| Year |
Citation |
Score |
| 2019 |
Jonsson P, Lin AL, Young RJ, DiStefano NM, Hyman DM, Li BT, Berger MF, Zehir A, Ladanyi M, Solit DB, Arnold AG, Stadler ZK, Mandelker D, Goldberg ME, Chmielecki J, et al. Genomic correlates of disease progression and treatment response in prospectively characterized gliomas. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31263031 DOI: 10.1158/1078-0432.CCR-19-0032 |
0.32 |
|
| 2017 |
Parachoniak CA, Rankin A, Gaffney B, Hartmaier R, Spritz D, Erlich RL, Miller VA, Morosini D, Stephens P, Ross JS, Keech J, Chmielecki J. Exceptional Durable Response to Everolimus in a Patient with Biphenotypic Breast Cancer Harboring an STK11 Variant. Cold Spring Harbor Molecular Case Studies. PMID 28550065 DOI: 10.1101/mcs.a000778 |
0.32 |
|
| 2017 |
Chalmers ZR, Connelly CF, Fabrizio D, Gay L, Ali SM, Ennis R, Schrock A, Campbell B, Shlien A, Chmielecki J, Huang F, He Y, Sun J, Tabori U, Kennedy M, et al. Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden. Genome Medicine. 9: 34. PMID 28420421 DOI: 10.1186/s13073-017-0424-2 |
0.32 |
|
| 2017 |
Hartmaier RJ, Charo J, Fabrizio D, Goldberg ME, Albacker LA, Pao W, Chmielecki J. Genomic analysis of 63,220 tumors reveals insights into tumor uniqueness and targeted cancer immunotherapy strategies. Genome Medicine. 9: 16. PMID 28231819 DOI: 10.1186/s13073-017-0408-2 |
0.92 |
|
| 2017 |
Chmielecki J, Bailey M, He J, Elvin J, Vergilio JA, Ramkissoon S, Suh J, Frampton GM, Sun JX, Morley S, Spritz D, Ali S, Gay L, Erlich RL, Ross JS, et al. Genomic Profiling of a Large Set of Diverse Pediatric Cancers Identifies Known and Novel Mutations across Tumor Spectra. Cancer Research. PMID 28069802 DOI: 10.1158/0008-5472.CAN-16-1106 |
0.32 |
|
| 2016 |
Meletath SK, Pavlick D, Brennan T, Hamilton R, Chmielecki J, Elvin JA, Palma N, Ross JS, Miller VA, Stephens PJ, Snipes G, Rajaram V, Ali SM, Melguizo-Gavilanes I. Personalized Treatment for a Patient With a BRAF V600E Mutation Using Dabrafenib and a Tumor Treatment Fields Device in a High-Grade Glioma Arising From Ganglioglioma. Journal of the National Comprehensive Cancer Network : Jnccn. 14: 1345-1350. PMID 27799506 |
0.32 |
|
| 2016 |
Ross JS, Gay LM, Wang K, Ali SM, Chumsri S, Elvin JA, Bose R, Vergilio JA, Suh J, Yelensky R, Lipson D, Chmielecki J, Waintraub S, Leyland-Jones B, Miller VA, et al. Nonamplification ERBB2 genomic alterations in 5605 cases of recurrent and metastatic breast cancer: An emerging opportunity for anti-HER2 targeted therapies. Cancer. PMID 27284958 DOI: 10.1002/cncr.30102 |
0.92 |
|
| 2016 |
Ali SM, Hensing T, Schrock AB, Allen J, Sanford E, Gowen K, Kulkarni A, He J, Suh JH, Lipson D, Elvin JA, Yelensky R, Chalmers Z, Chmielecki J, Peled N, et al. Comprehensive Genomic Profiling Identifies a Subset of Crizotinib-Responsive ALK-Rearranged Non-Small Cell Lung Cancer Not Detected by Fluorescence In Situ Hybridization. The Oncologist. PMID 27245569 DOI: 10.1634/theoncologist.2015-0497 |
0.92 |
|
| 2016 |
Heilmann AM, Subbiah V, Wang K, Sun JX, Elvin JA, Chmielecki J, Sherman SI, Murthy R, Busaidy NL, Subbiah I, Yelensky R, Nangia C, Vergilio JA, Khan SA, Erlich RL, et al. Comprehensive Genomic Profiling of Clinically Advanced Medullary Thyroid Carcinoma. Oncology. PMID 27207748 DOI: 10.1159/000445978 |
0.92 |
|
| 2016 |
Suh JH, Johnson A, Albacker L, Wang K, Chmielecki J, Frampton G, Gay L, Elvin JA, Vergilio JA, Ali S, Miller VA, Stephens PJ, Ross JS. Comprehensive Genomic Profiling Facilitates Implementation of the National Comprehensive Cancer Network Guidelines for Lung Cancer Biomarker Testing and Identifies Patients Who May Benefit From Enrollment in Mechanism-Driven Clinical Trials. The Oncologist. PMID 27151654 DOI: 10.1634/theoncologist.2016-0030 |
0.92 |
|
| 2016 |
Chung JH, Sanford E, Johnson A, Klempner SJ, Schrock AB, Palma NA, Erlich RL, Frampton GM, Chalmers ZR, Vergilio J, Rubinson DA, Sun JX, Chmielecki J, Yelensky R, Suh JH, et al. Comprehensive Genomic Profiling of Anal Squamous Cell Carcinoma Reveals Distinct Genomically Defined Classes. Annals of Oncology : Official Journal of the European Society For Medical Oncology / Esmo. PMID 27052656 DOI: 10.1093/annonc/mdw152 |
0.92 |
|
| 2016 |
