Elisa Izaurralde - Publications

Affiliations: 
Biochemistry Max Planck Institut fuer Entwicklungsbiologie 

167 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Keskeny C, Raisch T, Sgromo A, Igreja C, Bhandari D, Weichenrieder O, Izaurralde E. A conserved CAF40-binding motif in metazoan NOT4 mediates association with the CCR4-NOT complex. Genes & Development. 33: 236-252. PMID 30692204 DOI: 10.1101/gad.320952.118  0.56
2018 Raisch T, Sandmeir F, Weichenrieder O, Valkov E, Izaurralde E. Structural and biochemical analysis of a NOT1 MIF4G-like domain of the CCR4-NOT complex. Journal of Structural Biology. PMID 30367941 DOI: 10.1016/j.jsb.2018.10.009  0.56
2017 Sgromo A, Raisch T, Backhaus C, Keskeny C, Alva V, Weichenrieder O, Izaurralde E. Drosophila Bag-of-marbles directly interacts with the CAF40 subunit of the CCR4-NOT complex to elicit repression of mRNA targets. Rna (New York, N.Y.). PMID 29255063 DOI: 10.1261/rna.064584.117  0.56
2017 Sgromo A, Raisch T, Bawankar P, Bhandari D, Chen Y, Kuzuoğlu-Öztürk D, Weichenrieder O, Izaurralde E. A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin. Nature Communications. 8: 14307. PMID 28165457 DOI: 10.1038/ncomms14307  0.56
2016 Grüner S, Peter D, Weber R, Wohlbold L, Chung MY, Weichenrieder O, Valkov E, Igreja C, Izaurralde E. The Structures of eIF4E-eIF4G Complexes Reveal an Extended Interface to Regulate Translation Initiation. Molecular Cell. PMID 27773676 DOI: 10.1016/j.molcel.2016.09.020  0.56
2016 Valkov E, Muthukumar S, Chang CT, Jonas S, Weichenrieder O, Izaurralde E. Structure of the Dcp2-Dcp1 mRNA-decapping complex in the activated conformation. Nature Structural & Molecular Biology. PMID 27183195 DOI: 10.1038/nsmb.3232  0.56
2016 Kuzuoğlu-Öztürk D, Bhandari D, Huntzinger E, Fauser M, Helms S, Izaurralde E. miRISC and the CCR4-NOT complex silence mRNA targets independently of 43S ribosomal scanning. The Embo Journal. PMID 27009120 DOI: 10.15252/embj.201592901  0.56
2016 Raisch T, Bhandari D, Sabath K, Helms S, Valkov E, Weichenrieder O, Izaurralde E. Distinct modes of recruitment of the CCR4-NOT complex by Drosophila and vertebrate Nanos. The Embo Journal. PMID 26968986 DOI: 10.15252/embj.201593634  0.56
2015 Peter D, Weber R, Köne C, Chung MY, Ebertsch L, Truffault V, Weichenrieder O, Igreja C, Izaurralde E. Mextli proteins use both canonical bipartite and novel tripartite binding modes to form eIF4E complexes that display differential sensitivity to 4E-BP regulation. Genes & Development. 29: 1835-49. PMID 26294658 DOI: 10.1101/gad.269068.115  0.56
2015 Izaurralde E. GENE REGULATION. Breakers and blockers—miRNAs at work. Science (New York, N.Y.). 349: 380-2. PMID 26206919 DOI: 10.1126/science.1260969  0.56
2015 Jonas S, Izaurralde E. Towards a molecular understanding of microRNA-mediated gene silencing. Nature Reviews. Genetics. 16: 421-33. PMID 26077373 DOI: 10.1038/nrg3965  0.56
2015 Peter D, Igreja C, Weber R, Wohlbold L, Weiler C, Ebertsch L, Weichenrieder O, Izaurralde E. Molecular architecture of 4E-BP translational inhibitors bound to eIF4E. Molecular Cell. 57: 1074-87. PMID 25702871 DOI: 10.1016/j.molcel.2015.01.017  0.56
2014 Igreja C, Peter D, Weiler C, Izaurralde E. 4E-BPs require non-canonical 4E-binding motifs and a lateral surface of eIF4E to repress translation. Nature Communications. 5: 4790. PMID 25179781 DOI: 10.1038/ncomms5790  0.52
2014 Jonas S, Christie M, Peter D, Bhandari D, Loh B, Huntzinger E, Weichenrieder O, Izaurralde E. An asymmetric PAN3 dimer recruits a single PAN2 exonuclease to mediate mRNA deadenylation and decay. Nature Structural & Molecular Biology. 21: 599-608. PMID 24880343 DOI: 10.1038/nsmb.2837  0.52
2014 Chen Y, Boland A, Kuzuoğlu-Öztürk D, Bawankar P, Loh B, Chang CT, Weichenrieder O, Izaurralde E. A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencing. Molecular Cell. 54: 737-50. PMID 24768540 DOI: 10.1016/j.molcel.2014.03.034  0.52
2014 Bhandari D, Raisch T, Weichenrieder O, Jonas S, Izaurralde E. Structural basis for the Nanos-mediated recruitment of the CCR4-NOT complex and translational repression. Genes & Development. 28: 888-901. PMID 24736845 DOI: 10.1101/gad.237289.113  0.52
2014 Chang CT, Bercovich N, Loh B, Jonas S, Izaurralde E. The activation of the decapping enzyme DCP2 by DCP1 occurs on the EDC4 scaffold and involves a conserved loop in DCP1. Nucleic Acids Research. 42: 5217-33. PMID 24510189 DOI: 10.1093/nar/gku129  0.52
2013 Jonas S, Izaurralde E. The role of disordered protein regions in the assembly of decapping complexes and RNP granules. Genes & Development. 27: 2628-41. PMID 24352420 DOI: 10.1101/gad.227843.113  0.52
