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Meredith L. Leong, Ph.D. - Publications

Affiliations: 
2002 University of California, Berkeley, Berkeley, CA, United States 
Area:
Cell Biology, Molecular Biology
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31 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Deng W, Desbien AL, Gauthier KS, Reiner G, Corrales L, Schroeder T, Glickman LH, Surh NH, Francica B, Leong JJ, Metchette K, Zheng L, Cho C, Feng Y, McKenna JM, ... ... Leong ML, et al. Abstract PR09: ADU-S100 (MIW815) synergizes with checkpoint blockade to elicit an antitumor CD8+ T-cell response to control distal tumors Cancer Immunology Research. 8. DOI: 10.1158/2326-6074.Tumimm18-Pr09  0.387
2019 Hanson WG, Benanti EL, Lemmens EE, Liu W, Skoble J, Leong ML, Rae CS, Fassò M, Brockstedt DG, Chen C, Portnoy DA, Dubensky TW, Lauer P. A potent and effective suicidal vaccine platform. Infection and Immunity. PMID 31235641 DOI: 10.1128/Iai.00144-19  0.351
2019 Voets E, Kreijtz J, Vink P, Hulsik DL, Parade M, Spijkers S, Reinieren-Beeren I, Rens J, Janssen W, Zandvoort Pv, Francica B, Leong M, Elsas Av, Eenennaam Hv. Abstract 1203: Preclinical development of ADU-1805, a highly selective pan-allele anti-SIRPα antibody that blocks the SIRPα-CD47 innate immune checkpoint Cancer Research. 79: 1203-1203. DOI: 10.1158/1538-7445.Am2019-1203  0.357
2019 Corrales L, Desbien AL, Gauthier KES, Deng W, Schroeder T, Reiner GL, Surh N, Francica B, Metchette K, Ndubaku CO, McKenna JM, Feng Y, Zheng L, Bender SL, Cho CY, ... ... Leong ML, et al. Abstract 1202: Tumor cell intrinsic STING signaling demonstrates minimal contribution to the anti-tumor response elicited by the STING agonist ADU-S100 (MIW815) Cancer Research. 79: 1202-1202. DOI: 10.1158/1538-7445.Am2019-1202  0.431
2018 Sivick KE, Desbien AL, Glickman LH, Reiner GL, Corrales L, Surh NH, Hudson TE, Vu UT, Francica BJ, Banda T, Katibah GE, Kanne DB, Leong JJ, Metchette K, Bruml JR, ... ... Leong ML, et al. Magnitude of Therapeutic STING Activation Determines CD8 T Cell-Mediated Anti-tumor Immunity. Cell Reports. 25: 3074-3085.e5. PMID 30540940 DOI: 10.1016/J.Celrep.2018.11.047  0.426
2018 Johnson LE, Brockstedt D, Leong M, Lauer P, Theisen E, Sauer JD, McNeel DG. Heterologous vaccination targeting prostatic acid phosphatase (PAP) using DNA and vaccines elicits superior anti-tumor immunity dependent on CD4+ T cells elicited by DNA priming. Oncoimmunology. 7: e1456603. PMID 30221049 DOI: 10.1080/2162402X.2018.1456603  0.343
2018 Deng W, Lira V, Hudson TE, Lemmens EE, Hanson WG, Flores R, Barajas G, Katibah GE, Desbien AL, Lauer P, Leong ML, Portnoy DA, Dubensky TW. Recombinant promotes tumor rejection by CD8 T cell-dependent remodeling of the tumor microenvironment. Proceedings of the National Academy of Sciences of the United States of America. PMID 30038013 DOI: 10.1073/Pnas.1801910115  0.403
2018 Van Dis E, Sogi KM, Rae CS, Sivick KE, Surh NH, Leong ML, Kanne DB, Metchette K, Leong JJ, Bruml JR, Chen V, Heydari K, Cadieux N, Evans T, McWhirter SM, et al. STING-Activating Adjuvants Elicit a Th17 Immune Response and Protect against Mycobacterium tuberculosis Infection. Cell Reports. 23: 1435-1447. PMID 29719256 DOI: 10.1016/J.Celrep.2018.04.003  0.32
2018 Francica BJ, Ghasemzadeh A, Desbien AL, Theodros D, Sivick KE, Reiner GL, Hix Glickman L, Marciscano AE, Sharabi AB, Leong ML, McWhirter SM, Dubensky TW, Pardoll DM, Drake CG. TNFalpha and radio-resistant stromal cells are essential for therapeutic efficacy of cyclic dinucleotide STING agonists in non-immunogenic tumors. Cancer Immunology Research. PMID 29472271 DOI: 10.1158/2326-6066.Cir-17-0263  0.407
