| Year |
Citation |
Score |
| 2024 |
Tong Y, Zhang P, Yang X, Liu X, Zhang J, Grudniewska M, Jung I, Abegg D, Liu J, Childs-Disney JL, Gibaut QMR, Haniff HS, Adibekian A, Mouradian MM, Disney MD. Decreasing the intrinsically disordered protein α-synuclein levels by targeting its structured mRNA with a ribonuclease-targeting chimera. Proceedings of the National Academy of Sciences of the United States of America. 121: e2306682120. PMID 38181056 DOI: 10.1073/pnas.2306682120 |
0.689 |
|
| 2023 |
Komlosh PG, Chen JL, Childs-Disney J, Disney MD, Canaani D. Broad-spectrum metastasis suppressing compounds and therapeutic uses thereof in human tumors. Scientific Reports. 13: 20420. PMID 37990044 DOI: 10.1038/s41598-023-47478-x |
0.554 |
|
| 2023 |
Springer NA, Meyer SM, Taghavi A, Benhamou RI, Tong Y, Childs-Disney JL, Disney MD. Methods for the study of ribonuclease targeting chimeras (RiboTACs). Methods in Enzymology. 692: 249-298. PMID 37925183 DOI: 10.1016/bs.mie.2023.06.006 |
0.666 |
|
| 2023 |
Suresh BM, Tong Y, Abegg D, Adibekian A, Childs-Disney JL, Disney MD. Altering the Cleaving Effector in Chimeric Molecules that Target RNA Enhances Cellular Selectivity. Acs Chemical Biology. PMID 37824291 DOI: 10.1021/acschembio.3c00363 |
0.744 |
|
| 2023 |
Gibaut QMR, Bush JA, Tong Y, Baisden JT, Taghavi A, Olafson H, Yao X, Childs-Disney JL, Wang ET, Disney MD. Transcriptome-Wide Studies of RNA-Targeted Small Molecules Provide a Simple and Selective r(CUG) Degrader in Myotonic Dystrophy. Acs Central Science. 9: 1342-1353. PMID 37521782 DOI: 10.1021/acscentsci.2c01223 |
0.744 |
|
| 2023 |
Tong Y, Lee Y, Liu X, Childs-Disney JL, Suresh BM, Benhamou RI, Yang C, Li W, Costales MG, Haniff HS, Sievers S, Abegg D, Wegner T, Paulisch TO, Lekah E, et al. Programming inactive RNA-binding small molecules into bioactive degraders. Nature. PMID 37225982 DOI: 10.1038/s41586-023-06091-8 |
0.774 |
|
| 2023 |
Taghavi A, Baisden JT, Childs-Disney JL, Yildirim I, Disney MD. Conformational dynamics of RNA G4C2 and G2C4 repeat expansions causing ALS/FTD using NMR and molecular dynamics studies. Nucleic Acids Research. PMID 37216594 DOI: 10.1093/nar/gkad403 |
0.549 |
|
| 2023 |
Suresh BM, Taghavi A, Childs-Disney JL, Disney MD. Fragment-Based Approaches to Identify RNA Binders. Journal of Medicinal Chemistry. PMID 37186875 DOI: 10.1021/acs.jmedchem.3c00034 |
0.745 |
|
| 2023 |
Tong Y, Gibaut QMR, Rouse W, Childs-Disney JL, Suresh BM, Abegg D, Choudhary S, Akahori Y, Adibekian A, Moss WN, Disney MD. Correction to "Transcriptome-Wide Mapping of Small-Molecule RNA-Binding Sites in Cells Informs an Isoform-Specific Degrader of mRNA". Journal of the American Chemical Society. PMID 37058601 DOI: 10.1021/jacs.3c02644 |
0.783 |
|
| 2022 |
Bush JA, Meyer SM, Fuerst R, Tong Y, Li Y, Benhamou RI, Aikawa H, Zanon PRA, Gibaut QMR, Angelbello AJ, Gendron TF, Zhang YJ, Petrucelli L, Heick Jensen T, Childs-Disney JL, et al. A blood-brain penetrant RNA-targeted small molecule triggers elimination of r(GC) in c9ALS/FTD via the nuclear RNA exosome. Proceedings of the National Academy of Sciences of the United States of America. 119: e2210532119. PMID 36409902 DOI: 10.1073/pnas.2210532119 |