2013 Boland A, Chen Y, Raisch T, Jonas S, Kuzuoğlu-Öztürk D, Wohlbold L, Weichenrieder O, Izaurralde E. Structure and assembly of the NOT module of the human CCR4-NOT complex. Nature Structural & Molecular Biology. 20: 1289-97. PMID 24121232 DOI: 10.1038/nsmb.2681  0.52
2013 Loh B, Jonas S, Izaurralde E. The SMG5-SMG7 heterodimer directly recruits the CCR4-NOT deadenylase complex to mRNAs containing nonsense codons via interaction with POP2. Genes & Development. 27: 2125-38. PMID 24115769 DOI: 10.1101/gad.226951.113  0.52
2013 Christie M, Boland A, Huntzinger E, Weichenrieder O, Izaurralde E. Structure of the PAN3 pseudokinase reveals the basis for interactions with the PAN2 deadenylase and the GW182 proteins. Molecular Cell. 51: 360-73. PMID 23932717 DOI: 10.1016/j.molcel.2013.07.011  0.52
2013 Nishihara T, Zekri L, Braun JE, Izaurralde E. miRISC recruits decapping factors to miRNA targets to enhance their degradation. Nucleic Acids Research. 41: 8692-705. PMID 23863838 DOI: 10.1093/nar/gkt619  0.52
2013 Hentze MW, Izaurralde E. Making sense of nonsense. Nature Structural & Molecular Biology. 20: 651-3. PMID 23739166 DOI: 10.1038/nsmb.2601  0.52
2013 Izaurralde E. A role for eIF4AII in microRNA-mediated mRNA silencing. Nature Structural & Molecular Biology. 20: 543-5. PMID 23649363 DOI: 10.1038/nsmb.2582  0.52
2013 Zekri L, Kuzuoğlu-Öztürk D, Izaurralde E. GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation. The Embo Journal. 32: 1052-65. PMID 23463101 DOI: 10.1038/emboj.2013.44  0.52
2013 Jonas S, Weichenrieder O, Izaurralde E. An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay. Genes & Development. 27: 211-25. PMID 23348841 DOI: 10.1101/gad.206672.112  0.52
2013 Bawankar P, Loh B, Wohlbold L, Schmidt S, Izaurralde E. NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain. Rna Biology. 10: 228-44. PMID 23303381 DOI: 10.4161/rna.23018  0.52
2013 Braun JE, Huntzinger E, Izaurralde E. The role of GW182 proteins in miRNA-mediated gene silencing. Advances in Experimental Medicine and Biology. 768: 147-63. PMID 23224969 DOI: 10.1007/978-1-4614-5107-5_9  0.52
2013 Huntzinger E, Kuzuoglu-Öztürk D, Braun JE, Eulalio A, Wohlbold L, Izaurralde E. The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets. Nucleic Acids Research. 41: 978-94. PMID 23172285 DOI: 10.1093/nar/gks1078  0.52
2012 Braun JE, Huntzinger E, Izaurralde E. A molecular link between miRISCs and deadenylases provides new insight into the mechanism of gene silencing by microRNAs. Cold Spring Harbor Perspectives in Biology. 4. PMID 23209154 DOI: 10.1101/cshperspect.a012328  0.52
2012 Braun JE, Truffault V, Boland A, Huntzinger E, Chang CT, Haas G, Weichenrieder O, Coles M, Izaurralde E. A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5' exonucleolytic degradation. Nature Structural & Molecular Biology. 19: 1324-31. PMID 23142987 DOI: 10.1038/nsmb.2413  0.52
2012 Petit AP, Wohlbold L, Bawankar P, Huntzinger E, Schmidt S, Izaurralde E, Weichenrieder O. The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex. Nucleic Acids Research. 40: 11058-72. PMID 22977175 DOI: 10.1093/nar/gks883  0.52
2012 Izaurralde E. Elucidating the temporal order of silencing. Embo Reports. 13: 662-3. PMID 22722480 DOI: 10.1038/embor.2012.91  0.52
2012 Kuzuoglu-Öztürk D, Huntzinger E, Schmidt S, Izaurralde E. The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes. Nucleic Acids Research. 40: 5651-65. PMID 22402495 DOI: 10.1093/nar/gks218  0.52
2012 Fromm SA, Truffault V, Kamenz J, Braun JE, Hoffmann NA, Izaurralde E, Sprangers R. The structural basis of Edc3- and Scd6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex. The Embo Journal. 31: 279-90. PMID 22085934 DOI: 10.1038/emboj.2011.408  0.52
2011 Braun JE, Huntzinger E, Fauser M, Izaurralde E. GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets. Molecular Cell. 44: 120-33. PMID 21981923 DOI: 10.1016/j.molcel.2011.09.007  0.52
2011 Igreja C, Izaurralde E. CUP promotes deadenylation and inhibits decapping of mRNA targets. Genes & Development. 25: 1955-67. PMID 21937713 DOI: 10.1101/gad.17136311  0.52
2011 Teplova M, Wohlbold L, Khin NW, Izaurralde E, Patel DJ. Structure-function studies of nucleocytoplasmic transport of retroviral genomic RNA by mRNA export factor TAP. Nature Structural & Molecular Biology. 18: 990-8. PMID 21822283 DOI: 10.1038/nsmb.2094  0.52
2011 Boland A, Huntzinger E, Schmidt S, Izaurralde E, Weichenrieder O. Crystal structure of the MID-PIWI lobe of a eukaryotic Argonaute protein. Proceedings of the National Academy of Sciences of the United States of America. 108: 10466-71. PMID 21646546 DOI: 10.1073/pnas.1103946108  0.52
2011 Huntzinger E, Izaurralde E. Gene silencing by microRNAs: contributions of translational repression and mRNA decay. Nature Reviews. Genetics. 12: 99-110. PMID 21245828 DOI: 10.1038/nrg2936  0.56
