Jeffrey D. Rudolf, Ph.D. - Publications

2007-2013 Chemistry University of Utah, Salt Lake City, UT 
 2013-2018 Chemistry The Scripps Research Institute, Scripps Florida 
 2018- Chemistry University of Florida, Gainesville, Gainesville, FL, United States 
Natural Products, Biosynthesis, Enzymology, Genome Mining, Bioengineering

37 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Dong LB, Liu YC, Cepeda AJ, Kalkreuter E, Deng MR, Rudolf JD, Chang C, Joachimiak A, Phillips GN, Shen B. Characterization and Crystal Structure of a Nonheme Diiron Monooxygenase Involved in Platensimycin and Platencin Biosynthesis. Journal of the American Chemical Society. PMID 31291107 DOI: 10.1021/jacs.9b06183  1
2019 Su M, Qiu L, Deng Y, Ruiz CH, Rudolf JD, Dong LB, Feng X, Cameron MD, Shen B, Duan Y, Huang Y. Evaluation of Platensimycin and Platensimycin-Inspired Thioether Analogues against Methicillin-Resistant Staphylococcus aureus in Topical and Systemic Infection Mouse Models. Molecular Pharmaceutics. PMID 31244223 DOI: 10.1021/acs.molpharmaceut.9b00293  1
2019 Dong LB, Zhang X, Shen B, Rudolf JD, Deng MR, Kalkreuter E, Cepeda AJ, Renata H. Cryptic and Stereospecific Hydroxylation, Oxidation, and Reduction in Platensimycin and Platencin Biosynthesis. Journal of the American Chemical Society. PMID 30735041 DOI: 10.1021/jacs.8b13452  1
2018 Rudolf JD, Dong LB, Zhang X, Renata H, Shen B. Cytochrome P450-Catalyzed Hydroxylation Initiating Ether Formation in Platensimycin Biosynthesis. Journal of the American Chemical Society. PMID 30216060 DOI: 10.1021/jacs.8b08012  1
2018 Annaval T, Han L, Rudolf JD, Xie G, Yang D, Chang CY, Ma M, Crnovcic I, Miller MD, Soman J, Xu W, Phillips GN, Shen B. Biochemical and structural characterization of TtnD, a prenylated FMN-dependent decarboxylase from the tautomycetin biosynthetic pathway. Acs Chemical Biology. PMID 30152678 DOI: 10.1021/acschembio.8b00673  1
2018 Kwong T, Ma M, Pan G, Hindra, Yang D, Yang C, Lohman JR, Rudolf JD, Cleveland JL, Shen B. P450-Catalyzed Tailoring Steps in Leinamycin Biosynthesis Featuring Regio- and Stereoselective Hydroxylations and Substrate Promiscuities. Biochemistry. PMID 30070831 DOI: 10.1021/acs.biochem.8b00623  1
2018 Chang CY, Yan X, Crnovcic I, Annaval T, Chang C, Nocek B, Rudolf JD, Yang D, Hindra, Babnigg G, Joachimiak A, Phillips GN, Shen B. Resistance to Enediyne Antitumor Antibiotics by Sequestration. Cell Chemical Biology. PMID 29937405 DOI: 10.1016/j.chembiol.2018.05.012  1
2018 Dong LB, Rudolf JD, Kang D, Wang N, He CQ, Deng Y, Huang Y, Houk KN, Duan Y, Shen B. Biosynthesis of thiocarboxylic acid-containing natural products. Nature Communications. 9: 2362. PMID 29915173 DOI: 10.1038/s41467-018-04747-y  1
2018 Wang N, Rudolf JD, Dong LB, Osipiuk J, Hatzos-Skintges C, Endres M, Chang CY, Babnigg G, Joachimiak A, Phillips GN, Shen B. Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme. Nature Chemical Biology. PMID 29867143 DOI: 10.1038/s41589-018-0061-0  1
2018 Shen B, Dong LB, Rudolf JD, Deng MR, Yan X. Discovery of the Tiancilactone Antibiotics by Genome Mining of Atypical Bacterial Type II Diterpene Synthases. Chembiochem : a European Journal of Chemical Biology. PMID 29806086 DOI: 10.1002/cbic.201800285  1
2018 Chang CY, Lohman JR, Huang T, Michalska K, Bigelow L, Rudolf JD, Jedrzejczak R, Yan X, Ma M, Babnigg G, Joachimiak A, Phillips GN, Shen B. Structural Insights into the Free-standing Condensation Enzyme SgcC5 Catalyzing Ester Bond Formation in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027. Biochemistry. PMID 29533601 DOI: 10.1021/acs.biochem.8b00174  1
