Sporn MB. The war on cancer: A review Annals of the New York Academy of Sciences. 833: 137-146. PMID 9616746 DOI: 10.1111/j.1749-6632.1997.tb48599.x  0.64
1997 Hong WK, Sporn MB. Recent advances in chemoprevention of cancer Science. 278: 1073-1077. PMID 9353183 DOI: 10.1126/science.278.5340.1073  0.64
1997 Sporn MB. The importance of context in cytokine action Kidney International. 51: 1352-1354. PMID 9150443  0.64
1997 Finlay HJ, Honda T, Gribble GW, Danielpour D, Benoit NE, Suh N, Williams C, Sporn MB. Novel A-ring cleaved analogs of oleanolic and ursolic acids which affect growth regulation in NRP.152 prostate cells Bioorganic and Medicinal Chemistry Letters. 7: 1769-1772. DOI: 10.1016/S0960-894X(97)00310-7  0.64
1996 Qian SW, Burmester JK, Tsang MLS, Weatherbee JA, Hinck AP, Ohlsen DJ, Sporn MB, Roberts AB. Binding affinity of transforming growth factor-β for its type II receptor is determined by the C-terminal region of the molecule Journal of Biological Chemistry. 271: 30656-30662. PMID 8940041 DOI: 10.1074/jbc.271.48.30656  0.64
1996 Vodovotz Y, Lucia MS, Flanders KC, Chesler L, Xie QW, Smith TW, Weidner J, Mumford R, Webber R, Nathan C, Roberts AB, Lippa CF, Sporn MB. Inducible nitric oxide synthase in tangle-bearing neurons of patients with Alzheimer's disease. The Journal of Experimental Medicine. 184: 1425-33. PMID 8879214 DOI: 10.1084/jem.184.4.1425  0.32
1996 Sporn MB, Vilcek JT. The inauguration of Cytokine & Growth Factor Reviews Cytokine &Amp; Growth Factor Reviews. 7: 1. PMID 8864348 DOI: 10.1016/1359-6101(96)00014-7  0.64
1996 Hinck AP, Archer SJ, Qian SW, Roberts AB, Sporn MB, Weatherbee JA, Tsang ML, Lucas R, Zhang BL, Wenker J, Torchia DA. Transforming growth factor beta 1: three-dimensional structure in solution and comparison with the X-ray structure of transforming growth factor beta 2. Biochemistry. 35: 8517-34. PMID 8679613 DOI: 10.1021/bi9604946  0.64
1996 Sporn MB. The war on cancer Lancet. 347: 1377-1381. PMID 8637346 DOI: 10.1016/S0140-6736(96)91015-6  0.64
1996 Greenberg ER, Sporn MB. Antioxidant vitamins, cancer, and cardiovascular disease New England Journal of Medicine. 334: 1189-1190. PMID 8602188 DOI: 10.1056/NEJM199605023341810  0.64
1995 Flanders KC, Lippa CF, Smith TW, Pollen DA, Sporn MB. Altered expression of transforming growth factor-beta in Alzheimer's disease. Neurology. 45: 1561-9. PMID 7543987 DOI: 10.1212/WNL.45.8.1561  0.64
1994 Muir GH, Butta A, Shearer RJ, Fisher C, Dearnaley DP, Flanders KC, Sporn MB, Colletta AA. Induction of transforming growth factor β in hormonally treated human prostate cancer British Journal of Cancer. 69: 130-134. PMID 8286194 DOI: 10.1038/bjc.1994.21  0.64
1994 Slayter MV, Anzano MA, Kadomatsu K, Smith JM, Sporn MB. Histogenesis of Induced Prostate and Seminal Vesicle Carcinoma in Lobund-Wistar Rats: A System for Histological Scoring and Grading Cancer Research. 54: 1440-1445. PMID 8137245  0.64
1994 Dey BR, Sukhatme VP, Roberts AB, Sporn MB, Rauscher FJ, Kim SJ. Repression of the transforming growth factor-β1 gene by the Wilms' tumor suppressor WT1 gene product Molecular Endocrinology. 8: 595-602. PMID 8058069 DOI: 10.1210/mend.8.5.8058069  0.64
1993 Gross CE, Bednar MM, Howard DB, Sporn MB. Transforming growth factor-beta 1 reduces infarct size after experimental cerebral ischemia in a rabbit model. Stroke; a Journal of Cerebral Circulation. 24: 558-62. PMID 8465363 DOI: 10.1161/01.STR.24.4.558  0.64
1993 Hunter KE, Sporn MB, Davies AM. Transforming growth factor-betas inhibit mitogen-stimulated proliferation of astrocytes Glia. 7: 203-211. PMID 8454307  0.64
1993 Roberts AB, Sporn MB. Physiological actions and clinical applications of transforming growth factor-β (TGF-β Growth Factors. 8: 1-9. PMID 8448037 DOI: 10.3109/08977199309029129  0.64
1993 Archer SJ, Bax A, Roberts AB, Sporn MB, Ogawa Y, Piez KA, Weatherbee JA, Tsang MLS, Lucas R, Zheng BL, Wenker J, Torchia DA. Transforming growth factor β1: Secondary structure as determined by heteronuclear magnetic resonance spectroscopy Biochemistry. 32: 1164-1171. PMID 8424943 DOI: 10.1021/bi00055a022  0.64
1993 Archer SJ, Bax A, Roberts AB, Sporn MB, Ogawa Y, Piez KA, Weatherbee JA, Tsang MLS, Lucas R, Zheng BL, Wenker J, Torchia DA. Transforming growth factor β1: NMR signal assignments of the recombinant protein expressed and isotopically enriched using chinese hamster ovary cells Biochemistry. 32: 1152-1163. PMID 8424942 DOI: 10.1021/bi00055a021  0.64
1993 Romeo DS, Park K, Roberts AB, Sporn MB, Kim SJ. An element of the transforming growth factor-beta 1 5'-untranslated region represses translation and specifically binds a cytosolic factor. Molecular Endocrinology (Baltimore, Md.). 7: 759-66. PMID 8361501 DOI: 10.1210/mend.7.6.8361501  0.44
1993 Sun JZ, Li XY, Sporn MB, Schneider MD, Roberts R, Bolli R. Effect of Transforming Growth Factor-Beta 1 on Myocardial Stunning in the Intact Dog Journal of Molecular and Cellular Cardiology. 25: 379-386. PMID 8340931 DOI: 10.1006/jmcc.1993.1044  0.64
1993 Busam KJ, Geiser AG, Roberts AB, Sporn MB. Synergistic increase of phorbol ester-induced c-fos mRNA expression by retinoic acid through stabilization of the c-fos message Oncogene. 8: 2267-2273. PMID 8336949  0.64
1993 Flanders KC, Winokur TS, Holder MG, Sporn MB. Hyperthemia induces experssion of transforming growth factor-βs in rat cardiac cells in vitro and in vivo Journal of Clinical Investigation. 92: 404-410. PMID 8326008 DOI: 10.1172/JCI116581  0.64
1993 Sporn MB, Roberts AB. A major advance in the use of growth factors to enhance wound healing Journal of Clinical Investigation. 92: 2565-2566. PMID 8254012  0.64
1993 Burmester JK, Su Wen Qian, Roberts AB, Huang A, Amatayakul-Chantler S, Suardet L, Odartchenko N, Madri JA, Sporn MB. Characterization of distinct functional domains of transforming growth factor β Proceedings of the National Academy of Sciences of the United States of America. 90: 8628-8632. PMID 7690965 DOI: 10.1073/pnas.90.18.8628  0.64
1993 Roberts AB, Sporn MB, Lefer AM. Cardioprotective actions of transforming growth factor-β Trends in Cardiovascular Medicine. 3: 77-81. DOI: 10.1016/1050-1738(93)90027-4  0.64
