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Jeffrey D. Rudolf, Ph.D. - Publications

Affiliations: 
2007-2013 Chemistry University of Utah, Salt Lake City, UT 
 2013-2018 Chemistry The Scripps Research Institute, Scripps Florida 
 2018- Chemistry University of Florida, Gainesville, Gainesville, FL, United States 
Area:
Natural Products, Biosynthesis, Enzymology, Genome Mining, Bioengineering
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44/56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Fluegel LL, Deng MR, Su P, Kalkreuter E, Yang D, Rudolf JD, Dong LB, Shen B. Development of platensimycin, platencin, and platensilin overproducers by biosynthetic pathway engineering and fermentation medium optimization. Journal of Industrial Microbiology & Biotechnology. PMID 38262768 DOI: 10.1093/jimb/kuae003  0.486
2023 Wang Z, Yang Q, He J, Li H, Pan X, Li Z, Xu HM, Rudolf J, Tantillo D, Dong LB. Cytochrome P450 Mediated Cyclization in Eunicellane Derived Diterpenoid Biosynthesis. Angewandte Chemie (International Ed. in English). e202312490. PMID 37735947 DOI: 10.1002/anie.202312490  0.305
2022 Zheng YZ, Cui J, Wang YL, Huang SJ, Lin EC, Huang SC, Rudolf JD, Yan X, Chang CY. The Structure-Function Relationship of Human Bleomycin Hydrolase: Mutation of a Cysteine Protease into a Serine Protease. Chembiochem : a European Journal of Chemical Biology. e202200186. PMID 35467071 DOI: 10.1002/cbic.202200186  0.325
2021 Zhu C, Xu B, Adpressa DA, Rudolf JD, Loesgen S. Discovery and biosynthesis of a structurally dynamic antibacterial diterpenoid. Angewandte Chemie (International Ed. in English). PMID 33780586 DOI: 10.1002/anie.202102453  0.304
2020 Rudolf JD, Alsup TA, Xu B, Li Z. Bacterial terpenome. Natural Product Reports. PMID 33169126 DOI: 10.1039/d0np00066c  0.334
2020 Zhang X, King-Smith E, Dong LB, Yang LC, Rudolf JD, Shen B, Renata H. Divergent synthesis of complex diterpenes through a hybrid oxidative approach. Science (New York, N.Y.). 369: 799-806. PMID 32792393 DOI: 10.1126/Science.Abb8271  0.496
2019 Rudolf JD, Chang CY. Terpene synthases in disguise: enzymology, structure, and opportunities of non-canonical terpene synthases. Natural Product Reports. PMID 31650156 DOI: 10.1039/c9np00051h  0.317
2019 Dong LB, Liu YC, Cepeda AJ, Kalkreuter E, Deng MR, Rudolf JD, Chang C, Joachimiak A, Phillips GN, Shen B. Characterization and Crystal Structure of a Nonheme Diiron Monooxygenase Involved in Platensimycin and Platencin Biosynthesis. Journal of the American Chemical Society. PMID 31291107 DOI: 10.1021/jacs.9b06183  0.603
2019 Su M, Qiu L, Deng Y, Ruiz CH, Rudolf JD, Dong LB, Feng X, Cameron MD, Shen B, Duan Y, Huang Y. Evaluation of Platensimycin and Platensimycin-Inspired Thioether Analogues against Methicillin-Resistant Staphylococcus aureus in Topical and Systemic Infection Mouse Models. Molecular Pharmaceutics. PMID 31244223 DOI: 10.1021/Acs.Molpharmaceut.9B00293  0.491
2019 Dong LB, Zhang X, Shen B, Rudolf JD, Deng MR, Kalkreuter E, Cepeda AJ, Renata H. Cryptic and Stereospecific Hydroxylation, Oxidation, and Reduction in Platensimycin and Platencin Biosynthesis. Journal of the American Chemical Society. PMID 30735041 DOI: 10.1021/Jacs.8B13452  0.559