2010 Huntzinger E, Braun JE, Heimstädt S, Zekri L, Izaurralde E. Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing. The Embo Journal. 29: 4146-60. PMID 21063388 DOI: 10.1038/emboj.2010.274  0.56
2010 Kashima I, Jonas S, Jayachandran U, Buchwald G, Conti E, Lupas AN, Izaurralde E. SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay. Genes & Development. 24: 2440-50. PMID 20930030 DOI: 10.1101/gad.604610  0.56
2010 Braun JE, Tritschler F, Haas G, Igreja C, Truffault V, Weichenrieder O, Izaurralde E. The C-terminal alpha-alpha superhelix of Pat is required for mRNA decapping in metazoa. The Embo Journal. 29: 2368-80. PMID 20543818 DOI: 10.1038/emboj.2010.124  0.56
2010 Boland A, Tritschler F, Heimstädt S, Izaurralde E, Weichenrieder O. Crystal structure and ligand binding of the MID domain of a eukaryotic Argonaute protein. Embo Reports. 11: 522-7. PMID 20539312 DOI: 10.1038/embor.2010.81  0.56
2010 Haas G, Braun JE, Igreja C, Tritschler F, Nishihara T, Izaurralde E. HPat provides a link between deadenylation and decapping in metazoa. The Journal of Cell Biology. 189: 289-302. PMID 20404111 DOI: 10.1083/jcb.200910141  0.56
2010 Tritschler F, Huntzinger E, Izaurralde E. Role of GW182 proteins and PABPC1 in the miRNA pathway: a sense of déjà vu. Nature Reviews. Molecular Cell Biology. 11: 379-84. PMID 20379206 DOI: 10.1038/nrm2885  0.56
2009 Tritschler F, Braun JE, Motz C, Igreja C, Haas G, Truffault V, Izaurralde E, Weichenrieder O. DCP1 forms asymmetric trimers to assemble into active mRNA decapping complexes in metazoa. Proceedings of the National Academy of Sciences of the United States of America. 106: 21591-6. PMID 19966221 DOI: 10.1073/pnas.0909871106  0.56
2009 Zekri L, Huntzinger E, Heimstädt S, Izaurralde E. The silencing domain of GW182 interacts with PABPC1 to promote translational repression and degradation of microRNA targets and is required for target release. Molecular and Cellular Biology. 29: 6220-31. PMID 19797087 DOI: 10.1128/MCB.01081-09  0.56
2009 Izaurralde E. Freedom versus constraint in protein function. Nature Reviews. Molecular Cell Biology. 10: 372. PMID 19655438 DOI: 10.1038/nrm2697  0.56
2009 Hansen KD, Lareau LF, Blanchette M, Green RE, Meng Q, Rehwinkel J, Gallusser FL, Izaurralde E, Rio DC, Dudoit S, Brenner SE. Genome-wide identification of alternative splice forms down-regulated by nonsense-mediated mRNA decay in Drosophila. Plos Genetics. 5: e1000525. PMID 19543372 DOI: 10.1371/journal.pgen.1000525  0.56
2009 Eulalio A, Tritschler F, Izaurralde E. The GW182 protein family in animal cells: new insights into domains required for miRNA-mediated gene silencing. Rna (New York, N.Y.). 15: 1433-42. PMID 19535464 DOI: 10.1261/rna.1703809  0.56
2009 Izaurralde E, Zamore PD. Nucleus and gene expression. Current Opinion in Cell Biology. 21: 331-4. PMID 19447016 DOI: 10.1016/j.ceb.2009.04.013  0.56
2009 Wittkopp N, Huntzinger E, Weiler C, Saulière J, Schmidt S, Sonawane M, Izaurralde E. Nonsense-mediated mRNA decay effectors are essential for zebrafish embryonic development and survival. Molecular and Cellular Biology. 29: 3517-28. PMID 19414594 DOI: 10.1128/MCB.00177-09  0.56
2009 Eulalio A, Helms S, Fritzsch C, Fauser M, Izaurralde E. A C-terminal silencing domain in GW182 is essential for miRNA function. Rna (New York, N.Y.). 15: 1067-77. PMID 19383769 DOI: 10.1261/rna.1605509  0.56
2009 Lazzaretti D, Tournier I, Izaurralde E. The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins. Rna (New York, N.Y.). 15: 1059-66. PMID 19383768 DOI: 10.1261/rna.1606309  0.56
2009 Eulalio A, Tritschler F, Büttner R, Weichenrieder O, Izaurralde E, Truffault V. The RRM domain in GW182 proteins contributes to miRNA-mediated gene silencing. Nucleic Acids Research. 37: 2974-83. PMID 19295135 DOI: 10.1093/nar/gkp173  0.56
2009 Tritschler F, Braun JE, Eulalio A, Truffault V, Izaurralde E, Weichenrieder O. Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B. Molecular Cell. 33: 661-8. PMID 19285948 DOI: 10.1016/j.molcel.2009.02.014  0.56
2009 Eulalio A, Huntzinger E, Nishihara T, Rehwinkel J, Fauser M, Izaurralde E. Deadenylation is a widespread effect of miRNA regulation. Rna (New York, N.Y.). 15: 21-32. PMID 19029310 DOI: 10.1261/rna.1399509  0.56
2008 Huntzinger E, Kashima I, Fauser M, Saulière J, Izaurralde E. SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan. Rna (New York, N.Y.). 14: 2609-17. PMID 18974281 DOI: 10.1261/rna.1386208  0.56
2008 Tritschler F, Eulalio A, Helms S, Schmidt S, Coles M, Weichenrieder O, Izaurralde E, Truffault V. Similar modes of interaction enable Trailer Hitch and EDC3 to associate with DCP1 and Me31B in distinct protein complexes. Molecular and Cellular Biology. 28: 6695-708. PMID 18765641 DOI: 10.1128/MCB.00759-08  0.56