1992 Jakowlew SB, Cubert J, Danielpour D, Sporn MB, Roberts AB. Differential regulation of the expression of transforming growth factor-β mRNAs by growth factors and retinoic acid in chicken embryo chondrocytes, myocytes, and fibroblasts Journal of Cellular Physiology. 150: 377-385. PMID 1734039  0.64
1992 Roberts AB, Sporn MB. Differential expression of the TGF-β isoforms in embryogenesis suggests specific roles in developing and adult tissues Molecular Reproduction and Development. 32: 91-98. PMID 1637557 DOI: 10.1002/mrd.1080320203  0.64
1992 Su Wen Qian, Burmester JK, Merwin JR, Madri JA, Sporn MB, Roberts AB. Identification of a structural domain that distinguishes the actions of the type 1 and 2 isoforms of transforming growth factor β on endothelial cells Proceedings of the National Academy of Sciences of the United States of America. 89: 6290-6294. PMID 1631120 DOI: 10.1073/pnas.89.14.6290  0.64
1992 Roberts AB, McCune BK, Sporn MB. TGF-β: Regulation of extracellular matrix Kidney International. 41: 557-559. PMID 1573828  0.64
1992 Sporn MB, Roberts AB. Autocrine secretion - 10 Years later Annals of Internal Medicine. 117: 408-414. PMID 1503333 DOI: 10.7326/0003-4819-117-5-408  0.64
1992 Busam KJ, Roberts AB, Sporn MB. Inhibition of mitogen-induced c-fos expression in melanoma cells by retinoic acid involves the serum response element Journal of Biological Chemistry. 267: 19971-19977. PMID 1400313  0.64
1992 O'reilly MA, Danielpour D, Roberts AB, Sporn MB. Regulation of expression of transforming growth factor-β2 by transforming growth factor-β isoforms is dependent upon cell type Growth Factors. 6: 193-201. PMID 1389225 DOI: 10.3109/08977199209026926  0.64
1992 Racke MK, Cannella B, Albert P, Sporn M, Raine CS, McFarlin DE. Evidence of endogenous regulatory function of transforming growth factor-beta 1 in experimental allergic encephalomyelitis. International Immunology. 4: 615-20. PMID 1378298 DOI: 10.1093/intimm/4.5.615  0.64
1992 Wakefield LM, Colletta AA, McCune BK, Sporn MB. Roles for transforming growth factors-beta in the genesis, prevention, and treatment of breast cancer Cancer Treatment and Research. 61: 97-136. PMID 1360247  0.64
1992 Sporn MB, Roberts AB. Transforming growth factor-β: Recent progress and new challenges Journal of Cell Biology. 119: 1017-1022. PMID 1332976 DOI: 10.1083/jcb.119.5.1017  0.64
1992 Roberts AB, Sporn MB. Mechanistic interrelationships between two superfamilies: The steroid/retinoid receptors and transforming growth factor-β Cancer Surveys. 14: 205-220. PMID 1330304  0.64
1992 Roberts AB, Vodovotz Y, Roche NS, Sporn MB, Nathan CF. Role of nitric oxide in antagonistic effects of transforming growth factor-beta and interleukin-1 beta on the beating rate of cultured cardiac myocytes. Molecular Endocrinology (Baltimore, Md.). 6: 1921-30. PMID 1282674 DOI: 10.1210/mend.6.11.1282674  0.64
1991 Sporn MB, Roberts AB. Introduction: what is TGF-beta? Ciba Foundation Symposium. 157: 1-6. PMID 2070680 DOI: 10.1002/9780470514061.ch1  0.64
1991 Glick AB, Sporn MB, Yuspa SH. Altered regulation of TGF-β1 and TGF-α in primary keratinocytes and papillomas expressing v-Ha-ras Molecular Carcinogenesis. 4: 210-219. PMID 2064727  0.64
1991 Nathan C, Sporn M. Cytokines in context Journal of Cell Biology. 113: 981-986. PMID 2040651 DOI: 10.1083/jcb.113.5.981  0.64
1991 Roberts AB, Kim SJ, Sporn MB. Is there a common pathway mediating growth inhibition by TGF-β and the retinoblastoma gene product? Cancer Cells. 3: 19-21. PMID 2025491  0.64
1991 Sporn MB, Roberts AB. Interactions of retinoids and transforming growth factor-β in regulation of cell differentiation and proliferation Molecular Endocrinology. 5: 3-7. PMID 2017191 DOI: 10.1210/mend-5-1-3  0.64
1991 Geiser AG, Kim SJ, Roberts AB, Sporn MB. Characterization of the Mouse Transforming Growth Factor-β1 Promoter and Activation by the Ha-ras Oncogene Molecular and Cellular Biology. 11: 84-92. PMID 1986255  0.64
1991 Colletta AA, Wakefield LM, Howell FV, Danielpour D, Baum M, Sporn MB. The growth inhibition of human breast cancer cells by a novel synthetic progestin involves the induction of transforming growth factor beta. The Journal of Clinical Investigation. 87: 277-83. PMID 1985102 DOI: 10.1172/JCI114983  0.64
1991 Falanga V, Su Wen Qian, Danielpour D, Katz MH, Roberts AB, Sporn MB. Hypoxia upregulates the synthesis of tgf-β1 by human dermal fibroblasts Journal of Investigative Dermatology. 97: 634-637. PMID 1940433  0.64
1991 Sporn MB. Carcinogenesis and Cancer: Different Perspectives on the Same Disease Cancer Research. 51: 6215-6218. PMID 1933881  0.64
1991 Kim SJ, Winokur TS, Lee HD, Danielpour D, Kim KY, Geiser AG, Chen LS, Sporn MB, Roberts AB, Jay G. Overexpression of transforming growth factor-β in transgenic mice carrying the human T-cell lymphotropic virus type I tax gene Molecular and Cellular Biology. 11: 5222-5228. PMID 1922042  0.64
1991 Heine UI, Burmester JK, Flanders KC, Danielpour D, Munoz EF, Roberts AB, Sporn MB. Localization of transforming growth factor-beta 1 in mitochondria of murine heart and liver Cell Regulation. 2: 467-477. PMID 1883875  0.64
1991 Danielpour D, Kim KY, Winokur TS, Sporn MB. Differential regulation of the expression of transforming growth factor-βs 1 and 2 by retinoic acid, epidermal growth factor, and dexamethasone in NRK-49F and A549 cells Journal of Cellular Physiology. 148: 235-244. PMID 1880152  0.64
1991 Horikoshi S, McCune BK, Ray PE, Kopp JB, Sporn MB, Klotman PE. Water deprivation stimulates transforming growth factor-β2 accumulation in the juxtaglomerular apparatus of mouse kidney Journal of Clinical Investigation. 88: 2117-2122. PMID 1752966  0.64
1991 Lafyatis R, Lechleider R, Roberts AB, Sporn MB. Secretion and transcriptional regulation of transforming growth factor-β3 during myogenesis Molecular and Cellular Biology. 11: 3795-3803. PMID 1710772  0.64
1991 Crowther D, Sporn MB, Roberts AB, Durie BGM. Workshop on Growth Factors Annals of Oncology. 2: 207-211. PMID 1675582  0.64