2017 Annaval T, Rudolf JD, Chang CY, Lohman JR, Kim Y, Bigelow L, Jedrzejczak R, Babnigg G, Joachimiak A, Phillips GN, Shen B. Crystal Structure of Thioesterase SgcE10 Supporting Common Polyene Intermediates in 9- and 10-Membered Enediyne Core Biosynthesis. Acs Omega. 2: 5159-5169. PMID 28884166 DOI: 10.1021/acsomega.7b00933  1
2017 Rudolf JD, Chang CY, Ma M, Shen B. Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function. Natural Product Reports. PMID 28758170 DOI: 10.1039/c7np00034k  1
2017 Falzone M, Crespo E, Jones K, Khan G, Korn VL, Patel A, Patel M, Patel K, Perkins C, Siddiqui S, Stenger D, Yu E, Gelber M, Scheffler R, Nayda V, ... ... Rudolf JD, et al. Nutritional control of antibiotic production by Streptomyces platensis MA7327: importance of l-aspartic acid. The Journal of Antibiotics. PMID 28465627 DOI: 10.1038/ja.2017.49  1
2017 Dong LB, Rudolf JD, Lin L, Ruiz C, Cameron MD, Shen B. In vivo instability of platensimycin and platencin: Synthesis and biological evaluation of urea- and carbamate-platensimycin. Bioorganic & Medicinal Chemistry. PMID 28237556 DOI: 10.1016/j.bmc.2017.02.028  1
2016 Yan X, Ge H, Huang T, Hindra, Yang D, Teng Q, Crnovčić I, Li X, Rudolf JD, Lohman JR, Gansemans Y, Zhu X, Huang Y, Zhao LX, Jiang Y, et al. Strain Prioritization and Genome Mining for Enediyne Natural Products. Mbio. 7. PMID 27999165 DOI: 10.1128/mBio.02104-16  1
2016 Rudolf JD, Dong LB, Manoogian K, Shen B. Biosynthetic Origin of the Ether Ring in Platensimycin. Journal of the American Chemical Society. PMID 27966343 DOI: 10.1021/jacs.6b09818  1
2016 Rudolf JD, Dong LB, Shen B. Platensimycin and Platencin: Inspirations for Chemistry, Biology, Enzymology, and Medicine. Biochemical Pharmacology. PMID 27865713 DOI: 10.1016/j.bcp.2016.11.013  1
2016 Dong LB, Rudolf JD, Shen B. A Mutasynthetic Library of Platensimycin and Platencin Analogues. Organic Letters. PMID 27599271 DOI: 10.1021/acs.orglett.6b02248  1
2016 Chang CY, Lohman JR, Cao H, Tan K, Rudolf JD, Ma M, Xu W, Bingman CA, Yennamalli RM, Bigelow L, Babnigg G, Yan X, Joachimiak A, Phillips GN, Shen B. Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase that Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate in Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus. Biochemistry. PMID 27560143 DOI: 10.1021/acs.biochem.6b00713  1
2016 Ma M, Rateb ME, Yang D, Rudolf JD, Zhu X, Huang Y, Zhao LX, Jiang Y, Duan Y, Shen B. Germicidins H-J from Streptomyces sp. CB00361. The Journal of Antibiotics. PMID 27507632 DOI: 10.1038/ja.2016.100  1
2016 Rudolf JD, Dong LB, Cao H, Hatzos-Skintges C, Osipiuk J, Endres M, Chang CY, Ma M, Babnigg G, Joachimiak A, Phillips GN, Shen B. Structure of the ent-Copalyl Diphosphate Synthase PtmT2 from Streptomyces platensis CB00739, a Bacterial Type II Diterpene Synthase. Journal of the American Chemical Society. PMID 27490479 DOI: 10.1021/jacs.6b04317  1
2016 Huang T, Chang CY, Lohman JR, Rudolf JD, Kim Y, Chang C, Yang D, Ma M, Yan X, Crnovcic I, Bigelow L, Clancy S, Bingman CA, Yennamalli RM, Babnigg G, et al. Crystal structure of SgcJ, an NTF2-like superfamily protein involved in biosynthesis of the nine-membered enediyne antitumor antibiotic C-1027. The Journal of Antibiotics. PMID 27406907 DOI: 10.1038/ja.2016.88  1
2016 Dong LB, Rudolf JD, Shen B. Antibacterial sulfur-containing platensimycin and platencin congeners from Streptomyces platensis SB12029. Bioorganic & Medicinal Chemistry. PMID 27134119 DOI: 10.1016/j.bmc.2016.04.026  1