2008 Jinek M, Eulalio A, Lingel A, Helms S, Conti E, Izaurralde E. The C-terminal region of Ge-1 presents conserved structural features required for P-body localization. Rna (New York, N.Y.). 14: 1991-8. PMID 18755833 DOI: 10.1261/rna.1222908  0.56
2008 Eulalio A, Huntzinger E, Izaurralde E. GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay. Nature Structural & Molecular Biology. 15: 346-53. PMID 18345015 DOI: 10.1038/nsmb.1405  0.56
2008 Eulalio A, Huntzinger E, Izaurralde E. Getting to the root of miRNA-mediated gene silencing. Cell. 132: 9-14. PMID 18191211 DOI: 10.1016/j.cell.2007.12.024  0.56
2007 Tritschler F, Eulalio A, Truffault V, Hartmann MD, Helms S, Schmidt S, Coles M, Izaurralde E, Weichenrieder O. A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting. Molecular and Cellular Biology. 27: 8600-11. PMID 17923697 DOI: 10.1128/MCB.01506-07  0.56
2007 Eulalio A, Rehwinkel J, Stricker M, Huntzinger E, Yang SF, Doerks T, Dorner S, Bork P, Boutros M, Izaurralde E. Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing. Genes & Development. 21: 2558-70. PMID 17901217 DOI: 10.1101/gad.443107  0.56
2007 Dorner S, Eulalio A, Huntzinger E, Izaurralde E. Delving into the diversity of silencing pathways. Symposium on MicroRNAs and siRNAs: biological functions and mechanisms. Embo Reports. 8: 723-9. PMID 17599087 DOI: 10.1038/sj.embor.7401015  0.56
2007 Behm-Ansmant I, Kashima I, Rehwinkel J, Saulière J, Wittkopp N, Izaurralde E. mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons. Febs Letters. 581: 2845-53. PMID 17531985 DOI: 10.1016/j.febslet.2007.05.027  0.56
2007 Eulalio A, Behm-Ansmant I, Schweizer D, Izaurralde E. P-body formation is a consequence, not the cause, of RNA-mediated gene silencing. Molecular and Cellular Biology. 27: 3970-81. PMID 17403906 DOI: 10.1128/MCB.00128-07  0.56
2007 Behm-Ansmant I, Gatfield D, Rehwinkel J, Hilgers V, Izaurralde E. A conserved role for cytoplasmic poly(A)-binding protein 1 (PABPC1) in nonsense-mediated mRNA decay. The Embo Journal. 26: 1591-601. PMID 17318186 DOI: 10.1038/sj.emboj.7601588  0.56
2007 Eulalio A, Behm-Ansmant I, Izaurralde E. P bodies: at the crossroads of post-transcriptional pathways. Nature Reviews. Molecular Cell Biology. 8: 9-22. PMID 17183357 DOI: 10.1038/nrm2080  0.56
2006 Behm-Ansmant I, Rehwinkel J, Izaurralde E. MicroRNAs silence gene expression by repressing protein expression and/or by promoting mRNA decay Cold Spring Harbor Symposia On Quantitative Biology. 71: 523-530. PMID 17381335 DOI: 10.1101/sqb.2006.71.013  0.56
2006 Glavan F, Behm-Ansmant I, Izaurralde E, Conti E. Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex. The Embo Journal. 25: 5117-25. PMID 17053788 DOI: 10.1038/sj.emboj.7601377  0.56
2006 Rehwinkel J, Raes J, Izaurralde E. Nonsense-mediated mRNA decay: Target genes and functional diversification of effectors. Trends in Biochemical Sciences. 31: 639-46. PMID 17010613 DOI: 10.1016/j.tibs.2006.09.005  0.56
2006 Behm-Ansmant I, Rehwinkel J, Doerks T, Stark A, Bork P, Izaurralde E. mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes. Genes & Development. 20: 1885-98. PMID 16815998 DOI: 10.1101/gad.1424106  0.56
2006 Rehwinkel J, Natalin P, Stark A, Brennecke J, Cohen SM, Izaurralde E. Genome-wide analysis of mRNAs regulated by Drosha and Argonaute proteins in Drosophila melanogaster. Molecular and Cellular Biology. 26: 2965-75. PMID 16581772 DOI: 10.1128/MCB.26.8.2965-2975.2006  0.56
2006 Weigel D, Izaurralde E. A tiny helper lightens the maternal load. Cell. 124: 1117-8. PMID 16564001 DOI: 10.1016/j.cell.2006.03.005  0.56
2006 Behm-Ansmant I, Izaurralde E. Quality control of gene expression: a stepwise assembly pathway for the surveillance complex that triggers nonsense-mediated mRNA decay. Genes & Development. 20: 391-8. PMID 16481468 DOI: 10.1101/gad.1407606  0.56
2005 Lingel A, Simon B, Izaurralde E, Sattler M. The structure of the flock house virus B2 protein, a viral suppressor of RNA interference, shows a novel mode of double-stranded RNA recognition. Embo Reports. 6: 1149-55. PMID 16270100 DOI: 10.1038/sj.embor.7400583  0.56
2005 Rehwinkel J, Letunic I, Raes J, Bork P, Izaurralde E. Nonsense-mediated mRNA decay factors act in concert to regulate common mRNA targets. Rna (New York, N.Y.). 11: 1530-44. PMID 16199763 DOI: 10.1261/rna.2160905  0.56
2005 Rehwinkel J, Behm-Ansmant I, Gatfield D, Izaurralde E. A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing. Rna (New York, N.Y.). 11: 1640-7. PMID 16177138 DOI: 10.1261/rna.2191905  0.56