1990 Flanders KC, Cissel DS, Mullen LT, Danielpour D, Sporn MB, Roberts AB. Antibodies to transforming growth factor-β2 peptides: Specific detection of TGF-β2 in immunoassays Growth Factors. 3: 45-52. PMID 2383401 DOI: 10.3109/08977199009037501  0.64
1990 Kim SJ, Kehrl JH, Burton J, Tendler CL, Jeang KT, Danielpour D, Thevenin C, Kim KY, Sporn MB, Roberts AB. Transactivation of the transforming growth factor β1 (TGF-β1) gene by human T lymphotropic virus type 1 tax: A potential mechanism for the increased production of TGF-β1 in adult T cell leukemia Journal of Experimental Medicine. 172: 121-129. PMID 2358774  0.64
1990 Joyce ME, Roberts AB, Sporn MB, Bolander ME. Transforming growth factor-β and the initiation of chondrogenesis and osteogenesis in the rat femur Journal of Cell Biology. 110: 2195-2207. PMID 2351696 DOI: 10.1083/jcb.110.6.2195  0.64
1990 Qian SW, Kondaiah P, Roberts AB, Sporn MB. cDNA cloning by PCR of rat transforming growth factor β-1 Nucleic Acids Research. 18: 3059. PMID 2349108 DOI: 10.1093/nar/18.10.3059  0.64
1990 Roberts AB, Rosa F, Roche NS, Coligan JE, Garfield M, Rebbert ML, Kondaiah P, Danielpour D, Kehrl JH, Wahl SM, Dawid IB, Sporn MB. Isolation and characterization of TGF-β2 and TGF-β5 from medium conditioned by xenopus XTC cells Growth Factors. 2: 135-147. PMID 2340184 DOI: 10.3109/08977199009071500  0.64
1990 Jakowlew SB, Dillard PJ, Sporn MB, Roberts AB. Complementary deoxyribonucleic acid cloning of an mRNA encoding transforming growth factor- β2 from chicken embryo chondrocytes Growth Factors. 2: 123-133. PMID 2340183 DOI: 10.3109/08977199009071499  0.64
1990 Roberts AB, Kondaiah P, Rosa F, Watanabe S, Good P, Danielpour D, Roche NS, Rebbert ML, Dawid IB, Sporn MB. Mesoderm induction in Xenopus laevis distinguishes between the various TGF-beta isoforms. Growth Factors (Chur, Switzerland). 3: 277-86. PMID 2257149 DOI: 10.3109/08977199009003670  0.64
1990 Wakefield LM, Winokur TS, Hollands RS, Christopherson K, Levinson AD, Sporn MB. Recombinant latent transforming growth factor beta 1 has a longer plasma half-life in rats than active transforming growth factor beta 1, and a different tissue distribution. The Journal of Clinical Investigation. 86: 1976-84. PMID 2254455 DOI: 10.1172/JCI114932  0.64
1990 Denhez F, Lafyatis R, Kondaiah P, Roberts AB, Sporn MB. Cloning by polymerase chain reaction of a new mouse TGF-β mTGF-β3 Growth Factors. 3: 139-146. PMID 2206556 DOI: 10.3109/08977199009108276  0.64
1990 Brownh PD, Wakefiel LM, Levinson AD, Sporn MB. Physicochemical activation of recombinant latent transforming growth factor-beta's 1, 2, and 3 Growth Factors. 3: 35-43. PMID 2200452 DOI: 10.3109/08977199009037500  0.64
1990 Sporn MB, Roberts AB. The transforming growth factor-betas: Past, present, and future Annals of the New York Academy of Sciences. 593: 1-6. PMID 2197958 DOI: 10.1111/j.1749-6632.1990.tb16095.x  0.64
1990 Roberts AB, Heine UI, Flanders KC, Sporn MB. Transforming growth factor-β. Major role in regulation of extracellular matrix Annals of the New York Academy of Sciences. 580: 225-232. PMID 2186691 DOI: 10.1111/j.1749-6632.1990.tb17931.x  0.64
1990 Schwarz LC, Wright JA, Gingras MC, Kondaiah P, Danielpour D, Pimentel M, Sporn MB, Greenberg AH. Aberrant TGF-beta production and regulation in metastatic malignancy. Growth Factors (Chur, Switzerland). 3: 115-27. PMID 2169772 DOI: 10.3109/08977199009108274  0.64
1990 Sieweke MH, Thompson NL, Sporn MB, Bissell MJ. Mediation of wound-related Rous sarcoma virus tumorigenesis by TGF-beta. Science (New York, N.Y.). 248: 1656-60. PMID 2163544 DOI: 10.1126/science.2163544  0.64
1990 Van Obberghen-Schilling E, Thompson NL, Flanders KC, Sporn MB, Lambert PF, Baker CC. Transforming growth factor-beta expression in fibropapillomas induced by bovine papillomavirus type 1, in normal bovine skin, and in BPV-1-transformed cells. Growth Factors (Chur, Switzerland). 2: 111-21. PMID 2160257 DOI: 10.3109/08977199009071498  0.64
1990 Glick AB, Danielpour D, Morgan D, Sporn MB, Yuspa SH. Induction and autocrine receptor binding of transforming growth factor-β2 during terminal differentiation of primary mouse keratinocytes Molecular Endocrinology. 4: 46-52. PMID 2157977  0.64
1990 Sporn MB, Roberts AB. TGF-beta: problems and prospects Cell Regulation. 1: 875-882. PMID 2100192  0.64
1990 Wakefield LM, Sporn MB. Suppression of carcinogenesis: a role for TGF-beta and related molecules in prevention of cancer Immunology Series. 51: 217-243. PMID 2095919  0.64
1990 Danielpour D, Sporn MB. Differential inhibition of transforming growth factor β1 and β2 activity by α2-macroglobulin Journal of Biological Chemistry. 265: 6973-6977. PMID 1691181  0.64
1990 Khalil N, Bereznay O, Sporn MB, Greenberg AH. Transforming growth factor-β production and immunohistochemical localization during bleomycin-induced pulmonary inflammation Annals of the New York Academy of Sciences. 593: 350-352. DOI: 10.1111/j.1749-6632.1990.tb16141.x  0.64
1990 Flanders KC, Cissel DS, Jakowlew SB, Roberts AB, Watanabe S, Danielpour D, Sporn MB. Immunohistochemical localization of TGFβ2 and β3 in the nervous system Annals of the New York Academy of Sciences. 593: 338-339. DOI: 10.1111/j.1749-6632.1990.tb16137.x  0.64
1990 Danielpour D, Kim KY, Dart LL, Watanabe S, Roberts AB, Sporn MB. Evidence for differential regulation of TGFβ1 and TGFβ2 expression in vivo by sandwich enzyme-linked immunosorbent assays Annals of the New York Academy of Sciences. 593: 300-302. DOI: 10.1111/j.1749-6632.1990.tb16124.x  0.64
1990 Sporn MB, Roberts AB. TGF-β: Problems and prospects Molecular Biology of the Cell. 1: 875-882.  0.64
1990 Joyce ME, Jingushi S, Roberts AB, Sporn MB, Bolander ME. Transforming growth factor-β initiates cartilage and bone formation in vivo Calcium Regulation and Bone Metabolism. Basic and Clinical Aspects: Proceedings of the 10th International Conference On Calcium Regulating Hormones and Bone Metabolism. Ics886. 317-323.  0.64
1989 Danielpour D, Dart LL, Flanders KC, Roberts AB, Sporn MB. Immunodetection and quantitation of the two forms of transforming growth factor-beta (TGF-β1 and TGF-β2) secreted by cells in culture Journal of Cellular Physiology. 138: 79-86. PMID 2910889  0.64