0.751 |
|
| 2022 |
Childs-Disney JL, Yang X, Gibaut QMR, Tong Y, Batey RT, Disney MD. Targeting RNA structures with small molecules. Nature Reviews. Drug Discovery. PMID 35941229 DOI: 10.1038/s41573-022-00521-4 |
0.753 |
|
| 2022 |
Tong Y, Gibaut QMR, Rouse W, Childs-Disney JL, Suresh BM, Abegg D, Choudhary S, Akahori Y, Adibekian A, Moss WN, Disney MD. . Journal of the American Chemical Society. 144: 11620-11625. PMID 35737519 DOI: 10.1021/jacs.2c01929 |
0.831 |
|
| 2022 |
Yang X, Childs-Disney JL, Disney MD. A meditation on accelerating the development of small molecule medicines targeting RNA. Expert Opinion On Drug Discovery. 1-3. PMID 35658797 DOI: 10.1080/17460441.2022.2084528 |
0.734 |
|
| 2022 |
Benhamou RI, Suresh BM, Tong Y, Cochrane WG, Cavett V, Vezina-Dawod S, Abegg D, Childs-Disney JL, Adibekian A, Paegel BM, Disney MD. DNA-encoded library versus RNA-encoded library selection enables design of an oncogenic noncoding RNA inhibitor. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35110406 DOI: 10.1073/pnas.2114971119 |
0.65 |
|
| 2021 |
Bush JA, Aikawa H, Fuerst R, Li Y, Ursu A, Meyer SM, Benhamou RI, Chen JL, Khan T, Wagner-Griffin S, Van Meter MJ, Tong Y, Olafson H, McKee KK, Childs-Disney JL, et al. Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(GC) repeat expansion in vitro and in vivo ALS models. Science Translational Medicine. 13: eabd5991. PMID 34705518 DOI: 10.1126/scitranslmed.abd5991 |
0.543 |
|
| 2021 |
Zhang P, Liu X, Abegg D, Tanaka T, Tong Y, Benhamou RI, Baisden J, Crynen G, Meyer SM, Cameron MD, Chatterjee AK, Adibekian A, Childs-Disney JL, Disney MD. Reprogramming of Protein-Targeted Small-Molecule Medicines to RNA by Ribonuclease Recruitment. Journal of the American Chemical Society. PMID 34387474 DOI: 10.1021/jacs.1c02248 |
0.728 |
|
| 2021 |
Bush JA, Williams CC, Meyer SM, Tong Y, Haniff HS, Childs-Disney JL, Disney MD. Systematically Studying the Effect of Small Molecules Interacting with RNA in Cellular and Preclinical Models. Acs Chemical Biology. PMID 34166593 DOI: 10.1021/acschembio.1c00014 |
0.743 |
|
| 2021 |
Baisden JT, Childs-Disney JL, Ryan LS, Disney MD. Affecting RNA biology genome-wide by binding small molecules and chemically induced proximity. Current Opinion in Chemical Biology. 62: 119-129. PMID 34118759 DOI: 10.1016/j.cbpa.2021.03.006 |
0.74 |
|
| 2021 |
Wagner-Griffin S, Abe M, Benhamou RI, Angelbello AJ, Vishnu K, Chen JL, Childs-Disney JL, Disney MD. A Druglike Small Molecule that Targets r(CCUG) Repeats in Myotonic Dystrophy Type 2 Facilitates Degradation by RNA Quality Control Pathways. Journal of Medicinal Chemistry. PMID 34101465 DOI: 10.1021/acs.jmedchem.1c00414 |
0.739 |
|
| 2020 |
Meyer SM, Williams CC, Akahori Y, Tanaka T, Aikawa H, Tong Y, Childs-Disney JL, Disney MD. Small molecule recognition of disease-relevant RNA structures. Chemical Society Reviews. PMID 32975549 DOI: 10.1039/d0cs00560f |
0.771 |
|
| 2020 |