2005 Conti E, Izaurralde E. Nonsense-mediated mRNA decay: Molecular insights and mechanistic variations across species Current Opinion in Cell Biology. 17: 316-325. PMID 15901503 DOI: 10.1016/j.ceb.2005.04.005  0.56
2005 Fukuhara N, Ebert J, Unterholzner L, Lindner D, Izaurralde E, Conti E. SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway. Molecular Cell. 17: 537-47. PMID 15721257 DOI: 10.1016/j.molcel.2005.01.010  0.56
2005 Ciccarelli FD, von Mering C, Suyama M, Harrington ED, Izaurralde E, Bork P. Complex genomic rearrangements lead to novel primate gene function. Genome Research. 15: 343-51. PMID 15710750 DOI: 10.1101/gr.3266405  0.56
2005 Orban TI, Izaurralde E. Decay of mRNAs targeted by RISC requires XRN1, the Ski complex, and the exosome. Rna (New York, N.Y.). 11: 459-69. PMID 15703439 DOI: 10.1261/rna.7231505  0.56
2004 Unterholzner L, Izaurralde E. SMG7 acts as a molecular link between mRNA surveillance and mRNA decay. Molecular Cell. 16: 587-96. PMID 15546618 DOI: 10.1016/j.molcel.2004.10.013  0.56
2004 Lingel A, Izaurralde E. RNAi: finding the elusive endonuclease. Rna (New York, N.Y.). 10: 1675-9. PMID 15496518 DOI: 10.1261/rna.7175704  0.56
2004 Jínek M, Rehwinkel J, Lazarus BD, Izaurralde E, Hanover JA, Conti E. The superhelical TPR-repeat domain of O-linked GlcNAc transferase exhibits structural similarities to importin alpha. Nature Structural & Molecular Biology. 11: 1001-7. PMID 15361863 DOI: 10.1038/nsmb833  0.56
2004 Lingel A, Simon B, Izaurralde E, Sattler M. NMR assignment of the Drosophila Argonaute2 PAZ domain. Journal of Biomolecular Nmr. 29: 421-2. PMID 15213449 DOI: 10.1023/B:JNMR.0000032513.15693.04  0.56
2004 Gatfield D, Izaurralde E. Nonsense-mediated messenger RNA decay is initiated by endonucleolytic cleavage in Drosophila. Nature. 429: 575-8. PMID 15175755 DOI: 10.1038/nature02559  0.56
2004 Lingel A, Simon B, Izaurralde E, Sattler M. Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain. Nature Structural & Molecular Biology. 11: 576-7. PMID 15156196 DOI: 10.1038/nsmb777  0.56
2004 Rehwinkel J, Herold A, Gari K, Köcher T, Rode M, Ciccarelli FL, Wilm M, Izaurralde E. Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster. Nature Structural & Molecular Biology. 11: 558-66. PMID 15133499 DOI: 10.1038/nsmb759  0.56
2004 Kadlec J, Izaurralde E, Cusack S. The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3. Nature Structural & Molecular Biology. 11: 330-7. PMID 15004547 DOI: 10.1038/nsmb741  0.56
2004 Izaurralde E. Directing mRNA export. Nature Structural & Molecular Biology. 11: 210-2. PMID 14983170 DOI: 10.1038/nsmb0304-210  0.56
2004 Palacios IM, Gatfield D, St Johnston D, Izaurralde E. An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay. Nature. 427: 753-7. PMID 14973490 DOI: 10.1038/nature02351  0.56
2004 Bono F, Ebert J, Unterholzner L, Güttler T, Izaurralde E, Conti E. Molecular insights into the interaction of PYM with the Mago-Y14 core of the exon junction complex Embo Reports. 5: 304-310. PMID 14968132 DOI: 10.1038/sj.embor.7400091  0.56
2004 Forler D, Rabut G, Ciccarelli FD, Herold A, Köcher T, Niggeweg R, Bork P, Ellenberg J, Izaurralde E. RanBP2/Nup358 provides a major binding site for NXF1-p15 dimers at the nuclear pore complex and functions in nuclear mRNA export. Molecular and Cellular Biology. 24: 1155-67. PMID 14729961 DOI: 10.1128/MCB.24.3.1155-1167.2004  0.56
2004 Izaurralde E, Spector DL. Nucleus and gene expression: The interplay of transcriptional and post-transcriptional mechanisms that regulate gene expression Current Opinion in Cell Biology. 16: 219-222. DOI: 10.1016/j.ceb.2004.04.005  0.56
2003 Ciccarelli FD, Izaurralde E, Bork P. The PAM domain, a multi-protein complex-associated module with an all-alpha-helix fold. Bmc Bioinformatics. 4: 64. PMID 14687415 DOI: 10.1186/1471-2105-4-64  0.56
2003 Lingel A, Simon B, Izaurralde E, Sattler M. Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain. Nature. 426: 465-9. PMID 14615801 DOI: 10.1038/nature02123  0.56
2003 Gatfield D, Unterholzner L, Ciccarelli FD, Bork P, Izaurralde E. Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways. The Embo Journal. 22: 3960-70. PMID 12881430 DOI: 10.1093/emboj/cdg371  0.56
2003 Stutz F, Izaurralde E. The interplay of nuclear mRNP assembly, mRNA surveillance and export. Trends in Cell Biology. 13: 319-27. PMID 12791298 DOI: 10.1016/S0962-8924(03)00106-5  0.56
2003 Herold A, Teixeira L, Izaurralde E. Genome-wide analysis of nuclear mRNA export pathways in Drosophila. The Embo Journal. 22: 2472-83. PMID 12743041 DOI: 10.1093/emboj/cdg233  0.56
2003 Fribourg S, Gatfield D, Izaurralde E, Conti E. A novel mode of RBD-protein recognition in the Y14-Mago complex Nature Structural Biology. 10: 433-439. PMID 12730685 DOI: 10.1038/nsb926  0.56