Foster SA, Whalen DM, Özen A, Wongchenko MJ, Yin J, Yen I, Schaefer G, Mayfield JD, Chmielecki J, Stephens PJ, Albacker LA, Yan Y, Song K, Hatzivassiliou G, Eigenbrot C, et al. Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2. Cancer Cell. PMID 26996308 DOI: 10.1016/j.ccell.2016.02.010 |
0.92 |
|
| 2016 |
Schrock AB, Frampton GM, Herndon D, Greenbowe J, Wang K, Lipson D, Yelensky R, Chalmers Z, Chmielecki J, Elvin JA, Wollner M, Dvir A, Soussan-Guttman L, Bordonii R, Peled N, et al. Comprehensive Genomic Profiling Identifies Frequent Drug Sensitive EGFR Exon 19 Deletions in NSCLC Not Identified by Prior Molecular Testing. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 26933124 DOI: 10.1158/1078-0432.CCR-15-1668 |
0.92 |
|
| 2015 |
Ali SM, Pal SK, Wang K, Palma NA, Sanford E, Bailey M, He J, Elvin JA, Chmielecki J, Squillace R, Dow E, Morosini D, Buell J, Yelensky R, Lipson D, et al. Comprehensive Genomic Profiling of Advanced Penile Carcinoma Suggests a High Frequency of Clinically Relevant Genomic Alterations. The Oncologist. PMID 26670666 DOI: 10.1634/theoncologist.2015-0241 |
0.92 |
|
| 2015 |
Williams CB, McMahon C, Ali SM, Abramovitz M, Williams KA, Klein J, McKean H, Yelensky R, George TJ, Elvin JA, Soman S, Lipson D, Chmielecki J, Morosini D, Miller VA, et al. A metastatic colon adenocarcinoma harboring BRAF V600E has a durable major response to dabrafenib/trametinib and chemotherapy. Oncotargets and Therapy. 8: 3561-3564. PMID 26664139 DOI: 10.2147/OTT.S90766 |
0.92 |
|
| 2015 |
Ross JS, Ali SM, Wang K, Khaira D, Palma NA, Chmielecki J, Palmer GA, Morosini D, Elvin JA, Fernandez SV, Miller VA, Stephens PJ, Cristofanilli M. Comprehensive genomic profiling of inflammatory breast cancer cases reveals a high frequency of clinically relevant genomic alterations. Breast Cancer Research and Treatment. PMID 26458824 DOI: 10.1007/s10549-015-3592-z |
0.92 |
|
| 2015 |
Wang K, Johnson A, Ali SM, Klempner SJ, Bekaii-Saab T, Vacirca JL, Khaira D, Yelensky R, Chmielecki J, Elvin JA, Lipson D, Miller VA, Stephens PJ, Ross JS. Comprehensive Genomic Profiling of Advanced Esophageal Squamous Cell Carcinomas and Esophageal Adenocarcinomas Reveals Similarities and Differences. The Oncologist. PMID 26336083 DOI: 10.1634/theoncologist.2015-0156 |
0.92 |
|
| 2015 |
Ross JS, Wang K, Chmielecki J, Gay L, Johnson A, Chudnovsky J, Yelensky R, Lipson D, Ali SM, Elvin JA, Vergilio JA, Roels S, Miller VA, Nakamura BN, Gray A, et al. The distribution of BRAF gene fusions in solid tumors and response to targeted therapy. International Journal of Cancer. Journal International Du Cancer. PMID 26314551 DOI: 10.1002/ijc.29825 |
0.92 |
|
| 2015 |
Disel U, Germain A, Yilmazel B, Abali H, Bolat FA, Yelensky R, Elvin JA, Lipson D, Chmielecki J, Wang K, Stephens PJ, Ross JS, Miller VA, Ali SM, George TJ. Durable clinical benefit to trastuzumab and chemotherapy in a patient with metastatic colon adenocarcinoma harboring ERBB2 amplification. Oncoscience. 2: 581-4. PMID 26244165 DOI: 10.18632/oncoscience.175 |
0.92 |
|
| 2015 |
Klempner SJ, Bazhenova LA, Braiteh FS, Nikolinakos PG, Gowen K, Cervantes CM, Chmielecki J, Greenbowe JR, Ross JS, Stephens PJ, Miller VA, Ali SM, Ou SH. Emergence of RET rearrangement co-existing with activated EGFR mutation in EGFR-mutated NSCLC patients who had progressed on first- or second-generation EGFR TKI. Lung Cancer (Amsterdam, Netherlands). 89: 357-9. PMID 26187428 DOI: 10.1016/j.lungcan.2015.06.021 |
0.92 |
|
| 2015 |
Ross JS, Wang K, Gay L, Otto GA, White E, Iwanik K, Palmer G, Yelensky R, Lipson DM, Chmielecki J, Erlich RL, Rankin AN, Ali SM, Elvin JA, Morosini D, et al. Comprehensive Genomic Profiling of Carcinoma of Unknown Primary Site: New Routes to Targeted Therapies. Jama Oncology. 1: 40-9. PMID 26182302 DOI: 10.1001/jamaoncol.2014.216 |
0.92 |
|
| 2015 |
Crago AM, Chmielecki J, Rosenberg M, O'Connor R, Byrne C, Wilder FG, Thorn K, Agius P, Kuk D, Socci ND, Qin LX, Meyerson M, Hameed M, Singer S. Near universal detection of alterations in CTNNB1 and Wnt pathway regulators in desmoid-type fibromatosis by whole-exome sequencing and genomic analysis. Genes, Chromosomes & Cancer. PMID 26171757 DOI: 10.1002/gcc.22272 |
0.92 |
|
| 2015 |