1989 Kim SJ, Glick A, Sporn MB, Roberts AB. Characterization of the promoter region of the human transforming growth factor-β1 gene Journal of Biological Chemistry. 264: 402-408. PMID 2909528  0.64
1989 Connor TB, Roberts AB, Sporn MB, Danielpour D, Dart LL, Michels RG, De Bustros S, Enger C, Kato H, Lansing M, Hayashi H, Glaser BM. Correlation of fibrosis and transforming growth factor-β type 2 levels in the eye Journal of Clinical Investigation. 83: 1661-1666. PMID 2708527  0.64
1989 Roberts AB, Sporn MB. Regulation of endothelial cell growth, architecture, and matrix synthesis by TGF-β American Review of Respiratory Disease. 140: 1126-1128. PMID 2679267  0.64
1989 Sporn MB, Roberts AB. Transforming Growth Factor—β: Multiple Actions and Potential Clinical Applications Jama: the Journal of the American Medical Association. 262: 938-941. PMID 2666683 DOI: 10.1001/jama.1989.03430070086036  0.64
1989 Montelione GT, Winkler ME, Burton LE, Rinderknecht E, Sporn MB, Wagner G. Sequence-specific 1H-NMR assignments and identification of two small antiparallel β-sheets in the solution structure of recombinant human transforming growth factor α Proceedings of the National Academy of Sciences of the United States of America. 86: 1519-1523. PMID 2646637 DOI: 10.1073/pnas.86.5.1519  0.64
1989 Thompson NL, Flanders KC, Smith JM, Ellingsworth LR, Roberts AB, Sporn MB. Expression of transforming growth factor-beta 1 in specific cells and tissues of adult and neonatal mice. The Journal of Cell Biology. 108: 661-9. PMID 2645303 DOI: 10.1083/jcb.108.2.661  0.64
1989 Sporn MB, Roberts AB, Wakefield LM, Glick AB, Danielpour D. Transforming growth factor-beta and suppression of carcinogenesis Princess Takamatsu Symposia. 20: 259-266. PMID 2562184  0.64
1989 Glick AB, Flanders KC, Danielpour D, Yuspa SH, Sporn MB. Retinoic acid induces transforming growth factor-beta 2 in cultured keratinocytes and mouse epidermis Cell Regulation. 1: 87-97. PMID 2519621  0.64
1989 Danielpour D, Kim KY, Dart LL, Watanabe S, Roberts AB, Sporn MB. Sandwich enzyme-linked immunosorbent assays (selisas) quantitate and distinguish two forms of transforming growth factor-beta (TGF-β1 and TGF-β2) in complex biological fluids Growth Factors. 2: 61-71. PMID 2483947 DOI: 10.3109/08977198909069082  0.64
1989 Flanders KC, Thompson NL, Cissel DS, Van Obberghen-Schilling E, Baker CC, Kass ME, Ellingsworth LR, Roberts AB, Sporn MB. Transforming growth factor-beta 1: histochemical localization with antibodies to different epitopes. The Journal of Cell Biology. 108: 653-60. PMID 2465297 DOI: 10.1083/jcb.108.2.653  0.64
1988 Rosa F, Roberts AB, Danielpour D, Dart LL, Sporn MB, Dawid IB. Mesoderm induction in amphibians: the role of TGF-beta 2-like factors. Science (New York, N.Y.). 239: 783-5. PMID 3422517  0.64
1988 Lazar E, Watanabe S, Dalton S, Sporn MB. Transforming growth factor alpha: mutation of aspartic acid 47 and leucine 48 results in different biological activities Molecular and Cellular Biology. 8: 1247-1252. PMID 3285178  0.64
1988 Wakefield LM, Thompson NL, Flanders KC, O'Connor-McCourt MD, Sporn MB. Transforming growth factor-beta: multifunctional regulator of cell growth and phenotype. Annals of the New York Academy of Sciences. 551: 290-7; discussion 29. PMID 3245671 DOI: 10.1111/j.1749-6632.1988.tb22355.x  0.64
1988 Jakowlew SB, Dillard PJ, Kondaiah P, Sporn MB, Roberts AB. Complementary deoxyribonucleic acid cloning of a novel transforming growth factor-β messenger ribonucleic acid from chick embryo chondrocytes Molecular Endocrinology. 2: 747-755. PMID 3211158 DOI: 10.1210/mend-2-8-747  0.64
1988 Krummel TM, Michna BA, Thomas BL, Sporn MB, Nelson JM, Salzberg AM, Cohen IK, Diegelmann RF. Transforming growth factor beta (TGF-beta) induces fibrosis in a fetal wound model. Journal of Pediatric Surgery. 23: 647-52. PMID 3204464 DOI: 10.1016/S0022-3468(88)80638-9  0.64
1988 Jakowlew SB, Dillard PJ, Sporn MB, Roberts AB. Nucleotide sequence of chicken transforming growth factor-beta 1 (TGF-β 1) Nucleic Acids Research. 16: 8730. PMID 3166520 DOI: 10.1093/nar/16.17.8730  0.64
1988 Wakefield LM, Smith DM, Flanders KC, Sporn MB. Latent transforming growth factor-β from human platelets. A high molecular weight complex containing precursor sequences Journal of Biological Chemistry. 263: 7646-7654. PMID 3163692  0.64
1988 Thompson NL, Bazoberry F, Speir EH, Casscells W, Ferrans VJ, Flanders KC, Kondaiah P, Geiser AG, Sporn MB. Transforming growth factor beta-1 in acute myocardial infarction in rats. Growth Factors (Chur, Switzerland). 1: 91-9. PMID 3078566 DOI: 10.3109/08977198809000251  0.64
1988 Sporn MB, Roberts AB. Transforming growth factor-beta: New chemical forms and new biologic roles Biofactors. 1: 89-93. PMID 3076435  0.64
1988 Roberts AB, Flanders KC, Kondaiah P, Thompson NL, Van Obberghen-Schilling E, Wakefield L, Rossi P, de Crombrugghe B, Heine U, Sporn MB. Transforming growth factor beta: biochemistry and roles in embryogenesis, tissue repair and remodeling, and carcinogenesis. Recent Progress in Hormone Research. 44: 157-97. PMID 3064207 DOI: 10.1016/B978-0-12-571144-9.50010-7  0.64
1988 Roberts AB, Thompson NL, Heine U, Flanders C, Sporn MB. Transforming growth factor-beta: possible roles in carcinogenesis. British Journal of Cancer. 57: 594-600. PMID 3044431 DOI: 10.1038/bjc.1988.135  0.64
1988 Tsunawaki S, Sporn M, Ding A, Nathan C. Deactivation of macrophages by transforming growth factor-β Nature. 334: 260-262. PMID 3041283  0.64
1988 Roberts AB, Sporn MB. Transforming Growth Factor β Advances in Cancer Research. 51: 107-145. PMID 2906217 DOI: 10.1016/S0065-230X(08)60221-3  0.64
1988 Sporn MB, Roberts AB. Peptide growth factors are multifunctional Nature. 332: 217-219. PMID 2831460  0.64
1988 Jakowlew SB, Dillard PJ, Sporn MB, Roberts AB. Complementary deoxyribonucleic acid cloning of a messenger ribonucleic acid encoding transforming growth factor β 4 from chicken embryo chondrocytes Molecular Endocrinology. 2: 1186-1195. PMID 2464131  0.64