2003 Forler D, Köcher T, Rode M, Gentzel M, Izaurralde E, Wilm M. An efficient protein complex purification method for functional proteomics in higher eukaryotes. Nature Biotechnology. 21: 89-92. PMID 12483225 DOI: 10.1038/nbt773  0.56
2002 Izaurralde E. A novel family of nuclear transport receptors mediates the export of messenger RNA to the cytoplasm. European Journal of Cell Biology. 81: 577-84. PMID 12498157 DOI: 10.1078/0171-9335-00273  0.56
2002 Gatfield D, Izaurralde E. REF1/Aly and the additional exon junction complex proteins are dispensable for nuclear mRNA export. The Journal of Cell Biology. 159: 579-88. PMID 12438415 DOI: 10.1083/jcb.200207128  0.56
2002 Braun IC, Herold A, Rode M, Izaurralde E. Nuclear export of mRNA by TAP/NXF1 requires two nucleoporin-binding sites but not p15. Molecular and Cellular Biology. 22: 5405-18. PMID 12101235 DOI: 10.1128/MCB.22.15.5405-5418.2002  0.56
2002 Izaurralde E. Nuclear export of messenger RNA. Results and Problems in Cell Differentiation. 35: 133-50. PMID 11791404  0.56
2001 Herold A, Klymenko T, Izaurralde E. NXF1/p15 heterodimers are essential for mRNA nuclear export in Drosophila. Rna (New York, N.Y.). 7: 1768-80. PMID 11780633  0.56
2001 Le Hir H, Gatfield D, Braun IC, Forler D, Izaurralde E. The protein Mago provides a link between splicing and mRNA localization Embo Reports. 2: 1119-1124. PMID 11743026 DOI: 10.1093/embo-reports/kve245  0.56
2001 Gatfield D, Le Hir H, Schmitt C, Braun IC, Köcher T, Wilm M, Izaurralde E. The DExH/D box protein HEL/UAP56 is essential for mRNA nuclear export in Drosophila Current Biology. 11: 1716-1721. PMID 11696332 DOI: 10.1016/S0960-9822(01)00532-2  0.56
2001 Koffa MD, Clements JB, Izaurralde E, Wadd S, Wilson SA, Mattaj IW, Kuersten S. Herpes simplex virus ICP27 protein provides viral mRNAs with access to the cellular mRNA export pathway. The Embo Journal. 20: 5769-78. PMID 11598019 DOI: 10.1093/emboj/20.20.5769  0.56
2001 Fribourg S, Braun IC, Izaurralde E, Conti E. Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor Molecular Cell. 8: 645-656. PMID 11583626 DOI: 10.1016/S1097-2765(01)00348-3  0.56
2001 Jun L, Frints S, Duhamel H, Herold A, Abad-Rodrigues J, Dotti C, Izaurralde E, Marynen P, Froyen G. NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation. Current Biology : Cb. 11: 1381-91. PMID 11566096 DOI: 10.1016/S0960-9822(01)00419-5  0.56
2001 Le Hir H, Gatfield D, Izaurralde E, Moore MJ. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay Embo Journal. 20: 4987-4997. PMID 11532962 DOI: 10.1093/emboj/20.17.4987  0.56
2001 Izaurralde E. A conserved family of nuclear export receptors mediates the exit of messenger RNA to the cytoplasm Cellular and Molecular Life Sciences. 58: 1105-1112. PMID 11529502  0.56
2001 Conti E, Izaurralde E. Nucleocytoplasmic transport enters the atomic age Current Opinion in Cell Biology. 13: 310-319. PMID 11343901 DOI: 10.1016/S0955-0674(00)00213-1  0.56
2001 Braun IC, Herold A, Rode M, Conti E, Izaurralde E. Overexpression of TAP/p15 heterodimers bypasses nuclear retention and stimulates nuclear mRNA export. The Journal of Biological Chemistry. 276: 20536-43. PMID 11259411 DOI: 10.1074/jbc.M100400200  0.56
2001 Rodrigues JP, Rode M, Gatfield D, Blencowe BJ, Carmo-Fonseca M, Izaurralde E. REF proteins mediate the export of spliced and unspliced mRNAs from the nucleus. Proceedings of the National Academy of Sciences of the United States of America. 98: 1030-5. PMID 11158589 DOI: 10.1073/pnas.031586198  0.56
2000 Hentze MW, Izaurralde E, Séraphin B. A new era for the RNA world - Conference: RNA 2000 Embo Reports. 1: 394-398. PMID 11258477  0.56
2000 Suyama M, Doerks T, Braun IC, Sattler M, Izaurralde E, Bork P. Prediction of structural domains of TAP reveals details of its interaction with p15 and nucleoporins. Embo Reports. 1: 53-8. PMID 11256625 DOI: 10.1038/sj.embor.embor627  0.56
2000 Le Hir H, Izaurralde E, Maquat LE, Moore MJ. The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions Embo Journal. 19: 6860-6869. PMID 11118221 DOI: 10.1093/emboj/19.24.6860  0.56
2000 von Kobbe C, van Deursen JM, Rodrigues JP, Sitterlin D, Bachi A, Wu X, Wilm M, Carmo-Fonseca M, Izaurralde E. Vesicular stomatitis virus matrix protein inhibits host cell gene expression by targeting the nucleoporin Nup98. Molecular Cell. 6: 1243-52. PMID 11106761  0.56
2000 Herold A, Suyama M, Rodrigues JP, Braun IC, Kutay U, Carmo-Fonseca M, Bork P, Izaurralde E. TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture. Molecular and Cellular Biology. 20: 8996-9008. PMID 11073998 DOI: 10.1128/MCB.20.23.8996-9008.2000  0.56