2018 Desbien AL, Gauthier KS, Corrales L, Reiner G, Glickman LH, Katibah G, Hudson TE, Vu U, Surh NH, Francica B, Deng W, Kanne DB, Leong JJ, Ndubaku C, Metchette K, ... ... Leong ML, et al. Abstract 631: Intratumoral activation of STING with a synthetic cyclic dinucleotide elicits antitumor CD8 T-cell immunity that effectively combines with checkpoint inhibitors Cancer Research. 78: 631-631. DOI: 10.1158/1538-7445.Am2018-631  0.406
2018 Hendriks M, Kreijtz J, Vink P, Hulsik DL, Lodewijks I, Bertens A, Crommert Jvd, Habraken M, Janssen W, Stammen-Vogelzang J, Gardner O, Deng W, Leong M, McWhirter S, Eenennaam Hv, et al. Abstract 1702: Assessment of pharmacology and toxicology of anti-CTLA-4 antibody (ADU-1604) in non-human primates and evaluation of local anti-CTLA-4 application Cancer Research. 78: 1702-1702. DOI: 10.1158/1538-7445.Am2018-1702  0.335
2017 Deng W, Liu W, Hudson T, Rae CS, Lemmens E, Desbien A, Hanson B, Lauer P, Dubensky TW, Leong M. Abstract B50: Synergistic antitumor efficacy in mice with immunotherapy regimens combining recombinant live-attenuated Listeria with immune checkpoint inhibitors Cancer Immunology Research. 5. DOI: 10.1158/2326-6074.Tumimm16-B50  0.416
2017 Lee J, Leong M, Huang Y, Thompson BJ, Rosengren S, Blouw B, Brockstedt DG, Thompson CB. Abstract LB-198: Combination of PEGylated recombinant hyaluronidase PH20 (PEGPH20) with live-attenuated, double-deleted (LADD) Listeria enhances tumor infiltrating CD8+ T cell response and antitumor efficacy in mice Cancer Research. 77. DOI: 10.1158/1538-7445.Am2017-Lb-198  0.399
2016 McWhirter SM, Glickman LH, Desbien T, Gauthier KS, Kanne D, Kasibhatla S, Li J, Pferdekamper AC, Katibah G, Lemmens E, Corrales L, Leong M, Ndubaku C, Leong J, Sung L, et al. Abstract B020: STING activation in the tumor microenvironment using a synthetic human STING-activating cyclic dinucleotide induces potent antitumor immunity Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-B020  0.421
2016 Deng W, Tsujikawa T, Nair N, Hudson T, Liu W, Rae CS, Lemmens EE, Desbien AW, Hanson W, Lauer P, Coussens LM, Brockstedt DG, Dubensky TW, Leong ML. Abstract A013: Favorable changes in tumor microenvironment following intravenous dosing with live attenuatedListeria monocytogenes-based immunotherapy Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-A013  0.406
2015 Fu J, Kanne DB, Leong M, Glickman LH, McWhirter SM, Lemmens E, Mechette K, Leong JJ, Lauer P, Liu W, Sivick KE, Zeng Q, Soares KC, Zheng L, Portnoy DA, et al. STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade. Science Translational Medicine. 7: 283ra52. PMID 25877890 DOI: 10.1126/Scitranslmed.Aaa4306  0.423
2015 Fu J, Kim Y, Kanne D, Leong M, Zeng Q, Sen R, Amstrong TD, Drake CG, Dubensky T, Pardoll D, Gadkare S. Cyclic dinucleotides (CDNs) reversed T cells tolerance in anti-tumor immunotherapy Journal For Immunotherapy of Cancer. 3: P268. DOI: 10.1186/2051-1426-3-S2-P268  0.344
2014 Glickman LH, Kanne DB, McWhirter SM, Leong ML, Lemmens EE, Metchette K, Vance RE, Pardoll DM, Dubensky TW. Abstract 2566: Activation of tumor-initiated T cell priming and tumor destruction with potent STING-activating cyclic dinucleotide derivatives Cancer Research. 74: 2566-2566. DOI: 10.1158/1538-7445.Am2014-2566  0.424
2013 Leong M, Kanne D, Glickman L, Lemmens E, Lauer P, Metchette K, Burdette D, Diner E, Fu J, Soares K, Brockstedt D, Portnoy D, Vance R, Kim Y, Jaffee E, et al. Modified STING-activating cyclic dinucleotide derivatives significantly enhance the anti-tumor activity of therapeutic vaccines Journal For Immunotherapy of Cancer. 1: O20. DOI: 10.1186/2051-1426-1-S1-O20  0.447
2013 Dubensky TW, Leong ML, Kanne DB, Lemmens EE, Metchette K, Liu W, Fasso M, Fu J, Woodward JJ, Pardoll D, Portnoy DA, Kim YJ. Abstract 4573: STINGVAX - A novel tumor vaccine with cyclic dinucleotides - can induce potent anti-tumor responsesin vivo. Cancer Research. 73: 4573-4573. DOI: 10.1158/1538-7445.Am2013-4573  0.442