Ursu A, Childs-Disney JL, Andrews RJ, O'Leary CA, Meyer SM, Angelbello AJ, Moss WN, Disney MD. Design of small molecules targeting RNA structure from sequence. Chemical Society Reviews. PMID 32935689 DOI: 10.1039/D0Cs00455C |
0.833 |
|
| 2020 |
Ursu A, Childs-Disney JL, Angelbello AJ, Costales MG, Meyer SM, Disney MD. Gini coefficients as a single value metric to define chemical probe selectivity. Acs Chemical Biology. PMID 32568503 DOI: 10.1021/Acschembio.0C00486 |
0.692 |
|
| 2020 |
Chen JL, Zhang P, Abe M, Aikawa H, Zhang L, Frank AJ, Zembryski T, Hubbs C, Park H, Withka J, Steppan C, Rogers L, Cabral S, Pettersson M, Wager TT, ... ... Childs-Disney JL, et al. Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing. Journal of the American Chemical Society. PMID 32364710 DOI: 10.1021/Jacs.0C00768 |
0.659 |
|
| 2020 |
Liu X, Haniff HS, Childs-Disney JL, Shuster A, Aikawa H, Adibekian A, Disney MD. Targeted Degradation of the Oncogenic MicroRNA 17-92 Cluster by Structure-Targeting Ligands. Journal of the American Chemical Society. PMID 32233464 DOI: 10.1021/Jacs.9B13159 |
0.609 |
|
| 2020 |
Costales MG, Childs-Disney JL, Haniff HS, Disney MD. How We Think about Targeting RNA with Small Molecules. Journal of Medicinal Chemistry. PMID 32212706 DOI: 10.1021/Acs.Jmedchem.9B01927 |
0.76 |
|
| 2020 |
Disney MD, Suresh BM, Benhamou RI, Childs-Disney JL. Progress toward the development of the small molecule equivalent of small interfering RNA. Current Opinion in Chemical Biology. 56: 63-71. PMID 32036231 DOI: 10.1016/J.Cbpa.2020.01.001 |
0.769 |
|
| 2020 |
Costales MG, Aikawa H, Li Y, Childs-Disney JL, Abegg D, Hoch DG, Pradeep Velagapudi S, Nakai Y, Khan T, Wang KW, Yildirim I, Adibekian A, Wang ET, Disney MD. Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 31964809 DOI: 10.1073/Pnas.1914286117 |
0.757 |
|
| 2020 |
Zhang P, Park HJ, Zhang J, Junn E, Andrews RJ, Velagapudi SP, Abegg D, Vishnu K, Costales MG, Childs-Disney JL, Adibekian A, Moss WN, Mouradian MM, Disney MD. Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA. Proceedings of the National Academy of Sciences of the United States of America. PMID 31900363 DOI: 10.1073/Pnas.1905057117 |
0.741 |
|
| 2019 |
Chen JL, Moss WN, Spencer A, Zhang P, Childs-Disney JL, Disney MD. The RNA encoding the microtubule-associated protein tau has extensive structure that affects its biology. Plos One. 14: e0219210. PMID 31291322 DOI: 10.1371/Journal.Pone.0219210 |
0.759 |
|
| 2019 |
Disney MD, Velagapudi SP, Li Y, Costales MG, Childs-Disney JL. Identifying and validating small molecules interacting with RNA (SMIRNAs). Methods in Enzymology. 623: 45-66. PMID 31239057 DOI: 10.1016/Bs.Mie.2019.04.027 |
0.771 |
|
| 2019 |
O'Leary CA, Andrews RJ, Tompkins VS, Chen JL, Childs-Disney JL, Disney MD, Moss WN. RNA structural analysis of the MYC mRNA reveals conserved motifs that affect gene expression. Plos One. 14: e0213758. PMID 31206539 DOI: 10.1371/Journal.Pone.0213758 |
0.751 |
|
| 2019 |
Costales MG, Hoch DG, Abegg D, Childs-Disney JL, Velagapudi SP, Adibekian A, Disney MD. A Designed Small Molecule Inhibitor of a Non-Coding RNA Sensitizes HER2 Negative Cancers to Herceptin. Journal of the American Chemical Society. PMID 30726072 DOI: 10.1021/Jacs.8B10558 |