2000 Liker E, Fernandez E, Izaurralde E, Conti E. The structure of the mRNA export factor TAP reveals a cis arrangement of a non-canonical RNP domain and an LRR domain Embo Journal. 19: 5587-5598. PMID 11060011  0.56
2000 Paca RE, Ogert RA, Hibbert CS, Izaurralde E, Beemon KL. Rous sarcoma virus DR posttranscriptional elements use a novel RNA export pathway. Journal of Virology. 74: 9507-14. PMID 11000220 DOI: 10.1128/JVI.74.20.9507-9514.2000  0.56
2000 Stutz F, Bachi A, Doerks T, Braun IC, Séraphin B, Wilm M, Bork P, Izaurralde E. REF, an evolutionary conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export. Rna (New York, N.Y.). 6: 638-50. PMID 10786854  0.56
2000 Bachi A, Braun IC, Rodrigues JP, Panté N, Ribbeck K, von Kobbe C, Kutay U, Wilm M, Görlich D, Carmo-Fonseca M, Izaurralde E. The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates. Rna (New York, N.Y.). 6: 136-58. PMID 10668806 DOI: 10.1017/S1355838200991994  0.56
1999 Schmitt C, von Kobbe C, Bachi A, Panté N, Rodrigues JP, Boscheron C, Rigaut G, Wilm M, Séraphin B, Carmo-Fonseca M, Izaurralde E. Dbp5, a DEAD-box protein required for mRNA export, is recruited to the cytoplasmic fibrils of nuclear pore complex via a conserved interaction with CAN/Nup159p. The Embo Journal. 18: 4332-47. PMID 10428971 DOI: 10.1093/emboj/18.15.4332  0.56
1999 Paraskeva E, Izaurralde E, Bischoff FR, Huber J, Kutay U, Hartmann E, Lührmann R, Görlich D. CRM1-mediated recycling of snurportin 1 to the cytoplasm. The Journal of Cell Biology. 145: 255-64. PMID 10209022 DOI: 10.1083/jcb.145.2.255  0.56
1999 Braun IC, Rohrbach E, Schmitt C, Izaurralde E. TAP binds to the constitutive transport element (CTE) through a novel RNA-binding motif that is sufficient to promote CTE-dependent RNA export from the nucleus Embo Journal. 18: 1953-1965. PMID 10202158  0.56
1999 Lipowsky G, Bischoff FR, Izaurralde E, Kutay U, Schäfer S, Gross HJ, Beier H, Görlich D. Coordination of tRNA nuclear export with processing of tRNA. Rna (New York, N.Y.). 5: 539-49. PMID 10199570 DOI: 10.1017/S1355838299982134  0.56
1999 Izaurralde E, Kann M, Panté N, Sodeik B, Hohn T. Viruses, microorganisms and scientists meet the nuclear pore. Leysin, VD, Switzerland, February 26-March 1, 1998 The Embo Journal. 18: 289-296. PMID 9889185  0.52
1999 Izaurralde E, Kann M, Panté N, Sodeik B, Hohn T. EMBO Workshop, Leysin, VD, Switzerland, February 26-March 1 1998: Viruses, microorganisms and scientists meet the nuclear pore Embo Journal. 18: 289-296. DOI: 10.1093/emboj/18.2.289  0.56
1998 Grüter P, Tabernero C, von Kobbe C, Schmitt C, Saavedra C, Bachi A, Wilm M, Felber BK, Izaurralde E. TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus. Molecular Cell. 1: 649-59. PMID 9660949  0.56
1998 Kutay U, Lipowsky G, Izaurralde E, Bischoff FR, Schwarzmaier P, Hartmann E, Görlich D. Identification of a tRNA-specific nuclear export receptor. Molecular Cell. 1: 359-69. PMID 9660920  0.56
1998 Izaurralde E, Adam S. Transport of macromolecules between the nucleus and the cytoplasm Rna. 4: 351-364. PMID 9630243  0.56
1997 Izaurralde E, Kutay U, von Kobbe C, Mattaj IW, Görlich D. The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus. The Embo Journal. 16: 6535-47. PMID 9351834 DOI: 10.1093/emboj/16.21.6535  0.56
1997 Flaherty SM, Fortes P, Izaurralde E, Mattaj IW, Gilmartin GM. Participation of the nuclear cap binding complex in pre-mRNA 3' processing. Proceedings of the National Academy of Sciences of the United States of America. 94: 11893-8. PMID 9342333 DOI: 10.1073/pnas.94.22.11893  0.52
1997 Saavedra C, Felber B, Izaurralde E. The simian retrovirus-1 constitutive transport element, unlike the HIV-1 RRE, uses factors required for cellular mRNA export. Current Biology : Cb. 7: 619-28. PMID 9285715  0.56
1997 Lewis JD, Izaurralde E. The role of the cap structure in RNA processing and nuclear export European Journal of Biochemistry. 247: 461-469. PMID 9266685  0.56
1997 Görlich D, Dabrowski M, Bischoff FR, Kutay U, Bork P, Hartmann E, Prehn S, Izaurralde E. A novel class of RanGTP binding proteins. The Journal of Cell Biology. 138: 65-80. PMID 9214382 DOI: 10.1083/jcb.138.1.65  0.56
1997 Panté N, Jarmolowski A, Izaurralde E, Sauder U, Baschong W, Mattaj IW. Visualizing nuclear export of different classes of RNA by electron microscopy Rna. 3: 498-513. PMID 9149231  0.56
1997 Kutay U, Izaurralde E, Bischoff FR, Mattaj IW, Görlich D. Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex. The Embo Journal. 16: 1153-63. PMID 9135132 DOI: 10.1093/emboj/16.6.1153  0.56
1997 Gamberi C, Izaurralde E, Beisel C, Mattaj IW. Interaction between the human nuclear cap-binding protein complex and hnRNP F. Molecular and Cellular Biology. 17: 2587-97. PMID 9111328  0.56
