Year |
Citation |
Score |
2021 |
Galanopoulou AS, Löscher W, Lubbers L, O'Brien TJ, Staley K, Vezzani A, D'Ambrosio R, White HS, Sontheimer H, Wolf JA, Twyman R, Whittemore V, Wilcox KS, Klein B. Antiepileptogenesis and disease modification: Progress, challenges, and the path forward-Report of the Preclinical Working Group of the 2018 NINDS-sponsored antiepileptogenesis and disease modification workshop. Epilepsia Open. PMID 34033232 DOI: 10.1002/epi4.12490 |
0.418 |
|
2018 |
Metcalf CS, Klein BD, Smith MD, Ceusters M, Lavreysen H, Pype S, Van Osselaer N, Twyman R, White HS. Potent and selective pharmacodynamic synergy between the metabotropic glutamate receptor subtype 2-positive allosteric modulator JNJ-46356479 and levetiracetam in the mouse 6-Hz (44-mA) model. Epilepsia. PMID 29360159 DOI: 10.1111/Epi.14005 |
0.434 |
|
2017 |
Klein BD, Jacobson CA, Metcalf CS, Smith MD, Wilcox KS, Hampson AJ, Kehne JH. Evaluation of Cannabidiol in Animal Seizure Models by the Epilepsy Therapy Screening Program (ETSP). Neurochemical Research. PMID 28478594 DOI: 10.1007/S11064-017-2287-8 |
0.566 |
|
2017 |
Kehne JH, Klein BD, Raeissi S, Sharma S. The National Institute of Neurological Disorders and Stroke (NINDS) Epilepsy Therapy Screening Program (ETSP). Neurochemical Research. PMID 28462454 DOI: 10.1007/S11064-017-2275-Z |
0.435 |
|
2017 |
Metcalf CS, Smith MD, Klein BD, McDougle DR, Zhang L, Bulaj G. Preclinical Analgesic and Safety Evaluation of the GalR2-preferring Analog, NAX 810-2. Neurochemical Research. PMID 28382595 DOI: 10.1007/S11064-017-2229-5 |
0.304 |
|
2017 |
Metcalf CS, Klein BD, Smith MD, Pruess T, Ceusters M, Lavreysen H, Pype S, Van Osselaer N, Twyman R, White HS. Efficacy of mGlu2 -positive allosteric modulators alone and in combination with levetiracetam in the mouse 6 Hz model of psychomotor seizures. Epilepsia. PMID 28166368 DOI: 10.1111/Epi.13659 |
0.555 |
|
2017 |
Metcalf CS, Klein BD, McDougle DR, Zhang L, Kaufmann D, Bulaj G, White HS. Preclinical evaluation of intravenous NAX 810-2, a novel GalR2-preferring analog, for anticonvulsant efficacy and pharmacokinetics. Epilepsia. PMID 28098336 DOI: 10.1111/Epi.13647 |
0.598 |
|
2017 |
Metcalf C, Klein B, McDougle D, Zhang L, Bulaj G, Steve White H. NAX 810-2, A Novel Galanin-Based Therapy for Epilepsy Neuropeptides. 65: 150. DOI: 10.1016/J.Npep.2017.02.071 |
0.446 |
|
2015 |
Metcalf CS, Klein BD, McDougle DR, Zhang L, Smith MD, Bulaj G, White HS. Analgesic properties of a peripherally acting and GalR2 receptor-preferring galanin analog in inflammatory, neuropathic, and acute pain models. The Journal of Pharmacology and Experimental Therapeutics. 352: 185-93. PMID 25347995 DOI: 10.1124/Jpet.114.219063 |
0.466 |
|
2014 |
Jequier Gygax M, Klein BD, White HS, Kim M, Galanopoulou AS. Efficacy and tolerability of the galanin analog NAX 5055 in the multiple-hit rat model of symptomatic infantile spasms. Epilepsy Research. 108: 98-108. PMID 24252685 DOI: 10.1016/J.Eplepsyres.2013.10.015 |
0.463 |
|
2013 |
McComsey DF, Smith-Swintosky VL, Parker MH, Brenneman DE, Malatynska E, White HS, Klein BD, Wilcox KS, Milewski ME, Herb M, Finley MF, Liu Y, Lubin ML, Qin N, Reitz AB, et al. Novel, broad-spectrum anticonvulsants containing a sulfamide group: pharmacological properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112). Journal of Medicinal Chemistry. 56: 9019-30. PMID 24205976 DOI: 10.1021/Jm400894U |