1988 Mulé JJ, Schwarz SL, Roberts AB, Sporn MB, Rosenberg SA. Transforming growth factor-beta inhibits the in vitro generation of lymphokine-activated killer cells and cytotoxic T cells Cancer Immunology Immunotherapy. 26: 95-100. PMID 2452015 DOI: 10.1007/BF00205600  0.64
1987 Watanabe S, Lazar E, Sporn MB. Transformation of normal rat kidney (NRK) cells by an infectious retrovirus carrying a synthetic rat type α transforming growth factor gene Proceedings of the National Academy of Sciences of the United States of America. 84: 1258-1262. PMID 3469667  0.64
1987 Heine U, Munoz EF, Flanders KC, Ellingsworth LR, Lam HY, Thompson NL, Roberts AB, Sporn MB. Role of transforming growth factor-beta in the development of the mouse embryo. The Journal of Cell Biology. 105: 2861-76. PMID 3320058 DOI: 10.1083/jcb.105.6.2861  0.64
1987 Sporn MB, Roberts AB, Wakefield LM, De Crombrugghe B. Some recent advances in the chemistry and biology of transforming growth factor-beta Journal of Cell Biology. 105: 1039-1045. PMID 3308901  0.64
1987 Roberts AB, Sporn MB. Transforming growth factor-beta: Potential common mechanisms mediating its effects on embryogenesis, inflammation-repair and carcinogenesis Nuclear Medicine and Biology. 14: 435-439. PMID 3308784  0.64
1987 Sporn MB, Roberts AB. Peptide growth factors: current status and therapeutic opportunities Important Advances in Oncology. 75-86. PMID 2456983  0.64
1987 Roberts AB, Sporn MB. Transforming growth factor-beta: Potential common mechanisms mediating its effects on embryogenesis, inflammation-repair, and carcinogehesis International Journal of Radiation Applications and Instrumentation.. 14: 435-439. DOI: 10.1016/0883-2897(87)90020-1  0.64
1986 Roberts AB, Sporn MB. Growth factors and transformation Cancer Surveys. 5: 405-412. PMID 3779661  0.64
1986 Sporn MB, Roberts AB. Peptide growth factors and inflammation, tissue repair, and cancer Journal of Clinical Investigation. 78: 329-332. PMID 3525608  0.64
1986 Sporn MB, Roberts AB, Wakefield LM, Assoian RK. Transforming growth factor factor-β: Biological function and chemical structure Science. 233: 532-534. PMID 3487831 DOI: 10.1126/science.3487831  0.64
1986 Assoian RK, Sporn MB. Type β transforming growth factor in human platelets: Release during platelet degranulation and action on vascular smooth muscle cells Journal of Cell Biology. 102: 1217-1223. PMID 3457014  0.64
1986 Anzano MA, Roberts AB, Sporn MB. Anchorage-independent growth of primary rat embryo cells is induced by platelet-derived growth factor and inhibited by type-beta transforming growth factor Journal of Cellular Physiology. 126: 312-318. PMID 3455929  0.64
1986 Stern DF, Roberts AB, Roche NS, Sporn MB, Weinberg RA. Differential responsiveness of myc- and ras-transfected cells to growth factors: Selective stimulation of myc-transfected cells by epidermal growth factor Molecular and Cellular Biology. 6: 870-877. PMID 3022135 DOI: 10.1128/MCB.6.3.870  0.64
1986 Fanger BO, Wakefield LM, Sporn MB. Structure and properties of the cellular receptor for transforming growth factor type β Biochemistry. 25: 3083-3091. PMID 2873833  0.64
1986 Fanger BO, Sporn MB. A binding assay for the solubilized receptors of type beta transforming growth factor: Adsorption and removal of free ligand by dextran-coated charcoal Analytical Biochemistry. 156: 444-453. PMID 2429585 DOI: 10.1016/0003-2697(86)90278-2  0.64
1986 Roberts AB, Sporn MB, Assoian RK. Transforming growth factor type β: Rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro Proceedings of the National Academy of Sciences of the United States of America. 83: 4167-4171. PMID 2424019  0.64
1985 Sporn MB, Roberts AB. Autocrine, paracrine and endocrine mechanisms of growth control Cancer Surveys. 4: 627-632. PMID 3939685  0.64
1985 Sporn MB, Roberts AB. Suppression of carcinogenesis by retinoids: interactions with peptide growth factors and their receptors as a key mechanism Princess Takamatsu Symposia. 16: 149-158. PMID 3916193  0.64
1985 Sporn MB, Roberts AB. What is a retinoid? Ciba Foundation Symposium. 113: 1-5. PMID 3896696  0.64
1985 Sporn MB, Roberts AB. Autocrine growth factors and cancer Nature. 313: 745-747. PMID 3883191 DOI: 10.1038/313745a0  0.64
1985 Smith JM, Sporn MB, Roberts AB, Derynck R, Winkler ME, Gregory H. Human transforming growth factor-alpha causes precocious eyelid opening in newborn mice. Nature. 315: 515-6. PMID 3873618 DOI: 10.1038/315515a0  0.64
1985 Knowles MA, Hicks RM, Dave H, Harvey AE, Roberts AB, Sporn MB. Transforming growth factors induce markers of neoplasia in cultured adult rat bladder. Carcinogenesis. 6: 595-604. PMID 3872740 DOI: 10.1093/carcin/6.4.595  0.64
1985 Derynck R, Jarrett JA, Chen EY, Eaton DH, Bell JR, Assoian RK, Roberts AB, Sporn MB, Goeddel DV. Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells. Nature. 316: 701-5. PMID 3861940 DOI: 10.1038/316701a0  0.64
1985 Anzano MA, Roberts AB, De Larco JE, Wakefield LM, Assoian RK, Roche NS, Smith JM, Lazarus JE, Sporn MB. Increased secretion of type beta transforming growth factor accompanies viral transformation of cells. Molecular and Cellular Biology. 5: 242-7. PMID 3856735 DOI: 10.1128/MCB.5.1.242  0.32
1985 Dart LL, Smith DM, Meyers CA, Sporn MB, Frolik CA. Transforming growth factors from a human tumor cell: Characterization of transforming growth factor β and identification of high molecular weight transforming growth factor α Biochemistry. 24: 5925-5931. PMID 3002426 DOI: 10.1021/bi00342a035  0.64
1985 Roberts AB, Roche NS, Sporn MB. Selective inhibition of the anchorage-independent growth of myc-transfected fibroblasts by retinoic acid Nature. 315: 237-239. PMID 2987698 DOI: 10.1038/315237a0  0.64
1985 Roberts AB, Sporn MB. Transforming growth factors Cancer Surveys. 4: 683-705. PMID 2890434  0.64
1985 Fanger BO, Wakefield LM, Sporn MB. Properties and actions of type β transforming growth factor (TGF-β) receptors Federation Proceedings. 44.  0.64
1985 Anzano MA, Roberts AB, Sporn MB. Anchorage-independent growth of primary rat embryo cells is induced by platelet-derived growth factor and inhibited by type-β transforming growth factor Federation Proceedings. 44.  0.64