Pal SK, Choueiri TK, Wang K, Khaira D, Karam JA, Van Allen E, Palma NA, Stein MN, Johnson A, Squillace R, Elvin JA, Chmielecki J, Yelensky R, Yakirevich E, Lipson D, et al. Characterization of Clinical Cases of Collecting Duct Carcinoma of the Kidney Assessed by Comprehensive Genomic Profiling. European Urology. PMID 26149668 DOI: 10.1016/j.eururo.2015.06.019 |
0.92 |
|
| 2015 |
Subbiah V, McMahon C, Patel S, Zinner R, Silva EG, Elvin JA, Subbiah IM, Ohaji C, Ganeshan DM, Anand D, Levenback CF, Berry J, Brennan T, Chmielecki J, Chalmers ZR, et al. STUMP un"stumped": anti-tumor response to anaplastic lymphoma kinase (ALK) inhibitor based targeted therapy in uterine inflammatory myofibroblastic tumor with myxoid features harboring DCTN1-ALK fusion. Journal of Hematology & Oncology. 8: 66. PMID 26062823 DOI: 10.1186/s13045-015-0160-2 |
0.92 |
|
| 2015 |
Frampton GM, Ali SM, Rosenzweig M, Chmielecki J, Lu X, Bauer TM, Akimov M, Bufill JA, Lee C, Jentz D, Hoover R, Ou SI, Salgia R, Brennan T, Chalmers ZR, et al. Activation of MET via Diverse Exon 14 Splicing Alterations Occurs in Multiple Tumor Types and Confers Clinical Sensitivity to MET Inhibitors. Cancer Discovery. PMID 25971938 DOI: 10.1158/2159-8290.CD-15-0285 |
0.92 |
|
| 2015 |
Ali SM, Sanford EM, Klempner SJ, Rubinson DA, Wang K, Palma NA, Chmielecki J, Yelensky R, Palmer GA, Morosini D, Lipson D, Catenacci DV, Braiteh F, Erlich R, Stephens PJ, et al. Prospective comprehensive genomic profiling of advanced gastric carcinoma cases reveals frequent clinically relevant genomic alterations and new routes for targeted therapies. The Oncologist. 20: 499-507. PMID 25882375 DOI: 10.1634/theoncologist.2014-0378 |
0.92 |
|
| 2015 |
Chalmers ZR, Ali SM, Ohgami RS, Campregher PV, Frampton GM, Yelensky R, Elvin JA, Palma NA, Erlich R, Vergilio JA, Chmielecki J, Ross JS, Stephens PJ, Hermann R, Miller VA, et al. Comprehensive genomic profiling identifies a novel TNKS2-PDGFRA fusion that defines a myeloid neoplasm with eosinophilia that responded dramatically to imatinib therapy. Blood Cancer Journal. 5: e278. PMID 25658984 DOI: 10.1038/bcj.2014.95 |
0.92 |
|
| 2015 |
Guo G, Chmielecki J, Goparaju C, Heguy A, Dolgalev I, Carbone M, Seepo S, Meyerson M, Pass HI. Whole-exome sequencing reveals frequent genetic alterations in BAP1, NF2, CDKN2A, and CUL1 in malignant pleural mesothelioma. Cancer Research. 75: 264-9. PMID 25488749 DOI: 10.1158/0008-5472.CAN-14-1008 |
0.92 |
|
| 2015 |
Chmielecki J, Ross JS, Wang K, Frampton GM, Palmer GA, Ali SM, Palma N, Morosini D, Miller VA, Yelensky R, Lipson D, Stephens PJ. Oncogenic alterations in ERBB2/HER2 represent potential therapeutic targets across tumors from diverse anatomic sites of origin. The Oncologist. 20: 7-12. PMID 25480824 DOI: 10.1634/theoncologist.2014-0234 |
0.92 |
|
| 2014 |
Zheng Z, Liebers M, Zhelyazkova B, Cao Y, Panditi D, Lynch KD, Chen J, Robinson HE, Shim HS, Chmielecki J, Pao W, Engelman JA, Iafrate AJ, Le LP. Anchored multiplex PCR for targeted next-generation sequencing. Nature Medicine. 20: 1479-84. PMID 25384085 DOI: 10.1038/nm.3729 |
0.92 |
|
| 2014 |
Chmielecki J, Hutchinson KE, Frampton GM, Chalmers ZR, Johnson A, Shi C, Elvin J, Ali SM, Ross JS, Basturk O, Balasubramanian S, Lipson D, Yelensky R, Pao W, Miller VA, et al. Comprehensive genomic profiling of pancreatic acinar cell carcinomas identifies recurrent RAF fusions and frequent inactivation of DNA repair genes. Cancer Discovery. 4: 1398-405. PMID 25266736 DOI: 10.1158/2159-8290.CD-14-0617 |
0.92 |
|
| 2014 |
. Comprehensive molecular profiling of lung adenocarcinoma. Nature. 511: 543-50. PMID 25079552 DOI: 10.1038/nature13385 |
0.92 |
|
| 2014 |
Ross JS, Wang K, Rand JV, Gay L, Presta MJ, Sheehan CE, Ali SM, Elvin JA, Labrecque E, Hiemstra C, Buell J, Otto GA, Yelensky R, Lipson D, Morosini D, ... Chmielecki J, et al. Next-generation sequencing of adrenocortical carcinoma reveals new routes to targeted therapies. Journal of Clinical Pathology. 67: 968-73. PMID 25078331 DOI: 10.1136/jclinpath-2014-202514 |
0.92 |
|
| 2014 |
Sharman JP, Chmielecki J, Morosini D, Palmer GA, Ross JS, Stephens PJ, Stafl J, Miller VA, Ali SM. Vemurafenib response in 2 patients with posttransplant refractory BRAF V600E-mutated multiple myeloma. Clinical Lymphoma, Myeloma & Leukemia. 14: e161-3. PMID 24997557 DOI: 10.1016/j.clml.2014.06.004 |
0.92 |
|
| 2014 |