2008 Skoberne M, Yewdall A, Bahjat KS, Godefroy E, Lauer P, Lemmens E, Liu W, Luckett W, Leong M, Dubensky TW, Brockstedt DG, Bhardwaj N. KBMA Listeria monocytogenes is an effective vector for DC-mediated induction of antitumor immunity. The Journal of Clinical Investigation. 118: 3990-4001. PMID 19033668 DOI: 10.1172/Jci31350  0.321
2007 Bahjat KS, Prell RA, Allen HE, Liu W, Lemmens EE, Leong ML, Portnoy DA, Dubensky TW, Brockstedt DG, Giedlin MA. Activation of immature hepatic NK cells as immunotherapy for liver metastatic disease. Journal of Immunology (Baltimore, Md. : 1950). 179: 7376-84. PMID 18025181 DOI: 10.4049/Jimmunol.179.11.7376  0.408
2007 Buse P, Maiyar AC, Failor KL, Tran S, Leong ML, Firestone GL. The stimulus-dependent co-localization of serum- and glucocorticoid-regulated protein kinase (Sgk) and Erk/MAPK in mammary tumor cells involves the mutual interaction with the importin-alpha nuclear import protein. Experimental Cell Research. 313: 3261-75. PMID 17692313 DOI: 10.1016/J.Yexcr.2007.07.009  0.592
2006 Yoshimura K, Jain A, Allen HE, Laird LS, Chia CY, Ravi S, Brockstedt DG, Giedlin MA, Bahjat KS, Leong ML, Slansky JE, Cook DN, Dubensky TW, Pardoll DM, Schulick RD. Selective targeting of antitumor immune responses with engineered live-attenuated Listeria monocytogenes. Cancer Research. 66: 1096-104. PMID 16424046 DOI: 10.1158/0008-5472.Can-05-2307  0.392
2005 Brockstedt DG, Hampl J, Bahjat K, Lutz E, Leong M, Liu W, Pardoll D, Giedlin M, Jaffee E, Dubensky T. Characterization of Mesothelin-Specific T Cell Responses in Healthy Individuals Journal of Immunotherapy. 28: 631. DOI: 10.1097/01.Cji.0000191007.62728.66  0.301
2004 Brockstedt DG, Giedlin MA, Leong ML, Bahjat KS, Gao Y, Luckett W, Liu W, Cook DN, Portnoy DA, Dubensky TW. Listeria-based cancer vaccines that segregate immunogenicity from toxicity. Proceedings of the National Academy of Sciences of the United States of America. 101: 13832-7. PMID 15365184 DOI: 10.1073/Pnas.0406035101  0.384
2003 Maiyar AC, Leong ML, Firestone GL. Importin-alpha mediates the regulated nuclear targeting of serum- and glucocorticoid-inducible protein kinase (Sgk) by recognition of a nuclear localization signal in the kinase central domain. Molecular Biology of the Cell. 14: 1221-39. PMID 12631736 DOI: 10.1091/Mbc.E02-03-0170  0.643
2003 Leong ML, Maiyar AC, Kim B, O'Keeffe BA, Firestone GL. Expression of the serum- and glucocorticoid-inducible protein kinase, Sgk, is a cell survival response to multiple types of environmental stress stimuli in mammary epithelial cells. The Journal of Biological Chemistry. 278: 5871-82. PMID 12488318 DOI: 10.1074/Jbc.M211649200  0.655
2001 Wang J, Barbry P, Maiyar AC, Rozansky DJ, Bhargava A, Leong M, Firestone GL, Pearce D. SGK integrates insulin and mineralocorticoid regulation of epithelial sodium transport. American Journal of Physiology. Renal Physiology. 280: F303-13. PMID 11208606 DOI: 10.1152/Ajprenal.2001.280.2.F303  0.632
2000 Bell LM, Leong ML, Kim B, Wang E, Park J, Hemmings BA, Firestone GL. Hyperosmotic stress stimulates promoter activity and regulates cellular utilization of the serum- and glucocorticoid-inducible protein kinase (Sgk) by a p38 MAPK-dependent pathway. The Journal of Biological Chemistry. 275: 25262-72. PMID 10842172 DOI: 10.1074/Jbc.M002076200  0.723
1999 Park J, Leong ML, Buse P, Maiyar AC, Firestone GL, Hemmings BA. Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway. The Embo Journal. 18: 3024-33. PMID 10357815 DOI: 10.1093/Emboj/18.11.3024  0.679
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