1984 Assoian RK, Grotendorst GR, Miller DM, Sporn MB. Cellular transformation by coordinated action of three peptide growth factors from human platelets Nature. 309: 804-806. PMID 6330562 DOI: 10.1038/309804a0  0.64
1984 Frolik CA, Wakefield LM, Smith DM, Sporn MB. Characterization of a membrane receptor for transforming growth factor-β in normal rat kidney fibroblasts Journal of Biological Chemistry. 259: 10995-11000. PMID 6088525  0.64
1984 Assoian RK, Sporn MB. New growth factors from human platelets acting through EGF receptor Federation Proceedings. 43.  0.64
1984 Assoian RK, Grotendorst GR, Sporn MB. Three peptides from human platelets inducing anchorage independent growth Federation Proceedings. 43.  0.64
1983 Frolik CA, Dart LL, Meyers CA, Smith DM, Sporn MB. Purification and initial characterization of a type β transforming growth factor from human placenta Proceedings of the National Academy of Sciences of the United States of America. 80: 3676-3680. PMID 6602340 DOI: 10.1073/pnas.80.12.3676  0.64
1983 Sporn MB. Retinoids and suppression of carcinogenesis Hospital Practice. 18: 83-98. PMID 6413381  0.64
1983 Roberts AB, Frolik CA, Anzano MA, Sporn MB. Transforming growth factors from neoplastic and nonneoplastic tissues Federation Proceedings. 42: 2621-2626. PMID 6303865  0.64
1983 Sporn MB. Role of Retinoids in Differentiation and Carcinogenesis Cancer Research. 43: 3034-3040. PMID 6189589 DOI: 10.1093/jnci/73.6.1381  0.64
1983 Bradshaw RA, Sporn MB. Polypeptide growth factors and the regulation of cell growth and differentiation. Introduction Federation Proceedings. 42: 2590-2591.  0.64
1982 Anzano MA, Roberts AB, Smith JM, Lamb LC, Sporn MB. Purification by reverse-phase high-performance liquid chromatography of an epidermal growth factor-dependent transforming growth factor. Analytical Biochemistry. 125: 217-24. PMID 6983313 DOI: 10.1016/0003-2697(82)90405-5  0.64
1982 Frolik CA, Dart LL, Sporn MB. Variables in the high-pressure cation-exchange chromatography of proteins Analytical Biochemistry. 125: 203-209. PMID 6816090 DOI: 10.1016/0003-2697(82)90403-1  0.64
1982 Roberts AB, Anzano MA, Lamb LC, Smith JM, Frolik CA, Marquardt H, Todaro GJ, Sporn MB. Isolation from murine sarcoma cells of novel transforming growth factors potentiated by EGF. Nature. 295: 417-9. PMID 6276769 DOI: 10.1038/295417a0  0.64
1982 Swanson BN, Newton DL, Roller PP, Sporn MB. Biotransformation and biological activity of N-(4-hydroxyphenyl)retinamide derivatives in rodents Journal of Pharmacology and Experimental Therapeutics. 219: 632-637. PMID 6170750  0.64
1981 Frolik CA, Dart LL, Sporn MB. Metabolism of all-trans-retinyl acetate to retinoic acid in hamster tracheal organ culture Biochimica Et Biophysica Acta (Bba)/Lipids and Lipid Metabolism. 663: 329-335. PMID 7213770 DOI: 10.1016/0005-2760(81)90218-6  0.64
1981 Peto R, Doll R, Buckley JD, Sporn MB. Can dietary beta-carotene materially reduce human cancer rates? Nature. 290: 201-208. PMID 7010181 DOI: 10.1038/290201a0  0.64
1981 Roberts AB, Anzano MA, Lamb LC, Smith JM, Sporn MB. New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues. Proceedings of the National Academy of Sciences of the United States of America. 78: 5339-43. PMID 6975480  0.64
1981 Frolik CA, Swanson BN, Dart LL, Sporn MB. Metabolism of 13-cis-retinoic acid: Identification of 13-cis-retinoyl-and 13-cis-4-oxoretinoyl-β-glucuronides in the bile of vitamin A-normal rats Archives of Biochemistry and Biophysics. 208: 344-352. PMID 6942787 DOI: 10.1016/0003-9861(81)90518-X  0.64
1981 Todaro GJ, De Larco JE, Fryling C, Johnson PA, Sporn MB. Transforming growth factors (TGFs): properties and possible mechanisms of action. Journal of Supramolecular Structure and Cellular Biochemistry. 15: 287-301. PMID 6267317 DOI: 10.1002/jsscb.1981.380150306  0.64
1981 Sporn MB, Harris ED. Proliferative Diseases The American Journal of Medicine. 70: 1231-1236. PMID 6263092 DOI: 10.1016/0002-9343(81)90832-9  0.64
1980 Sporn MB. Combination chemoprevention of cancer Nature. 287: 107-108. PMID 7432445  0.64
1980 Sporn MB, Todaro GJ. Autocrine secretion and malignant transformation of cells. The New England Journal of Medicine. 303: 878-80. PMID 7412807 DOI: 10.1056/NEJM198010093031511  0.64
1980 Acton N, Brossi A, Newton DL, Sporn MB. Potential prophylactic antitumor activity of retinylidene 1,3-diketones Journal of Medicinal Chemistry. 23: 805-809. PMID 7401108  0.64
1980 Roberts AB, Lamb LC, Sporn MB. Metabolism of all-trans-retinoic acid in hamster liver microsomes: oxidation of 4-hydroxy- to 4-keto-retinoic acid. Archives of Biochemistry and Biophysics. 199: 374-83. PMID 7362233 DOI: 10.1016/0003-9861(80)90293-3  0.64
1980 Frolik CA, Roller PP, Roberts AB, Sporn MB. In vitro and in vivo metabolism of all-trans- and 13-cis-retinoic acid in hamsters. Identification of 13-cis-4-oxoretinoic acid Journal of Biological Chemistry. 255: 8057-8062. PMID 6931830  0.64
1980 Roberts AB, Lamb LC, Newton DL, Sporn MB, De Larco JE, Todaro GJ. Transforming growth factors: isolation of polypeptides from virally and chemically transformed cells by acid/ethanol extraction. Proceedings of the National Academy of Sciences of the United States of America. 77: 3494-8. PMID 6251462 DOI: 10.1073/pnas.77.6.3494  0.64
1980 Newton DL, Henderson WR, Sporn MB. Structure-Activity Relationships of Retinoids in Hamster Tracheal Organ Culture Cancer Research. 40: 3413-3425. PMID 6159964  0.64
1980 Swanson BN, Zaharevitz DW, Sporn MB. Pharmacokinetics of N-(4-hydroxyphenyl)-all-trans-retinamide in rats Drug Metabolism and Disposition. 8: 168-172. PMID 6104581  0.64
1979 Sporn MB, Newton DL. Chemoprevention of cancer with retinoids Federation Proceedings. 38: 2528-2534. PMID 488376  0.64
1979 Roberts AB, Frolik CA, Nichols MD, Sporn MB. Retinoid-dependent induction of the in vivo and in vitro metabolism of retinoic acid in tissues of the vitamin A-deficient hamster Journal of Biological Chemistry. 254: 6303-6309. PMID 447714  0.64