2015 Rudolf JD, Bigelow L, Chang C, Cuff ME, Lohman JR, Chang CY, Ma M, Yang D, Clancy S, Babnigg G, Joachimiak A, Phillips GN, Shen B. Crystal Structure of the Zorbamycin-Binding Protein ZbmA, the Primary Self-Resistance Element in Streptomyces flavoviridis ATCC21892. Biochemistry. PMID 26512730 DOI: 10.1021/acs.biochem.5b01008  1
2015 Ma M, Rateb ME, Teng Q, Yang D, Rudolf JD, Zhu X, Huang Y, Zhao LX, Jiang Y, Li X, Rader C, Duan Y, Shen B. Angucyclines and Angucyclinones from Streptomyces sp. CB01913 Featuring C-Ring Cleavage and Expansion. Journal of Natural Products. PMID 26335269 DOI: 10.1021/acs.jnatprod.5b00601  1
2015 Rudolf JD, Yan X, Shen B. Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery. Journal of Industrial Microbiology & Biotechnology. PMID 26318027 DOI: 10.1007/s10295-015-1671-0  1
2015 Rudolf JD, Dong LB, Huang T, Shen B. A genetically amenable platensimycin- and platencin-overproducer as a platform for biosynthetic explorations: a showcase of PtmO4, a long-chain acyl-CoA dehydrogenase. Molecular Biosystems. PMID 26055255 DOI: 10.1039/c5mb00303b  1
2015 Shen B, Hindra, Yan X, Huang T, Ge H, Yang D, Teng Q, Rudolf JD, Lohman JR. Enediynes: Exploration of microbial genomics to discover new anticancer drug leads. Bioorganic & Medicinal Chemistry Letters. 25: 9-15. PMID 25434000 DOI: 10.1016/j.bmcl.2014.11.019  1
2014 Coughlin JM, Rudolf JD, Wendt-Pienkowski E, Wang L, Unsin C, Galm U, Yang D, Tao M, Shen B. BlmB and TlmB provide resistance to the bleomycin family of antitumor antibiotics by N-acetylating metal-free bleomycin, tallysomycin, phleomycin, and zorbamycin. Biochemistry. 53: 6901-9. PMID 25299801 DOI: 10.1021/bi501121e  1
2014 Hindra, Huang T, Yang D, Rudolf JD, Xie P, Xie G, Teng Q, Lohman JR, Zhu X, Huang Y, Zhao LX, Jiang Y, Duan Y, Shen B. Strain prioritization for natural product discovery by a high-throughput real-time PCR method. Journal of Natural Products. 77: 2296-303. PMID 25238028 DOI: 10.1021/np5006168  1
2014 Ge HM, Huang T, Rudolf JD, Lohman JR, Huang SX, Guo X, Shen B. Enediyne polyketide synthases stereoselectively reduce the β-ketoacyl intermediates to β-D-hydroxyacyl intermediates in enediyne core biosynthesis. Organic Letters. 16: 3958-61. PMID 25019332 DOI: 10.1021/ol501767v  1
2014 Peterson RM, Huang T, Rudolf JD, Smanski MJ, Shen B. Mechanisms of self-resistance in the platensimycin- and platencin-producing Streptomyces platensis MA7327 and MA7339 strains. Chemistry & Biology. 21: 389-97. PMID 24560608 DOI: 10.1016/j.chembiol.2014.01.005  1
2014 Xie P, Ma M, Rateb ME, Shaaban KA, Yu Z, Huang SX, Zhao LX, Zhu X, Yan Y, Peterson RM, Lohman JR, Yang D, Yin M, Rudolf JD, Jiang Y, et al. Biosynthetic potential-based strain prioritization for natural product discovery: a showcase for diterpenoid-producing actinomycetes. Journal of Natural Products. 77: 377-87. PMID 24484381 DOI: 10.1021/np401063s  1
2013 Rudolf JD, Poulter CD. Tyrosine O-prenyltransferase SirD catalyzes S-, C-, and N-prenylations on tyrosine and tryptophan derivatives. Acs Chemical Biology. 8: 2707-14. PMID 24083562 DOI: 10.1021/cb400691z  1
2013 Rudolf JD, Wang H, Poulter CD. Correction to multisite prenylation of 4-substituted tryptophans by dimethylallyltryptophan synthase. Journal of the American Chemical Society. 135: 10879. PMID 23848360 DOI: 10.1021/ja405989j  1
2013 Rudolf JD, Wang H, Poulter CD. Multisite prenylation of 4-substituted tryptophans by dimethylallyltryptophan synthase. Journal of the American Chemical Society. 135: 1895-902. PMID 23301871 DOI: 10.1021/ja310734n  1
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