2018 Rudolf JD, Dong LB, Zhang X, Renata H, Shen B. Cytochrome P450-Catalyzed Hydroxylation Initiating Ether Formation in Platensimycin Biosynthesis. Journal of the American Chemical Society. PMID 30216060 DOI: 10.1021/Jacs.8B08012  0.558
2018 Annaval T, Han L, Rudolf JD, Xie G, Yang D, Chang CY, Ma M, Crnovcic I, Miller MD, Soman J, Xu W, Phillips GN, Shen B. Biochemical and structural characterization of TtnD, a prenylated FMN-dependent decarboxylase from the tautomycetin biosynthetic pathway. Acs Chemical Biology. PMID 30152678 DOI: 10.1021/Acschembio.8B00673  0.604
2018 Kwong T, Ma M, Pan G, Hindra, Yang D, Yang C, Lohman JR, Rudolf JD, Cleveland JL, Shen B. P450-Catalyzed Tailoring Steps in Leinamycin Biosynthesis Featuring Regio- and Stereoselective Hydroxylations and Substrate Promiscuities. Biochemistry. PMID 30070831 DOI: 10.1021/Acs.Biochem.8B00623  0.777
2018 Chang CY, Yan X, Crnovcic I, Annaval T, Chang C, Nocek B, Rudolf JD, Yang D, Hindra, Babnigg G, Joachimiak A, Phillips GN, Shen B. Resistance to Enediyne Antitumor Antibiotics by Sequestration. Cell Chemical Biology. PMID 29937405 DOI: 10.1016/J.Chembiol.2018.05.012  0.53
2018 Dong LB, Rudolf JD, Kang D, Wang N, He CQ, Deng Y, Huang Y, Houk KN, Duan Y, Shen B. Biosynthesis of thiocarboxylic acid-containing natural products. Nature Communications. 9: 2362. PMID 29915173 DOI: 10.1038/S41467-018-04747-Y  0.573
2018 Wang N, Rudolf JD, Dong LB, Osipiuk J, Hatzos-Skintges C, Endres M, Chang CY, Babnigg G, Joachimiak A, Phillips GN, Shen B. Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme. Nature Chemical Biology. PMID 29867143 DOI: 10.1038/S41589-018-0061-0  0.563
2018 Shen B, Dong LB, Rudolf JD, Deng MR, Yan X. Discovery of the Tiancilactone Antibiotics by Genome Mining of Atypical Bacterial Type II Diterpene Synthases. Chembiochem : a European Journal of Chemical Biology. PMID 29806086 DOI: 10.1002/Cbic.201800285  0.581
2018 Chang CY, Lohman JR, Huang T, Michalska K, Bigelow L, Rudolf JD, Jedrzejczak R, Yan X, Ma M, Babnigg G, Joachimiak A, Phillips GN, Shen B. Structural Insights into the Free-standing Condensation Enzyme SgcC5 Catalyzing Ester Bond Formation in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027. Biochemistry. PMID 29533601 DOI: 10.1021/Acs.Biochem.8B00174  0.746
2017 Annaval T, Rudolf JD, Chang CY, Lohman JR, Kim Y, Bigelow L, Jedrzejczak R, Babnigg G, Joachimiak A, Phillips GN, Shen B. Crystal Structure of Thioesterase SgcE10 Supporting Common Polyene Intermediates in 9- and 10-Membered Enediyne Core Biosynthesis. Acs Omega. 2: 5159-5169. PMID 28884166 DOI: 10.1021/acsomega.7b00933  0.744
2017 Rudolf JD, Chang CY, Ma M, Shen B. Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function. Natural Product Reports. PMID 28758170 DOI: 10.1039/C7Np00034K  0.542
2017 Falzone M, Crespo E, Jones K, Khan G, Korn VL, Patel A, Patel M, Patel K, Perkins C, Siddiqui S, Stenger D, Yu E, Gelber M, Scheffler R, Nayda V, ... ... Rudolf JD, et al. Nutritional control of antibiotic production by Streptomyces platensis MA7327: importance of l-aspartic acid. The Journal of Antibiotics. PMID 28465627 DOI: 10.1038/Ja.2017.49  0.547