0.586 |
|
| 2018 |
Childs-Disney JL, Tran T, Vummidi BR, Velagapudi SP, Haniff HS, Matsumoto Y, Crynen G, Southern MR, Biswas A, Wang ZF, Tellinghuisen TL, Disney MD. A Massively Parallel Selection of Small Molecule-RNA Motif Binding Partners Informs Design of an Antiviral from Sequence. Chem. 4: 2384-2404. PMID 30719503 DOI: 10.1016/J.Chempr.2018.08.003 |
0.746 |
|
| 2018 |
Wang ZF, Ursu A, Childs-Disney JL, Guertler R, Yang WY, Bernat V, Rzuczek SG, Fuerst R, Zhang YJ, Gendron TF, Yildirim I, Dwyer BG, Rice JE, Petrucelli L, Disney MD. The Hairpin Form of r(GC) in c9ALS/FTD Is Repeat-Associated Non-ATG Translated and a Target for Bioactive Small Molecules. Cell Chemical Biology. PMID 30503283 DOI: 10.1016/J.Chembiol.2018.10.018 |
0.666 |
|
| 2018 |
Disney MD, Dwyer BG, Childs-Disney JL. Drugging the RNA World. Cold Spring Harbor Perspectives in Biology. 10. PMID 30385607 DOI: 10.1101/Cshperspect.A034769 |
0.762 |
|
| 2018 |
Velagapudi SP, Costales MG, Vummidi BR, Nakai Y, Angelbello AJ, Tran T, Haniff HS, Matsumoto Y, Wang ZF, Chatterjee AK, Childs-Disney JL, Disney MD. Approved Anti-cancer Drugs Target Oncogenic Non-coding RNAs. Cell Chemical Biology. 25: 1086-1094.e7. PMID 30251629 DOI: 10.1016/J.Chembiol.2018.05.015 |
0.718 |
|
| 2018 |
Angelbello AJ, Chen JL, Childs-Disney JL, Zhang P, Wang ZF, Disney MD. Using Genome Sequence to Enable the Design of Medicines and Chemical Probes. Chemical Reviews. PMID 29322778 DOI: 10.1021/Acs.Chemrev.7B00504 |
0.596 |
|
| 2017 |
Velagapudi SP, Luo Y, Tran T, Haniff HS, Nakai Y, Fallahi M, Martinez GJ, Childs-Disney JL, Disney MD. Defining RNA-Small Molecule Affinity Landscapes Enables Design of a Small Molecule Inhibitor of an Oncogenic Noncoding RNA. Acs Central Science. 3: 205-216. PMID 28386598 DOI: 10.1021/Acscentsci.7B00009 |
0.731 |
|
| 2017 |
Costales MG, Haga CL, Velagapudi SP, Childs-Disney JL, Phinney DG, Disney MD. Small Molecule Inhibition of microRNA-210 Reprograms an Oncogenic Hypoxic Circuit. Journal of the American Chemical Society. PMID 28240549 DOI: 10.1021/Jacs.6B11273 |
0.69 |
|
| 2017 |
Haga CL, Velagapudi SP, Childs-Disney JL, Strivelli J, Disney MD, Phinney DG. Rapid Generation of miRNA Inhibitor Leads by Bioinformatics and Efficient High-Throughput Screening Methods. Methods in Molecular Biology (Clifton, N.J.). 1517: 179-198. PMID 27924483 DOI: 10.1007/978-1-4939-6563-2_13 |
0.567 |
|
| 2016 |
Disney MD, Winkelsas AM, Velagapudi SP, Southern M, Fallahi M, Childs-Disney JL. Inforna 2.0: A Platform for the Sequence-Based Design of Small Molecules Targeting Structured RNAs. Acs Chemical Biology. PMID 27097021 DOI: 10.1021/Acschembio.6B00001 |
0.772 |
|
| 2016 |
Liu B, Childs-Disney JL, Znosko BM, Wang D, Fallahi M, Gallo SM, Disney MD. Analysis of secondary structural elements in human microRNA hairpin precursors. Bmc Bioinformatics. 17: 112. PMID 26928172 DOI: 10.1186/S12859-016-0960-6 |
0.543 |
|
| 2015 |