Ross JS, Wang K, Elkadi OR, Tarasen A, Foulke L, Sheehan CE, Otto GA, Palmer G, Yelensky R, Lipson D, Chmielecki J, Ali SM, Elvin J, Morosini D, Miller VA, et al. Next-generation sequencing reveals frequent consistent genomic alterations in small cell undifferentiated lung cancer. Journal of Clinical Pathology. 67: 772-6. PMID 24978188 DOI: 10.1136/jclinpath-2014-202447 |
0.92 |
|
| 2014 |
Brooks AN, Choi PS, de Waal L, Sharifnia T, Imielinski M, Saksena G, Pedamallu CS, Sivachenko A, Rosenberg M, Chmielecki J, Lawrence MS, DeLuca DS, Getz G, Meyerson M. A pan-cancer analysis of transcriptome changes associated with somatic mutations in U2AF1 reveals commonly altered splicing events. Plos One. 9: e87361. PMID 24498085 DOI: 10.1371/journal.pone.0087361 |
0.92 |
|
| 2014 |
Chmielecki J, Meyerson M. DNA sequencing of cancer: what have we learned? Annual Review of Medicine. 65: 63-79. PMID 24274178 DOI: 10.1146/annurev-med-060712-200152 |
0.92 |
|
| 2013 |
Chmielecki J, Crago AM, Rosenberg M, O'Connor R, Walker SR, Ambrogio L, Auclair D, McKenna A, Heinrich MC, Frank DA, Meyerson M. Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors. Nature Genetics. 45: 131-2. PMID 23313954 DOI: 10.1038/ng.2522 |
0.92 |
|
| 2012 |
Foo J, Chmielecki J, Pao W, Michor F. Effects of pharmacokinetic processes and varied dosing schedules on the dynamics of acquired resistance to erlotinib in EGFR-mutant lung cancer. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. 7: 1583-93. PMID 22982659 DOI: 10.1097/JTO.0b013e31826146ee |
0.92 |
|
| 2012 |
Ohashi K, Sequist LV, Arcila ME, Moran T, Chmielecki J, Lin YL, Pan Y, Wang L, de Stanchina E, Shien K, Aoe K, Toyooka S, Kiura K, Fernandez-Cuesta L, Fidias P, et al. Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1. Proceedings of the National Academy of Sciences of the United States of America. 109: E2127-33. PMID 22773810 DOI: 10.1073/pnas.1203530109 |
0.92 |
|
| 2012 |
Chmielecki J, Pietanza MC, Aftab D, Shen R, Zhao Z, Chen X, Hutchinson K, Viale A, Kris MG, Stout T, Miller V, Rizvi N, Pao W. EGFR-mutant lung adenocarcinomas treated first-line with the novel EGFR inhibitor, XL647, can subsequently retain moderate sensitivity to erlotinib. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. 7: 434-42. PMID 22173702 DOI: 10.1097/JTO.0b013e31823c5aee |
0.92 |
|
| 2012 |
Chmielecki J, Peifer M, Viale A, Hutchinson K, Giltnane J, Socci ND, Hollis CJ, Dean RS, Yenamandra A, Jagasia M, Kim AS, Davé UP, Thomas RK, Pao W. Systematic screen for tyrosine kinase rearrangements identifies a novel C6orf204-PDGFRB fusion in a patient with recurrent T-ALL and an associated myeloproliferative neoplasm. Genes, Chromosomes & Cancer. 51: 54-65. PMID 21938754 DOI: 10.1002/gcc.20930 |
0.92 |
|
| 2011 |
Oxnard GR, Arcila ME, Chmielecki J, Ladanyi M, Miller VA, Pao W. New strategies in overcoming acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in lung cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 5530-7. PMID 21775534 DOI: 10.1158/1078-0432.CCR-10-2571 |
0.92 |
|
| 2011 |
Chmielecki J, Foo J, Oxnard GR, Hutchinson K, Ohashi K, Somwar R, Wang L, Amato KR, Arcila M, Sos ML, Socci ND, Viale A, de Stanchina E, Ginsberg MS, Thomas RK, et al. Optimization of dosing for EGFR-mutant non-small cell lung cancer with evolutionary cancer modeling. Science Translational Medicine. 3: 90ra59. PMID 21734175 DOI: 10.1126/scitranslmed.3002356 |
0.92 |
|
| 2011 |
Oxnard GR, Arcila ME, Sima CS, Riely GJ, Chmielecki J, Kris MG, Pao W, Ladanyi M, Miller VA. Acquired resistance to EGFR tyrosine kinase inhibitors in EGFR-mutant lung cancer: distinct natural history of patients with tumors harboring the T790M mutation. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 1616-22. PMID 21135146 DOI: 10.1158/1078-0432.CCR-10-2692 |
0.92 |
|
| 2010 |
Chmielecki J, Pao W. Highly active antitumor therapy (HAATT) for epidermal growth factor receptor-mutant lung cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 5371-3. PMID 21062927 DOI: 10.1158/1078-0432.CCR-10-2405 |
0.92 |
|
| 2010 |
Pao W, Chmielecki J. Rational, biologically based treatment of EGFR-mutant non-small-cell lung cancer. Nature Reviews. Cancer. 10: 760-74. PMID 20966921 DOI: 10.1038/nrc2947 |
0.92 |
|
| 2010 |
Chmielecki J, Peifer M, Jia P, Socci ND, Hutchinson K, Viale A, Zhao Z, Thomas RK, Pao W. Targeted next-generation sequencing of DNA regions proximal to a conserved GXGXXG signaling motif enables systematic discovery of tyrosine kinase fusions in cancer. Nucleic Acids Research. 38: 6985-96. PMID 20587502 DOI: 10.1093/nar/gkq579 |