2017 Dong LB, Rudolf JD, Lin L, Ruiz C, Cameron MD, Shen B. In vivo instability of platensimycin and platencin: Synthesis and biological evaluation of urea- and carbamate-platensimycin. Bioorganic & Medicinal Chemistry. PMID 28237556 DOI: 10.1016/J.Bmc.2017.02.028  0.544
2016 Yan X, Ge H, Huang T, Hindra, Yang D, Teng Q, Crnovčić I, Li X, Rudolf JD, Lohman JR, Gansemans Y, Zhu X, Huang Y, Zhao LX, Jiang Y, et al. Strain Prioritization and Genome Mining for Enediyne Natural Products. Mbio. 7. PMID 27999165 DOI: 10.1128/Mbio.02104-16  0.741
2016 Rudolf JD, Dong LB, Manoogian K, Shen B. Biosynthetic Origin of the Ether Ring in Platensimycin. Journal of the American Chemical Society. PMID 27966343 DOI: 10.1021/Jacs.6B09818  0.597
2016 Rudolf JD, Dong LB, Shen B. Platensimycin and Platencin: Inspirations for Chemistry, Biology, Enzymology, and Medicine. Biochemical Pharmacology. PMID 27865713 DOI: 10.1016/J.Bcp.2016.11.013  0.578
2016 Dong LB, Rudolf JD, Shen B. A Mutasynthetic Library of Platensimycin and Platencin Analogues. Organic Letters. PMID 27599271 DOI: 10.1021/Acs.Orglett.6B02248  0.496
2016 Chang CY, Lohman JR, Cao H, Tan K, Rudolf JD, Ma M, Xu W, Bingman CA, Yennamalli RM, Bigelow L, Babnigg G, Yan X, Joachimiak A, Phillips GN, Shen B. Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase that Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate in Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus. Biochemistry. PMID 27560143 DOI: 10.1021/Acs.Biochem.6B00713  0.749
2016 Ma M, Rateb ME, Yang D, Rudolf JD, Zhu X, Huang Y, Zhao LX, Jiang Y, Duan Y, Shen B. Germicidins H-J from Streptomyces sp. CB00361. The Journal of Antibiotics. PMID 27507632 DOI: 10.1038/Ja.2016.100  0.421
2016 Rudolf JD, Dong LB, Cao H, Hatzos-Skintges C, Osipiuk J, Endres M, Chang CY, Ma M, Babnigg G, Joachimiak A, Phillips GN, Shen B. Structure of the ent-Copalyl Diphosphate Synthase PtmT2 from Streptomyces platensis CB00739, a Bacterial Type II Diterpene Synthase. Journal of the American Chemical Society. PMID 27490479 DOI: 10.1021/Jacs.6B04317  0.55
2016 Huang T, Chang CY, Lohman JR, Rudolf JD, Kim Y, Chang C, Yang D, Ma M, Yan X, Crnovcic I, Bigelow L, Clancy S, Bingman CA, Yennamalli RM, Babnigg G, et al. Crystal structure of SgcJ, an NTF2-like superfamily protein involved in biosynthesis of the nine-membered enediyne antitumor antibiotic C-1027. The Journal of Antibiotics. PMID 27406907 DOI: 10.1038/Ja.2016.88  0.75
2016 Dong LB, Rudolf JD, Shen B. Antibacterial sulfur-containing platensimycin and platencin congeners from Streptomyces platensis SB12029. Bioorganic & Medicinal Chemistry. PMID 27134119 DOI: 10.1016/J.Bmc.2016.04.026  0.578
2015 Rudolf JD, Bigelow L, Chang C, Cuff ME, Lohman JR, Chang CY, Ma M, Yang D, Clancy S, Babnigg G, Joachimiak A, Phillips GN, Shen B. Crystal Structure of the Zorbamycin-Binding Protein ZbmA, the Primary Self-Resistance Element in Streptomyces flavoviridis ATCC21892. Biochemistry. PMID 26512730 DOI: 10.1021/Acs.Biochem.5B01008  0.724
2015 Ma M, Rateb ME, Teng Q, Yang D, Rudolf JD, Zhu X, Huang Y, Zhao LX, Jiang Y, Li X, Rader C, Duan Y, Shen B. Angucyclines and Angucyclinones from Streptomyces sp. CB01913 Featuring C-Ring Cleavage and Expansion. Journal of Natural Products. PMID 26335269 DOI: 10.1021/Acs.Jnatprod.5B00601  0.561