Childs-Disney JL, Disney MD. Small Molecule Targeting of a MicroRNA Associated with Hepatocellular Carcinoma in Cellulo. Acs Chemical Biology. PMID 26551630 DOI: 10.1021/Acschembio.5B00615 |
0.584 |
|
| 2015 |
Childs-Disney JL, Disney MD. Approaches to Validate and Manipulate RNA Targets with Small Molecules in Cells. Annual Review of Pharmacology and Toxicology. PMID 26514201 DOI: 10.1146/Annurev-Pharmtox-010715-103910 |
0.741 |
|
| 2014 |
Tran T, Childs-Disney JL, Liu B, Guan L, Rzuczek S, Disney MD. Targeting the r(CGG) repeats that cause FXTAS with modularly assembled small molecules and oligonucleotides. Acs Chemical Biology. 9: 904-12. PMID 24506227 DOI: 10.1021/Cb400875U |
0.687 |
|
| 2014 |
Disney MD, Yildirim I, Childs-Disney JL. Methods to enable the design of bioactive small molecules targeting RNA. Organic & Biomolecular Chemistry. 12: 1029-39. PMID 24357181 DOI: 10.1039/C3Ob42023J |
0.758 |
|
| 2014 |
Childs-Disney JL, Yildirim I, Park H, Lohman JR, Guan L, Tran T, Sarkar P, Schatz GC, Disney MD. Structure of the myotonic dystrophy type 2 RNA and designed small molecules that reduce toxicity. Acs Chemical Biology. 9: 538-50. PMID 24341895 DOI: 10.1021/Cb4007387 |
0.638 |
|
| 2013 |
Childs-Disney JL, Stepniak-Konieczna E, Tran T, Yildirim I, Park H, Chen CZ, Hoskins J, Southall N, Marugan JJ, Patnaik S, Zheng W, Austin CP, Schatz GC, Sobczak K, Thornton CA, et al. Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules. Nature Communications. 4: 2044. PMID 23806903 DOI: 10.1038/Ncomms3044 |
0.659 |
|
| 2012 |
Childs-Disney JL, Parkesh R, Nakamori M, Thornton CA, Disney MD. Rational design of bioactive, modularly assembled aminoglycosides targeting the RNA that causes myotonic dystrophy type 1. Acs Chemical Biology. 7: 1984-93. PMID 23130637 DOI: 10.1021/Cb3001606 |
0.689 |
|
| 2012 |
Disney MD, Liu B, Yang WY, Sellier C, Tran T, Charlet-Berguerand N, Childs-Disney JL. A small molecule that targets r(CGG)(exp) and improves defects in fragile X-associated tremor ataxia syndrome. Acs Chemical Biology. 7: 1711-8. PMID 22948243 DOI: 10.1021/Cb300135H |
0.684 |
|
| 2012 |
Childs-Disney JL, Hoskins J, Rzuczek SG, Thornton CA, Disney MD. Rationally designed small molecules targeting the RNA that causes myotonic dystrophy type 1 are potently bioactive. Acs Chemical Biology. 7: 856-62. PMID 22332923 DOI: 10.1021/Cb200408A |
0.736 |
|
| 2012 |
Parkesh R, Childs-Disney JL, Nakamori M, Kumar A, Wang E, Wang T, Hoskins J, Tran T, Housman D, Thornton CA, Disney MD. Design of a bioactive small molecule that targets the myotonic dystrophy type 1 RNA via an RNA motif-ligand database and chemical similarity searching. Journal of the American Chemical Society. 134: 4731-42. PMID 22300544 DOI: 10.1021/Ja210088V |
0.753 |
|
| 2012 |
Kumar A, Parkesh R, Sznajder LJ, Childs-Disney JL, Sobczak K, Disney MD. Chemical correction of pre-mRNA splicing defects associated with sequestration of muscleblind-like 1 protein by expanded r(CAG)-containing transcripts. Acs Chemical Biology. 7: 496-505. PMID 22252896 DOI: 10.1021/cb200413a |
0.726 |
|
| 2011 |