0.92 |
|
| 2009 |
Roovers K, Wagner S, Storbeck CJ, O'Reilly P, Lo V, Northey JJ, Chmielecki J, Muller WJ, Siegel PM, Sabourin LA. The Ste20-like kinase SLK is required for ErbB2-driven breast cancer cell motility. Oncogene. 28: 2839-48. PMID 19525980 DOI: 10.1038/onc.2009.146 |
0.92 |
|
| 2009 |
Veeriah S, Brennan C, Meng S, Singh B, Fagin JA, Solit DB, Paty PB, Rohle D, Vivanco I, Chmielecki J, Pao W, Ladanyi M, Gerald WL, Liau L, Cloughesy TC, et al. The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers. Proceedings of the National Academy of Sciences of the United States of America. 106: 9435-40. PMID 19478061 DOI: 10.1073/pnas.0900571106 |
0.92 |
|
| 2008 |
Northey JJ, Chmielecki J, Ngan E, Russo C, Annis MG, Muller WJ, Siegel PM. Signaling through ShcA is required for transforming growth factor beta- and Neu/ErbB-2-induced breast cancer cell motility and invasion. Molecular and Cellular Biology. 28: 3162-76. PMID 18332126 DOI: 10.1128/MCB.01734-07 |
0.92 |
|
| 2007 |
Gong Y, Somwar R, Politi K, Balak M, Chmielecki J, Jiang X, Pao W. Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas. Plos Medicine. 4: e294. PMID 17927446 DOI: 10.1371/journal.pmed.0040294 |
0.92 |
|
| Low-probability matches |
| 2018 |
Hartmaier RJ, Trabucco SE, Priedigkeit N, Chung JH, Parachoniak CA, Vanden Borre P, Morley S, Rosenzweig M, Gay LM, Goldberg ME, Suh J, Ali S, Ross J, Leyland-Jones B, Young B, ... ... Chmielecki J, et al. Recurrent hyperactive ESR1 fusion proteins in endocrine therapy resistant breast cancer. Annals of Oncology : Official Journal of the European Society For Medical Oncology. PMID 29360925 DOI: 10.1093/annonc/mdy025 |
0.12 |
|
| 2017 |
Wang L, Basturk O, Wang J, Benayed R, Middha S, Zehir A, Linkov I, Rao M, Aryeequaye R, Cao L, Chmielecki J, Ross J, Stephens PJ, Adsay V, Askan G, et al. A FISH assay efficiently screens for BRAF gene rearrangements in pancreatic acinar-type neoplasms. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. PMID 28884748 DOI: 10.1038/modpathol.2017.106 |
0.12 |
|
| 2017 |
Hartmaier RJ, Albacker L, Chmielecki J, Bailey M, He J, Goldberg M, Ramkissoon S, Suh J, Elvin JA, Chiacchia S, Frampton GM, Ross JS, Miller V, Stephens PJ, Lipson D. High-throughput genomic profiling of adult solid tumors reveals novel insights into cancer pathogenesis. Cancer Research. PMID 28235761 DOI: 10.1158/0008-5472.CAN-16-2479 |
0.12 |
|
| 2016 |
Shi E, Chmielecki J, Tang CM, Wang K, Heinrich MC, Kang G, Corless CL, Hong D, Fero KE, Murphy JD, Fanta PT, Ali SM, De Siena M, Burgoyne AM, Movva S, et al. FGFR1 and NTRK3 actionable alterations in "Wild-Type" gastrointestinal stromal tumors. Journal of Translational Medicine. 14: 339. PMID 27974047 DOI: 10.1186/s12967-016-1075-6 |
0.12 |
|
| 2017 |
Albacker LA, Wu J, Smith P, Warmuth M, Stephens PJ, Zhu P, Yu L, Chmielecki J. Loss of function JAK1 mutations occur at high frequency in cancers with microsatellite instability and are suggestive of immune evasion. Plos One. 12: e0176181. PMID 29121062 DOI: 10.1371/journal.pone.0176181 |
0.08 |
|
| 2017 |
Bieg-Bourne CC, Millis SZ, Piccioni DE, Fanta PT, Goldberg ME, Chmielecki J, Parker BA, Kurzrock R. Next-generation sequencing in the clinical setting clarifies patient characteristics and potential actionability. Cancer Research. PMID 28939679 DOI: 10.1158/0008-5472.CAN-17-1569 |
0.08 |
|
| 2016 |
Priedigkeit N, Hartmaier RJ, Chen Y, Vareslija D, Basudan A, Watters RJ, Thomas R, Leone JP, Lucas PC, Bhargava R, Hamilton RL, Chmielecki J, Puhalla SL, Davidson NE, Oesterreich S, et al. Intrinsic Subtype Switching and Acquired ERBB2/HER2 Amplifications and Mutations in Breast Cancer Brain Metastases. Jama Oncology. PMID 27926948 DOI: 10.1001/jamaoncol.2016.5630 |
0.08 |
|
| 2016 |
Goldstein LD, Lee J, Gnad F, Klijn C, Schaub A, Reeder J, Daemen A, Bakalarski CE, Holcomb T, Shames DS, Hartmaier RJ, Chmielecki J, Seshagiri S, Gentleman R, Stokoe D. Recurrent Loss of NFE2L2 Exon 2 Is a Mechanism for Nrf2 Pathway Activation in Human Cancers. Cell Reports. PMID 27568559 DOI: 10.1016/j.celrep.2016.08.010 |
0.08 |
|
| 2016 |