1997 Izaurralde E, Jarmolowski A, Beisel C, Mattaj IW, Dreyfuss G, Fischer U. A role for the M9 transport signal of hnRNP A1 in mRNA nuclear export. The Journal of Cell Biology. 137: 27-35. PMID 9105034 DOI: 10.1083/jcb.137.1.27  0.56
1997 Palacios I, Izaurralde E. An immersion in nucleocytoplasmic transport at the Garda lake Trends in Cell Biology. 7: 81-83. DOI: 10.1016/S0962-8924(96)30079-2  0.56
1996 Stutz F, Izaurralde E, Mattaj IW, Rosbash M. A role for nucleoporin FG repeat domains in export of human immunodeficiency virus type 1 Rev protein and RNA from the nucleus. Molecular and Cellular Biology. 16: 7144-50. PMID 8943370  0.52
1996 Görlich D, Kraft R, Kostka S, Vogel F, Hartmann E, Laskey RA, Mattaj IW, Izaurralde E. Importin provides a link between nuclear protein import and U snRNA export. Cell. 87: 21-32. PMID 8858145 DOI: 10.1016/S0092-8674(00)81319-7  0.56
1996 Lewis JD, Izaurralde E, Jarmolowski A, McGuigan C, Mattaj LW. A nuclear cap-binding complex facilitates association of U1 snRNP with the cap-proximal 5' splice site Genes and Development. 10: 1683-1698. PMID 8682298  0.56
1996 Visa N, Izaurralde E, Ferreira J, Daneholt B, Mattaj IW. A nuclear cap-binding complex binds Balbiani ring pre-mRNA cotranscriptionally and accompanies the ribonucleoprotein particle during nuclear export Journal of Cell Biology. 133: 5-14. PMID 8601613 DOI: 10.1083/jcb.133.1.5  0.56
1996 Cörlich D, Izaurralde E, Mattai LW. Roles of importin in nucleocytoplasmic transport Biochemical Society Transactions. 24.  0.56
1995 Izaurralde E, McGuigan C, Mattaj IW. Nuclear localization of a Cap-binding protein complex Cold Spring Harbor Symposia On Quantitative Biology. 60: 669-675. PMID 8824441  0.52
1995 Izaurralde E, Lewis J, Gamberi C, Jarmolowski A, McGuigan C, Mattaj IW. A cap-binding protein complex mediating U snRNA export Nature. 376: 709-712. PMID 7651522  0.56
1995 Izaurralde E, Mattal IW. RNA Export Cell. 81: 153-159. PMID 7537634 DOI: 10.1016/0092-8674(95)90323-2  0.56
1995 Izaurralde E, Mattaj IW, Goldfarb DS. Nuclear transport of uracil-rich small nuclear ribonucleoprotein particles Membrane Protein Transport. 2: 123-159. DOI: 10.1016/S1874-592X(06)80007-7  0.56
1994 Izaurralde E, Lewis J, McGuigan C, Jankowska M, Darzynkiewicz E, Mattaj LW. A nuclear cap binding protein complex involved in pre-mRNA splicing Cell. 78: 657-668. PMID 8069914 DOI: 10.1016/0092-8674(94)90530-4  0.56
1994 Jarmolowski A, Boelens WC, Izaurralde E, Mattaj IW. Nuclear export of different classes of RNA is mediated by specific factors Journal of Cell Biology. 124: 627-635. PMID 7509815  0.56
1993 Mattaj IW, Boelens W, Izaurralde E, Jarmolowski A, Kambach C. Nucleocytoplasmic transport and snRNP assembly Molecular Biology Reports. 18: 79-83. PMID 8232299 DOI: 10.1007/BF00986760  0.52
1992 Izaurralde E, Stepinski J, Darzynkiewicz E, Mattaj IW. A cap binding protein that may mediate nuclear export of RNA polymerase II-transcribed RNAs Journal of Cell Biology. 118: 1287-1295. PMID 1522107  0.56
1992 Izaurralde E, Mattaj IW. Transport of RNA between nucleus and cytoplasm Seminars in Cell Biology. 3: 279-288. PMID 1384772 DOI: 10.1016/1043-4682(92)90029-U  0.56
1991 Fankhauser C, Izaurralde E, Adachi Y, Wingfield P, Laemmli UK. Specific Complex of Human Immunodeficiency Virus Type 1 Rev and Nucleolar B23 Proteins: Dissociation by the Rev Response Element Molecular and Cellular Biology. 11: 2567-2575. PMID 2017166  0.56
1991 Raska I, Michel LS, Jarnik M, Dundr M, Fakan S, Gasser S, Gassmann M, Hubscher U, Izaurralde E, Martinez E, Richter A, Dubochet J. Ultrastructural cryoimmunocytochemistry is a convenient tool for the study of DNA replication in cultured cells Journal of Electron Microscopy Technique. 18: 91-105. PMID 1886006  0.56
1989 Käs E, Izaurralde E, Laemmli UK. Specific inhibition of DNA Binding to nuclear scaffolds and histone H1 by distamycin. The role of oligo(dA) · oligo(dT) tracts Journal of Molecular Biology. 210: 587-599. PMID 2614835 DOI: 10.1016/0022-2836(89)90134-4  0.56
1989 Izaurralde E, Käs E, Laemmli UK. Highly preferential nucleation of histone H1 assembly on scaffold-associated regions Journal of Molecular Biology. 210: 573-585. PMID 2614834 DOI: 10.1016/0022-2836(89)90133-2  0.56
1989 Manen D, Izaurralde E, Churchward G, Caro L. Transcription events in the origin of replication of plasmid pSC101 Journal of Bacteriology. 171: 6482-6492. PMID 2556365  0.52
1988 Izaurralde E, Mirkovitcht J, Laemmli UK. Interaction of DNA with nuclear scaffolds in vitro Journal of Molecular Biology. 200: 111-125. PMID 3132558 DOI: 10.1016/0022-2836(88)90337-3  0.52
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