0.583 |
|
2013 |
Zhang L, Klein BD, Metcalf CS, Smith MD, McDougle DR, Lee HK, White HS, Bulaj G. Incorporation of monodisperse oligoethyleneglycol amino acids into anticonvulsant analogues of galanin and neuropeptide y provides peripherally acting analgesics. Molecular Pharmaceutics. 10: 574-85. PMID 23259957 DOI: 10.1021/Mp300236V |
0.47 |
|
2013 |
Green BR, Klein BD, Lee HK, Smith MD, Steve White H, Bulaj G. Cyclic analogs of galanin and neuropeptide Y by hydrocarbon stapling. Bioorganic & Medicinal Chemistry. 21: 303-10. PMID 23176753 DOI: 10.1016/J.Bmc.2012.10.026 |
0.508 |
|
2010 |
Green BR, White KL, McDougle DR, Zhang L, Klein B, Scholl EA, Pruess TH, White HS, Bulaj G. Introduction of lipidization-cationization motifs affords systemically bioavailable neuropeptide Y and neurotensin analogs with anticonvulsant activities. Journal of Peptide Science : An Official Publication of the European Peptide Society. 16: 486-95. PMID 20645434 DOI: 10.1002/Psc.1266 |
0.475 |
|
2009 |
Parker MH, Smith-Swintosky VL, McComsey DF, Huang Y, Brenneman D, Klein B, Malatynska E, White HS, Milewski ME, Herb M, Finley MF, Liu Y, Lubin ML, Qin N, Iannucci R, et al. Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies. Journal of Medicinal Chemistry. 52: 7528-36. PMID 19388676 DOI: 10.1021/Jm801432R |
0.506 |
|
2009 |
White HS, Scholl EA, Klein BD, Flynn SP, Pruess TH, Green BR, Zhang L, Bulaj G. Developing novel antiepileptic drugs: characterization of NAX 5055, a systemically-active galanin analog, in epilepsy models. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 6: 372-80. PMID 19332332 DOI: 10.1016/J.Nurt.2009.01.001 |
0.693 |
|
2007 |
Novak GP, Kelley M, Zannikos P, Klein B. Carisbamate (RWJ-333369). Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 4: 106-9. PMID 17199023 DOI: 10.1016/j.nurt.2006.11.016 |
0.32 |
|
2005 |
Klein BD, Fu YH, Ptacek LJ, White HS. Auditory deficits associated with the frings mgr1 (mass1) mutation in mice. Developmental Neuroscience. 27: 321-32. PMID 16137990 DOI: 10.1159/000086712 |
0.401 |
|
2004 |
Klein BD, Fu YH, Ptacek LJ, White HS. c-Fos immunohistochemical mapping of the audiogenic seizure network and tonotopic neuronal hyperexcitability in the inferior colliculus of the Frings mouse. Epilepsy Research. 62: 13-25. PMID 15519128 DOI: 10.1016/J.Eplepsyres.2004.06.007 |
0.527 |
|
2003 |
Isoherranen N, White HS, Klein BD, Roeder M, Woodhead JH, Schurig V, Yagen B, Bialer M. Pharmacokinetic-pharmacodynamic relationships of (2S,3S)-valnoctamide and its stereoisomer (2R,3S)-valnoctamide in rodent models of epilepsy. Pharmaceutical Research. 20: 1293-301. PMID 12948028 DOI: 10.1023/A:1025069519218 |
0.487 |
|
2001 |
Barton ME, Klein BD, Wolf HH, White HS. Pharmacological characterization of the 6 Hz psychomotor seizure model of partial epilepsy. Epilepsy Research. 47: 217-27. PMID 11738929 DOI: 10.1016/S0920-1211(01)00302-3 |
0.651 |
|
2000 |
Klein BD, White HS, Callahan KS. Cytokine and intracellular signaling regulation of tissue factor expression in astrocytes. Neurochemistry International. 36: 441-9. PMID 10733012 DOI: 10.1016/S0197-0186(99)00147-3 |
0.379 |
|
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