Tang CM, Lee TE, Syed SA, Burgoyne AM, Leonard SY, Gao F, Chan JC, Shi E, Chmielecki J, Morosini D, Wang K, Ross JS, Kendrick ML, Bardsley MR, De Siena M, et al. Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression. Oncotarget. PMID 27793025 DOI: 10.18632/oncotarget.12909 |
0.04 |
|
| 2021 |
Vaclova T, Grazini U, Ward L, O'Neill D, Markovets A, Huang X, Chmielecki J, Hartmaier R, Thress KS, Smith PD, Barrett JC, Downward J, de Bruin EC. Clinical impact of subclonal EGFR T790M mutations in advanced-stage EGFR-mutant non-small-cell lung cancers. Nature Communications. 12: 1780. PMID 33741979 DOI: 10.1038/s41467-021-22057-8 |
0.01 |
|
| 2020 |
Smith HW, Yang L, Ling C, Walsh A, Martinez VD, Boucher J, Zuo D, Sokol ES, Pavlick DC, Frampton GM, Chmielecki J, Jones LM, Roux PP, Lockwood WW, Muller WJ. An ErbB2 splice variant lacking exon 16 drives lung carcinoma. Proceedings of the National Academy of Sciences of the United States of America. PMID 32727899 DOI: 10.1073/pnas.2007474117 |
0.01 |
|
| 2019 |
Yang JCH, Kim SW, Kim DW, Lee JS, Cho BC, Ahn JS, Lee DH, Kim TM, Goldman JW, Natale RB, Brown AP, Collins B, Chmielecki J, Vishwanathan K, Mendoza-Naranjo A, et al. Osimertinib in Patients With Epidermal Growth Factor Receptor Mutation-Positive Non-Small-Cell Lung Cancer and Leptomeningeal Metastases: The BLOOM Study. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. JCO1900457. PMID 31809241 DOI: 10.1200/JCO.19.00457 |
0.01 |
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| 2019 |
Brown H, Vansteenkiste J, Nakagawa K, Cobo M, John T, Barker C, Kohlmann A, Todd A, Saggese M, Chmielecki J, Markovets A, Scott M, Ramalingam SS. Brief Report: Programmed Cell Death Ligand 1 Expression in Untreated EGFR Mutated Advanced Non-Small Cell Lung Cancer and Response to Osimertinib versus Comparator in FLAURA. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. PMID 31605792 DOI: 10.1016/j.jtho.2019.09.009 |
0.01 |
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| 2019 |
Zhou C, Imamura F, Cheng Y, Okamoto I, Cho BC, Lin MC, Majem M, Gautschi O, Gray JE, Boyer MJ, Chmielecki J, Hartmaier R, Bulusu K, Barrett JC, Hodge R, et al. Early clearance of plasma EGFR mutations as a predictor of response to osimertinib and comparator EGFR-TKIs in the FLAURA trial. Journal of Clinical Oncology. 37: 9020-9020. DOI: 10.1200/JCO.2019.37.15_SUPPL.9020 |
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| 2018 |
Papadimitrakopoulou VA, Wu YL, Han JY, Ahn MJ, Ramalingam SS, John T, Okamoto I, Yang JC, Bulusu KC, Laus G, Collins B, Barrett JC, Chmielecki J, Mok TSK. Analysis of resistance mechanisms to osimertinib in patients with EGFR T790M advanced NSCLC from the AURA3 study. Annals of Oncology : Official Journal of the European Society For Medical Oncology. 29: viii741. PMID 32138033 DOI: 10.1093/annonc/mdy424.064 |
0.01 |
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| 2018 |
Hong MH, Kim MH, Kim SY, Heo SG, Kang HN, Park CW, Barrett JC, Stetson D, Chmielecki J, Markovets A, Kim HR, Cho BC. Molecular landscape of osimertinib resistance revealed by targeted panel sequencing and patient-derived cancer models in non-small cell lung cancer patients. Annals of Oncology : Official Journal of the European Society For Medical Oncology. 29: viii516. PMID 32137338 DOI: 10.1093/annonc/mdy292.051 |
0.01 |
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| 2018 |
Du Z, Brewster R, Merrill PH, Chmielecki J, Francis J, Aizer A, Abedalthagafi M, Sholl LM, Geffers L, Alexander B, Santagata S. Meningioma transcription factors link cell lineage with systemic metabolic cues. Neuro-Oncology. PMID 29660031 DOI: 10.1093/neuonc/noy057 |
0.01 |
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| 2018 |
Charo LM, Burgoyne AM, Fanta PT, Patel H, Chmielecki J, Sicklick JK, McHale MT. A NovelFusion in Gastrointestinal Stromal Tumor Guides Adjuvant Treatment Decision-Making During Pregnancy. Journal of the National Comprehensive Cancer Network : Jnccn. 16: 238-242. PMID 29523662 DOI: 10.6004/jnccn.2017.7039 |
0.01 |
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| 2018 |
Oza A, Cibula D, Oaknin A, Poole C, Mathijssen R, Sonke G, Colombo N, Špaček J, Vuylsteke P, Hirte H, Pfisterer J, Plante M, Hanker L, Fielding A, Haddad V, ... Chmielecki J, et al. Olaparib maintenance therapy in patients (pts) with platinum-sensitive relapsed (PSR) ovarian cancer (OC) and stable disease (SD) following platinum-based chemotherapy Annals of Oncology. 29: viii340. DOI: 10.1093/annonc/mdy285.158 |