1979 Roberts AB, Nichols MD, Newton DL, Sporn MB. In vitro metabolism of retinoic acid in hamster intestine and liver Journal of Biological Chemistry. 254: 6296-6302. PMID 447713  0.64
1979 Sporn MB. Retinoids and cancer prevention Ca-a Cancer Journal For Clinicians. 29: 120-125. PMID 108002  0.64
1979 Roberts AB, Lamb LC, Sporn MB. Retinoic acid metabolism in hamster liver microsomes Federation Proceedings. 38.  0.64
1979 Swanson BN, Zaharevitz DW, Frolik CA, Sporn MB. Disposition of N-(4-hydroxyphenyl)-all-trans-retinamide in rats Federation Proceedings. 38.  0.64
1979 Newton DL, Smith JM, Phillips SL, Sporn MB. 4-propionoxyphenyl retinamide, a new retinoid for studies of prevention of cancer in experimental animals Proceedings of the American Association For Cancer Research 0.64
1978 Frolik CA, Tavela TE, Peck GL, Sporn MB. High-pressure liquid chromatographic determination of 13-cis-retinoic acid and all-trans-retinoic acid in human plasma Analytical Biochemistry. 86: 743-750. PMID 655427 DOI: 10.1016/0003-2697(78)90802-3  0.64
1978 Frolik CA, Tavela TE, Sporn MB. Separation of the natural retinoids by high-pressure liquid chromatography Journal of Lipid Research. 19: 32-37. PMID 621439  0.64
1978 Frolik CA, Tavela TE, Newton DL, Sporn MB. In vitro metabolism and biological activity of all-trans-retinoic acid and its metabolites in hamster trachea Journal of Biological Chemistry. 253: 7319-7324. PMID 568139  0.64
1978 Stinson SF, Squire RA, Sporn MB. Pathology of Esophageal Neoplasms and Associated Proliferative Lesions Induced in Rats by N-Methyl-N-benzylnitrosamine Journal of the National Cancer Institute. 61: 1471-1475. PMID 281554 DOI: 10.1093/jnci/61.6.1471  0.64
1978 Todaro GJ, De Larco JE, Sporn MB. Retinoids block phenotypic cell transformation produced by sarcoma growth factor Nature. 276: 272-274. PMID 213728 DOI: 10.1038/276272a0  0.64
1978 Sporn MB. Chemoprevention of cancer Nature. 272: 402-403.  0.64
1978 Stinson SF, Sporn MB. Pathogenesis of tracheal carcinoma induced by N-methyl-N-nitrosourea (NMU) in hamsters Proceedings of the American Association For Cancer Research 0.64
1978 Roberts AB, Nichols MD, Sporn MB. In vitro metabolism of [11,12-3H]-retinoic acid by intestinal mucosa of vitamin A-deficient hamsters Federation Proceedings. 37: No. 2605.  0.64
1978 Becci PJ, Grubbs CJ, Moon RC, Sporn MB. Induction of transitional cell carcinomas (TCC) with N-butyl-(4-hydroxybutyl)nitrosamine (OH-BBN) in female rats Proceedings of the American Association For Cancer Research 0.64
1977 Moon RC, Grubbs CJ, Sporn MB, Goodman DG. Retinyl acetate inhibits mammary carcinogenesis induced by N-methyl-N-nitrosourea [16] Nature. 267: 620-621. PMID 876383 DOI: 10.1038/267620a0  0.64
1977 Sporn MB. Retinoids and carcinogenesis Nutrition Reviews. 35: 65-69. PMID 854240  0.64
1977 Sporn MB. Vitamin A and its analogs (retinoids) in cancer prevention Current Concepts in Nutrition. 6: 119-130. PMID 604014  0.64
1977 Reese DH, Friedman RD, Sporn MB. Induction of Hyperplasia and Its Suppression by Hydrocortisone in Organ-cultured Rat Urinary Bladder Cancer Research. 37: 1421--1427.. PMID 558048  0.64
1977 Grubbs CJ, Moon RC, Sporn MB, Newton DL. Inhibition of Mammary Cancer by Retinyl Methyl Ether Cancer Research. 37: 599-602. PMID 401683  0.64
1977 Stinson SF, Sporn MB. Use of an automated image analyser to quantitate cellular hyperplasia in urinary bladder epithelium Journal of Microscopy. 109: 329-335. PMID 328890 DOI: 10.1111/j.1365-2818.1977.tb01146.x  0.64
1977 Stinson SF, Smith JM, Sporn MB. Induction of esophageal carcinoma with N methyl N benzyl nitrosamine (MBZN) in the rat Proceedings of the American Association For Cancer Research 0.64
1977 Frolik CA, Tavela TE, Sporn MB. In vitro metabolism of retinoic acid by hamster trachea Federation Proceedings. 36.  0.64
1977 Grubbs CJ, Moon RC, Sporn MB, Goodman DC. Suppression of NMU induced mammary cancer by vitamin A acetate Proceedings of the American Association For Cancer Research 0.64
1976 Sporn MB. Approaches to Prevention of Epithelial Cancer during the Preneoplastic Period Cancer Research. 36: 2699-2702. PMID 1277177  0.64
1976 Reese DH, Friedman RD, Smith JM, Sporn MB. Organ Culture of Normal and Carcinogen-treated Rat Bladder Cancer Research. 36: 2525-2527. PMID 1277161  0.64
1976 Sporn MB, Dunlop NM, Newton DL, Henderson WR. Relationships between structure and activity of retinoids Nature. 263: 110-113. PMID 987541 DOI: 10.1038/263110a0  0.64
1976 Sporn MB, Dunlop NM, Newton DL, Smith JM. Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids) Federation Proceedings. 35: 1332-1338. PMID 770206  0.64
1976 Grubbs CJ, Moon RC, Sporn MB. Suppression of DMBA induced mammary tumorigenesis by retinyl methyl ether Proceedings of the American Association For Cancer Research 0.64
1975 Clamon GH, Sporn MB, Smith JM, Henderson WR. Effect of α retinyl acetate on growth of hamsters fed vitamin A deficient diets Journal of Nutrition. 105: 215-219. PMID 1117337  0.64
1975 Port CD, Sporn MB, Kaufman DG. Prevention of lung cancer in hamsters by 13 CIS retinoic acid Proceedings of the American Association For Cancer Research. 16.  0.64
1974 Clamon GH, Sporn MB, Smith JM, Saffiotti U. α and β-Retinyl acetate reverse metaplasias of vitamin A deficiency in hamster trachea in organ culture Nature. 250: 64-66. PMID 4841587 DOI: 10.1038/250064a0  0.64
1974 Ransford GH, Glinski RP, Sporn MB. 2' O ethyl pyrimidine nucleosides J.Carbohydr.Nucleos.Nucleot.. 1: 275-278.  0.64
1973 Glinski RP, Khan MS, Kalamas RL, Sporn MB. Nucleotide synthesis. IV. Phosphorylated 3′-amino-3′-deoxythymidine and 5′-amino-5′-deoxythymidine and derivatives Journal of Organic Chemistry. 38: 4299-4305. PMID 4778125  0.64
1973 Sporn MB, Dunlop NM, Yuspa SH. Retinyl acetate: effect on cellular content of RNA in epidermis in cell culture in chemically defined medium Science. 182: 722-723. PMID 4752212  0.64
1973 Harris CC, Kaufman DG, Sporn MB, Saffiotti U. Histogenesis of squamous metaplasia and squamous cell carcinoma of the respiratory epithelium in an animal model Cancer Chemother.Rep.. 4. PMID 4729337  0.64