2015 Rudolf JD, Yan X, Shen B. Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery. Journal of Industrial Microbiology & Biotechnology. PMID 26318027 DOI: 10.1007/S10295-015-1671-0  0.53
2015 Rudolf JD, Dong LB, Huang T, Shen B. A genetically amenable platensimycin- and platencin-overproducer as a platform for biosynthetic explorations: a showcase of PtmO4, a long-chain acyl-CoA dehydrogenase. Molecular Biosystems. PMID 26055255 DOI: 10.1039/C5Mb00303B  0.574
2015 Shen B, Hindra, Yan X, Huang T, Ge H, Yang D, Teng Q, Rudolf JD, Lohman JR. Enediynes: Exploration of microbial genomics to discover new anticancer drug leads. Bioorganic & Medicinal Chemistry Letters. 25: 9-15. PMID 25434000 DOI: 10.1016/J.Bmcl.2014.11.019  0.704
2014 Coughlin JM, Rudolf JD, Wendt-Pienkowski E, Wang L, Unsin C, Galm U, Yang D, Tao M, Shen B. BlmB and TlmB provide resistance to the bleomycin family of antitumor antibiotics by N-acetylating metal-free bleomycin, tallysomycin, phleomycin, and zorbamycin. Biochemistry. 53: 6901-9. PMID 25299801 DOI: 10.1021/Bi501121E  0.746
2014 Hindra, Huang T, Yang D, Rudolf JD, Xie P, Xie G, Teng Q, Lohman JR, Zhu X, Huang Y, Zhao LX, Jiang Y, Duan Y, Shen B. Strain prioritization for natural product discovery by a high-throughput real-time PCR method. Journal of Natural Products. 77: 2296-303. PMID 25238028 DOI: 10.1021/Np5006168  0.708
2014 Ge HM, Huang T, Rudolf JD, Lohman JR, Huang SX, Guo X, Shen B. Enediyne polyketide synthases stereoselectively reduce the β-ketoacyl intermediates to β-D-hydroxyacyl intermediates in enediyne core biosynthesis. Organic Letters. 16: 3958-61. PMID 25019332 DOI: 10.1021/Ol501767V  0.688
2014 Peterson RM, Huang T, Rudolf JD, Smanski MJ, Shen B. Mechanisms of self-resistance in the platensimycin- and platencin-producing Streptomyces platensis MA7327 and MA7339 strains. Chemistry & Biology. 21: 389-97. PMID 24560608 DOI: 10.1016/J.Chembiol.2014.01.005  0.727
2014 Xie P, Ma M, Rateb ME, Shaaban KA, Yu Z, Huang SX, Zhao LX, Zhu X, Yan Y, Peterson RM, Lohman JR, Yang D, Yin M, Rudolf JD, Jiang Y, et al. Biosynthetic potential-based strain prioritization for natural product discovery: a showcase for diterpenoid-producing actinomycetes. Journal of Natural Products. 77: 377-87. PMID 24484381 DOI: 10.1021/Np401063S  0.73
2013 Rudolf JD, Poulter CD. Tyrosine O-prenyltransferase SirD catalyzes S-, C-, and N-prenylations on tyrosine and tryptophan derivatives. Acs Chemical Biology. 8: 2707-14. PMID 24083562 DOI: 10.1021/Cb400691Z  0.549
2013 Rudolf JD, Wang H, Poulter CD. Correction to multisite prenylation of 4-substituted tryptophans by dimethylallyltryptophan synthase. Journal of the American Chemical Society. 135: 10879. PMID 23848360 DOI: 10.1021/Ja405989J  0.483
2013 Rudolf JD, Wang H, Poulter CD. Multisite prenylation of 4-substituted tryptophans by dimethylallyltryptophan synthase. Journal of the American Chemical Society. 135: 1895-902. PMID 23301871 DOI: 10.1021/Ja310734N  0.602
Low-probability matches (unlikely to be authored by this person)