0.01 |
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| 2018 |
Piotrowska Z, Chmielecki J, Cripps D, Miranda M. P1.01-80 ELIOS: A Multicenter, Open-Label, Molecular Profiling Study of Patients with EGFRm and NSCLC Treated with Osimertinib Journal of Thoracic Oncology. 13: S493-S494. DOI: 10.1016/J.JTHO.2018.08.636 |
0.01 |
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| 2018 |
Brown H, Vansteenkiste J, Nakagawa K, Cobo Dols M, John T, Barker C, Kohlmann A, Todd A, Saggese M, Chmielecki J, Markovets A, Ramalingam S. MA15.03 PD-L1 Expression in Untreated EGFRm Advanced NSCLC and Response to Osimertinib and SoC EGFR-TKIs in the FLAURA Trial Journal of Thoracic Oncology. 13: S408. DOI: 10.1016/j.jtho.2018.08.441 |
0.01 |
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| 2017 |
Thress KS, Markovets A, Barrett JC, Chmielecki J, Goldberg SB, Shepherd FA, Vowler S, Oxnard GR. Complete clearance of plasma EGFR mutations as a predictor of outcome on osimertinib in the AURA trial. Journal of Clinical Oncology. 35: 9018-9018. DOI: 10.1200/JCO.2017.35.15_SUPPL.9018 |
0.01 |
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| 2016 |
Wang K, Russell JS, McDermott JD, Elvin JA, Khaira D, Johnson A, Jennings TA, Ali SM, Murray M, Marshall C, Oldham D, Washburn D, Wong S, Chmiekecki J, Yelensky R, et al. Profiling of 149 salivary duct carcinomas, carcinoma ex pleomorphic adenomas, and adenocarcinomas, not otherwise specified reveals actionable genomic alterations. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 27334835 DOI: 10.1158/1078-0432.CCR-15-2568 |
0.01 |
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| 2016 |
Elvin JA, Patterson C, Chalmers ZR, Ali SM, Brennan T, Chmielecki J, Stephens P, Boyle LE, Ross JS, Miller VA. Comprehensive genomic profiling (CGP) of advanced nonseminomatous testicular germ cell tumors (NSGCT) to reveal clinically relevant genomic alterations (CRGA) to guide targeted therapy. Journal of Clinical Oncology. 34: 477-477. DOI: 10.1200/jco.2016.34.2_suppl.477 |
0.01 |
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| 2016 |
Chmielecki J. How Data Exchange Can Help Advance the Promise of Precision Medicine Oncology Times. 38: 21. DOI: 10.1097/01.cot.0000494634.19302.7b |
0.01 |
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| 2015 |
Li Y, Woo J, Chmielecki J, Xia CQ, Liao M, Chuang BC, Yang JJ, Guan MY, Plesescu M, Prakash SR. Synthesis of a new inhibitor of breast cancer resistance protein with significantly improved pharmacokinetic profiles. Bioorganic & Medicinal Chemistry Letters. PMID 26642765 DOI: 10.1016/j.bmcl.2015.11.077 |
0.01 |
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| 2015 |
Elvin JA, Bailey M, Carneiro BA, Ali SM, Vergilio J, Palma NA, Chmielecki J, Frampton GM, Lipson D, Stephens P, Miller VA, Johnson ML, Giles FJ, Ross JS, Dorigo O. Comprehensive genomic profiling (CGP) of cervical squamous cell carcinoma (cSCC) to identifiy targeted therapy options. Journal of Clinical Oncology. 33: 5602-5602. DOI: 10.1200/JCO.2015.33.15_SUPPL.5602 |
0.01 |
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| 2015 |
Massarweh SA, Chmielecki J, Sun J, Stewart RL, Dressler EVM, Kadamyan V, Chambers MD, Horbinski C, Mehdi M, Black EP, Romond EH. Effect of mutations in distinct components of the PI3K/AKT/mTOR pathway on sensitivity to endocrine therapy in estrogen receptor (ER)-positive breast cancer. Journal of Clinical Oncology. 33: 532-532. DOI: 10.1200/JCO.2015.33.15_SUPPL.532 |
0.01 |
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| 2015 |
Black EP, Romond EH, Chmielecki J, Sun J, Kadamyan V, Chambers MD, Stewart RL, Dressler EVM, Mehdi M, Horbinski C, Massarweh SA. Evaluation of possible linkage between everolimus benefit in estrogen receptor (ER)-positive breast cancer and genomic alterations of the PI3K/AKT/mTOR pathway. Journal of Clinical Oncology. 33: 530-530. DOI: 10.1200/jco.2015.33.15_suppl.530 |
0.01 |
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| 2015 |