Childs-Disney JL, Tsitovich PB, Disney MD. Using modularly assembled ligands to bind RNA internal loops separated by different distances. Chembiochem : a European Journal of Chemical Biology. 12: 2143-6. PMID 21830289 DOI: 10.1002/Cbic.201100298 |
0.728 |
|
| 2010 |
Disney MD, Lee MM, Pushechnikov A, Childs-Disney JL. The role of flexibility in the rational design of modularly assembled ligands targeting the RNAs that cause the myotonic dystrophies. Chembiochem : a European Journal of Chemical Biology. 11: 375-82. PMID 20058255 DOI: 10.1002/Cbic.200900716 |
0.725 |
|
| 2009 |
Lee MM, Childs-Disney JL, Pushechnikov A, French JM, Sobczak K, Thornton CA, Disney MD. Controlling the specificity of modularly assembled small molecules for RNA via ligand module spacing: targeting the RNAs that cause myotonic muscular dystrophy. Journal of the American Chemical Society. 131: 17464-72. PMID 19904940 DOI: 10.1021/Ja906877Y |
0.725 |
|
| 2009 |
Kauffmann AD, Campagna RJ, Bartels CB, Childs-Disney JL. Improvement of RNA secondary structure prediction using RNase H cleavage and randomized oligonucleotides. Nucleic Acids Research. 37: e121. PMID 19596816 DOI: 10.1093/nar/gkp587 |
0.343 |
|
| 2009 |
Pushechnikov A, Lee MM, Childs-Disney JL, Sobczak K, French JM, Thornton CA, Disney MD. Rational design of ligands targeting triplet repeating transcripts that cause RNA dominant disease: application to myotonic muscular dystrophy type 1 and spinocerebellar ataxia type 3. Journal of the American Chemical Society. 131: 9767-79. PMID 19552411 DOI: 10.1021/Ja9020149 |
0.716 |
|
| 2008 |
Aminova O, Paul DJ, Childs-Disney JL, Disney MD. Two-dimensional combinatorial screening identifies specific 6'-acylated kanamycin A- and 6'-acylated neamine-RNA hairpin interactions. Biochemistry. 47: 12670-9. PMID 18991404 DOI: 10.1021/Bi8012615 |
0.664 |
|
| 2008 |
Disney MD, Labuda LP, Paul DJ, Poplawski SG, Pushechnikov A, Tran T, Velagapudi SP, Wu M, Childs-Disney JL. Two-dimensional combinatorial screening identifies specific aminoglycoside-RNA internal loop partners. Journal of the American Chemical Society. 130: 11185-94. PMID 18652457 DOI: 10.1021/Ja803234T |
0.717 |
|
| 2008 |
Childs-Disney JL, Disney MD. A simple ligation-based method to increase the information density in sequencing reactions used to deconvolute nucleic acid selections. Rna (New York, N.Y.). 14: 390-4. PMID 18065718 DOI: 10.1261/Rna.576908 |
0.482 |
|
| 2007 |
Childs-Disney JL, Wu M, Pushechnikov A, Aminova O, Disney MD. A small molecule microarray platform to select RNA internal loop-ligand interactions. Acs Chemical Biology. 2: 745-54. PMID 17975888 DOI: 10.1021/Cb700174R |
0.729 |
|
| 2007 |
Disney MD, Childs-Disney JL. "Supra"molecular recognition of Galectin 1. Chemistry & Biology. 14: 1095-7. PMID 17961821 DOI: 10.1016/J.Chembiol.2007.10.002 |
0.491 |
|
| 2007 |
Disney MD, Childs-Disney JL. Using selection to identify and chemical microarray to study the RNA internal loops recognized by 6'-N-acylated kanamycin A. Chembiochem : a European Journal of Chemical Biology. 8: 649-56. PMID 17394189 DOI: 10.1002/Cbic.200600569 |
0.739 |
|
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