2023 Li Z, Xu B, Kojasoy V, Ortega T, Adpressa DA, Ning W, Wei X, Liu J, Tantillo DJ, Loesgen S, Rudolf JD. First -eunicellane terpene synthase in bacteria. Chem. 9: 698-708. PMID 36937101 DOI: 10.1016/j.chempr.2022.12.006  0.298
2021 Xu B, Li Z, Alsup TA, Ehrenberger MA, Rudolf JD. Bacterial diterpene synthases prenylate small molecules. Acs Catalysis. 11: 5906-5915. PMID 34796043 DOI: 10.1021/ACSCATAL.1C01113  0.297
2023 Li Z, Rudolf JD. Biosynthesis, enzymology, and future of eunicellane diterpenoids. Journal of Industrial Microbiology & Biotechnology. PMID 37673680 DOI: 10.1093/jimb/kuad027  0.291
2022 Xu B, Ning W, Wei X, Rudolf JD. Mutation of the eunicellane synthase Bnd4 alters its product profile and expands its prenylation ability. Organic & Biomolecular Chemistry. 20: 8833-8837. PMID 36321628 DOI: 10.1039/d2ob01931k  0.261
2022 Stowell EA, Ehrenberger MA, Lin YL, Chang CY, Rudolf JD. Structure-guided product determination of the bacterial type II diterpene synthase Tpn2. Communications Chemistry. 5: 146. PMID 36698006 DOI: 10.1038/s42004-022-00765-6  0.251
2023 Li Z, Xu B, Alsup TA, Wei X, Ning W, Icenhour DG, Ehrenberger MA, Ghiviriga I, Giang BD, Rudolf JD. Cryptic Isomerization in Diterpene Biosynthesis and the Restoration of an Evolutionarily Defunct P450. Journal of the American Chemical Society. 145: 22361-22365. PMID 37813821 DOI: 10.1021/jacs.3c09446  0.248
2023 Pan X, Rudolf JD, Dong LB. Class II terpene cyclases: structures, mechanisms, and engineering. Natural Product Reports. PMID 38105714 DOI: 10.1039/d3np00033h  0.236
2021 van Santen JA, Poynton EF, Iskakova D, McMann E, Alsup TA, Clark TN, Fergusson CH, Fewer DP, Hughes AH, McCadden CA, Parra J, Soldatou S, Rudolf JD, Janssen EM, Duncan KR, et al. The Natural Products Atlas 2.0: a database of microbially-derived natural products. Nucleic Acids Research. PMID 34718710 DOI: 10.1093/nar/gkab941  0.226
2021 Xu B, Tantillo D, Rudolf J. Mechanistic Insights into the Formation of the 6,10-Bicyclic Eunicellane Skeleton by the Bacterial Diterpene Synthase Bnd4. Angewandte Chemie (International Ed. in English). PMID 34378291 DOI: 10.1002/anie.202109641  0.225
2022 Pan X, Du W, Zhang X, Lin X, Li FR, Yang Q, Wang H, Rudolf JD, Zhang B, Dong LB. Discovery, Structure, and Mechanism of a Class II Sesquiterpene Cyclase. Journal of the American Chemical Society. PMID 36416740 DOI: 10.1021/jacs.2c09412  0.214
2022 Chen IH, Cheng T, Wang YL, Huang SJ, Hsiao YH, Lai YT, Toh SI, Chu J, Rudolf JD, Chang CY. Characterization and structural determination of CmnG-A, the adenylation domain that activates the nonproteinogenic amino acid capreomycidine in capreomycin biosynthesis. Chembiochem : a European Journal of Chemical Biology. PMID 36278314 DOI: 10.1002/cbic.202200563  0.201
2022 de Crécy-Lagard V, Amorin de Hegedus R, Arighi C, Babor J, Bateman A, Blaby I, Blaby-Haas C, Bridge AJ, Burley SK, Cleveland S, Colwell LJ, Conesa A, Dallago C, Danchin A, de Waard A, ... ... Rudolf JD, et al. A roadmap for the functional annotation of protein families: a community perspective. Database : the Journal of Biological Databases and Curation. 2022. PMID 35961013 DOI: 10.1093/database/baac062  0.137
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