Hawryluk MJ, Wang K, Ali SM, Fisher H, Mian B, Nazeer T, Elvin JA, Chmielecki J, Yelensky R, Lipson D, Miller VA, Stephens PJ, Ross JS. Comprehensive genomic profiling of 295 cases of clinically advanced urothelial carcinoma of the urinary bladder to reveal frequency of clinically relevant genomic alterations. Journal of Clinical Oncology. 33: 4526-4526. DOI: 10.1200/jco.2015.33.15_suppl.4526 |
0.01 |
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| 2015 |
Ross JS, Wang K, Javle MM, Catenacci DVT, Shroff RT, Ali SM, Elvin JA, Chmielecki J, Yelensky R, Lipson D, Miller VA, Stephens PJ, Meric-Bernstam F. Comprehensive genomic profiling of biliary tract cancers to reveal tumor-specific differences and frequency of clinically relevant genomic alterations. Journal of Clinical Oncology. 33: 4009-4009. DOI: 10.1200/JCO.2015.33.15_SUPPL.4009 |
0.01 |
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| 2015 |
Ross JS, Wang K, Khaira D, Johnson A, Chmielecki J, Ali SM, Elvin JA, Vergilio J, Yelensky R, Lipson D, Miller VA, Stephens PJ. Comprehensive genomic profiling of clinically advanced colorectal carcinoma to reveal frequent opportunities for targeted therapies. Journal of Clinical Oncology. 33: 3553-3553. DOI: 10.1200/JCO.2015.33.15_SUPPL.3553 |
0.01 |
|
| 2015 |
Sanford EM, Ali SM, Elvin JA, Frampton GM, Sun J, Palma NA, Chmielecki J, Yelensky R, Lipson D, Miller VA, Stephens PJ, Ross JS. Comprehensive genomic profiling of anal squamous cell carcinoma to reveal frequency of clinically relevant genomic alterations in the PI3K/mTOR pathway. Journal of Clinical Oncology. 33: 3522-3522. DOI: 10.1200/JCO.2015.33.15_SUPPL.3522 |
0.01 |
|
| 2015 |
Chalmers ZR, Ali SM, Frampton GM, Chmielecki J, Palma NA, Elvin JA, Johnson A, Yelensky R, Ross JS, Stephens PJ, Miller VA, Waanders AJ, Crawford J. GE-04 * COMPREHENSIVE GENOMIC PROFILING (CGP) OF PEDIATRIC GLIOMAS REVEALS A HIGH FREQUENCY OF CLINICALLY RELEVANT GENOMIC ALTERATIONS (CRGA) ASSOCIATED WITH BENEFIT FROM TARGETED THERAPY Neuro-Oncology. 17: iii7-iii8. DOI: 10.1093/neuonc/nov061.28 |
0.01 |
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| 2015 |
Elvin J, Wang K, Ali S, Chmielecki J, Stephens P, Dorigo O, Ross J. Comprehensive genomic profiling of advanced stage endometrioid endometrial adenocarcinomas (EEAC) reveals differences associated with CTNNB1 mutation status and a high frequency of clinically relevant genomic alterations Gynecologic Oncology. 137: 65-66. DOI: 10.1016/j.ygyno.2015.01.154 |
0.01 |
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| 2014 |
Shern JF, Chen L, Chmielecki J, Wei JS, Patidar R, Rosenberg M, Ambrogio L, Auclair D, Wang J, Song YK, Tolman C, Hurd L, Liao H, Zhang S, Bogen D, et al. Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors. Cancer Discovery. 4: 216-31. PMID 24436047 DOI: 10.1158/2159-8290.CD-13-0639 |
0.01 |
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| 2014 |
Hawryluk MJ, Wang K, Chmielecki J, Ali SM, Palmer GA, Downing S, Curran J, Garcia L, White E, Lipson D, Yelensky R, Stephens PJ, Miller VA, Ross JS. Clinical application of comprehensive next-generation sequencing-based genomic profiling for identification of actionable genomic alterations in pediatric solid tumors and hematolymphoid malignancies: The Foundation Medicine pediatric experience. Journal of Clinical Oncology. 32: 10035-10035. DOI: 10.1200/jco.2014.32.15_suppl.10035 |
0.01 |
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| 2014 |
Wang K, Morosini D, Yelensky R, Palma N, Johnson A, Lipson D, Chmielecki J, Ali S, Ross JS, Stephens PJ, Miller V. Genomic Alterations of Histone Modification Genes Are Significantly Less Common in Non-Hodgkin Lymphomas of Adolescents and Young Adults Compared to Older Patients Blood. 124: 1684-1684. DOI: 10.1182/blood.V124.21.1684.1684 |
0.01 |
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| 2013 |
Placzek MS, Chmielecki JM, Houghton C, Calder A, Wiles C, Jones GB. Fluoroalkynylations of aryl halides under continuous-flow homogeneous catalysis Journal of Flow Chemistry. 3: 46-50. DOI: 10.1556/JFC-D-13-00004 |
0.01 |
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| 1992 |
Zawilski J, Majewski W, Chmielecki J. Evaluation of surgical results in lower limb atherosclerotic ischemia comparing men and women Polski Tygodnik Lekarski. 47: 395-397. PMID 1409050 |
0.01 |
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