1972 Molloy GR, Sporn MB, Kelley DE, Perry RP. Localization of polyadenylic acid sequences in messenger ribonucleic acid of mammalian cells Biochemistry. 11: 3256-3260. PMID 5065478  0.64
1972 Glinski RP, Sporn MB. Nucleotide synthesis. Derivatives of thymidine containing m- and p-haloacetamidophenyl phosphate groups Biochemistry. 11: 405-413. PMID 5059120  0.64
1972 Al-Arif A, Sporn MB. An analytical method for the separation of sugar-methylated ribonucleosides from base-methylated and nonmethylated ribonucleosides Analytical Biochemistry. 48: 386-393. PMID 4341766 DOI: 10.1016/0003-2697(72)90091-7  0.64
1972 al-Arif A, Sporn MB. 2'-O-methylation of adenosine, guanosine, uridine, and cytidine in RNA of isolated rat liver nuclei Proceedings of the National Academy of Sciences of the United States of America. 69: 1716-1719. PMID 4340155  0.64
1972 Gallo RC, Schrecker AW, Sporn MB. Inhibition of RNA-dependent DNA Polymerase by Thymidylate Derivatives Cancer Research. 32: 1547-1553. PMID 4113116  0.64
1971 Glinski RP, Ash AB, Stevens CL, Sporn M, Lazarus HM. Nucleotide synthesis. I. Derivatives of thymidine containing p-nitrophenyl phosphate groups. The Journal of Organic Chemistry. 36: 245-9. PMID 5545351 DOI: 10.1021/jo00801a001  0.64
1971 Lazarus HM, Sporn MB. Studies on the allosteric properties of nuclear exoribonuclease from ehrlich ascites tumor Biochemistry. 10: 505-510. PMID 5101340  0.64
1971 Sporn MB. Studies on the effects of chemicals on the processing of nuclear RNA. Some possible implications with respect to carcinogenesis Biochemical Pharmacology. 20: 1029-1033. PMID 4258298 DOI: 10.1016/0006-2952(71)90330-3  0.64
1970 Glinski RP, Sami Khan M, Kalamas RL, Stevens CL, Sporn MB. The synthesis of phosphorylated 3′-amino-3′-deoxythymidine and 5′-amino-5′-deoxythymidine Journal of the Chemical Society D: Chemical Communications. 915-916. DOI: 10.1039/C29700000915  0.64
1969 Sporn MB, Berkowitz DM, Glinski RP, Ash A, Stevens CL. Irreversible inhibition of nuclear exoribonuclease by thymidine-3'-fluorophosphate and p-haloacetamidophenyl nucleotides. Science (New York, N.Y.). 164: 1408-10. PMID 5814684 DOI: 10.1126/science.164.3886.1408  0.64
1969 Sporn MB, Lazarus HM, Smith JM, Henderson WR. Studies on nuclear exoribonucleases. III. Isolation and properties of the enzyme from normal and malignant tissues of the mouse Biochemistry. 8: 1698-1706. PMID 5805304 DOI: 10.1021/bi00832a053  0.64
1968 Lazarus HM, Sporn MB, Bradley DF. A new kinetic model for polynucleotide metabolism Proceedings of the National Academy of Sciences of the United States of America. 60: 1503-1510. PMID 5244756  0.64
1967 Dingman CW, Sporn MB. The Binding of Metabolites of Aminoazo Dyes to Rat Liver DNA in Vivo Cancer Research. 27: 938-944. PMID 6025257  0.64
1967 Lazarus HM, Sporn MB, Smith JM, Henderson WR. Purification of T antigen from nuclei of simian virus 40-induced hamster tumors Journal of Virology. 1: 1093-1095. PMID 4316234  0.64
1966 Sporn MB, Dingman CW. 2-Acetamidofluorene and 3-methylcholanthrene: Differences in binding to rat liver deoxyribonucleic acid in vivo [26] Nature. 210: 531-532. PMID 5960519 DOI: 10.1038/210531a0  0.64
1966 Sporn MB, Wesley Dingman C, Phelps HL, Wogan GN. Aflatoxin Bi: Binding to DNA in vitro and alteration of RNA metabolism in vivo Science. 151: 1539-1541. PMID 5909585 DOI: 10.1126/science.151.3717.1539  0.64
1966 Sporn MB, Dingman CW. Studies on Chromatin II. Effects of Carcinogens and Hormones on Rat Liver Chromatin Cancer Research. 26: 2488-2495. PMID 4959456  0.64
1965 Dingman CW, Sporn MB. Actinomycin D and hydrocortisone: Intracellular binding in rat liver Science. 149: 1251-1254. PMID 5827723  0.64
1964 DINGMAN CW, SPORN MB. STUDIES ON CHROMATIN. I. ISOLATION AND CHARACTERIZATION OF NUCLEAR The Journal of Biological Chemistry. 239: 3483-3492. PMID 14245406  0.64
1964 Dingman W, Sporn MB. Molecular theories of memory Science. 144: 26-29. PMID 14107458  0.64
1963 Sporn MB, Dingman W. The fractionation and characterization of nuclear ribonucleic acid from rat liver Bba - Biochimica Et Biophysica Acta. 68: 389-400. PMID 13990241  0.64
1963 Sporn MB, Wesley Dingman C. Histone and DNA in isolated nuclei from chicken brain, liver, and erythrocytes Science. 140: 316-318. PMID 13990239  0.64
1962 SPORN MB, WANKO T, DINGMAN W. The isolation of cell nuclei from rat brain The Journal of Cell Biology. 15: 109-120. PMID 13990240  0.64
1962 BARONDES SH, DINGMAN CW, SPORN MB. In vitro stimulation of amino-acid incorporation into protein by liver nuclear RNA. Nature. 196: 145-7. PMID 13969459 DOI: 10.1038/196145a0  0.64
1962 Dingman W, Sporn MB. The isolation and physical characterization of nuclear and microsomal ribonucleic acid from rat brain and liver Bba Specialized Section On Nucleic Acids and Related Subjects. 61: 164-177. PMID 13886495  0.64
1961 Dingman W, Sporn MB. The incorporation of 8-azaguanine into rat brain RNA and its effect on maze-learning by the rat: An inquiry into the biochemical basis of memory Journal of Psychiatric Research. 1: 1-11. PMID 13886494  0.64
1959 Sporn MB, Dingman W, Defalco A, Davies RK. THE SYNTHESIS OF UREA IN THE LIVING RAT BRAIN Journal of Neurochemistry. 5: 62-67. PMID 13833443 DOI: 10.1111/j.1471-4159.1959.tb13333.x  0.64
1959 Sporn MB, Dingman W, Defalco A, Davies RK. Formation of urea from arginine in the brain of the living rat Nature. 183: 1520-1521. PMID 13666795 DOI: 10.1038/1831520a0  0.64
1959 Dingman W, Sporn MB, Davies RK. THE CHEMICAL FRACTIONATION OF RAT BRAIN PROTEINS Journal of Neurochemistry. 4: 154-160. PMID 13665377 DOI: 10.1111/j.1471-4159.1959.tb13185.x  0.64
1959 Dingman W, Sporn MB. THE PENETRATION OF PROLINE AND PROLINE DERIVATIVES INTO BRAIN Journal of Neurochemistry. 4: 148-153. PMID 13665376 DOI: 10.1111/j.1471-4159.1959.tb13184.x  0.64
1959 Sporn MB, Dingman W, Defalco A. A METHOD FOR STUDYING METABOLIC PATHWAYS IN THE BRAIN OF THE INTACT ANIMAL: THE CONVERSION OF PROLINE TO OTHER AMINO ACIDS Journal of Neurochemistry. 4: 141-147. PMID 13665375 DOI: 10.1111/j.1471-4159.1959.tb13183.x  0.64
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